******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/worm/fasta/RankLinear2.0_40/bed-3.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chrM:148-228 1.0000 80 chrM:5503-5583 1.0000 80 chrV:265404-265484 1.0000 80 chrM:5726-5806 1.0000 80 chrII:2570633-2570713 1.0000 80 chrM:10796-10876 1.0000 80 chrI:933477-933557 1.0000 80 chrX:5056377-5056457 1.0000 80 chrM:3590-3670 1.0000 80 chrM:9391-9471 1.0000 80 chrM:2972-3052 1.0000 80 chrM:9982-10062 1.0000 80 chrIII:3500001-3500081 1.0000 80 chrV:4647941-4648021 1.0000 80 chrX:16944402-16944482 1.0000 80 chrV:16699860-16699940 1.0000 80 chrX:8156111-8156191 1.0000 80 chrM:7047-7127 1.0000 80 chrX:12693330-12693410 1.0000 80 chrX:13145005-13145085 1.0000 80 chrM:1309-1389 1.0000 80 chrIV:1377769-1377849 1.0000 80 chrM:7252-7332 1.0000 80 chrIII:931565-931645 1.0000 80 chrX:16602634-16602714 1.0000 80 chrX:8944253-8944333 1.0000 80 chrM:8336-8416 1.0000 80 chrI:3248554-3248634 1.0000 80 chrV:19723035-19723115 1.0000 80 chrX:14229608-14229688 1.0000 80 chrV:14689503-14689583 1.0000 80 chrM:7604-7684 1.0000 80 chrII:5399363-5399443 1.0000 80 chrX:11798195-11798275 1.0000 80 chrIII:6805574-6805654 1.0000 80 chrII:11974751-11974831 1.0000 80 chrV:15554019-15554099 1.0000 80 chrIII:3476305-3476385 1.0000 80 chrI:1575654-1575734 1.0000 80 chrIV:11605032-11605112 1.0000 80 chrM:2147-2227 1.0000 80 chrII:4130414-4130494 1.0000 80 chrV:12510026-12510106 1.0000 80 chrIII:8650404-8650484 1.0000 80 chrX:7651479-7651559 1.0000 80 chrII:15218082-15218162 1.0000 80 chrV:15505185-15505265 1.0000 80 chrV:3587753-3587833 1.0000 80 chrIV:842810-842890 1.0000 80 chrM:4617-4697 1.0000 80 chrIII:5769852-5769932 1.0000 80 chrV:13176485-13176565 1.0000 80 chrX:8925593-8925673 1.0000 80 chrII:5293363-5293443 1.0000 80 chrV:2674005-2674085 1.0000 80 chrII:8325298-8325378 1.0000 80 chrIV:605541-605621 1.0000 80 chrIV:5334738-5334818 1.0000 80 chrIII:1824689-1824769 1.0000 80 chrM:11041-11121 1.0000 80 chrII:6721730-6721810 1.0000 80 chrV:16553069-16553149 1.0000 80 chrV:7231015-7231095 1.0000 80 chrM:9180-9260 1.0000 80 chrII:3567694-3567774 1.0000 80 chrX:15347868-15347948 1.0000 80 chrIII:3664388-3664468 1.0000 80 chrIII:13713155-13713235 1.0000 80 chrII:7001604-7001684 1.0000 80 chrIV:1981123-1981203 1.0000 80 chrX:3914434-3914514 1.0000 80 chrI:1740964-1741044 1.0000 80 chrII:4238083-4238163 1.0000 80 chrX:3348076-3348156 1.0000 80 chrV:14855775-14855855 1.0000 80 chrIII:1122425-1122505 1.0000 80 chrIII:4426731-4426811 1.0000 80 chrX:8969660-8969740 1.0000 80 chrIII:10856982-10857062 1.0000 80 chrIV:11594148-11594228 1.0000 80 chrX:12367644-12367724 1.0000 80 chrII:11959350-11959430 1.0000 80 chrX:9102361-9102441 1.0000 80 chrIII:13780924-13781004 1.0000 80 chrV:1821467-1821547 1.0000 80 chrIII:13072032-13072112 1.0000 80 chrIV:15289689-15289769 1.0000 80 chrV:20832803-20832883 1.0000 80 chrX:5140202-5140282 1.0000 80 chrX:12693530-12693610 1.0000 80 chrIV:2639812-2639892 1.0000 80 chrIII:3175146-3175226 1.0000 80 chrIV:9316170-9316250 1.0000 80 chrM:1100-1180 1.0000 80 chrIII:1940069-1940149 1.0000 80 chrII:11157798-11157878 1.0000 80 chrM:12415-12495 1.0000 80 chrX:6286321-6286401 1.0000 80 chrI:6135783-6135863 1.0000 80 chrX:13781639-13781719 1.0000 80 chrIV:14576644-14576724 1.0000 80 chrI:6051192-6051272 1.0000 80 chrIV:9906185-9906265 1.0000 80 chrIV:11688012-11688092 1.0000 80 chrI:12225451-12225531 1.0000 80 chrI:9268892-9268972 1.0000 80 chrX:5336739-5336819 1.0000 80 chrX:9373131-9373211 1.0000 80 chrIV:2801148-2801228 1.0000 80 chrV:9293521-9293601 1.0000 80 chrI:8530145-8530225 1.0000 80 chrIII:1218371-1218451 1.0000 80 chrX:12890264-12890344 1.0000 80 chrX:13415146-13415226 1.0000 80 chrI:5312803-5312883 1.0000 80 chrI:853259-853339 1.0000 80 chrX:16551510-16551590 1.0000 80 chrX:8638926-8639006 1.0000 80 chrII:7679525-7679605 1.0000 80 chrIV:16863646-16863726 1.0000 80 chrX:9296723-9296803 1.0000 80 chrIII:8250400-8250480 1.0000 80 chrIII:12399871-12399951 1.0000 80 chrIII:12368828-12368908 1.0000 80 chrIII:640555-640635 1.0000 80 chrV:14876399-14876479 1.0000 80 chrII:6898170-6898250 1.0000 80 chrX:14115660-14115740 1.0000 80 chrV:1875697-1875777 1.0000 80 chrI:3567635-3567715 1.0000 80 chrV:5275164-5275244 1.0000 80 chrII:7708740-7708820 1.0000 80 chrIV:14013824-14013904 1.0000 80 chrX:8646452-8646532 1.0000 80 chrI:13421225-13421305 1.0000 80 chrX:6220062-6220142 1.0000 80 chrV:4143338-4143418 1.0000 80 chrX:5407403-5407483 1.0000 80 chrIII:7030598-7030678 1.0000 80 chrX:13653726-13653806 1.0000 80 chrIII:12598854-12598934 1.0000 80 chrIII:10094794-10094874 1.0000 80 chrIII:13225215-13225295 1.0000 80 chrIII:11091891-11091971 1.0000 80 chrIII:10432277-10432357 1.0000 80 chrV:5284760-5284840 1.0000 80 chrI:10807272-10807352 1.0000 80 chrX:14804848-14804928 1.0000 80 chrV:12331954-12332034 1.0000 80 chrX:8156312-8156392 1.0000 80 chrX:5319346-5319426 1.0000 80 chrX:16604662-16604742 1.0000 80 chrII:6827505-6827585 1.0000 80 chrIII:8106637-8106717 1.0000 80 chrI:1271215-1271295 1.0000 80 chrIII:4426933-4427013 1.0000 80 chrI:6532062-6532142 1.0000 80 chrX:8386227-8386307 1.0000 80 chrV:53456-53536 1.0000 80 chrIII:11236953-11237033 1.0000 80 chrV:4615965-4616045 1.0000 80 chrIV:1388206-1388286 1.0000 80 chrI:1823193-1823273 1.0000 80 chrI:1444096-1444176 1.0000 80 chrV:13962165-13962245 1.0000 80 chrX:16928294-16928374 1.0000 80 chrI:1415942-1416022 1.0000 80 chrX:8971575-8971655 1.0000 80 chrX:4444229-4444309 1.0000 80 chrII:5836599-5836679 1.0000 80 chrI:1175832-1175912 1.0000 80 chrX:16271300-16271380 1.0000 80 chrIV:3232990-3233070 1.0000 80 chrIII:6133576-6133656 1.0000 80 chrI:9605739-9605819 1.0000 80 chrI:4633642-4633722 1.0000 80 chrV:4731567-4731647 1.0000 80 chrV:20694112-20694192 1.0000 80 chrV:9583088-9583168 1.0000 80 chrV:12780414-12780494 1.0000 80 chrIV:620473-620553 1.0000 80 chrII:10169609-10169689 1.0000 80 chrII:14143938-14144018 1.0000 80 chrI:13434729-13434809 1.0000 80 chrIII:535397-535477 1.0000 80 chrX:12843689-12843769 1.0000 80 chrII:3521452-3521532 1.0000 80 chrV:11933422-11933502 1.0000 80 chrI:11978717-11978797 1.0000 80 chrIII:8971697-8971777 1.0000 80 chrIV:9191327-9191407 1.0000 80 chrII:10303919-10303999 1.0000 80 chrI:3873945-3874025 1.0000 80 chrIII:3476504-3476584 1.0000 80 chrI:14721619-14721699 1.0000 80 chrII:5772915-5772995 1.0000 80 chrII:4942495-4942575 1.0000 80 chrV:5592425-5592505 1.0000 80 chrX:9078313-9078393 1.0000 80 chrX:1837850-1837930 1.0000 80 chrX:11935087-11935167 1.0000 80 chrII:9566213-9566293 1.0000 80 chrIII:8768061-8768141 1.0000 80 chrV:11239339-11239419 1.0000 80 chrII:14635353-14635433 1.0000 80 chrX:1858810-1858890 1.0000 80 chrII:14063177-14063257 1.0000 80 chrII:8547118-8547198 1.0000 80 chrIV:796681-796761 1.0000 80 chrII:6248649-6248729 1.0000 80 chrX:5707971-5708051 1.0000 80 chrIII:8653084-8653164 1.0000 80 chrI:13310388-13310468 1.0000 80 chrX:6903116-6903196 1.0000 80 chrIII:4414247-4414327 1.0000 80 chrIV:11026146-11026226 1.0000 80 chrI:14756774-14756854 1.0000 80 chrI:1070004-1070084 1.0000 80 chrX:11467486-11467566 1.0000 80 chrV:15551794-15551874 1.0000 80 chrII:3439401-3439481 1.0000 80 chrIV:9477721-9477801 1.0000 80 chrII:12042369-12042449 1.0000 80 chrV:11113308-11113388 1.0000 80 chrX:15173641-15173721 1.0000 80 chrX:10821341-10821421 1.0000 80 chrX:13511961-13512041 1.0000 80 chrI:7095010-7095090 1.0000 80 chrIII:4171147-4171227 1.0000 80 chrIII:5305857-5305937 1.0000 80 chrI:7472518-7472598 1.0000 80 chrI:2410105-2410185 1.0000 80 chrIII:4568694-4568774 1.0000 80 chrX:10963770-10963850 1.0000 80 chrII:12678324-12678404 1.0000 80 chrIII:1604732-1604812 1.0000 80 chrV:6888990-6889070 1.0000 80 chrI:13161030-13161110 1.0000 80 chrV:12596963-12597043 1.0000 80 chrIII:3916787-3916867 1.0000 80 chrX:9091546-9091626 1.0000 80 chrV:10040010-10040090 1.0000 80 chrX:6371317-6371397 1.0000 80 chrX:9622793-9622873 1.0000 80 chrI:1958529-1958609 1.0000 80 chrX:9637864-9637944 1.0000 80 chrX:16298322-16298402 1.0000 80 chrII:7756968-7757048 1.0000 80 chrIII:10624727-10624807 1.0000 80 chrIII:1601590-1601670 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/worm/inference_raw/MEME/RankLinear2.0_40_bed-3/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/worm/fasta/RankLinear2.0_40/bed-3.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.247 C 0.234 G 0.247 T 0.272 Background letter frequencies (from file dataset with add-one prior applied): A 0.247 C 0.234 G 0.247 T 0.272 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TCGAACCC MEME-1 width = 8 sites = 46 llr = 390 E-value = 1.4e-015 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCGAACCC MEME-1 Description -------------------------------------------------------------------------------- Simplified A :::a6::2 pos.-specific C :8:::8a7 probability G ::a:1::: matrix T a2::32:1 bits 2.1 ** 1.9 * ** * 1.7 * ** * 1.5 * ** ** Relative 1.3 **** ** Entropy 1.0 **** ** (12.2 bits) 0.8 **** *** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TCGAACCC consensus T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCGAACCC MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:10821341-10821421 1 1.23e-05 . TCGAACCC GGGCCGCGTG chrII:3439401-3439481 8 1.23e-05 GCGGGGC TCGAACCC GCGACAACCA chrX:6903116-6903196 13 1.23e-05 AGAGTGGGAT TCGAACCC ACGCCCCCGA chrII:5772915-5772995 16 1.23e-05 CGAGTGGGGT TCGAACCC ACGAGGTGTT chrIV:620473-620553 63 1.23e-05 GGTCGCCGGT TCGAACCC GGCGAGGACC chrX:16271300-16271380 11 1.23e-05 TTGCGGGGAA TCGAACCC CGGCCTTATG chrIV:1388206-1388286 25 1.23e-05 ATGCCGGGAA TCGAACCC GGGCCGCGTG chrII:11157798-11157878 19 1.23e-05 AATGCGGGGC TCGAACCC GCGACAACCA chrX:12367644-12367724 13 1.23e-05 ATGCCGGGAA TCGAACCC GGGCCGCGTG chrV:15505185-15505265 38 1.23e-05 cgaccgggaa tcgaaccc gggccgcccg chrX:16298322-16298402 73 2.58e-05 GGTCGGCGGT TCGATCCC chrI:2410105-2410185 73 2.58e-05 GCGCGCTGGT TCGATCCC chrI:9268892-9268972 51 2.58e-05 GAGCCGGGGA TCGATCCC GGGACCTCTC chrIII:10624727-10624807 30 5.31e-05 CATGCTGGAA TCGAACCA GCGACCTTCT chrX:9637864-9637944 3 5.31e-05 AA TTGAACCC CAGCCCTCTC chrX:9622793-9622873 46 5.31e-05 GTATGGGGAA TTGAACCC CAGCCCTCTC chrX:13511961-13512041 24 5.31e-05 GAACCGGGGA TTGAACCC GGGACCTCTC chrV:15551794-15551874 20 5.31e-05 cggccgggaa ttgaaccc gggtctcgca chrII:3521452-3521532 50 5.31e-05 GCGGCTGGAA TCGAACCA GCGTCGCCAC chrX:16604662-16604742 73 5.31e-05 CGGCCGGGAA TTGAACCC chrV:12331954-12332034 26 5.31e-05 CCGGGTGGGC TCGAACCA CCAACCTTTC chrX:12890264-12890344 36 5.31e-05 GCACGGGGAA TTGAACCC CGGACTTCTC chrIV:2801148-2801228 18 5.31e-05 cggccgggaa ttgaaccc gggtctcgca chrX:16602634-16602714 15 5.31e-05 GGTGTGGGGG TCGAACCA TTAACCCCCC chrX:12843689-12843769 53 6.54e-05 GGTCGGTGGT TCGAGCCC GCCCGAGATC chrX:8386227-8386307 31 6.54e-05 GATTGCAGGT TCGAGCCC TGCCTGGGTC chrX:13781639-13781719 55 6.54e-05 TGTCGCGGGT TCGAGCCC CGCATTGGGC chrIII:6805574-6805654 48 6.54e-05 GGTTGGTGGT TCGAGCCC ACCCGGGAGC chrV:19723035-19723115 50 6.54e-05 GGTTGGTGGT TCGAGCCC ACCCGGGAGC chrIII:535397-535477 50 7.97e-05 GGTCACTGGT TCGAATCC GGTTCGACGG chrIV:11026146-11026226 12 9.39e-05 ACCGGTGGTG TCGAACCT GGGAGTATAA chrX:6220062-6220142 23 9.39e-05 ACGGCAGGAT TCGAACCT ACAATCTTCT chrIII:1218371-1218451 20 9.39e-05 CCAGCAGGGG TCGAACCT GCGACCTTGG chrX:9373131-9373211 34 1.24e-04 GCGAGTGGTT TCGATCCA CCGACCTCTG chrII:12678324-12678404 43 1.40e-04 AGTCTGGGGT TCGATTCC CCATACCTCC chrX:1858810-1858890 62 1.40e-04 CGGCCCGGGT TCGATTCC CGGCATGGGA chrX:6286321-6286401 53 1.40e-04 AGTCTGGGGT TCGATTCC CCATACCTCC chrV:2674005-2674085 58 1.40e-04 GGTCGCTGGT TCGATTCC AGCATGAGGC chrIV:842810-842890 52 1.40e-04 CGGCCCGGGT TCGATTCC CGGCATGGGA chrV:15554019-15554099 64 1.40e-04 CGACGCTGGT TCGATTCC AGCAGCAGG chrV:20694112-20694192 24 1.55e-04 GCACCCGGAG TTGAACCA GGGACCTCTC chrV:14855775-14855855 27 1.55e-04 GCACCCGGAG TTGAACCA GGGACCTCTC chrX:3914434-3914514 53 1.55e-04 GCAGCGGGGA TTGAACCA GAGTACGAGG chrIII:8653084-8653164 25 1.70e-04 GGTCACCAGT TCGATCCT GGTTCGGGGC chrX:16551510-16551590 55 1.70e-04 GGTCACCAGT TCGATCCT GGTTCGGGGC chrX:5407403-5407483 25 3.22e-04 CCGGTGAGGC TCGAACTC ACGACCTTCA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCGAACCC MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:10821341-10821421 1.2e-05 [+1]_72 chrII:3439401-3439481 1.2e-05 7_[+1]_65 chrX:6903116-6903196 1.2e-05 12_[+1]_60 chrII:5772915-5772995 1.2e-05 15_[+1]_57 chrIV:620473-620553 1.2e-05 62_[+1]_10 chrX:16271300-16271380 1.2e-05 10_[+1]_62 chrIV:1388206-1388286 1.2e-05 24_[+1]_48 chrII:11157798-11157878 1.2e-05 18_[+1]_54 chrX:12367644-12367724 1.2e-05 12_[+1]_60 chrV:15505185-15505265 1.2e-05 37_[+1]_35 chrX:16298322-16298402 2.6e-05 72_[+1] chrI:2410105-2410185 2.6e-05 72_[+1] chrI:9268892-9268972 2.6e-05 50_[+1]_22 chrIII:10624727-10624807 5.3e-05 29_[+1]_43 chrX:9637864-9637944 5.3e-05 2_[+1]_70 chrX:9622793-9622873 5.3e-05 45_[+1]_27 chrX:13511961-13512041 5.3e-05 23_[+1]_49 chrV:15551794-15551874 5.3e-05 19_[+1]_53 chrII:3521452-3521532 5.3e-05 49_[+1]_23 chrX:16604662-16604742 5.3e-05 72_[+1] chrV:12331954-12332034 5.3e-05 25_[+1]_47 chrX:12890264-12890344 5.3e-05 35_[+1]_37 chrIV:2801148-2801228 5.3e-05 17_[+1]_55 chrX:16602634-16602714 5.3e-05 14_[+1]_58 chrX:12843689-12843769 6.5e-05 52_[+1]_20 chrX:8386227-8386307 6.5e-05 30_[+1]_42 chrX:13781639-13781719 6.5e-05 54_[+1]_18 chrIII:6805574-6805654 6.5e-05 47_[+1]_25 chrV:19723035-19723115 6.5e-05 49_[+1]_23 chrIII:535397-535477 8e-05 49_[+1]_23 chrIV:11026146-11026226 9.4e-05 11_[+1]_61 chrX:6220062-6220142 9.4e-05 22_[+1]_50 chrIII:1218371-1218451 9.4e-05 19_[+1]_53 chrX:9373131-9373211 0.00012 33_[+1]_39 chrII:12678324-12678404 0.00014 42_[+1]_30 chrX:1858810-1858890 0.00014 61_[+1]_11 chrX:6286321-6286401 0.00014 52_[+1]_20 chrV:2674005-2674085 0.00014 57_[+1]_15 chrIV:842810-842890 0.00014 51_[+1]_21 chrV:15554019-15554099 0.00014 63_[+1]_9 chrV:20694112-20694192 0.00015 23_[+1]_49 chrV:14855775-14855855 0.00015 26_[+1]_46 chrX:3914434-3914514 0.00015 52_[+1]_20 chrIII:8653084-8653164 0.00017 24_[+1]_48 chrX:16551510-16551590 0.00017 54_[+1]_18 chrX:5407403-5407483 0.00032 24_[+1]_48 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCGAACCC MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCGAACCC width=8 seqs=46 chrX:10821341-10821421 ( 1) TCGAACCC 1 chrII:3439401-3439481 ( 8) TCGAACCC 1 chrX:6903116-6903196 ( 13) TCGAACCC 1 chrII:5772915-5772995 ( 16) TCGAACCC 1 chrIV:620473-620553 ( 63) TCGAACCC 1 chrX:16271300-16271380 ( 11) TCGAACCC 1 chrIV:1388206-1388286 ( 25) TCGAACCC 1 chrII:11157798-11157878 ( 19) TCGAACCC 1 chrX:12367644-12367724 ( 13) TCGAACCC 1 chrV:15505185-15505265 ( 38) TCGAACCC 1 chrX:16298322-16298402 ( 73) TCGATCCC 1 chrI:2410105-2410185 ( 73) TCGATCCC 1 chrI:9268892-9268972 ( 51) TCGATCCC 1 chrIII:10624727-10624807 ( 30) TCGAACCA 1 chrX:9637864-9637944 ( 3) TTGAACCC 1 chrX:9622793-9622873 ( 46) TTGAACCC 1 chrX:13511961-13512041 ( 24) TTGAACCC 1 chrV:15551794-15551874 ( 20) TTGAACCC 1 chrII:3521452-3521532 ( 50) TCGAACCA 1 chrX:16604662-16604742 ( 73) TTGAACCC 1 chrV:12331954-12332034 ( 26) TCGAACCA 1 chrX:12890264-12890344 ( 36) TTGAACCC 1 chrIV:2801148-2801228 ( 18) TTGAACCC 1 chrX:16602634-16602714 ( 15) TCGAACCA 1 chrX:12843689-12843769 ( 53) TCGAGCCC 1 chrX:8386227-8386307 ( 31) TCGAGCCC 1 chrX:13781639-13781719 ( 55) TCGAGCCC 1 chrIII:6805574-6805654 ( 48) TCGAGCCC 1 chrV:19723035-19723115 ( 50) TCGAGCCC 1 chrIII:535397-535477 ( 50) TCGAATCC 1 chrIV:11026146-11026226 ( 12) TCGAACCT 1 chrX:6220062-6220142 ( 23) TCGAACCT 1 chrIII:1218371-1218451 ( 20) TCGAACCT 1 chrX:9373131-9373211 ( 34) TCGATCCA 1 chrII:12678324-12678404 ( 43) TCGATTCC 1 chrX:1858810-1858890 ( 62) TCGATTCC 1 chrX:6286321-6286401 ( 53) TCGATTCC 1 chrV:2674005-2674085 ( 58) TCGATTCC 1 chrIV:842810-842890 ( 52) TCGATTCC 1 chrV:15554019-15554099 ( 64) TCGATTCC 1 chrV:20694112-20694192 ( 24) TTGAACCA 1 chrV:14855775-14855855 ( 27) TTGAACCA 1 chrX:3914434-3914514 ( 53) TTGAACCA 1 chrIII:8653084-8653164 ( 25) TCGATCCT 1 chrX:16551510-16551590 ( 55) TCGATCCT 1 chrX:5407403-5407483 ( 25) TCGAACTC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCGAACCC MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.03184 E= 1.4e-015 -1217 -1217 -1217 188 -1217 174 -1217 -32 -1217 -1217 202 -1217 202 -1217 -1217 -1217 135 -1217 -118 -6 -1217 186 -1217 -84 -1217 206 -1217 -364 -51 161 -1217 -132 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCGAACCC MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 46 E= 1.4e-015 0.000000 0.000000 0.000000 1.000000 0.000000 0.782609 0.000000 0.217391 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.630435 0.000000 0.108696 0.260870 0.000000 0.847826 0.000000 0.152174 0.000000 0.978261 0.000000 0.021739 0.173913 0.717391 0.000000 0.108696 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCGAACCC MEME-1 regular expression -------------------------------------------------------------------------------- T[CT]GA[AT]CCC -------------------------------------------------------------------------------- Time 9.92 secs. ******************************************************************************** ******************************************************************************** MOTIF AGTGGTTA MEME-2 width = 8 sites = 21 llr = 212 E-value = 1.2e-008 ******************************************************************************** -------------------------------------------------------------------------------- Motif AGTGGTTA MEME-2 Description -------------------------------------------------------------------------------- Simplified A a::::::9 pos.-specific C :::::::: probability G :9:aa::1 matrix T :1a::aa: bits 2.1 * ** 1.9 * **** 1.7 * ***** 1.5 ******** Relative 1.3 ******** Entropy 1.0 ******** (14.5 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AGTGGTTA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTGGTTA MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:16298322-16298402 32 1.85e-05 CTCGTGGTGT AGTGGTTA TCACATCTGT chrI:13161030-13161110 44 1.85e-05 CTCGTGGTGT AGTGGTTA TCACATCTGT chrX:5707971-5708051 70 1.85e-05 CAGGTGGCCG AGTGGTTA AGG chrX:1858810-1858890 22 1.85e-05 CATGTGGTCT AGTGGTTA GGATTCGTGG chrI:11978717-11978797 60 1.85e-05 GTTGTGGTCT AGTGGTTA GGATTTATGG chrX:12843689-12843769 12 1.85e-05 CTCGTGGTGT AGTGGTTA TCACATCTGT chrIV:620473-620553 22 1.85e-05 CCTCTGGTGT AGTGGTTA TCACGTCTGC chrI:9605739-9605819 30 1.85e-05 GCGATGTCCG AGTGGTTA AGGAGTTGGA chrX:4444229-4444309 46 1.85e-05 CATGTGGTCT AGTGGTTA GGATTCGTGG chrX:8971575-8971655 38 1.85e-05 GTCATGTCCG AGTGGTTA AGGAGATTGA chrV:53456-53536 33 1.85e-05 cgcatggccg agtggtta gtacgtatgc chrX:8646452-8646532 41 1.85e-05 CATGTGGTCT AGTGGTTA GGATTCGTGG chrII:6898170-6898250 37 1.85e-05 CATGTGGTCT AGTGGTTA GGATTCGTGG chrII:11959350-11959430 38 1.85e-05 CCTGTGGTGT AGTGGTTA TCACGTCTGC chrIV:842810-842890 12 1.85e-05 CATGTGGTCT AGTGGTTA GGATTCGTGG chrV:15554019-15554099 24 1.85e-05 TGCTTAGTAT AGTGGTTA GTACTCCACG chrII:3439401-3439481 72 3.70e-05 GGGCCCGGCA AGTGGTTG A chrII:6248649-6248729 14 3.70e-05 TCAATGGCGG AGTGGTTG TATGTGCTAT chrII:8547118-8547198 42 5.74e-05 TTTGTGGTGT ATTGGTTA ACATGTGTGT chrIII:3476305-3476385 2 5.74e-05 A ATTGGTTA TTTGGGAGAC chrX:15347868-15347948 20 7.33e-05 ATTATCCCTC AGTGGTCA GATTGTTTGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTGGTTA MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:16298322-16298402 1.9e-05 31_[+2]_41 chrI:13161030-13161110 1.9e-05 43_[+2]_29 chrX:5707971-5708051 1.9e-05 69_[+2]_3 chrX:1858810-1858890 1.9e-05 21_[+2]_51 chrI:11978717-11978797 1.9e-05 59_[+2]_13 chrX:12843689-12843769 1.9e-05 11_[+2]_61 chrIV:620473-620553 1.9e-05 21_[+2]_51 chrI:9605739-9605819 1.9e-05 29_[+2]_43 chrX:4444229-4444309 1.9e-05 45_[+2]_27 chrX:8971575-8971655 1.9e-05 37_[+2]_35 chrV:53456-53536 1.9e-05 32_[+2]_40 chrX:8646452-8646532 1.9e-05 40_[+2]_32 chrII:6898170-6898250 1.9e-05 36_[+2]_36 chrII:11959350-11959430 1.9e-05 37_[+2]_35 chrIV:842810-842890 1.9e-05 11_[+2]_61 chrV:15554019-15554099 1.9e-05 23_[+2]_49 chrII:3439401-3439481 3.7e-05 71_[+2]_1 chrII:6248649-6248729 3.7e-05 13_[+2]_59 chrII:8547118-8547198 5.7e-05 41_[+2]_31 chrIII:3476305-3476385 5.7e-05 1_[+2]_71 chrX:15347868-15347948 7.3e-05 19_[+2]_53 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTGGTTA MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AGTGGTTA width=8 seqs=21 chrX:16298322-16298402 ( 32) AGTGGTTA 1 chrI:13161030-13161110 ( 44) AGTGGTTA 1 chrX:5707971-5708051 ( 70) AGTGGTTA 1 chrX:1858810-1858890 ( 22) AGTGGTTA 1 chrI:11978717-11978797 ( 60) AGTGGTTA 1 chrX:12843689-12843769 ( 12) AGTGGTTA 1 chrIV:620473-620553 ( 22) AGTGGTTA 1 chrI:9605739-9605819 ( 30) AGTGGTTA 1 chrX:4444229-4444309 ( 46) AGTGGTTA 1 chrX:8971575-8971655 ( 38) AGTGGTTA 1 chrV:53456-53536 ( 33) AGTGGTTA 1 chrX:8646452-8646532 ( 41) AGTGGTTA 1 chrII:6898170-6898250 ( 37) AGTGGTTA 1 chrII:11959350-11959430 ( 38) AGTGGTTA 1 chrIV:842810-842890 ( 12) AGTGGTTA 1 chrV:15554019-15554099 ( 24) AGTGGTTA 1 chrII:3439401-3439481 ( 72) AGTGGTTG 1 chrII:6248649-6248729 ( 14) AGTGGTTG 1 chrII:8547118-8547198 ( 42) ATTGGTTA 1 chrIII:3476305-3476385 ( 2) ATTGGTTA 1 chrX:15347868-15347948 ( 20) AGTGGTCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTGGTTA MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.0668 E= 1.2e-008 202 -1104 -1104 -1104 -1104 -1104 187 -151 -1104 -1104 -1104 188 -1104 -1104 202 -1104 -1104 -1104 202 -1104 -1104 -1104 -1104 188 -1104 -230 -1104 181 187 -1104 -137 -1104 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTGGTTA MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 21 E= 1.2e-008 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.904762 0.095238 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.047619 0.000000 0.952381 0.904762 0.000000 0.095238 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTGGTTA MEME-2 regular expression -------------------------------------------------------------------------------- AGTGGTTA -------------------------------------------------------------------------------- Time 13.83 secs. ******************************************************************************** ******************************************************************************** MOTIF CTGAGCTA MEME-3 width = 8 sites = 21 llr = 201 E-value = 6.3e-004 ******************************************************************************** -------------------------------------------------------------------------------- Motif CTGAGCTA MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::8:::a pos.-specific C a::2:a3: probability G :1a:a::: matrix T :9::::7: bits 2.1 * * ** 1.9 * * ** 1.7 * * ** * 1.5 *** ** * Relative 1.3 ****** * Entropy 1.0 ******** (13.8 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CTGAGCTA consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTGAGCTA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:9637864-9637944 45 1.51e-05 CGCTCTACCA CTGAGCTA TACCCCCGCA chrII:3439401-3439481 51 1.51e-05 GCTCTACCGA CTGAGCTA ACCGGGCCCG chrI:13310388-13310468 14 1.51e-05 CGCTCTACCA CTGAGCTA TAAGGGCTGC chrX:11935087-11935167 50 1.51e-05 CGCTCTGCCA CTGAGCTA TACGGGCTAC chrV:20694112-20694192 66 1.51e-05 TGCTCTGCCA CTGAGCTA TACCCCC chrIV:14013824-14013904 38 1.51e-05 CGCTCTACCC CTGAGCTA TACCCCCGGA chrV:14876399-14876479 48 1.51e-05 GCTCTCCCAA CTGAGCTA TCGAGGCCGA chrX:13415146-13415226 33 1.51e-05 CTCTAACCGA CTGAGCTA TGGCGGCTGA chrIII:1218371-1218451 64 1.51e-05 CTCTAACCGA CTGAGCTA TGGCGGCAC chrII:11157798-11157878 62 1.51e-05 GCTCTACCGA CTGAGCTA ACCGGGCAGC chrV:14855775-14855855 69 1.51e-05 TGCTCTGCCA CTGAGCTA TACC chrIII:10624727-10624807 72 2.81e-05 CGCTCTGCCA CTGAGCCA A chrIII:7030598-7030678 16 2.81e-05 CGCTCTGCCA CTGAGCCA ATGAGGCGGA chrIV:605541-605621 4 2.81e-05 GAG CTGAGCCA GCAGGAGCCG chrX:5407403-5407483 68 4.23e-05 GCGCTGCCTA CTGCGCTA CGGAA chrV:4731567-4731647 55 5.60e-05 TGCATGTAGG CGGAGCTA ACGATTTTTC chrII:8325298-8325378 16 5.60e-05 TGTGAGGAGG CGGAGCTA CTTTTGAAAT chrIV:9477721-9477801 36 6.83e-05 CTTTTACCAC CTGCGCCA TGCGGGCATA chrII:4942495-4942575 73 6.83e-05 CGCGTTACCA CTGCGCCA chrI:12225451-12225531 32 6.83e-05 CACGCTTCCA CTGCGCCA CGCTGCTGCG chrX:12693530-12693610 48 9.44e-05 ATTATCTCAA CTGAGCTC TAGAATGTTA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTGAGCTA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:9637864-9637944 1.5e-05 44_[+3]_28 chrII:3439401-3439481 1.5e-05 50_[+3]_22 chrI:13310388-13310468 1.5e-05 13_[+3]_59 chrX:11935087-11935167 1.5e-05 49_[+3]_23 chrV:20694112-20694192 1.5e-05 65_[+3]_7 chrIV:14013824-14013904 1.5e-05 37_[+3]_35 chrV:14876399-14876479 1.5e-05 47_[+3]_25 chrX:13415146-13415226 1.5e-05 32_[+3]_40 chrIII:1218371-1218451 1.5e-05 63_[+3]_9 chrII:11157798-11157878 1.5e-05 61_[+3]_11 chrV:14855775-14855855 1.5e-05 68_[+3]_4 chrIII:10624727-10624807 2.8e-05 71_[+3]_1 chrIII:7030598-7030678 2.8e-05 15_[+3]_57 chrIV:605541-605621 2.8e-05 3_[+3]_69 chrX:5407403-5407483 4.2e-05 67_[+3]_5 chrV:4731567-4731647 5.6e-05 54_[+3]_18 chrII:8325298-8325378 5.6e-05 15_[+3]_57 chrIV:9477721-9477801 6.8e-05 35_[+3]_37 chrII:4942495-4942575 6.8e-05 72_[+3] chrI:12225451-12225531 6.8e-05 31_[+3]_41 chrX:12693530-12693610 9.4e-05 47_[+3]_25 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTGAGCTA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CTGAGCTA width=8 seqs=21 chrX:9637864-9637944 ( 45) CTGAGCTA 1 chrII:3439401-3439481 ( 51) CTGAGCTA 1 chrI:13310388-13310468 ( 14) CTGAGCTA 1 chrX:11935087-11935167 ( 50) CTGAGCTA 1 chrV:20694112-20694192 ( 66) CTGAGCTA 1 chrIV:14013824-14013904 ( 38) CTGAGCTA 1 chrV:14876399-14876479 ( 48) CTGAGCTA 1 chrX:13415146-13415226 ( 33) CTGAGCTA 1 chrIII:1218371-1218451 ( 64) CTGAGCTA 1 chrII:11157798-11157878 ( 62) CTGAGCTA 1 chrV:14855775-14855855 ( 69) CTGAGCTA 1 chrIII:10624727-10624807 ( 72) CTGAGCCA 1 chrIII:7030598-7030678 ( 16) CTGAGCCA 1 chrIV:605541-605621 ( 4) CTGAGCCA 1 chrX:5407403-5407483 ( 68) CTGCGCTA 1 chrV:4731567-4731647 ( 55) CGGAGCTA 1 chrII:8325298-8325378 ( 16) CGGAGCTA 1 chrIV:9477721-9477801 ( 36) CTGCGCCA 1 chrII:4942495-4942575 ( 73) CTGCGCCA 1 chrI:12225451-12225531 ( 32) CTGCGCCA 1 chrX:12693530-12693610 ( 48) CTGAGCTC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTGAGCTA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.0668 E= 6.3e-004 -1104 209 -1104 -1104 -1104 -1104 -137 174 -1104 -1104 202 -1104 171 -30 -1104 -1104 -1104 -1104 202 -1104 -1104 209 -1104 -1104 -1104 29 -1104 139 195 -230 -1104 -1104 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTGAGCTA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 21 E= 6.3e-004 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.095238 0.904762 0.000000 0.000000 1.000000 0.000000 0.809524 0.190476 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.285714 0.000000 0.714286 0.952381 0.047619 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTGAGCTA MEME-3 regular expression -------------------------------------------------------------------------------- CTGAGC[TC]A -------------------------------------------------------------------------------- Time 17.50 secs. ******************************************************************************** ******************************************************************************** MOTIF ACCCMCGC MEME-4 width = 8 sites = 12 llr = 130 E-value = 1.8e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif ACCCMCGC MEME-4 Description -------------------------------------------------------------------------------- Simplified A a:::7::: pos.-specific C :aaa3a:a probability G ::::::a: matrix T :::::::: bits 2.1 **** *** 1.9 **** *** 1.7 **** *** 1.5 **** *** Relative 1.3 **** *** Entropy 1.0 ******** (15.6 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel ACCCACGC consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCCMCGC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:1858810-1858890 45 1.06e-05 CGTGGTTTTC ACCCACGC GGCCCGGGTT chrII:14635353-14635433 1 1.06e-05 . ACCCACGC CCCCGAAGGG chrX:4444229-4444309 69 1.06e-05 CGTGGTTTTC ACCCACGC GGCC chrX:8646452-8646532 64 1.06e-05 CGTGGTTTTC ACCCACGC GGCCCGGGT chrII:6898170-6898250 60 1.06e-05 CGTGGTTTTC ACCCACGC GGCCCGGGTT chrX:13415146-13415226 16 1.06e-05 GGCTTATTAG ACCCACGC TCTAACCGAC chrIII:1218371-1218451 47 1.06e-05 GGCTTATTAG ACCCACGC TCTAACCGAC chrIV:842810-842890 35 1.06e-05 CGTGGTTTTC ACCCACGC GGCCCGGGTT chrX:9637864-9637944 54 2.06e-05 ACTGAGCTAT ACCCCCGC ACAGTGAAAC chrII:6248649-6248729 56 2.06e-05 TGTAGGTTCG ACCCCCGC TTTACTGCGT chrV:7231015-7231095 17 2.06e-05 AGGAGTCGCA ACCCCCGC GCACTTTTTA chrI:1575654-1575734 10 2.06e-05 ATAACCAGA ACCCCCGC AGCGCACACA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCCMCGC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:1858810-1858890 1.1e-05 44_[+4]_28 chrII:14635353-14635433 1.1e-05 [+4]_72 chrX:4444229-4444309 1.1e-05 68_[+4]_4 chrX:8646452-8646532 1.1e-05 63_[+4]_9 chrII:6898170-6898250 1.1e-05 59_[+4]_13 chrX:13415146-13415226 1.1e-05 15_[+4]_57 chrIII:1218371-1218451 1.1e-05 46_[+4]_26 chrIV:842810-842890 1.1e-05 34_[+4]_38 chrX:9637864-9637944 2.1e-05 53_[+4]_19 chrII:6248649-6248729 2.1e-05 55_[+4]_17 chrV:7231015-7231095 2.1e-05 16_[+4]_56 chrI:1575654-1575734 2.1e-05 9_[+4]_63 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCCMCGC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ACCCMCGC width=8 seqs=12 chrX:1858810-1858890 ( 45) ACCCACGC 1 chrII:14635353-14635433 ( 1) ACCCACGC 1 chrX:4444229-4444309 ( 69) ACCCACGC 1 chrX:8646452-8646532 ( 64) ACCCACGC 1 chrII:6898170-6898250 ( 60) ACCCACGC 1 chrX:13415146-13415226 ( 16) ACCCACGC 1 chrIII:1218371-1218451 ( 47) ACCCACGC 1 chrIV:842810-842890 ( 35) ACCCACGC 1 chrX:9637864-9637944 ( 54) ACCCCCGC 1 chrII:6248649-6248729 ( 56) ACCCCCGC 1 chrV:7231015-7231095 ( 17) ACCCCCGC 1 chrI:1575654-1575734 ( 10) ACCCCCGC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCCMCGC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.0174 E= 1.8e-002 202 -1023 -1023 -1023 -1023 209 -1023 -1023 -1023 209 -1023 -1023 -1023 209 -1023 -1023 143 51 -1023 -1023 -1023 209 -1023 -1023 -1023 -1023 202 -1023 -1023 209 -1023 -1023 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCCMCGC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 12 E= 1.8e-002 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.666667 0.333333 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCCMCGC MEME-4 regular expression -------------------------------------------------------------------------------- ACCC[AC]CGC -------------------------------------------------------------------------------- Time 21.13 secs. ******************************************************************************** ******************************************************************************** MOTIF ACCACTMG MEME-5 width = 8 sites = 18 llr = 173 E-value = 3.7e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif ACCACTMG MEME-5 Description -------------------------------------------------------------------------------- Simplified A a::6::4: pos.-specific C :aa:a:6: probability G :::2:::a matrix T :::2:a:: bits 2.1 *** * * 1.9 *** ** * 1.7 *** ** * 1.5 *** ** * Relative 1.3 *** ** * Entropy 1.0 *** **** (13.9 bits) 0.8 *** **** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel ACCACTCG consensus T A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCACTMG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrV:12596963-12597043 70 1.23e-05 TGAGGACACA ACCACTCG GCC chrII:5772915-5772995 66 1.23e-05 CAACGCCTTA ACCACTCG GCCATCG chrV:12780414-12780494 35 1.23e-05 CAACTCCTTA ACCACTCG GACATCGCAG chrIII:1604732-1604812 23 2.53e-05 ATAAATCCTA ACCACTAG ACCACAACGG chrX:13511961-13512041 62 2.53e-05 CGAGAATCAT ACCACTAG ACCATTCGGC chrX:10821341-10821421 39 2.53e-05 ACGAATCCTA ACCACTAG ACCACATGGG chrX:16271300-16271380 49 2.53e-05 ATAAATCCTA ACCACTAG ACCACAACGG chrIV:1388206-1388286 63 2.53e-05 ACGAATCCTA ACCACTAG ACCACATGGG chrI:8530145-8530225 36 2.53e-05 ATAAATCCTA ACCACTAG ACCACAACGG chrIV:2639812-2639892 50 2.53e-05 ACGAATCCTA ACCACTAG ACCACATAGG chrX:12367644-12367724 51 2.53e-05 ACGAATCCTA ACCACTAG ACCACATGGG chrV:20694112-20694192 35 3.88e-05 TGAACCAGGG ACCTCTCG ATCTGCAGTC chrI:9268892-9268972 62 3.88e-05 CGATCCCGGG ACCTCTCG CACCCTAAGC chrV:14855775-14855855 38 3.88e-05 TGAACCAGGG ACCTCTCG ATCTGCAGTC chrIII:8650404-8650484 3 3.88e-05 GG ACCTCTCG CACCCGAAGC chrX:6903116-6903196 61 6.54e-05 AGCGCCTTAG ACCGCTCG GCCATCTCTC chrII:14635353-14635433 45 6.54e-05 AGCGCCTTAG ACCGCTCG GCCATCTCAC chrI:6051192-6051272 26 6.54e-05 AGCGCCTTGG ACCGCTCG GCCATCTCTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCACTMG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrV:12596963-12597043 1.2e-05 69_[+5]_3 chrII:5772915-5772995 1.2e-05 65_[+5]_7 chrV:12780414-12780494 1.2e-05 34_[+5]_38 chrIII:1604732-1604812 2.5e-05 22_[+5]_50 chrX:13511961-13512041 2.5e-05 61_[+5]_11 chrX:10821341-10821421 2.5e-05 38_[+5]_34 chrX:16271300-16271380 2.5e-05 48_[+5]_24 chrIV:1388206-1388286 2.5e-05 62_[+5]_10 chrI:8530145-8530225 2.5e-05 35_[+5]_37 chrIV:2639812-2639892 2.5e-05 49_[+5]_23 chrX:12367644-12367724 2.5e-05 50_[+5]_22 chrV:20694112-20694192 3.9e-05 34_[+5]_38 chrI:9268892-9268972 3.9e-05 61_[+5]_11 chrV:14855775-14855855 3.9e-05 37_[+5]_35 chrIII:8650404-8650484 3.9e-05 2_[+5]_70 chrX:6903116-6903196 6.5e-05 60_[+5]_12 chrII:14635353-14635433 6.5e-05 44_[+5]_28 chrI:6051192-6051272 6.5e-05 25_[+5]_47 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCACTMG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ACCACTMG width=8 seqs=18 chrV:12596963-12597043 ( 70) ACCACTCG 1 chrII:5772915-5772995 ( 66) ACCACTCG 1 chrV:12780414-12780494 ( 35) ACCACTCG 1 chrIII:1604732-1604812 ( 23) ACCACTAG 1 chrX:13511961-13512041 ( 62) ACCACTAG 1 chrX:10821341-10821421 ( 39) ACCACTAG 1 chrX:16271300-16271380 ( 49) ACCACTAG 1 chrIV:1388206-1388286 ( 63) ACCACTAG 1 chrI:8530145-8530225 ( 36) ACCACTAG 1 chrIV:2639812-2639892 ( 50) ACCACTAG 1 chrX:12367644-12367724 ( 51) ACCACTAG 1 chrV:20694112-20694192 ( 35) ACCTCTCG 1 chrI:9268892-9268972 ( 62) ACCTCTCG 1 chrV:14855775-14855855 ( 38) ACCTCTCG 1 chrIII:8650404-8650484 ( 3) ACCTCTCG 1 chrX:6903116-6903196 ( 61) ACCGCTCG 1 chrII:14635353-14635433 ( 45) ACCGCTCG 1 chrI:6051192-6051272 ( 26) ACCGCTCG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCACTMG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.8329 E= 3.7e-001 202 -1081 -1081 -1081 -1081 209 -1081 -1081 -1081 209 -1081 -1081 131 -1081 -57 -29 -1081 209 -1081 -1081 -1081 -1081 -1081 188 85 125 -1081 -1081 -1081 -1081 202 -1081 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCACTMG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 18 E= 3.7e-001 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.611111 0.000000 0.166667 0.222222 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.444444 0.555556 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACCACTMG MEME-5 regular expression -------------------------------------------------------------------------------- ACC[AT]CT[CA]G -------------------------------------------------------------------------------- Time 24.75 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrM:148-228 9.12e-01 80 chrM:5503-5583 9.78e-01 80 chrV:265404-265484 6.35e-01 80 chrM:5726-5806 8.80e-01 80 chrII:2570633-2570713 9.99e-01 80 chrM:10796-10876 8.31e-01 80 chrI:933477-933557 9.02e-01 80 chrX:5056377-5056457 9.51e-01 80 chrM:3590-3670 9.18e-01 80 chrM:9391-9471 5.81e-01 80 chrM:2972-3052 6.35e-01 80 chrM:9982-10062 1.03e-01 80 chrIII:3500001-3500081 3.56e-01 80 chrV:4647941-4648021 7.93e-01 80 chrX:16944402-16944482 1.00e+00 80 chrV:16699860-16699940 1.00e+00 80 chrX:8156111-8156191 9.48e-01 80 chrM:7047-7127 8.50e-01 80 chrX:12693330-12693410 1.89e-01 80 chrX:13145005-13145085 9.99e-01 80 chrM:1309-1389 9.92e-01 80 chrIV:1377769-1377849 1.18e-01 80 chrM:7252-7332 5.85e-01 80 chrIII:931565-931645 9.20e-01 80 chrX:16602634-16602714 1.57e-03 14_[+1(5.31e-05)]_58 chrX:8944253-8944333 5.11e-02 80 chrM:8336-8416 9.59e-01 80 chrI:3248554-3248634 9.88e-01 80 chrV:19723035-19723115 1.23e-02 49_[+1(6.54e-05)]_23 chrX:14229608-14229688 9.97e-01 80 chrV:14689503-14689583 9.20e-01 80 chrM:7604-7684 8.74e-01 80 chrII:5399363-5399443 1.92e-01 80 chrX:11798195-11798275 4.63e-01 80 chrIII:6805574-6805654 1.23e-02 47_[+1(6.54e-05)]_25 chrII:11974751-11974831 2.31e-01 80 chrV:15554019-15554099 7.17e-03 23_[+2(1.85e-05)]_49 chrIII:3476305-3476385 8.25e-02 1_[+2(5.74e-05)]_71 chrI:1575654-1575734 9.49e-02 9_[+4(2.06e-05)]_63 chrIV:11605032-11605112 9.96e-01 80 chrM:2147-2227 8.00e-01 80 chrII:4130414-4130494 1.00e+00 80 chrV:12510026-12510106 1.00e+00 80 chrIII:8650404-8650484 3.52e-02 2_[+5(3.88e-05)]_19_[+5(6.54e-05)]_\ 43 chrX:7651479-7651559 1.13e-01 80 chrII:15218082-15218162 3.99e-01 80 chrV:15505185-15505265 2.07e-02 37_[+1(1.23e-05)]_35 chrV:3587753-3587833 6.63e-01 80 chrIV:842810-842890 1.42e-05 11_[+2(1.85e-05)]_15_[+4(1.06e-05)]_\ 38 chrM:4617-4697 5.65e-01 80 chrIII:5769852-5769932 9.76e-01 80 chrV:13176485-13176565 3.48e-01 80 chrX:8925593-8925673 9.40e-02 80 chrII:5293363-5293443 8.91e-01 80 chrV:2674005-2674085 2.18e-01 80 chrII:8325298-8325378 7.13e-02 15_[+3(5.60e-05)]_57 chrIV:605541-605621 1.20e-02 3_[+3(2.81e-05)]_69 chrIV:5334738-5334818 2.50e-01 80 chrIII:1824689-1824769 1.75e-01 80 chrM:11041-11121 8.20e-01 80 chrII:6721730-6721810 9.48e-01 80 chrV:16553069-16553149 9.22e-01 80 chrV:7231015-7231095 3.05e-02 16_[+4(2.06e-05)]_56 chrM:9180-9260 9.98e-01 80 chrII:3567694-3567774 6.46e-01 80 chrX:15347868-15347948 1.38e-01 19_[+2(7.33e-05)]_53 chrIII:3664388-3664468 8.13e-01 80 chrIII:13713155-13713235 5.48e-01 80 chrII:7001604-7001684 5.14e-01 80 chrIV:1981123-1981203 5.71e-01 80 chrX:3914434-3914514 2.22e-01 80 chrI:1740964-1741044 9.48e-01 80 chrII:4238083-4238163 3.50e-01 80 chrX:3348076-3348156 1.02e-01 80 chrV:14855775-14855855 6.05e-05 37_[+5(3.88e-05)]_23_[+3(1.51e-05)]_\ 4 chrIII:1122425-1122505 6.43e-01 80 chrIII:4426731-4426811 8.66e-01 80 chrX:8969660-8969740 4.11e-01 80 chrIII:10856982-10857062 8.86e-01 80 chrIV:11594148-11594228 5.62e-01 80 chrX:12367644-12367724 2.28e-04 12_[+1(1.23e-05)]_30_[+5(2.53e-05)]_\ 22 chrII:11959350-11959430 7.87e-02 37_[+2(1.85e-05)]_35 chrX:9102361-9102441 2.84e-01 80 chrIII:13780924-13781004 7.60e-01 80 chrV:1821467-1821547 5.65e-01 80 chrIII:13072032-13072112 2.57e-01 80 chrIV:15289689-15289769 3.84e-01 80 chrV:20832803-20832883 1.38e-01 80 chrX:5140202-5140282 6.38e-01 80 chrX:12693530-12693610 4.40e-02 47_[+3(9.44e-05)]_25 chrIV:2639812-2639892 1.22e-02 49_[+5(2.53e-05)]_23 chrIII:3175146-3175226 6.68e-01 80 chrIV:9316170-9316250 6.16e-01 80 chrM:1100-1180 6.60e-01 80 chrIII:1940069-1940149 9.30e-01 80 chrII:11157798-11157878 1.09e-04 18_[+1(1.23e-05)]_35_[+3(1.51e-05)]_\ 11 chrM:12415-12495 5.63e-01 80 chrX:6286321-6286401 5.51e-02 80 chrI:6135783-6135863 4.56e-01 80 chrX:13781639-13781719 1.24e-02 54_[+1(6.54e-05)]_18 chrIV:14576644-14576724 3.73e-01 80 chrI:6051192-6051272 1.10e-02 25_[+5(6.54e-05)]_47 chrIV:9906185-9906265 7.22e-01 80 chrIV:11688012-11688092 1.00e+00 80 chrI:12225451-12225531 1.48e-02 31_[+3(6.83e-05)]_41 chrI:9268892-9268972 2.63e-04 50_[+1(2.58e-05)]_3_[+5(3.88e-05)]_\ 11 chrX:5336739-5336819 2.54e-01 80 chrX:9373131-9373211 3.86e-03 80 chrIV:2801148-2801228 1.68e-02 17_[+1(5.31e-05)]_55 chrV:9293521-9293601 3.75e-01 80 chrI:8530145-8530225 9.81e-03 35_[+5(2.53e-05)]_37 chrIII:1218371-1218451 5.21e-06 19_[+1(9.39e-05)]_19_[+4(1.06e-05)]_\ 9_[+3(1.51e-05)]_9 chrX:12890264-12890344 2.70e-02 35_[+1(5.31e-05)]_37 chrX:13415146-13415226 3.82e-04 15_[+4(1.06e-05)]_9_[+3(1.51e-05)]_\ 40 chrI:5312803-5312883 2.96e-01 80 chrI:853259-853339 5.56e-01 80 chrX:16551510-16551590 4.37e-01 80 chrX:8638926-8639006 7.51e-01 80 chrII:7679525-7679605 8.07e-01 80 chrIV:16863646-16863726 8.64e-01 80 chrX:9296723-9296803 4.31e-01 80 chrIII:8250400-8250480 3.52e-01 80 chrIII:12399871-12399951 2.00e-01 80 chrIII:12368828-12368908 7.16e-01 80 chrIII:640555-640635 8.99e-01 80 chrV:14876399-14876479 1.80e-03 47_[+3(1.51e-05)]_25 chrII:6898170-6898250 3.87e-04 36_[+2(1.85e-05)]_15_[+4(1.06e-05)]_\ 13 chrX:14115660-14115740 6.17e-01 80 chrV:1875697-1875777 6.30e-01 80 chrI:3567635-3567715 8.92e-01 80 chrV:5275164-5275244 9.59e-01 80 chrII:7708740-7708820 2.36e-01 80 chrIV:14013824-14013904 4.26e-04 37_[+3(1.51e-05)]_35 chrX:8646452-8646532 4.57e-04 40_[+2(1.85e-05)]_15_[+4(1.06e-05)]_\ 9 chrI:13421225-13421305 7.23e-01 80 chrX:6220062-6220142 1.55e-02 22_[+1(9.39e-05)]_50 chrV:4143338-4143418 8.04e-01 80 chrX:5407403-5407483 6.75e-03 67_[+3(4.23e-05)]_5 chrIII:7030598-7030678 3.47e-02 15_[+3(2.81e-05)]_57 chrX:13653726-13653806 3.83e-01 80 chrIII:12598854-12598934 9.28e-01 80 chrIII:10094794-10094874 8.05e-01 80 chrIII:13225215-13225295 5.44e-01 80 chrIII:11091891-11091971 9.57e-01 80 chrIII:10432277-10432357 6.47e-02 80 chrV:5284760-5284840 9.39e-01 80 chrI:10807272-10807352 9.86e-01 80 chrX:14804848-14804928 4.40e-01 80 chrV:12331954-12332034 1.10e-02 25_[+1(5.31e-05)]_47 chrX:8156312-8156392 9.66e-01 80 chrX:5319346-5319426 5.13e-01 80 chrX:16604662-16604742 3.98e-02 72_[+1(5.31e-05)] chrII:6827505-6827585 6.39e-01 80 chrIII:8106637-8106717 3.42e-01 80 chrI:1271215-1271295 3.97e-02 80 chrIII:4426933-4427013 5.74e-01 80 chrI:6532062-6532142 6.77e-01 80 chrX:8386227-8386307 4.63e-02 30_[+1(6.54e-05)]_42 chrV:53456-53536 4.27e-02 32_[+2(1.85e-05)]_40 chrIII:11236953-11237033 4.86e-01 80 chrV:4615965-4616045 9.63e-01 80 chrIV:1388206-1388286 2.28e-04 24_[+1(1.23e-05)]_30_[+5(2.53e-05)]_\ 10 chrI:1823193-1823273 6.94e-01 80 chrI:1444096-1444176 7.11e-01 80 chrV:13962165-13962245 2.02e-01 80 chrX:16928294-16928374 3.50e-02 80 chrI:1415942-1416022 8.52e-01 80 chrX:8971575-8971655 1.00e-01 37_[+2(1.85e-05)]_35 chrX:4444229-4444309 1.50e-04 45_[+2(1.85e-05)]_15_[+4(1.06e-05)]_\ 4 chrII:5836599-5836679 7.67e-01 80 chrI:1175832-1175912 8.15e-01 80 chrX:16271300-16271380 5.98e-05 10_[+1(1.23e-05)]_30_[+5(2.53e-05)]_\ 24 chrIV:3232990-3233070 3.47e-01 80 chrIII:6133576-6133656 1.00e+00 80 chrI:9605739-9605819 6.30e-02 29_[+2(1.85e-05)]_43 chrI:4633642-4633722 7.68e-01 80 chrV:4731567-4731647 3.87e-02 54_[+3(5.60e-05)]_18 chrV:20694112-20694192 6.05e-05 34_[+5(3.88e-05)]_23_[+3(1.51e-05)]_\ 7 chrV:9583088-9583168 5.70e-01 80 chrV:12780414-12780494 9.46e-03 34_[+5(1.23e-05)]_38 chrIV:620473-620553 1.88e-04 21_[+2(1.85e-05)]_33_[+1(1.23e-05)]_\ 10 chrII:10169609-10169689 9.98e-01 80 chrII:14143938-14144018 7.34e-01 80 chrI:13434729-13434809 8.32e-01 80 chrIII:535397-535477 1.58e-01 49_[+1(7.97e-05)]_23 chrX:12843689-12843769 1.67e-03 11_[+2(1.85e-05)]_33_[+1(6.54e-05)]_\ 20 chrII:3521452-3521532 5.46e-02 49_[+1(5.31e-05)]_23 chrV:11933422-11933502 9.56e-01 80 chrI:11978717-11978797 4.57e-02 59_[+2(1.85e-05)]_13 chrIII:8971697-8971777 9.96e-01 80 chrIV:9191327-9191407 5.17e-01 80 chrII:10303919-10303999 6.40e-01 80 chrI:3873945-3874025 9.32e-01 80 chrIII:3476504-3476584 6.76e-01 80 chrI:14721619-14721699 8.76e-01 80 chrII:5772915-5772995 1.72e-05 15_[+1(1.23e-05)]_42_[+5(1.23e-05)]_\ 7 chrII:4942495-4942575 1.98e-02 72_[+3(6.83e-05)] chrV:5592425-5592505 9.90e-01 80 chrX:9078313-9078393 8.81e-01 80 chrX:1837850-1837930 3.52e-01 80 chrX:11935087-11935167 1.51e-02 49_[+3(1.51e-05)]_23 chrII:9566213-9566293 3.38e-01 80 chrIII:8768061-8768141 7.22e-01 80 chrV:11239339-11239419 3.31e-01 80 chrII:14635353-14635433 8.01e-04 [+4(1.06e-05)]_36_[+5(6.54e-05)]_28 chrX:1858810-1858890 1.42e-05 21_[+2(1.85e-05)]_15_[+4(1.06e-05)]_\ 28 chrII:14063177-14063257 9.98e-01 80 chrII:8547118-8547198 9.18e-02 41_[+2(5.74e-05)]_31 chrIV:796681-796761 9.97e-01 80 chrII:6248649-6248729 2.17e-04 13_[+2(3.70e-05)]_34_[+4(2.06e-05)]_\ 17 chrX:5707971-5708051 5.72e-02 69_[+2(1.85e-05)]_3 chrIII:8653084-8653164 3.29e-01 80 chrI:13310388-13310468 1.96e-02 13_[+3(1.51e-05)]_59 chrX:6903116-6903196 9.75e-06 16_[+4(1.06e-05)]_36_[+5(6.54e-05)]_\ 12 chrIII:4414247-4414327 9.90e-01 80 chrIV:11026146-11026226 1.34e-01 11_[+1(9.39e-05)]_61 chrI:14756774-14756854 2.52e-01 80 chrI:1070004-1070084 2.72e-01 80 chrX:11467486-11467566 1.22e-01 80 chrV:15551794-15551874 1.68e-02 19_[+1(5.31e-05)]_53 chrII:3439401-3439481 8.94e-07 7_[+1(1.23e-05)]_35_[+3(1.51e-05)]_\ 13_[+2(3.70e-05)]_1 chrIV:9477721-9477801 1.26e-02 35_[+3(6.83e-05)]_37 chrII:12042369-12042449 6.26e-01 80 chrV:11113308-11113388 8.51e-01 80 chrX:15173641-15173721 9.66e-01 80 chrX:10821341-10821421 1.90e-04 [+1(1.23e-05)]_30_[+5(2.53e-05)]_34 chrX:13511961-13512041 2.98e-03 23_[+1(5.31e-05)]_3_[+5(3.88e-05)]_\ 19_[+5(2.53e-05)]_11 chrI:7095010-7095090 5.58e-01 80 chrIII:4171147-4171227 8.05e-01 80 chrIII:5305857-5305937 2.49e-02 80 chrI:7472518-7472598 4.48e-01 80 chrI:2410105-2410185 3.80e-03 72_[+1(2.58e-05)] chrIII:4568694-4568774 3.26e-01 80 chrX:10963770-10963850 5.17e-01 80 chrII:12678324-12678404 5.51e-02 80 chrIII:1604732-1604812 4.25e-02 22_[+5(2.53e-05)]_50 chrV:6888990-6889070 2.16e-01 80 chrI:13161030-13161110 6.84e-02 43_[+2(1.85e-05)]_29 chrV:12596963-12597043 2.01e-02 69_[+5(1.23e-05)]_3 chrIII:3916787-3916867 3.15e-01 80 chrX:9091546-9091626 1.31e-01 80 chrV:10040010-10040090 9.61e-01 80 chrX:6371317-6371397 4.82e-01 80 chrX:9622793-9622873 2.32e-02 45_[+1(5.31e-05)]_27 chrI:1958529-1958609 9.56e-01 80 chrX:9637864-9637944 5.61e-07 2_[+1(5.31e-05)]_34_[+3(1.51e-05)]_\ 1_[+4(2.06e-05)]_19 chrX:16298322-16298402 1.48e-03 31_[+2(1.85e-05)]_33_[+1(2.58e-05)] chrII:7756968-7757048 3.55e-01 80 chrIII:10624727-10624807 1.79e-03 29_[+1(5.31e-05)]_34_[+3(2.81e-05)]_\ 1 chrIII:1601590-1601670 1.24e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c27n08.farnam.hpc.yale.internal ********************************************************************************