******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/ZNF407.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr15:32907272-32907352 1.0000 80 chr2:211342321-211342401 1.0000 80 chrX:51486373-51486453 1.0000 80 chr17:30668236-30668316 1.0000 80 chr13:43597680-43597760 1.0000 80 chr9:88419957-88420037 1.0000 80 chr2:219151548-219151628 1.0000 80 chr6:52020031-52020111 1.0000 80 chr2:56346596-56346676 1.0000 80 chr19:39042195-39042275 1.0000 80 chr12:118813277-11881335 1.0000 80 chr11:8350532-8350612 1.0000 80 chr2:9286013-9286093 1.0000 80 chrX:148713516-148713596 1.0000 80 chr9:68726380-68726460 1.0000 80 chr1:202523993-202524073 1.0000 80 chr14:59113325-59113405 1.0000 80 chr16:449017-449097 1.0000 80 chr8:29172460-29172540 1.0000 80 chr1:14128463-14128543 1.0000 80 chr13:42529807-42529887 1.0000 80 chr15:31115774-31115854 1.0000 80 chr14:39901931-39902011 1.0000 80 chr6:161735752-161735832 1.0000 80 chr16:53536953-53537033 1.0000 80 chr22:42394790-42394870 1.0000 80 chr9:69065412-69065492 1.0000 80 chr18:44702668-44702748 1.0000 80 chr9:138904147-138904227 1.0000 80 chr1:22546132-22546212 1.0000 80 chr22:31608284-31608364 1.0000 80 chr3:72846955-72847035 1.0000 80 chr8:9911641-9911721 1.0000 80 chr11:34805739-34805819 1.0000 80 chr9:115265557-115265637 1.0000 80 chr6:79577217-79577297 1.0000 80 chr1:183204824-183204904 1.0000 80 chr14:54976518-54976598 1.0000 80 chr2:128343589-128343669 1.0000 80 chr2:191325468-191325548 1.0000 80 chr9:86432914-86432994 1.0000 80 chr14:53620201-53620281 1.0000 80 chr17:62084521-62084601 1.0000 80 chr2:219906260-219906340 1.0000 80 chr17:9479170-9479250 1.0000 80 chr15:88558636-88558716 1.0000 80 chr8:638398-638478 1.0000 80 chr2:176940285-176940365 1.0000 80 chr16:28543582-28543662 1.0000 80 chrX:120490541-120490621 1.0000 80 chr21:34145004-34145084 1.0000 80 chr10:30638343-30638423 1.0000 80 chrX:118320937-118321017 1.0000 80 chr15:30917909-30917989 1.0000 80 chr1:17093231-17093311 1.0000 80 chr6:2766665-2766745 1.0000 80 chr14:56643301-56643381 1.0000 80 chr12:4714032-4714112 1.0000 80 chr2:207479680-207479760 1.0000 80 chr2:47142760-47142840 1.0000 80 chr19:37997944-37998024 1.0000 80 chr12:125354107-12535418 1.0000 80 chr5:86563987-86564067 1.0000 80 chr3:49840769-49840849 1.0000 80 chr22:32808268-32808348 1.0000 80 chr20:3828168-3828248 1.0000 80 chr2:203776884-203776964 1.0000 80 chr2:191290148-191290228 1.0000 80 chr7:31174315-31174395 1.0000 80 chr8:71504842-71504922 1.0000 80 chr5:132528467-132528547 1.0000 80 chr6:160351040-160351120 1.0000 80 chr2:111489941-111490021 1.0000 80 chr1:185862014-185862094 1.0000 80 chr2:47210481-47210561 1.0000 80 chr1:71511505-71511585 1.0000 80 chrX:2511599-2511679 1.0000 80 chr2:48287240-48287320 1.0000 80 chr12:12344112-12344192 1.0000 80 chr10:29421364-29421444 1.0000 80 chr2:105678189-105678269 1.0000 80 chr5:178450663-178450743 1.0000 80 chr19:14224999-14225079 1.0000 80 chr4:1723684-1723764 1.0000 80 chr1:145516240-145516320 1.0000 80 chr18:18691486-18691566 1.0000 80 chr7:916749-916829 1.0000 80 chr7:67981985-67982065 1.0000 80 chr16:57220925-57221005 1.0000 80 chr17:75449814-75449894 1.0000 80 chr6:119671601-119671681 1.0000 80 chr16:90234827-90234907 1.0000 80 chr9:135823447-135823527 1.0000 80 chr11:60621865-60621945 1.0000 80 chr1:114447409-114447489 1.0000 80 chr3:123751291-123751371 1.0000 80 chr1:147230969-147231049 1.0000 80 chr1:180123629-180123709 1.0000 80 chr6:137539933-137540013 1.0000 80 chrX:11776775-11776855 1.0000 80 chr9:68455444-68455524 1.0000 80 chr16:26867553-26867633 1.0000 80 chrX:47003675-47003755 1.0000 80 chr11:111742246-11174232 1.0000 80 chr2:87012802-87012882 1.0000 80 chr12:112431314-11243139 1.0000 80 chr3:49726949-49727029 1.0000 80 chr3:185277033-185277113 1.0000 80 chr2:174260679-174260759 1.0000 80 chr20:43160381-43160461 1.0000 80 chr20:16555666-16555746 1.0000 80 chr2:109336362-109336442 1.0000 80 chr5:71404819-71404899 1.0000 80 chr1:42921939-42922019 1.0000 80 chr6:32097836-32097916 1.0000 80 chr15:91593273-91593353 1.0000 80 chr17:31820462-31820542 1.0000 80 chr3:121468119-121468199 1.0000 80 chr16:58767808-58767888 1.0000 80 chr15:64995321-64995401 1.0000 80 chr14:50319577-50319657 1.0000 80 chr9:27573789-27573869 1.0000 80 chr8:86895222-86895302 1.0000 80 chr7:73116050-73116130 1.0000 80 chr21:44572848-44572928 1.0000 80 chr13:50194466-50194546 1.0000 80 chr8:68256264-68256344 1.0000 80 chr11:60929727-60929807 1.0000 80 chr8:133687839-133687919 1.0000 80 chr3:172428912-172428992 1.0000 80 chr5:137475083-137475163 1.0000 80 chr1:161499538-161499618 1.0000 80 chr18:72265062-72265142 1.0000 80 chr10:81838852-81838932 1.0000 80 chr17:30469308-30469388 1.0000 80 chr5:171605349-171605429 1.0000 80 chr6:139644897-139644977 1.0000 80 chr8:64058376-64058456 1.0000 80 chr16:84151171-84151251 1.0000 80 chr19:40779772-40779852 1.0000 80 chr2:200324388-200324468 1.0000 80 chr22:38668655-38668735 1.0000 80 chr8:38458658-38458738 1.0000 80 chr10:102289642-10228972 1.0000 80 chr19:5734110-5734190 1.0000 80 chr18:44498039-44498119 1.0000 80 chr17:73187880-73187960 1.0000 80 chr20:271432-271512 1.0000 80 chr15:78555872-78555952 1.0000 80 chr1:109060310-109060390 1.0000 80 chr2:75873811-75873891 1.0000 80 chr14:102785946-10278602 1.0000 80 chr8:100905939-100906019 1.0000 80 chr11:57001235-57001315 1.0000 80 chr8:59397269-59397349 1.0000 80 chr10:127585053-12758513 1.0000 80 chr2:181826115-181826195 1.0000 80 chr20:44614398-44614478 1.0000 80 chr3:140629781-140629861 1.0000 80 chr1:110198696-110198776 1.0000 80 chr2:62081298-62081378 1.0000 80 chr16:53468266-53468346 1.0000 80 chr17:2207050-2207130 1.0000 80 chr1:43990662-43990742 1.0000 80 chr1:166136136-166136216 1.0000 80 chr2:113239255-113239335 1.0000 80 chr4:185187229-185187309 1.0000 80 chr17:37037881-37037961 1.0000 80 chr15:101142324-10114240 1.0000 80 chr2:42775056-42775136 1.0000 80 chr20:42939766-42939846 1.0000 80 chr6:28778740-28778820 1.0000 80 chr13:79233304-79233384 1.0000 80 chr7:89874398-89874478 1.0000 80 chr5:130969666-130969746 1.0000 80 chr1:117169680-117169760 1.0000 80 chr13:26760718-26760798 1.0000 80 chrX:150151577-150151657 1.0000 80 chr22:31885803-31885883 1.0000 80 chr4:113558646-113558726 1.0000 80 chr13:41635589-41635669 1.0000 80 chr15:25123493-25123573 1.0000 80 chr13:28024652-28024732 1.0000 80 chr19:17355229-17355309 1.0000 80 chr2:45805767-45805847 1.0000 80 chr11:77530959-77531039 1.0000 80 chr15:34806592-34806672 1.0000 80 chr19:52430627-52430707 1.0000 80 chr7:129592146-129592226 1.0000 80 chr1:154833106-154833186 1.0000 80 chr20:33296975-33297055 1.0000 80 chr11:62779892-62779972 1.0000 80 chr8:74658930-74659010 1.0000 80 chr12:122690046-12269012 1.0000 80 chr15:25018318-25018398 1.0000 80 chr10:77268897-77268977 1.0000 80 chr4:185158902-185158982 1.0000 80 chr13:108870609-10887068 1.0000 80 chr19:200361-200441 1.0000 80 chr1:118251348-118251428 1.0000 80 chr15:78832981-78833061 1.0000 80 chrX:119737680-119737760 1.0000 80 chr4:147096770-147096850 1.0000 80 chr2:65547672-65547752 1.0000 80 chr3:24415125-24415205 1.0000 80 chr10:104192469-10419254 1.0000 80 chr3:191047100-191047180 1.0000 80 chr20:25388239-25388319 1.0000 80 chr20:35807991-35808071 1.0000 80 chr18:10525928-10526008 1.0000 80 chr1:151300233-151300313 1.0000 80 chrX:84258860-84258940 1.0000 80 chr13:103046935-10304701 1.0000 80 chrX:23925893-23925973 1.0000 80 chr16:67450402-67450482 1.0000 80 chr15:101792139-10179221 1.0000 80 chr5:115420633-115420713 1.0000 80 chr20:29611717-29611797 1.0000 80 chr6:38607343-38607423 1.0000 80 chr21:34494351-34494431 1.0000 80 chr5:180258673-180258753 1.0000 80 chrX:38186822-38186902 1.0000 80 chr1:161147084-161147164 1.0000 80 chr1:18993985-18994065 1.0000 80 chr14:55337571-55337651 1.0000 80 chr2:202645774-202645854 1.0000 80 chr4:123523983-123524063 1.0000 80 chr14:54955760-54955840 1.0000 80 chr19:49658484-49658564 1.0000 80 chr12:21590482-21590562 1.0000 80 chr13:45694536-45694616 1.0000 80 chr12:110338033-11033811 1.0000 80 chr2:207024141-207024221 1.0000 80 chr1:116961208-116961288 1.0000 80 chr6:150067718-150067798 1.0000 80 chr2:15701437-15701517 1.0000 80 chr11:71814088-71814168 1.0000 80 chr14:57735687-57735767 1.0000 80 chr9:5833098-5833178 1.0000 80 chr7:37745815-37745895 1.0000 80 chr19:44037264-44037344 1.0000 80 chr1:174972200-174972280 1.0000 80 chr18:43547312-43547392 1.0000 80 chr15:75743756-75743836 1.0000 80 chr15:50672392-50672472 1.0000 80 chr11:18610232-18610312 1.0000 80 chr2:242089009-242089089 1.0000 80 chr2:232826333-232826413 1.0000 80 chr19:49128371-49128451 1.0000 80 chr22:48027353-48027433 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_ZNF407/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/ZNF407.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.206 C 0.296 G 0.286 T 0.212 Background letter frequencies (from file dataset with add-one prior applied): A 0.206 C 0.296 G 0.286 T 0.212 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF GCYTCCGT MEME-1 width = 8 sites = 41 llr = 345 E-value = 6.6e-009 ******************************************************************************** -------------------------------------------------------------------------------- Motif GCYTCCGT MEME-1 Description -------------------------------------------------------------------------------- Simplified A :::2::1: pos.-specific C :a6:aa:: probability G a::1::9: matrix T ::46:::a bits 2.3 * 2.0 * 1.8 * ** * 1.6 ** ** * Relative 1.4 ** ** * Entropy 1.1 ** **** (12.1 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel GCCTCCGT consensus TA sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTCCGT MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr11:71814088-71814168 24 2.82e-05 TCCCCTCCAG GCCTCCGT ATTCAGTGAG chr14:55337571-55337651 44 2.82e-05 agccctgcct gcctccgt agactccacc chr19:17355229-17355309 13 2.82e-05 TCCGTCTGCC GCCTCCGT AGCCACAGCG chrX:150151577-150151657 27 2.82e-05 TCCCTGTTTG GCCTCCGT AGCCGGCGCC chr7:73116050-73116130 31 2.82e-05 CCTCCTGACG GCCTCCGT ACTTCCTAAC chr4:1723684-1723764 63 2.82e-05 GTCCCTTCCG GCCTCCGT CCTGGGGCCA chr13:42529807-42529887 37 2.82e-05 gtctaaggat gcctccgt acttggagtc chr1:14128463-14128543 26 2.82e-05 ACACCTGCAG GCCTCCGT AGGCTCCTCG chr11:8350532-8350612 45 2.82e-05 GCCTCTCCGG GCCTCCGT TTTTACACTT chr5:130969666-130969746 36 4.84e-05 ACCTATCATG GCTTCCGT TGTGACCTGA chr4:185187229-185187309 47 4.84e-05 gggaaataga gcttccgt aggcaactgt chr6:139644897-139644977 35 4.84e-05 TTACCTCCGG GCTTCCGT TGGCATCAGC chr1:114447409-114447489 67 4.84e-05 CTCAGGCTCG GCTTCCGT AGGGCC chr6:2766665-2766745 37 4.84e-05 TGGCCGTTGG GCTTCCGT AGTTATCTCG chr15:30917909-30917989 44 4.84e-05 TCTCAACTGG GCTTCCGT AGAACGGTTT chr1:22546132-22546212 67 4.84e-05 acccttctga gcttccgt tatgcc chr9:138904147-138904227 17 4.84e-05 ATCTCTCCGG GCTTCCGT AGCCCCAACG chr19:39042195-39042275 45 4.84e-05 gggcttgccg gcttccgt ccctgtcagg chr17:30668236-30668316 31 4.84e-05 TGCCACTTGG GCTTCCGT CCTCACTGTC chr15:32907272-32907352 65 4.84e-05 TCTCATCTGG GCTTCCGT AAGAACGG chr2:232826333-232826413 45 7.59e-05 GCCTCGCCCG GCCACCGT CGCTCTCTAG chr19:44037264-44037344 29 7.59e-05 ACTCCAGTCA GCCACCGT AGGCCCCGCC chr21:34494351-34494431 29 7.59e-05 gccctcatgg gccaccgt accctgcacc chr10:77268897-77268977 35 7.59e-05 GCCCTCATGG GCCACCGT TGCTGGCTGA chr15:101142324-10114240 68 7.59e-05 CCCGCTCTGG GCCACCGT AGTTC chr17:75449814-75449894 32 7.59e-05 AGCCTCCTGG GCCACCGT ATTCTCCCAA chr2:111489941-111490021 62 7.59e-05 GCAAGGGGAG GCCACCGT AGAAGCGCCC chr7:31174315-31174395 38 7.59e-05 GCTTCTCTCG GCCACCGT CATTCTCTCT chr7:129592146-129592226 54 1.54e-04 GTGCCAAGGA GCCGCCGT AGGCACTGGG chr19:52430627-52430707 65 1.54e-04 ACCTTCCTCG GCCGCCGT AGGCCGGC chr22:31885803-31885883 14 1.54e-04 TCTCTCTTCA GCCGCCGT AACTGCAGCC chr13:26760718-26760798 38 1.54e-04 GGCCTCCTCG GCCGCCGT CGTCTTCTCA chr5:132528467-132528547 35 1.54e-04 ggccttaccg gcctccat agtcacatga chr4:147096770-147096850 53 1.96e-04 GCCCCAGCGG GCTGCCGT AGCAGAGAAG chr17:31820462-31820542 38 1.96e-04 ACCCTCTGTA GCTTCCAT AGCTTTTCCT chr1:17093231-17093311 14 1.96e-04 gtcggacaac gctgCCGT AGATTGTCCC chr15:64995321-64995401 58 2.17e-04 CGGGCCGAGC GCCTCCTT TTGCCTCAGC chr6:160351040-160351120 53 2.36e-04 AATCCTCTCG GCCACCAT CCCCGTTCTG chrX:118320937-118321017 36 2.36e-04 AGCCTCGAGG GCCACCAT CCTCCCCAAA chr17:37037881-37037961 12 2.51e-04 CACAGGCCTG GCTTCCTT CTCTGAAGCA chr2:113239255-113239335 59 2.86e-04 GACGCTCCGG GTCTCCGT AGTCGTTAAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTCCGT MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr11:71814088-71814168 2.8e-05 23_[+1]_49 chr14:55337571-55337651 2.8e-05 43_[+1]_29 chr19:17355229-17355309 2.8e-05 12_[+1]_60 chrX:150151577-150151657 2.8e-05 26_[+1]_46 chr7:73116050-73116130 2.8e-05 30_[+1]_42 chr4:1723684-1723764 2.8e-05 62_[+1]_10 chr13:42529807-42529887 2.8e-05 36_[+1]_36 chr1:14128463-14128543 2.8e-05 25_[+1]_47 chr11:8350532-8350612 2.8e-05 44_[+1]_28 chr5:130969666-130969746 4.8e-05 35_[+1]_37 chr4:185187229-185187309 4.8e-05 46_[+1]_26 chr6:139644897-139644977 4.8e-05 34_[+1]_38 chr1:114447409-114447489 4.8e-05 66_[+1]_6 chr6:2766665-2766745 4.8e-05 36_[+1]_36 chr15:30917909-30917989 4.8e-05 43_[+1]_29 chr1:22546132-22546212 4.8e-05 66_[+1]_6 chr9:138904147-138904227 4.8e-05 16_[+1]_56 chr19:39042195-39042275 4.8e-05 44_[+1]_28 chr17:30668236-30668316 4.8e-05 30_[+1]_42 chr15:32907272-32907352 4.8e-05 64_[+1]_8 chr2:232826333-232826413 7.6e-05 44_[+1]_28 chr19:44037264-44037344 7.6e-05 28_[+1]_44 chr21:34494351-34494431 7.6e-05 28_[+1]_44 chr10:77268897-77268977 7.6e-05 34_[+1]_38 chr15:101142324-10114240 7.6e-05 67_[+1]_5 chr17:75449814-75449894 7.6e-05 31_[+1]_41 chr2:111489941-111490021 7.6e-05 61_[+1]_11 chr7:31174315-31174395 7.6e-05 37_[+1]_35 chr7:129592146-129592226 0.00015 53_[+1]_19 chr19:52430627-52430707 0.00015 64_[+1]_8 chr22:31885803-31885883 0.00015 13_[+1]_59 chr13:26760718-26760798 0.00015 37_[+1]_35 chr5:132528467-132528547 0.00015 34_[+1]_38 chr4:147096770-147096850 0.0002 52_[+1]_20 chr17:31820462-31820542 0.0002 37_[+1]_35 chr1:17093231-17093311 0.0002 13_[+1]_59 chr15:64995321-64995401 0.00022 57_[+1]_15 chr6:160351040-160351120 0.00024 52_[+1]_20 chrX:118320937-118321017 0.00024 35_[+1]_37 chr17:37037881-37037961 0.00025 11_[+1]_61 chr2:113239255-113239335 0.00029 58_[+1]_14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTCCGT MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GCYTCCGT width=8 seqs=41 chr11:71814088-71814168 ( 24) GCCTCCGT 1 chr14:55337571-55337651 ( 44) GCCTCCGT 1 chr19:17355229-17355309 ( 13) GCCTCCGT 1 chrX:150151577-150151657 ( 27) GCCTCCGT 1 chr7:73116050-73116130 ( 31) GCCTCCGT 1 chr4:1723684-1723764 ( 63) GCCTCCGT 1 chr13:42529807-42529887 ( 37) GCCTCCGT 1 chr1:14128463-14128543 ( 26) GCCTCCGT 1 chr11:8350532-8350612 ( 45) GCCTCCGT 1 chr5:130969666-130969746 ( 36) GCTTCCGT 1 chr4:185187229-185187309 ( 47) GCTTCCGT 1 chr6:139644897-139644977 ( 35) GCTTCCGT 1 chr1:114447409-114447489 ( 67) GCTTCCGT 1 chr6:2766665-2766745 ( 37) GCTTCCGT 1 chr15:30917909-30917989 ( 44) GCTTCCGT 1 chr1:22546132-22546212 ( 67) GCTTCCGT 1 chr9:138904147-138904227 ( 17) GCTTCCGT 1 chr19:39042195-39042275 ( 45) GCTTCCGT 1 chr17:30668236-30668316 ( 31) GCTTCCGT 1 chr15:32907272-32907352 ( 65) GCTTCCGT 1 chr2:232826333-232826413 ( 45) GCCACCGT 1 chr19:44037264-44037344 ( 29) GCCACCGT 1 chr21:34494351-34494431 ( 29) GCCACCGT 1 chr10:77268897-77268977 ( 35) GCCACCGT 1 chr15:101142324-10114240 ( 68) GCCACCGT 1 chr17:75449814-75449894 ( 32) GCCACCGT 1 chr2:111489941-111490021 ( 62) GCCACCGT 1 chr7:31174315-31174395 ( 38) GCCACCGT 1 chr7:129592146-129592226 ( 54) GCCGCCGT 1 chr19:52430627-52430707 ( 65) GCCGCCGT 1 chr22:31885803-31885883 ( 14) GCCGCCGT 1 chr13:26760718-26760798 ( 38) GCCGCCGT 1 chr5:132528467-132528547 ( 35) GCCTCCAT 1 chr4:147096770-147096850 ( 53) GCTGCCGT 1 chr17:31820462-31820542 ( 38) GCTTCCAT 1 chr1:17093231-17093311 ( 14) GCTGCCGT 1 chr15:64995321-64995401 ( 58) GCCTCCTT 1 chr6:160351040-160351120 ( 53) GCCACCAT 1 chrX:118320937-118321017 ( 36) GCCACCAT 1 chr17:37037881-37037961 ( 12) GCTTCCTT 1 chr2:113239255-113239335 ( 59) GTCTCCGT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTCCGT MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.25851 E= 6.6e-009 -1200 -1200 181 -1200 -1200 172 -1200 -312 -1200 110 -1200 79 24 -1200 -97 152 -1200 176 -1200 -1200 -1200 176 -1200 -1200 -108 -1200 158 -212 -1200 -1200 -1200 224 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTCCGT MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 41 E= 6.6e-009 0.000000 0.000000 1.000000 0.000000 0.000000 0.975610 0.000000 0.024390 0.000000 0.634146 0.000000 0.365854 0.243902 0.000000 0.146341 0.609756 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.097561 0.000000 0.853659 0.048780 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTCCGT MEME-1 regular expression -------------------------------------------------------------------------------- GC[CT][TA]CCGT -------------------------------------------------------------------------------- Time 4.99 secs. ******************************************************************************** ******************************************************************************** MOTIF ACGGHGGC MEME-2 width = 8 sites = 63 llr = 480 E-value = 5.0e-013 ******************************************************************************** -------------------------------------------------------------------------------- Motif ACGGHGGC MEME-2 Description -------------------------------------------------------------------------------- Simplified A a:::33:: pos.-specific C :8::3::a probability G ::aa178: matrix T :2::312: bits 2.3 * 2.0 * 1.8 * ** * 1.6 * ** * Relative 1.4 * ** * Entropy 1.1 **** ** (11.0 bits) 0.9 **** ** 0.7 **** *** 0.5 **** *** 0.2 ******** 0.0 -------- Multilevel ACGGAGGC consensus CA sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACGGHGGC MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:38186822-38186902 34 2.49e-05 GGGGAGGGGA ACGGAGGC CGGGTGGCTG chr1:161499538-161499618 16 2.49e-05 gaccgggaag acggaggc tgcagtgagc chr6:150067718-150067798 19 5.05e-05 TAGGACGGAG ACGGTGGC TGCAGAGAGT chr15:25018318-25018398 39 5.05e-05 GAGGGGGAAG ACGGTGGC CGGCAGCAGC chr17:73187880-73187960 29 5.05e-05 GGACTAGGAG ACGGTGGC TCATATgctc chr5:137475083-137475163 39 5.05e-05 CAGCGTGGGG ACGGTGGC TGCAGAGAGC chr2:47210481-47210561 33 5.05e-05 TTTCAGAGAA ACGGTGGC CTGGAGGGCT chr6:160351040-160351120 15 5.05e-05 GGCTCAGGTA ACGGTGGC AGCAGTTATA chr2:203776884-203776964 54 5.05e-05 GAAACGGTCG ACGGTGGC CGATAGTGGT chr19:37997944-37998024 46 5.05e-05 GCTGCCGACT ACGGTGGC CGACTGGGTC chr15:88558636-88558716 27 5.05e-05 TGCTACTGCT ACGGTGGC CTGGAAGGCC chr1:116961208-116961288 45 8.62e-05 TCTCTGCGCT ACGGCGGC TGCAGAGGGT chr13:103046935-10304701 12 8.62e-05 TTCCCGCGCT ACGGCGGC TCCAACGGGC chr11:57001235-57001315 3 8.62e-05 CC ACGGCGGC CTCAGAGGGA chr10:102289642-10228972 14 8.62e-05 AAGGCCTGTC ACGGCGGC TGAGCCGGGC chr2:200324388-200324468 46 8.62e-05 CGTTGACTGT ACGGCGGC GCCAGAGGGC chr8:133687839-133687919 25 8.62e-05 CGGGGACTCT ACGGCGGC CGCGCGGGAC chr16:90234827-90234907 2 8.62e-05 C ACGGCGGC CTCCCGGGGC chr17:9479170-9479250 7 8.62e-05 CTGACT ACGGCGGC CCGCGCGGCT chr16:449017-449097 31 8.62e-05 ATGGCGTGCA ACGGCGGC TCGTTGGGGA chr11:18610232-18610312 38 1.04e-04 TTGCTGCAGG ACGGAAGC CGCTGAGGAC chr16:57220925-57221005 14 1.04e-04 ATGTCCTACT ACGGAAGC CGGAGCTGAA chr18:44702668-44702748 66 1.04e-04 GCGCCTTCCT ACGGAAGC CGATGGG chr6:52020031-52020111 37 1.04e-04 tcatgtgact acggaagc tgacaagtcc chr19:44037264-44037344 71 1.23e-04 TTCTGTCGAT ACGGTAGC TT chr8:100905939-100906019 22 1.23e-04 GAACGCGGCG ACGGTAGC CGAAGGAGTT chr15:25123493-25123573 47 1.48e-04 GTTGGGGAGA ACGGCAGC CCGCAGGGGC chr8:59397269-59397349 5 1.48e-04 tgct acggcagc cctagtaggc chr5:71404819-71404899 8 1.48e-04 GGTCTCT ACGGCAGC CCGAGGCGGA chr2:219906260-219906340 24 1.48e-04 CAGGGCAACG ACGGCAGC CCGAGTAAGT chr8:9911641-9911721 4 1.48e-04 GAC ACGGCAGC AACTTTAAAA chr2:42775056-42775136 51 1.67e-04 ataaagaagt acggagtc cttctaaggc chr2:174260679-174260759 32 1.67e-04 atatagaagt acggagtc cttctcaggc chr16:26867553-26867633 38 1.67e-04 atatagaagt acggagtc cttctcaggc chr9:135823447-135823527 17 1.67e-04 atataaaagt acggagtc cttctcaggc chr19:40779772-40779852 34 2.04e-04 caaggcccct atggaggc tgccaggggc chr3:172428912-172428992 36 2.04e-04 TGCCCCCTCT ACGGTGTC CTTGCAAAGT chr11:111742246-11174232 34 2.04e-04 TGGCTGGCAA ACGGTGTC CGCCGAGGGA chr18:18691486-18691566 31 2.04e-04 GGCTGCTGCT ACGGTGTC CGGTGGGGCA chr2:128343589-128343669 17 2.04e-04 catctgcttg acggtgtc ctttgaggcc chrX:148713516-148713596 72 2.04e-04 TGGCAGGGGG ATGGAGGC T chr2:75873811-75873891 52 2.22e-04 CAGCCGCCAT ATGGTGGC AGACAGCAAC chr2:207479680-207479760 43 2.22e-04 AGCTCAGTGT ATGGTGGC CTAGGAGGGG chr2:191325468-191325548 29 2.22e-04 ACAGGTGGGG ATGGTGGC CGAGTGAGTC chr2:202645774-202645854 22 2.48e-04 GAGACTGTCG ACGGCGTC TGTTGGGGGT chr4:113558646-113558726 7 2.48e-04 CCTATG ACGGCGTC CTTGCGGAAG chr7:37745815-37745895 31 2.92e-04 cagggactct ACGGATGC ATAGAAGGGA chr2:207024141-207024221 7 2.92e-04 TTCAAT ATGGCGGC CTCGGCTAAC chrX:84258860-84258940 59 2.92e-04 GGTTGTAGAC ATGGCGGC CATCAGGGTA chr22:38668655-38668735 58 2.92e-04 GGGTGGGGAG ACGGATGC CCCCTCCCTC chr7:73116050-73116130 5 2.92e-04 CCAG ATGGCGGC AGCGGCAGCC chr3:185277033-185277113 8 2.92e-04 TTGGCGG ACGGATGC CGGGGCGGAC chr8:29172460-29172540 7 2.92e-04 TAGCGT ACGGATGC TGGGGTGGCA chr2:219151548-219151628 19 2.92e-04 CCTGCCAGAG ACGGATGC CCAGAGTGGA chr2:15701437-15701517 28 3.25e-04 GAGTGTCTCT ACGGAATC CCTCACAGGA chr20:44614398-44614478 3 3.51e-04 ga atggaagC TGAGCCTCAA chr12:112431314-11243139 13 3.51e-04 TAATTGCCCT ATGGAAGC TGCTAAGGTT chr20:3828168-3828248 57 3.51e-04 GATTCTCTGT ATGGAAGC CGTGAAGCCT chr15:34806592-34806672 34 3.99e-04 GGGCGCGGCG ACGGGGGC CTAGAGGGGC chr1:180123629-180123709 16 3.99e-04 TCCGTTGGAT ACGGGGGC CGTGAGAGGC chr9:86432914-86432994 5 3.99e-04 AGCT ACGGGGGC CGGGCAGGGT chr15:91593273-91593353 38 5.15e-04 TCTAAAAACT ACGGGAGC CACAGTGGAC chr15:30917909-30917989 55 5.75e-04 CTTCCGTAGA ACGGTTTC TTCGTAAGAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACGGHGGC MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:38186822-38186902 2.5e-05 33_[+2]_39 chr1:161499538-161499618 2.5e-05 15_[+2]_57 chr6:150067718-150067798 5e-05 18_[+2]_54 chr15:25018318-25018398 5e-05 38_[+2]_34 chr17:73187880-73187960 5e-05 28_[+2]_44 chr5:137475083-137475163 5e-05 38_[+2]_34 chr2:47210481-47210561 5e-05 32_[+2]_40 chr6:160351040-160351120 5e-05 14_[+2]_58 chr2:203776884-203776964 5e-05 53_[+2]_19 chr19:37997944-37998024 5e-05 45_[+2]_27 chr15:88558636-88558716 5e-05 26_[+2]_46 chr1:116961208-116961288 8.6e-05 44_[+2]_28 chr13:103046935-10304701 8.6e-05 11_[+2]_61 chr11:57001235-57001315 8.6e-05 2_[+2]_70 chr10:102289642-10228972 8.6e-05 13_[+2]_59 chr2:200324388-200324468 8.6e-05 45_[+2]_27 chr8:133687839-133687919 8.6e-05 24_[+2]_48 chr16:90234827-90234907 8.6e-05 1_[+2]_71 chr17:9479170-9479250 8.6e-05 6_[+2]_66 chr16:449017-449097 8.6e-05 30_[+2]_42 chr11:18610232-18610312 0.0001 37_[+2]_35 chr16:57220925-57221005 0.0001 13_[+2]_59 chr18:44702668-44702748 0.0001 65_[+2]_7 chr6:52020031-52020111 0.0001 36_[+2]_36 chr19:44037264-44037344 0.00012 70_[+2]_2 chr8:100905939-100906019 0.00012 21_[+2]_51 chr15:25123493-25123573 0.00015 46_[+2]_26 chr8:59397269-59397349 0.00015 4_[+2]_68 chr5:71404819-71404899 0.00015 7_[+2]_65 chr2:219906260-219906340 0.00015 23_[+2]_49 chr8:9911641-9911721 0.00015 3_[+2]_69 chr2:42775056-42775136 0.00017 50_[+2]_22 chr2:174260679-174260759 0.00017 31_[+2]_41 chr16:26867553-26867633 0.00017 37_[+2]_35 chr9:135823447-135823527 0.00017 16_[+2]_56 chr19:40779772-40779852 0.0002 33_[+2]_39 chr3:172428912-172428992 0.0002 35_[+2]_37 chr11:111742246-11174232 0.0002 33_[+2]_39 chr18:18691486-18691566 0.0002 30_[+2]_42 chr2:128343589-128343669 0.0002 16_[+2]_56 chrX:148713516-148713596 0.0002 71_[+2]_1 chr2:75873811-75873891 0.00022 51_[+2]_21 chr2:207479680-207479760 0.00022 42_[+2]_30 chr2:191325468-191325548 0.00022 28_[+2]_44 chr2:202645774-202645854 0.00025 21_[+2]_51 chr4:113558646-113558726 0.00025 6_[+2]_66 chr7:37745815-37745895 0.00029 30_[+2]_42 chr2:207024141-207024221 0.00029 6_[+2]_66 chrX:84258860-84258940 0.00029 58_[+2]_14 chr22:38668655-38668735 0.00029 57_[+2]_15 chr7:73116050-73116130 0.00029 4_[+2]_68 chr3:185277033-185277113 0.00029 7_[+2]_65 chr8:29172460-29172540 0.00029 6_[+2]_66 chr2:219151548-219151628 0.00029 18_[+2]_54 chr2:15701437-15701517 0.00032 27_[+2]_45 chr20:44614398-44614478 0.00035 2_[+2]_70 chr12:112431314-11243139 0.00035 12_[+2]_60 chr20:3828168-3828248 0.00035 56_[+2]_16 chr15:34806592-34806672 0.0004 33_[+2]_39 chr1:180123629-180123709 0.0004 15_[+2]_57 chr9:86432914-86432994 0.0004 4_[+2]_68 chr15:91593273-91593353 0.00051 37_[+2]_35 chr15:30917909-30917989 0.00057 54_[+2]_18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACGGHGGC MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ACGGHGGC width=8 seqs=63 chrX:38186822-38186902 ( 34) ACGGAGGC 1 chr1:161499538-161499618 ( 16) ACGGAGGC 1 chr6:150067718-150067798 ( 19) ACGGTGGC 1 chr15:25018318-25018398 ( 39) ACGGTGGC 1 chr17:73187880-73187960 ( 29) ACGGTGGC 1 chr5:137475083-137475163 ( 39) ACGGTGGC 1 chr2:47210481-47210561 ( 33) ACGGTGGC 1 chr6:160351040-160351120 ( 15) ACGGTGGC 1 chr2:203776884-203776964 ( 54) ACGGTGGC 1 chr19:37997944-37998024 ( 46) ACGGTGGC 1 chr15:88558636-88558716 ( 27) ACGGTGGC 1 chr1:116961208-116961288 ( 45) ACGGCGGC 1 chr13:103046935-10304701 ( 12) ACGGCGGC 1 chr11:57001235-57001315 ( 3) ACGGCGGC 1 chr10:102289642-10228972 ( 14) ACGGCGGC 1 chr2:200324388-200324468 ( 46) ACGGCGGC 1 chr8:133687839-133687919 ( 25) ACGGCGGC 1 chr16:90234827-90234907 ( 2) ACGGCGGC 1 chr17:9479170-9479250 ( 7) ACGGCGGC 1 chr16:449017-449097 ( 31) ACGGCGGC 1 chr11:18610232-18610312 ( 38) ACGGAAGC 1 chr16:57220925-57221005 ( 14) ACGGAAGC 1 chr18:44702668-44702748 ( 66) ACGGAAGC 1 chr6:52020031-52020111 ( 37) ACGGAAGC 1 chr19:44037264-44037344 ( 71) ACGGTAGC 1 chr8:100905939-100906019 ( 22) ACGGTAGC 1 chr15:25123493-25123573 ( 47) ACGGCAGC 1 chr8:59397269-59397349 ( 5) ACGGCAGC 1 chr5:71404819-71404899 ( 8) ACGGCAGC 1 chr2:219906260-219906340 ( 24) ACGGCAGC 1 chr8:9911641-9911721 ( 4) ACGGCAGC 1 chr2:42775056-42775136 ( 51) ACGGAGTC 1 chr2:174260679-174260759 ( 32) ACGGAGTC 1 chr16:26867553-26867633 ( 38) ACGGAGTC 1 chr9:135823447-135823527 ( 17) ACGGAGTC 1 chr19:40779772-40779852 ( 34) ATGGAGGC 1 chr3:172428912-172428992 ( 36) ACGGTGTC 1 chr11:111742246-11174232 ( 34) ACGGTGTC 1 chr18:18691486-18691566 ( 31) ACGGTGTC 1 chr2:128343589-128343669 ( 17) ACGGTGTC 1 chrX:148713516-148713596 ( 72) ATGGAGGC 1 chr2:75873811-75873891 ( 52) ATGGTGGC 1 chr2:207479680-207479760 ( 43) ATGGTGGC 1 chr2:191325468-191325548 ( 29) ATGGTGGC 1 chr2:202645774-202645854 ( 22) ACGGCGTC 1 chr4:113558646-113558726 ( 7) ACGGCGTC 1 chr7:37745815-37745895 ( 31) ACGGATGC 1 chr2:207024141-207024221 ( 7) ATGGCGGC 1 chrX:84258860-84258940 ( 59) ATGGCGGC 1 chr22:38668655-38668735 ( 58) ACGGATGC 1 chr7:73116050-73116130 ( 5) ATGGCGGC 1 chr3:185277033-185277113 ( 8) ACGGATGC 1 chr8:29172460-29172540 ( 7) ACGGATGC 1 chr2:219151548-219151628 ( 19) ACGGATGC 1 chr2:15701437-15701517 ( 28) ACGGAATC 1 chr20:44614398-44614478 ( 3) ATGGAAGC 1 chr12:112431314-11243139 ( 13) ATGGAAGC 1 chr20:3828168-3828248 ( 57) ATGGAAGC 1 chr15:34806592-34806672 ( 34) ACGGGGGC 1 chr1:180123629-180123709 ( 16) ACGGGGGC 1 chr9:86432914-86432994 ( 5) ACGGGGGC 1 chr15:91593273-91593353 ( 38) ACGGGAGC 1 chr15:30917909-30917989 ( 55) ACGGTTTC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACGGHGGC MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.89709 E= 5.0e-013 228 -1262 -1262 -1262 -1262 148 -1262 -28 -1262 -1262 181 -1262 -1262 -1262 181 -1262 69 3 -217 51 30 -1262 119 -116 -1262 -1262 150 -16 -1262 176 -1262 -1262 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACGGHGGC MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 63 E= 5.0e-013 1.000000 0.000000 0.000000 0.000000 0.000000 0.825397 0.000000 0.174603 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.333333 0.301587 0.063492 0.301587 0.253968 0.000000 0.650794 0.095238 0.000000 0.000000 0.809524 0.190476 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACGGHGGC MEME-2 regular expression -------------------------------------------------------------------------------- ACGG[ACT][GA]GC -------------------------------------------------------------------------------- Time 8.72 secs. ******************************************************************************** ******************************************************************************** MOTIF TTTGTCCC MEME-3 width = 8 sites = 54 llr = 402 E-value = 1.3e+000 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTTGTCCC MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::::1::1 pos.-specific C :::1:687 probability G :::931:: matrix T aaa:6322 bits 2.3 2.0 *** 1.8 *** 1.6 *** Relative 1.4 **** Entropy 1.1 **** * (10.7 bits) 0.9 **** * 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTTGTCCC consensus GTTT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTGTCCC MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:84258860-84258940 7 1.50e-05 AACTGA TTTGTCCC TCTCTGCTCT chr2:75873811-75873891 30 1.50e-05 ACTTATCCAT TTTGTCCC ATAGCAGCCG chr18:18691486-18691566 2 1.50e-05 T TTTGTCCC GTCGCTGCTG chr1:145516240-145516320 63 1.50e-05 TCTGATACTG TTTGTCCC TCGCGAGGCA chr12:4714032-4714112 11 1.50e-05 GGGTAAGAAG TTTGTCCC ACGAGGTTTC chr13:43597680-43597760 20 1.50e-05 CGCTAACTAG TTTGTCCC TACGGCCGCC chr15:50672392-50672472 63 2.57e-05 aggatttgga tttgttcc aactccttgc chr3:72846955-72847035 17 2.57e-05 CTTGATCTCT TTTGTTCC GACTATGTCA chr22:48027353-48027433 28 3.64e-05 cctccacctt tttgtcct gttccggctt chr11:60929727-60929807 44 3.64e-05 gtatcttaag tttgtcct aaaggtttct chr10:29421364-29421444 55 3.64e-05 GCTGAGAAAG TTTGTCCT TCCTGCCACC chr11:34805739-34805819 55 3.64e-05 CTTGCACTTG TTTGTCCT GTTTGGGCTC chr2:211342321-211342401 24 3.64e-05 TTGGCCTAAG TTTGTCCT TCTGAGGCTG chr16:53468266-53468346 3 6.74e-05 TT TTTGGCCC CCTTGAACCG chr8:38458658-38458738 17 6.74e-05 CCGCTCGCGA TTTGGCCC CTCGGGGCCC chr3:49726949-49727029 15 6.74e-05 GTGCGCGTGA TTTGGCCC TGAACGGACG chr1:147230969-147231049 33 6.74e-05 CCCGGACCTC TTTGGCCC TCTCGGCCTC chr2:15701437-15701517 70 8.28e-05 CGCGGCCGCT TTTGTTTC ACG chr2:87012802-87012882 64 8.28e-05 TTTACCTAGT TTTGTTTC CCGTCAAAC chr11:62779892-62779972 30 1.12e-04 TGTCTTTGCG TTTGACCC TTCTCCCCCA chr19:17355229-17355309 46 1.12e-04 GGAAGTGATA TTTGACCC CAAGGGCGCG chr10:127585053-12758513 18 1.12e-04 TCCTGCGGCT TTTGGTCC CTCCCGCTCG chr17:31820462-31820542 24 1.12e-04 GTGGGTACTT TTTGACCC TCTGTAGCTT chr4:1723684-1723764 49 1.12e-04 CCTGTTGTTC TTTGGTCC CTTCCGGCCT chr2:176940285-176940365 42 1.12e-04 ACTTGGGCTT TTTGGTCC CAAACGCGCC chr1:22546132-22546212 53 1.12e-04 gggcaagtct tttgaccc ttctgagctt chr16:26867553-26867633 10 1.44e-04 agattacag tttgtcca caggactcaa chr5:132528467-132528547 22 1.44e-04 ccaggccgat tttggcct taccggcctc chr8:9911641-9911721 54 1.44e-04 CGGCGTGTTT TTTGGCCT CTGCAGCTTC chr1:154833106-154833186 25 1.59e-04 CGGGAAGCCA TTTGGCTC ATGAGAAAAG chr7:89874398-89874478 49 1.59e-04 TTTGGGGTGG TTTGGCTC TCCGGCTTTC chr14:57735687-57735767 30 1.69e-04 TATGAGGAAC TTTGATCC TTGCGGGCCA chr17:30668236-30668316 17 1.99e-04 AGTTTCTGCA TTTGTGCC ACTTGGGCTT chr16:84151171-84151251 37 2.05e-04 CTAGGATCAG TTTGTTTT CAATGTAAAT chr5:130969666-130969746 22 2.33e-04 AATAACATAA TTTGACCT ATCATGGCTT chr13:42529807-42529887 23 2.33e-04 ttcaaccaaa tttggtct aaggatgcct chr11:57001235-57001315 24 2.65e-04 AGAGGGACAA TTTCTTCC CTTCTAGAAG chr6:119671601-119671681 13 2.65e-04 GTATGCGCCC TTTCTTCC CCCAAAAAAC chr4:185158902-185158982 37 3.04e-04 TTCAGAGAAG TTTGGCCA CACTCACCTT chr1:185862014-185862094 46 3.04e-04 cgccttgcag tttgatct cagactgctg chr14:56643301-56643381 55 3.04e-04 gactctctgg tttggcca ctcttggata chr13:50194466-50194546 28 3.55e-04 GGTGCGTTGT TTTCTCTC CACTAAGGCT chr14:50319577-50319657 30 3.55e-04 GGCGAACGTA TTTGTGTC GCTTTTCTGA chr18:44702668-44702748 13 3.55e-04 GTCCAAGCGA TTTCTCTC CCGCCGCCGC chr15:31115774-31115854 11 3.55e-04 CAGGCCTGGC TTTGTGTC CTGACAGAGA chr11:8350532-8350612 5 3.55e-04 TTCA TTTGTGTC CCTGAATTGG chr2:47210481-47210561 18 4.15e-04 GTTGCTGAGC TTTGGTTT CAGAGAAACG chr1:117169680-117169760 29 4.52e-04 CTGACCGCTC TTTCTTTC CGTCCGGTTT chr11:71814088-71814168 10 5.37e-04 CCTCTGTAA TCTGTCCC CTCCAGGCCT chr20:43160381-43160461 24 5.37e-04 CGACTCCCAC TTCGTCCC TCCTCTGCCC chr19:14224999-14225079 46 5.37e-04 TGTTCGGCTG TCTGTCCC CAGAACCCTG chr17:9479170-9479250 37 5.37e-04 CTCCCCGCAG TTCGTCCC GTGCGCGACC chrX:23925893-23925973 18 6.40e-04 AGGGCCTTGA TTTCTCCA ACCGCAAGCA chr1:17093231-17093311 24 6.40e-04 gctgCCGTAG ATTGTCCC ACTCTGAAAT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTGTCCC MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:84258860-84258940 1.5e-05 6_[+3]_66 chr2:75873811-75873891 1.5e-05 29_[+3]_43 chr18:18691486-18691566 1.5e-05 1_[+3]_71 chr1:145516240-145516320 1.5e-05 62_[+3]_10 chr12:4714032-4714112 1.5e-05 10_[+3]_62 chr13:43597680-43597760 1.5e-05 19_[+3]_53 chr15:50672392-50672472 2.6e-05 62_[+3]_10 chr3:72846955-72847035 2.6e-05 16_[+3]_56 chr22:48027353-48027433 3.6e-05 27_[+3]_45 chr11:60929727-60929807 3.6e-05 43_[+3]_29 chr10:29421364-29421444 3.6e-05 54_[+3]_18 chr11:34805739-34805819 3.6e-05 54_[+3]_18 chr2:211342321-211342401 3.6e-05 23_[+3]_49 chr16:53468266-53468346 6.7e-05 2_[+3]_70 chr8:38458658-38458738 6.7e-05 16_[+3]_56 chr3:49726949-49727029 6.7e-05 14_[+3]_58 chr1:147230969-147231049 6.7e-05 32_[+3]_40 chr2:15701437-15701517 8.3e-05 69_[+3]_3 chr2:87012802-87012882 8.3e-05 63_[+3]_9 chr11:62779892-62779972 0.00011 29_[+3]_43 chr19:17355229-17355309 0.00011 45_[+3]_27 chr10:127585053-12758513 0.00011 17_[+3]_55 chr17:31820462-31820542 0.00011 23_[+3]_49 chr4:1723684-1723764 0.00011 48_[+3]_24 chr2:176940285-176940365 0.00011 41_[+3]_31 chr1:22546132-22546212 0.00011 52_[+3]_20 chr16:26867553-26867633 0.00014 9_[+3]_63 chr5:132528467-132528547 0.00014 21_[+3]_51 chr8:9911641-9911721 0.00014 53_[+3]_19 chr1:154833106-154833186 0.00016 24_[+3]_48 chr7:89874398-89874478 0.00016 48_[+3]_24 chr14:57735687-57735767 0.00017 29_[+3]_43 chr17:30668236-30668316 0.0002 16_[+3]_56 chr16:84151171-84151251 0.0002 36_[+3]_36 chr5:130969666-130969746 0.00023 21_[+3]_51 chr13:42529807-42529887 0.00023 22_[+3]_50 chr11:57001235-57001315 0.00026 23_[+3]_49 chr6:119671601-119671681 0.00026 12_[+3]_60 chr4:185158902-185158982 0.0003 36_[+3]_36 chr1:185862014-185862094 0.0003 45_[+3]_27 chr14:56643301-56643381 0.0003 54_[+3]_18 chr13:50194466-50194546 0.00035 27_[+3]_45 chr14:50319577-50319657 0.00035 29_[+3]_43 chr18:44702668-44702748 0.00035 12_[+3]_60 chr15:31115774-31115854 0.00035 10_[+3]_62 chr11:8350532-8350612 0.00035 4_[+3]_68 chr2:47210481-47210561 0.00042 17_[+3]_55 chr1:117169680-117169760 0.00045 28_[+3]_44 chr11:71814088-71814168 0.00054 9_[+3]_63 chr20:43160381-43160461 0.00054 23_[+3]_49 chr19:14224999-14225079 0.00054 45_[+3]_27 chr17:9479170-9479250 0.00054 36_[+3]_36 chrX:23925893-23925973 0.00064 17_[+3]_55 chr1:17093231-17093311 0.00064 23_[+3]_49 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTGTCCC MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTTGTCCC width=8 seqs=54 chrX:84258860-84258940 ( 7) TTTGTCCC 1 chr2:75873811-75873891 ( 30) TTTGTCCC 1 chr18:18691486-18691566 ( 2) TTTGTCCC 1 chr1:145516240-145516320 ( 63) TTTGTCCC 1 chr12:4714032-4714112 ( 11) TTTGTCCC 1 chr13:43597680-43597760 ( 20) TTTGTCCC 1 chr15:50672392-50672472 ( 63) TTTGTTCC 1 chr3:72846955-72847035 ( 17) TTTGTTCC 1 chr22:48027353-48027433 ( 28) TTTGTCCT 1 chr11:60929727-60929807 ( 44) TTTGTCCT 1 chr10:29421364-29421444 ( 55) TTTGTCCT 1 chr11:34805739-34805819 ( 55) TTTGTCCT 1 chr2:211342321-211342401 ( 24) TTTGTCCT 1 chr16:53468266-53468346 ( 3) TTTGGCCC 1 chr8:38458658-38458738 ( 17) TTTGGCCC 1 chr3:49726949-49727029 ( 15) TTTGGCCC 1 chr1:147230969-147231049 ( 33) TTTGGCCC 1 chr2:15701437-15701517 ( 70) TTTGTTTC 1 chr2:87012802-87012882 ( 64) TTTGTTTC 1 chr11:62779892-62779972 ( 30) TTTGACCC 1 chr19:17355229-17355309 ( 46) TTTGACCC 1 chr10:127585053-12758513 ( 18) TTTGGTCC 1 chr17:31820462-31820542 ( 24) TTTGACCC 1 chr4:1723684-1723764 ( 49) TTTGGTCC 1 chr2:176940285-176940365 ( 42) TTTGGTCC 1 chr1:22546132-22546212 ( 53) TTTGACCC 1 chr16:26867553-26867633 ( 10) TTTGTCCA 1 chr5:132528467-132528547 ( 22) TTTGGCCT 1 chr8:9911641-9911721 ( 54) TTTGGCCT 1 chr1:154833106-154833186 ( 25) TTTGGCTC 1 chr7:89874398-89874478 ( 49) TTTGGCTC 1 chr14:57735687-57735767 ( 30) TTTGATCC 1 chr17:30668236-30668316 ( 17) TTTGTGCC 1 chr16:84151171-84151251 ( 37) TTTGTTTT 1 chr5:130969666-130969746 ( 22) TTTGACCT 1 chr13:42529807-42529887 ( 23) TTTGGTCT 1 chr11:57001235-57001315 ( 24) TTTCTTCC 1 chr6:119671601-119671681 ( 13) TTTCTTCC 1 chr4:185158902-185158982 ( 37) TTTGGCCA 1 chr1:185862014-185862094 ( 46) TTTGATCT 1 chr14:56643301-56643381 ( 55) TTTGGCCA 1 chr13:50194466-50194546 ( 28) TTTCTCTC 1 chr14:50319577-50319657 ( 30) TTTGTGTC 1 chr18:44702668-44702748 ( 13) TTTCTCTC 1 chr15:31115774-31115854 ( 11) TTTGTGTC 1 chr11:8350532-8350612 ( 5) TTTGTGTC 1 chr2:47210481-47210561 ( 18) TTTGGTTT 1 chr1:117169680-117169760 ( 29) TTTCTTTC 1 chr11:71814088-71814168 ( 10) TCTGTCCC 1 chr20:43160381-43160461 ( 24) TTCGTCCC 1 chr19:14224999-14225079 ( 46) TCTGTCCC 1 chr17:9479170-9479250 ( 37) TTCGTCCC 1 chrX:23925893-23925973 ( 18) TTTCTCCA 1 chr1:17093231-17093311 ( 24) ATTGTCCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTGTCCC MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.96686 E= 1.3e+000 -348 -1240 -1240 221 -1240 -299 -1240 218 -1240 -299 -1240 218 -1240 -141 164 -1240 -67 -1240 -4 148 -1240 113 -195 39 -1240 140 -1240 7 -148 125 -1240 7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTGTCCC MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 54 E= 1.3e+000 0.018519 0.000000 0.000000 0.981481 0.000000 0.037037 0.000000 0.962963 0.000000 0.037037 0.000000 0.962963 0.000000 0.111111 0.888889 0.000000 0.129630 0.000000 0.277778 0.592593 0.000000 0.648148 0.074074 0.277778 0.000000 0.777778 0.000000 0.222222 0.074074 0.703704 0.000000 0.222222 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTGTCCC MEME-3 regular expression -------------------------------------------------------------------------------- TTTG[TG][CT][CT][CT] -------------------------------------------------------------------------------- Time 12.35 secs. ******************************************************************************** ******************************************************************************** MOTIF GGMCAAAM MEME-4 width = 8 sites = 35 llr = 296 E-value = 8.6e-005 ******************************************************************************** -------------------------------------------------------------------------------- Motif GGMCAAAM MEME-4 Description -------------------------------------------------------------------------------- Simplified A ::51aa84 pos.-specific C ::49:::4 probability G aa::::21 matrix T ::1::::1 bits 2.3 ** 2.0 ** 1.8 ** ** 1.6 ** ** Relative 1.4 ** **** Entropy 1.1 ** **** (12.2 bits) 0.9 ** **** 0.7 ******* 0.5 ******** 0.2 ******** 0.0 -------- Multilevel GGACAAAC consensus C GA sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGMCAAAM MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr12:122690046-12269012 25 8.98e-06 GACACCAGAG GGACAAAA ATGAGAAACT chr2:45805767-45805847 50 8.98e-06 ATCCacagaa ggacaaaa gaaactggag chr11:111742246-11174232 49 8.98e-06 GTCCGCCGAG GGACAAAA GACCTTGACA chr12:125354107-12535418 64 8.98e-06 gtgagagaaa ggacaaaa taaaaagca chr1:202523993-202524073 28 8.98e-06 AAGCCTATAG GGACAAAA ACTGGTATGG chr18:43547312-43547392 48 2.19e-05 CCGCAACGTA GGACAAAC CACTCCAGGA chr19:49658484-49658564 57 2.19e-05 GCGGCAATGT GGACAAAC GTTGGGGTCT chr20:16555666-16555746 26 2.19e-05 AGCTGCGTGG GGACAAAC TGTTCGGGCC chr12:118813277-11881335 61 2.19e-05 GGGCTACTTT GGACAAAC CATTAAAAAC chr13:50194466-50194546 55 3.48e-05 TGCTGGGTGG GGCCAAAA TAGTCCAGGC chr11:60621865-60621945 35 3.48e-05 GGCCCAGTGG GGCCAAAA GATCTCTCCC chr9:5833098-5833178 44 5.33e-05 AACTGCAGAG GGCCAAAC TTCTTCTGAT chr16:67450402-67450482 24 5.33e-05 GCCCCACAGC GGCCAAAC CGCGCTGCGT chr10:102289642-10228972 29 5.33e-05 GGCTGAGCCG GGCCAAAC GTGACGGAGG chr2:200324388-200324468 61 5.33e-05 GGCGCCAGAG GGCCAAAC TAAGTTCGGT chr1:180123629-180123709 31 5.33e-05 GGCCGTGAGA GGCCAAAC AACCTCCGCG chr14:59113325-59113405 14 5.33e-05 AGGCGGTGGT GGCCAAAC CTAAGCACAA chr1:18993985-18994065 55 6.26e-05 AGCGCCAGGA GGACAAAT CACAGAAGGT chr11:77530959-77531039 45 6.26e-05 AAGGGAAAAG GGACAAAT CTCTCAGGGG chr16:53536953-53537033 14 6.26e-05 CTAGAAAGAT GGACAAAT GCCGGGCCCG chr1:174972200-174972280 30 7.51e-05 TCGAGAGTGT GGACAAGA GGGTTGGGCA chr7:37745815-37745895 46 7.51e-05 TGCATAGAAG GGACAAGA TGGTGCAAGT chr3:123751291-123751371 24 7.51e-05 GACAAACGAG GGACAAGA GAGTGACGGA chr2:202645774-202645854 37 8.43e-05 GTCTGTTGGG GGTCAAAA TTGCTGAGAA chr5:71404819-71404899 23 9.68e-05 AGCCCGAGGC GGACAAAG GGCGTTCACG chr2:15701437-15701517 43 1.15e-04 ATCCCTCACA GGACAAGC TTCTCTATCC chr1:42921939-42922019 10 1.28e-04 GCCGGTAAG GGTCAAAC ATGGCCAGTT chr19:37997944-37998024 5 1.28e-04 AAAC GGTCAAAC CTGGGACTAG chr13:108870609-10887068 16 1.59e-04 GAGGGTGGAA GGCCAAGA TCCCTAGGTC chr2:219151548-219151628 34 1.65e-04 TGCCCAGAGT GGAAAAAA ATAGCTCAGA chr8:64058376-64058456 26 1.83e-04 tgggggcatg ggccaaag atggcacctg chr6:32097836-32097916 42 1.83e-04 GTACCTGCGC GGCCAAAG TGCCTAGCAT chr17:37037881-37037961 47 2.09e-04 CTCCATGCTG GGCCAAGC CCAGTGCAGG chr1:145516240-145516320 38 2.09e-04 CCGCTTCCAG GGCCAAGC TTTCTTTTCT chr15:50672392-50672472 14 2.27e-04 ccatcaaaat ggcaaaaa tgaaaacgac -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGMCAAAM MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:122690046-12269012 9e-06 24_[+4]_48 chr2:45805767-45805847 9e-06 49_[+4]_23 chr11:111742246-11174232 9e-06 48_[+4]_24 chr12:125354107-12535418 9e-06 63_[+4]_9 chr1:202523993-202524073 9e-06 27_[+4]_45 chr18:43547312-43547392 2.2e-05 47_[+4]_25 chr19:49658484-49658564 2.2e-05 56_[+4]_16 chr20:16555666-16555746 2.2e-05 25_[+4]_47 chr12:118813277-11881335 2.2e-05 60_[+4]_12 chr13:50194466-50194546 3.5e-05 54_[+4]_18 chr11:60621865-60621945 3.5e-05 34_[+4]_38 chr9:5833098-5833178 5.3e-05 43_[+4]_29 chr16:67450402-67450482 5.3e-05 23_[+4]_49 chr10:102289642-10228972 5.3e-05 28_[+4]_44 chr2:200324388-200324468 5.3e-05 60_[+4]_12 chr1:180123629-180123709 5.3e-05 30_[+4]_42 chr14:59113325-59113405 5.3e-05 13_[+4]_59 chr1:18993985-18994065 6.3e-05 54_[+4]_18 chr11:77530959-77531039 6.3e-05 44_[+4]_28 chr16:53536953-53537033 6.3e-05 13_[+4]_59 chr1:174972200-174972280 7.5e-05 29_[+4]_43 chr7:37745815-37745895 7.5e-05 45_[+4]_27 chr3:123751291-123751371 7.5e-05 23_[+4]_49 chr2:202645774-202645854 8.4e-05 36_[+4]_36 chr5:71404819-71404899 9.7e-05 22_[+4]_50 chr2:15701437-15701517 0.00011 42_[+4]_30 chr1:42921939-42922019 0.00013 9_[+4]_63 chr19:37997944-37998024 0.00013 4_[+4]_68 chr13:108870609-10887068 0.00016 15_[+4]_57 chr2:219151548-219151628 0.00017 33_[+4]_39 chr8:64058376-64058456 0.00018 25_[+4]_47 chr6:32097836-32097916 0.00018 41_[+4]_31 chr17:37037881-37037961 0.00021 46_[+4]_26 chr1:145516240-145516320 0.00021 37_[+4]_35 chr15:50672392-50672472 0.00023 13_[+4]_59 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGMCAAAM MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GGMCAAAM width=8 seqs=35 chr12:122690046-12269012 ( 25) GGACAAAA 1 chr2:45805767-45805847 ( 50) GGACAAAA 1 chr11:111742246-11174232 ( 49) GGACAAAA 1 chr12:125354107-12535418 ( 64) GGACAAAA 1 chr1:202523993-202524073 ( 28) GGACAAAA 1 chr18:43547312-43547392 ( 48) GGACAAAC 1 chr19:49658484-49658564 ( 57) GGACAAAC 1 chr20:16555666-16555746 ( 26) GGACAAAC 1 chr12:118813277-11881335 ( 61) GGACAAAC 1 chr13:50194466-50194546 ( 55) GGCCAAAA 1 chr11:60621865-60621945 ( 35) GGCCAAAA 1 chr9:5833098-5833178 ( 44) GGCCAAAC 1 chr16:67450402-67450482 ( 24) GGCCAAAC 1 chr10:102289642-10228972 ( 29) GGCCAAAC 1 chr2:200324388-200324468 ( 61) GGCCAAAC 1 chr1:180123629-180123709 ( 31) GGCCAAAC 1 chr14:59113325-59113405 ( 14) GGCCAAAC 1 chr1:18993985-18994065 ( 55) GGACAAAT 1 chr11:77530959-77531039 ( 45) GGACAAAT 1 chr16:53536953-53537033 ( 14) GGACAAAT 1 chr1:174972200-174972280 ( 30) GGACAAGA 1 chr7:37745815-37745895 ( 46) GGACAAGA 1 chr3:123751291-123751371 ( 24) GGACAAGA 1 chr2:202645774-202645854 ( 37) GGTCAAAA 1 chr5:71404819-71404899 ( 23) GGACAAAG 1 chr2:15701437-15701517 ( 43) GGACAAGC 1 chr1:42921939-42922019 ( 10) GGTCAAAC 1 chr19:37997944-37998024 ( 5) GGTCAAAC 1 chr13:108870609-10887068 ( 16) GGCCAAGA 1 chr2:219151548-219151628 ( 34) GGAAAAAA 1 chr8:64058376-64058456 ( 26) GGCCAAAG 1 chr6:32097836-32097916 ( 42) GGCCAAAG 1 chr17:37037881-37037961 ( 47) GGCCAAGC 1 chr1:145516240-145516320 ( 38) GGCCAAGC 1 chr15:50672392-50672472 ( 14) GGCAAAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGMCAAAM MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.84661 E= 8.6e-005 -1177 -1177 181 -1177 -1177 -1177 181 -1177 132 44 -1177 -131 -185 167 -1177 -1177 228 -1177 -1177 -1177 228 -1177 -1177 -1177 195 -1177 -51 -1177 95 54 -174 -131 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGMCAAAM MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 35 E= 8.6e-005 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.514286 0.400000 0.000000 0.085714 0.057143 0.942857 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.800000 0.000000 0.200000 0.000000 0.400000 0.428571 0.085714 0.085714 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGMCAAAM MEME-4 regular expression -------------------------------------------------------------------------------- GG[AC]CAA[AG][CA] -------------------------------------------------------------------------------- Time 15.87 secs. ******************************************************************************** ******************************************************************************** MOTIF ARRSAARA MEME-5 width = 8 sites = 21 llr = 185 E-value = 5.7e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif ARRSAARA MEME-5 Description -------------------------------------------------------------------------------- Simplified A a64:aa5a pos.-specific C :::3:::: probability G :457::5: matrix T ::1::::: bits 2.3 * ** * 2.0 * ** * 1.8 * ** * 1.6 * ** * Relative 1.4 * ** * Entropy 1.1 ** **** (12.7 bits) 0.9 ** ***** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AAGGAAAA consensus GAC G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRSAARA MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr17:73187880-73187960 4 4.50e-06 gga aaagaaaa agaaAGTGGA chr2:203776884-203776964 21 4.50e-06 GCGGAAATAC AAAGAAAA GAACGGATGA chr12:125354107-12535418 13 1.08e-05 TGCTGaggga aaggaaaa agaggaagaa chr10:30638343-30638423 32 1.70e-05 TTGAGGCCGG AAAGAAGA TACCTAAGCT chr8:64058376-64058456 64 2.57e-05 ggcaggagag aaggaaga acctgaaag chr15:91593273-91593353 16 2.57e-05 CAAGATCACC AAGGAAGA CAAGTCTAAA chr13:79233304-79233384 69 3.19e-05 CCCGCCCAGG AGAGAAAA CGAA chr11:77530959-77531039 36 4.53e-05 CTCGAGGGGA AGGGAAAA GGGACAAATC chr2:113239255-113239335 39 4.53e-05 CACTCGACAC AAACAAAA CCGACGCTCC chr6:119671601-119671681 27 4.53e-05 TTCCCCCAAA AAACAAAA AACCGAAAAA chr19:5734110-5734190 7 5.64e-05 AACCAA AATGAAAA TTGGCCTGAG chr4:147096770-147096850 64 6.51e-05 CTGCCGTAGC AGAGAAGA GCACTGATT chr18:72265062-72265142 46 8.36e-05 TTCCTCCCAA AGGGAAGA CGGTGAGCCG chr9:86432914-86432994 68 8.36e-05 TCGGGGTCAC AGGGAAGA GAAGG chr2:65547672-65547752 13 9.26e-05 TTCTACAGTG AAGCAAGA AGGCCAGAAG chr22:42394790-42394870 26 9.26e-05 AGGAGGCCCG AAGCAAGA TGGCGGTGAA chr8:71504842-71504922 41 1.05e-04 TACCATAGTC AATGAAGA AGATATAGAC chr20:271432-271512 27 1.14e-04 TAACCTCTCA AGGCAAAA TCTAGTTCGG chrX:47003675-47003755 47 1.14e-04 AACACAAGGT AGGCAAAA TTCCCAAGTC chr1:114447409-114447489 29 1.21e-04 AATATGAGTC AGTGAAAA TACAAAAGGC chr7:67981985-67982065 66 1.35e-04 cttaataggt agacaaga ttgaaaa -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRSAARA MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr17:73187880-73187960 4.5e-06 3_[+5]_69 chr2:203776884-203776964 4.5e-06 20_[+5]_52 chr12:125354107-12535418 1.1e-05 12_[+5]_60 chr10:30638343-30638423 1.7e-05 31_[+5]_41 chr8:64058376-64058456 2.6e-05 63_[+5]_9 chr15:91593273-91593353 2.6e-05 15_[+5]_57 chr13:79233304-79233384 3.2e-05 68_[+5]_4 chr11:77530959-77531039 4.5e-05 35_[+5]_37 chr2:113239255-113239335 4.5e-05 38_[+5]_34 chr6:119671601-119671681 4.5e-05 26_[+5]_46 chr19:5734110-5734190 5.6e-05 6_[+5]_66 chr4:147096770-147096850 6.5e-05 63_[+5]_9 chr18:72265062-72265142 8.4e-05 45_[+5]_27 chr9:86432914-86432994 8.4e-05 67_[+5]_5 chr2:65547672-65547752 9.3e-05 12_[+5]_60 chr22:42394790-42394870 9.3e-05 25_[+5]_47 chr8:71504842-71504922 0.00011 40_[+5]_32 chr20:271432-271512 0.00011 26_[+5]_46 chrX:47003675-47003755 0.00011 46_[+5]_26 chr1:114447409-114447489 0.00012 28_[+5]_44 chr7:67981985-67982065 0.00013 65_[+5]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRSAARA MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ARRSAARA width=8 seqs=21 chr17:73187880-73187960 ( 4) AAAGAAAA 1 chr2:203776884-203776964 ( 21) AAAGAAAA 1 chr12:125354107-12535418 ( 13) AAGGAAAA 1 chr10:30638343-30638423 ( 32) AAAGAAGA 1 chr8:64058376-64058456 ( 64) AAGGAAGA 1 chr15:91593273-91593353 ( 16) AAGGAAGA 1 chr13:79233304-79233384 ( 69) AGAGAAAA 1 chr11:77530959-77531039 ( 36) AGGGAAAA 1 chr2:113239255-113239335 ( 39) AAACAAAA 1 chr6:119671601-119671681 ( 27) AAACAAAA 1 chr19:5734110-5734190 ( 7) AATGAAAA 1 chr4:147096770-147096850 ( 64) AGAGAAGA 1 chr18:72265062-72265142 ( 46) AGGGAAGA 1 chr9:86432914-86432994 ( 68) AGGGAAGA 1 chr2:65547672-65547752 ( 13) AAGCAAGA 1 chr22:42394790-42394870 ( 26) AAGCAAGA 1 chr8:71504842-71504922 ( 41) AATGAAGA 1 chr20:271432-271512 ( 27) AGGCAAAA 1 chrX:47003675-47003755 ( 47) AGGCAAAA 1 chr1:114447409-114447489 ( 29) AGTGAAAA 1 chr7:67981985-67982065 ( 66) AGACAAGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRSAARA MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.6191 E= 5.7e+003 228 -1104 -1104 -1104 147 -1104 58 -1104 88 -1104 74 -57 -1104 17 122 -1104 228 -1104 -1104 -1104 228 -1104 -1104 -1104 134 -1104 74 -1104 228 -1104 -1104 -1104 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRSAARA MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 21 E= 5.7e+003 1.000000 0.000000 0.000000 0.000000 0.571429 0.000000 0.428571 0.000000 0.380952 0.000000 0.476190 0.142857 0.000000 0.333333 0.666667 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.523810 0.000000 0.476190 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRSAARA MEME-5 regular expression -------------------------------------------------------------------------------- A[AG][GA][GC]AA[AG]A -------------------------------------------------------------------------------- Time 19.32 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr15:32907272-32907352 6.79e-02 64_[+1(4.84e-05)]_8 chr2:211342321-211342401 1.26e-02 23_[+3(3.64e-05)]_49 chrX:51486373-51486453 1.65e-01 80 chr17:30668236-30668316 1.36e-02 30_[+1(4.84e-05)]_42 chr13:43597680-43597760 4.37e-03 19_[+3(1.50e-05)]_53 chr9:88419957-88420037 3.03e-01 80 chr2:219151548-219151628 1.24e-02 80 chr6:52020031-52020111 4.88e-02 80 chr2:56346596-56346676 2.75e-01 80 chr19:39042195-39042275 5.95e-02 44_[+1(4.84e-05)]_28 chr12:118813277-11881335 6.84e-03 60_[+4(2.19e-05)]_12 chr11:8350532-8350612 2.01e-03 44_[+1(2.82e-05)]_28 chr2:9286013-9286093 5.08e-01 80 chrX:148713516-148713596 2.75e-01 80 chr9:68726380-68726460 1.32e-01 80 chr1:202523993-202524073 1.96e-02 27_[+4(8.98e-06)]_45 chr14:59113325-59113405 3.15e-02 13_[+4(5.33e-05)]_59 chr16:449017-449097 2.09e-01 30_[+2(8.62e-05)]_42 chr8:29172460-29172540 3.39e-01 80 chr1:14128463-14128543 2.00e-02 25_[+1(2.82e-05)]_47 chr13:42529807-42529887 2.22e-03 36_[+1(2.82e-05)]_36 chr15:31115774-31115854 5.39e-02 80 chr14:39901931-39902011 1.30e-01 80 chr6:161735752-161735832 1.70e-01 80 chr16:53536953-53537033 1.05e-01 13_[+4(6.26e-05)]_59 chr22:42394790-42394870 1.90e-01 25_[+5(9.26e-05)]_47 chr9:69065412-69065492 5.83e-02 80 chr18:44702668-44702748 5.99e-03 80 chr9:138904147-138904227 4.39e-02 16_[+1(4.84e-05)]_56 chr1:22546132-22546212 5.66e-03 66_[+1(4.84e-05)]_6 chr22:31608284-31608364 4.36e-01 80 chr3:72846955-72847035 1.30e-02 16_[+3(2.57e-05)]_56 chr8:9911641-9911721 1.11e-02 80 chr11:34805739-34805819 3.53e-02 54_[+3(3.64e-05)]_18 chr9:115265557-115265637 1.95e-01 80 chr6:79577217-79577297 4.11e-02 80 chr1:183204824-183204904 3.08e-01 80 chr14:54976518-54976598 6.87e-01 80 chr2:128343589-128343669 1.09e-02 80 chr2:191325468-191325548 1.07e-01 80 chr9:86432914-86432994 3.31e-03 67_[+5(8.36e-05)]_5 chr14:53620201-53620281 5.52e-01 80 chr17:62084521-62084601 9.27e-02 80 chr2:219906260-219906340 2.27e-02 80 chr17:9479170-9479250 3.44e-02 6_[+2(8.62e-05)]_66 chr15:88558636-88558716 2.43e-02 26_[+2(5.05e-05)]_46 chr8:638398-638478 2.69e-01 80 chr2:176940285-176940365 2.19e-01 80 chr16:28543582-28543662 2.96e-01 80 chrX:120490541-120490621 3.02e-01 80 chr21:34145004-34145084 5.99e-01 80 chr10:30638343-30638423 1.75e-02 31_[+5(1.70e-05)]_41 chrX:118320937-118321017 7.43e-02 80 chr15:30917909-30917989 3.50e-02 43_[+1(4.84e-05)]_29 chr1:17093231-17093311 1.55e-02 80 chr6:2766665-2766745 1.24e-01 36_[+1(4.84e-05)]_36 chr14:56643301-56643381 4.94e-02 80 chr12:4714032-4714112 1.89e-02 10_[+3(1.50e-05)]_62 chr2:207479680-207479760 1.12e-01 80 chr2:47142760-47142840 3.18e-01 80 chr19:37997944-37998024 5.24e-03 45_[+2(5.05e-05)]_27 chr12:125354107-12535418 8.13e-04 12_[+5(1.08e-05)]_43_[+4(8.98e-06)]_\ 9 chr5:86563987-86564067 6.94e-01 80 chr3:49840769-49840849 7.48e-01 80 chr22:32808268-32808348 5.43e-01 80 chr20:3828168-3828248 2.36e-02 80 chr2:203776884-203776964 6.41e-04 20_[+5(4.50e-06)]_25_[+2(5.05e-05)]_\ 19 chr2:191290148-191290228 1.38e-01 80 chr7:31174315-31174395 6.70e-02 37_[+1(7.59e-05)]_35 chr8:71504842-71504922 1.32e-01 80 chr5:132528467-132528547 2.03e-02 80 chr6:160351040-160351120 6.34e-03 14_[+2(5.05e-05)]_58 chr2:111489941-111490021 1.10e-02 61_[+1(7.59e-05)]_11 chr1:185862014-185862094 7.53e-02 80 chr2:47210481-47210561 3.42e-03 32_[+2(5.05e-05)]_40 chr1:71511505-71511585 2.44e-01 80 chrX:2511599-2511679 4.23e-01 80 chr2:48287240-48287320 2.09e-01 80 chr12:12344112-12344192 3.23e-01 80 chr10:29421364-29421444 9.04e-02 54_[+3(3.64e-05)]_18 chr2:105678189-105678269 5.79e-02 80 chr5:178450663-178450743 3.52e-01 80 chr19:14224999-14225079 4.07e-01 80 chr4:1723684-1723764 1.20e-02 62_[+1(2.82e-05)]_10 chr1:145516240-145516320 1.62e-03 62_[+3(1.50e-05)]_10 chr18:18691486-18691566 2.95e-03 1_[+3(1.50e-05)]_71 chr7:916749-916829 5.83e-01 80 chr7:67981985-67982065 2.66e-02 80 chr16:57220925-57221005 1.32e-01 80 chr17:75449814-75449894 3.72e-02 31_[+1(7.59e-05)]_41 chr6:119671601-119671681 1.09e-02 26_[+5(4.53e-05)]_46 chr16:90234827-90234907 2.88e-02 1_[+2(8.62e-05)]_71 chr9:135823447-135823527 3.21e-02 80 chr11:60621865-60621945 1.93e-02 34_[+4(3.48e-05)]_38 chr1:114447409-114447489 2.61e-03 66_[+1(4.84e-05)]_6 chr3:123751291-123751371 2.60e-02 23_[+4(7.51e-05)]_49 chr1:147230969-147231049 2.47e-01 32_[+3(6.74e-05)]_40 chr1:180123629-180123709 2.79e-03 30_[+4(5.33e-05)]_42 chr6:137539933-137540013 4.06e-01 80 chrX:11776775-11776855 1.55e-02 80 chr9:68455444-68455524 5.82e-01 80 chr16:26867553-26867633 1.31e-02 80 chrX:47003675-47003755 3.85e-02 80 chr11:111742246-11174232 9.89e-04 48_[+4(8.98e-06)]_24 chr2:87012802-87012882 1.18e-01 63_[+3(8.28e-05)]_9 chr12:112431314-11243139 1.87e-01 80 chr3:49726949-49727029 2.08e-03 14_[+3(6.74e-05)]_58 chr3:185277033-185277113 2.80e-01 80 chr2:174260679-174260759 6.59e-02 80 chr20:43160381-43160461 4.93e-01 80 chr20:16555666-16555746 5.05e-03 25_[+4(2.19e-05)]_47 chr2:109336362-109336442 7.30e-01 80 chr5:71404819-71404899 3.27e-03 22_[+4(9.68e-05)]_50 chr1:42921939-42922019 2.61e-01 80 chr6:32097836-32097916 1.97e-01 80 chr15:91593273-91593353 2.34e-03 2_[+5(9.26e-05)]_5_[+5(2.57e-05)]_\ 57 chr17:31820462-31820542 4.26e-02 80 chr3:121468119-121468199 5.07e-01 80 chr16:58767808-58767888 3.27e-01 80 chr15:64995321-64995401 1.72e-01 80 chr14:50319577-50319657 3.44e-01 80 chr9:27573789-27573869 3.89e-01 80 chr8:86895222-86895302 1.32e-01 80 chr7:73116050-73116130 5.85e-03 30_[+1(2.82e-05)]_42 chr21:44572848-44572928 7.45e-01 80 chr13:50194466-50194546 1.11e-02 54_[+4(3.48e-05)]_18 chr8:68256264-68256344 4.57e-01 80 chr11:60929727-60929807 5.63e-02 43_[+3(3.64e-05)]_29 chr8:133687839-133687919 1.71e-02 24_[+2(8.62e-05)]_48 chr3:172428912-172428992 1.41e-01 80 chr5:137475083-137475163 1.16e-01 38_[+2(5.05e-05)]_34 chr1:161499538-161499618 1.97e-03 15_[+2(2.49e-05)]_57 chr18:72265062-72265142 1.80e-02 45_[+5(8.36e-05)]_27 chr10:81838852-81838932 1.81e-01 80 chr17:30469308-30469388 6.29e-01 80 chr5:171605349-171605429 5.18e-01 80 chr6:139644897-139644977 7.59e-02 34_[+1(4.84e-05)]_38 chr8:64058376-64058456 7.45e-03 63_[+5(2.57e-05)]_9 chr16:84151171-84151251 1.47e-02 80 chr19:40779772-40779852 1.69e-01 80 chr2:200324388-200324468 3.20e-04 45_[+2(8.62e-05)]_7_[+4(5.33e-05)]_\ 12 chr22:38668655-38668735 3.82e-01 80 chr8:38458658-38458738 5.34e-02 16_[+3(6.74e-05)]_43_[+3(8.28e-05)]_\ 5 chr10:102289642-10228972 7.50e-04 13_[+2(8.62e-05)]_7_[+4(5.33e-05)]_\ 44 chr19:5734110-5734190 3.77e-02 6_[+5(5.64e-05)]_66 chr18:44498039-44498119 3.09e-01 80 chr17:73187880-73187960 1.19e-04 3_[+5(4.50e-06)]_17_[+2(5.05e-05)]_\ 44 chr20:271432-271512 1.13e-02 80 chr15:78555872-78555952 5.96e-01 80 chr1:109060310-109060390 5.23e-01 80 chr2:75873811-75873891 3.12e-04 29_[+3(1.50e-05)]_43 chr14:102785946-10278602 6.28e-02 80 chr8:100905939-100906019 8.45e-02 80 chr11:57001235-57001315 1.78e-03 2_[+2(8.62e-05)]_70 chr8:59397269-59397349 4.28e-02 80 chr10:127585053-12758513 1.43e-01 80 chr2:181826115-181826195 9.79e-03 80 chr20:44614398-44614478 1.73e-01 80 chr3:140629781-140629861 2.63e-01 80 chr1:110198696-110198776 5.16e-01 80 chr2:62081298-62081378 8.75e-02 80 chr16:53468266-53468346 1.41e-02 2_[+3(6.74e-05)]_70 chr17:2207050-2207130 9.58e-01 80 chr1:43990662-43990742 3.21e-01 80 chr1:166136136-166136216 9.20e-01 80 chr2:113239255-113239335 1.14e-02 38_[+5(4.53e-05)]_34 chr4:185187229-185187309 4.77e-03 46_[+1(4.84e-05)]_26 chr17:37037881-37037961 1.40e-02 80 chr15:101142324-10114240 9.22e-03 67_[+1(7.59e-05)]_5 chr2:42775056-42775136 8.00e-03 80 chr20:42939766-42939846 1.26e-01 36_[+1(7.59e-05)]_21_[+1(7.59e-05)]_\ 7 chr6:28778740-28778820 7.58e-01 80 chr13:79233304-79233384 9.54e-03 68_[+5(3.19e-05)]_4 chr7:89874398-89874478 2.97e-01 80 chr5:130969666-130969746 1.29e-03 35_[+1(4.84e-05)]_37 chr1:117169680-117169760 2.25e-01 80 chr13:26760718-26760798 6.73e-02 80 chrX:150151577-150151657 7.46e-03 26_[+1(2.82e-05)]_46 chr22:31885803-31885883 6.33e-02 80 chr4:113558646-113558726 8.00e-02 80 chr13:41635589-41635669 3.87e-01 80 chr15:25123493-25123573 2.51e-01 80 chr13:28024652-28024732 3.19e-01 80 chr19:17355229-17355309 1.00e-02 12_[+1(2.82e-05)]_60 chr2:45805767-45805847 1.69e-03 49_[+4(8.98e-06)]_23 chr11:77530959-77531039 8.57e-03 35_[+5(4.53e-05)]_1_[+4(6.26e-05)]_\ 28 chr15:34806592-34806672 1.61e-01 80 chr19:52430627-52430707 3.18e-01 80 chr7:129592146-129592226 8.44e-03 80 chr1:154833106-154833186 8.08e-02 80 chr20:33296975-33297055 7.38e-01 80 chr11:62779892-62779972 1.36e-01 80 chr8:74658930-74659010 7.58e-01 80 chr12:122690046-12269012 2.40e-02 24_[+4(8.98e-06)]_48 chr15:25018318-25018398 4.96e-02 38_[+2(5.05e-05)]_34 chr10:77268897-77268977 1.58e-01 34_[+1(7.59e-05)]_38 chr4:185158902-185158982 1.95e-02 80 chr13:108870609-10887068 6.19e-02 80 chr19:200361-200441 6.68e-01 80 chr1:118251348-118251428 6.57e-01 80 chr15:78832981-78833061 8.76e-01 80 chrX:119737680-119737760 1.01e-01 80 chr4:147096770-147096850 4.40e-03 63_[+5(6.51e-05)]_9 chr2:65547672-65547752 4.16e-02 12_[+5(9.26e-05)]_60 chr3:24415125-24415205 6.21e-01 80 chr10:104192469-10419254 3.75e-01 80 chr3:191047100-191047180 3.16e-01 80 chr20:25388239-25388319 6.78e-01 80 chr20:35807991-35808071 5.86e-01 80 chr18:10525928-10526008 5.19e-01 80 chr1:151300233-151300313 2.39e-01 80 chrX:84258860-84258940 9.21e-04 6_[+3(1.50e-05)]_66 chr13:103046935-10304701 8.18e-02 11_[+2(8.62e-05)]_61 chrX:23925893-23925973 4.87e-01 80 chr16:67450402-67450482 8.86e-02 23_[+4(5.33e-05)]_49 chr15:101792139-10179221 9.03e-01 80 chr5:115420633-115420713 2.53e-01 80 chr20:29611717-29611797 6.66e-01 80 chr6:38607343-38607423 3.14e-01 80 chr21:34494351-34494431 3.20e-01 28_[+1(7.59e-05)]_44 chr5:180258673-180258753 6.93e-01 80 chrX:38186822-38186902 2.59e-02 33_[+2(2.49e-05)]_39 chr1:161147084-161147164 5.96e-01 80 chr1:18993985-18994065 5.58e-02 54_[+4(6.26e-05)]_18 chr14:55337571-55337651 6.68e-02 43_[+1(2.82e-05)]_29 chr2:202645774-202645854 2.25e-03 36_[+4(8.43e-05)]_36 chr4:123523983-123524063 6.71e-01 80 chr14:54955760-54955840 1.82e-01 80 chr19:49658484-49658564 4.07e-02 56_[+4(2.19e-05)]_16 chr12:21590482-21590562 5.86e-01 80 chr13:45694536-45694616 6.50e-01 80 chr12:110338033-11033811 1.91e-01 80 chr2:207024141-207024221 9.87e-02 80 chr1:116961208-116961288 2.52e-02 44_[+2(8.62e-05)]_28 chr6:150067718-150067798 1.46e-01 18_[+2(5.05e-05)]_54 chr2:15701437-15701517 6.63e-04 69_[+3(8.28e-05)]_3 chr11:71814088-71814168 2.16e-02 23_[+1(2.82e-05)]_49 chr14:57735687-57735767 1.29e-03 10_[+1(9.55e-05)]_62 chr9:5833098-5833178 4.86e-03 43_[+4(5.33e-05)]_29 chr7:37745815-37745895 5.52e-03 45_[+4(7.51e-05)]_27 chr19:44037264-44037344 5.06e-03 28_[+1(7.59e-05)]_44 chr1:174972200-174972280 1.27e-01 29_[+4(7.51e-05)]_43 chr18:43547312-43547392 5.01e-02 47_[+4(2.19e-05)]_25 chr15:75743756-75743836 4.33e-01 80 chr15:50672392-50672472 3.62e-04 19_[+5(5.64e-05)]_35_[+3(2.57e-05)]_\ 10 chr11:18610232-18610312 4.09e-02 80 chr2:242089009-242089089 6.53e-02 80 chr2:232826333-232826413 1.41e-01 44_[+1(7.59e-05)]_28 chr19:49128371-49128451 3.49e-01 80 chr22:48027353-48027433 9.74e-03 27_[+3(3.64e-05)]_45 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n05.farnam.hpc.yale.internal ********************************************************************************