******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/XRCC3.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr4:436701-436781 1.0000 80 chr19:12016887-12016967 1.0000 80 chr1:247150568-247150648 1.0000 80 chr7:149229853-149229933 1.0000 80 chr12:31761366-31761446 1.0000 80 chr11:2681742-2681822 1.0000 80 chr1:228432859-228432939 1.0000 80 chr19:11944505-11944585 1.0000 80 chr10:44020004-44020084 1.0000 80 chr19:52618923-52619003 1.0000 80 chr19:39426189-39426269 1.0000 80 chr7:33158154-33158234 1.0000 80 chr7:66541266-66541346 1.0000 80 chr10:42831534-42831614 1.0000 80 chr17:18565408-18565488 1.0000 80 chr10:43088903-43088983 1.0000 80 chr6:16031046-16031126 1.0000 80 chr9:123570058-123570138 1.0000 80 chr15:28554071-28554151 1.0000 80 chr11:47897566-47897646 1.0000 80 chr7:151735630-151735710 1.0000 80 chr7:5104703-5104783 1.0000 80 chr4:435635-435715 1.0000 80 chr2:198348421-198348501 1.0000 80 chr7:72200984-72201064 1.0000 80 chr3:138592925-138593005 1.0000 80 chrX:2793191-2793271 1.0000 80 chr7:111370281-111370361 1.0000 80 chr6:109512782-109512862 1.0000 80 chr7:99138343-99138423 1.0000 80 chr17:15620379-15620459 1.0000 80 chr3:194255135-194255215 1.0000 80 chr10:42832612-42832692 1.0000 80 chr2:170429413-170429493 1.0000 80 chr20:55096191-55096271 1.0000 80 chr12:131341895-13134197 1.0000 80 chr10:47539342-47539422 1.0000 80 chr12:807567-807647 1.0000 80 chr9:95609031-95609111 1.0000 80 chr10:49685303-49685383 1.0000 80 chr1:247193039-247193119 1.0000 80 chr8:86973134-86973214 1.0000 80 chr12:50886017-50886097 1.0000 80 chr17:45142199-45142279 1.0000 80 chr7:23515334-23515414 1.0000 80 chr22:22485278-22485358 1.0000 80 chr7:12761989-12762069 1.0000 80 chr19:12187332-12187412 1.0000 80 chr19:35408221-35408301 1.0000 80 chr6:28936669-28936749 1.0000 80 chr6:111243872-111243952 1.0000 80 chr8:125924017-125924097 1.0000 80 chr19:11917747-11917827 1.0000 80 chr8:146107473-146107553 1.0000 80 chr17:44999921-45000001 1.0000 80 chr10:62737545-62737625 1.0000 80 chr6:109613826-109613906 1.0000 80 chr19:16332116-16332196 1.0000 80 chr12:133780923-13378100 1.0000 80 chr20:60650972-60651052 1.0000 80 chr1:36106091-36106171 1.0000 80 chr1:247320221-247320301 1.0000 80 chr7:56220632-56220712 1.0000 80 chrX:2756223-2756303 1.0000 80 chr19:37038278-37038358 1.0000 80 chr7:106304171-106304251 1.0000 80 chr13:90574389-90574469 1.0000 80 chr1:117409247-117409327 1.0000 80 chr7:149395063-149395143 1.0000 80 chr1:142802557-142802637 1.0000 80 chr17:29965640-29965720 1.0000 80 chr3:139024919-139024999 1.0000 80 chr4:437279-437359 1.0000 80 chr11:3317588-3317668 1.0000 80 chr4:80127974-80128054 1.0000 80 chr7:138030447-138030527 1.0000 80 chr16:31554225-31554305 1.0000 80 chr1:114905970-114906050 1.0000 80 chr14:91667318-91667398 1.0000 80 chr9:104171386-104171466 1.0000 80 chr19:9868267-9868347 1.0000 80 chr21:34036559-34036639 1.0000 80 chr19:9634757-9634837 1.0000 80 chr7:141279965-141280045 1.0000 80 chr7:148733923-148734003 1.0000 80 chr13:21139668-21139748 1.0000 80 chr5:34782150-34782230 1.0000 80 chr10:104970100-10497018 1.0000 80 chr7:110656151-110656231 1.0000 80 chr18:9424413-9424493 1.0000 80 chr1:30565474-30565554 1.0000 80 chr19:12060681-12060761 1.0000 80 chr1:228431692-228431772 1.0000 80 chrX:134421350-134421430 1.0000 80 chr6:28963237-28963317 1.0000 80 chr13:91726852-91726932 1.0000 80 chr22:23211184-23211264 1.0000 80 chr19:58132275-58132355 1.0000 80 chr1:225967393-225967473 1.0000 80 chr13:91287380-91287460 1.0000 80 chr12:104628857-10462893 1.0000 80 chr3:13220819-13220899 1.0000 80 chr1:166674254-166674334 1.0000 80 chr7:6730807-6730887 1.0000 80 chr1:23348438-23348518 1.0000 80 chr8:144732731-144732811 1.0000 80 chr15:93493014-93493094 1.0000 80 chr13:91860001-91860081 1.0000 80 chr2:48615854-48615934 1.0000 80 chr8:130581873-130581953 1.0000 80 chr7:152402018-152402098 1.0000 80 chr10:17304681-17304761 1.0000 80 chr10:47541063-47541143 1.0000 80 chr18:23854129-23854209 1.0000 80 chr1:147149960-147150040 1.0000 80 chr7:106122205-106122285 1.0000 80 chr22:41611615-41611695 1.0000 80 chr1:28836087-28836167 1.0000 80 chr13:92130450-92130530 1.0000 80 chr12:124653718-12465379 1.0000 80 chr8:37880118-37880198 1.0000 80 chr19:2917500-2917580 1.0000 80 chr9:123566701-123566781 1.0000 80 chr22:18968512-18968592 1.0000 80 chr6:28156060-28156140 1.0000 80 chr5:42988803-42988883 1.0000 80 chr22:42500515-42500595 1.0000 80 chr4:1740314-1740394 1.0000 80 chr1:23349779-23349859 1.0000 80 chr12:53575858-53575938 1.0000 80 chr5:150211601-150211681 1.0000 80 chr6:35611586-35611666 1.0000 80 chr2:112866969-112867049 1.0000 80 chr7:135949178-135949258 1.0000 80 chr6:137491198-137491278 1.0000 80 chr5:150311124-150311204 1.0000 80 chr1:204492902-204492982 1.0000 80 chr15:60568013-60568093 1.0000 80 chr8:146202715-146202795 1.0000 80 chr20:52207325-52207405 1.0000 80 chr1:180557406-180557486 1.0000 80 chr3:183161674-183161754 1.0000 80 chr1:25962808-25962888 1.0000 80 chr15:68577141-68577221 1.0000 80 chr7:130016482-130016562 1.0000 80 chr4:38257305-38257385 1.0000 80 chr17:80698887-80698967 1.0000 80 chr18:11957067-11957147 1.0000 80 chr1:46859244-46859324 1.0000 80 chr12:133779267-13377934 1.0000 80 chr18:19773691-19773771 1.0000 80 chr6:135805206-135805286 1.0000 80 chr7:66189123-66189203 1.0000 80 chr2:95815308-95815388 1.0000 80 chr1:24205312-24205392 1.0000 80 chr22:22798156-22798236 1.0000 80 chr3:196483748-196483828 1.0000 80 chr1:54308166-54308246 1.0000 80 chr7:5060914-5060994 1.0000 80 chr20:29633372-29633452 1.0000 80 chr8:86970377-86970457 1.0000 80 chr7:129217979-129218059 1.0000 80 chr19:12138165-12138245 1.0000 80 chr19:12637502-12637582 1.0000 80 chr17:37203395-37203475 1.0000 80 chr6:27420425-27420505 1.0000 80 chr15:43653643-43653723 1.0000 80 chr10:70231065-70231145 1.0000 80 chr2:238871259-238871339 1.0000 80 chr16:10588948-10589028 1.0000 80 chr12:127643592-12764367 1.0000 80 chr7:138017737-138017817 1.0000 80 chr1:20486697-20486777 1.0000 80 chr3:42956494-42956574 1.0000 80 chr17:48477189-48477269 1.0000 80 chr1:1348055-1348135 1.0000 80 chr3:33773949-33774029 1.0000 80 chr2:46486197-46486277 1.0000 80 chr10:52320599-52320679 1.0000 80 chr4:129186890-129186970 1.0000 80 chr19:53471215-53471295 1.0000 80 chr12:96738210-96738290 1.0000 80 chr7:65926556-65926636 1.0000 80 chr15:85164768-85164848 1.0000 80 chr17:75170842-75170922 1.0000 80 chr8:30004983-30005063 1.0000 80 chr9:123567280-123567360 1.0000 80 chr21:44420364-44420444 1.0000 80 chr22:38768858-38768938 1.0000 80 chr1:117286304-117286384 1.0000 80 chr11:33953419-33953499 1.0000 80 chr22:17132256-17132336 1.0000 80 chr9:45699258-45699338 1.0000 80 chr12:57303390-57303470 1.0000 80 chr3:10287166-10287246 1.0000 80 chr1:16919472-16919552 1.0000 80 chr1:205125243-205125323 1.0000 80 chr16:70885265-70885345 1.0000 80 chr6:35397397-35397477 1.0000 80 chr19:44514777-44514857 1.0000 80 chr4:72729355-72729435 1.0000 80 chr6:161645783-161645863 1.0000 80 chr11:63559430-63559510 1.0000 80 chr5:171406732-171406812 1.0000 80 chr15:43420808-43420888 1.0000 80 chr7:107515624-107515704 1.0000 80 chr7:149408033-149408113 1.0000 80 chr9:99581032-99581112 1.0000 80 chr7:152430498-152430578 1.0000 80 chr2:55294185-55294265 1.0000 80 chr1:31931290-31931370 1.0000 80 chr19:9752602-9752682 1.0000 80 chr7:149297601-149297681 1.0000 80 chr1:228430134-228430214 1.0000 80 chr19:12053698-12053778 1.0000 80 chr22:23074568-23074648 1.0000 80 chr1:40928931-40929011 1.0000 80 chr7:159120923-159121003 1.0000 80 chr3:44683902-44683982 1.0000 80 chr7:106706427-106706507 1.0000 80 chr10:73715400-73715480 1.0000 80 chr7:106645520-106645600 1.0000 80 chr1:63109222-63109302 1.0000 80 chr7:156513681-156513761 1.0000 80 chr16:3274045-3274125 1.0000 80 chr19:35668434-35668514 1.0000 80 chr13:90449786-90449866 1.0000 80 chr2:122440528-122440608 1.0000 80 chr8:195497-195577 1.0000 80 chr3:48655171-48655251 1.0000 80 chr1:15168614-15168694 1.0000 80 chr16:72707205-72707285 1.0000 80 chr15:80208269-80208349 1.0000 80 chr1:46704678-46704758 1.0000 80 chr2:171780436-171780516 1.0000 80 chr22:25112709-25112789 1.0000 80 chr6:135803053-135803133 1.0000 80 chr1:160955643-160955723 1.0000 80 chr19:14829501-14829581 1.0000 80 chr1:16871889-16871969 1.0000 80 chr1:211867403-211867483 1.0000 80 chr6:30837191-30837271 1.0000 80 chr9:115759549-115759629 1.0000 80 chr19:44536386-44536466 1.0000 80 chr1:244739764-244739844 1.0000 80 chr16:89064293-89064373 1.0000 80 chr6:27111203-27111283 1.0000 80 chr15:80212641-80212721 1.0000 80 chr3:143276964-143277044 1.0000 80 chr1:1467470-1467550 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_XRCC3/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/XRCC3.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.296 C 0.202 G 0.207 T 0.296 Background letter frequencies (from file dataset with add-one prior applied): A 0.296 C 0.202 G 0.207 T 0.296 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TTCTGCAG MEME-1 width = 8 sites = 65 llr = 580 E-value = 3.2e-052 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 Description -------------------------------------------------------------------------------- Simplified A ::::::a: pos.-specific C 2:9:2a:: probability G :1::8::a matrix T 891a:::: bits 2.3 2.1 * * 1.8 * * * 1.6 ** * * Relative 1.4 ******* Entropy 1.2 ******** (12.9 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTCTGCAG consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:244739764-244739844 31 1.34e-05 ggagcatcct ttctgcag aaagtacaat chr22:25112709-25112789 39 1.34e-05 tgagcactgt ttctgcag aaaataaaaa chr15:80208269-80208349 46 1.34e-05 caattttact ttctgcag aaagggtgct chr3:48655171-48655251 36 1.34e-05 caaatttact ttctgcag aaagggtgct chr2:122440528-122440608 45 1.34e-05 aatttttact ttctgcag aaagggtgct chr1:31931290-31931370 33 1.34e-05 gtagcaccct ttctgcag aaagtaaaat chr7:152430498-152430578 43 1.34e-05 caattttact ttctgcag aaagggtgct chr5:171406732-171406812 54 1.34e-05 tttttctatt ttctgcag aaagggtaca chr6:35397397-35397477 34 1.34e-05 caattttact ttctgcag gaagggtgtt chr3:10287166-10287246 16 1.34e-05 agtgtaccct ttctgcag aaagtgtaaa chr2:238871259-238871339 19 1.34e-05 ctagtttagt ttctgcag aaagggtgcc chr17:37203395-37203475 32 1.34e-05 gaagcaccct ttctgcag aaagtaaatt chr1:180557406-180557486 39 1.34e-05 gggacaccct ttctgcag aaagtaaaaa chr4:1740314-1740394 30 1.34e-05 agtttttact ttctgcag aaagggtgcc chr22:42500515-42500595 25 1.34e-05 ggcaatttac ttctgcag aagggtgctg chr1:147149960-147150040 42 1.34e-05 catttttact ttctgcag aaagggtaca chr10:17304681-17304761 19 1.34e-05 ggagcaccct ttctgcag aaagtaaatt chr7:152402018-152402098 33 1.34e-05 gaagcaccct ttctgcag aaagtaaaaa chr15:93493014-93493094 28 1.34e-05 caattttact ttctgcag aaagggtgct chr12:104628857-10462893 30 1.34e-05 gcaaatttac ttctgcag aaaggtgctg chr1:30565474-30565554 32 1.34e-05 aatttttact ttctgcag aaagggtgct chr4:80127974-80128054 15 1.34e-05 agtgtaccct ttctgcag aaagtaaaaa chr19:16332116-16332196 31 1.34e-05 caaatttact ttctgcag aaagggtgct chr8:125924017-125924097 35 1.34e-05 tgagcaccct ttctgcag aaagtaaaga chr19:35408221-35408301 28 1.34e-05 tttttatgct ttctgcag aaagggtaca chr17:45142199-45142279 49 1.34e-05 catttttact ttctgcag aaagggtgct chr12:807567-807647 18 1.34e-05 agtgtaccct ttctgcag aaagtgaaaa chr3:138592925-138593005 64 1.34e-05 tgagcaccct ttctgcag aaagtaaag chr7:72200984-72201064 28 1.34e-05 tttttttact ttctgcag aaagggtaca chr2:198348421-198348501 37 1.34e-05 agtgtaccct ttctgcag aaagtaaaaa chr7:66541266-66541346 33 1.34e-05 agtgtaccct ttctgcag aaagtaaaaa chr19:12138165-12138245 38 2.26e-05 taaacaaaat ctctgcag cactgtgaca chr7:56220632-56220712 65 2.26e-05 taaacaaaat ctctgcag cactgtga chr6:27420425-27420505 4 3.57e-05 TTT TTCTCCAG TATGAATTCT chr2:95815308-95815388 67 4.46e-05 TGTAGGGTTT CTCTCCAG TGTGAA chr8:146202715-146202795 47 4.46e-05 TATAAGGTTT CTCTCCAG TGTGAATTCT chr4:437279-437359 71 4.46e-05 TGTAGGGTTT CTCTCCAG TA chr1:247320221-247320301 10 4.46e-05 ATAAGGTTT CTCTCCAG TGTGAGTTCT chr9:95609031-95609111 55 4.46e-05 TATAAGGTTT CTCTCCAG TGTGAATTTT chr10:42832612-42832692 39 4.46e-05 TGTAGGATTT CTCTCCAG TATGAGTTCT chr4:435635-435715 35 4.46e-05 TGTAGGGTTT CTCTCCAG TATGAATTCT chr10:42831534-42831614 33 4.46e-05 TGTAGGGTTT CTCTCCAG TATGATTTCT chr19:52618923-52619003 24 4.46e-05 TGTAAGGTTT CTCTCCAG TATGAATTCT chr1:205125243-205125323 16 5.40e-05 ggcagaagtt tgctgcag gggtggagcc chr7:148733923-148734003 11 5.40e-05 tttaattggg tgctgcag ctgaggagat chr8:146107473-146107553 40 5.40e-05 GATCCTCTGG TGCTGCAG CAGTGTCCTC chr19:39426189-39426269 53 5.40e-05 catgtcacag tgctgcag agattttgtt chr6:30837191-30837271 36 1.10e-04 tgccctggtc tcctgcag taccctcagg chr1:46704678-46704758 23 1.10e-04 gagagagagc ttgtgcag ggaaattccc chr15:43420808-43420888 64 1.10e-04 cgctctggtc tcctgcag taccctcag chr22:38768858-38768938 33 1.10e-04 agcctaaggt ttctgctg ggaaatcagc chr17:75170842-75170922 53 1.10e-04 ggcaatttac ttttgcag aagggtgccg chr6:135805206-135805286 38 1.10e-04 aagagagagc ttgtgcag ggaaactccc chr12:131341895-13134197 65 1.10e-04 gtgctatttc ttttgcag caccaaaa chr6:109512782-109512862 14 1.10e-04 ccttgctgct ttgtgcag tctcagaact chr6:16031046-16031126 58 1.10e-04 ttacctacca ttttgcag tcactgggct chr1:117286304-117286384 39 1.36e-04 ggcagcaccc ttctgcaa agtaaatgtg chr2:170429413-170429493 24 1.36e-04 AATctaatat ttctgcaa catgttacca chr11:2681742-2681822 70 1.36e-04 gaacaggcaa ttctgcaa gag chr7:138030447-138030527 31 1.93e-04 agctcggagg ctttgcag cctccacact chr7:149395063-149395143 69 1.93e-04 cagactggtt ctctgctg ttga chr12:96738210-96738290 45 2.28e-04 tatacatggg ctcttcag taagattaac chr7:99138343-99138423 71 2.28e-04 GGTGGAATTG CTCTTCAG TG chr19:9868267-9868347 61 3.03e-04 CATAAGGCTT TTCTCCTG TGTGCGTTCG chr1:20486697-20486777 60 3.78e-04 TGTCTCCTGT CTCTGAAG AGGAGGAGGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:244739764-244739844 1.3e-05 30_[+1]_42 chr22:25112709-25112789 1.3e-05 38_[+1]_34 chr15:80208269-80208349 1.3e-05 45_[+1]_27 chr3:48655171-48655251 1.3e-05 35_[+1]_37 chr2:122440528-122440608 1.3e-05 44_[+1]_28 chr1:31931290-31931370 1.3e-05 32_[+1]_40 chr7:152430498-152430578 1.3e-05 42_[+1]_30 chr5:171406732-171406812 1.3e-05 53_[+1]_19 chr6:35397397-35397477 1.3e-05 33_[+1]_39 chr3:10287166-10287246 1.3e-05 15_[+1]_57 chr2:238871259-238871339 1.3e-05 18_[+1]_54 chr17:37203395-37203475 1.3e-05 31_[+1]_41 chr1:180557406-180557486 1.3e-05 38_[+1]_34 chr4:1740314-1740394 1.3e-05 29_[+1]_43 chr22:42500515-42500595 1.3e-05 24_[+1]_48 chr1:147149960-147150040 1.3e-05 41_[+1]_31 chr10:17304681-17304761 1.3e-05 18_[+1]_54 chr7:152402018-152402098 1.3e-05 32_[+1]_40 chr15:93493014-93493094 1.3e-05 27_[+1]_45 chr12:104628857-10462893 1.3e-05 29_[+1]_43 chr1:30565474-30565554 1.3e-05 31_[+1]_41 chr4:80127974-80128054 1.3e-05 14_[+1]_58 chr19:16332116-16332196 1.3e-05 30_[+1]_42 chr8:125924017-125924097 1.3e-05 34_[+1]_38 chr19:35408221-35408301 1.3e-05 27_[+1]_45 chr17:45142199-45142279 1.3e-05 48_[+1]_24 chr12:807567-807647 1.3e-05 17_[+1]_55 chr3:138592925-138593005 1.3e-05 63_[+1]_9 chr7:72200984-72201064 1.3e-05 27_[+1]_45 chr2:198348421-198348501 1.3e-05 36_[+1]_36 chr7:66541266-66541346 1.3e-05 32_[+1]_40 chr19:12138165-12138245 2.3e-05 37_[+1]_35 chr7:56220632-56220712 2.3e-05 64_[+1]_8 chr6:27420425-27420505 3.6e-05 3_[+1]_69 chr2:95815308-95815388 4.5e-05 66_[+1]_6 chr8:146202715-146202795 4.5e-05 46_[+1]_26 chr4:437279-437359 4.5e-05 70_[+1]_2 chr1:247320221-247320301 4.5e-05 9_[+1]_63 chr9:95609031-95609111 4.5e-05 54_[+1]_18 chr10:42832612-42832692 4.5e-05 38_[+1]_34 chr4:435635-435715 4.5e-05 34_[+1]_38 chr10:42831534-42831614 4.5e-05 32_[+1]_40 chr19:52618923-52619003 4.5e-05 23_[+1]_49 chr1:205125243-205125323 5.4e-05 15_[+1]_57 chr7:148733923-148734003 5.4e-05 10_[+1]_62 chr8:146107473-146107553 5.4e-05 39_[+1]_33 chr19:39426189-39426269 5.4e-05 52_[+1]_20 chr6:30837191-30837271 0.00011 35_[+1]_37 chr1:46704678-46704758 0.00011 22_[+1]_50 chr15:43420808-43420888 0.00011 63_[+1]_9 chr22:38768858-38768938 0.00011 32_[+1]_40 chr17:75170842-75170922 0.00011 52_[+1]_20 chr6:135805206-135805286 0.00011 37_[+1]_35 chr12:131341895-13134197 0.00011 64_[+1]_8 chr6:109512782-109512862 0.00011 13_[+1]_59 chr6:16031046-16031126 0.00011 57_[+1]_15 chr1:117286304-117286384 0.00014 38_[+1]_34 chr2:170429413-170429493 0.00014 23_[+1]_49 chr11:2681742-2681822 0.00014 69_[+1]_3 chr7:138030447-138030527 0.00019 30_[+1]_42 chr7:149395063-149395143 0.00019 68_[+1]_4 chr12:96738210-96738290 0.00023 44_[+1]_28 chr7:99138343-99138423 0.00023 70_[+1]_2 chr19:9868267-9868347 0.0003 60_[+1]_12 chr1:20486697-20486777 0.00038 59_[+1]_13 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTCTGCAG width=8 seqs=65 chr1:244739764-244739844 ( 31) TTCTGCAG 1 chr22:25112709-25112789 ( 39) TTCTGCAG 1 chr15:80208269-80208349 ( 46) TTCTGCAG 1 chr3:48655171-48655251 ( 36) TTCTGCAG 1 chr2:122440528-122440608 ( 45) TTCTGCAG 1 chr1:31931290-31931370 ( 33) TTCTGCAG 1 chr7:152430498-152430578 ( 43) TTCTGCAG 1 chr5:171406732-171406812 ( 54) TTCTGCAG 1 chr6:35397397-35397477 ( 34) TTCTGCAG 1 chr3:10287166-10287246 ( 16) TTCTGCAG 1 chr2:238871259-238871339 ( 19) TTCTGCAG 1 chr17:37203395-37203475 ( 32) TTCTGCAG 1 chr1:180557406-180557486 ( 39) TTCTGCAG 1 chr4:1740314-1740394 ( 30) TTCTGCAG 1 chr22:42500515-42500595 ( 25) TTCTGCAG 1 chr1:147149960-147150040 ( 42) TTCTGCAG 1 chr10:17304681-17304761 ( 19) TTCTGCAG 1 chr7:152402018-152402098 ( 33) TTCTGCAG 1 chr15:93493014-93493094 ( 28) TTCTGCAG 1 chr12:104628857-10462893 ( 30) TTCTGCAG 1 chr1:30565474-30565554 ( 32) TTCTGCAG 1 chr4:80127974-80128054 ( 15) TTCTGCAG 1 chr19:16332116-16332196 ( 31) TTCTGCAG 1 chr8:125924017-125924097 ( 35) TTCTGCAG 1 chr19:35408221-35408301 ( 28) TTCTGCAG 1 chr17:45142199-45142279 ( 49) TTCTGCAG 1 chr12:807567-807647 ( 18) TTCTGCAG 1 chr3:138592925-138593005 ( 64) TTCTGCAG 1 chr7:72200984-72201064 ( 28) TTCTGCAG 1 chr2:198348421-198348501 ( 37) TTCTGCAG 1 chr7:66541266-66541346 ( 33) TTCTGCAG 1 chr19:12138165-12138245 ( 38) CTCTGCAG 1 chr7:56220632-56220712 ( 65) CTCTGCAG 1 chr6:27420425-27420505 ( 4) TTCTCCAG 1 chr2:95815308-95815388 ( 67) CTCTCCAG 1 chr8:146202715-146202795 ( 47) CTCTCCAG 1 chr4:437279-437359 ( 71) CTCTCCAG 1 chr1:247320221-247320301 ( 10) CTCTCCAG 1 chr9:95609031-95609111 ( 55) CTCTCCAG 1 chr10:42832612-42832692 ( 39) CTCTCCAG 1 chr4:435635-435715 ( 35) CTCTCCAG 1 chr10:42831534-42831614 ( 33) CTCTCCAG 1 chr19:52618923-52619003 ( 24) CTCTCCAG 1 chr1:205125243-205125323 ( 16) TGCTGCAG 1 chr7:148733923-148734003 ( 11) TGCTGCAG 1 chr8:146107473-146107553 ( 40) TGCTGCAG 1 chr19:39426189-39426269 ( 53) TGCTGCAG 1 chr6:30837191-30837271 ( 36) TCCTGCAG 1 chr1:46704678-46704758 ( 23) TTGTGCAG 1 chr15:43420808-43420888 ( 64) TCCTGCAG 1 chr22:38768858-38768938 ( 33) TTCTGCTG 1 chr17:75170842-75170922 ( 53) TTTTGCAG 1 chr6:135805206-135805286 ( 38) TTGTGCAG 1 chr12:131341895-13134197 ( 65) TTTTGCAG 1 chr6:109512782-109512862 ( 14) TTGTGCAG 1 chr6:16031046-16031126 ( 58) TTTTGCAG 1 chr1:117286304-117286384 ( 39) TTCTGCAA 1 chr2:170429413-170429493 ( 24) TTCTGCAA 1 chr11:2681742-2681822 ( 70) TTCTGCAA 1 chr7:138030447-138030527 ( 31) CTTTGCAG 1 chr7:149395063-149395143 ( 69) CTCTGCTG 1 chr12:96738210-96738290 ( 45) CTCTTCAG 1 chr7:99138343-99138423 ( 71) CTCTTCAG 1 chr19:9868267-9868347 ( 61) TTCTCCTG 1 chr1:20486697-20486777 ( 60) CTCTGAAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.14602 E= 3.2e-052 -1267 29 -1267 135 -1267 -271 -175 162 -1267 215 -216 -226 -1267 -1267 -1267 176 -1267 -25 195 -326 -426 229 -1267 -1267 169 -1267 -1267 -268 -268 -1267 220 -1267 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 65 E= 3.2e-052 0.000000 0.246154 0.000000 0.753846 0.000000 0.030769 0.061538 0.907692 0.000000 0.892308 0.046154 0.061538 0.000000 0.000000 0.000000 1.000000 0.000000 0.169231 0.800000 0.030769 0.015385 0.984615 0.000000 0.000000 0.953846 0.000000 0.000000 0.046154 0.046154 0.000000 0.953846 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCTGCAG MEME-1 regular expression -------------------------------------------------------------------------------- [TC]TCTGCAG -------------------------------------------------------------------------------- Time 5.06 secs. ******************************************************************************** ******************************************************************************** MOTIF CAGCAAGG MEME-2 width = 8 sites = 30 llr = 313 E-value = 2.4e-026 ******************************************************************************** -------------------------------------------------------------------------------- Motif CAGCAAGG MEME-2 Description -------------------------------------------------------------------------------- Simplified A 1a:1aa:: pos.-specific C 9::9:::: probability G 1:a:::aa matrix T :::::::: bits 2.3 * * 2.1 * ** 1.8 **** ** 1.6 ******** Relative 1.4 ******** Entropy 1.2 ******** (15.0 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CAGCAAGG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCAAGG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr15:80208269-80208349 28 9.39e-06 aaagtgtttt cagcaagg caattttact chr3:48655171-48655251 18 9.39e-06 aaagttttct cagcaagg caaatttact chr2:122440528-122440608 26 9.39e-06 ttaattttct cagcaagg caatttttac chr7:152430498-152430578 25 9.39e-06 agaattttct cagcaagg caattttact chr5:171406732-171406812 33 9.39e-06 ttaattttct cagcaagg ccatttttct chr6:35397397-35397477 16 9.39e-06 aaagttttct cagcaagg caattttact chr11:33953419-33953499 39 9.39e-06 ttaattttct cagcaagg caatttttac chr17:75170842-75170922 37 9.39e-06 aaggatttct cagcaagg caatttactt chr2:238871259-238871339 1 9.39e-06 . cagcaagg ctagtttagt chr3:196483748-196483828 36 9.39e-06 ttaactttct cagcaagg cagttttact chr18:19773691-19773771 31 9.39e-06 AGAGAGATTC CAGCAAGG AAGATAGAGC chr1:46859244-46859324 7 9.39e-06 tcttct cagcaagg caatttactt chr4:1740314-1740394 11 9.39e-06 ttaattttct cagcaagg cagtttttac chr22:42500515-42500595 9 9.39e-06 aattttct cagcaagg caatttactt chr1:147149960-147150040 23 9.39e-06 ttaattttct cagcaagg ccatttttac chr15:93493014-93493094 10 9.39e-06 gaattttct cagcaagg caattttact chr12:104628857-10462893 13 9.39e-06 aagaatttct cagcaagg caaatttact chr1:30565474-30565554 13 9.39e-06 ttaattttct cagcaagg caatttttac chr19:16332116-16332196 13 9.39e-06 aaagttttct cagcaagg caaatttact chr19:35408221-35408301 7 9.39e-06 ttttct cagcaagg ccatttttat chr7:72200984-72201064 7 9.39e-06 ttttct cagcaagg ccattttttt chr15:80212641-80212721 5 3.28e-05 tctg cagaaagg gtgctcctca chr6:35611586-35611666 52 3.28e-05 agatccttca gagcaagg tccatgcttt chr5:150211601-150211681 2 3.28e-05 g cagaaagg gtacactcgc chr2:48615854-48615934 43 3.28e-05 gttgcaaaaa cagaaagg gggaaacagg chr19:58132275-58132355 63 3.28e-05 GTTCACAATG GAGCAAGG CCTTATAAGT chr9:123567280-123567360 57 5.29e-05 agtggcatga aagcaagg atacagaggc chr8:130581873-130581953 26 5.29e-05 attcagaata aagcaagg acgtctgctt chr18:9424413-9424493 6 5.29e-05 tataa cagcacgg tggtgcagga chr1:228430134-228430214 10 6.63e-05 atttttcag cagcaatg aggagcccag -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCAAGG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr15:80208269-80208349 9.4e-06 27_[+2]_45 chr3:48655171-48655251 9.4e-06 17_[+2]_55 chr2:122440528-122440608 9.4e-06 25_[+2]_47 chr7:152430498-152430578 9.4e-06 24_[+2]_48 chr5:171406732-171406812 9.4e-06 32_[+2]_40 chr6:35397397-35397477 9.4e-06 15_[+2]_57 chr11:33953419-33953499 9.4e-06 38_[+2]_34 chr17:75170842-75170922 9.4e-06 36_[+2]_36 chr2:238871259-238871339 9.4e-06 [+2]_72 chr3:196483748-196483828 9.4e-06 35_[+2]_37 chr18:19773691-19773771 9.4e-06 30_[+2]_42 chr1:46859244-46859324 9.4e-06 6_[+2]_66 chr4:1740314-1740394 9.4e-06 10_[+2]_62 chr22:42500515-42500595 9.4e-06 8_[+2]_64 chr1:147149960-147150040 9.4e-06 22_[+2]_50 chr15:93493014-93493094 9.4e-06 9_[+2]_63 chr12:104628857-10462893 9.4e-06 12_[+2]_60 chr1:30565474-30565554 9.4e-06 12_[+2]_60 chr19:16332116-16332196 9.4e-06 12_[+2]_60 chr19:35408221-35408301 9.4e-06 6_[+2]_66 chr7:72200984-72201064 9.4e-06 6_[+2]_66 chr15:80212641-80212721 3.3e-05 4_[+2]_68 chr6:35611586-35611666 3.3e-05 51_[+2]_21 chr5:150211601-150211681 3.3e-05 1_[+2]_71 chr2:48615854-48615934 3.3e-05 42_[+2]_30 chr19:58132275-58132355 3.3e-05 62_[+2]_10 chr9:123567280-123567360 5.3e-05 56_[+2]_16 chr8:130581873-130581953 5.3e-05 25_[+2]_47 chr18:9424413-9424493 5.3e-05 5_[+2]_67 chr1:228430134-228430214 6.6e-05 9_[+2]_63 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCAAGG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CAGCAAGG width=8 seqs=30 chr15:80208269-80208349 ( 28) CAGCAAGG 1 chr3:48655171-48655251 ( 18) CAGCAAGG 1 chr2:122440528-122440608 ( 26) CAGCAAGG 1 chr7:152430498-152430578 ( 25) CAGCAAGG 1 chr5:171406732-171406812 ( 33) CAGCAAGG 1 chr6:35397397-35397477 ( 16) CAGCAAGG 1 chr11:33953419-33953499 ( 39) CAGCAAGG 1 chr17:75170842-75170922 ( 37) CAGCAAGG 1 chr2:238871259-238871339 ( 1) CAGCAAGG 1 chr3:196483748-196483828 ( 36) CAGCAAGG 1 chr18:19773691-19773771 ( 31) CAGCAAGG 1 chr1:46859244-46859324 ( 7) CAGCAAGG 1 chr4:1740314-1740394 ( 11) CAGCAAGG 1 chr22:42500515-42500595 ( 9) CAGCAAGG 1 chr1:147149960-147150040 ( 23) CAGCAAGG 1 chr15:93493014-93493094 ( 10) CAGCAAGG 1 chr12:104628857-10462893 ( 13) CAGCAAGG 1 chr1:30565474-30565554 ( 13) CAGCAAGG 1 chr19:16332116-16332196 ( 13) CAGCAAGG 1 chr19:35408221-35408301 ( 7) CAGCAAGG 1 chr7:72200984-72201064 ( 7) CAGCAAGG 1 chr15:80212641-80212721 ( 5) CAGAAAGG 1 chr6:35611586-35611666 ( 52) GAGCAAGG 1 chr5:150211601-150211681 ( 2) CAGAAAGG 1 chr2:48615854-48615934 ( 43) CAGAAAGG 1 chr19:58132275-58132355 ( 63) GAGCAAGG 1 chr9:123567280-123567360 ( 57) AAGCAAGG 1 chr8:130581873-130581953 ( 26) AAGCAAGG 1 chr18:9424413-9424493 ( 6) CAGCACGG 1 chr1:228430134-228430214 ( 10) CAGCAATG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCAAGG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.17126 E= 2.4e-026 -215 210 -163 -1155 176 -1155 -1155 -1155 -1155 -1155 227 -1155 -156 216 -1155 -1155 176 -1155 -1155 -1155 171 -259 -1155 -1155 -1155 -1155 222 -315 -1155 -1155 227 -1155 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCAAGG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 30 E= 2.4e-026 0.066667 0.866667 0.066667 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.100000 0.900000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.966667 0.033333 0.000000 0.000000 0.000000 0.000000 0.966667 0.033333 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCAAGG MEME-2 regular expression -------------------------------------------------------------------------------- CAGCAAGG -------------------------------------------------------------------------------- Time 8.80 secs. ******************************************************************************** ******************************************************************************** MOTIF GCYTTSCY MEME-3 width = 8 sites = 56 llr = 467 E-value = 2.7e-023 ******************************************************************************** -------------------------------------------------------------------------------- Motif GCYTTSCY MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::::::1 pos.-specific C :86::4a4 probability G 9::::6:: matrix T 124aa::5 bits 2.3 * 2.1 * 1.8 ** * 1.6 * ** * Relative 1.4 ** **** Entropy 1.2 ******* (12.0 bits) 0.9 ******* 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel GCCTTGCT consensus TT C C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTTSCY MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:25112709-25112789 59 6.25e-06 aataaaaact gccttgcc gagaaaatta chr19:37038278-37038358 61 1.24e-05 TACTCCAAAA GCCTTCCC ACATTCCTTA chr1:244739764-244739844 50 2.15e-05 aagtacaatt gccttgct gagaaaactt chr1:31931290-31931370 52 2.15e-05 aagtaaaatt gccttgct gagaaaactt chr11:63559430-63559510 22 2.15e-05 aattaaaatt gccttgct aagaaaactt chr3:10287166-10287246 38 2.15e-05 tgtaaaaatg gccttgct gagaaaatta chr1:117286304-117286384 56 2.15e-05 aagtaaatgt gccttgct gagaaatttt chr16:10588948-10589028 56 2.15e-05 aagtaaaatt gccttgct gagaaaatta chr17:37203395-37203475 51 2.15e-05 aagtaaattt gccttgct gagaaaatta chr18:11957067-11957147 50 2.15e-05 agtaaaaatt gccttgct gagaaaatta chr3:183161674-183161754 60 2.15e-05 aagtaaaatt gccttgct gagaaaatta chr1:180557406-180557486 59 2.15e-05 agtaaaaatt gccttgct aagacaactt chr10:17304681-17304761 38 2.15e-05 aagtaaattt gccttgct gagaaaactt chr7:152402018-152402098 53 2.15e-05 agtaaaaatt gccttgct gagaaaatta chr13:21139668-21139748 16 2.15e-05 gaagtaaatt gccttgct gagaaggaaa chr4:80127974-80128054 35 2.15e-05 agtaaaaata gccttgct gaaaaaatta chr8:125924017-125924097 55 2.15e-05 agtaaagatt gccttgct gagaaatctt chr12:807567-807647 38 2.15e-05 agtgaaaatg gccttgct gagaaaatta chr12:131341895-13134197 29 2.15e-05 gtagtaaatt gccttgct gagaaaattt chr6:109512782-109512862 3 2.15e-05 gg gccttgct gctttgtgca chr2:198348421-198348501 57 2.15e-05 agtaaaaatg gccttgct gagaaaatta chr7:66541266-66541346 55 2.15e-05 taaaaaaatg gccttgct gagaaaatta chr4:437279-437359 39 3.96e-05 CTGTCTAAAG GCTTTGCC ACATACTTCA chr10:42831534-42831614 1 3.96e-05 . GCTTTGCC GCATGCTTCA chr1:247150568-247150648 2 3.96e-05 A GCTTTGCC ACATTCCTCA chr9:99581032-99581112 68 4.85e-05 CTCACTGAAG GCTTTCCC GCACT chr8:130581873-130581953 1 4.85e-05 . gctttccc ccataagatt chr19:9634757-9634837 4 4.85e-05 AGG GCTTTCCC ACATTCCTTA chr19:9868267-9868347 29 4.85e-05 ATACCTGAAG GCTTTCCC ACATTCTTTA chr1:247320221-247320301 62 4.85e-05 GTAACGGAAG GCTTTCCC ACAGTGCTTA chr9:95609031-95609111 23 4.85e-05 CCTAGTGAAG GCTTTCCC ACAGTCACTA chr10:42832612-42832692 7 6.20e-05 TTAAAA GCTTTGCT ACATTCTTCG chr8:86970377-86970457 41 7.51e-05 cttcaactgt gctttcct ttggcaatat chr2:238871259-238871339 48 8.42e-05 ctcgctagca gtcttgcc atgagagcac chr7:130016482-130016562 67 1.16e-04 gacttgctcc tccttgcc ttctgc chr7:106645520-106645600 48 1.37e-04 CAATATAATT TCCTTCCC CTTAGAGTTG chr13:91726852-91726932 25 1.37e-04 TGCACTATGT TCCTTCCC TTACACATGC chr5:150211601-150211681 25 1.73e-04 ctcgccagca gttttgcc acaagagtac chr1:147149960-147150040 70 1.73e-04 ctcaccagca gttttgcc atg chr4:435635-435715 3 1.73e-04 AG GTTTTGCC ACATTCTCCA chr9:123570058-123570138 58 1.73e-04 atttgctttt tccttgct gctttcagca chr16:3274045-3274125 4 2.08e-04 AAG GTTTTCCC ACATTCTGGA chr19:12053698-12053778 15 2.08e-04 agaggtggtc tccttcct tattcccccc chr2:46486197-46486277 9 2.08e-04 tccccttt gccttcca ccatgatgca chr7:138017737-138017817 53 2.08e-04 ctctaaatat gccttcca tatcctgcac chr2:112866969-112867049 37 2.08e-04 tatttacttt tccttcct ttttaaagga chr7:6730807-6730887 12 2.08e-04 CTGGCAGAAG GTTTTCCC ACATTCACTA chr6:28963237-28963317 22 2.08e-04 ATCTTGGAAG GTTTTCCC ACAATCCCTG chr1:114905970-114906050 72 2.08e-04 aggggtggtc tccttcct t chr1:117409247-117409327 35 2.08e-04 ctctaaatat gccttcca tatcctgcac chr17:44999921-45000001 54 2.08e-04 GAGGAACCCG GTTTTCCC TACTTTACAC chr8:146107473-146107553 70 2.08e-04 CACACTGAAG GTTTTCCC ACA chr17:18565408-18565488 71 2.08e-04 CTGGCTGAAG GTTTTCCC AC chr10:52320599-52320679 41 2.60e-04 CCTTTATACC GTTTTCCT AACAGTTTTT chr12:124653718-12465379 5 2.60e-04 tact gttttcct ggtagtgaat chr15:68577141-68577221 9 2.73e-04 gaagcagg tctttccc gtgctgttct -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTTSCY MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:25112709-25112789 6.3e-06 58_[+3]_14 chr19:37038278-37038358 1.2e-05 60_[+3]_12 chr1:244739764-244739844 2.2e-05 49_[+3]_23 chr1:31931290-31931370 2.2e-05 51_[+3]_21 chr11:63559430-63559510 2.2e-05 21_[+3]_51 chr3:10287166-10287246 2.2e-05 37_[+3]_35 chr1:117286304-117286384 2.2e-05 55_[+3]_17 chr16:10588948-10589028 2.2e-05 55_[+3]_17 chr17:37203395-37203475 2.2e-05 50_[+3]_22 chr18:11957067-11957147 2.2e-05 49_[+3]_23 chr3:183161674-183161754 2.2e-05 59_[+3]_13 chr1:180557406-180557486 2.2e-05 58_[+3]_14 chr10:17304681-17304761 2.2e-05 37_[+3]_35 chr7:152402018-152402098 2.2e-05 52_[+3]_20 chr13:21139668-21139748 2.2e-05 15_[+3]_57 chr4:80127974-80128054 2.2e-05 34_[+3]_38 chr8:125924017-125924097 2.2e-05 54_[+3]_18 chr12:807567-807647 2.2e-05 37_[+3]_35 chr12:131341895-13134197 2.2e-05 28_[+3]_44 chr6:109512782-109512862 2.2e-05 2_[+3]_70 chr2:198348421-198348501 2.2e-05 56_[+3]_16 chr7:66541266-66541346 2.2e-05 54_[+3]_18 chr4:437279-437359 4e-05 38_[+3]_34 chr10:42831534-42831614 4e-05 [+3]_72 chr1:247150568-247150648 4e-05 1_[+3]_71 chr9:99581032-99581112 4.9e-05 67_[+3]_5 chr8:130581873-130581953 4.9e-05 [+3]_72 chr19:9634757-9634837 4.9e-05 3_[+3]_69 chr19:9868267-9868347 4.9e-05 28_[+3]_44 chr1:247320221-247320301 4.9e-05 61_[+3]_11 chr9:95609031-95609111 4.9e-05 22_[+3]_50 chr10:42832612-42832692 6.2e-05 6_[+3]_66 chr8:86970377-86970457 7.5e-05 40_[+3]_32 chr2:238871259-238871339 8.4e-05 47_[+3]_25 chr7:130016482-130016562 0.00012 66_[+3]_6 chr7:106645520-106645600 0.00014 47_[+3]_25 chr13:91726852-91726932 0.00014 24_[+3]_48 chr5:150211601-150211681 0.00017 24_[+3]_48 chr1:147149960-147150040 0.00017 69_[+3]_3 chr4:435635-435715 0.00017 2_[+3]_70 chr9:123570058-123570138 0.00017 57_[+3]_15 chr16:3274045-3274125 0.00021 3_[+3]_69 chr19:12053698-12053778 0.00021 14_[+3]_58 chr2:46486197-46486277 0.00021 8_[+3]_64 chr7:138017737-138017817 0.00021 52_[+3]_20 chr2:112866969-112867049 0.00021 36_[+3]_36 chr7:6730807-6730887 0.00021 11_[+3]_61 chr6:28963237-28963317 0.00021 21_[+3]_51 chr1:114905970-114906050 0.00021 71_[+3]_1 chr1:117409247-117409327 0.00021 34_[+3]_38 chr17:44999921-45000001 0.00021 53_[+3]_19 chr8:146107473-146107553 0.00021 69_[+3]_3 chr17:18565408-18565488 0.00021 70_[+3]_2 chr10:52320599-52320679 0.00026 40_[+3]_32 chr12:124653718-12465379 0.00026 4_[+3]_68 chr15:68577141-68577221 0.00027 8_[+3]_64 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTTSCY MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GCYTTSCY width=8 seqs=56 chr22:25112709-25112789 ( 59) GCCTTGCC 1 chr19:37038278-37038358 ( 61) GCCTTCCC 1 chr1:244739764-244739844 ( 50) GCCTTGCT 1 chr1:31931290-31931370 ( 52) GCCTTGCT 1 chr11:63559430-63559510 ( 22) GCCTTGCT 1 chr3:10287166-10287246 ( 38) GCCTTGCT 1 chr1:117286304-117286384 ( 56) GCCTTGCT 1 chr16:10588948-10589028 ( 56) GCCTTGCT 1 chr17:37203395-37203475 ( 51) GCCTTGCT 1 chr18:11957067-11957147 ( 50) GCCTTGCT 1 chr3:183161674-183161754 ( 60) GCCTTGCT 1 chr1:180557406-180557486 ( 59) GCCTTGCT 1 chr10:17304681-17304761 ( 38) GCCTTGCT 1 chr7:152402018-152402098 ( 53) GCCTTGCT 1 chr13:21139668-21139748 ( 16) GCCTTGCT 1 chr4:80127974-80128054 ( 35) GCCTTGCT 1 chr8:125924017-125924097 ( 55) GCCTTGCT 1 chr12:807567-807647 ( 38) GCCTTGCT 1 chr12:131341895-13134197 ( 29) GCCTTGCT 1 chr6:109512782-109512862 ( 3) GCCTTGCT 1 chr2:198348421-198348501 ( 57) GCCTTGCT 1 chr7:66541266-66541346 ( 55) GCCTTGCT 1 chr4:437279-437359 ( 39) GCTTTGCC 1 chr10:42831534-42831614 ( 1) GCTTTGCC 1 chr1:247150568-247150648 ( 2) GCTTTGCC 1 chr9:99581032-99581112 ( 68) GCTTTCCC 1 chr8:130581873-130581953 ( 1) GCTTTCCC 1 chr19:9634757-9634837 ( 4) GCTTTCCC 1 chr19:9868267-9868347 ( 29) GCTTTCCC 1 chr1:247320221-247320301 ( 62) GCTTTCCC 1 chr9:95609031-95609111 ( 23) GCTTTCCC 1 chr10:42832612-42832692 ( 7) GCTTTGCT 1 chr8:86970377-86970457 ( 41) GCTTTCCT 1 chr2:238871259-238871339 ( 48) GTCTTGCC 1 chr7:130016482-130016562 ( 67) TCCTTGCC 1 chr7:106645520-106645600 ( 48) TCCTTCCC 1 chr13:91726852-91726932 ( 25) TCCTTCCC 1 chr5:150211601-150211681 ( 25) GTTTTGCC 1 chr1:147149960-147150040 ( 70) GTTTTGCC 1 chr4:435635-435715 ( 3) GTTTTGCC 1 chr9:123570058-123570138 ( 58) TCCTTGCT 1 chr16:3274045-3274125 ( 4) GTTTTCCC 1 chr19:12053698-12053778 ( 15) TCCTTCCT 1 chr2:46486197-46486277 ( 9) GCCTTCCA 1 chr7:138017737-138017817 ( 53) GCCTTCCA 1 chr2:112866969-112867049 ( 37) TCCTTCCT 1 chr7:6730807-6730887 ( 12) GTTTTCCC 1 chr6:28963237-28963317 ( 22) GTTTTCCC 1 chr1:114905970-114906050 ( 72) TCCTTCCT 1 chr1:117409247-117409327 ( 35) GCCTTCCA 1 chr17:44999921-45000001 ( 54) GTTTTCCC 1 chr8:146107473-146107553 ( 70) GTTTTCCC 1 chr17:18565408-18565488 ( 71) GTTTTCCC 1 chr10:52320599-52320679 ( 41) GTTTTCCT 1 chr12:124653718-12465379 ( 5) GTTTTCCT 1 chr15:68577141-68577221 ( 9) TCTTTCCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTTSCY MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.56875 E= 2.7e-023 -1245 -1245 205 -105 -1245 196 -1245 -47 -1245 155 -1245 47 -1245 -1245 -1245 176 -1245 -1245 -1245 176 -1245 115 142 -1245 -1245 231 -1245 -1245 -246 115 -1245 76 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTTSCY MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 56 E= 2.7e-023 0.000000 0.000000 0.857143 0.142857 0.000000 0.785714 0.000000 0.214286 0.000000 0.589286 0.000000 0.410714 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.446429 0.553571 0.000000 0.000000 1.000000 0.000000 0.000000 0.053571 0.446429 0.000000 0.500000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCYTTSCY MEME-3 regular expression -------------------------------------------------------------------------------- G[CT][CT]TT[GC]C[TC] -------------------------------------------------------------------------------- Time 12.54 secs. ******************************************************************************** ******************************************************************************** MOTIF AAGGGTGC MEME-4 width = 8 sites = 33 llr = 314 E-value = 6.1e-018 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 Description -------------------------------------------------------------------------------- Simplified A 9a::::1: pos.-specific C 1::::::7 probability G ::aaa292 matrix T :::::8:1 bits 2.3 *** 2.1 *** 1.8 *** 1.6 **** * Relative 1.4 ***** * Entropy 1.2 ******** (13.7 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AAGGGTGC consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr15:80208269-80208349 55 9.62e-06 tttctgcaga aagggtgc tcctcacagg chr3:48655171-48655251 45 9.62e-06 tttctgcaga aagggtgc tccttgcaga chr2:122440528-122440608 54 9.62e-06 tttctgcaga aagggtgc tcctcacaga chr7:152430498-152430578 52 9.62e-06 tttctgcaga aagggtgc ttcttggaag chr11:33953419-33953499 65 9.62e-06 acttctatag aagggtgc gactcacg chr17:75170842-75170922 61 9.62e-06 acttttgcag aagggtgc cgcctgcatc chr2:238871259-238871339 28 9.62e-06 tttctgcaga aagggtgc cgctcgctag chr3:196483748-196483828 63 9.62e-06 ttgctgcata aagggtgc tcctcgcaga chr1:46859244-46859324 31 9.62e-06 acttctatag aagggtgc gccctcacag chr1:204492902-204492982 13 9.62e-06 acttctatgg aagggtgc atctcacgga chr4:1740314-1740394 39 9.62e-06 tttctgcaga aagggtgc ccctcgcaga chr22:42500515-42500595 33 9.62e-06 acttctgcag aagggtgc tgcttgtgtc chr15:93493014-93493094 37 9.62e-06 tttctgcaga aagggtgc ttcttggaag chr1:30565474-30565554 41 9.62e-06 tttctgcaga aagggtgc tcttcacaga chr19:16332116-16332196 40 9.62e-06 tttctgcaga aagggtgc tcctcgcaga chr17:45142199-45142279 58 9.62e-06 tttctgcaga aagggtgc tcatcataga chr1:160955643-160955723 31 1.95e-05 gtacattctc aagggtgg ggaggatgtt chr14:91667318-91667398 48 1.95e-05 gtaccttctc aagggtgg ggagggtgta chr7:99138343-99138423 58 1.95e-05 CACTCGCCGT AAGGGTGG AATTGCTCTT chr5:171406732-171406812 63 4.65e-05 tttctgcaga aagggtac actcgccagc chr1:147149960-147150040 51 4.65e-05 tttctgcaga aagggtac actcaccagc chr19:35408221-35408301 37 4.65e-05 tttctgcaga aagggtac actcgccatt chr7:72200984-72201064 37 4.65e-05 tttctgcaga aagggtac actcgccagc chr1:211867403-211867483 48 5.34e-05 gagattctca aagggggg gaataaggga chr1:20486697-20486777 15 5.34e-05 gagattctca aagggggg aaTGAGAAGT chr21:34036559-34036639 46 5.34e-05 gaagttctca aagggggg aataagggag chr17:29965640-29965720 61 6.01e-05 ctggcccacc cagggtgg aaaaccactt chr19:39426189-39426269 16 6.01e-05 ccacgacctt cagggtgg gggtcatggc chr4:72729355-72729435 73 7.88e-05 aaaaccactt aagggtgt chr6:35397397-35397477 43 7.88e-05 tttctgcagg aagggtgt tcctcacaga chr22:17132256-17132336 18 7.88e-05 aaagtgggtc cagggggc caatgctagt chr7:135949178-135949258 65 7.88e-05 aaagtgggac cagggggc cattgcga chr12:133780923-13378100 24 8.84e-05 GAGAAACCCT ATGGGTGC AATGAATGTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr15:80208269-80208349 9.6e-06 54_[+4]_18 chr3:48655171-48655251 9.6e-06 44_[+4]_28 chr2:122440528-122440608 9.6e-06 53_[+4]_19 chr7:152430498-152430578 9.6e-06 51_[+4]_21 chr11:33953419-33953499 9.6e-06 64_[+4]_8 chr17:75170842-75170922 9.6e-06 60_[+4]_12 chr2:238871259-238871339 9.6e-06 27_[+4]_45 chr3:196483748-196483828 9.6e-06 62_[+4]_10 chr1:46859244-46859324 9.6e-06 30_[+4]_42 chr1:204492902-204492982 9.6e-06 12_[+4]_60 chr4:1740314-1740394 9.6e-06 38_[+4]_34 chr22:42500515-42500595 9.6e-06 32_[+4]_40 chr15:93493014-93493094 9.6e-06 36_[+4]_36 chr1:30565474-30565554 9.6e-06 40_[+4]_32 chr19:16332116-16332196 9.6e-06 39_[+4]_33 chr17:45142199-45142279 9.6e-06 57_[+4]_15 chr1:160955643-160955723 1.9e-05 30_[+4]_42 chr14:91667318-91667398 1.9e-05 47_[+4]_25 chr7:99138343-99138423 1.9e-05 57_[+4]_15 chr5:171406732-171406812 4.7e-05 62_[+4]_10 chr1:147149960-147150040 4.7e-05 50_[+4]_22 chr19:35408221-35408301 4.7e-05 36_[+4]_36 chr7:72200984-72201064 4.7e-05 36_[+4]_36 chr1:211867403-211867483 5.3e-05 47_[+4]_25 chr1:20486697-20486777 5.3e-05 14_[+4]_58 chr21:34036559-34036639 5.3e-05 45_[+4]_27 chr17:29965640-29965720 6e-05 60_[+4]_12 chr19:39426189-39426269 6e-05 15_[+4]_57 chr4:72729355-72729435 7.9e-05 72_[+4] chr6:35397397-35397477 7.9e-05 42_[+4]_30 chr22:17132256-17132336 7.9e-05 17_[+4]_55 chr7:135949178-135949258 7.9e-05 64_[+4]_8 chr12:133780923-13378100 8.8e-05 23_[+4]_49 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAGGGTGC width=8 seqs=33 chr15:80208269-80208349 ( 55) AAGGGTGC 1 chr3:48655171-48655251 ( 45) AAGGGTGC 1 chr2:122440528-122440608 ( 54) AAGGGTGC 1 chr7:152430498-152430578 ( 52) AAGGGTGC 1 chr11:33953419-33953499 ( 65) AAGGGTGC 1 chr17:75170842-75170922 ( 61) AAGGGTGC 1 chr2:238871259-238871339 ( 28) AAGGGTGC 1 chr3:196483748-196483828 ( 63) AAGGGTGC 1 chr1:46859244-46859324 ( 31) AAGGGTGC 1 chr1:204492902-204492982 ( 13) AAGGGTGC 1 chr4:1740314-1740394 ( 39) AAGGGTGC 1 chr22:42500515-42500595 ( 33) AAGGGTGC 1 chr15:93493014-93493094 ( 37) AAGGGTGC 1 chr1:30565474-30565554 ( 41) AAGGGTGC 1 chr19:16332116-16332196 ( 40) AAGGGTGC 1 chr17:45142199-45142279 ( 58) AAGGGTGC 1 chr1:160955643-160955723 ( 31) AAGGGTGG 1 chr14:91667318-91667398 ( 48) AAGGGTGG 1 chr7:99138343-99138423 ( 58) AAGGGTGG 1 chr5:171406732-171406812 ( 63) AAGGGTAC 1 chr1:147149960-147150040 ( 51) AAGGGTAC 1 chr19:35408221-35408301 ( 37) AAGGGTAC 1 chr7:72200984-72201064 ( 37) AAGGGTAC 1 chr1:211867403-211867483 ( 48) AAGGGGGG 1 chr1:20486697-20486777 ( 15) AAGGGGGG 1 chr21:34036559-34036639 ( 46) AAGGGGGG 1 chr17:29965640-29965720 ( 61) CAGGGTGG 1 chr19:39426189-39426269 ( 16) CAGGGTGG 1 chr4:72729355-72729435 ( 73) AAGGGTGT 1 chr6:35397397-35397477 ( 43) AAGGGTGT 1 chr22:17132256-17132336 ( 18) CAGGGGGC 1 chr7:135949178-135949258 ( 65) CAGGGGGC 1 chr12:133780923-13378100 ( 24) ATGGGTGC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.87609 E= 6.1e-018 157 -73 -1169 -1169 171 -1169 -1169 -328 -1169 -1169 227 -1169 -1169 -1169 227 -1169 -1169 -1169 227 -1169 -1169 -1169 -45 152 -129 -1169 209 -1169 -1169 179 23 -229 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 33 E= 6.1e-018 0.878788 0.121212 0.000000 0.000000 0.969697 0.000000 0.000000 0.030303 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.151515 0.848485 0.121212 0.000000 0.878788 0.000000 0.000000 0.696970 0.242424 0.060606 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGGGTGC MEME-4 regular expression -------------------------------------------------------------------------------- AAGGGTG[CG] -------------------------------------------------------------------------------- Time 16.12 secs. ******************************************************************************** ******************************************************************************** MOTIF TGTGGGAA MEME-5 width = 8 sites = 28 llr = 258 E-value = 3.3e-007 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGTGGGAA MEME-5 Description -------------------------------------------------------------------------------- Simplified A ::3::17a pos.-specific C ::::::2: probability G :a:aa9:: matrix T a:7:::1: bits 2.3 * * 2.1 * ** 1.8 ** ** * 1.6 ** *** * Relative 1.4 ** *** * Entropy 1.2 ** *** * (13.3 bits) 0.9 ****** * 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TGTGGGAA consensus A C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGGGAA MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:44536386-44536466 57 1.41e-05 ATGTGAGCAG TGTGGGAA AGGCTTCAGA chr19:14829501-14829581 1 1.41e-05 . TGTGGGAA AGCCTTCAAT chr8:195497-195577 32 1.41e-05 ATGTCATCTA TGTGGGAA AGCCTTTACT chr3:44683902-44683982 11 1.41e-05 ATGTAATGAA TGTGGGAA AGCATTTTCT chr15:85164768-85164848 9 1.41e-05 GTGGGGTG TGTGGGAA GAGCTTCAGC chr19:2917500-2917580 56 1.41e-05 ATGCAAGCAG TGTGGGAA AACATTCAGT chr8:144732731-144732811 29 1.41e-05 ATGCAAAGAG TGTGGGAA AGGCTTCAGT chr19:58132275-58132355 5 1.41e-05 TGAA TGTGGGAA ATATTTTAGC chr19:12060681-12060761 31 1.41e-05 GTGTAAGCAA TGTGGGAA AGCCTTCAGA chr9:104171386-104171466 45 1.41e-05 ATGTGATGAA TGTGGGAA AACTTTTAGT chr12:133780923-13378100 38 1.41e-05 GTGCAATGAA TGTGGGAA AACCTTCTCT chr19:11917747-11917827 15 1.41e-05 GTGTAAGCAA TGTGGGAA AGCCTTCAGA chr19:11944505-11944585 64 1.41e-05 ATATAAGCAA TGTGGGAA AGCCTTCAG chr8:30004983-30005063 11 2.37e-05 aaccttccag tgtgggca tcatggccat chr6:111243872-111243952 42 3.78e-05 tttaccagaa tgagggaa ggaacaccta chr19:12016887-12016967 24 3.78e-05 GTGTAAGCAA TGAGGGAA AGCCTTCAGA chr4:72729355-72729435 29 4.74e-05 tttaccggaa tgagggca aggagcacct chr17:29965640-29965720 35 4.74e-05 tttaccagaa tgagggca aggaacacct chr17:44999921-45000001 35 4.74e-05 AGAACCTCTT TGAGGGCA GGAGGAACCC chr1:247193039-247193119 59 4.74e-05 tttacaggaa tgagggca aggaacacct chr3:143276964-143277044 13 6.15e-05 gtgtggagcc tgtgggta catagaagtt chr10:62737545-62737625 64 6.15e-05 TGTAATGCTT TGTGGGTA AAATAAATA chr17:15620379-15620459 70 8.17e-05 ATGTAGCGAG TGTGGAAA AGC chr7:5104703-5104783 14 8.17e-05 ATGTAATGTA TGTGGAAA GTTATTCAAT chr11:47897566-47897646 1 9.58e-05 . tgagggta ctgcgggaga chr3:139024919-139024999 23 1.10e-04 gcccagacat tgtggaca aagtgtccca chr10:52320599-52320679 5 1.30e-04 AAAG TGAGGAAA GAACATTTGC chr12:57303390-57303470 69 1.50e-04 ctagtggagc tgtgagaa gagg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGGGAA MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:44536386-44536466 1.4e-05 56_[+5]_16 chr19:14829501-14829581 1.4e-05 [+5]_72 chr8:195497-195577 1.4e-05 31_[+5]_41 chr3:44683902-44683982 1.4e-05 10_[+5]_62 chr15:85164768-85164848 1.4e-05 8_[+5]_64 chr19:2917500-2917580 1.4e-05 55_[+5]_17 chr8:144732731-144732811 1.4e-05 28_[+5]_44 chr19:58132275-58132355 1.4e-05 4_[+5]_68 chr19:12060681-12060761 1.4e-05 30_[+5]_42 chr9:104171386-104171466 1.4e-05 44_[+5]_28 chr12:133780923-13378100 1.4e-05 37_[+5]_35 chr19:11917747-11917827 1.4e-05 14_[+5]_58 chr19:11944505-11944585 1.4e-05 63_[+5]_9 chr8:30004983-30005063 2.4e-05 10_[+5]_62 chr6:111243872-111243952 3.8e-05 41_[+5]_31 chr19:12016887-12016967 3.8e-05 23_[+5]_49 chr4:72729355-72729435 4.7e-05 28_[+5]_44 chr17:29965640-29965720 4.7e-05 34_[+5]_38 chr17:44999921-45000001 4.7e-05 34_[+5]_38 chr1:247193039-247193119 4.7e-05 58_[+5]_14 chr3:143276964-143277044 6.2e-05 12_[+5]_60 chr10:62737545-62737625 6.2e-05 63_[+5]_9 chr17:15620379-15620459 8.2e-05 69_[+5]_3 chr7:5104703-5104783 8.2e-05 13_[+5]_59 chr11:47897566-47897646 9.6e-05 [+5]_72 chr3:139024919-139024999 0.00011 22_[+5]_50 chr10:52320599-52320679 0.00013 4_[+5]_68 chr12:57303390-57303470 0.00015 68_[+5]_4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGGGAA MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGTGGGAA width=8 seqs=28 chr19:44536386-44536466 ( 57) TGTGGGAA 1 chr19:14829501-14829581 ( 1) TGTGGGAA 1 chr8:195497-195577 ( 32) TGTGGGAA 1 chr3:44683902-44683982 ( 11) TGTGGGAA 1 chr15:85164768-85164848 ( 9) TGTGGGAA 1 chr19:2917500-2917580 ( 56) TGTGGGAA 1 chr8:144732731-144732811 ( 29) TGTGGGAA 1 chr19:58132275-58132355 ( 5) TGTGGGAA 1 chr19:12060681-12060761 ( 31) TGTGGGAA 1 chr9:104171386-104171466 ( 45) TGTGGGAA 1 chr12:133780923-13378100 ( 38) TGTGGGAA 1 chr19:11917747-11917827 ( 15) TGTGGGAA 1 chr19:11944505-11944585 ( 64) TGTGGGAA 1 chr8:30004983-30005063 ( 11) TGTGGGCA 1 chr6:111243872-111243952 ( 42) TGAGGGAA 1 chr19:12016887-12016967 ( 24) TGAGGGAA 1 chr4:72729355-72729435 ( 29) TGAGGGCA 1 chr17:29965640-29965720 ( 35) TGAGGGCA 1 chr17:44999921-45000001 ( 35) TGAGGGCA 1 chr1:247193039-247193119 ( 59) TGAGGGCA 1 chr3:143276964-143277044 ( 13) TGTGGGTA 1 chr10:62737545-62737625 ( 64) TGTGGGTA 1 chr17:15620379-15620459 ( 70) TGTGGAAA 1 chr7:5104703-5104783 ( 14) TGTGGAAA 1 chr11:47897566-47897646 ( 1) TGAGGGTA 1 chr3:139024919-139024999 ( 23) TGTGGACA 1 chr10:52320599-52320679 ( 5) TGAGGAAA 1 chr12:57303390-57303470 ( 69) TGTGAGAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGGGAA MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.95252 E= 3.3e-007 -1145 -1145 -1145 176 -1145 -1145 227 -1145 -5 -1145 -1145 127 -1145 -1145 227 -1145 -305 -1145 222 -1145 -105 -1145 205 -1145 120 9 -1145 -146 176 -1145 -1145 -1145 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGGGAA MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 28 E= 3.3e-007 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.285714 0.000000 0.000000 0.714286 0.000000 0.000000 1.000000 0.000000 0.035714 0.000000 0.964286 0.000000 0.142857 0.000000 0.857143 0.000000 0.678571 0.214286 0.000000 0.107143 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGGGAA MEME-5 regular expression -------------------------------------------------------------------------------- TG[TA]GGG[AC]A -------------------------------------------------------------------------------- Time 19.64 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:436701-436781 2.99e-02 80 chr19:12016887-12016967 4.90e-03 23_[+5(3.78e-05)]_49 chr1:247150568-247150648 3.18e-02 1_[+3(3.96e-05)]_71 chr7:149229853-149229933 2.85e-01 80 chr12:31761366-31761446 1.53e-01 80 chr11:2681742-2681822 3.36e-02 80 chr1:228432859-228432939 8.27e-01 80 chr19:11944505-11944585 1.73e-03 63_[+5(1.41e-05)]_9 chr10:44020004-44020084 3.43e-01 80 chr19:52618923-52619003 5.78e-02 23_[+1(4.46e-05)]_49 chr19:39426189-39426269 7.23e-03 15_[+4(6.01e-05)]_29_[+1(5.40e-05)]_\ 20 chr7:33158154-33158234 1.83e-01 80 chr7:66541266-66541346 1.29e-05 32_[+1(1.34e-05)]_14_[+3(2.15e-05)]_\ 18 chr10:42831534-42831614 5.34e-03 [+3(3.96e-05)]_24_[+1(4.46e-05)]_40 chr17:18565408-18565488 8.63e-02 80 chr10:43088903-43088983 2.45e-01 80 chr6:16031046-16031126 2.76e-01 80 chr9:123570058-123570138 4.05e-02 80 chr15:28554071-28554151 1.22e-01 80 chr11:47897566-47897646 2.72e-02 [+5(9.58e-05)]_72 chr7:151735630-151735710 9.70e-01 80 chr7:5104703-5104783 1.76e-01 13_[+5(8.17e-05)]_59 chr4:435635-435715 1.84e-03 34_[+1(4.46e-05)]_38 chr2:198348421-198348501 1.29e-05 36_[+1(1.34e-05)]_12_[+3(2.15e-05)]_\ 16 chr7:72200984-72201064 4.28e-06 6_[+2(9.39e-06)]_13_[+1(1.34e-05)]_\ 1_[+4(4.65e-05)]_36 chr3:138592925-138593005 6.99e-03 63_[+1(1.34e-05)]_9 chrX:2793191-2793271 1.49e-01 80 chr7:111370281-111370361 3.26e-01 80 chr6:109512782-109512862 7.95e-04 2_[+3(2.15e-05)]_70 chr7:99138343-99138423 1.01e-03 57_[+4(1.95e-05)]_15 chr17:15620379-15620459 2.80e-02 69_[+5(8.17e-05)]_3 chr3:194255135-194255215 4.85e-02 80 chr10:42832612-42832692 6.23e-03 6_[+3(6.20e-05)]_24_[+1(4.46e-05)]_\ 34 chr2:170429413-170429493 1.82e-01 80 chr20:55096191-55096271 4.56e-01 80 chr12:131341895-13134197 6.42e-04 28_[+3(2.15e-05)]_44 chr10:47539342-47539422 9.09e-01 80 chr12:807567-807647 1.29e-05 17_[+1(1.34e-05)]_12_[+3(2.15e-05)]_\ 35 chr9:95609031-95609111 1.81e-03 22_[+3(4.85e-05)]_24_[+1(4.46e-05)]_\ 18 chr10:49685303-49685383 7.53e-01 80 chr1:247193039-247193119 8.94e-03 58_[+5(4.74e-05)]_14 chr8:86973134-86973214 5.99e-01 80 chr12:50886017-50886097 1.17e-01 80 chr17:45142199-45142279 4.38e-06 48_[+1(1.34e-05)]_1_[+4(9.62e-06)]_\ 15 chr7:23515334-23515414 9.95e-01 80 chr22:22485278-22485358 7.33e-01 80 chr7:12761989-12762069 2.77e-01 80 chr19:12187332-12187412 1.99e-02 80 chr19:35408221-35408301 2.17e-07 6_[+2(9.39e-06)]_13_[+1(1.34e-05)]_\ 1_[+4(4.65e-05)]_36 chr6:28936669-28936749 6.20e-01 80 chr6:111243872-111243952 2.02e-02 41_[+5(3.78e-05)]_31 chr8:125924017-125924097 9.94e-05 34_[+1(1.34e-05)]_12_[+3(2.15e-05)]_\ 18 chr19:11917747-11917827 3.60e-04 14_[+5(1.41e-05)]_58 chr8:146107473-146107553 1.59e-03 39_[+1(5.40e-05)]_33 chr17:44999921-45000001 1.31e-02 34_[+5(4.74e-05)]_38 chr10:62737545-62737625 3.41e-02 63_[+5(6.15e-05)]_9 chr6:109613826-109613906 6.85e-01 80 chr19:16332116-16332196 6.24e-07 12_[+2(9.39e-06)]_10_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_33 chr12:133780923-13378100 4.64e-04 23_[+4(8.84e-05)]_6_[+5(1.41e-05)]_\ 35 chr20:60650972-60651052 5.76e-01 80 chr1:36106091-36106171 4.36e-01 80 chr1:247320221-247320301 8.55e-04 9_[+1(4.46e-05)]_44_[+3(4.85e-05)]_\ 11 chr7:56220632-56220712 4.73e-03 64_[+1(2.26e-05)]_8 chrX:2756223-2756303 7.65e-01 80 chr19:37038278-37038358 5.39e-03 60_[+3(1.24e-05)]_12 chr7:106304171-106304251 9.81e-01 80 chr13:90574389-90574469 1.78e-01 80 chr1:117409247-117409327 7.30e-02 80 chr7:149395063-149395143 6.76e-03 80 chr1:142802557-142802637 5.26e-01 80 chr17:29965640-29965720 1.02e-04 34_[+5(4.74e-05)]_18_[+4(6.01e-05)]_\ 12 chr3:139024919-139024999 5.96e-02 80 chr4:437279-437359 5.60e-04 38_[+3(3.96e-05)]_24_[+1(4.46e-05)]_\ 2 chr11:3317588-3317668 5.01e-01 80 chr4:80127974-80128054 3.01e-05 14_[+1(1.34e-05)]_12_[+3(2.15e-05)]_\ 38 chr7:138030447-138030527 2.64e-02 80 chr16:31554225-31554305 1.17e-01 80 chr1:114905970-114906050 3.37e-02 80 chr14:91667318-91667398 4.00e-03 13_[+4(6.01e-05)]_26_[+4(1.95e-05)]_\ 25 chr9:104171386-104171466 2.17e-02 44_[+5(1.41e-05)]_28 chr19:9868267-9868347 3.06e-03 28_[+3(4.85e-05)]_44 chr21:34036559-34036639 1.72e-02 45_[+4(5.34e-05)]_27 chr19:9634757-9634837 3.08e-02 3_[+3(4.85e-05)]_69 chr7:141279965-141280045 5.69e-02 80 chr7:148733923-148734003 7.22e-03 10_[+1(5.40e-05)]_62 chr13:21139668-21139748 3.87e-02 15_[+3(2.15e-05)]_57 chr5:34782150-34782230 6.15e-03 80 chr10:104970100-10497018 5.09e-02 80 chr7:110656151-110656231 5.20e-01 80 chr18:9424413-9424493 5.50e-03 5_[+2(5.29e-05)]_67 chr1:30565474-30565554 8.52e-07 12_[+2(9.39e-06)]_11_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_32 chr19:12060681-12060761 2.87e-03 30_[+5(1.41e-05)]_42 chr1:228431692-228431772 5.02e-01 80 chrX:134421350-134421430 4.61e-01 80 chr6:28963237-28963317 2.26e-01 80 chr13:91726852-91726932 1.41e-01 80 chr22:23211184-23211264 1.70e-01 80 chr19:58132275-58132355 7.08e-04 4_[+5(1.41e-05)]_50_[+2(3.28e-05)]_\ 10 chr1:225967393-225967473 3.00e-01 80 chr13:91287380-91287460 9.76e-01 80 chr12:104628857-10462893 4.64e-06 12_[+2(9.39e-06)]_9_[+1(1.34e-05)]_\ 43 chr3:13220819-13220899 8.20e-01 80 chr1:166674254-166674334 8.96e-01 80 chr7:6730807-6730887 4.25e-02 80 chr1:23348438-23348518 3.60e-01 80 chr8:144732731-144732811 2.87e-03 28_[+5(1.41e-05)]_44 chr15:93493014-93493094 9.99e-08 9_[+2(9.39e-06)]_10_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_36 chr13:91860001-91860081 5.41e-01 80 chr2:48615854-48615934 5.40e-03 42_[+2(3.28e-05)]_30 chr8:130581873-130581953 4.72e-03 [+3(4.85e-05)]_17_[+2(5.29e-05)]_47 chr7:152402018-152402098 2.29e-05 32_[+1(1.34e-05)]_12_[+3(2.15e-05)]_\ 20 chr10:17304681-17304761 1.21e-05 18_[+1(1.34e-05)]_11_[+3(2.15e-05)]_\ 35 chr10:47541063-47541143 6.72e-01 80 chr18:23854129-23854209 6.21e-01 80 chr1:147149960-147150040 3.55e-07 22_[+2(9.39e-06)]_11_[+1(1.34e-05)]_\ 1_[+4(4.65e-05)]_22 chr7:106122205-106122285 2.82e-01 80 chr22:41611615-41611695 4.25e-01 80 chr1:28836087-28836167 9.65e-01 80 chr13:92130450-92130530 1.05e-02 80 chr12:124653718-12465379 4.73e-02 80 chr8:37880118-37880198 2.48e-01 80 chr19:2917500-2917580 8.44e-03 55_[+5(1.41e-05)]_17 chr9:123566701-123566781 3.86e-02 80 chr22:18968512-18968592 4.36e-01 80 chr6:28156060-28156140 1.82e-01 80 chr5:42988803-42988883 3.52e-01 80 chr22:42500515-42500595 2.31e-06 8_[+2(9.39e-06)]_8_[+1(1.34e-05)]_\ [+4(9.62e-06)]_40 chr4:1740314-1740394 1.78e-06 10_[+2(9.39e-06)]_11_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_34 chr1:23349779-23349859 7.20e-01 80 chr12:53575858-53575938 2.54e-01 80 chr5:150211601-150211681 1.10e-04 1_[+2(3.28e-05)]_71 chr6:35611586-35611666 4.51e-03 51_[+2(3.28e-05)]_21 chr2:112866969-112867049 2.99e-03 80 chr7:135949178-135949258 1.87e-02 64_[+4(7.88e-05)]_8 chr6:137491198-137491278 6.48e-01 80 chr5:150311124-150311204 2.81e-01 80 chr1:204492902-204492982 4.18e-04 12_[+4(9.62e-06)]_60 chr15:60568013-60568093 3.25e-01 80 chr8:146202715-146202795 1.92e-02 46_[+1(4.46e-05)]_26 chr20:52207325-52207405 7.63e-01 80 chr1:180557406-180557486 3.88e-05 38_[+1(1.34e-05)]_12_[+3(2.15e-05)]_\ 14 chr3:183161674-183161754 3.46e-03 59_[+3(2.15e-05)]_13 chr1:25962808-25962888 4.27e-01 80 chr15:68577141-68577221 2.33e-02 80 chr7:130016482-130016562 2.58e-01 80 chr4:38257305-38257385 1.17e-01 80 chr17:80698887-80698967 3.69e-01 80 chr18:11957067-11957147 3.32e-03 49_[+3(2.15e-05)]_23 chr1:46859244-46859324 7.89e-05 6_[+2(9.39e-06)]_16_[+4(9.62e-06)]_\ 42 chr12:133779267-13377934 6.50e-01 80 chr18:19773691-19773771 4.54e-02 30_[+2(9.39e-06)]_42 chr6:135805206-135805286 1.01e-01 80 chr7:66189123-66189203 1.32e-01 80 chr2:95815308-95815388 4.91e-02 66_[+1(4.46e-05)]_6 chr1:24205312-24205392 9.77e-01 80 chr22:22798156-22798236 5.95e-01 80 chr3:196483748-196483828 1.37e-04 35_[+2(9.39e-06)]_19_[+4(9.62e-06)]_\ 10 chr1:54308166-54308246 2.62e-01 80 chr7:5060914-5060994 7.92e-02 80 chr20:29633372-29633452 6.60e-01 80 chr8:86970377-86970457 1.45e-01 40_[+3(7.51e-05)]_32 chr7:129217979-129218059 3.02e-01 80 chr19:12138165-12138245 1.16e-03 37_[+1(2.26e-05)]_35 chr19:12637502-12637582 3.88e-01 80 chr17:37203395-37203475 2.29e-05 31_[+1(1.34e-05)]_11_[+3(2.15e-05)]_\ 22 chr6:27420425-27420505 7.32e-02 3_[+1(3.57e-05)]_69 chr15:43653643-43653723 5.00e-02 80 chr10:70231065-70231145 9.08e-01 80 chr2:238871259-238871339 2.19e-09 [+2(9.39e-06)]_10_[+1(1.34e-05)]_1_\ [+4(9.62e-06)]_12_[+3(8.42e-05)]_25 chr16:10588948-10589028 6.13e-03 55_[+3(2.15e-05)]_17 chr12:127643592-12764367 4.89e-01 80 chr7:138017737-138017817 5.53e-02 80 chr1:20486697-20486777 3.46e-03 14_[+4(5.34e-05)]_58 chr3:42956494-42956574 1.10e-01 80 chr17:48477189-48477269 1.30e-02 80 chr1:1348055-1348135 6.43e-01 80 chr3:33773949-33774029 4.77e-01 80 chr2:46486197-46486277 1.58e-01 80 chr10:52320599-52320679 1.88e-03 80 chr4:129186890-129186970 8.68e-01 80 chr19:53471215-53471295 9.78e-01 80 chr12:96738210-96738290 5.25e-02 80 chr7:65926556-65926636 7.18e-01 80 chr15:85164768-85164848 3.88e-03 8_[+5(1.41e-05)]_64 chr17:75170842-75170922 4.90e-06 36_[+2(9.39e-06)]_16_[+4(9.62e-06)]_\ 12 chr8:30004983-30005063 3.03e-03 10_[+5(2.37e-05)]_62 chr9:123567280-123567360 3.30e-02 56_[+2(5.29e-05)]_16 chr21:44420364-44420444 2.14e-01 80 chr22:38768858-38768938 3.28e-02 80 chr1:117286304-117286384 1.56e-03 55_[+3(2.15e-05)]_17 chr11:33953419-33953499 3.01e-04 38_[+2(9.39e-06)]_18_[+4(9.62e-06)]_\ 8 chr22:17132256-17132336 6.04e-02 17_[+4(7.88e-05)]_55 chr9:45699258-45699338 5.68e-01 80 chr12:57303390-57303470 1.29e-02 80 chr3:10287166-10287246 1.59e-05 15_[+1(1.34e-05)]_14_[+3(2.15e-05)]_\ 35 chr1:16919472-16919552 3.62e-01 80 chr1:205125243-205125323 1.12e-03 15_[+1(5.40e-05)]_57 chr16:70885265-70885345 5.52e-01 80 chr6:35397397-35397477 2.30e-06 15_[+2(9.39e-06)]_10_[+1(1.34e-05)]_\ 1_[+4(7.88e-05)]_30 chr19:44514777-44514857 5.47e-01 80 chr4:72729355-72729435 1.51e-04 28_[+5(4.74e-05)]_36_[+4(7.88e-05)] chr6:161645783-161645863 7.74e-01 80 chr11:63559430-63559510 7.77e-03 21_[+3(2.15e-05)]_51 chr5:171406732-171406812 7.87e-06 32_[+2(9.39e-06)]_13_[+1(1.34e-05)]_\ 1_[+4(4.65e-05)]_10 chr15:43420808-43420888 7.57e-02 80 chr7:107515624-107515704 3.06e-01 80 chr7:149408033-149408113 6.87e-01 80 chr9:99581032-99581112 3.95e-02 67_[+3(4.85e-05)]_5 chr7:152430498-152430578 1.67e-06 24_[+2(9.39e-06)]_10_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_21 chr2:55294185-55294265 9.95e-01 80 chr1:31931290-31931370 1.27e-05 32_[+1(1.34e-05)]_11_[+3(2.15e-05)]_\ 21 chr19:9752602-9752682 1.44e-02 80 chr7:149297601-149297681 1.14e-01 80 chr1:228430134-228430214 3.24e-02 9_[+2(6.63e-05)]_63 chr19:12053698-12053778 4.64e-02 80 chr22:23074568-23074648 6.73e-01 80 chr1:40928931-40929011 8.03e-01 80 chr7:159120923-159121003 4.09e-01 80 chr3:44683902-44683982 1.28e-03 10_[+5(1.41e-05)]_62 chr7:106706427-106706507 5.37e-01 80 chr10:73715400-73715480 9.21e-01 80 chr7:106645520-106645600 2.88e-01 80 chr1:63109222-63109302 1.75e-01 80 chr7:156513681-156513761 5.55e-01 80 chr16:3274045-3274125 1.77e-01 80 chr19:35668434-35668514 2.65e-01 80 chr13:90449786-90449866 2.05e-01 80 chr2:122440528-122440608 1.55e-06 25_[+2(9.39e-06)]_11_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_19 chr8:195497-195577 2.94e-02 31_[+5(1.41e-05)]_41 chr3:48655171-48655251 2.12e-07 17_[+2(9.39e-06)]_10_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_28 chr1:15168614-15168694 1.72e-01 80 chr16:72707205-72707285 5.06e-01 80 chr15:80208269-80208349 2.15e-06 27_[+2(9.39e-06)]_10_[+1(1.34e-05)]_\ 1_[+4(9.62e-06)]_18 chr1:46704678-46704758 1.93e-01 80 chr2:171780436-171780516 2.67e-01 80 chr22:25112709-25112789 2.61e-05 38_[+1(1.34e-05)]_12_[+3(6.25e-06)]_\ 14 chr6:135803053-135803133 4.68e-01 80 chr1:160955643-160955723 8.26e-03 30_[+4(1.95e-05)]_42 chr19:14829501-14829581 2.92e-02 [+5(1.41e-05)]_72 chr1:16871889-16871969 2.14e-01 80 chr1:211867403-211867483 3.03e-02 47_[+4(5.34e-05)]_25 chr6:30837191-30837271 1.18e-01 80 chr9:115759549-115759629 2.11e-01 80 chr19:44536386-44536466 5.96e-03 56_[+5(1.41e-05)]_16 chr1:244739764-244739844 2.13e-05 30_[+1(1.34e-05)]_11_[+3(2.15e-05)]_\ 23 chr16:89064293-89064373 8.76e-01 80 chr6:27111203-27111283 2.86e-01 80 chr15:80212641-80212721 1.49e-04 8_[+4(9.62e-06)]_64 chr3:143276964-143277044 1.81e-01 12_[+5(6.15e-05)]_60 chr1:1467470-1467550 4.71e-02 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n06.farnam.hpc.yale.internal ********************************************************************************