******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/ZNF280A.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr11:63267511-63267591 1.0000 80 chr16:87851152-87851232 1.0000 80 chr22:46967705-46967785 1.0000 80 chr10:13125850-13125930 1.0000 80 chr5:81543133-81543213 1.0000 80 chr5:40877644-40877724 1.0000 80 chr11:12510983-12511063 1.0000 80 chr21:43261129-43261209 1.0000 80 chr11:66350128-66350208 1.0000 80 chr15:51777121-51777201 1.0000 80 chr16:72083184-72083264 1.0000 80 chr16:31860023-31860103 1.0000 80 chr7:44564574-44564654 1.0000 80 chr22:20728597-20728677 1.0000 80 chr12:62857176-62857256 1.0000 80 chr6:29661565-29661645 1.0000 80 chr8:99238159-99238239 1.0000 80 chr4:38714474-38714554 1.0000 80 chr1:16429713-16429793 1.0000 80 chr20:57061466-57061546 1.0000 80 chr7:154726146-154726226 1.0000 80 chr15:102163817-10216389 1.0000 80 chr14:21296457-21296537 1.0000 80 chrX:155097640-155097720 1.0000 80 chr9:100166242-100166322 1.0000 80 chr4:89041220-89041300 1.0000 80 chr20:62548021-62548101 1.0000 80 chr10:22295479-22295559 1.0000 80 chr2:198348420-198348500 1.0000 80 chr7:102904658-102904738 1.0000 80 chr7:29946027-29946107 1.0000 80 chr1:213199196-213199276 1.0000 80 chr6:49816974-49817054 1.0000 80 chr2:109323950-109324030 1.0000 80 chr1:228432886-228432966 1.0000 80 chr15:96244774-96244854 1.0000 80 chr12:31761413-31761493 1.0000 80 chr19:758920-759000 1.0000 80 chr3:152564744-152564824 1.0000 80 chr17:55326895-55326975 1.0000 80 chr2:98502410-98502490 1.0000 80 chr5:34782235-34782315 1.0000 80 chr2:86498513-86498593 1.0000 80 chr12:22765935-22766015 1.0000 80 chr3:142892249-142892329 1.0000 80 chr9:135971655-135971735 1.0000 80 chr7:137974777-137974857 1.0000 80 chr7:23693729-23693809 1.0000 80 chr11:77556375-77556455 1.0000 80 chr8:92027836-92027916 1.0000 80 chr8:100768413-100768493 1.0000 80 chr6:33120089-33120169 1.0000 80 chr4:152470026-152470106 1.0000 80 chr22:42500502-42500582 1.0000 80 chr1:228431758-228431838 1.0000 80 chr1:55399900-55399980 1.0000 80 chr17:27361693-27361773 1.0000 80 chr5:53252626-53252706 1.0000 80 chr2:26303953-26304033 1.0000 80 chr17:35704105-35704185 1.0000 80 chr16:50475925-50476005 1.0000 80 chr2:99887518-99887598 1.0000 80 chr21:39470055-39470135 1.0000 80 chr2:70879019-70879099 1.0000 80 chr1:46849497-46849577 1.0000 80 chr4:1176287-1176367 1.0000 80 chr10:71248750-71248830 1.0000 80 chr13:21344165-21344245 1.0000 80 chr11:76046199-76046279 1.0000 80 chr1:211714321-211714401 1.0000 80 chr7:72311881-72311961 1.0000 80 chr8:100697792-100697872 1.0000 80 chr1:26270029-26270109 1.0000 80 chr11:5825361-5825441 1.0000 80 chr17:29965593-29965673 1.0000 80 chr7:67731161-67731241 1.0000 80 chr1:184963575-184963655 1.0000 80 chr12:51259163-51259243 1.0000 80 chr3:136372615-136372695 1.0000 80 chr5:56365088-56365168 1.0000 80 chr1:114171745-114171825 1.0000 80 chr10:22224521-22224601 1.0000 80 chr8:125924028-125924108 1.0000 80 chr10:121404663-12140474 1.0000 80 chr1:167785049-167785129 1.0000 80 chr2:178296119-178296199 1.0000 80 chr19:12244051-12244131 1.0000 80 chr7:66541274-66541354 1.0000 80 chr5:90539214-90539294 1.0000 80 chr12:9506844-9506924 1.0000 80 chr19:1695651-1695731 1.0000 80 chr7:72200975-72201055 1.0000 80 chr19:44536318-44536398 1.0000 80 chr1:145673306-145673386 1.0000 80 chr1:247193053-247193133 1.0000 80 chr3:47569591-47569671 1.0000 80 chr6:170902582-170902662 1.0000 80 chr5:53633510-53633590 1.0000 80 chr3:12608018-12608098 1.0000 80 chr19:11979124-11979204 1.0000 80 chr20:41962861-41962941 1.0000 80 chr1:33530006-33530086 1.0000 80 chr2:10656124-10656204 1.0000 80 chr1:211346032-211346112 1.0000 80 chr6:158718945-158719025 1.0000 80 chr6:160269687-160269767 1.0000 80 chr8:18008717-18008797 1.0000 80 chr12:807556-807636 1.0000 80 chr8:56457768-56457848 1.0000 80 chr16:15910271-15910351 1.0000 80 chr22:18147381-18147461 1.0000 80 chr11:10894706-10894786 1.0000 80 chr8:91789714-91789794 1.0000 80 chr7:72802489-72802569 1.0000 80 chr2:219216457-219216537 1.0000 80 chr15:56566053-56566133 1.0000 80 chr1:44274976-44275056 1.0000 80 chr8:140873373-140873453 1.0000 80 chr2:172287497-172287577 1.0000 80 chr8:144054838-144054918 1.0000 80 chr5:43336318-43336398 1.0000 80 chr19:9926222-9926302 1.0000 80 chr1:108732994-108733074 1.0000 80 chr16:71193489-71193569 1.0000 80 chr12:131882205-13188228 1.0000 80 chr5:126857213-126857293 1.0000 80 chr4:73360048-73360128 1.0000 80 chr20:55096189-55096269 1.0000 80 chr13:21139641-21139721 1.0000 80 chr4:73403840-73403920 1.0000 80 chr1:30565452-30565532 1.0000 80 chr1:174284501-174284581 1.0000 80 chr6:111243914-111243994 1.0000 80 chr19:9524020-9524100 1.0000 80 chr1:180627959-180628039 1.0000 80 chr18:9503041-9503121 1.0000 80 chrX:70546387-70546467 1.0000 80 chr10:52111372-52111452 1.0000 80 chr5:54668546-54668626 1.0000 80 chr1:147149946-147150026 1.0000 80 chr19:39426066-39426146 1.0000 80 chr18:3523896-3523976 1.0000 80 chr1:211867434-211867514 1.0000 80 chr7:138051614-138051694 1.0000 80 chr1:244737227-244737307 1.0000 80 chr2:112384546-112384626 1.0000 80 chr3:197694619-197694699 1.0000 80 chr19:9597848-9597928 1.0000 80 chr12:50886017-50886097 1.0000 80 chr17:38917018-38917098 1.0000 80 chr10:72525913-72525993 1.0000 80 chr6:41182442-41182522 1.0000 80 chr18:10357054-10357134 1.0000 80 chr9:91034348-91034428 1.0000 80 chr19:46589350-46589430 1.0000 80 chr15:89508491-89508571 1.0000 80 chr16:16076115-16076195 1.0000 80 chr3:45319227-45319307 1.0000 80 chr3:32084474-32084554 1.0000 80 chr2:109486682-109486762 1.0000 80 chr7:5104757-5104837 1.0000 80 chr3:172718531-172718611 1.0000 80 chr5:150211567-150211647 1.0000 80 chr12:51306303-51306383 1.0000 80 chr1:118313874-118313954 1.0000 80 chr22:21332908-21332988 1.0000 80 chr17:47262911-47262991 1.0000 80 chr6:170899936-170900016 1.0000 80 chr19:33382676-33382756 1.0000 80 chr1:110480515-110480595 1.0000 80 chr3:143277012-143277092 1.0000 80 chr4:128917827-128917907 1.0000 80 chr11:2652539-2652619 1.0000 80 chr14:69268492-69268572 1.0000 80 chr6:86292711-86292791 1.0000 80 chr19:15627328-15627408 1.0000 80 chr17:15620387-15620467 1.0000 80 chr11:32390422-32390502 1.0000 80 chr3:12906921-12907001 1.0000 80 chr19:35408187-35408267 1.0000 80 chr2:130676338-130676418 1.0000 80 chr8:97667531-97667611 1.0000 80 chr15:93493007-93493087 1.0000 80 chr5:180198976-180199056 1.0000 80 chr8:143409873-143409953 1.0000 80 chr6:4630173-4630253 1.0000 80 chr11:118542143-11854222 1.0000 80 chr19:35040888-35040968 1.0000 80 chr21:45039951-45040031 1.0000 80 chr19:35041089-35041169 1.0000 80 chr2:131712588-131712668 1.0000 80 chr4:184305540-184305620 1.0000 80 chr15:70217020-70217100 1.0000 80 chr15:27980378-27980458 1.0000 80 chr12:104628847-10462892 1.0000 80 chr4:72729313-72729393 1.0000 80 chr10:35728269-35728349 1.0000 80 chr7:33158153-33158233 1.0000 80 chr6:36146479-36146559 1.0000 80 chr11:33953437-33953517 1.0000 80 chr4:56704209-56704289 1.0000 80 chr1:172589924-172590004 1.0000 80 chr3:36962813-36962893 1.0000 80 chr10:38407148-38407228 1.0000 80 chrX:123279756-123279836 1.0000 80 chr3:45412600-45412680 1.0000 80 chr2:173439880-173439960 1.0000 80 chr1:154049058-154049138 1.0000 80 chr1:94916000-94916080 1.0000 80 chr11:61788971-61789051 1.0000 80 chr2:72989585-72989665 1.0000 80 chr7:3821413-3821493 1.0000 80 chr1:207302488-207302568 1.0000 80 chr1:46859249-46859329 1.0000 80 chr7:130016466-130016546 1.0000 80 chr18:32785421-32785501 1.0000 80 chr22:19922733-19922813 1.0000 80 chr1:117409253-117409333 1.0000 80 chr22:18968515-18968595 1.0000 80 chr12:116376902-11637698 1.0000 80 chr12:110595563-11059564 1.0000 80 chr7:158813707-158813787 1.0000 80 chr1:40941133-40941213 1.0000 80 chr5:112190504-112190584 1.0000 80 chr1:9091306-9091386 1.0000 80 chr7:130541782-130541862 1.0000 80 chr4:39372999-39373079 1.0000 80 chr1:203064335-203064415 1.0000 80 chr5:74765032-74765112 1.0000 80 chr1:32924539-32924619 1.0000 80 chr11:74577770-74577850 1.0000 80 chr11:69507356-69507436 1.0000 80 chr1:20344392-20344472 1.0000 80 chr22:19152094-19152174 1.0000 80 chr19:47101933-47102013 1.0000 80 chr19:11728491-11728571 1.0000 80 chr1:32862227-32862307 1.0000 80 chr7:129898503-129898583 1.0000 80 chr17:19882127-19882207 1.0000 80 chr2:100780220-100780300 1.0000 80 chr15:82211248-82211328 1.0000 80 chr6:138177372-138177452 1.0000 80 chr7:23698810-23698890 1.0000 80 chr19:35061216-35061296 1.0000 80 chr2:173442918-173442998 1.0000 80 chr2:65271377-65271457 1.0000 80 chr3:141347882-141347962 1.0000 80 chr8:11190699-11190779 1.0000 80 chr22:45007929-45008009 1.0000 80 chr18:48503571-48503651 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_ZNF280A/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/ZNF280A.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.304 C 0.203 G 0.204 T 0.288 Background letter frequencies (from file dataset with add-one prior applied): A 0.304 C 0.204 G 0.204 T 0.288 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TTCTGCAG MEME-1 width = 8 sites = 105 llr = 856 E-value = 9.2e-083 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 Description -------------------------------------------------------------------------------- Simplified A :1:11:8: pos.-specific C 11a::9:: probability G 11::8::a matrix T 98:9:12: bits 2.3 * 2.1 * * 1.8 * * 1.6 * * * Relative 1.4 **** * Entropy 1.1 * ****** (11.8 bits) 0.9 * ****** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTCTGCAG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:45007929-45008009 39 1.26e-05 caactttgct ttctgcag aaagggtgct chr7:23698810-23698890 31 1.26e-05 agtggcaccc ttctgcag aagtaaatgg chr15:82211248-82211328 53 1.26e-05 ggcagaagtt ttctgcag gggtggagcc chr17:19882127-19882207 62 1.26e-05 aatctttact ttctgcag aaagggtgct chrX:123279756-123279836 29 1.26e-05 aatagtaccc ttctgcag aagtaaattg chr12:104628847-10462892 40 1.26e-05 gcaaatttac ttctgcag aaaggtgctg chr6:4630173-4630253 44 1.26e-05 caattttact ttctgcag aaagggtgct chr8:143409873-143409953 42 1.26e-05 gcagcacccc ttctgcag aaagtaaaat chr15:93493007-93493087 35 1.26e-05 caattttact ttctgcag aaagggtgct chr19:35408187-35408267 62 1.26e-05 tttttatgct ttctgcag aaagggtaca chr3:12906921-12907001 35 1.26e-05 agtgacaccc ttctgcag aagtaaattg chr5:150211567-150211647 31 1.26e-05 tttttatact ttctgcag aaagggtaca chr6:41182442-41182522 31 1.26e-05 aatttttact ttctgcag aaagggtgct chr19:9597848-9597928 47 1.26e-05 ggaccaccct ttctgcag aaagtaaaat chr1:244737227-244737307 38 1.26e-05 cagttttagt ttctgcag aaagggtgct chr1:147149946-147150026 56 1.26e-05 catttttact ttctgcag aaagggtaca chr1:30565452-30565532 54 1.26e-05 aatttttact ttctgcag aaagggtgct chr8:144054838-144054918 43 1.26e-05 aacagcaccc ttctgcag aagaaaattg chr8:140873373-140873453 39 1.26e-05 aatttttact ttctgcag aaagggtgct chr12:807556-807636 29 1.26e-05 agtgtaccct ttctgcag aaagtgaaaa chr7:72200975-72201055 37 1.26e-05 tttttttact ttctgcag aaagggtaca chr7:66541274-66541354 25 1.26e-05 agtgtaccct ttctgcag aaagtaaaaa chr10:121404663-12140474 53 1.26e-05 caattttact ttctgcag aaagggtgct chr8:125924028-125924108 24 1.26e-05 tgagcaccct ttctgcag aaagtaaaga chr7:67731161-67731241 45 1.26e-05 ggagcaccct ttctgcag aaagtaaaaa chr11:5825361-5825441 46 1.26e-05 ggcaatttac ttctgcag aagggtgcca chr22:42500502-42500582 38 1.26e-05 ggcaatttac ttctgcag aagggtgctg chr4:152470026-152470106 33 1.26e-05 aacttttact ttctgcag aaagggtgcc chr8:92027836-92027916 34 1.26e-05 tttttatact ttctgcag aaagggtaca chr7:23693729-23693809 11 1.26e-05 agtggcaccc ttctgcag aagtaaattg chr12:31761413-31761493 43 1.26e-05 ggagcaccct ttctgcag aaggtaaaat chr2:198348420-198348500 38 1.26e-05 agtgtaccct ttctgcag aaagtaaaaa chr16:31860023-31860103 57 1.26e-05 ggagcaccct ttctgcag aaagtaaaat chr16:72083184-72083264 20 1.26e-05 tgggcaccct ttctgcag aaagtaaaaa chr10:13125850-13125930 53 1.26e-05 ggagcaccct ttctgcag aaagtaaaat chr22:46967705-46967785 17 1.26e-05 tgagcaccct ttctgcag aaagtaaaaa chr16:87851152-87851232 20 1.26e-05 agtgtaccct ttctgcag aaagtaaaaa chr11:63267511-63267591 30 1.26e-05 agtgtaccct ttctgcag aaagtataaa chr10:72525913-72525993 53 2.15e-05 ggcagaagtc tgctgcag gggcagagcc chr6:170902582-170902662 24 2.15e-05 catgtcacag tgctgcag agattttgtt chr11:76046199-76046279 58 2.15e-05 ggcagaagtc tgctgcag gggtggagcc chr5:34782235-34782315 62 2.15e-05 catgtcacag tgctgcag agattttgtt chr3:152564744-152564824 21 2.15e-05 ggcagaaggt tgctgcag gggtggggcc chr1:213199196-213199276 65 2.15e-05 catgttacag tgctgcag agattttg chr1:16429713-16429793 37 2.15e-05 catgtcacag tgctgcag agattttgtt chr10:35728269-35728349 46 3.34e-05 ctttcttctg ttctgctg ttgagcacat chr1:114171745-114171825 70 3.34e-05 acttgatcga ttctgctg tta chr8:100697792-100697872 54 3.34e-05 gcttgatcaa ttctgctg ttaagagact chr8:99238159-99238239 53 3.34e-05 gcttgatcat ttctgctg ttaagagact chr19:35061216-35061296 30 4.23e-05 acgccctgtc tcctgcag tatgctcagg chr18:9503041-9503121 57 4.23e-05 cgccctggtc tcctgcag tacactcagg chr8:56457768-56457848 47 4.23e-05 tgccctggtc tcctgcag cacccccagg chr11:66350128-66350208 63 4.23e-05 catttttact tcctgcag aaagggtata chrX:70546387-70546467 42 7.88e-05 ggagcaccct ttctgtag aaagtaaaat chr12:9506844-9506924 35 7.88e-05 ggcaatttac ttctacag aagggtgcat chr14:21296457-21296537 38 7.88e-05 gcaatgtact ttctacag aagggtgcac chr1:9091306-9091386 70 1.01e-04 ggtagctcct ctctgcag ctg chr7:158813707-158813787 49 1.01e-04 AGTAACTCct ctctgcag gccggtcttc chr12:51306303-51306383 13 1.01e-04 agcctgaggg tactgcag gagaccaggg chr8:91789714-91789794 22 1.01e-04 agcctgaggg tactgcag gagaccaggg chr17:29965593-29965673 14 1.01e-04 taaacaaaat ctctgcag cactgtgaca chr10:71248750-71248830 30 1.01e-04 atcctgaggg tactgcag gagaccaggg chr20:62548021-62548101 19 1.01e-04 agcctgaggg tactgcag gagaccaggg chr4:72729313-72729393 3 1.10e-04 at gtctgcag cactgtgaca chr1:40941133-40941213 66 1.23e-04 ttattctaca ttcagcag tgtctaa chr7:3821413-3821493 12 1.23e-04 aatagaaagc ttcagcag aagacactgt chr19:46589350-46589430 46 1.41e-04 attcaatgga ttcttcag ttctagaatt chr4:73360048-73360128 61 1.41e-04 attcattgta ttcttcag ctccagaatt chr11:10894706-10894786 60 1.41e-04 attcatcaaa ttcttcag ttccaggatt chr11:2652539-2652619 52 1.49e-04 tgatcaagtc tgctgctg atgctttcta chr4:39372999-39373079 28 1.84e-04 ggcagaagtt tgctgtag gggcggagcc chr3:143277012-143277092 58 1.84e-04 ggcagaagtt tgctacag cagtggagcc chr19:35040888-35040968 32 2.37e-04 atcttctgta ttctgttg ataagcccat chr2:10656124-10656204 61 2.37e-04 attttcatct ttctgttg ttctgtgcta chr1:211714321-211714401 60 2.37e-04 gagagagagc ttgtgcag ggaaactccc chr1:55399900-55399980 58 2.37e-04 aagagagagc ttgtgcag ggacactttt chr19:47101933-47102013 35 2.64e-04 gcttgaccca ctctgctg ttgagaacct chr4:184305540-184305620 36 2.64e-04 cgggtctcct ctctgctg agagctggat chr7:72802489-72802569 41 2.64e-04 agtttaaatc tactgctg tacttctagt chr8:97667531-97667611 40 2.73e-04 gcttaattga gtctgctg ttgaagattt chr22:21332908-21332988 46 2.73e-04 ACACCTGAGG GTCTGCTG CTTGAAACCC chr17:38917018-38917098 37 2.73e-04 gcatgataga gtctgctg ttgaagcttt chr9:100166242-100166322 51 2.99e-04 cttgatggtg tcctacag ggcccttagc chr2:65271377-65271457 54 3.41e-04 caatttttac ttctatag aagagtgtaa chr1:46859249-46859329 18 3.41e-04 ggcaatttac ttctatag aagggtgcgc chr11:33953437-33953517 39 3.41e-04 caatttttac ttctatag aagggtgcga chr11:32390422-32390502 28 3.41e-04 agggccccac ccctgcag caaacttctg chr9:91034348-91034428 48 3.41e-04 gggcgcaccc ttctatag aagtaaattg chr13:21139641-21139721 26 3.41e-04 gggcgcaccc ttctatag aagtaaattg chr5:126857213-126857293 29 3.41e-04 agacacaccc ttctatag aagtaaaatt chr12:131882205-13188228 43 3.41e-04 gctccaccca tgcagcag acttctgcct chr5:56365088-56365168 64 3.41e-04 caatttttac ttctatag aagggtgcg chr7:137974777-137974857 39 3.41e-04 agacacaccc ttctatag aagtaaattg chrX:155097640-155097720 34 3.41e-04 gcaattttac ttctatag aagggtgtgt chr7:154726146-154726226 45 3.41e-04 agggctccac ccctgcag cagacttctg chr16:50475925-50476005 7 4.24e-04 gagctg tactgtag ctcaataaag chr6:29661565-29661645 43 4.24e-04 tgttaaagct ttcagctg catttggaac chr4:128917827-128917907 68 4.59e-04 cagagcagct gtctgtag accta chr2:72989585-72989665 18 4.82e-04 aagaaagaat gactgcag acttctcatc chr19:39426066-39426146 4 4.82e-04 gtt atctgcag caggaacatg chr5:112190504-112190584 32 5.59e-04 agtttgctca ttcttctg tccgttcaaa chr1:154049058-154049138 13 5.59e-04 actagaggaa ttcaacag cagatttgaa chr2:109486682-109486762 11 5.59e-04 actagaagag ttcaacag cagacttgaa chr2:70879019-70879099 34 5.59e-04 caccaacctt ttcttctg cgatgtctaa chr1:108732994-108733074 12 5.83e-04 ttggggctgt tacagcag ttattgcata -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:45007929-45008009 1.3e-05 38_[+1]_34 chr7:23698810-23698890 1.3e-05 30_[+1]_42 chr15:82211248-82211328 1.3e-05 52_[+1]_20 chr17:19882127-19882207 1.3e-05 61_[+1]_11 chrX:123279756-123279836 1.3e-05 28_[+1]_44 chr12:104628847-10462892 1.3e-05 39_[+1]_33 chr6:4630173-4630253 1.3e-05 43_[+1]_29 chr8:143409873-143409953 1.3e-05 41_[+1]_31 chr15:93493007-93493087 1.3e-05 34_[+1]_38 chr19:35408187-35408267 1.3e-05 61_[+1]_11 chr3:12906921-12907001 1.3e-05 34_[+1]_38 chr5:150211567-150211647 1.3e-05 30_[+1]_42 chr6:41182442-41182522 1.3e-05 30_[+1]_42 chr19:9597848-9597928 1.3e-05 46_[+1]_26 chr1:244737227-244737307 1.3e-05 37_[+1]_35 chr1:147149946-147150026 1.3e-05 55_[+1]_17 chr1:30565452-30565532 1.3e-05 53_[+1]_19 chr8:144054838-144054918 1.3e-05 42_[+1]_30 chr8:140873373-140873453 1.3e-05 38_[+1]_34 chr12:807556-807636 1.3e-05 28_[+1]_44 chr7:72200975-72201055 1.3e-05 36_[+1]_36 chr7:66541274-66541354 1.3e-05 24_[+1]_48 chr10:121404663-12140474 1.3e-05 52_[+1]_20 chr8:125924028-125924108 1.3e-05 23_[+1]_49 chr7:67731161-67731241 1.3e-05 44_[+1]_28 chr11:5825361-5825441 1.3e-05 45_[+1]_27 chr22:42500502-42500582 1.3e-05 37_[+1]_35 chr4:152470026-152470106 1.3e-05 32_[+1]_40 chr8:92027836-92027916 1.3e-05 33_[+1]_39 chr7:23693729-23693809 1.3e-05 10_[+1]_62 chr12:31761413-31761493 1.3e-05 42_[+1]_30 chr2:198348420-198348500 1.3e-05 37_[+1]_35 chr16:31860023-31860103 1.3e-05 56_[+1]_16 chr16:72083184-72083264 1.3e-05 19_[+1]_53 chr10:13125850-13125930 1.3e-05 52_[+1]_20 chr22:46967705-46967785 1.3e-05 16_[+1]_56 chr16:87851152-87851232 1.3e-05 19_[+1]_53 chr11:63267511-63267591 1.3e-05 29_[+1]_43 chr10:72525913-72525993 2.1e-05 52_[+1]_20 chr6:170902582-170902662 2.1e-05 23_[+1]_49 chr11:76046199-76046279 2.1e-05 57_[+1]_15 chr5:34782235-34782315 2.1e-05 61_[+1]_11 chr3:152564744-152564824 2.1e-05 20_[+1]_52 chr1:213199196-213199276 2.1e-05 64_[+1]_8 chr1:16429713-16429793 2.1e-05 36_[+1]_36 chr10:35728269-35728349 3.3e-05 45_[+1]_27 chr1:114171745-114171825 3.3e-05 69_[+1]_3 chr8:100697792-100697872 3.3e-05 53_[+1]_19 chr8:99238159-99238239 3.3e-05 52_[+1]_20 chr19:35061216-35061296 4.2e-05 29_[+1]_43 chr18:9503041-9503121 4.2e-05 56_[+1]_16 chr8:56457768-56457848 4.2e-05 46_[+1]_26 chr11:66350128-66350208 4.2e-05 62_[+1]_10 chrX:70546387-70546467 7.9e-05 41_[+1]_31 chr12:9506844-9506924 7.9e-05 34_[+1]_38 chr14:21296457-21296537 7.9e-05 37_[+1]_35 chr1:9091306-9091386 0.0001 69_[+1]_3 chr7:158813707-158813787 0.0001 48_[+1]_24 chr12:51306303-51306383 0.0001 12_[+1]_60 chr8:91789714-91789794 0.0001 21_[+1]_51 chr17:29965593-29965673 0.0001 13_[+1]_59 chr10:71248750-71248830 0.0001 29_[+1]_43 chr20:62548021-62548101 0.0001 18_[+1]_54 chr4:72729313-72729393 0.00011 2_[+1]_70 chr1:40941133-40941213 0.00012 65_[+1]_7 chr7:3821413-3821493 0.00012 11_[+1]_61 chr19:46589350-46589430 0.00014 45_[+1]_27 chr4:73360048-73360128 0.00014 60_[+1]_12 chr11:10894706-10894786 0.00014 59_[+1]_13 chr11:2652539-2652619 0.00015 51_[+1]_21 chr4:39372999-39373079 0.00018 27_[+1]_45 chr3:143277012-143277092 0.00018 57_[+1]_15 chr19:35040888-35040968 0.00024 31_[+1]_41 chr2:10656124-10656204 0.00024 60_[+1]_12 chr1:211714321-211714401 0.00024 59_[+1]_13 chr1:55399900-55399980 0.00024 57_[+1]_15 chr19:47101933-47102013 0.00026 34_[+1]_38 chr4:184305540-184305620 0.00026 35_[+1]_37 chr7:72802489-72802569 0.00026 40_[+1]_32 chr8:97667531-97667611 0.00027 39_[+1]_33 chr22:21332908-21332988 0.00027 45_[+1]_27 chr17:38917018-38917098 0.00027 36_[+1]_36 chr9:100166242-100166322 0.0003 50_[+1]_22 chr2:65271377-65271457 0.00034 53_[+1]_19 chr1:46859249-46859329 0.00034 17_[+1]_55 chr11:33953437-33953517 0.00034 38_[+1]_34 chr11:32390422-32390502 0.00034 27_[+1]_45 chr9:91034348-91034428 0.00034 47_[+1]_25 chr13:21139641-21139721 0.00034 25_[+1]_47 chr5:126857213-126857293 0.00034 28_[+1]_44 chr12:131882205-13188228 0.00034 42_[+1]_30 chr5:56365088-56365168 0.00034 63_[+1]_9 chr7:137974777-137974857 0.00034 38_[+1]_34 chrX:155097640-155097720 0.00034 33_[+1]_39 chr7:154726146-154726226 0.00034 44_[+1]_28 chr16:50475925-50476005 0.00042 6_[+1]_66 chr6:29661565-29661645 0.00042 42_[+1]_30 chr4:128917827-128917907 0.00046 67_[+1]_5 chr2:72989585-72989665 0.00048 17_[+1]_55 chr19:39426066-39426146 0.00048 3_[+1]_69 chr5:112190504-112190584 0.00056 31_[+1]_41 chr1:154049058-154049138 0.00056 12_[+1]_60 chr2:109486682-109486762 0.00056 10_[+1]_62 chr2:70879019-70879099 0.00056 33_[+1]_39 chr1:108732994-108733074 0.00058 11_[+1]_61 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTCTGCAG width=8 seqs=105 chr22:45007929-45008009 ( 39) TTCTGCAG 1 chr7:23698810-23698890 ( 31) TTCTGCAG 1 chr15:82211248-82211328 ( 53) TTCTGCAG 1 chr17:19882127-19882207 ( 62) TTCTGCAG 1 chrX:123279756-123279836 ( 29) TTCTGCAG 1 chr12:104628847-10462892 ( 40) TTCTGCAG 1 chr6:4630173-4630253 ( 44) TTCTGCAG 1 chr8:143409873-143409953 ( 42) TTCTGCAG 1 chr15:93493007-93493087 ( 35) TTCTGCAG 1 chr19:35408187-35408267 ( 62) TTCTGCAG 1 chr3:12906921-12907001 ( 35) TTCTGCAG 1 chr5:150211567-150211647 ( 31) TTCTGCAG 1 chr6:41182442-41182522 ( 31) TTCTGCAG 1 chr19:9597848-9597928 ( 47) TTCTGCAG 1 chr1:244737227-244737307 ( 38) TTCTGCAG 1 chr1:147149946-147150026 ( 56) TTCTGCAG 1 chr1:30565452-30565532 ( 54) TTCTGCAG 1 chr8:144054838-144054918 ( 43) TTCTGCAG 1 chr8:140873373-140873453 ( 39) TTCTGCAG 1 chr12:807556-807636 ( 29) TTCTGCAG 1 chr7:72200975-72201055 ( 37) TTCTGCAG 1 chr7:66541274-66541354 ( 25) TTCTGCAG 1 chr10:121404663-12140474 ( 53) TTCTGCAG 1 chr8:125924028-125924108 ( 24) TTCTGCAG 1 chr7:67731161-67731241 ( 45) TTCTGCAG 1 chr11:5825361-5825441 ( 46) TTCTGCAG 1 chr22:42500502-42500582 ( 38) TTCTGCAG 1 chr4:152470026-152470106 ( 33) TTCTGCAG 1 chr8:92027836-92027916 ( 34) TTCTGCAG 1 chr7:23693729-23693809 ( 11) TTCTGCAG 1 chr12:31761413-31761493 ( 43) TTCTGCAG 1 chr2:198348420-198348500 ( 38) TTCTGCAG 1 chr16:31860023-31860103 ( 57) TTCTGCAG 1 chr16:72083184-72083264 ( 20) TTCTGCAG 1 chr10:13125850-13125930 ( 53) TTCTGCAG 1 chr22:46967705-46967785 ( 17) TTCTGCAG 1 chr16:87851152-87851232 ( 20) TTCTGCAG 1 chr11:63267511-63267591 ( 30) TTCTGCAG 1 chr10:72525913-72525993 ( 53) TGCTGCAG 1 chr6:170902582-170902662 ( 24) TGCTGCAG 1 chr11:76046199-76046279 ( 58) TGCTGCAG 1 chr5:34782235-34782315 ( 62) TGCTGCAG 1 chr3:152564744-152564824 ( 21) TGCTGCAG 1 chr1:213199196-213199276 ( 65) TGCTGCAG 1 chr1:16429713-16429793 ( 37) TGCTGCAG 1 chr10:35728269-35728349 ( 46) TTCTGCTG 1 chr1:114171745-114171825 ( 70) TTCTGCTG 1 chr8:100697792-100697872 ( 54) TTCTGCTG 1 chr8:99238159-99238239 ( 53) TTCTGCTG 1 chr19:35061216-35061296 ( 30) TCCTGCAG 1 chr18:9503041-9503121 ( 57) TCCTGCAG 1 chr8:56457768-56457848 ( 47) TCCTGCAG 1 chr11:66350128-66350208 ( 63) TCCTGCAG 1 chrX:70546387-70546467 ( 42) TTCTGTAG 1 chr12:9506844-9506924 ( 35) TTCTACAG 1 chr14:21296457-21296537 ( 38) TTCTACAG 1 chr1:9091306-9091386 ( 70) CTCTGCAG 1 chr7:158813707-158813787 ( 49) CTCTGCAG 1 chr12:51306303-51306383 ( 13) TACTGCAG 1 chr8:91789714-91789794 ( 22) TACTGCAG 1 chr17:29965593-29965673 ( 14) CTCTGCAG 1 chr10:71248750-71248830 ( 30) TACTGCAG 1 chr20:62548021-62548101 ( 19) TACTGCAG 1 chr4:72729313-72729393 ( 3) GTCTGCAG 1 chr1:40941133-40941213 ( 66) TTCAGCAG 1 chr7:3821413-3821493 ( 12) TTCAGCAG 1 chr19:46589350-46589430 ( 46) TTCTTCAG 1 chr4:73360048-73360128 ( 61) TTCTTCAG 1 chr11:10894706-10894786 ( 60) TTCTTCAG 1 chr11:2652539-2652619 ( 52) TGCTGCTG 1 chr4:39372999-39373079 ( 28) TGCTGTAG 1 chr3:143277012-143277092 ( 58) TGCTACAG 1 chr19:35040888-35040968 ( 32) TTCTGTTG 1 chr2:10656124-10656204 ( 61) TTCTGTTG 1 chr1:211714321-211714401 ( 60) TTGTGCAG 1 chr1:55399900-55399980 ( 58) TTGTGCAG 1 chr19:47101933-47102013 ( 35) CTCTGCTG 1 chr4:184305540-184305620 ( 36) CTCTGCTG 1 chr7:72802489-72802569 ( 41) TACTGCTG 1 chr8:97667531-97667611 ( 40) GTCTGCTG 1 chr22:21332908-21332988 ( 46) GTCTGCTG 1 chr17:38917018-38917098 ( 37) GTCTGCTG 1 chr9:100166242-100166322 ( 51) TCCTACAG 1 chr2:65271377-65271457 ( 54) TTCTATAG 1 chr1:46859249-46859329 ( 18) TTCTATAG 1 chr11:33953437-33953517 ( 39) TTCTATAG 1 chr11:32390422-32390502 ( 28) CCCTGCAG 1 chr9:91034348-91034428 ( 48) TTCTATAG 1 chr13:21139641-21139721 ( 26) TTCTATAG 1 chr5:126857213-126857293 ( 29) TTCTATAG 1 chr12:131882205-13188228 ( 43) TGCAGCAG 1 chr5:56365088-56365168 ( 64) TTCTATAG 1 chr7:137974777-137974857 ( 39) TTCTATAG 1 chrX:155097640-155097720 ( 34) TTCTATAG 1 chr7:154726146-154726226 ( 45) CCCTGCAG 1 chr16:50475925-50476005 ( 7) TACTGTAG 1 chr6:29661565-29661645 ( 43) TTCAGCTG 1 chr4:128917827-128917907 ( 68) GTCTGTAG 1 chr2:72989585-72989665 ( 18) GACTGCAG 1 chr19:39426066-39426146 ( 4) ATCTGCAG 1 chr5:112190504-112190584 ( 32) TTCTTCTG 1 chr1:154049058-154049138 ( 13) TTCAACAG 1 chr2:109486682-109486762 ( 11) TTCAACAG 1 chr2:70879019-70879099 ( 34) TTCTTCTG 1 chr1:108732994-108733074 ( 12) TACAGCAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 7.97596 E= 9.2e-083 -499 -161 -184 159 -200 -161 -96 139 -1336 227 -342 -1336 -219 -1336 -1336 170 -109 -1336 199 -259 -1336 207 -1336 -101 148 -1336 -1336 -92 -1336 -1336 229 -1336 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 105 E= 9.2e-083 0.009524 0.066667 0.057143 0.866667 0.076190 0.066667 0.104762 0.752381 0.000000 0.980952 0.019048 0.000000 0.066667 0.000000 0.000000 0.933333 0.142857 0.000000 0.809524 0.047619 0.000000 0.857143 0.000000 0.142857 0.847619 0.000000 0.000000 0.152381 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 regular expression -------------------------------------------------------------------------------- TTCTGCAG -------------------------------------------------------------------------------- Time 5.05 secs. ******************************************************************************** ******************************************************************************** MOTIF AGCAAGGC MEME-2 width = 8 sites = 40 llr = 404 E-value = 2.7e-039 ******************************************************************************** -------------------------------------------------------------------------------- Motif AGCAAGGC MEME-2 Description -------------------------------------------------------------------------------- Simplified A a::a8::: pos.-specific C :2a::::a probability G :81:2aa: matrix T ::::::1: bits 2.3 * * 2.1 * *** 1.8 * *** 1.6 **** *** Relative 1.4 **** *** Entropy 1.1 ******** (14.6 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AGCAAGGC consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGCAAGGC MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:45007929-45008009 22 9.93e-06 gaattttctc agcaaggc aactttgctt chr2:65271377-65271457 37 9.93e-06 taattttctc agcaaggc aatttttact chr17:19882127-19882207 44 9.93e-06 aaagatctcc agcaaggc aatctttact chr1:46859249-46859329 3 9.93e-06 tc agcaaggc aatttacttc chr11:33953437-33953517 22 9.93e-06 taattttctc agcaaggc aatttttact chr12:104628847-10462892 24 9.93e-06 agaatttctc agcaaggc aaatttactt chr6:4630173-4630253 27 9.93e-06 aagttttctc agcaaggc aattttactt chr15:93493007-93493087 18 9.93e-06 gaattttctc agcaaggc aattttactt chr19:35408187-35408267 42 9.93e-06 taattttctc agcaaggc catttttatg chr5:150211567-150211647 11 9.93e-06 taattttctc agcaaggc catttttata chr1:244737227-244737307 21 9.93e-06 aaattttctt agcaaggc agttttagtt chr1:147149946-147150026 38 9.93e-06 taattttctc agcaaggc catttttact chr1:30565452-30565532 36 9.93e-06 taattttctc agcaaggc aatttttact chr8:140873373-140873453 21 9.93e-06 taattttctc agcaaggc aatttttact chr2:219216457-219216537 17 9.93e-06 taattttctc agcaaggc aattttactt chr7:72200975-72201055 17 9.93e-06 taattttctc agcaaggc cattttttta chr12:9506844-9506924 20 9.93e-06 aagttttctc agcaaggc aatttacttc chr10:121404663-12140474 36 9.93e-06 aatttttttt agcaaggc aattttactt chr5:56365088-56365168 47 9.93e-06 taattttctc agcaaggc aatttttact chr11:5825361-5825441 31 9.93e-06 aagttatctt agcaaggc aatttacttc chr1:46849497-46849577 9 9.93e-06 ttcttctc agcaaggc aatttacctc chr22:42500502-42500582 23 9.93e-06 aaattttctc agcaaggc aatttacttc chr4:152470026-152470106 15 9.93e-06 taattttctc agcaaggc aacttttact chr8:92027836-92027916 14 9.93e-06 taattttctc agcaaggc catttttata chrX:155097640-155097720 18 9.93e-06 aaattttctc agcaaggc aattttactt chr14:21296457-21296537 22 9.93e-06 tttaattctc agcaaggc aatgtacttt chr11:66350128-66350208 45 9.93e-06 taattttctc agcaaggc catttttact chr5:40877644-40877724 14 9.93e-06 ttttcttctc agcaaggc aatttactcc chr4:128917827-128917907 9 3.32e-05 tgcaggac accagggc atatttcagt chr12:51306303-51306383 24 3.32e-05 actgcaggag accagggc gtatctcagt chr20:55096189-55096269 4 3.32e-05 gag accagggc gtatttcatc chr8:91789714-91789794 33 3.32e-05 actgcaggag accagggc atatctcagc chr6:158718945-158719025 1 3.32e-05 . accagggc gtatctcagt chr6:33120089-33120169 6 3.32e-05 aggag accagggc gtatttcagt chr20:62548021-62548101 30 3.32e-05 actgcaggag accagggc gtatttcagt chr12:22765935-22766015 62 4.31e-05 acctccccca aggaaggc attcctttcc chr6:41182442-41182522 13 6.38e-05 taattttctc agccaggc aatttttact chr1:211714321-211714401 12 6.38e-05 ggcaaggagg agcaagtc acatcttaca chr1:55399900-55399980 12 6.38e-05 ggcaaggagg agcaagtc acgtcttaca chr21:43261129-43261209 71 7.04e-05 aaaataggga aggagggc ta -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGCAAGGC MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:45007929-45008009 9.9e-06 21_[+2]_51 chr2:65271377-65271457 9.9e-06 36_[+2]_36 chr17:19882127-19882207 9.9e-06 43_[+2]_29 chr1:46859249-46859329 9.9e-06 2_[+2]_70 chr11:33953437-33953517 9.9e-06 21_[+2]_51 chr12:104628847-10462892 9.9e-06 23_[+2]_49 chr6:4630173-4630253 9.9e-06 26_[+2]_46 chr15:93493007-93493087 9.9e-06 17_[+2]_55 chr19:35408187-35408267 9.9e-06 41_[+2]_31 chr5:150211567-150211647 9.9e-06 10_[+2]_62 chr1:244737227-244737307 9.9e-06 20_[+2]_52 chr1:147149946-147150026 9.9e-06 37_[+2]_35 chr1:30565452-30565532 9.9e-06 35_[+2]_37 chr8:140873373-140873453 9.9e-06 20_[+2]_52 chr2:219216457-219216537 9.9e-06 16_[+2]_56 chr7:72200975-72201055 9.9e-06 16_[+2]_56 chr12:9506844-9506924 9.9e-06 19_[+2]_53 chr10:121404663-12140474 9.9e-06 35_[+2]_37 chr5:56365088-56365168 9.9e-06 46_[+2]_26 chr11:5825361-5825441 9.9e-06 30_[+2]_42 chr1:46849497-46849577 9.9e-06 8_[+2]_64 chr22:42500502-42500582 9.9e-06 22_[+2]_50 chr4:152470026-152470106 9.9e-06 14_[+2]_58 chr8:92027836-92027916 9.9e-06 13_[+2]_59 chrX:155097640-155097720 9.9e-06 17_[+2]_55 chr14:21296457-21296537 9.9e-06 21_[+2]_51 chr11:66350128-66350208 9.9e-06 44_[+2]_28 chr5:40877644-40877724 9.9e-06 13_[+2]_59 chr4:128917827-128917907 3.3e-05 8_[+2]_64 chr12:51306303-51306383 3.3e-05 23_[+2]_49 chr20:55096189-55096269 3.3e-05 3_[+2]_69 chr8:91789714-91789794 3.3e-05 32_[+2]_40 chr6:158718945-158719025 3.3e-05 [+2]_72 chr6:33120089-33120169 3.3e-05 5_[+2]_67 chr20:62548021-62548101 3.3e-05 29_[+2]_43 chr12:22765935-22766015 4.3e-05 61_[+2]_11 chr6:41182442-41182522 6.4e-05 12_[+2]_60 chr1:211714321-211714401 6.4e-05 11_[+2]_61 chr1:55399900-55399980 6.4e-05 11_[+2]_61 chr21:43261129-43261209 7e-05 70_[+2]_2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGCAAGGC MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AGCAAGGC width=8 seqs=40 chr22:45007929-45008009 ( 22) AGCAAGGC 1 chr2:65271377-65271457 ( 37) AGCAAGGC 1 chr17:19882127-19882207 ( 44) AGCAAGGC 1 chr1:46859249-46859329 ( 3) AGCAAGGC 1 chr11:33953437-33953517 ( 22) AGCAAGGC 1 chr12:104628847-10462892 ( 24) AGCAAGGC 1 chr6:4630173-4630253 ( 27) AGCAAGGC 1 chr15:93493007-93493087 ( 18) AGCAAGGC 1 chr19:35408187-35408267 ( 42) AGCAAGGC 1 chr5:150211567-150211647 ( 11) AGCAAGGC 1 chr1:244737227-244737307 ( 21) AGCAAGGC 1 chr1:147149946-147150026 ( 38) AGCAAGGC 1 chr1:30565452-30565532 ( 36) AGCAAGGC 1 chr8:140873373-140873453 ( 21) AGCAAGGC 1 chr2:219216457-219216537 ( 17) AGCAAGGC 1 chr7:72200975-72201055 ( 17) AGCAAGGC 1 chr12:9506844-9506924 ( 20) AGCAAGGC 1 chr10:121404663-12140474 ( 36) AGCAAGGC 1 chr5:56365088-56365168 ( 47) AGCAAGGC 1 chr11:5825361-5825441 ( 31) AGCAAGGC 1 chr1:46849497-46849577 ( 9) AGCAAGGC 1 chr22:42500502-42500582 ( 23) AGCAAGGC 1 chr4:152470026-152470106 ( 15) AGCAAGGC 1 chr8:92027836-92027916 ( 14) AGCAAGGC 1 chrX:155097640-155097720 ( 18) AGCAAGGC 1 chr14:21296457-21296537 ( 22) AGCAAGGC 1 chr11:66350128-66350208 ( 45) AGCAAGGC 1 chr5:40877644-40877724 ( 14) AGCAAGGC 1 chr4:128917827-128917907 ( 9) ACCAGGGC 1 chr12:51306303-51306383 ( 24) ACCAGGGC 1 chr20:55096189-55096269 ( 4) ACCAGGGC 1 chr8:91789714-91789794 ( 33) ACCAGGGC 1 chr6:158718945-158719025 ( 1) ACCAGGGC 1 chr6:33120089-33120169 ( 6) ACCAGGGC 1 chr20:62548021-62548101 ( 30) ACCAGGGC 1 chr12:22765935-22766015 ( 62) AGGAAGGC 1 chr6:41182442-41182522 ( 13) AGCCAGGC 1 chr1:211714321-211714401 ( 12) AGCAAGTC 1 chr1:55399900-55399980 ( 12) AGCAAGTC 1 chr21:43261129-43261209 ( 71) AGGAGGGC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGCAAGGC MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.08256 E= 2.7e-039 172 -1197 -1197 -1197 -1197 -22 201 -1197 -1197 222 -203 -1197 168 -302 -1197 -1197 139 -1197 -3 -1197 -1197 -1197 229 -1197 -1197 -1197 222 -252 -1197 230 -1197 -1197 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGCAAGGC MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 40 E= 2.7e-039 1.000000 0.000000 0.000000 0.000000 0.000000 0.175000 0.825000 0.000000 0.000000 0.950000 0.050000 0.000000 0.975000 0.025000 0.000000 0.000000 0.800000 0.000000 0.200000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.950000 0.050000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGCAAGGC MEME-2 regular expression -------------------------------------------------------------------------------- AGCA[AG]GGC -------------------------------------------------------------------------------- Time 8.70 secs. ******************************************************************************** ******************************************************************************** MOTIF CCTTGCTG MEME-3 width = 8 sites = 35 llr = 371 E-value = 4.6e-038 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCTTGCTG MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::1:::1: pos.-specific C aa:::a:: probability G ::::9::a matrix T ::9a::9: bits 2.3 ** * 2.1 ** * * 1.8 ** *** * 1.6 ** *** * Relative 1.4 ******** Entropy 1.1 ******** (15.3 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CCTTGCTG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGCTG MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:23698810-23698890 49 8.44e-06 aagtaaatgg ccttgctg agacaacttt chrX:123279756-123279836 47 8.44e-06 aagtaaattg ccttgctg agataattaa chr3:36962813-36962893 56 8.44e-06 gtaaaaattg ccttgctg agaaaattaa chr8:143409873-143409953 62 8.44e-06 agtaaaattg ccttgctg agaaaattat chr3:12906921-12907001 53 8.44e-06 aagtaaattg ccttgctg agagaattaa chr19:15627328-15627408 44 8.44e-06 agtaaaattg ccttgctg agaaaactta chr9:91034348-91034428 66 8.44e-06 aagtaaattg ccttgctg agaagaa chr19:9597848-9597928 67 8.44e-06 agtaaaattg ccttgctg agaaaa chrX:70546387-70546467 62 8.44e-06 agtaaaattg ccttgctg cgaaaacttt chr13:21139641-21139721 44 8.44e-06 aagtaaattg ccttgctg agaaggaaaa chr5:126857213-126857293 48 8.44e-06 agtaaaattg ccttgctg agaaaattaa chr8:144054838-144054918 61 8.44e-06 aagaaaattg ccttgctg agaaaacttt chr12:807556-807636 50 8.44e-06 gtgaaaatgg ccttgctg agaaaattaa chr7:66541274-66541354 48 8.44e-06 aaaaaaatgg ccttgctg agaaaattaa chr8:125924028-125924108 45 8.44e-06 gtaaagattg ccttgctg agaaatcttt chr7:67731161-67731241 66 8.44e-06 gtaaaaattg ccttgctg agaaaat chr7:23693729-23693809 29 8.44e-06 aagtaaattg ccttgctg agacaacttt chr7:137974777-137974857 57 8.44e-06 aagtaaattg ccttgctg agaaaacttt chr12:31761413-31761493 63 8.44e-06 ggtaaaattg ccttgctg agaaaacttt chr2:198348420-198348500 59 8.44e-06 gtaaaaatgg ccttgctg agaaaattaa chr16:72083184-72083264 41 8.44e-06 gtaaaaattg ccttgctg agagaattaa chr10:13125850-13125930 73 8.44e-06 agtaaaataa ccttgctg chr22:46967705-46967785 38 8.44e-06 gtaaaaatgg ccttgctg agataattaa chr16:87851152-87851232 41 8.44e-06 gtaaaaattg ccttgctg agagaattaa chr11:63267511-63267591 53 8.44e-06 ataaaaatgg ccttgctg agaaaattaa chr1:117409253-117409333 49 1.73e-05 tcctgcacca ccatgctg ttatatgggc chr4:72729313-72729393 42 1.73e-05 gccgtgatgc ccatgctg aaggttatgg chr7:138051614-138051694 64 1.73e-05 tcctgcacca ccatgctg ttatatggg chr17:29965593-29965673 53 1.73e-05 gccatgatgc ccatgctg aaggttgtgg chr6:4630173-4630253 62 2.63e-05 aaagggtgct ccttgcag atggaacaat chr8:140873373-140873453 57 2.63e-05 aaagggtgct ccttgcag attaacaatg chr10:121404663-12140474 71 2.63e-05 aaagggtgct ccttgcag at chr14:69268492-69268572 42 3.82e-05 caatcttttt cctttctg ttcctcagac chr10:38407148-38407228 38 6.27e-05 TTAAGTCAGT CCTTACTG TGCATCAGAA chr16:50475925-50476005 35 6.27e-05 cacctcttca ccttgctt actcttcact -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGCTG MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:23698810-23698890 8.4e-06 48_[+3]_24 chrX:123279756-123279836 8.4e-06 46_[+3]_26 chr3:36962813-36962893 8.4e-06 55_[+3]_17 chr8:143409873-143409953 8.4e-06 61_[+3]_11 chr3:12906921-12907001 8.4e-06 52_[+3]_20 chr19:15627328-15627408 8.4e-06 43_[+3]_29 chr9:91034348-91034428 8.4e-06 65_[+3]_7 chr19:9597848-9597928 8.4e-06 66_[+3]_6 chrX:70546387-70546467 8.4e-06 61_[+3]_11 chr13:21139641-21139721 8.4e-06 43_[+3]_29 chr5:126857213-126857293 8.4e-06 47_[+3]_25 chr8:144054838-144054918 8.4e-06 60_[+3]_12 chr12:807556-807636 8.4e-06 49_[+3]_23 chr7:66541274-66541354 8.4e-06 47_[+3]_25 chr8:125924028-125924108 8.4e-06 44_[+3]_28 chr7:67731161-67731241 8.4e-06 65_[+3]_7 chr7:23693729-23693809 8.4e-06 28_[+3]_44 chr7:137974777-137974857 8.4e-06 56_[+3]_16 chr12:31761413-31761493 8.4e-06 62_[+3]_10 chr2:198348420-198348500 8.4e-06 58_[+3]_14 chr16:72083184-72083264 8.4e-06 40_[+3]_32 chr10:13125850-13125930 8.4e-06 72_[+3] chr22:46967705-46967785 8.4e-06 37_[+3]_35 chr16:87851152-87851232 8.4e-06 40_[+3]_32 chr11:63267511-63267591 8.4e-06 52_[+3]_20 chr1:117409253-117409333 1.7e-05 48_[+3]_24 chr4:72729313-72729393 1.7e-05 41_[+3]_31 chr7:138051614-138051694 1.7e-05 63_[+3]_9 chr17:29965593-29965673 1.7e-05 52_[+3]_20 chr6:4630173-4630253 2.6e-05 61_[+3]_11 chr8:140873373-140873453 2.6e-05 56_[+3]_16 chr10:121404663-12140474 2.6e-05 70_[+3]_2 chr14:69268492-69268572 3.8e-05 41_[+3]_31 chr10:38407148-38407228 6.3e-05 37_[+3]_35 chr16:50475925-50476005 6.3e-05 34_[+3]_38 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGCTG MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCTTGCTG width=8 seqs=35 chr7:23698810-23698890 ( 49) CCTTGCTG 1 chrX:123279756-123279836 ( 47) CCTTGCTG 1 chr3:36962813-36962893 ( 56) CCTTGCTG 1 chr8:143409873-143409953 ( 62) CCTTGCTG 1 chr3:12906921-12907001 ( 53) CCTTGCTG 1 chr19:15627328-15627408 ( 44) CCTTGCTG 1 chr9:91034348-91034428 ( 66) CCTTGCTG 1 chr19:9597848-9597928 ( 67) CCTTGCTG 1 chrX:70546387-70546467 ( 62) CCTTGCTG 1 chr13:21139641-21139721 ( 44) CCTTGCTG 1 chr5:126857213-126857293 ( 48) CCTTGCTG 1 chr8:144054838-144054918 ( 61) CCTTGCTG 1 chr12:807556-807636 ( 50) CCTTGCTG 1 chr7:66541274-66541354 ( 48) CCTTGCTG 1 chr8:125924028-125924108 ( 45) CCTTGCTG 1 chr7:67731161-67731241 ( 66) CCTTGCTG 1 chr7:23693729-23693809 ( 29) CCTTGCTG 1 chr7:137974777-137974857 ( 57) CCTTGCTG 1 chr12:31761413-31761493 ( 63) CCTTGCTG 1 chr2:198348420-198348500 ( 59) CCTTGCTG 1 chr16:72083184-72083264 ( 41) CCTTGCTG 1 chr10:13125850-13125930 ( 73) CCTTGCTG 1 chr22:46967705-46967785 ( 38) CCTTGCTG 1 chr16:87851152-87851232 ( 41) CCTTGCTG 1 chr11:63267511-63267591 ( 53) CCTTGCTG 1 chr1:117409253-117409333 ( 49) CCATGCTG 1 chr4:72729313-72729393 ( 42) CCATGCTG 1 chr7:138051614-138051694 ( 64) CCATGCTG 1 chr17:29965593-29965673 ( 53) CCATGCTG 1 chr6:4630173-4630253 ( 62) CCTTGCAG 1 chr8:140873373-140873453 ( 57) CCTTGCAG 1 chr10:121404663-12140474 ( 71) CCTTGCAG 1 chr14:69268492-69268572 ( 42) CCTTTCTG 1 chr10:38407148-38407228 ( 38) CCTTACTG 1 chr16:50475925-50476005 ( 35) CCTTGCTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGCTG MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.12623 E= 4.6e-038 -1177 230 -1177 -1177 -1177 230 -1177 -1177 -141 -1177 -1177 162 -1177 -1177 -1177 180 -341 -1177 220 -333 -1177 230 -1177 -1177 -183 -1177 -1177 167 -1177 -1177 225 -333 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGCTG MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 35 E= 4.6e-038 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.114286 0.000000 0.000000 0.885714 0.000000 0.000000 0.000000 1.000000 0.028571 0.000000 0.942857 0.028571 0.000000 1.000000 0.000000 0.000000 0.085714 0.000000 0.000000 0.914286 0.000000 0.000000 0.971429 0.028571 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGCTG MEME-3 regular expression -------------------------------------------------------------------------------- CCTTGCTG -------------------------------------------------------------------------------- Time 12.27 secs. ******************************************************************************** ******************************************************************************** MOTIF AAGGGTGC MEME-4 width = 8 sites = 27 llr = 282 E-value = 1.4e-021 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 Description -------------------------------------------------------------------------------- Simplified A aa::::2: pos.-specific C :::::::9 probability G ::aaa:8: matrix T :::::a:1 bits 2.3 ** 2.1 *** 1.8 **** * 1.6 ****** * Relative 1.4 ******** Entropy 1.1 ******** (15.1 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AAGGGTGC consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:45007929-45008009 48 9.40e-06 tttctgcaga aagggtgc tcctcacaga chr17:19882127-19882207 71 9.40e-06 tttctgcaga aagggtgc tc chr1:46859249-46859329 26 9.40e-06 acttctatag aagggtgc gccctcacag chr11:33953437-33953517 47 9.40e-06 acttctatag aagggtgc gactcacgga chr6:4630173-4630253 53 9.40e-06 tttctgcaga aagggtgc tccttgcaga chr15:93493007-93493087 44 9.40e-06 tttctgcaga aagggtgc ttcttggaag chr6:41182442-41182522 40 9.40e-06 tttctgcaga aagggtgc ttctcacaga chr1:244737227-244737307 47 9.40e-06 tttctgcaga aagggtgc tcctcacaga chr1:30565452-30565532 63 9.40e-06 tttctgcaga aagggtgc tcttcacaga chr8:140873373-140873453 48 9.40e-06 tttctgcaga aagggtgc tccttgcaga chr12:9506844-9506924 43 9.40e-06 acttctacag aagggtgc atctcacgga chr10:121404663-12140474 62 9.40e-06 tttctgcaga aagggtgc tccttgcaga chr5:56365088-56365168 72 9.40e-06 acttctatag aagggtgc g chr11:5825361-5825441 54 9.40e-06 acttctgcag aagggtgc cactcacatc chr22:42500502-42500582 46 9.40e-06 acttctgcag aagggtgc tgcttgtgtc chr4:152470026-152470106 42 9.40e-06 tttctgcaga aagggtgc ccctcgcaga chr14:21296457-21296537 46 9.40e-06 ctttctacag aagggtgc acccttacag chr5:40877644-40877724 37 9.40e-06 actcctatag aagggtgc accctcacag chr19:35408187-35408267 71 2.34e-05 tttctgcaga aagggtac ac chr5:150211567-150211647 40 2.34e-05 tttctgcaga aagggtac actcgccagc chr1:147149946-147150026 65 2.34e-05 tttctgcaga aagggtac actcacca chr7:72200975-72201055 46 2.34e-05 tttctgcaga aagggtac actcgccagc chr8:92027836-92027916 43 2.34e-05 tttctgcaga aagggtac actcgccagc chr2:219216457-219216537 41 3.67e-05 acttccatac aagggtgt gtctcacgga chr1:46849497-46849577 32 3.67e-05 acctctatag aagggtgt gccctcacag chrX:155097640-155097720 42 3.67e-05 acttctatag aagggtgt gtctcacaga chr12:104628847-10462892 48 5.07e-05 acttctgcag aaaggtgc tgctcattct -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:45007929-45008009 9.4e-06 47_[+4]_25 chr17:19882127-19882207 9.4e-06 70_[+4]_2 chr1:46859249-46859329 9.4e-06 25_[+4]_47 chr11:33953437-33953517 9.4e-06 46_[+4]_26 chr6:4630173-4630253 9.4e-06 52_[+4]_20 chr15:93493007-93493087 9.4e-06 43_[+4]_29 chr6:41182442-41182522 9.4e-06 39_[+4]_33 chr1:244737227-244737307 9.4e-06 46_[+4]_26 chr1:30565452-30565532 9.4e-06 62_[+4]_10 chr8:140873373-140873453 9.4e-06 47_[+4]_25 chr12:9506844-9506924 9.4e-06 42_[+4]_30 chr10:121404663-12140474 9.4e-06 61_[+4]_11 chr5:56365088-56365168 9.4e-06 71_[+4]_1 chr11:5825361-5825441 9.4e-06 53_[+4]_19 chr22:42500502-42500582 9.4e-06 45_[+4]_27 chr4:152470026-152470106 9.4e-06 41_[+4]_31 chr14:21296457-21296537 9.4e-06 45_[+4]_27 chr5:40877644-40877724 9.4e-06 36_[+4]_36 chr19:35408187-35408267 2.3e-05 70_[+4]_2 chr5:150211567-150211647 2.3e-05 39_[+4]_33 chr1:147149946-147150026 2.3e-05 64_[+4]_8 chr7:72200975-72201055 2.3e-05 45_[+4]_27 chr8:92027836-92027916 2.3e-05 42_[+4]_30 chr2:219216457-219216537 3.7e-05 40_[+4]_32 chr1:46849497-46849577 3.7e-05 31_[+4]_41 chrX:155097640-155097720 3.7e-05 41_[+4]_31 chr12:104628847-10462892 5.1e-05 47_[+4]_25 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAGGGTGC width=8 seqs=27 chr22:45007929-45008009 ( 48) AAGGGTGC 1 chr17:19882127-19882207 ( 71) AAGGGTGC 1 chr1:46859249-46859329 ( 26) AAGGGTGC 1 chr11:33953437-33953517 ( 47) AAGGGTGC 1 chr6:4630173-4630253 ( 53) AAGGGTGC 1 chr15:93493007-93493087 ( 44) AAGGGTGC 1 chr6:41182442-41182522 ( 40) AAGGGTGC 1 chr1:244737227-244737307 ( 47) AAGGGTGC 1 chr1:30565452-30565532 ( 63) AAGGGTGC 1 chr8:140873373-140873453 ( 48) AAGGGTGC 1 chr12:9506844-9506924 ( 43) AAGGGTGC 1 chr10:121404663-12140474 ( 62) AAGGGTGC 1 chr5:56365088-56365168 ( 72) AAGGGTGC 1 chr11:5825361-5825441 ( 54) AAGGGTGC 1 chr22:42500502-42500582 ( 46) AAGGGTGC 1 chr4:152470026-152470106 ( 42) AAGGGTGC 1 chr14:21296457-21296537 ( 46) AAGGGTGC 1 chr5:40877644-40877724 ( 37) AAGGGTGC 1 chr19:35408187-35408267 ( 71) AAGGGTAC 1 chr5:150211567-150211647 ( 40) AAGGGTAC 1 chr1:147149946-147150026 ( 65) AAGGGTAC 1 chr7:72200975-72201055 ( 46) AAGGGTAC 1 chr8:92027836-92027916 ( 43) AAGGGTAC 1 chr2:219216457-219216537 ( 41) AAGGGTGT 1 chr1:46849497-46849577 ( 32) AAGGGTGT 1 chrX:155097640-155097720 ( 42) AAGGGTGT 1 chr12:104628847-10462892 ( 48) AAAGGTGC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.9683 E= 1.4e-021 172 -1140 -1140 -1140 172 -1140 -1140 -1140 -304 -1140 224 -1140 -1140 -1140 229 -1140 -1140 -1140 229 -1140 -1140 -1140 -1140 180 -72 -1140 199 -1140 -1140 213 -1140 -137 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 27 E= 1.4e-021 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.037037 0.000000 0.962963 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.185185 0.000000 0.814815 0.000000 0.000000 0.888889 0.000000 0.111111 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 regular expression -------------------------------------------------------------------------------- AAGGGTGC -------------------------------------------------------------------------------- Time 15.75 secs. ******************************************************************************** ******************************************************************************** MOTIF ATTTTCTC MEME-5 width = 8 sites = 64 llr = 487 E-value = 3.4e-014 ******************************************************************************** -------------------------------------------------------------------------------- Motif ATTTTCTC MEME-5 Description -------------------------------------------------------------------------------- Simplified A 6::2:::: pos.-specific C 2::2:7:a probability G :::1:::: matrix T 2aa5a3a: bits 2.3 2.1 * 1.8 ** * ** 1.6 ** * ** Relative 1.4 ** * ** Entropy 1.1 ** **** (11.0 bits) 0.9 ** **** 0.7 ** **** 0.5 ** **** 0.2 ******** 0.0 -------- Multilevel ATTTTCTC consensus T A T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTTTCTC MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:45007929-45008009 14 2.51e-05 cagacaaaga attttctc agcaaggcaa chr2:65271377-65271457 29 2.51e-05 cataaattta attttctc agcaaggcaa chr11:33953437-33953517 14 2.51e-05 cataaattta attttctc agcaaggcaa chr15:93493007-93493087 10 2.51e-05 gctcaagga attttctc agcaaggcaa chr19:35408187-35408267 34 2.51e-05 cgtaaattta attttctc agcaaggcca chr5:150211567-150211647 3 2.51e-05 ta attttctc agcaaggcca chr6:41182442-41182522 5 2.51e-05 ttta attttctc agccaggcaa chr1:147149946-147150026 30 2.51e-05 cataaattta attttctc agcaaggcca chr1:30565452-30565532 28 2.51e-05 cataaattta attttctc agcaaggcaa chr8:140873373-140873453 13 2.51e-05 cataaatgta attttctc agcaaggcaa chr2:219216457-219216537 9 2.51e-05 taaattta attttctc agcaaggcaa chr7:72200975-72201055 9 2.51e-05 taaattta attttctc agcaaggcca chr5:90539214-90539294 68 2.51e-05 tgtatatcat attttctc actgt chr5:56365088-56365168 39 2.51e-05 gataaattta attttctc agcaaggcaa chr22:42500502-42500582 15 2.51e-05 tcaggcaaaa attttctc agcaaggcaa chr4:152470026-152470106 7 2.51e-05 aattta attttctc agcaaggcaa chr8:92027836-92027916 6 2.51e-05 attta attttctc agcaaggcca chrX:155097640-155097720 10 2.51e-05 caaacataa attttctc agcaaggcaa chr11:66350128-66350208 37 2.51e-05 cataaattta attttctc agcaaggcca chr1:33530006-33530086 11 5.96e-05 gtgtctcttt cttttctc agtctcttgt chr10:52111372-52111452 48 1.10e-04 ttgctcctca tttttctc ttgccgccac chr3:142892249-142892329 9 1.10e-04 ttctatct tttttctc tgtgcttcat chr5:81543133-81543213 16 1.10e-04 tcttcaattt tttttctc ttttcttcac chr1:108732994-108733074 39 1.63e-04 agctttgtgt attgtctc tagagatagc chr1:172589924-172590004 13 1.93e-04 tatttcatcc cttatctc aaccacataa chr4:128917827-128917907 28 1.93e-04 tatttcagtc cttatctc aactgcataa chr12:51306303-51306383 43 1.93e-04 tatctcagtc cttatctc aactgcataa chr3:197694619-197694699 15 1.93e-04 tatttcagtc cttatctc aaccacataa chr8:91789714-91789794 52 1.93e-04 tatctcagcc cttatctc aaccgcataa chr6:158718945-158719025 20 1.93e-04 tatctcagtc cttatctc aaccgcataa chr10:71248750-71248830 60 1.93e-04 tatttcagtc cttatctc aactgcataa chr6:33120089-33120169 25 1.93e-04 tatttcagtc cttatctc aaccgcataa chr12:22765935-22766015 4 1.93e-04 gtc cttatctc aactacacaa chr20:62548021-62548101 49 1.93e-04 tatttcagtc cttatctc aaccacataa chr19:9524020-9524100 27 2.09e-04 ATTCATAGGG TTTCTCTC CAGTGTGAGT chr19:12244051-12244131 23 2.09e-04 ATTCATAGGG TTTCTCTC CAGTGTGAGT chr10:35728269-35728349 33 2.83e-04 cagttcactg attctttc ttctgttctg chr15:70217020-70217100 63 2.83e-04 tttccatgtc tttatctc tctgcatgct chr19:35040888-35040968 10 2.83e-04 cactcacag attctttc cttgatcttc chr1:118313874-118313954 39 2.83e-04 taaggtactg attctttc ttttgcatga chr3:172718531-172718611 46 2.83e-04 aagctcagag attctttc tttggtcatg chr17:38917018-38917098 15 2.83e-04 gagtttgcta attctttc ttctgcatga chr8:100697792-100697872 32 2.83e-04 aaactcacta attctttc ttcagcttga chr21:39470055-39470135 44 2.83e-04 aagctcactg attctttc tttggctgtg chr2:98502410-98502490 15 2.83e-04 tttcttcacc cttttttc tttttttgtc chr8:99238159-99238239 31 2.83e-04 aagctcgcta attctttc ttctgcttga chr6:29661565-29661645 5 2.83e-04 tgaa attctttc ttctgcttgg chr2:131712588-131712668 20 3.21e-04 aagtttgcta attatttc ttccatctat chr14:69268492-69268572 63 3.21e-04 ctcagacttg attatttc cagtgtccta chr1:114171745-114171825 48 3.21e-04 aagctcacta attatttc ttctacttga chr1:20344392-20344472 31 3.54e-04 agtttacaga tttttttc tgcttgtgtc chr1:228431758-228431838 43 3.54e-04 cttcatggca tttttttc tttgatgaac chr1:228432886-228432966 32 3.54e-04 tttcatggca tttttttc tttgatgaac chr5:40877644-40877724 1 3.54e-04 . tttttttc ttctcagcaa chr19:35041089-35041169 64 3.83e-04 tgatagctgc tttgtctc ttcataatg chr8:125924028-125924108 61 3.83e-04 tgagaaatct tttgtctc catgctgact chr19:47101933-47102013 13 4.08e-04 aagttcactg attgtttc ctctgcttga chr7:72802489-72802569 16 4.08e-04 aagtttacta attgtttc ttctgccagt chr1:211346032-211346112 15 4.08e-04 tcttattttc attgtttc caatgaaaaa chr6:4630173-4630253 19 4.42e-04 tagacaaaaa gttttctc agcaaggcaa chr12:9506844-9506924 12 4.42e-04 tcaggcaaaa gttttctc agcaaggcaa chr11:77556375-77556455 55 5.26e-04 tagtgacatt tttatttc catcattgta chr5:180198976-180199056 22 6.67e-04 gttagcagtt attttctt tcagtacttt chr1:244737227-244737307 13 6.67e-04 tagacaaaaa attttctt agcaaggcag -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTTTCTC MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:45007929-45008009 2.5e-05 13_[+5]_59 chr2:65271377-65271457 2.5e-05 28_[+5]_44 chr11:33953437-33953517 2.5e-05 13_[+5]_59 chr15:93493007-93493087 2.5e-05 9_[+5]_63 chr19:35408187-35408267 2.5e-05 33_[+5]_39 chr5:150211567-150211647 2.5e-05 2_[+5]_70 chr6:41182442-41182522 2.5e-05 4_[+5]_68 chr1:147149946-147150026 2.5e-05 29_[+5]_43 chr1:30565452-30565532 2.5e-05 27_[+5]_45 chr8:140873373-140873453 2.5e-05 12_[+5]_60 chr2:219216457-219216537 2.5e-05 8_[+5]_64 chr7:72200975-72201055 2.5e-05 8_[+5]_64 chr5:90539214-90539294 2.5e-05 67_[+5]_5 chr5:56365088-56365168 2.5e-05 38_[+5]_34 chr22:42500502-42500582 2.5e-05 14_[+5]_58 chr4:152470026-152470106 2.5e-05 6_[+5]_66 chr8:92027836-92027916 2.5e-05 5_[+5]_67 chrX:155097640-155097720 2.5e-05 9_[+5]_63 chr11:66350128-66350208 2.5e-05 36_[+5]_36 chr1:33530006-33530086 6e-05 10_[+5]_62 chr10:52111372-52111452 0.00011 47_[+5]_25 chr3:142892249-142892329 0.00011 8_[+5]_64 chr5:81543133-81543213 0.00011 15_[+5]_57 chr1:108732994-108733074 0.00016 38_[+5]_34 chr1:172589924-172590004 0.00019 12_[+5]_60 chr4:128917827-128917907 0.00019 27_[+5]_45 chr12:51306303-51306383 0.00019 42_[+5]_30 chr3:197694619-197694699 0.00019 14_[+5]_58 chr8:91789714-91789794 0.00019 51_[+5]_21 chr6:158718945-158719025 0.00019 19_[+5]_53 chr10:71248750-71248830 0.00019 59_[+5]_13 chr6:33120089-33120169 0.00019 24_[+5]_48 chr12:22765935-22766015 0.00019 3_[+5]_69 chr20:62548021-62548101 0.00019 48_[+5]_24 chr19:9524020-9524100 0.00021 26_[+5]_46 chr19:12244051-12244131 0.00021 22_[+5]_50 chr10:35728269-35728349 0.00028 32_[+5]_40 chr15:70217020-70217100 0.00028 62_[+5]_10 chr19:35040888-35040968 0.00028 9_[+5]_63 chr1:118313874-118313954 0.00028 38_[+5]_34 chr3:172718531-172718611 0.00028 45_[+5]_27 chr17:38917018-38917098 0.00028 14_[+5]_58 chr8:100697792-100697872 0.00028 31_[+5]_41 chr21:39470055-39470135 0.00028 43_[+5]_29 chr2:98502410-98502490 0.00028 14_[+5]_58 chr8:99238159-99238239 0.00028 30_[+5]_42 chr6:29661565-29661645 0.00028 4_[+5]_68 chr2:131712588-131712668 0.00032 19_[+5]_53 chr14:69268492-69268572 0.00032 62_[+5]_10 chr1:114171745-114171825 0.00032 47_[+5]_25 chr1:20344392-20344472 0.00035 30_[+5]_42 chr1:228431758-228431838 0.00035 42_[+5]_30 chr1:228432886-228432966 0.00035 31_[+5]_41 chr5:40877644-40877724 0.00035 [+5]_72 chr19:35041089-35041169 0.00038 63_[+5]_9 chr8:125924028-125924108 0.00038 60_[+5]_12 chr19:47101933-47102013 0.00041 12_[+5]_60 chr7:72802489-72802569 0.00041 15_[+5]_57 chr1:211346032-211346112 0.00041 14_[+5]_58 chr6:4630173-4630253 0.00044 18_[+5]_54 chr12:9506844-9506924 0.00044 11_[+5]_61 chr11:77556375-77556455 0.00053 54_[+5]_18 chr5:180198976-180199056 0.00067 21_[+5]_51 chr1:244737227-244737307 0.00067 12_[+5]_60 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTTTCTC MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ATTTTCTC width=8 seqs=64 chr22:45007929-45008009 ( 14) ATTTTCTC 1 chr2:65271377-65271457 ( 29) ATTTTCTC 1 chr11:33953437-33953517 ( 14) ATTTTCTC 1 chr15:93493007-93493087 ( 10) ATTTTCTC 1 chr19:35408187-35408267 ( 34) ATTTTCTC 1 chr5:150211567-150211647 ( 3) ATTTTCTC 1 chr6:41182442-41182522 ( 5) ATTTTCTC 1 chr1:147149946-147150026 ( 30) ATTTTCTC 1 chr1:30565452-30565532 ( 28) ATTTTCTC 1 chr8:140873373-140873453 ( 13) ATTTTCTC 1 chr2:219216457-219216537 ( 9) ATTTTCTC 1 chr7:72200975-72201055 ( 9) ATTTTCTC 1 chr5:90539214-90539294 ( 68) ATTTTCTC 1 chr5:56365088-56365168 ( 39) ATTTTCTC 1 chr22:42500502-42500582 ( 15) ATTTTCTC 1 chr4:152470026-152470106 ( 7) ATTTTCTC 1 chr8:92027836-92027916 ( 6) ATTTTCTC 1 chrX:155097640-155097720 ( 10) ATTTTCTC 1 chr11:66350128-66350208 ( 37) ATTTTCTC 1 chr1:33530006-33530086 ( 11) CTTTTCTC 1 chr10:52111372-52111452 ( 48) TTTTTCTC 1 chr3:142892249-142892329 ( 9) TTTTTCTC 1 chr5:81543133-81543213 ( 16) TTTTTCTC 1 chr1:108732994-108733074 ( 39) ATTGTCTC 1 chr1:172589924-172590004 ( 13) CTTATCTC 1 chr4:128917827-128917907 ( 28) CTTATCTC 1 chr12:51306303-51306383 ( 43) CTTATCTC 1 chr3:197694619-197694699 ( 15) CTTATCTC 1 chr8:91789714-91789794 ( 52) CTTATCTC 1 chr6:158718945-158719025 ( 20) CTTATCTC 1 chr10:71248750-71248830 ( 60) CTTATCTC 1 chr6:33120089-33120169 ( 25) CTTATCTC 1 chr12:22765935-22766015 ( 4) CTTATCTC 1 chr20:62548021-62548101 ( 49) CTTATCTC 1 chr19:9524020-9524100 ( 27) TTTCTCTC 1 chr19:12244051-12244131 ( 23) TTTCTCTC 1 chr10:35728269-35728349 ( 33) ATTCTTTC 1 chr15:70217020-70217100 ( 63) TTTATCTC 1 chr19:35040888-35040968 ( 10) ATTCTTTC 1 chr1:118313874-118313954 ( 39) ATTCTTTC 1 chr3:172718531-172718611 ( 46) ATTCTTTC 1 chr17:38917018-38917098 ( 15) ATTCTTTC 1 chr8:100697792-100697872 ( 32) ATTCTTTC 1 chr21:39470055-39470135 ( 44) ATTCTTTC 1 chr2:98502410-98502490 ( 15) CTTTTTTC 1 chr8:99238159-99238239 ( 31) ATTCTTTC 1 chr6:29661565-29661645 ( 5) ATTCTTTC 1 chr2:131712588-131712668 ( 20) ATTATTTC 1 chr14:69268492-69268572 ( 63) ATTATTTC 1 chr1:114171745-114171825 ( 48) ATTATTTC 1 chr1:20344392-20344472 ( 31) TTTTTTTC 1 chr1:228431758-228431838 ( 43) TTTTTTTC 1 chr1:228432886-228432966 ( 32) TTTTTTTC 1 chr5:40877644-40877724 ( 1) TTTTTTTC 1 chr19:35041089-35041169 ( 64) TTTGTCTC 1 chr8:125924028-125924108 ( 61) TTTGTCTC 1 chr19:47101933-47102013 ( 13) ATTGTTTC 1 chr7:72802489-72802569 ( 16) ATTGTTTC 1 chr1:211346032-211346112 ( 15) ATTGTTTC 1 chr6:4630173-4630253 ( 19) GTTTTCTC 1 chr12:9506844-9506924 ( 12) GTTTTCTC 1 chr11:77556375-77556455 ( 55) TTTATTTC 1 chr5:180198976-180199056 ( 22) ATTTTCTT 1 chr1:244737227-244737307 ( 13) ATTTTCTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTTTCTC MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.47551 E= 3.4e-014 92 -12 -271 -50 -1264 -1264 -1264 180 -1264 -1264 -1264 180 -38 -24 -112 80 -1264 -1264 -1264 180 -1264 172 -1264 19 -1264 -1264 -1264 180 -1264 225 -1264 -320 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTTTCTC MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 64 E= 3.4e-014 0.578125 0.187500 0.031250 0.203125 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.234375 0.171875 0.093750 0.500000 0.000000 0.000000 0.000000 1.000000 0.000000 0.671875 0.000000 0.328125 0.000000 0.000000 0.000000 1.000000 0.000000 0.968750 0.000000 0.031250 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTTTCTC MEME-5 regular expression -------------------------------------------------------------------------------- [AT]TT[TA]T[CT]TC -------------------------------------------------------------------------------- Time 19.24 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr11:63267511-63267591 7.56e-05 29_[+1(1.26e-05)]_15_[+3(8.44e-06)]_\ 20 chr16:87851152-87851232 2.91e-04 19_[+1(1.26e-05)]_13_[+3(8.44e-06)]_\ 32 chr22:46967705-46967785 5.67e-04 16_[+1(1.26e-05)]_13_[+3(8.44e-06)]_\ 35 chr10:13125850-13125930 1.06e-04 52_[+1(1.26e-05)]_12_[+3(8.44e-06)] chr5:81543133-81543213 1.55e-01 80 chr5:40877644-40877724 2.13e-06 13_[+2(9.93e-06)]_15_[+4(9.40e-06)]_\ 36 chr11:12510983-12511063 8.07e-01 80 chr21:43261129-43261209 9.84e-02 70_[+2(7.04e-05)]_2 chr11:66350128-66350208 1.45e-07 36_[+5(2.51e-05)]_[+2(9.93e-06)]_10_\ [+1(4.23e-05)]_1_[+4(7.05e-05)]_1 chr15:51777121-51777201 8.61e-01 80 chr16:72083184-72083264 2.52e-04 19_[+1(1.26e-05)]_13_[+3(8.44e-06)]_\ 32 chr16:31860023-31860103 4.53e-04 56_[+1(1.26e-05)]_16 chr7:44564574-44564654 3.47e-01 80 chr22:20728597-20728677 7.59e-01 80 chr12:62857176-62857256 6.95e-01 80 chr6:29661565-29661645 4.31e-02 80 chr8:99238159-99238239 4.77e-03 52_[+1(3.34e-05)]_20 chr4:38714474-38714554 2.87e-01 80 chr1:16429713-16429793 3.50e-02 36_[+1(2.15e-05)]_36 chr20:57061466-57061546 7.96e-01 80 chr7:154726146-154726226 2.42e-02 80 chr15:102163817-10216389 8.93e-01 80 chr14:21296457-21296537 5.02e-08 21_[+2(9.93e-06)]_8_[+1(7.88e-05)]_\ [+4(9.40e-06)]_27 chrX:155097640-155097720 1.07e-06 9_[+5(2.51e-05)]_[+2(9.93e-06)]_16_\ [+4(3.67e-05)]_31 chr9:100166242-100166322 4.93e-02 80 chr4:89041220-89041300 5.27e-02 80 chr20:62548021-62548101 4.39e-05 29_[+2(3.32e-05)]_43 chr10:22295479-22295559 6.38e-01 80 chr2:198348420-198348500 2.63e-04 37_[+1(1.26e-05)]_13_[+3(8.44e-06)]_\ 14 chr7:102904658-102904738 5.87e-02 80 chr7:29946027-29946107 3.99e-01 80 chr1:213199196-213199276 9.21e-03 64_[+1(2.15e-05)]_8 chr6:49816974-49817054 2.52e-01 80 chr2:109323950-109324030 9.97e-01 80 chr1:228432886-228432966 2.50e-01 80 chr15:96244774-96244854 3.41e-01 80 chr12:31761413-31761493 3.45e-04 42_[+1(1.26e-05)]_12_[+3(8.44e-06)]_\ 10 chr19:758920-759000 3.18e-01 80 chr3:152564744-152564824 3.02e-03 20_[+1(2.15e-05)]_52 chr17:55326895-55326975 8.79e-01 80 chr2:98502410-98502490 1.99e-01 80 chr5:34782235-34782315 3.03e-02 61_[+1(2.15e-05)]_11 chr2:86498513-86498593 6.86e-01 80 chr12:22765935-22766015 7.54e-03 61_[+2(4.31e-05)]_11 chr3:142892249-142892329 3.16e-02 80 chr9:135971655-135971735 3.64e-02 80 chr7:137974777-137974857 1.01e-02 56_[+3(8.44e-06)]_16 chr7:23693729-23693809 2.68e-04 10_[+1(1.26e-05)]_10_[+3(8.44e-06)]_\ 44 chr11:77556375-77556455 1.61e-01 80 chr8:92027836-92027916 6.33e-09 5_[+5(2.51e-05)]_[+2(9.93e-06)]_12_\ [+1(1.26e-05)]_1_[+4(2.34e-05)]_30 chr8:100768413-100768493 7.04e-01 80 chr6:33120089-33120169 9.02e-03 5_[+2(3.32e-05)]_67 chr4:152470026-152470106 1.73e-09 6_[+5(2.51e-05)]_[+2(9.93e-06)]_10_\ [+1(1.26e-05)]_1_[+4(9.40e-06)]_31 chr22:42500502-42500582 2.20e-08 14_[+5(2.51e-05)]_[+2(9.93e-06)]_7_\ [+1(1.26e-05)]_[+4(9.40e-06)]_27 chr1:228431758-228431838 2.44e-01 80 chr1:55399900-55399980 7.49e-03 11_[+2(6.38e-05)]_61 chr17:27361693-27361773 7.45e-01 80 chr5:53252626-53252706 9.43e-01 80 chr2:26303953-26304033 5.56e-01 80 chr17:35704105-35704185 4.05e-01 80 chr16:50475925-50476005 2.32e-02 34_[+3(6.27e-05)]_38 chr2:99887518-99887598 5.14e-01 80 chr21:39470055-39470135 2.77e-01 80 chr2:70879019-70879099 8.52e-02 80 chr1:46849497-46849577 3.97e-05 8_[+2(9.93e-06)]_15_[+4(3.67e-05)]_\ 41 chr4:1176287-1176367 8.47e-01 80 chr10:71248750-71248830 3.54e-04 80 chr13:21344165-21344245 5.76e-01 80 chr11:76046199-76046279 1.31e-02 57_[+1(2.15e-05)]_15 chr1:211714321-211714401 2.03e-02 11_[+2(6.38e-05)]_61 chr7:72311881-72311961 2.29e-01 80 chr8:100697792-100697872 5.79e-03 53_[+1(3.34e-05)]_19 chr1:26270029-26270109 3.28e-01 80 chr11:5825361-5825441 6.97e-07 30_[+2(9.93e-06)]_7_[+1(1.26e-05)]_\ [+4(9.40e-06)]_19 chr17:29965593-29965673 7.48e-04 52_[+3(1.73e-05)]_20 chr7:67731161-67731241 1.69e-04 44_[+1(1.26e-05)]_13_[+3(8.44e-06)]_\ 7 chr1:184963575-184963655 1.80e-01 80 chr12:51259163-51259243 6.11e-01 80 chr3:136372615-136372695 4.51e-01 80 chr5:56365088-56365168 3.64e-07 38_[+5(2.51e-05)]_[+2(9.93e-06)]_17_\ [+4(9.40e-06)]_1 chr1:114171745-114171825 2.01e-03 69_[+1(3.34e-05)]_3 chr10:22224521-22224601 9.94e-01 80 chr8:125924028-125924108 2.26e-05 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