******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/ZBTB33.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr7:100231579-100231659 1.0000 80 chr12:133387244-13338732 1.0000 80 chr3:46965132-46965212 1.0000 80 chr19:10939779-10939859 1.0000 80 chr6:15512601-15512681 1.0000 80 chr1:25828385-25828465 1.0000 80 chr20:34274950-34275030 1.0000 80 chr20:62427636-62427716 1.0000 80 chr9:132630169-132630249 1.0000 80 chr11:68657738-68657818 1.0000 80 chr5:1599285-1599365 1.0000 80 chr14:21558586-21558666 1.0000 80 chr16:4311731-4311811 1.0000 80 chr20:62245737-62245817 1.0000 80 chr11:57080018-57080098 1.0000 80 chr19:32868131-32868211 1.0000 80 chr5:115422171-115422251 1.0000 80 chr7:2139990-2140070 1.0000 80 chr9:131641707-131641787 1.0000 80 chr6:14397571-14397651 1.0000 80 chr5:156751382-156751462 1.0000 80 chr14:103763416-10376349 1.0000 80 chr4:1914947-1915027 1.0000 80 chr1:38494916-38494996 1.0000 80 chr12:49677970-49678050 1.0000 80 chr9:139870181-139870261 1.0000 80 chr6:44195308-44195388 1.0000 80 chr22:21062153-21062233 1.0000 80 chr12:123942292-12394237 1.0000 80 chr3:38204745-38204825 1.0000 80 chr6:31810437-31810517 1.0000 80 chr8:144397158-144397238 1.0000 80 chr22:18263807-18263887 1.0000 80 chr1:226158605-226158685 1.0000 80 chr9:131410630-131410710 1.0000 80 chr11:64528038-64528118 1.0000 80 chr7:99013275-99013355 1.0000 80 chr4:109052212-109052292 1.0000 80 chrX:49013647-49013727 1.0000 80 chr9:133567881-133567961 1.0000 80 chr1:180024785-180024865 1.0000 80 chr11:74851723-74851803 1.0000 80 chrX:47666158-47666238 1.0000 80 chr16:2550768-2550848 1.0000 80 chr1:246810570-246810650 1.0000 80 chr1:198668743-198668823 1.0000 80 chr14:106947983-10694806 1.0000 80 chr9:132481562-132481642 1.0000 80 chr20:31123266-31123346 1.0000 80 chr19:628355-628435 1.0000 80 chr1:246737447-246737527 1.0000 80 chr2:10933297-10933377 1.0000 80 chr11:107897909-10789798 1.0000 80 chr16:85083615-85083695 1.0000 80 chr16:30989082-30989162 1.0000 80 chr10:3135932-3136012 1.0000 80 chr1:10590459-10590539 1.0000 80 chr3:176862389-176862469 1.0000 80 chr1:41583041-41583121 1.0000 80 chr10:1156107-1156187 1.0000 80 chr16:2655500-2655580 1.0000 80 chr2:44125572-44125652 1.0000 80 chr1:173532118-173532198 1.0000 80 chr19:13915697-13915777 1.0000 80 chr12:132536426-13253650 1.0000 80 chr13:114275976-11427605 1.0000 80 chr9:130839506-130839586 1.0000 80 chr19:50416739-50416819 1.0000 80 chr16:30568329-30568409 1.0000 80 chr15:96897208-96897288 1.0000 80 chr2:170681873-170681953 1.0000 80 chr17:40431469-40431549 1.0000 80 chr12:93678232-93678312 1.0000 80 chr2:153611691-153611771 1.0000 80 chr1:33235891-33235971 1.0000 80 chr7:148769087-148769167 1.0000 80 chr11:116765921-11676600 1.0000 80 chr8:141348940-141349020 1.0000 80 chr19:10463477-10463557 1.0000 80 chr10:98594727-98594807 1.0000 80 chr21:47602631-47602711 1.0000 80 chr4:127872579-127872659 1.0000 80 chr19:19014074-19014154 1.0000 80 chr17:46711529-46711609 1.0000 80 chr17:27944239-27944319 1.0000 80 chr19:38942418-38942498 1.0000 80 chr7:157198827-157198907 1.0000 80 chr10:21881463-21881543 1.0000 80 chr5:179228905-179228985 1.0000 80 chr6:27139705-27139785 1.0000 80 chr1:246724303-246724383 1.0000 80 chr9:127939546-127939626 1.0000 80 chr6:27527398-27527478 1.0000 80 chr16:18813857-18813937 1.0000 80 chr8:145792769-145792849 1.0000 80 chr22:49909337-49909417 1.0000 80 chr7:138789294-138789374 1.0000 80 chr19:40741725-40741805 1.0000 80 chr9:135916508-135916588 1.0000 80 chr17:37071351-37071431 1.0000 80 chr1:51852079-51852159 1.0000 80 chr6:170097391-170097471 1.0000 80 chr16:28961578-28961658 1.0000 80 chr19:7067278-7067358 1.0000 80 chr16:2007499-2007579 1.0000 80 chr16:84637000-84637080 1.0000 80 chr9:140453795-140453875 1.0000 80 chr6:171021965-171022045 1.0000 80 chr9:130943918-130943998 1.0000 80 chr7:38787785-38787865 1.0000 80 chr14:77505105-77505185 1.0000 80 chr7:23502080-23502160 1.0000 80 chr4:74537188-74537268 1.0000 80 chr9:130732418-130732498 1.0000 80 chr1:8458878-8458958 1.0000 80 chr16:85391673-85391753 1.0000 80 chr20:62204387-62204467 1.0000 80 chr7:98719350-98719430 1.0000 80 chr16:87891836-87891916 1.0000 80 chr9:131107397-131107477 1.0000 80 chr7:151094746-151094826 1.0000 80 chr19:55783661-55783741 1.0000 80 chr15:101810191-10181027 1.0000 80 chr10:76844884-76844964 1.0000 80 chr6:43966749-43966829 1.0000 80 chr17:66018828-66018908 1.0000 80 chr6:17817295-17817375 1.0000 80 chr4:83809683-83809763 1.0000 80 chr6:26272546-26272626 1.0000 80 chr10:30721711-30721791 1.0000 80 chr1:171729933-171730013 1.0000 80 chr1:29325741-29325821 1.0000 80 chr3:5231355-5231435 1.0000 80 chr3:141564406-141564486 1.0000 80 chr1:155660753-155660833 1.0000 80 chr10:69523355-69523435 1.0000 80 chr2:74688688-74688768 1.0000 80 chr10:70886056-70886136 1.0000 80 chr6:44033331-44033411 1.0000 80 chr4:83929677-83929757 1.0000 80 chr6:26225478-26225558 1.0000 80 chr8:130871739-130871819 1.0000 80 chr15:42859542-42859622 1.0000 80 chr6:49597579-49597659 1.0000 80 chr9:140405812-140405892 1.0000 80 chr22:18231512-18231592 1.0000 80 chr7:150013635-150013715 1.0000 80 chr19:28293362-28293442 1.0000 80 chr1:165740531-165740611 1.0000 80 chr9:135900862-135900942 1.0000 80 chr15:93350861-93350941 1.0000 80 chr17:80735776-80735856 1.0000 80 chr15:76601628-76601708 1.0000 80 chr17:3538715-3538795 1.0000 80 chr15:91567112-91567192 1.0000 80 chr20:46242385-46242465 1.0000 80 chr7:150830843-150830923 1.0000 80 chr17:61514218-61514298 1.0000 80 chr17:74299628-74299708 1.0000 80 chr18:77742864-77742944 1.0000 80 chr12:110871550-11087163 1.0000 80 chr3:19999056-19999136 1.0000 80 chr18:9404058-9404138 1.0000 80 chr6:17947949-17948029 1.0000 80 chr20:49998271-49998351 1.0000 80 chr15:70727040-70727120 1.0000 80 chr1:1187949-1188029 1.0000 80 chr2:43423398-43423478 1.0000 80 chr7:50518452-50518532 1.0000 80 chr12:1820162-1820242 1.0000 80 chr15:85478266-85478346 1.0000 80 chr16:88679832-88679912 1.0000 80 chr1:17003300-17003380 1.0000 80 chr10:21472236-21472316 1.0000 80 chr17:64306903-64306983 1.0000 80 chr19:46232051-46232131 1.0000 80 chr2:122096132-122096212 1.0000 80 chr1:100070619-100070699 1.0000 80 chr1:180470543-180470623 1.0000 80 chr3:128151138-128151218 1.0000 80 chr1:153770050-153770130 1.0000 80 chr10:76146735-76146815 1.0000 80 chr8:103603970-103604050 1.0000 80 chr1:46212752-46212832 1.0000 80 chr16:57760011-57760091 1.0000 80 chr19:11680973-11681053 1.0000 80 chr5:118411149-118411229 1.0000 80 chr9:37753126-37753206 1.0000 80 chr11:5387778-5387858 1.0000 80 chr1:167912287-167912367 1.0000 80 chr15:78292512-78292592 1.0000 80 chr6:43170891-43170971 1.0000 80 chr1:16203061-16203141 1.0000 80 chr19:42348894-42348974 1.0000 80 chr6:52157020-52157100 1.0000 80 chr21:15906907-15906987 1.0000 80 chr10:961636-961716 1.0000 80 chr19:49438219-49438299 1.0000 80 chr15:90641991-90642071 1.0000 80 chr15:97034561-97034641 1.0000 80 chr1:1657676-1657756 1.0000 80 chr6:106769324-106769404 1.0000 80 chr1:180577868-180577948 1.0000 80 chr4:151930829-151930909 1.0000 80 chr7:156943661-156943741 1.0000 80 chr19:1987547-1987627 1.0000 80 chr8:144563694-144563774 1.0000 80 chr7:135656943-135657023 1.0000 80 chr1:8879016-8879096 1.0000 80 chr10:126640217-12664029 1.0000 80 chr5:131087798-131087878 1.0000 80 chr10:80981076-80981156 1.0000 80 chr15:66080501-66080581 1.0000 80 chr16:89391966-89392046 1.0000 80 chr6:134285043-134285123 1.0000 80 chr1:31372207-31372287 1.0000 80 chr3:151837868-151837948 1.0000 80 chr15:65901303-65901383 1.0000 80 chr1:29256116-29256196 1.0000 80 chr1:65707402-65707482 1.0000 80 chr17:44258822-44258902 1.0000 80 chr17:73495198-73495278 1.0000 80 chr17:47113530-47113610 1.0000 80 chr1:223947018-223947098 1.0000 80 chr15:65589661-65589741 1.0000 80 chr21:47562487-47562567 1.0000 80 chr8:124139008-124139088 1.0000 80 chr10:73575443-73575523 1.0000 80 chr5:61600917-61600997 1.0000 80 chr6:76397831-76397911 1.0000 80 chr6:3159517-3159597 1.0000 80 chr5:139683732-139683812 1.0000 80 chr1:27332729-27332809 1.0000 80 chr5:90303222-90303302 1.0000 80 chr6:28952672-28952752 1.0000 80 chr20:62370304-62370384 1.0000 80 chr1:179874371-179874451 1.0000 80 chr6:106774232-106774312 1.0000 80 chr12:125421909-12542198 1.0000 80 chr6:26240757-26240837 1.0000 80 chr6:30638613-30638693 1.0000 80 chr7:2138799-2138879 1.0000 80 chr6:47412111-47412191 1.0000 80 chr1:27873839-27873919 1.0000 80 chr1:78384742-78384822 1.0000 80 chr1:235466303-235466383 1.0000 80 chr1:40647989-40648069 1.0000 80 chr22:29709276-29709356 1.0000 80 chr6:28955625-28955705 1.0000 80 chr17:80841082-80841162 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_ZBTB33/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/ZBTB33.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.199 C 0.313 G 0.299 T 0.189 Background letter frequencies (from file dataset with add-one prior applied): A 0.199 C 0.313 G 0.299 T 0.189 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF GAYTACAG MEME-1 width = 8 sites = 46 llr = 411 E-value = 6.0e-025 ******************************************************************************** -------------------------------------------------------------------------------- Motif GAYTACAG MEME-1 Description -------------------------------------------------------------------------------- Simplified A 1a::7:a: pos.-specific C 2:6:3a:: probability G 7::::::a matrix T ::4a:::: bits 2.4 * * * 2.2 * * * 1.9 * * * 1.7 * * ** Relative 1.4 * * *** Entropy 1.2 * ***** (12.9 bits) 1.0 ******* 0.7 ******* 0.5 ******** 0.2 ******** 0.0 -------- Multilevel GACTACAG consensus C T C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GAYTACAG MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:235466303-235466383 71 2.09e-05 gactagctgg gactacag gc chr6:28952672-28952752 58 2.09e-05 aaagtgctga gattacag gcgtgagcta chr5:139683732-139683812 68 2.09e-05 gtagcgctgg gactacag gcgcg chr1:65707402-65707482 47 2.09e-05 aaagtgctgg gattacag gcgtgagccg chr15:65901303-65901383 68 2.09e-05 gagtagccgg gactacag gcgcg chr15:66080501-66080581 49 2.09e-05 gagtagctgg gactacag gcgcctgcca chr6:106769324-106769404 45 2.09e-05 gagtagctgg gactacag gcgcccgcca chr21:15906907-15906987 65 2.09e-05 aagtagctgg gattacag gtgcccgc chr5:118411149-118411229 55 2.09e-05 cacgtactgg gattacag gcgtgagcca chr1:153770050-153770130 60 2.09e-05 gcgtagctgg gactacag gcgcccgcca chr1:180470543-180470623 55 2.09e-05 gagtagctgg gattacag gcatgcgcca chr1:100070619-100070699 48 2.09e-05 aaagtgctgg gattacag gcgtgagcaa chr12:110871550-11087163 40 2.09e-05 aaagtgttgg gattacag gcgtgagcta chr15:93350861-93350941 61 2.09e-05 aaagtgctgg gattacag gcgtgagcca chr3:5231355-5231435 66 2.09e-05 gagtagctgg gactacag actcgtg chr10:30721711-30721791 38 2.09e-05 aaagcgctgg gattacag gcgtgcgcaa chr16:28961578-28961658 7 2.09e-05 tgctgg gattacag gcgtgagcca chr16:18813857-18813937 20 2.09e-05 aaagtgctag gattacag gcgtgagcca chr10:21881463-21881543 58 2.09e-05 gcgtagctgg gactacag gcgcctgcca chr4:127872579-127872659 1 2.09e-05 . gactacag gcacccgcca chr10:98594727-98594807 66 2.09e-05 gagtagctgg gactacag gcgtgcg chr12:93678232-93678312 70 2.09e-05 gagtagctgg gactacag gcg chr10:3135932-3136012 39 2.09e-05 gagcagctgg gactacag gctcccgcca chr1:246737447-246737527 32 2.09e-05 gagtggctgg gactacag gcacccgcca chr1:180024785-180024865 32 2.09e-05 gagtagctgg gactacag cccccaccac chr4:109052212-109052292 54 2.09e-05 gagcagctgg gactacag gtggcgccac chr14:103763416-10376349 1 2.09e-05 . gattacag gcgtgagccc chr7:100231579-100231659 22 4.28e-05 aaagtgctgg cattacag gcgcgagccg chr10:73575443-73575523 26 7.57e-05 CCGGACACCC GACTCCAG TCCAAGTCTC chr5:61600917-61600997 63 1.24e-04 cgcgccactg cactccag cctgagcgac chr3:151837868-151837948 56 1.24e-04 cgcgccactg cactccag cctgggcgcc chr11:5387778-5387858 25 1.24e-04 cgcgccattg cactccag cagcctggaa chr19:46232051-46232131 7 1.24e-04 ccactg cattccag cctgtctggg chr3:19999056-19999136 63 1.24e-04 agcgccactg cattccag cctgagcaac chr17:66018828-66018908 71 1.24e-04 ggcgccagtg cactccag cc chr9:127939546-127939626 71 1.24e-04 ggcgccactg cactccag cc chr6:31810437-31810517 54 1.24e-04 cccgccactg cactccag cctgcgcgac chr7:2139990-2140070 69 1.24e-04 GGGGGTGCCA CACTCCAG ACAT chr9:37753126-37753206 54 1.46e-04 agaaggaaga aactccag acacgcagtc chr1:17003300-17003380 53 1.46e-04 CTGTGGGCTA AACTCCAG AAGCTGGCGC chr6:49597579-49597659 8 1.46e-04 cacccag aactccag ctggcccgca chr6:26272546-26272626 41 1.46e-04 GTTGCCCGCC AACTCCAG GATCTTGGCG chr6:43966749-43966829 36 1.46e-04 aggaacagac aactccag acgcgccgcc chr17:47113530-47113610 55 1.59e-04 TGGTGTGTGG TATTACAG CCCCGTGCTG chr1:29256116-29256196 63 1.79e-04 gagtagctgg gattagag gcatgcgcca chr3:141564406-141564486 18 1.79e-04 CAGGGGAGGT GACTAGAG AAGTGGCTGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GAYTACAG MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:235466303-235466383 2.1e-05 70_[+1]_2 chr6:28952672-28952752 2.1e-05 57_[+1]_15 chr5:139683732-139683812 2.1e-05 67_[+1]_5 chr1:65707402-65707482 2.1e-05 46_[+1]_26 chr15:65901303-65901383 2.1e-05 67_[+1]_5 chr15:66080501-66080581 2.1e-05 48_[+1]_24 chr6:106769324-106769404 2.1e-05 44_[+1]_28 chr21:15906907-15906987 2.1e-05 64_[+1]_8 chr5:118411149-118411229 2.1e-05 54_[+1]_18 chr1:153770050-153770130 2.1e-05 59_[+1]_13 chr1:180470543-180470623 2.1e-05 54_[+1]_18 chr1:100070619-100070699 2.1e-05 47_[+1]_25 chr12:110871550-11087163 2.1e-05 39_[+1]_33 chr15:93350861-93350941 2.1e-05 60_[+1]_12 chr3:5231355-5231435 2.1e-05 65_[+1]_7 chr10:30721711-30721791 2.1e-05 37_[+1]_35 chr16:28961578-28961658 2.1e-05 6_[+1]_66 chr16:18813857-18813937 2.1e-05 19_[+1]_53 chr10:21881463-21881543 2.1e-05 57_[+1]_15 chr4:127872579-127872659 2.1e-05 [+1]_72 chr10:98594727-98594807 2.1e-05 65_[+1]_7 chr12:93678232-93678312 2.1e-05 69_[+1]_3 chr10:3135932-3136012 2.1e-05 38_[+1]_34 chr1:246737447-246737527 2.1e-05 31_[+1]_41 chr1:180024785-180024865 2.1e-05 31_[+1]_41 chr4:109052212-109052292 2.1e-05 53_[+1]_19 chr14:103763416-10376349 2.1e-05 [+1]_72 chr7:100231579-100231659 4.3e-05 21_[+1]_51 chr10:73575443-73575523 7.6e-05 25_[+1]_47 chr5:61600917-61600997 0.00012 62_[+1]_10 chr3:151837868-151837948 0.00012 55_[+1]_17 chr11:5387778-5387858 0.00012 24_[+1]_48 chr19:46232051-46232131 0.00012 6_[+1]_66 chr3:19999056-19999136 0.00012 62_[+1]_10 chr17:66018828-66018908 0.00012 70_[+1]_2 chr9:127939546-127939626 0.00012 70_[+1]_2 chr6:31810437-31810517 0.00012 53_[+1]_19 chr7:2139990-2140070 0.00012 68_[+1]_4 chr9:37753126-37753206 0.00015 53_[+1]_19 chr1:17003300-17003380 0.00015 52_[+1]_20 chr6:49597579-49597659 0.00015 7_[+1]_65 chr6:26272546-26272626 0.00015 40_[+1]_32 chr6:43966749-43966829 0.00015 35_[+1]_37 chr17:47113530-47113610 0.00016 54_[+1]_18 chr1:29256116-29256196 0.00018 62_[+1]_10 chr3:141564406-141564486 0.00018 17_[+1]_55 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GAYTACAG MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GAYTACAG width=8 seqs=46 chr1:235466303-235466383 ( 71) GACTACAG 1 chr6:28952672-28952752 ( 58) GATTACAG 1 chr5:139683732-139683812 ( 68) GACTACAG 1 chr1:65707402-65707482 ( 47) GATTACAG 1 chr15:65901303-65901383 ( 68) GACTACAG 1 chr15:66080501-66080581 ( 49) GACTACAG 1 chr6:106769324-106769404 ( 45) GACTACAG 1 chr21:15906907-15906987 ( 65) GATTACAG 1 chr5:118411149-118411229 ( 55) GATTACAG 1 chr1:153770050-153770130 ( 60) GACTACAG 1 chr1:180470543-180470623 ( 55) GATTACAG 1 chr1:100070619-100070699 ( 48) GATTACAG 1 chr12:110871550-11087163 ( 40) GATTACAG 1 chr15:93350861-93350941 ( 61) GATTACAG 1 chr3:5231355-5231435 ( 66) GACTACAG 1 chr10:30721711-30721791 ( 38) GATTACAG 1 chr16:28961578-28961658 ( 7) GATTACAG 1 chr16:18813857-18813937 ( 20) GATTACAG 1 chr10:21881463-21881543 ( 58) GACTACAG 1 chr4:127872579-127872659 ( 1) GACTACAG 1 chr10:98594727-98594807 ( 66) GACTACAG 1 chr12:93678232-93678312 ( 70) GACTACAG 1 chr10:3135932-3136012 ( 39) GACTACAG 1 chr1:246737447-246737527 ( 32) GACTACAG 1 chr1:180024785-180024865 ( 32) GACTACAG 1 chr4:109052212-109052292 ( 54) GACTACAG 1 chr14:103763416-10376349 ( 1) GATTACAG 1 chr7:100231579-100231659 ( 22) CATTACAG 1 chr10:73575443-73575523 ( 26) GACTCCAG 1 chr5:61600917-61600997 ( 63) CACTCCAG 1 chr3:151837868-151837948 ( 56) CACTCCAG 1 chr11:5387778-5387858 ( 25) CACTCCAG 1 chr19:46232051-46232131 ( 7) CATTCCAG 1 chr3:19999056-19999136 ( 63) CATTCCAG 1 chr17:66018828-66018908 ( 71) CACTCCAG 1 chr9:127939546-127939626 ( 71) CACTCCAG 1 chr6:31810437-31810517 ( 54) CACTCCAG 1 chr7:2139990-2140070 ( 69) CACTCCAG 1 chr9:37753126-37753206 ( 54) AACTCCAG 1 chr1:17003300-17003380 ( 53) AACTCCAG 1 chr6:49597579-49597659 ( 8) AACTCCAG 1 chr6:26272546-26272626 ( 41) AACTCCAG 1 chr6:43966749-43966829 ( 36) AACTCCAG 1 chr17:47113530-47113610 ( 55) TATTACAG 1 chr1:29256116-29256196 ( 63) GATTAGAG 1 chr3:141564406-141564486 ( 18) GACTAGAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GAYTACAG MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.03184 E= 6.0e-025 -87 -53 113 -312 233 -1217 -1217 -1217 -1217 101 -1217 97 -1217 -1217 -1217 240 176 6 -1217 -1217 -1217 161 -278 -1217 233 -1217 -1217 -1217 -1217 -1217 174 -1217 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GAYTACAG MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 46 E= 6.0e-025 0.108696 0.217391 0.652174 0.021739 1.000000 0.000000 0.000000 0.000000 0.000000 0.630435 0.000000 0.369565 0.000000 0.000000 0.000000 1.000000 0.673913 0.326087 0.000000 0.000000 0.000000 0.956522 0.043478 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GAYTACAG MEME-1 regular expression -------------------------------------------------------------------------------- [GC]A[CT]T[AC]CAG -------------------------------------------------------------------------------- Time 5.01 secs. ******************************************************************************** ******************************************************************************** MOTIF CAGCCWCY MEME-2 width = 8 sites = 132 llr = 846 E-value = 9.3e-024 ******************************************************************************** -------------------------------------------------------------------------------- Motif CAGCCWCY MEME-2 Description -------------------------------------------------------------------------------- Simplified A :6::13:1 pos.-specific C a2:a6:a5 probability G :1a::::: matrix T :1::36:3 bits 2.4 2.2 1.9 1.7 * * Relative 1.4 * ** * Entropy 1.2 * ** ** (9.2 bits) 1.0 * ** ** 0.7 * ** *** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CAGCCTCC consensus C TA T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCCWCY MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:235466303-235466383 52 5.42e-05 tctcctgcct cagcctct cgactagctg chr5:139683732-139683812 9 5.42e-05 actcactc cagcctct acctcccgcg chr15:65901303-65901383 49 5.42e-05 tctcctgcct cagcctcc cgagtagccg chr15:66080501-66080581 30 5.42e-05 tctcctgcct cagcctcc cgagtagctg chr5:131087798-131087878 55 5.42e-05 tctcctgcct cagcctcc cgagtagctg chr6:106769324-106769404 26 5.42e-05 tctcctgcct cagcctcc cgagtagctg chr21:15906907-15906987 46 5.42e-05 tctcctgcct cagcctcc caagtagctg chr10:76146735-76146815 38 5.42e-05 tggctcactg cagcctcc acctcctgag chr1:153770050-153770130 41 5.42e-05 tctcttgcct cagcctcc cgcgtagctg chr1:180470543-180470623 36 5.42e-05 tccgcctcct cagcctcc cgagtagctg chr1:100070619-100070699 29 5.42e-05 ctgcccgcct cagcctcc caaagtgctg chr7:150013635-150013715 56 5.42e-05 tctcctgcct cagcctcc tgagcagctg chr1:155660753-155660833 62 5.42e-05 tctcctacct cagcctcc tgagtagctg chr3:5231355-5231435 47 5.42e-05 tctcctgcct cagcctcc cgagtagctg chr15:101810191-10181027 64 5.42e-05 AGCCCCACAG CAGCCTCT GCTGGTGGA chr9:130732418-130732498 53 5.42e-05 ccgcacgctg cagcctct gcctcccgag chr6:27527398-27527478 57 5.42e-05 tctcctgcct cagcctcc caagtagctg chr10:21881463-21881543 39 5.42e-05 tctcctgcct cagcctcc cgcgtagctg chr10:98594727-98594807 47 5.42e-05 tcttctgcgt cagcctcc cgagtagctg chr12:93678232-93678312 51 5.42e-05 tctcctgcct cagcctcc tgagtagctg chr10:3135932-3136012 20 5.42e-05 tctcccgcct cagcctcc cgagcagctg chr1:246737447-246737527 13 5.42e-05 tctcccgcct cagcctcc ggagtggctg chr1:180024785-180024865 13 5.42e-05 tctcctgcct cagcctcc tgagtagctg chr5:115422171-115422251 63 5.42e-05 cggctcactg cagcctcc gcctcctgtg chr1:8879016-8879096 59 8.69e-05 tctcctgcct cagcttcc cgagtagctg chr7:148769087-148769167 18 8.69e-05 GCAGCAGACA CAGCTTCC GGCGGAAGCT chr8:141348940-141349020 17 1.44e-04 CGCCACCAGA CAGCCACC TACAGGCCGA chr1:40647989-40648069 1 2.00e-04 . cagctact taggaggctg chr1:179874371-179874451 23 2.00e-04 cctgtagtcc cagctact cgggaggctg chr6:3159517-3159597 11 2.00e-04 tctatagtcc cagctact cgggaggctg chr6:134285043-134285123 20 2.00e-04 cctgtagtcg cagctact cgggaggctg chr6:52157020-52157100 60 2.00e-04 cctgtagtcc cagctact cgcgaggctg chr6:17947949-17948029 7 2.00e-04 taatcc cagctact caagaggctg chr15:76601628-76601708 48 2.00e-04 cctgtagtcc cagctact caggaggctg chr1:165740531-165740611 44 2.00e-04 cctgtagtcc cagctact cgggaggctg chr4:83929677-83929757 12 2.00e-04 cctgtagtcc cagctact cagggggctg chr6:44033331-44033411 6 2.00e-04 CACCC CAGCCTCA CATGTCCGCT chr1:29325741-29325821 25 2.00e-04 cctgtagtac cagctact tgggaggctg chr1:33235891-33235971 49 2.00e-04 TCGGCCAGCC CAGCCTCA GTCCGCTCGC chr16:30568329-30568409 16 2.00e-04 cctgtagtcc cagctact ggggaggctg chr3:176862389-176862469 37 2.00e-04 cctgtagttc cagctact cagaggctga chr14:103763416-10376349 55 2.00e-04 GGCTTTGCGG CAGCCTCA CACGTAGCCC chr20:49998271-49998351 15 2.34e-04 gggtactctg cagcatcc cctggtggca chr18:77742864-77742944 24 2.34e-04 AAACATCCAG CAGCATCT GCTGGTGGCG chr6:170097391-170097471 37 2.34e-04 gcggtaacgc cagcatct gggaagatgc chr21:47602631-47602711 7 2.34e-04 CCGCCG CAGCATCT GATTCTCCTT chr19:10463477-10463557 51 2.34e-04 TCATGATACC CAGCATCC GTCTACTCCA chr2:153611691-153611771 27 2.34e-04 gcggtaacgc cagcatct gcgaagacac chr20:62245737-62245817 38 2.34e-04 gcggtaacgc cagcatct gggaagacgc chr20:34274950-34275030 26 2.34e-04 gcggtaacgc cagcatct gggaagacgc chr12:133387244-13338732 20 2.34e-04 gcggtaacgc cagcatct gggaagacgc chr8:124139008-124139088 58 3.20e-04 actgcaacct ccgcctcc caagttcaag chr17:44258822-44258902 58 3.20e-04 actgcaacct ccgcctcc caggttcaaa chr11:107897909-10789798 39 3.20e-04 actgcaacct ccgcctcc aggccttagt chr19:628355-628435 49 3.20e-04 AGGCAGCACG CCGCCTCC ACCTCGCGGT chr9:37753126-37753206 5 3.33e-04 tctg cagcttca ctcctgaagc chr1:226158605-226158685 29 3.33e-04 cgaaggtctg cagcttca cttctgaagc chr7:2138799-2138879 64 4.58e-04 CAACATGCAG CAGCCACA GCCTGTCTC chr5:90303222-90303302 42 4.58e-04 CATCCTGCTA CTGCCTCT TGTGGTCACG chr1:29256116-29256196 12 4.58e-04 accgcaatct ctgcctcc cgggttcaag chr6:43170891-43170971 6 4.58e-04 CTGAA CCGCTTCT GGCCCATCAT chr17:61514218-61514298 1 4.58e-04 . CCGCTTCC TGGATCCCTG chr16:87891836-87891916 3 4.58e-04 AA CTGCCTCC TGCTGCATGG chr16:85391673-85391753 57 4.58e-04 CCACTCCCGC CAGCCACA GGCGTGCTGT chr17:40431469-40431549 20 4.58e-04 TGGTTTGTGG CAGCCACA GGGCGCTAGT chr19:50416739-50416819 12 4.58e-04 gacctcagtt cagccaca cgggtgcgcc chr16:30989082-30989162 33 4.58e-04 AGGTGAATCG CTGCCTCC TAGGGCCGGG chr9:132630169-132630249 73 4.58e-04 CTGGTTCCTC CTGCCTCC chr6:28952672-28952752 39 5.76e-04 ccgcccgcct cggcctcc caaagtgctg chr1:65707402-65707482 28 5.76e-04 ccgcctgtct cggcctcc caaagtgctg chr15:90641991-90642071 36 5.76e-04 ccgcctgctt cggcctcc caaagtcctg chr5:118411149-118411229 36 5.76e-04 ccgcccacct cggcctcc ccacgtactg chr17:3538715-3538795 65 5.76e-04 ccgcccgcct cggcctcc caaagcgc chr15:93350861-93350941 42 5.76e-04 ccgcccgcct cggcctcc caaagtgctg chr10:30721711-30721791 20 5.76e-04 cctcccgcct cggcctcc aaagcgctgg chr16:18813857-18813937 1 5.76e-04 . cggcctcc caaagtgcta chr19:19014074-19014154 35 5.76e-04 AGGCCCTCAG CGGCCTCC CAGCGGCCCT chr11:116765921-11676600 28 5.76e-04 tccatccccg cggcctct gcgctgaccc chr6:15512601-15512681 32 5.76e-04 TGAGCAGAGC CGGCCTCC TCCCGCTTGC chr7:100231579-100231659 3 5.76e-04 ct cggcctcc caaagtgctg chr1:167912287-167912367 5 6.65e-04 gcac ccgccacc acgcccggct chr1:171729933-171730013 4 6.65e-04 cgc ccgccacc gcgcccggct chr19:55783661-55783741 45 6.65e-04 gcactgccac ccgccacc actcggggac chr7:23502080-23502160 48 6.65e-04 ctaaaggcga ccgccacc acgcccggtt chr4:127872579-127872659 13 6.65e-04 ctacaggcac ccgccacc acgcccggct chr20:31123266-31123346 28 6.65e-04 GTAGCTGCCG CCGCCACC GCCACCACCG chr16:2550768-2550848 11 6.65e-04 GGCAGTCAGG CCGCCACT GACCTGAGCA chr11:74851723-74851803 18 6.65e-04 ATACTCATCA CCGCCACC ATCCTCGCTG chr6:31810437-31810517 45 6.65e-04 agtcaagatc ccgccact gcactccagc chr6:44195308-44195388 47 6.65e-04 TCGGCTCCTC CCGCCACC ACTGTGGGGA chr9:139870181-139870261 19 6.65e-04 CCCGGGCCAC CCGCCACC ACACCCCAGA chr11:57080018-57080098 51 6.65e-04 CCGCCTTGCA CCGCCACC ACTGGGTGGT chr3:141564406-141564486 60 7.10e-04 GTCTGCGCTT CTGCTTCT ATGCAGGACC chr7:2139990-2140070 47 7.10e-04 CGTGAAGCAC CTGCTTCC TGGAGGGGGT chr15:96897208-96897288 56 7.73e-04 GCCCTCCGAC CGGCTTCT CCCAGTCCCC chr16:4311731-4311811 58 7.73e-04 CCTGCTCCTC CAGCATCA TGCGCACCGA chr9:135900862-135900942 28 8.25e-04 gcggtaatgc cagcgtct gggaagacgc chr9:130943918-130943998 27 8.25e-04 gcggtgacgc cagcgtct gggaagacgc chr8:145792769-145792849 6 8.25e-04 aacgc cagcgtct gggaagacac chr13:114275976-11427605 34 8.25e-04 gcggtaacgc cagcgtct gggaagatgt chr1:41583041-41583121 30 8.25e-04 gcggtaacac cagcgtct gggaagacgc chr8:144397158-144397238 17 8.25e-04 gcggtaacgc cagcgtct gggaagatgc chr20:62370304-62370384 5 1.00e-03 CGCC CCGCCTCA CAGCTGACAG chr4:83809683-83809763 43 1.00e-03 ccagtagtcc ccgctact cgggagactg chr6:17817295-17817375 22 1.00e-03 GCGGTCAGGG CCGCTACT CTGTGGCTGC chr9:140453795-140453875 42 1.00e-03 ggaaaaacac ccgctact tagcagacct chr9:135916508-135916588 59 1.00e-03 ggaaaaacac ccgctact tagcagacct chr2:44125572-44125652 44 1.00e-03 GACTGTTTGA CTGCCACC TGCTGGGAAG chr2:10933297-10933377 25 1.00e-03 TTCACCAGTT CTGCCACC TACAGGAGAC chr4:109052212-109052292 29 1.00e-03 aagtgatcct ccgcctca gccgccagag chr3:46965132-46965212 69 1.00e-03 GGAAAACGCG CTGCCACT CTGC chr1:8458878-8458958 51 1.14e-03 tcaatgtgcg cggccact aggagtacat chr1:223947018-223947098 55 1.24e-03 AGGTGCTCAA CCGCTTCA AGCTGCCGCC chr19:28293362-28293442 40 1.24e-03 tggcaacggg catcttcc cagacgatgg chr8:130871739-130871819 73 1.24e-03 tggcaacggc catcttcc chr14:106947983-10694806 50 1.24e-03 tggcaacggg catcttcc cagaagctgg chr7:99013275-99013355 25 1.24e-03 tggcaacggg catcttcc cagatgctgg chr19:32868131-32868211 42 1.24e-03 tggcaatggg catcttcc cagatgctgg chr16:88679832-88679912 63 1.37e-03 cgccatctct ctgcatcc ttgtctgcac chr17:47113530-47113610 32 1.47e-03 GTTGGGGCTG CGGCATCT GCTGGTGGTG chr10:73575443-73575523 53 1.60e-03 CGCTACATTT CCGCCACA TCCCTCTCTG chr8:144563694-144563774 65 1.60e-03 CTGCCAAGCG CCGCCACA CGGTGGAG chr10:80981076-80981156 18 1.75e-03 GTCACTGCAG CAGCCGCC AGGCAGGCGG chr10:21472236-21472316 56 1.75e-03 gaggggagag CCGCAACC ACAGGACAAG chr7:50518452-50518532 17 1.75e-03 TCGGGAAAGC CAGCCGCC ATCCTGTGCT chr6:171021965-171022045 56 1.75e-03 CCACGTGCGC CAGCCGCC AGGCCTGGGC chr19:7067278-7067358 53 1.75e-03 ggcgtcttcc cagccgct ggcgttaccg chr5:156751382-156751462 23 1.75e-03 TGCTACTCAG CCGCAACC AAGCGCTAAT chr10:1156107-1156187 31 1.90e-03 GTTGGACATT GAGCTTCC CCTCACCGGC chr3:38204745-38204825 44 1.90e-03 GCTCAGCGCA GAGCTTCC AGTGCTTGGC chr15:78292512-78292592 39 2.31e-03 ACCGTACCGC GAGCCACT CAGAAGGAGG chr16:28961578-28961658 19 2.31e-03 ttacaggcgt gagccacc gcgcgcggcc -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCCWCY MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:235466303-235466383 5.4e-05 51_[+2]_21 chr5:139683732-139683812 5.4e-05 8_[+2]_64 chr15:65901303-65901383 5.4e-05 48_[+2]_24 chr15:66080501-66080581 5.4e-05 29_[+2]_43 chr5:131087798-131087878 5.4e-05 54_[+2]_18 chr6:106769324-106769404 5.4e-05 25_[+2]_47 chr21:15906907-15906987 5.4e-05 45_[+2]_27 chr10:76146735-76146815 5.4e-05 37_[+2]_35 chr1:153770050-153770130 5.4e-05 40_[+2]_32 chr1:180470543-180470623 5.4e-05 35_[+2]_37 chr1:100070619-100070699 5.4e-05 28_[+2]_44 chr7:150013635-150013715 5.4e-05 55_[+2]_17 chr1:155660753-155660833 5.4e-05 61_[+2]_11 chr3:5231355-5231435 5.4e-05 46_[+2]_26 chr15:101810191-10181027 5.4e-05 63_[+2]_9 chr9:130732418-130732498 5.4e-05 52_[+2]_20 chr6:27527398-27527478 5.4e-05 56_[+2]_16 chr10:21881463-21881543 5.4e-05 38_[+2]_34 chr10:98594727-98594807 5.4e-05 46_[+2]_26 chr12:93678232-93678312 5.4e-05 50_[+2]_22 chr10:3135932-3136012 5.4e-05 19_[+2]_53 chr1:246737447-246737527 5.4e-05 12_[+2]_60 chr1:180024785-180024865 5.4e-05 12_[+2]_60 chr5:115422171-115422251 5.4e-05 62_[+2]_10 chr1:8879016-8879096 8.7e-05 58_[+2]_14 chr7:148769087-148769167 8.7e-05 17_[+2]_55 chr8:141348940-141349020 0.00014 16_[+2]_56 chr1:40647989-40648069 0.0002 [+2]_72 chr1:179874371-179874451 0.0002 22_[+2]_50 chr6:3159517-3159597 0.0002 10_[+2]_62 chr6:134285043-134285123 0.0002 19_[+2]_53 chr6:52157020-52157100 0.0002 59_[+2]_13 chr6:17947949-17948029 0.0002 6_[+2]_66 chr15:76601628-76601708 0.0002 47_[+2]_25 chr1:165740531-165740611 0.0002 43_[+2]_29 chr4:83929677-83929757 0.0002 11_[+2]_61 chr6:44033331-44033411 0.0002 5_[+2]_67 chr1:29325741-29325821 0.0002 24_[+2]_48 chr1:33235891-33235971 0.0002 48_[+2]_24 chr16:30568329-30568409 0.0002 15_[+2]_57 chr3:176862389-176862469 0.0002 36_[+2]_36 chr14:103763416-10376349 0.0002 54_[+2]_18 chr20:49998271-49998351 0.00023 14_[+2]_58 chr18:77742864-77742944 0.00023 23_[+2]_49 chr6:170097391-170097471 0.00023 36_[+2]_36 chr21:47602631-47602711 0.00023 6_[+2]_66 chr19:10463477-10463557 0.00023 50_[+2]_22 chr2:153611691-153611771 0.00023 26_[+2]_46 chr20:62245737-62245817 0.00023 37_[+2]_35 chr20:34274950-34275030 0.00023 25_[+2]_47 chr12:133387244-13338732 0.00023 19_[+2]_53 chr8:124139008-124139088 0.00032 57_[+2]_15 chr17:44258822-44258902 0.00032 57_[+2]_15 chr11:107897909-10789798 0.00032 38_[+2]_34 chr19:628355-628435 0.00032 48_[+2]_24 chr9:37753126-37753206 0.00033 4_[+2]_68 chr1:226158605-226158685 0.00033 28_[+2]_44 chr7:2138799-2138879 0.00046 63_[+2]_9 chr5:90303222-90303302 0.00046 41_[+2]_31 chr1:29256116-29256196 0.00046 11_[+2]_61 chr6:43170891-43170971 0.00046 5_[+2]_67 chr17:61514218-61514298 0.00046 [+2]_72 chr16:87891836-87891916 0.00046 2_[+2]_70 chr16:85391673-85391753 0.00046 56_[+2]_16 chr17:40431469-40431549 0.00046 19_[+2]_53 chr19:50416739-50416819 0.00046 11_[+2]_61 chr16:30989082-30989162 0.00046 32_[+2]_40 chr9:132630169-132630249 0.00046 72_[+2] chr6:28952672-28952752 0.00058 38_[+2]_34 chr1:65707402-65707482 0.00058 27_[+2]_45 chr15:90641991-90642071 0.00058 35_[+2]_37 chr5:118411149-118411229 0.00058 35_[+2]_37 chr17:3538715-3538795 0.00058 64_[+2]_8 chr15:93350861-93350941 0.00058 41_[+2]_31 chr10:30721711-30721791 0.00058 19_[+2]_53 chr16:18813857-18813937 0.00058 [+2]_72 chr19:19014074-19014154 0.00058 34_[+2]_38 chr11:116765921-11676600 0.00058 27_[+2]_45 chr6:15512601-15512681 0.00058 31_[+2]_41 chr7:100231579-100231659 0.00058 2_[+2]_70 chr1:167912287-167912367 0.00067 4_[+2]_68 chr1:171729933-171730013 0.00067 3_[+2]_69 chr19:55783661-55783741 0.00067 44_[+2]_28 chr7:23502080-23502160 0.00067 47_[+2]_25 chr4:127872579-127872659 0.00067 12_[+2]_60 chr20:31123266-31123346 0.00067 27_[+2]_45 chr16:2550768-2550848 0.00067 10_[+2]_62 chr11:74851723-74851803 0.00067 17_[+2]_55 chr6:31810437-31810517 0.00067 44_[+2]_28 chr6:44195308-44195388 0.00067 46_[+2]_26 chr9:139870181-139870261 0.00067 18_[+2]_54 chr11:57080018-57080098 0.00067 50_[+2]_22 chr3:141564406-141564486 0.00071 59_[+2]_13 chr7:2139990-2140070 0.00071 46_[+2]_26 chr15:96897208-96897288 0.00077 55_[+2]_17 chr16:4311731-4311811 0.00077 57_[+2]_15 chr9:135900862-135900942 0.00082 27_[+2]_45 chr9:130943918-130943998 0.00082 26_[+2]_46 chr8:145792769-145792849 0.00082 5_[+2]_67 chr13:114275976-11427605 0.00082 33_[+2]_39 chr1:41583041-41583121 0.00082 29_[+2]_43 chr8:144397158-144397238 0.00082 16_[+2]_56 chr20:62370304-62370384 0.001 4_[+2]_68 chr4:83809683-83809763 0.001 42_[+2]_30 chr6:17817295-17817375 0.001 21_[+2]_51 chr9:140453795-140453875 0.001 41_[+2]_31 chr9:135916508-135916588 0.001 58_[+2]_14 chr2:44125572-44125652 0.001 43_[+2]_29 chr2:10933297-10933377 0.001 24_[+2]_48 chr4:109052212-109052292 0.001 28_[+2]_44 chr3:46965132-46965212 0.001 68_[+2]_4 chr1:8458878-8458958 0.0011 50_[+2]_22 chr1:223947018-223947098 0.0012 54_[+2]_18 chr19:28293362-28293442 0.0012 39_[+2]_33 chr8:130871739-130871819 0.0012 72_[+2] chr14:106947983-10694806 0.0012 49_[+2]_23 chr7:99013275-99013355 0.0012 24_[+2]_48 chr19:32868131-32868211 0.0012 41_[+2]_31 chr16:88679832-88679912 0.0014 62_[+2]_10 chr17:47113530-47113610 0.0015 31_[+2]_41 chr10:73575443-73575523 0.0016 52_[+2]_20 chr8:144563694-144563774 0.0016 64_[+2]_8 chr10:80981076-80981156 0.0018 17_[+2]_55 chr10:21472236-21472316 0.0018 55_[+2]_17 chr7:50518452-50518532 0.0018 16_[+2]_56 chr6:171021965-171022045 0.0018 55_[+2]_17 chr19:7067278-7067358 0.0018 52_[+2]_20 chr5:156751382-156751462 0.0018 22_[+2]_50 chr10:1156107-1156187 0.0019 30_[+2]_42 chr3:38204745-38204825 0.0019 43_[+2]_29 chr15:78292512-78292592 0.0023 38_[+2]_34 chr16:28961578-28961658 0.0023 18_[+2]_54 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCCWCY MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CAGCCWCY width=8 seqs=132 chr1:235466303-235466383 ( 52) CAGCCTCT 1 chr5:139683732-139683812 ( 9) CAGCCTCT 1 chr15:65901303-65901383 ( 49) CAGCCTCC 1 chr15:66080501-66080581 ( 30) CAGCCTCC 1 chr5:131087798-131087878 ( 55) CAGCCTCC 1 chr6:106769324-106769404 ( 26) CAGCCTCC 1 chr21:15906907-15906987 ( 46) CAGCCTCC 1 chr10:76146735-76146815 ( 38) CAGCCTCC 1 chr1:153770050-153770130 ( 41) CAGCCTCC 1 chr1:180470543-180470623 ( 36) CAGCCTCC 1 chr1:100070619-100070699 ( 29) CAGCCTCC 1 chr7:150013635-150013715 ( 56) CAGCCTCC 1 chr1:155660753-155660833 ( 62) CAGCCTCC 1 chr3:5231355-5231435 ( 47) CAGCCTCC 1 chr15:101810191-10181027 ( 64) CAGCCTCT 1 chr9:130732418-130732498 ( 53) CAGCCTCT 1 chr6:27527398-27527478 ( 57) CAGCCTCC 1 chr10:21881463-21881543 ( 39) CAGCCTCC 1 chr10:98594727-98594807 ( 47) CAGCCTCC 1 chr12:93678232-93678312 ( 51) CAGCCTCC 1 chr10:3135932-3136012 ( 20) CAGCCTCC 1 chr1:246737447-246737527 ( 13) CAGCCTCC 1 chr1:180024785-180024865 ( 13) CAGCCTCC 1 chr5:115422171-115422251 ( 63) CAGCCTCC 1 chr1:8879016-8879096 ( 59) CAGCTTCC 1 chr7:148769087-148769167 ( 18) CAGCTTCC 1 chr8:141348940-141349020 ( 17) CAGCCACC 1 chr1:40647989-40648069 ( 1) CAGCTACT 1 chr1:179874371-179874451 ( 23) CAGCTACT 1 chr6:3159517-3159597 ( 11) CAGCTACT 1 chr6:134285043-134285123 ( 20) CAGCTACT 1 chr6:52157020-52157100 ( 60) CAGCTACT 1 chr6:17947949-17948029 ( 7) CAGCTACT 1 chr15:76601628-76601708 ( 48) CAGCTACT 1 chr1:165740531-165740611 ( 44) CAGCTACT 1 chr4:83929677-83929757 ( 12) CAGCTACT 1 chr6:44033331-44033411 ( 6) CAGCCTCA 1 chr1:29325741-29325821 ( 25) CAGCTACT 1 chr1:33235891-33235971 ( 49) CAGCCTCA 1 chr16:30568329-30568409 ( 16) CAGCTACT 1 chr3:176862389-176862469 ( 37) CAGCTACT 1 chr14:103763416-10376349 ( 55) CAGCCTCA 1 chr20:49998271-49998351 ( 15) CAGCATCC 1 chr18:77742864-77742944 ( 24) CAGCATCT 1 chr6:170097391-170097471 ( 37) CAGCATCT 1 chr21:47602631-47602711 ( 7) CAGCATCT 1 chr19:10463477-10463557 ( 51) CAGCATCC 1 chr2:153611691-153611771 ( 27) CAGCATCT 1 chr20:62245737-62245817 ( 38) CAGCATCT 1 chr20:34274950-34275030 ( 26) CAGCATCT 1 chr12:133387244-13338732 ( 20) CAGCATCT 1 chr8:124139008-124139088 ( 58) CCGCCTCC 1 chr17:44258822-44258902 ( 58) CCGCCTCC 1 chr11:107897909-10789798 ( 39) CCGCCTCC 1 chr19:628355-628435 ( 49) CCGCCTCC 1 chr9:37753126-37753206 ( 5) CAGCTTCA 1 chr1:226158605-226158685 ( 29) CAGCTTCA 1 chr7:2138799-2138879 ( 64) CAGCCACA 1 chr5:90303222-90303302 ( 42) CTGCCTCT 1 chr1:29256116-29256196 ( 12) CTGCCTCC 1 chr6:43170891-43170971 ( 6) CCGCTTCT 1 chr17:61514218-61514298 ( 1) CCGCTTCC 1 chr16:87891836-87891916 ( 3) CTGCCTCC 1 chr16:85391673-85391753 ( 57) CAGCCACA 1 chr17:40431469-40431549 ( 20) CAGCCACA 1 chr19:50416739-50416819 ( 12) CAGCCACA 1 chr16:30989082-30989162 ( 33) CTGCCTCC 1 chr9:132630169-132630249 ( 73) CTGCCTCC 1 chr6:28952672-28952752 ( 39) CGGCCTCC 1 chr1:65707402-65707482 ( 28) CGGCCTCC 1 chr15:90641991-90642071 ( 36) CGGCCTCC 1 chr5:118411149-118411229 ( 36) CGGCCTCC 1 chr17:3538715-3538795 ( 65) CGGCCTCC 1 chr15:93350861-93350941 ( 42) CGGCCTCC 1 chr10:30721711-30721791 ( 20) CGGCCTCC 1 chr16:18813857-18813937 ( 1) CGGCCTCC 1 chr19:19014074-19014154 ( 35) CGGCCTCC 1 chr11:116765921-11676600 ( 28) CGGCCTCT 1 chr6:15512601-15512681 ( 32) CGGCCTCC 1 chr7:100231579-100231659 ( 3) CGGCCTCC 1 chr1:167912287-167912367 ( 5) CCGCCACC 1 chr1:171729933-171730013 ( 4) CCGCCACC 1 chr19:55783661-55783741 ( 45) CCGCCACC 1 chr7:23502080-23502160 ( 48) CCGCCACC 1 chr4:127872579-127872659 ( 13) CCGCCACC 1 chr20:31123266-31123346 ( 28) CCGCCACC 1 chr16:2550768-2550848 ( 11) CCGCCACT 1 chr11:74851723-74851803 ( 18) CCGCCACC 1 chr6:31810437-31810517 ( 45) CCGCCACT 1 chr6:44195308-44195388 ( 47) CCGCCACC 1 chr9:139870181-139870261 ( 19) CCGCCACC 1 chr11:57080018-57080098 ( 51) CCGCCACC 1 chr3:141564406-141564486 ( 60) CTGCTTCT 1 chr7:2139990-2140070 ( 47) CTGCTTCC 1 chr15:96897208-96897288 ( 56) CGGCTTCT 1 chr16:4311731-4311811 ( 58) CAGCATCA 1 chr9:135900862-135900942 ( 28) CAGCGTCT 1 chr9:130943918-130943998 ( 27) CAGCGTCT 1 chr8:145792769-145792849 ( 6) CAGCGTCT 1 chr13:114275976-11427605 ( 34) CAGCGTCT 1 chr1:41583041-41583121 ( 30) CAGCGTCT 1 chr8:144397158-144397238 ( 17) CAGCGTCT 1 chr20:62370304-62370384 ( 5) CCGCCTCA 1 chr4:83809683-83809763 ( 43) CCGCTACT 1 chr6:17817295-17817375 ( 22) CCGCTACT 1 chr9:140453795-140453875 ( 42) CCGCTACT 1 chr9:135916508-135916588 ( 59) CCGCTACT 1 chr2:44125572-44125652 ( 44) CTGCCACC 1 chr2:10933297-10933377 ( 25) CTGCCACC 1 chr4:109052212-109052292 ( 29) CCGCCTCA 1 chr3:46965132-46965212 ( 69) CTGCCACT 1 chr1:8458878-8458958 ( 51) CGGCCACT 1 chr1:223947018-223947098 ( 55) CCGCTTCA 1 chr19:28293362-28293442 ( 40) CATCTTCC 1 chr8:130871739-130871819 ( 73) CATCTTCC 1 chr14:106947983-10694806 ( 50) CATCTTCC 1 chr7:99013275-99013355 ( 25) CATCTTCC 1 chr19:32868131-32868211 ( 42) CATCTTCC 1 chr16:88679832-88679912 ( 63) CTGCATCC 1 chr17:47113530-47113610 ( 32) CGGCATCT 1 chr10:73575443-73575523 ( 53) CCGCCACA 1 chr8:144563694-144563774 ( 65) CCGCCACA 1 chr10:80981076-80981156 ( 18) CAGCCGCC 1 chr10:21472236-21472316 ( 56) CCGCAACC 1 chr7:50518452-50518532 ( 17) CAGCCGCC 1 chr6:171021965-171022045 ( 56) CAGCCGCC 1 chr19:7067278-7067358 ( 53) CAGCCGCT 1 chr5:156751382-156751462 ( 23) CCGCAACC 1 chr10:1156107-1156187 ( 31) GAGCTTCC 1 chr3:38204745-38204825 ( 44) GAGCTTCC 1 chr15:78292512-78292592 ( 39) GAGCCACT 1 chr16:28961578-28961658 ( 19) GAGCCACC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCCWCY MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 7.87148 E= 9.3e-024 -1369 163 -330 -1369 155 -51 -139 -118 -1369 -1369 169 -232 -1369 168 -1369 -1369 -91 93 -272 40 71 -1369 -330 177 -1369 168 -1369 -1369 -81 80 -1369 85 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCCWCY MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 132 E= 9.3e-024 0.000000 0.969697 0.030303 0.000000 0.583333 0.219697 0.113636 0.083333 0.000000 0.000000 0.962121 0.037879 0.000000 1.000000 0.000000 0.000000 0.106061 0.598485 0.045455 0.250000 0.325758 0.000000 0.030303 0.643939 0.000000 1.000000 0.000000 0.000000 0.113636 0.545455 0.000000 0.340909 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCCWCY MEME-2 regular expression -------------------------------------------------------------------------------- C[AC]GC[CT][TA]C[CT] -------------------------------------------------------------------------------- Time 8.74 secs. ******************************************************************************** ******************************************************************************** MOTIF ATTCTCCT MEME-3 width = 8 sites = 19 llr = 220 E-value = 1.6e-018 ******************************************************************************** -------------------------------------------------------------------------------- Motif ATTCTCCT MEME-3 Description -------------------------------------------------------------------------------- Simplified A a::::::: pos.-specific C :::a:a9: probability G :::::::: matrix T :aa:a:1a bits 2.4 *** * * 2.2 *** * * 1.9 *** * * 1.7 ****** * Relative 1.4 ******** Entropy 1.2 ******** (16.7 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel ATTCTCCT consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTCTCCT MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:235466303-235466383 40 7.79e-06 ggttcacgcc attctcct gcctcagcct chr1:29256116-29256196 32 7.79e-06 ggttcaagcg attctcct gcctcagccc chr15:65901303-65901383 37 7.79e-06 ggttcacgcc attctcct gcctcagcct chr15:66080501-66080581 18 7.79e-06 ggttcacgcc attctcct gcctcagcct chr5:131087798-131087878 43 7.79e-06 ggttcgcgcc attctcct gcctcagcct chr1:8879016-8879096 47 7.79e-06 agttcaagcg attctcct gcctcagctt chr6:106769324-106769404 14 7.79e-06 ggttcacgcc attctcct gcctcagcct chr21:15906907-15906987 34 7.79e-06 ggttcacgcc attctcct gcctcagcct chr10:76146735-76146815 64 7.79e-06 agttcaagcg attctcct gcctcagcc chr7:150013635-150013715 44 7.79e-06 ggttcaagcg attctcct gcctcagcct chr1:155660753-155660833 50 7.79e-06 ggttcgcgcc attctcct acctcagcct chr3:5231355-5231435 35 7.79e-06 ggttaaagtg attctcct gcctcagcct chr7:23502080-23502160 5 7.79e-06 cgcc attctcct gcctcagcct chr6:27527398-27527478 45 7.79e-06 ggttcaagcg attctcct gcctcagcct chr10:21881463-21881543 27 7.79e-06 ggttcacgcc attctcct gcctcagcct chr21:47602631-47602711 16 7.79e-06 GCAGCATCTG ATTCTCCT TCAGGAGGCG chr12:93678232-93678312 39 7.79e-06 ggttcacgcc attctcct gcctcagcct chr1:180024785-180024865 1 7.79e-06 . attctcct gcctcagcct chr1:153770050-153770130 29 1.25e-05 ggttcaagcg attctctt gcctcagcct -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTCTCCT MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:235466303-235466383 7.8e-06 39_[+3]_33 chr1:29256116-29256196 7.8e-06 31_[+3]_41 chr15:65901303-65901383 7.8e-06 36_[+3]_36 chr15:66080501-66080581 7.8e-06 17_[+3]_55 chr5:131087798-131087878 7.8e-06 42_[+3]_30 chr1:8879016-8879096 7.8e-06 46_[+3]_26 chr6:106769324-106769404 7.8e-06 13_[+3]_59 chr21:15906907-15906987 7.8e-06 33_[+3]_39 chr10:76146735-76146815 7.8e-06 63_[+3]_9 chr7:150013635-150013715 7.8e-06 43_[+3]_29 chr1:155660753-155660833 7.8e-06 49_[+3]_23 chr3:5231355-5231435 7.8e-06 34_[+3]_38 chr7:23502080-23502160 7.8e-06 4_[+3]_68 chr6:27527398-27527478 7.8e-06 44_[+3]_28 chr10:21881463-21881543 7.8e-06 26_[+3]_46 chr21:47602631-47602711 7.8e-06 15_[+3]_57 chr12:93678232-93678312 7.8e-06 38_[+3]_34 chr1:180024785-180024865 7.8e-06 [+3]_72 chr1:153770050-153770130 1.2e-05 28_[+3]_44 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTCTCCT MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ATTCTCCT width=8 seqs=19 chr1:235466303-235466383 ( 40) ATTCTCCT 1 chr1:29256116-29256196 ( 32) ATTCTCCT 1 chr15:65901303-65901383 ( 37) ATTCTCCT 1 chr15:66080501-66080581 ( 18) ATTCTCCT 1 chr5:131087798-131087878 ( 43) ATTCTCCT 1 chr1:8879016-8879096 ( 47) ATTCTCCT 1 chr6:106769324-106769404 ( 14) ATTCTCCT 1 chr21:15906907-15906987 ( 34) ATTCTCCT 1 chr10:76146735-76146815 ( 64) ATTCTCCT 1 chr7:150013635-150013715 ( 44) ATTCTCCT 1 chr1:155660753-155660833 ( 50) ATTCTCCT 1 chr3:5231355-5231435 ( 35) ATTCTCCT 1 chr7:23502080-23502160 ( 5) ATTCTCCT 1 chr6:27527398-27527478 ( 45) ATTCTCCT 1 chr10:21881463-21881543 ( 27) ATTCTCCT 1 chr21:47602631-47602711 ( 16) ATTCTCCT 1 chr12:93678232-93678312 ( 39) ATTCTCCT 1 chr1:180024785-180024865 ( 1) ATTCTCCT 1 chr1:153770050-153770130 ( 29) ATTCTCTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTCTCCT MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.1012 E= 1.6e-018 233 -1089 -1089 -1089 -1089 -1089 -1089 240 -1089 -1089 -1089 240 -1089 167 -1089 -1089 -1089 -1089 -1089 240 -1089 167 -1089 -1089 -1089 160 -1089 -184 -1089 -1089 -1089 240 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTCTCCT MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 19 E= 1.6e-018 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.947368 0.000000 0.052632 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTCTCCT MEME-3 regular expression -------------------------------------------------------------------------------- ATTCTCCT -------------------------------------------------------------------------------- Time 12.24 secs. ******************************************************************************** ******************************************************************************** MOTIF AGTAGCTG MEME-4 width = 8 sites = 35 llr = 325 E-value = 3.0e-017 ******************************************************************************** -------------------------------------------------------------------------------- Motif AGTAGCTG MEME-4 Description -------------------------------------------------------------------------------- Simplified A 9:19:::: pos.-specific C 1:1::a:: probability G :911a::a matrix T :17:::a: bits 2.4 2.2 * 1.9 * * 1.7 * ***** Relative 1.4 ** ***** Entropy 1.2 ** ***** (13.4 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AGTAGCTG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTAGCTG MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:29256116-29256196 54 1.18e-05 cagcccgccg agtagctg ggattagagg chr15:66080501-66080581 40 1.18e-05 cagcctcccg agtagctg ggactacagg chr5:131087798-131087878 65 1.18e-05 cagcctcccg agtagctg ggactaca chr1:8879016-8879096 69 1.18e-05 cagcttcccg agtagctg agat chr6:106769324-106769404 36 1.18e-05 cagcctcccg agtagctg ggactacagg chr21:15906907-15906987 56 1.18e-05 cagcctccca agtagctg ggattacagg chr1:180470543-180470623 46 1.18e-05 cagcctcccg agtagctg ggattacagg chr1:155660753-155660833 72 1.18e-05 cagcctcctg agtagctg g chr3:5231355-5231435 57 1.18e-05 cagcctcccg agtagctg ggactacaga chr6:27527398-27527478 67 1.18e-05 cagcctccca agtagctg gaacta chr10:98594727-98594807 57 1.18e-05 cagcctcccg agtagctg ggactacagg chr12:93678232-93678312 61 1.18e-05 cagcctcctg agtagctg ggactacagg chr11:107897909-10789798 54 1.18e-05 tccaggcctt agtagctg ggattatagg chrX:47666158-47666238 60 1.18e-05 GCAGCCCAGC AGTAGCTG GAGAGGCAGG chr1:180024785-180024865 23 1.18e-05 cagcctcctg agtagctg ggactacagc chr16:88679832-88679912 11 3.14e-05 tgttgtgcag agcagctg caccttttac chr7:150013635-150013715 66 3.14e-05 cagcctcctg agcagctg ggactac chr19:40741725-40741805 29 3.14e-05 GGACAGTGGC AGCAGCTG GCGCTGGGCT chr10:3135932-3136012 30 3.14e-05 cagcctcccg agcagctg ggactacagg chr4:109052212-109052292 45 3.14e-05 cagccgccag agcagctg ggactacagg chr6:47412111-47412191 50 5.02e-05 actcgcggtc aggagctg gagaccagcc chr18:77742864-77742944 72 5.02e-05 CGCTTGGAGG AGGAGCTG G chr2:74688688-74688768 19 5.02e-05 TGGCCATAAA AGGAGCTG GAGGCTGCAA chr1:246810570-246810650 15 5.02e-05 GACCACATGG AGGAGCTG CTCTGCAGCG chr1:165740531-165740611 10 5.76e-05 tacaaaaaa attagctg gtcgtggtgg chr4:83809683-83809763 10 5.76e-05 aatacaaaa attagctg cgcgtgatgg chr19:42348894-42348974 58 7.01e-05 TTGTGCGCCA AGAAGCTG GCAGAAGGGA chr14:106947983-10694806 59 7.01e-05 gcatcttccc agaagctg gtgttaccgc chr1:153770050-153770130 51 8.87e-05 cagcctcccg cgtagctg ggactacagg chr7:23502080-23502160 27 8.87e-05 cagcctaccg cgtagctg ggactaaagg chr10:21881463-21881543 49 8.87e-05 cagcctcccg cgtagctg ggactacagg chr20:31123266-31123346 17 8.87e-05 ACTGTTAGCG CGTAGCTG CCGCCGCCAC chr3:141564406-141564486 27 1.07e-04 TGACTAGAGA AGTGGCTG GCAGCACCCC chr1:246737447-246737527 23 1.07e-04 cagcctccgg agtggctg ggactacagg chr8:130871739-130871819 10 1.25e-04 agtctgcta agtagcgg gtgtttttcc -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTAGCTG MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:29256116-29256196 1.2e-05 53_[+4]_19 chr15:66080501-66080581 1.2e-05 39_[+4]_33 chr5:131087798-131087878 1.2e-05 64_[+4]_8 chr1:8879016-8879096 1.2e-05 68_[+4]_4 chr6:106769324-106769404 1.2e-05 35_[+4]_37 chr21:15906907-15906987 1.2e-05 55_[+4]_17 chr1:180470543-180470623 1.2e-05 45_[+4]_27 chr1:155660753-155660833 1.2e-05 71_[+4]_1 chr3:5231355-5231435 1.2e-05 56_[+4]_16 chr6:27527398-27527478 1.2e-05 66_[+4]_6 chr10:98594727-98594807 1.2e-05 56_[+4]_16 chr12:93678232-93678312 1.2e-05 60_[+4]_12 chr11:107897909-10789798 1.2e-05 53_[+4]_19 chrX:47666158-47666238 1.2e-05 59_[+4]_13 chr1:180024785-180024865 1.2e-05 22_[+4]_50 chr16:88679832-88679912 3.1e-05 10_[+4]_62 chr7:150013635-150013715 3.1e-05 65_[+4]_7 chr19:40741725-40741805 3.1e-05 28_[+4]_44 chr10:3135932-3136012 3.1e-05 29_[+4]_43 chr4:109052212-109052292 3.1e-05 44_[+4]_28 chr6:47412111-47412191 5e-05 49_[+4]_23 chr18:77742864-77742944 5e-05 71_[+4]_1 chr2:74688688-74688768 5e-05 18_[+4]_54 chr1:246810570-246810650 5e-05 14_[+4]_58 chr1:165740531-165740611 5.8e-05 9_[+4]_63 chr4:83809683-83809763 5.8e-05 9_[+4]_63 chr19:42348894-42348974 7e-05 57_[+4]_15 chr14:106947983-10694806 7e-05 58_[+4]_14 chr1:153770050-153770130 8.9e-05 50_[+4]_22 chr7:23502080-23502160 8.9e-05 26_[+4]_46 chr10:21881463-21881543 8.9e-05 48_[+4]_24 chr20:31123266-31123346 8.9e-05 16_[+4]_56 chr3:141564406-141564486 0.00011 26_[+4]_46 chr1:246737447-246737527 0.00011 22_[+4]_50 chr8:130871739-130871819 0.00013 9_[+4]_63 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTAGCTG MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AGTAGCTG width=8 seqs=35 chr1:29256116-29256196 ( 54) AGTAGCTG 1 chr15:66080501-66080581 ( 40) AGTAGCTG 1 chr5:131087798-131087878 ( 65) AGTAGCTG 1 chr1:8879016-8879096 ( 69) AGTAGCTG 1 chr6:106769324-106769404 ( 36) AGTAGCTG 1 chr21:15906907-15906987 ( 56) AGTAGCTG 1 chr1:180470543-180470623 ( 46) AGTAGCTG 1 chr1:155660753-155660833 ( 72) AGTAGCTG 1 chr3:5231355-5231435 ( 57) AGTAGCTG 1 chr6:27527398-27527478 ( 67) AGTAGCTG 1 chr10:98594727-98594807 ( 57) AGTAGCTG 1 chr12:93678232-93678312 ( 61) AGTAGCTG 1 chr11:107897909-10789798 ( 54) AGTAGCTG 1 chrX:47666158-47666238 ( 60) AGTAGCTG 1 chr1:180024785-180024865 ( 23) AGTAGCTG 1 chr16:88679832-88679912 ( 11) AGCAGCTG 1 chr7:150013635-150013715 ( 66) AGCAGCTG 1 chr19:40741725-40741805 ( 29) AGCAGCTG 1 chr10:3135932-3136012 ( 30) AGCAGCTG 1 chr4:109052212-109052292 ( 45) AGCAGCTG 1 chr6:47412111-47412191 ( 50) AGGAGCTG 1 chr18:77742864-77742944 ( 72) AGGAGCTG 1 chr2:74688688-74688768 ( 19) AGGAGCTG 1 chr1:246810570-246810650 ( 15) AGGAGCTG 1 chr1:165740531-165740611 ( 10) ATTAGCTG 1 chr4:83809683-83809763 ( 10) ATTAGCTG 1 chr19:42348894-42348974 ( 58) AGAAGCTG 1 chr14:106947983-10694806 ( 59) AGAAGCTG 1 chr1:153770050-153770130 ( 51) CGTAGCTG 1 chr7:23502080-23502160 ( 27) CGTAGCTG 1 chr10:21881463-21881543 ( 49) CGTAGCTG 1 chr20:31123266-31123346 ( 17) CGTAGCTG 1 chr3:141564406-141564486 ( 27) AGTGGCTG 1 chr1:246737447-246737527 ( 23) AGTGGCTG 1 chr8:130871739-130871819 ( 10) AGTAGCGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTAGCTG MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.84661 E= 3.0e-017 216 -145 -1177 -1177 -1177 -1177 166 -173 -180 -113 -139 186 225 -1177 -238 -1177 -1177 -1177 174 -1177 -1177 168 -1177 -1177 -1177 -1177 -338 236 -1177 -1177 174 -1177 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTAGCTG MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 35 E= 3.0e-017 0.885714 0.114286 0.000000 0.000000 0.000000 0.000000 0.942857 0.057143 0.057143 0.142857 0.114286 0.685714 0.942857 0.000000 0.057143 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.028571 0.971429 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGTAGCTG MEME-4 regular expression -------------------------------------------------------------------------------- AGTAGCTG -------------------------------------------------------------------------------- Time 15.70 secs. ******************************************************************************** ******************************************************************************** MOTIF AGGCTGAG MEME-5 width = 8 sites = 23 llr = 236 E-value = 1.2e-013 ******************************************************************************** -------------------------------------------------------------------------------- Motif AGGCTGAG MEME-5 Description -------------------------------------------------------------------------------- Simplified A a:::1:9: pos.-specific C :::a::1: probability G :aa::a:a matrix T ::::9::: bits 2.4 * 2.2 * 1.9 * * * 1.7 ******** Relative 1.4 ******** Entropy 1.2 ******** (14.8 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AGGCTGAG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCTGAG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:40647989-40648069 13 1.87e-05 gctacttagg aggctgag gcaggagagt chr12:125421909-12542198 11 1.87e-05 gctactaggg aggctgag ccaggagaat chr1:179874371-179874451 35 1.87e-05 gctactcggg aggctgag gcagaagaat chr6:3159517-3159597 23 1.87e-05 gctactcggg aggctgag gcaggagaat chr6:134285043-134285123 32 1.87e-05 gctactcggg aggctgag gcgggagaat chr1:180577868-180577948 32 1.87e-05 gctacgcggg aggctgag gcgggagaat chr6:52157020-52157100 72 1.87e-05 gctactcgcg aggctgag g chr6:17947949-17948029 19 1.87e-05 gctactcaag aggctgag gcaggagaat chr20:46242385-46242465 33 1.87e-05 gcactttggg aggctgag gccggtggat chr15:91567112-91567192 1 1.87e-05 . aggctgag gcaggaggat chr15:76601628-76601708 60 1.87e-05 gctactcagg aggctgag gcaggagaat chr1:165740531-165740611 56 1.87e-05 gctactcggg aggctgag gcaggagaat chr1:29325741-29325821 37 1.87e-05 gctacttggg aggctgag gcaggagaat chr17:66018828-66018908 3 1.87e-05 gg aggctgag gcaggagaac chr7:138789294-138789374 71 1.87e-05 gctacgcggg aggctgag gc chr9:127939546-127939626 3 1.87e-05 aa aggctgag gcaggagaat chr16:30568329-30568409 28 1.87e-05 gctactgggg aggctgag gcgggagaat chr3:176862389-176862469 48 1.87e-05 agctactcag aggctgag gcaggagaat chr12:123942292-12394237 42 1.87e-05 gctacgcggg aggctgag gcaggaaaat chr5:61600917-61600997 27 3.84e-05 tgaacacagg aggcagag attgcagtga chr3:19999056-19999136 27 3.84e-05 tgaacctggg aggcagag gttgcagtga chr19:46232051-46232131 60 6.79e-05 aaaaataaaa aggctgcg cgcagtggct chr22:21062153-21062233 18 6.79e-05 GGCGTTACCA AGGCTGCG CCACCCACGT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCTGAG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:40647989-40648069 1.9e-05 12_[+5]_60 chr12:125421909-12542198 1.9e-05 10_[+5]_62 chr1:179874371-179874451 1.9e-05 34_[+5]_38 chr6:3159517-3159597 1.9e-05 22_[+5]_50 chr6:134285043-134285123 1.9e-05 31_[+5]_41 chr1:180577868-180577948 1.9e-05 31_[+5]_41 chr6:52157020-52157100 1.9e-05 71_[+5]_1 chr6:17947949-17948029 1.9e-05 18_[+5]_54 chr20:46242385-46242465 1.9e-05 32_[+5]_40 chr15:91567112-91567192 1.9e-05 [+5]_72 chr15:76601628-76601708 1.9e-05 59_[+5]_13 chr1:165740531-165740611 1.9e-05 55_[+5]_17 chr1:29325741-29325821 1.9e-05 36_[+5]_36 chr17:66018828-66018908 1.9e-05 2_[+5]_70 chr7:138789294-138789374 1.9e-05 70_[+5]_2 chr9:127939546-127939626 1.9e-05 2_[+5]_70 chr16:30568329-30568409 1.9e-05 27_[+5]_45 chr3:176862389-176862469 1.9e-05 47_[+5]_25 chr12:123942292-12394237 1.9e-05 41_[+5]_31 chr5:61600917-61600997 3.8e-05 26_[+5]_46 chr3:19999056-19999136 3.8e-05 26_[+5]_46 chr19:46232051-46232131 6.8e-05 59_[+5]_13 chr22:21062153-21062233 6.8e-05 17_[+5]_55 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCTGAG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AGGCTGAG width=8 seqs=23 chr1:40647989-40648069 ( 13) AGGCTGAG 1 chr12:125421909-12542198 ( 11) AGGCTGAG 1 chr1:179874371-179874451 ( 35) AGGCTGAG 1 chr6:3159517-3159597 ( 23) AGGCTGAG 1 chr6:134285043-134285123 ( 32) AGGCTGAG 1 chr1:180577868-180577948 ( 32) AGGCTGAG 1 chr6:52157020-52157100 ( 72) AGGCTGAG 1 chr6:17947949-17948029 ( 19) AGGCTGAG 1 chr20:46242385-46242465 ( 33) AGGCTGAG 1 chr15:91567112-91567192 ( 1) AGGCTGAG 1 chr15:76601628-76601708 ( 60) AGGCTGAG 1 chr1:165740531-165740611 ( 56) AGGCTGAG 1 chr1:29325741-29325821 ( 37) AGGCTGAG 1 chr17:66018828-66018908 ( 3) AGGCTGAG 1 chr7:138789294-138789374 ( 71) AGGCTGAG 1 chr9:127939546-127939626 ( 3) AGGCTGAG 1 chr16:30568329-30568409 ( 28) AGGCTGAG 1 chr3:176862389-176862469 ( 48) AGGCTGAG 1 chr12:123942292-12394237 ( 42) AGGCTGAG 1 chr5:61600917-61600997 ( 27) AGGCAGAG 1 chr3:19999056-19999136 ( 27) AGGCAGAG 1 chr19:46232051-46232131 ( 60) AGGCTGCG 1 chr22:21062153-21062233 ( 18) AGGCTGCG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCTGAG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.23674 E= 1.2e-013 233 -1117 -1117 -1117 -1117 -1117 174 -1117 -1117 -1117 174 -1117 -1117 167 -1117 -1117 -119 -1117 -1117 227 -1117 -1117 174 -1117 220 -185 -1117 -1117 -1117 -1117 174 -1117 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCTGAG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 23 E= 1.2e-013 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.086957 0.000000 0.000000 0.913043 0.000000 0.000000 1.000000 0.000000 0.913043 0.086957 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCTGAG MEME-5 regular expression -------------------------------------------------------------------------------- AGGCTGAG -------------------------------------------------------------------------------- Time 19.06 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:100231579-100231659 1.14e-02 21_[+1(4.28e-05)]_51 chr12:133387244-13338732 5.53e-02 80 chr3:46965132-46965212 2.09e-03 15_[+3(9.04e-05)]_57 chr19:10939779-10939859 1.46e-01 80 chr6:15512601-15512681 2.93e-01 80 chr1:25828385-25828465 6.21e-01 80 chr20:34274950-34275030 5.10e-02 80 chr20:62427636-62427716 2.90e-01 80 chr9:132630169-132630249 9.60e-02 80 chr11:68657738-68657818 5.23e-01 80 chr5:1599285-1599365 7.54e-01 80 chr14:21558586-21558666 8.12e-01 80 chr16:4311731-4311811 1.08e-01 80 chr20:62245737-62245817 8.85e-02 80 chr11:57080018-57080098 2.64e-01 80 chr19:32868131-32868211 1.67e-01 80 chr5:115422171-115422251 2.12e-02 62_[+2(5.42e-05)]_10 chr7:2139990-2140070 2.18e-02 80 chr9:131641707-131641787 8.36e-01 80 chr6:14397571-14397651 5.90e-02 39_[+5(9.89e-05)]_33 chr5:156751382-156751462 3.67e-01 80 chr14:103763416-10376349 5.32e-03 [+1(2.09e-05)]_72 chr4:1914947-1915027 4.76e-01 80 chr1:38494916-38494996 8.54e-03 58_[+5(9.89e-05)]_14 chr12:49677970-49678050 2.31e-01 80 chr9:139870181-139870261 1.11e-01 80 chr6:44195308-44195388 6.01e-02 80 chr22:21062153-21062233 9.54e-02 17_[+5(6.79e-05)]_55 chr12:123942292-12394237 1.56e-02 41_[+5(1.87e-05)]_31 chr3:38204745-38204825 2.16e-01 80 chr6:31810437-31810517 2.13e-02 80 chr8:144397158-144397238 2.72e-01 80 chr22:18263807-18263887 5.65e-01 80 chr1:226158605-226158685 8.44e-02 80 chr9:131410630-131410710 6.24e-02 80 chr11:64528038-64528118 2.41e-01 80 chr7:99013275-99013355 3.93e-01 80 chr4:109052212-109052292 1.18e-04 44_[+4(3.14e-05)]_1_[+1(2.09e-05)]_\ 19 chrX:49013647-49013727 6.41e-01 80 chr9:133567881-133567961 1.80e-01 80 chr1:180024785-180024865 6.37e-08 [+3(7.79e-06)]_4_[+2(5.42e-05)]_2_\ [+4(1.18e-05)]_1_[+1(2.09e-05)]_41 chr11:74851723-74851803 8.25e-02 80 chrX:47666158-47666238 3.67e-02 59_[+4(1.18e-05)]_13 chr16:2550768-2550848 2.63e-01 80 chr1:246810570-246810650 9.65e-02 14_[+4(5.02e-05)]_58 chr1:198668743-198668823 2.03e-01 80 chr14:106947983-10694806 4.39e-02 58_[+4(7.01e-05)]_14 chr9:132481562-132481642 2.80e-01 80 chr20:31123266-31123346 7.46e-02 16_[+4(8.87e-05)]_56 chr19:628355-628435 2.09e-01 80 chr1:246737447-246737527 2.95e-06 12_[+2(5.42e-05)]_11_[+1(2.09e-05)]_\ 41 chr2:10933297-10933377 3.32e-01 80 chr11:107897909-10789798 1.07e-03 53_[+4(1.18e-05)]_19 chr16:85083615-85083695 3.46e-01 80 chr16:30989082-30989162 2.71e-01 80 chr10:3135932-3136012 1.57e-06 19_[+2(5.42e-05)]_2_[+4(3.14e-05)]_\ 1_[+1(2.09e-05)]_34 chr1:10590459-10590539 3.17e-01 80 chr3:176862389-176862469 2.98e-04 47_[+5(1.87e-05)]_25 chr1:41583041-41583121 2.86e-01 80 chr10:1156107-1156187 1.16e-01 80 chr16:2655500-2655580 7.38e-01 80 chr2:44125572-44125652 4.87e-01 80 chr1:173532118-173532198 3.40e-01 80 chr19:13915697-13915777 1.26e-01 80 chr12:132536426-13253650 7.04e-01 80 chr13:114275976-11427605 2.55e-01 80 chr9:130839506-130839586 5.64e-01 80 chr19:50416739-50416819 3.62e-01 80 chr16:30568329-30568409 5.58e-03 27_[+5(1.87e-05)]_45 chr15:96897208-96897288 3.83e-01 80 chr2:170681873-170681953 1.28e-01 80 chr17:40431469-40431549 7.25e-02 80 chr12:93678232-93678312 1.72e-08 38_[+3(7.79e-06)]_4_[+2(5.42e-05)]_\ 2_[+4(1.18e-05)]_1_[+1(2.09e-05)]_3 chr2:153611691-153611771 7.08e-02 80 chr1:33235891-33235971 3.92e-02 80 chr7:148769087-148769167 3.92e-02 17_[+2(8.69e-05)]_55 chr11:116765921-11676600 1.63e-01 80 chr8:141348940-141349020 9.86e-02 80 chr19:10463477-10463557 1.89e-01 80 chr10:98594727-98594807 2.72e-06 46_[+2(5.42e-05)]_2_[+4(1.18e-05)]_\ 1_[+1(2.09e-05)]_7 chr21:47602631-47602711 1.25e-03 15_[+3(7.79e-06)]_57 chr4:127872579-127872659 7.59e-03 [+1(2.09e-05)]_72 chr19:19014074-19014154 2.10e-01 80 chr17:46711529-46711609 4.61e-01 80 chr17:27944239-27944319 6.98e-01 80 chr19:38942418-38942498 6.60e-01 80 chr7:157198827-157198907 8.78e-01 80 chr10:21881463-21881543 2.23e-07 26_[+3(7.79e-06)]_4_[+2(5.42e-05)]_\ 2_[+4(8.87e-05)]_1_[+1(2.09e-05)]_15 chr5:179228905-179228985 6.32e-01 80 chr6:27139705-27139785 7.90e-01 80 chr1:246724303-246724383 6.31e-01 80 chr9:127939546-127939626 2.29e-03 2_[+5(1.87e-05)]_70 chr6:27527398-27527478 7.62e-06 44_[+3(7.79e-06)]_4_[+2(5.42e-05)]_\ 2_[+4(1.18e-05)]_6 chr16:18813857-18813937 2.28e-02 19_[+1(2.09e-05)]_53 chr8:145792769-145792849 2.37e-01 80 chr22:49909337-49909417 3.46e-01 80 chr7:138789294-138789374 4.99e-02 70_[+5(1.87e-05)]_2 chr19:40741725-40741805 1.06e-02 28_[+4(3.14e-05)]_44 chr9:135916508-135916588 5.50e-01 80 chr17:37071351-37071431 3.67e-01 80 chr1:51852079-51852159 5.18e-01 80 chr6:170097391-170097471 9.05e-03 80 chr16:28961578-28961658 4.18e-02 6_[+1(2.09e-05)]_66 chr19:7067278-7067358 1.86e-01 80 chr16:2007499-2007579 5.08e-01 80 chr16:84637000-84637080 9.32e-01 80 chr9:140453795-140453875 2.86e-01 80 chr6:171021965-171022045 3.02e-01 80 chr9:130943918-130943998 1.23e-01 80 chr7:38787785-38787865 9.77e-01 80 chr14:77505105-77505185 1.22e-01 80 chr7:23502080-23502160 3.40e-05 4_[+3(7.79e-06)]_14_[+4(8.87e-05)]_\ 46 chr4:74537188-74537268 2.43e-01 80 chr9:130732418-130732498 8.79e-02 52_[+2(5.42e-05)]_20 chr1:8458878-8458958 1.08e-01 80 chr16:85391673-85391753 6.86e-02 80 chr20:62204387-62204467 5.69e-01 80 chr7:98719350-98719430 7.23e-01 80 chr16:87891836-87891916 3.64e-01 80 chr9:131107397-131107477 5.21e-02 80 chr7:151094746-151094826 4.82e-01 80 chr19:55783661-55783741 3.62e-01 80 chr15:101810191-10181027 1.97e-02 63_[+2(5.42e-05)]_9 chr10:76844884-76844964 5.27e-02 13_[+5(9.89e-05)]_59 chr6:43966749-43966829 1.89e-01 80 chr17:66018828-66018908 4.21e-03 2_[+5(1.87e-05)]_70 chr6:17817295-17817375 1.43e-01 80 chr4:83809683-83809763 1.52e-03 9_[+4(5.76e-05)]_63 chr6:26272546-26272626 6.44e-02 80 chr10:30721711-30721791 2.99e-03 37_[+1(2.09e-05)]_35 chr1:171729933-171730013 2.00e-01 80 chr1:29325741-29325821 5.73e-03 36_[+5(1.87e-05)]_36 chr3:5231355-5231435 6.37e-08 34_[+3(7.79e-06)]_4_[+2(5.42e-05)]_\ 2_[+4(1.18e-05)]_1_[+1(2.09e-05)]_7 chr3:141564406-141564486 5.73e-04 80 chr1:155660753-155660833 5.74e-06 49_[+3(7.79e-06)]_4_[+2(5.42e-05)]_\ 2_[+4(1.18e-05)]_1 chr10:69523355-69523435 2.79e-01 80 chr2:74688688-74688768 1.31e-02 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chr7:2138799-2138879 1.39e-01 80 chr6:47412111-47412191 9.24e-02 49_[+4(5.02e-05)]_23 chr1:27873839-27873919 3.64e-01 80 chr1:78384742-78384822 3.81e-01 80 chr1:235466303-235466383 1.72e-06 39_[+3(7.79e-06)]_4_[+2(5.42e-05)]_\ 11_[+1(2.09e-05)]_2 chr1:40647989-40648069 3.39e-04 12_[+5(1.87e-05)]_60 chr22:29709276-29709356 5.49e-01 80 chr6:28955625-28955705 1.82e-01 80 chr17:80841082-80841162 7.21e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n05.farnam.hpc.yale.internal ********************************************************************************