******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/SP1.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr12:132166841-13216692 1.0000 80 chr16:87594452-87594532 1.0000 80 chr1:228361809-228361889 1.0000 80 chr13:114428165-11442824 1.0000 80 chr9:129987436-129987516 1.0000 80 chr7:155610381-155610461 1.0000 80 chr16:22202005-22202085 1.0000 80 chr8:143858985-143859065 1.0000 80 chr1:228362161-228362241 1.0000 80 chr21:46825455-46825535 1.0000 80 chrX:1571976-1572056 1.0000 80 chr6:170475741-170475821 1.0000 80 chr6:169825686-169825766 1.0000 80 chr22:44588444-44588524 1.0000 80 chr19:4310846-4310926 1.0000 80 chr7:6543427-6543507 1.0000 80 chr16:84047811-84047891 1.0000 80 chr21:45848412-45848492 1.0000 80 chr3:128840883-128840963 1.0000 80 chr19:8657396-8657476 1.0000 80 chr19:50143574-50143654 1.0000 80 chr19:1123168-1123248 1.0000 80 chr16:89653354-89653434 1.0000 80 chr19:49866861-49866941 1.0000 80 chr6:37137819-37137899 1.0000 80 chr10:28592013-28592093 1.0000 80 chr2:17699717-17699797 1.0000 80 chr17:76136615-76136695 1.0000 80 chr2:220417395-220417475 1.0000 80 chrX:15756226-15756306 1.0000 80 chr19:6678073-6678153 1.0000 80 chrX:153042287-153042367 1.0000 80 chr20:62184746-62184826 1.0000 80 chr1:226033494-226033574 1.0000 80 chr21:37528801-37528881 1.0000 80 chr10:48354863-48354943 1.0000 80 chr1:227976204-227976284 1.0000 80 chr9:139916637-139916717 1.0000 80 chr1:33647678-33647758 1.0000 80 chr19:12951512-12951592 1.0000 80 chr7:43622567-43622647 1.0000 80 chr20:61425853-61425933 1.0000 80 chr16:517788-517868 1.0000 80 chr1:175162067-175162147 1.0000 80 chr1:2517973-2518053 1.0000 80 chr19:3574021-3574101 1.0000 80 chr19:1063082-1063162 1.0000 80 chr19:49363467-49363547 1.0000 80 chr10:134093648-13409372 1.0000 80 chr19:7935738-7935818 1.0000 80 chr9:140044948-140045028 1.0000 80 chr1:2126416-2126496 1.0000 80 chr1:994949-995029 1.0000 80 chr19:18747472-18747552 1.0000 80 chr7:25902185-25902265 1.0000 80 chr16:1393173-1393253 1.0000 80 chr19:7670529-7670609 1.0000 80 chr17:75277598-75277678 1.0000 80 chr19:55038334-55038414 1.0000 80 chr19:4556343-4556423 1.0000 80 chr3:38066579-38066659 1.0000 80 chr7:130756967-130757047 1.0000 80 chr16:28947997-28948077 1.0000 80 chr9:130981128-130981208 1.0000 80 chr19:10981885-10981965 1.0000 80 chr13:114429472-11442955 1.0000 80 chr19:36266323-36266403 1.0000 80 chr3:160116994-160117074 1.0000 80 chr1:1850856-1850936 1.0000 80 chrX:53711218-53711298 1.0000 80 chr19:6767595-6767675 1.0000 80 chr2:54483398-54483478 1.0000 80 chr1:231473942-231474022 1.0000 80 chr19:38997754-38997834 1.0000 80 chr17:4843528-4843608 1.0000 80 chr4:37688158-37688238 1.0000 80 chr7:44788255-44788335 1.0000 80 chr19:11616031-11616111 1.0000 80 chr15:34880670-34880750 1.0000 80 chr4:3076179-3076259 1.0000 80 chr16:84048017-84048097 1.0000 80 chr19:56135832-56135912 1.0000 80 chr16:2955904-2955984 1.0000 80 chr11:134314449-13431452 1.0000 80 chr1:41826839-41826919 1.0000 80 chr1:31191051-31191131 1.0000 80 chr19:9929873-9929953 1.0000 80 chr16:81130086-81130166 1.0000 80 chr12:49351290-49351370 1.0000 80 chr19:1490880-1490960 1.0000 80 chr2:242823872-242823952 1.0000 80 chr6:97731134-97731214 1.0000 80 chr1:21934437-21934517 1.0000 80 chr19:5687003-5687083 1.0000 80 chrX:153607311-153607391 1.0000 80 chr20:32581203-32581283 1.0000 80 chr9:130533677-130533757 1.0000 80 chr22:19166343-19166423 1.0000 80 chr14:100705088-10070516 1.0000 80 chr16:89768425-89768505 1.0000 80 chr5:114505661-114505741 1.0000 80 chr1:1229236-1229316 1.0000 80 chr4:103749178-103749258 1.0000 80 chr15:44580889-44580969 1.0000 80 chr22:36784154-36784234 1.0000 80 chr19:47931553-47931633 1.0000 80 chr17:7760868-7760948 1.0000 80 chr11:119773602-11977368 1.0000 80 chr16:2186121-2186201 1.0000 80 chr19:7985165-7985245 1.0000 80 chr14:30766263-30766343 1.0000 80 chr9:88555889-88555969 1.0000 80 chr19:1455699-1455779 1.0000 80 chr6:167040932-167041012 1.0000 80 chr19:40971802-40971882 1.0000 80 chr17:4167251-4167331 1.0000 80 chr11:1285835-1285915 1.0000 80 chr17:79093576-79093656 1.0000 80 chr17:4900942-4901022 1.0000 80 chr7:72847974-72848054 1.0000 80 chr6:30658712-30658792 1.0000 80 chr12:29534133-29534213 1.0000 80 chr19:17320597-17320677 1.0000 80 chr7:138144729-138144809 1.0000 80 chr4:2845305-2845385 1.0000 80 chr10:3215384-3215464 1.0000 80 chr19:2900719-2900799 1.0000 80 chr19:47760470-47760550 1.0000 80 chr19:5904594-5904674 1.0000 80 chr12:122277467-12227754 1.0000 80 chr16:1993353-1993433 1.0000 80 chr11:67764410-67764490 1.0000 80 chr19:8590619-8590699 1.0000 80 chr19:9945797-9945877 1.0000 80 chr19:10946382-10946462 1.0000 80 chrX:48660186-48660266 1.0000 80 chr22:42896211-42896291 1.0000 80 chr19:47950875-47950955 1.0000 80 chr19:39436129-39436209 1.0000 80 chr19:18633081-18633161 1.0000 80 chr4:4674905-4674985 1.0000 80 chr17:53046026-53046106 1.0000 80 chr16:57769533-57769613 1.0000 80 chr7:99775083-99775163 1.0000 80 chr1:160068396-160068476 1.0000 80 chr11:13484820-13484900 1.0000 80 chr9:99212297-99212377 1.0000 80 chr19:1082572-1082652 1.0000 80 chr20:60813321-60813401 1.0000 80 chr19:17690766-17690846 1.0000 80 chr19:1045387-1045467 1.0000 80 chr8:144302021-144302101 1.0000 80 chr19:41076674-41076754 1.0000 80 chr7:157100650-157100730 1.0000 80 chr3:49131521-49131601 1.0000 80 chr1:207226305-207226385 1.0000 80 chr19:18315031-18315111 1.0000 80 chrX:109244182-109244262 1.0000 80 chr4:6597797-6597877 1.0000 80 chr19:47164580-47164660 1.0000 80 chr1:232941064-232941144 1.0000 80 chr16:27879170-27879250 1.0000 80 chr19:8115582-8115662 1.0000 80 chr11:67573297-67573377 1.0000 80 chr6:146285553-146285633 1.0000 80 chr1:206138164-206138244 1.0000 80 chr7:72298865-72298945 1.0000 80 chr16:29888907-29888987 1.0000 80 chr19:51870879-51870959 1.0000 80 chr16:5148160-5148240 1.0000 80 chr2:97202327-97202407 1.0000 80 chr7:20837955-20838035 1.0000 80 chr10:104677948-10467802 1.0000 80 chr16:87526651-87526731 1.0000 80 chr10:135186890-13518697 1.0000 80 chr9:139237362-139237442 1.0000 80 chr5:34929452-34929532 1.0000 80 chr1:245508946-245509026 1.0000 80 chr12:57940967-57941047 1.0000 80 chr15:69452838-69452918 1.0000 80 chr11:65641087-65641167 1.0000 80 chr19:3285251-3285331 1.0000 80 chr19:10403091-10403171 1.0000 80 chr6:147981709-147981789 1.0000 80 chr1:228247619-228247699 1.0000 80 chr5:176853453-176853533 1.0000 80 chr16:87985036-87985116 1.0000 80 chr22:35627075-35627155 1.0000 80 chr4:148605219-148605299 1.0000 80 chr19:48111962-48112042 1.0000 80 chr9:130159195-130159275 1.0000 80 chr12:27091337-27091417 1.0000 80 chr19:4124139-4124219 1.0000 80 chr17:40075316-40075396 1.0000 80 chr15:78730396-78730476 1.0000 80 chr2:232759818-232759898 1.0000 80 chrX:30907511-30907591 1.0000 80 chr19:4328494-4328574 1.0000 80 chr8:124428714-124428794 1.0000 80 chr6:52284958-52285038 1.0000 80 chr7:139677139-139677219 1.0000 80 chr19:50249576-50249656 1.0000 80 chr14:29299352-29299432 1.0000 80 chr5:125849880-125849960 1.0000 80 chr19:55538648-55538728 1.0000 80 chr1:3817918-3817998 1.0000 80 chr10:7830014-7830094 1.0000 80 chr19:48996279-48996359 1.0000 80 chr1:207224334-207224414 1.0000 80 chr19:41304803-41304883 1.0000 80 chr16:2479199-2479279 1.0000 80 chrX:13752710-13752790 1.0000 80 chr16:30411986-30412066 1.0000 80 chr19:36505247-36505327 1.0000 80 chr2:136743187-136743267 1.0000 80 chr19:889065-889145 1.0000 80 chr19:17443594-17443674 1.0000 80 chr2:219773773-219773853 1.0000 80 chr1:2064713-2064793 1.0000 80 chr15:72410535-72410615 1.0000 80 chr12:131153973-13115405 1.0000 80 chr19:19729572-19729652 1.0000 80 chr11:1283954-1284034 1.0000 80 chr15:45571501-45571581 1.0000 80 chr19:45394284-45394364 1.0000 80 chr19:16739129-16739209 1.0000 80 chr17:79980926-79981006 1.0000 80 chr8:103251460-103251540 1.0000 80 chr9:140353824-140353904 1.0000 80 chr11:5526911-5526991 1.0000 80 chr18:75705700-75705780 1.0000 80 chr10:127408093-12740817 1.0000 80 chr16:20956640-20956720 1.0000 80 chr19:11457106-11457186 1.0000 80 chr5:169010699-169010779 1.0000 80 chr8:145596549-145596629 1.0000 80 chr16:54963156-54963236 1.0000 80 chr19:14629428-14629508 1.0000 80 chr14:104181913-10418199 1.0000 80 chr12:50561239-50561319 1.0000 80 chr1:145516258-145516338 1.0000 80 chr19:33166125-33166205 1.0000 80 chr19:17650634-17650714 1.0000 80 chr12:113659032-11365911 1.0000 80 chr10:102820514-10282059 1.0000 80 chr19:3914382-3914462 1.0000 80 chr21:47673702-47673782 1.0000 80 chr11:72525255-72525335 1.0000 80 chr8:12051766-12051846 1.0000 80 chr20:35064801-35064881 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_SP1/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/SP1.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.173 C 0.33 G 0.328 T 0.17 Background letter frequencies (from file dataset with add-one prior applied): A 0.173 C 0.33 G 0.328 T 0.17 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TCTCGCGA MEME-1 width = 8 sites = 49 llr = 477 E-value = 1.0e-045 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCTCGCGA MEME-1 Description -------------------------------------------------------------------------------- Simplified A :1:::::a pos.-specific C :9:a:7:: probability G ::::a:a: matrix T a:a::2:: bits 2.6 * * 2.3 * * * 2.0 * * * 1.8 * * * Relative 1.5 * ** ** Entropy 1.3 ***** ** (14.0 bits) 1.0 ***** ** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel TCTCGCGA consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCTCGCGA MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr10:102820514-10282059 19 1.93e-05 CTGTTCTGAT TCTCGCGA CAGTTGCGAG chr12:131153973-13115405 49 1.93e-05 cccgtgctgt tctcgcga gagtgaggaa chr16:30411986-30412066 52 1.93e-05 CTGGACGGGT TCTCGCGA GATCGTAAGC chrX:13752710-13752790 47 1.93e-05 TGGGATGTGC TCTCGCGA TACGTAGGCG chrX:30907511-30907591 54 1.93e-05 CCCAGGGCGA TCTCGCGA GGCTTCCCCC chr2:232759818-232759898 39 1.93e-05 gtgagtgcat tctcgcga gatctgctca chr19:4124139-4124219 23 1.93e-05 CGGACCGGCT TCTCGCGA TAACGGGATC chr12:27091337-27091417 52 1.93e-05 AGGAAAGAAA TCTCGCGA GGCTGGAGTT chr16:87985036-87985116 18 1.93e-05 CGGCGGCTTC TCTCGCGA GGACGGACGC chr6:147981709-147981789 59 1.93e-05 ccctcgctgt tctcgcga tagtgagaga chr12:57940967-57941047 8 1.93e-05 CAGGAAG TCTCGCGA CAGCAGTAGC chr6:146285553-146285633 58 1.93e-05 TACAGTGGAG TCTCGCGA TAGCTCTGCC chr16:27879170-27879250 65 1.93e-05 TCCTTGCGTT TCTCGCGA GACCAGGC chr1:232941064-232941144 22 1.93e-05 CTTCCGCAAA TCTCGCGA GATAGCAGGC chr1:207226305-207226385 23 1.93e-05 AATAGTCTAC TCTCGCGA GAGTCAGAAA chr11:13484820-13484900 41 1.93e-05 CCAGCAGCGT TCTCGCGA GAACGGTGCT chr17:53046026-53046106 49 1.93e-05 GCGTGCTCCG TCTCGCGA GATCTGGGTT chr12:29534133-29534213 50 1.93e-05 AATGTACAGA TCTCGCGA TATTCCCTTT chr17:4167251-4167331 62 1.93e-05 AATCACCAAG TCTCGCGA GAATCGCGGG chr9:88555889-88555969 48 1.93e-05 TCGTCTCTAA TCTCGCGA GAAGAGAAGG chr17:7760868-7760948 59 1.93e-05 ACGGCACAGA TCTCGCGA GCTTCTCCTA chr4:103749178-103749258 50 1.93e-05 ATGCATAAGT TCTCGCGA GACGCAGTAA chr14:100705088-10070516 68 1.93e-05 AGCGCGGAAG TCTCGCGA GGCCG chr6:97731134-97731214 38 1.93e-05 CCCCACGAAT TCTCGCGA GAGTCCGTCA chr12:49351290-49351370 58 1.93e-05 TAGCGGCAGT TCTCGCGA GACCCATCAC chr17:4843528-4843608 26 1.93e-05 GTTGGAGCGC TCTCGCGA TAGACACAGC chr2:54483398-54483478 52 1.93e-05 CActcctcag tctcgcga gtctgtggtg chr19:55038334-55038414 35 1.93e-05 AGACCCGTCG TCTCGCGA AATCTTCACC chr5:169010699-169010779 23 2.93e-05 TGGGCGGACG TCTCGTGA GACGTGGGAC chr18:75705700-75705780 19 2.93e-05 aaccatcaga tctcgtga gacccattca chr11:5526911-5526991 11 2.93e-05 aaccatcaga tctcgtga gacccattca chr7:139677139-139677219 30 2.93e-05 aaccatcaga tctcgtga gacttactca chr22:35627075-35627155 16 2.93e-05 aaccatcaga tctcgtga gaactcactc chr1:245508946-245509026 48 2.93e-05 gtgagtgagt tctcgtga gatctggttg chr11:1285835-1285915 21 2.93e-05 aaccaccaga tctcgtga gaattcactc chr14:30766263-30766343 23 2.93e-05 aacaaccaga tctcgtga gaactcacgc chr11:119773602-11977368 33 2.93e-05 acccatcaga tctcgtga gacttattca chr11:134314449-13431452 52 2.93e-05 aaccaccaga tctcgtga gacttactca chr2:219773773-219773853 27 3.94e-05 GAAGACGCGC TATCGCGA GATCGGTGGG chr1:207224334-207224414 68 3.94e-05 TGGTTGCAGT TATCGCGA CGCTT chr14:29299352-29299432 42 3.94e-05 tggagtgcag tatcgcga tatcggttcg chr15:34880670-34880750 42 3.94e-05 actcacccac tatcgcga gaacagcctg chrX:53711218-53711298 23 3.94e-05 AAACATGAGA TATCGCGA GACCTGGTGC chr2:136743187-136743267 27 5.48e-05 GCTGCGGCTA TCTCGAGA TCCCGGAGCG chr1:231473942-231474022 69 5.48e-05 TGACGGGCCG TCTCGAGA GCCG chr21:47673702-47673782 28 7.02e-05 cccttgctgt tctcatga aagtgagcct chr19:3914382-3914462 3 7.02e-05 ga tctcatga gacttactca chr3:49131521-49131601 24 1.13e-04 GGGCGTCGGA TCCCGCGA GATCTGGGAC chr3:160116994-160117074 33 1.13e-04 CCCTTCCTCT TCCCGCGA TACTTCTACG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCTCGCGA MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr10:102820514-10282059 1.9e-05 18_[+1]_54 chr12:131153973-13115405 1.9e-05 48_[+1]_24 chr16:30411986-30412066 1.9e-05 51_[+1]_21 chrX:13752710-13752790 1.9e-05 46_[+1]_26 chrX:30907511-30907591 1.9e-05 53_[+1]_19 chr2:232759818-232759898 1.9e-05 38_[+1]_34 chr19:4124139-4124219 1.9e-05 22_[+1]_50 chr12:27091337-27091417 1.9e-05 51_[+1]_21 chr16:87985036-87985116 1.9e-05 17_[+1]_55 chr6:147981709-147981789 1.9e-05 58_[+1]_14 chr12:57940967-57941047 1.9e-05 7_[+1]_65 chr6:146285553-146285633 1.9e-05 57_[+1]_15 chr16:27879170-27879250 1.9e-05 64_[+1]_8 chr1:232941064-232941144 1.9e-05 21_[+1]_51 chr1:207226305-207226385 1.9e-05 22_[+1]_50 chr11:13484820-13484900 1.9e-05 40_[+1]_32 chr17:53046026-53046106 1.9e-05 48_[+1]_24 chr12:29534133-29534213 1.9e-05 49_[+1]_23 chr17:4167251-4167331 1.9e-05 61_[+1]_11 chr9:88555889-88555969 1.9e-05 47_[+1]_25 chr17:7760868-7760948 1.9e-05 58_[+1]_14 chr4:103749178-103749258 1.9e-05 49_[+1]_23 chr14:100705088-10070516 1.9e-05 67_[+1]_5 chr6:97731134-97731214 1.9e-05 37_[+1]_35 chr12:49351290-49351370 1.9e-05 57_[+1]_15 chr17:4843528-4843608 1.9e-05 25_[+1]_47 chr2:54483398-54483478 1.9e-05 51_[+1]_21 chr19:55038334-55038414 1.9e-05 34_[+1]_38 chr5:169010699-169010779 2.9e-05 22_[+1]_50 chr18:75705700-75705780 2.9e-05 18_[+1]_54 chr11:5526911-5526991 2.9e-05 10_[+1]_62 chr7:139677139-139677219 2.9e-05 29_[+1]_43 chr22:35627075-35627155 2.9e-05 15_[+1]_57 chr1:245508946-245509026 2.9e-05 47_[+1]_25 chr11:1285835-1285915 2.9e-05 20_[+1]_52 chr14:30766263-30766343 2.9e-05 22_[+1]_50 chr11:119773602-11977368 2.9e-05 32_[+1]_40 chr11:134314449-13431452 2.9e-05 51_[+1]_21 chr2:219773773-219773853 3.9e-05 26_[+1]_46 chr1:207224334-207224414 3.9e-05 67_[+1]_5 chr14:29299352-29299432 3.9e-05 41_[+1]_31 chr15:34880670-34880750 3.9e-05 41_[+1]_31 chrX:53711218-53711298 3.9e-05 22_[+1]_50 chr2:136743187-136743267 5.5e-05 26_[+1]_46 chr1:231473942-231474022 5.5e-05 68_[+1]_4 chr21:47673702-47673782 7e-05 27_[+1]_45 chr19:3914382-3914462 7e-05 2_[+1]_70 chr3:49131521-49131601 0.00011 23_[+1]_49 chr3:160116994-160117074 0.00011 32_[+1]_40 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCTCGCGA MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCTCGCGA width=8 seqs=49 chr10:102820514-10282059 ( 19) TCTCGCGA 1 chr12:131153973-13115405 ( 49) TCTCGCGA 1 chr16:30411986-30412066 ( 52) TCTCGCGA 1 chrX:13752710-13752790 ( 47) TCTCGCGA 1 chrX:30907511-30907591 ( 54) TCTCGCGA 1 chr2:232759818-232759898 ( 39) TCTCGCGA 1 chr19:4124139-4124219 ( 23) TCTCGCGA 1 chr12:27091337-27091417 ( 52) TCTCGCGA 1 chr16:87985036-87985116 ( 18) TCTCGCGA 1 chr6:147981709-147981789 ( 59) TCTCGCGA 1 chr12:57940967-57941047 ( 8) TCTCGCGA 1 chr6:146285553-146285633 ( 58) TCTCGCGA 1 chr16:27879170-27879250 ( 65) TCTCGCGA 1 chr1:232941064-232941144 ( 22) TCTCGCGA 1 chr1:207226305-207226385 ( 23) TCTCGCGA 1 chr11:13484820-13484900 ( 41) TCTCGCGA 1 chr17:53046026-53046106 ( 49) TCTCGCGA 1 chr12:29534133-29534213 ( 50) TCTCGCGA 1 chr17:4167251-4167331 ( 62) TCTCGCGA 1 chr9:88555889-88555969 ( 48) TCTCGCGA 1 chr17:7760868-7760948 ( 59) TCTCGCGA 1 chr4:103749178-103749258 ( 50) TCTCGCGA 1 chr14:100705088-10070516 ( 68) TCTCGCGA 1 chr6:97731134-97731214 ( 38) TCTCGCGA 1 chr12:49351290-49351370 ( 58) TCTCGCGA 1 chr17:4843528-4843608 ( 26) TCTCGCGA 1 chr2:54483398-54483478 ( 52) TCTCGCGA 1 chr19:55038334-55038414 ( 35) TCTCGCGA 1 chr5:169010699-169010779 ( 23) TCTCGTGA 1 chr18:75705700-75705780 ( 19) TCTCGTGA 1 chr11:5526911-5526991 ( 11) TCTCGTGA 1 chr7:139677139-139677219 ( 30) TCTCGTGA 1 chr22:35627075-35627155 ( 16) TCTCGTGA 1 chr1:245508946-245509026 ( 48) TCTCGTGA 1 chr11:1285835-1285915 ( 21) TCTCGTGA 1 chr14:30766263-30766343 ( 23) TCTCGTGA 1 chr11:119773602-11977368 ( 33) TCTCGTGA 1 chr11:134314449-13431452 ( 52) TCTCGTGA 1 chr2:219773773-219773853 ( 27) TATCGCGA 1 chr1:207224334-207224414 ( 68) TATCGCGA 1 chr14:29299352-29299432 ( 42) TATCGCGA 1 chr15:34880670-34880750 ( 42) TATCGCGA 1 chrX:53711218-53711298 ( 23) TATCGCGA 1 chr2:136743187-136743267 ( 27) TCTCGAGA 1 chr1:231473942-231474022 ( 69) TCTCGAGA 1 chr21:47673702-47673782 ( 28) TCTCATGA 1 chr19:3914382-3914462 ( 3) TCTCATGA 1 chr3:49131521-49131601 ( 24) TCCCGCGA 1 chr3:160116994-160117074 ( 33) TCCCGCGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCTCGCGA MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.65557 E= 1.0e-045 -1226 -1226 -1226 256 -76 145 -1226 -1226 -1226 -301 -1226 250 -1226 160 -1226 -1226 -208 -1226 155 -1226 -208 112 -1226 53 -1226 -1226 161 -1226 253 -1226 -1226 -1226 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCTCGCGA MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 49 E= 1.0e-045 0.000000 0.000000 0.000000 1.000000 0.102041 0.897959 0.000000 0.000000 0.000000 0.040816 0.000000 0.959184 0.000000 1.000000 0.000000 0.000000 0.040816 0.000000 0.959184 0.000000 0.040816 0.714286 0.000000 0.244898 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCTCGCGA MEME-1 regular expression -------------------------------------------------------------------------------- TCTCG[CT]GA -------------------------------------------------------------------------------- Time 4.86 secs. ******************************************************************************** ******************************************************************************** MOTIF GGCGGGGC MEME-2 width = 8 sites = 79 llr = 583 E-value = 1.1e-018 ******************************************************************************** -------------------------------------------------------------------------------- Motif GGCGGGGC MEME-2 Description -------------------------------------------------------------------------------- Simplified A ::1::2:1 pos.-specific C ::7::::9 probability G aa:a88a: matrix T ::2:2::: bits 2.6 2.3 2.0 1.8 Relative 1.5 ** * * Entropy 1.3 ** * ** (10.6 bits) 1.0 ** ***** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel GGCGGGGC consensus A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGGGC MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:17650634-17650714 60 1.36e-04 GTCAGAGAGG GGCGGGGC CAAGCATAGG chr19:36505247-36505327 62 1.36e-04 GGAGGGCGTG GGCGGGGC ATCGTCGTCT chr19:48111962-48112042 56 1.36e-04 CGCTCGGCCT GGCGGGGC CGGGGCTGGT chr19:10403091-10403171 16 1.36e-04 TGGCCCGAGG GGCGGGGC AGGTGGGGGC chr11:65641087-65641167 34 1.36e-04 GCGGAGTATG GGCGGGGC TGGCTCCCAG chr11:67573297-67573377 11 1.36e-04 GCGGGGCCAG GGCGGGGC GTTGACTATG chr19:18315031-18315111 47 1.36e-04 GCCTCGGGGA GGCGGGGC CCCTCAGCGT chr19:1045387-1045467 19 1.36e-04 GCCCGTGATG GGCGGGGC CTAGGTGCAT chr20:60813321-60813401 68 1.36e-04 CCGCTGCGTG GGCGGGGC TCTGA chr19:1082572-1082652 29 1.36e-04 GTACCTGCAG GGCGGGGC GCGCGTGGCC chr19:9945797-9945877 11 1.36e-04 GCTGGCCGGG GGCGGGGC GCAGGGATAA chr19:47760470-47760550 51 1.36e-04 GCCAATCGGA GGCGGGGC CAGAGGGTTG chr7:138144729-138144809 50 1.36e-04 GTCCGGAGGG GGCGGGGC TGGGCAAGCA chr19:17320597-17320677 36 1.36e-04 GGTCTTGGTG GGCGGGGC CTTGGGTGGG chr19:40971802-40971882 47 1.36e-04 TAGACTGGAA GGCGGGGC CACAGAAGGC chr5:114505661-114505741 48 1.36e-04 GCACAAAAGA GGCGGGGC CGCCTGGGGC chr14:100705088-10070516 39 1.36e-04 GTGGCAGCGA GGCGGGGC GGGCTGAGGC chr22:19166343-19166423 69 1.36e-04 CAGGCGTAGG GGCGGGGC CAAA chr19:9929873-9929953 44 1.36e-04 gaggatcgga ggcggggc tagagacggg chr16:2955904-2955984 42 1.36e-04 GGTACCAATG GGCGGGGC TGAACCAATG chr19:11616031-11616111 17 1.36e-04 AGTTCTAGCG GGCGGGGC CAAGCGCTCA chr19:38997754-38997834 1 1.36e-04 . GGCGGGGC CAGATGGGGA chr19:10981885-10981965 51 1.36e-04 CCGGCCTGGG GGCGGGGC CCAGGCCTCC chr3:38066579-38066659 46 1.36e-04 GCAGCCCGGG GGCGGGGC CAGGGCCCAG chr1:33647678-33647758 64 1.36e-04 GCGGGGGAGG GGCGGGGC CACCAGCCG chr19:6678073-6678153 43 1.36e-04 GCGTGGCATG GGCGGGGC AGTCGGGCGG chr2:220417395-220417475 52 1.36e-04 GCGTGAGCGG GGCGGGGC AGAGGGCAGT chr17:76136615-76136695 3 1.36e-04 GG GGCGGGGC CCTTGGAGGT chr10:28592013-28592093 26 1.36e-04 GGAGGGGCGG GGCGGGGC TGCACCGCCC chr19:50143574-50143654 2 1.36e-04 A GGCGGGGC TATGCTAATG chr9:129987436-129987516 32 1.36e-04 gcggcgccgg ggcggggC CTGGGCCCAG chr14:104181913-10418199 9 2.77e-04 CTGAGAGG GGCGGAGC GTACCCGGGC chr16:54963156-54963236 5 2.77e-04 AGGG GGCGGAGC CCAGGGAGGC chrX:13752710-13752790 61 2.77e-04 GCGATACGTA GGCGGAGC TTCCGGCCGG chr1:228247619-228247699 35 2.77e-04 GCTCCCTGAG GGCGGAGC GCCTCCTTAG chr16:57769533-57769613 62 2.77e-04 CCTGGCAGGA GGCGGAGC ACCCGCGGCA chr22:42896211-42896291 8 2.77e-04 CCTGGCA GGTGGGGC GGAGGCCTTC chr12:122277467-12227754 38 2.77e-04 GGTCAGTGTG GGCGGAGC CTTGGGGGCC chr10:3215384-3215464 34 2.77e-04 TGCTGTGTTG GGTGGGGC TGTGCAAGTG chr19:1455699-1455779 70 2.77e-04 TCAGCAGGTG GGTGGGGC CTA chr16:2186121-2186201 2 2.77e-04 G GGCGGAGC GTCTGGAAGC chr22:36784154-36784234 49 2.77e-04 AAAGGGGGTG GGCGGAGC CTCTGCGGCC chr16:89768425-89768505 32 2.77e-04 TCCCCTGGGG GGTGGGGC CACCGGCATT chr4:3076179-3076259 32 2.77e-04 CCTTCGCCCG GGTGGGGC GCTGCGCTGT chrX:53711218-53711298 61 2.77e-04 AAAGGAGAAA GGCGGAGC TTCATGAAAA chr19:36266323-36266403 25 2.77e-04 TAAGGCCAAG GGCGGAGC CAATGAGAAG chr19:4556343-4556423 64 2.77e-04 GGCCGATTGG GGTGGGGC ATGGTCGTG chr7:25902185-25902265 64 2.77e-04 ACGAGGAAGA GGCGGAGC GGGCCGAGG chr20:61425853-61425933 27 2.77e-04 cccgccccgc GGTGGGGC CTCCGCAGCG chr16:87594452-87594532 3 2.77e-04 GG GGTGGGGC CAGGCCTCCT chr12:132166841-13216692 44 2.77e-04 GCGGGGAAGA GGTGGGGC CCAGACTGGG chr9:139237362-139237442 2 3.47e-04 G GGCGTGGC CTTGCTGTTG chr19:5904594-5904674 59 3.47e-04 CCAGCCTGGG GGCGTGGC TGTCAAGATC chr1:994949-995029 62 3.47e-04 AAGGCCGGGG GGCGTGGC CTCGGGGCGT chr9:139916637-139916717 26 3.47e-04 AGAGAGTGGG GGCGTGGC TCAGATGGTG chr19:1123168-1123248 23 3.47e-04 GCGGGTCATG GGCGTGGC CAGGAATGCC chr19:8657396-8657476 68 3.47e-04 ATAGACGGTG GGCGTGGC CAACG chr6:170475741-170475821 9 3.47e-04 cttccggg ggcgtggc caggcaggtg chr1:228362161-228362241 10 3.47e-04 ctcgctgtg ggcgtggc tcgctgtggg chr8:145596549-145596629 65 4.18e-04 GGTGGGAGGA GGAGGGGC CACTGGTG chr19:45394284-45394364 36 4.18e-04 GGGAAGGGTG GGAGGGGC GCCGTGGCTA chr6:147981709-147981789 2 4.18e-04 a ggaggggc ctggtacaaa chr19:39436129-39436209 56 4.18e-04 AGAGCCTCGG GGAGGGGC CTGGGTGGTC chr19:4310846-4310926 58 4.55e-04 CCCGCCCTGG GGTGGAGC CATGAGAAGG chr4:6597797-6597877 30 5.28e-04 AGTCAAGTTG GGTGTGGC TCTGTCCAGG chr19:41076674-41076754 41 5.28e-04 CTGAGGAGGG GGTGTGGC TCAACTTCAG chr4:37688158-37688238 66 5.28e-04 CAGCCTCAGC GGCGTAGC TAGGCCA chrX:15756226-15756306 7 5.28e-04 TAAAGG GGTGTGGC CAGGGTGGAG chr21:45848412-45848492 65 5.28e-04 CCTCCCCTTA GGTGTGGC TCCTCCCC chr20:35064801-35064881 24 5.66e-04 TTGCTCCCTG GGAGGAGC CCTGCATTAA chr19:47931553-47931633 6 5.66e-04 CAAGT GGAGGAGC TTGGCTGATG chr16:84048017-84048097 55 5.66e-04 CAGAGTCGAG GGAGGAGC TGTATAGCCA chr20:62184746-62184826 47 5.66e-04 GCCTGCGCTG GGAGGAGC CTGTGGTGGG chr2:242823872-242823952 24 6.03e-04 CTGGGCTAGA GGAGTGGC CCTGTGTGCG chr22:44588444-44588524 55 6.03e-04 TGCCCTCTGG GGAGTGGC CATCCTACCT chr12:113659032-11365911 14 6.93e-04 CAACGAGTAA GGCGGGGA ACAAGGGAGG chr15:45571501-45571581 47 6.93e-04 CCGCCCTGGA GGCGGGGA AAACACGCCC chr16:2479199-2479279 60 6.93e-04 TCCCGGAGCA GGCGGGGA GGGCGTGGAG chr16:28947997-28948077 47 6.93e-04 CCGCCCCCGG GGCGGGGA GTCCCGCCCA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGGGC MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:17650634-17650714 0.00014 59_[+2]_13 chr19:36505247-36505327 0.00014 61_[+2]_11 chr19:48111962-48112042 0.00014 55_[+2]_17 chr19:10403091-10403171 0.00014 15_[+2]_57 chr11:65641087-65641167 0.00014 33_[+2]_39 chr11:67573297-67573377 0.00014 10_[+2]_62 chr19:18315031-18315111 0.00014 46_[+2]_26 chr19:1045387-1045467 0.00014 18_[+2]_54 chr20:60813321-60813401 0.00014 67_[+2]_5 chr19:1082572-1082652 0.00014 28_[+2]_44 chr19:9945797-9945877 0.00014 10_[+2]_62 chr19:47760470-47760550 0.00014 50_[+2]_22 chr7:138144729-138144809 0.00014 49_[+2]_23 chr19:17320597-17320677 0.00014 35_[+2]_37 chr19:40971802-40971882 0.00014 46_[+2]_26 chr5:114505661-114505741 0.00014 47_[+2]_25 chr14:100705088-10070516 0.00014 38_[+2]_34 chr22:19166343-19166423 0.00014 68_[+2]_4 chr19:9929873-9929953 0.00014 43_[+2]_29 chr16:2955904-2955984 0.00014 41_[+2]_31 chr19:11616031-11616111 0.00014 16_[+2]_56 chr19:38997754-38997834 0.00014 [+2]_72 chr19:10981885-10981965 0.00014 50_[+2]_22 chr3:38066579-38066659 0.00014 45_[+2]_27 chr1:33647678-33647758 0.00014 63_[+2]_9 chr19:6678073-6678153 0.00014 42_[+2]_30 chr2:220417395-220417475 0.00014 51_[+2]_21 chr17:76136615-76136695 0.00014 2_[+2]_70 chr10:28592013-28592093 0.00014 25_[+2]_47 chr19:50143574-50143654 0.00014 1_[+2]_71 chr9:129987436-129987516 0.00014 31_[+2]_41 chr14:104181913-10418199 0.00028 8_[+2]_64 chr16:54963156-54963236 0.00028 4_[+2]_68 chrX:13752710-13752790 0.00028 60_[+2]_12 chr1:228247619-228247699 0.00028 34_[+2]_38 chr16:57769533-57769613 0.00028 61_[+2]_11 chr22:42896211-42896291 0.00028 7_[+2]_65 chr12:122277467-12227754 0.00028 37_[+2]_35 chr10:3215384-3215464 0.00028 33_[+2]_39 chr19:1455699-1455779 0.00028 69_[+2]_3 chr16:2186121-2186201 0.00028 1_[+2]_71 chr22:36784154-36784234 0.00028 48_[+2]_24 chr16:89768425-89768505 0.00028 31_[+2]_41 chr4:3076179-3076259 0.00028 31_[+2]_41 chrX:53711218-53711298 0.00028 60_[+2]_12 chr19:36266323-36266403 0.00028 24_[+2]_48 chr19:4556343-4556423 0.00028 63_[+2]_9 chr7:25902185-25902265 0.00028 63_[+2]_9 chr20:61425853-61425933 0.00028 26_[+2]_46 chr16:87594452-87594532 0.00028 2_[+2]_70 chr12:132166841-13216692 0.00028 43_[+2]_29 chr9:139237362-139237442 0.00035 1_[+2]_71 chr19:5904594-5904674 0.00035 58_[+2]_14 chr1:994949-995029 0.00035 61_[+2]_11 chr9:139916637-139916717 0.00035 25_[+2]_47 chr19:1123168-1123248 0.00035 22_[+2]_50 chr19:8657396-8657476 0.00035 67_[+2]_5 chr6:170475741-170475821 0.00035 8_[+2]_64 chr1:228362161-228362241 0.00035 9_[+2]_63 chr8:145596549-145596629 0.00042 64_[+2]_8 chr19:45394284-45394364 0.00042 35_[+2]_37 chr6:147981709-147981789 0.00042 1_[+2]_71 chr19:39436129-39436209 0.00042 55_[+2]_17 chr19:4310846-4310926 0.00046 57_[+2]_15 chr4:6597797-6597877 0.00053 29_[+2]_43 chr19:41076674-41076754 0.00053 40_[+2]_32 chr4:37688158-37688238 0.00053 65_[+2]_7 chrX:15756226-15756306 0.00053 6_[+2]_66 chr21:45848412-45848492 0.00053 64_[+2]_8 chr20:35064801-35064881 0.00057 23_[+2]_49 chr19:47931553-47931633 0.00057 5_[+2]_67 chr16:84048017-84048097 0.00057 54_[+2]_18 chr20:62184746-62184826 0.00057 46_[+2]_26 chr2:242823872-242823952 0.0006 23_[+2]_49 chr22:44588444-44588524 0.0006 54_[+2]_18 chr12:113659032-11365911 0.00069 13_[+2]_59 chr15:45571501-45571581 0.00069 46_[+2]_26 chr16:2479199-2479279 0.00069 59_[+2]_13 chr16:28947997-28948077 0.00069 46_[+2]_26 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGGGC MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GGCGGGGC width=8 seqs=79 chr19:17650634-17650714 ( 60) GGCGGGGC 1 chr19:36505247-36505327 ( 62) GGCGGGGC 1 chr19:48111962-48112042 ( 56) GGCGGGGC 1 chr19:10403091-10403171 ( 16) GGCGGGGC 1 chr11:65641087-65641167 ( 34) GGCGGGGC 1 chr11:67573297-67573377 ( 11) GGCGGGGC 1 chr19:18315031-18315111 ( 47) GGCGGGGC 1 chr19:1045387-1045467 ( 19) GGCGGGGC 1 chr20:60813321-60813401 ( 68) GGCGGGGC 1 chr19:1082572-1082652 ( 29) GGCGGGGC 1 chr19:9945797-9945877 ( 11) GGCGGGGC 1 chr19:47760470-47760550 ( 51) GGCGGGGC 1 chr7:138144729-138144809 ( 50) GGCGGGGC 1 chr19:17320597-17320677 ( 36) GGCGGGGC 1 chr19:40971802-40971882 ( 47) GGCGGGGC 1 chr5:114505661-114505741 ( 48) GGCGGGGC 1 chr14:100705088-10070516 ( 39) GGCGGGGC 1 chr22:19166343-19166423 ( 69) GGCGGGGC 1 chr19:9929873-9929953 ( 44) GGCGGGGC 1 chr16:2955904-2955984 ( 42) GGCGGGGC 1 chr19:11616031-11616111 ( 17) GGCGGGGC 1 chr19:38997754-38997834 ( 1) GGCGGGGC 1 chr19:10981885-10981965 ( 51) GGCGGGGC 1 chr3:38066579-38066659 ( 46) GGCGGGGC 1 chr1:33647678-33647758 ( 64) GGCGGGGC 1 chr19:6678073-6678153 ( 43) GGCGGGGC 1 chr2:220417395-220417475 ( 52) GGCGGGGC 1 chr17:76136615-76136695 ( 3) GGCGGGGC 1 chr10:28592013-28592093 ( 26) GGCGGGGC 1 chr19:50143574-50143654 ( 2) GGCGGGGC 1 chr9:129987436-129987516 ( 32) GGCGGGGC 1 chr14:104181913-10418199 ( 9) GGCGGAGC 1 chr16:54963156-54963236 ( 5) GGCGGAGC 1 chrX:13752710-13752790 ( 61) GGCGGAGC 1 chr1:228247619-228247699 ( 35) GGCGGAGC 1 chr16:57769533-57769613 ( 62) GGCGGAGC 1 chr22:42896211-42896291 ( 8) GGTGGGGC 1 chr12:122277467-12227754 ( 38) GGCGGAGC 1 chr10:3215384-3215464 ( 34) GGTGGGGC 1 chr19:1455699-1455779 ( 70) GGTGGGGC 1 chr16:2186121-2186201 ( 2) GGCGGAGC 1 chr22:36784154-36784234 ( 49) GGCGGAGC 1 chr16:89768425-89768505 ( 32) GGTGGGGC 1 chr4:3076179-3076259 ( 32) GGTGGGGC 1 chrX:53711218-53711298 ( 61) GGCGGAGC 1 chr19:36266323-36266403 ( 25) GGCGGAGC 1 chr19:4556343-4556423 ( 64) GGTGGGGC 1 chr7:25902185-25902265 ( 64) GGCGGAGC 1 chr20:61425853-61425933 ( 27) GGTGGGGC 1 chr16:87594452-87594532 ( 3) GGTGGGGC 1 chr12:132166841-13216692 ( 44) GGTGGGGC 1 chr9:139237362-139237442 ( 2) GGCGTGGC 1 chr19:5904594-5904674 ( 59) GGCGTGGC 1 chr1:994949-995029 ( 62) GGCGTGGC 1 chr9:139916637-139916717 ( 26) GGCGTGGC 1 chr19:1123168-1123248 ( 23) GGCGTGGC 1 chr19:8657396-8657476 ( 68) GGCGTGGC 1 chr6:170475741-170475821 ( 9) GGCGTGGC 1 chr1:228362161-228362241 ( 10) GGCGTGGC 1 chr8:145596549-145596629 ( 65) GGAGGGGC 1 chr19:45394284-45394364 ( 36) GGAGGGGC 1 chr6:147981709-147981789 ( 2) GGAGGGGC 1 chr19:39436129-39436209 ( 56) GGAGGGGC 1 chr19:4310846-4310926 ( 58) GGTGGAGC 1 chr4:6597797-6597877 ( 30) GGTGTGGC 1 chr19:41076674-41076754 ( 41) GGTGTGGC 1 chr4:37688158-37688238 ( 66) GGCGTAGC 1 chrX:15756226-15756306 ( 7) GGTGTGGC 1 chr21:45848412-45848492 ( 65) GGTGTGGC 1 chr20:35064801-35064881 ( 24) GGAGGAGC 1 chr19:47931553-47931633 ( 6) GGAGGAGC 1 chr16:84048017-84048097 ( 55) GGAGGAGC 1 chr20:62184746-62184826 ( 47) GGAGGAGC 1 chr2:242823872-242823952 ( 24) GGAGTGGC 1 chr22:44588444-44588524 ( 55) GGAGTGGC 1 chr12:113659032-11365911 ( 14) GGCGGGGA 1 chr15:45571501-45571581 ( 47) GGCGGGGA 1 chr16:2479199-2479279 ( 60) GGCGGGGA 1 chr16:28947997-28948077 ( 47) GGCGGGGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGGGC MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.78077 E= 1.1e-018 -1295 -1295 161 -1295 -1295 -1295 161 -1295 -45 108 -1295 6 -1295 -1295 161 -1295 -1295 -1295 131 16 32 -1295 126 -1295 -1295 -1295 161 -1295 -177 153 -1295 -1295 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGGGC MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 79 E= 1.1e-018 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.126582 0.696203 0.000000 0.177215 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.810127 0.189873 0.215190 0.000000 0.784810 0.000000 0.000000 0.000000 1.000000 0.000000 0.050633 0.949367 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGGGC MEME-2 regular expression -------------------------------------------------------------------------------- GGCGG[GA]GC -------------------------------------------------------------------------------- Time 8.52 secs. ******************************************************************************** ******************************************************************************** MOTIF CYCCGCCC MEME-3 width = 8 sites = 117 llr = 757 E-value = 1.3e-013 ******************************************************************************** -------------------------------------------------------------------------------- Motif CYCCGCCC MEME-3 Description -------------------------------------------------------------------------------- Simplified A 112:1::: pos.-specific C 858a:aa9 probability G ::::7::: matrix T 14::2::1 bits 2.6 2.3 2.0 1.8 Relative 1.5 * ** Entropy 1.3 * ** (9.3 bits) 1.0 ** *** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel CCCCGCCC consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CYCCGCCC MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr15:45571501-45571581 35 7.20e-05 CGCTCTTGGG CTCCGCCC TGGAGGCGGG chr1:2064713-2064793 55 7.20e-05 CGTCCCTCGG CTCCGCCC CCAGTTGCTC chr19:48996279-48996359 48 7.20e-05 CCGCCCTAGG CTCCGCCC CCATTCCAGC chr8:124428714-124428794 46 7.20e-05 TCGTCCCGGG CTCCGCCC ACCGGGAGTT chr15:78730396-78730476 49 7.20e-05 TTCTGGTTAG CTCCGCCC CTTCCCTTTC chr17:40075316-40075396 40 7.20e-05 GCTGGCTTGG CTCCGCCC CACGAGGGCG chr9:130159195-130159275 48 7.20e-05 CCTTGGACCG CTCCGCCC TAGGGGCGGT chr10:135186890-13518697 13 7.20e-05 TCAGGGCTCG CTCCGCCC ACAGGCCAGC chr19:8115582-8115662 2 7.20e-05 G CTCCGCCC ACTGTCTTAA chr11:13484820-13484900 59 7.20e-05 GAACGGTGCT CTCCGCCC AGGGGTGGGC chr1:160068396-160068476 21 7.20e-05 AATCCCCTCC CTCCGCCC CTCCCGCTGC chr19:7985165-7985245 36 7.20e-05 GCCCCCGTAG CTCCGCCC ATCGGAGAAG chr16:2186121-2186201 71 7.20e-05 ATTTTTCACG CTCCGCCC CG chr9:130533677-130533757 68 7.20e-05 TGCGGTCTCG CTCCGCCC CCTCC chr1:31191051-31191131 47 7.20e-05 TTAGCGCTGG CTCCGCCC CTAGCCTTGG chr1:41826839-41826919 14 7.20e-05 AGTGTTAGGG CTCCGCCC CCTAGCCCCC chr19:6767595-6767675 17 7.20e-05 CAGGCCCTTG CTCCGCCC CCTTAAAACC chr16:28947997-28948077 35 7.20e-05 GAGCTCGGAA CTCCGCCC CCGGGGCGGG chr9:140044948-140045028 3 7.20e-05 GT CTCCGCCC AGATAAAAGC chr1:33647678-33647758 37 7.20e-05 ACCCAAGCAA CTCCGCCC CCGCAGCGGG chr3:128840883-128840963 23 7.20e-05 cccgccccga ctccgccc tcagcccgaa chr19:14629428-14629508 27 2.12e-04 TCGGAGGAGG CCCCGCCC ACCTTTCGGG chr9:140353824-140353904 73 2.12e-04 GGACATGTGG CCCCGCCC chr19:16739129-16739209 63 2.12e-04 GCCCGTGACG CCCCGCCC AGCCGCCCGG chr19:17443594-17443674 59 2.12e-04 TGGATCTGGG CCCCGCCC TCCTGCTCCT chr5:176853453-176853533 10 2.12e-04 GGGGCTGAA CCCCGCCC TCAGACCAAC chr15:69452838-69452918 39 2.12e-04 CCCGCCGTGG CCCCGCCC CTTGCCGTGG chr2:97202327-97202407 36 2.12e-04 CAAGGGCGGT CCCCGCCC CCCGCCTTCT chr19:47950875-47950955 23 2.12e-04 GGGTCACAGG CCCCGCCC ACGTTGCGGG chr16:1993353-1993433 49 2.12e-04 TTCCCCAAGG CCCCGCCC CCCGGTGCCA chr1:1850856-1850936 36 2.12e-04 GCAGGGTAAA CCCCGCCC TCCGGGCACC chr19:36266323-36266403 64 2.12e-04 TCCCGCTgcc ccccgccc ccgtggggc chr1:2126416-2126496 2 2.12e-04 G CCCCGCCC GTGTCCCCTT chr19:1063082-1063162 58 2.12e-04 ACCAGTGTGG CCCCGCCC CATACTCATG chr20:61425853-61425933 16 2.12e-04 ccggccccgg ccccgccc cgcGGTGGGG chr21:37528801-37528881 61 2.12e-04 CCAGCCGAGG CCCCGCCC CTGTAGGGAC chr6:37137819-37137899 53 2.12e-04 cccgccccgt ccccgccc gccgcgccct chr19:4310846-4310926 47 2.12e-04 CCTCATGAGG CCCCGCCC TGGGGTGGAG chr21:46825455-46825535 19 2.12e-04 GCTCCCTCAC CCCCGCCC CGGCCGCTCT chr8:143858985-143859065 7 2.12e-04 CGCAGG CCCCGCCC CGGACCCGCC chr11:72525255-72525335 50 2.49e-04 CCGGAGGCGG CTCCTCCC GGAGGCAGAT chr12:50561239-50561319 25 2.49e-04 CCGCCCATCT CTCCTCCC GGCCCACTTC chr2:136743187-136743267 65 2.49e-04 CGCGCAGGGT CTCCTCCC ACTCTTGC chr17:79093576-79093656 61 2.49e-04 GGACCAGGTG CTCCTCCC ATGATGTCAC chr17:7760868-7760948 22 2.49e-04 GAGATCCCCT CTCCTCCC CCTCCTAGTC chr19:7670529-7670609 73 2.49e-04 CGAGGTCTGG CTCCTCCC chr21:45848412-45848492 53 2.49e-04 TGAGGTGTGA CTCCTCCC CTTAGGTGTG chr15:72410535-72410615 70 4.34e-04 GCCCCCTTTC CTACGCCC CAG chr19:41304803-41304883 70 4.34e-04 CACTGCGTTC CCCCTCCC GCG chr14:29299352-29299432 67 4.34e-04 tcgctgcaag ctccgcct cccggg chr19:50249576-50249656 13 4.34e-04 GTCCCCGAGG CTCCACCC ATGTCACCGC chr19:18315031-18315111 11 4.34e-04 CGGGGGCCGA CTCCGCCT CTCGTCCGCC chr4:4674905-4674985 37 4.34e-04 CCACGCCTAC CCCCTCCC TGACCACTCC chr7:130756967-130757047 35 4.34e-04 tccgggaaat ctccaccc ctttcctgga chr16:84047811-84047891 27 4.34e-04 CCTCTGAAAG CTCCACCC TAAGCCCGAG chr19:1490880-1490960 8 4.72e-04 CCCCCGG TTCCGCCC CCCCACGCCT chr9:130981128-130981208 25 4.72e-04 CCTGCCGTGA TTCCGCCC ACTTCCGGCC chr1:175162067-175162147 66 4.72e-04 TGGCTCGCCG TTCCGCCC GCTCCAG chr20:35064801-35064881 48 7.64e-04 TTAAAATAAG CCCCGCCT GCGTGGGAGC chr8:103251460-103251540 28 7.64e-04 TCTCGGCAAG CCCCGCCT GCCTTGGGGC chr19:19729572-19729652 73 7.64e-04 CGGCGCCACG CACCGCCC chr1:3817918-3817998 9 7.64e-04 TCCAATGG CCACGCCC CTAGCAGGCC chr6:52284958-52285038 8 7.64e-04 GACACAA CCACGCCC ACTAGCCGCG chr19:4124139-4124219 56 7.64e-04 CCGCGATGGA CCCCACCC CCAGCCGCCG chr7:20837955-20838035 50 7.64e-04 GACGGCGGct ccccaccc ctgcactcag chr19:51870879-51870959 10 7.64e-04 GCACCCAGG CCACGCCC CTTCAGACCC chr19:47164580-47164660 70 7.64e-04 GGGGCCCTGG CCACGCCC CCC chr1:207226305-207226385 61 7.64e-04 TTTTTATTAA CACCGCCC CCAGCCCTAT chr20:60813321-60813401 15 7.64e-04 GGCGGCATAA CCCCGCCT CTCTCCTGCT chr19:18633081-18633161 53 7.64e-04 GCACTTATGG CCCCGCCT CTTCAGGCCC chr19:10946382-10946462 20 7.64e-04 AGCACTATCG CCACGCCC ACCAGCCAGA chr11:67764410-67764490 29 7.64e-04 CAGCTCAAGG CCCCGCCT CTCAGCACAA chr7:72847974-72848054 5 7.64e-04 CCGG CCCCACCC CGTGCTCCGC chr19:40971802-40971882 14 7.64e-04 CACCGTCCAG CACCGCCC TCTCTGCGCG chr6:167040932-167041012 10 7.64e-04 CCGGGAGAG CCCCGCCT CTGCCGATAC chr15:44580889-44580969 27 7.64e-04 CGGTTTTTTT CCCCGCCT CCCAACCGTG chr1:21934437-21934517 58 7.64e-04 TTCGCCCCAG CCACGCCC CCTCTCAGAC chr7:44788255-44788335 49 7.64e-04 GCGGCCCTGG CCCCACCC TGCCGCTTTG chr19:3574021-3574101 73 7.64e-04 CAGCAGAAAA CCACGCCC chr10:28592013-28592093 36 7.64e-04 GGCGGGGCTG CACCGCCC GCGGGTAAGA chrX:1571976-1572056 8 7.64e-04 CACCAGG CCACGCCC ATGTCACGCC chr16:22202005-22202085 69 7.64e-04 CATGTTTTGA CCACGCCC TTGA chr12:113659032-11365911 54 8.36e-04 GGATTCTTCG TCCCGCCC CTTCTTAAGG chr10:127408093-12740817 65 8.36e-04 GCACTACAAT TCCCGCCC TGGCCGCG chr19:4328494-4328574 6 8.74e-04 cccca atccgccc agctcagctc chr19:4556343-4556423 33 8.74e-04 GAGGAGAAGG ATCCGCCC TGGGTGTGGT chr18:75705700-75705780 62 1.00e-03 cacgggaaag acccgccc ccataacgca chr5:125849880-125849960 47 1.00e-03 gaattgagag ttcctccc cttgtagacc chr5:34929452-34929532 38 1.00e-03 AAGGCCTACC TTCCTCCC ACGCGGCCCG chrX:109244182-109244262 43 1.00e-03 gaactgaggg ttcctccc cctttcagac chr7:157100650-157100730 72 1.00e-03 gaactgaggg ttcctccc c chr2:17699717-17699797 53 1.00e-03 CACGCCCCTG ACCCGCCC CTCAAGACCT chr21:47673702-47673782 70 1.18e-03 aagtgtgcag cacctccc cct chr2:232759818-232759898 72 1.18e-03 aagtgggtgg cacctccc t chr7:138144729-138144809 66 1.18e-03 GCTGGGCAAG CACCTCCC ACTTCCC chr12:49351290-49351370 14 1.18e-03 GGATACTTCC CACCTCCC CGATCGCGCG chr7:155610381-155610461 9 1.18e-03 TGGCTCAG CCACTCCC ATTGGAGGAG chr4:103749178-103749258 27 1.27e-03 CCTGACGGGG TTCCGCCT CCAAAATGCA chr19:11457106-11457186 73 1.52e-03 AAAATGCCGG CCACACCC chr17:79980926-79981006 38 1.52e-03 CCTCCCGGGG CACCACCC TCACGACCCT chr19:889065-889145 67 1.52e-03 CCAACCCTGG CCACGCCT ACTCTT chr12:57940967-57941047 69 1.52e-03 AGCCCTGCTG CCACACCC CTGG chr8:144302021-144302101 34 1.52e-03 CAAACCCTAA CCACGCCT CCCTCCTGAC chr16:84048017-84048097 16 1.52e-03 AGCTGTGTGG CCACACCC CTCACCTCTG chr19:10981885-10981965 6 1.52e-03 CCCCG CACCGCCT CACTCGAAAG chr19:18747472-18747552 53 1.52e-03 TTCGCCCCGT CCCCACCT ATCCACAGAC chr6:147981709-147981789 44 1.67e-03 agggcggatc tcccaccc tcgctgttct chr10:104677948-10467802 7 1.67e-03 ACACGG TCACGCCC CCATTCCAGC chr4:37688158-37688238 11 1.67e-03 CTCAGCCTGA TCCCGCCT CTCCCTGCCA chr10:134093648-13409372 14 1.67e-03 CACTCTGTGA TCACGCCC CTGCACTCCG chr16:20956640-20956720 69 1.77e-03 ctcatgaata atccaccc cttg chr19:3285251-3285331 61 1.77e-03 CCTGCCCCTT ACCCTCCC TCCTGCAGCT chr10:48354863-48354943 52 1.77e-03 GGCCAGCGGC ACCCTCCC CTGCCGGGGC chr11:5526911-5526991 54 1.95e-03 catgggaaag acccaccc ccatgattca chr22:35627075-35627155 59 1.95e-03 gcatgggggg aaccgccc tcatgatcca chr17:53046026-53046106 2 1.95e-03 C ACCCGCCT CTCAGGGACG chr19:55038334-55038414 66 2.11e-03 AGCATGAGAT TCCCTCCT ATCGCGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CYCCGCCC MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr15:45571501-45571581 7.2e-05 34_[+3]_38 chr1:2064713-2064793 7.2e-05 54_[+3]_18 chr19:48996279-48996359 7.2e-05 47_[+3]_25 chr8:124428714-124428794 7.2e-05 45_[+3]_27 chr15:78730396-78730476 7.2e-05 48_[+3]_24 chr17:40075316-40075396 7.2e-05 39_[+3]_33 chr9:130159195-130159275 7.2e-05 47_[+3]_25 chr10:135186890-13518697 7.2e-05 12_[+3]_60 chr19:8115582-8115662 7.2e-05 1_[+3]_71 chr11:13484820-13484900 7.2e-05 58_[+3]_14 chr1:160068396-160068476 7.2e-05 20_[+3]_52 chr19:7985165-7985245 7.2e-05 35_[+3]_37 chr16:2186121-2186201 7.2e-05 70_[+3]_2 chr9:130533677-130533757 7.2e-05 67_[+3]_5 chr1:31191051-31191131 7.2e-05 46_[+3]_26 chr1:41826839-41826919 7.2e-05 13_[+3]_59 chr19:6767595-6767675 7.2e-05 16_[+3]_56 chr16:28947997-28948077 7.2e-05 34_[+3]_38 chr9:140044948-140045028 7.2e-05 2_[+3]_70 chr1:33647678-33647758 7.2e-05 36_[+3]_36 chr3:128840883-128840963 7.2e-05 22_[+3]_50 chr19:14629428-14629508 0.00021 26_[+3]_46 chr9:140353824-140353904 0.00021 72_[+3] chr19:16739129-16739209 0.00021 62_[+3]_10 chr19:17443594-17443674 0.00021 58_[+3]_14 chr5:176853453-176853533 0.00021 9_[+3]_63 chr15:69452838-69452918 0.00021 38_[+3]_34 chr2:97202327-97202407 0.00021 35_[+3]_37 chr19:47950875-47950955 0.00021 22_[+3]_50 chr16:1993353-1993433 0.00021 48_[+3]_24 chr1:1850856-1850936 0.00021 35_[+3]_37 chr19:36266323-36266403 0.00021 63_[+3]_9 chr1:2126416-2126496 0.00021 1_[+3]_71 chr19:1063082-1063162 0.00021 57_[+3]_15 chr20:61425853-61425933 0.00021 15_[+3]_57 chr21:37528801-37528881 0.00021 60_[+3]_12 chr6:37137819-37137899 0.00021 52_[+3]_20 chr19:4310846-4310926 0.00021 46_[+3]_26 chr21:46825455-46825535 0.00021 18_[+3]_54 chr8:143858985-143859065 0.00021 6_[+3]_66 chr11:72525255-72525335 0.00025 49_[+3]_23 chr12:50561239-50561319 0.00025 24_[+3]_48 chr2:136743187-136743267 0.00025 64_[+3]_8 chr17:79093576-79093656 0.00025 60_[+3]_12 chr17:7760868-7760948 0.00025 21_[+3]_51 chr19:7670529-7670609 0.00025 72_[+3] chr21:45848412-45848492 0.00025 52_[+3]_20 chr15:72410535-72410615 0.00043 69_[+3]_3 chr19:41304803-41304883 0.00043 69_[+3]_3 chr14:29299352-29299432 0.00043 66_[+3]_6 chr19:50249576-50249656 0.00043 12_[+3]_60 chr19:18315031-18315111 0.00043 10_[+3]_62 chr4:4674905-4674985 0.00043 36_[+3]_36 chr7:130756967-130757047 0.00043 34_[+3]_38 chr16:84047811-84047891 0.00043 26_[+3]_46 chr19:1490880-1490960 0.00047 7_[+3]_65 chr9:130981128-130981208 0.00047 24_[+3]_48 chr1:175162067-175162147 0.00047 65_[+3]_7 chr20:35064801-35064881 0.00076 47_[+3]_25 chr8:103251460-103251540 0.00076 27_[+3]_45 chr19:19729572-19729652 0.00076 72_[+3] chr1:3817918-3817998 0.00076 8_[+3]_64 chr6:52284958-52285038 0.00076 7_[+3]_65 chr19:4124139-4124219 0.00076 55_[+3]_17 chr7:20837955-20838035 0.00076 49_[+3]_23 chr19:51870879-51870959 0.00076 9_[+3]_63 chr19:47164580-47164660 0.00076 69_[+3]_3 chr1:207226305-207226385 0.00076 60_[+3]_12 chr20:60813321-60813401 0.00076 14_[+3]_58 chr19:18633081-18633161 0.00076 52_[+3]_20 chr19:10946382-10946462 0.00076 19_[+3]_53 chr11:67764410-67764490 0.00076 28_[+3]_44 chr7:72847974-72848054 0.00076 4_[+3]_68 chr19:40971802-40971882 0.00076 13_[+3]_59 chr6:167040932-167041012 0.00076 9_[+3]_63 chr15:44580889-44580969 0.00076 26_[+3]_46 chr1:21934437-21934517 0.00076 57_[+3]_15 chr7:44788255-44788335 0.00076 48_[+3]_24 chr19:3574021-3574101 0.00076 72_[+3] chr10:28592013-28592093 0.00076 35_[+3]_37 chrX:1571976-1572056 0.00076 7_[+3]_65 chr16:22202005-22202085 0.00076 68_[+3]_4 chr12:113659032-11365911 0.00084 53_[+3]_19 chr10:127408093-12740817 0.00084 64_[+3]_8 chr19:4328494-4328574 0.00087 5_[+3]_67 chr19:4556343-4556423 0.00087 32_[+3]_40 chr18:75705700-75705780 0.001 61_[+3]_11 chr5:125849880-125849960 0.001 46_[+3]_26 chr5:34929452-34929532 0.001 37_[+3]_35 chrX:109244182-109244262 0.001 42_[+3]_30 chr7:157100650-157100730 0.001 71_[+3]_1 chr2:17699717-17699797 0.001 52_[+3]_20 chr21:47673702-47673782 0.0012 69_[+3]_3 chr2:232759818-232759898 0.0012 71_[+3]_1 chr7:138144729-138144809 0.0012 65_[+3]_7 chr12:49351290-49351370 0.0012 13_[+3]_59 chr7:155610381-155610461 0.0012 8_[+3]_64 chr4:103749178-103749258 0.0013 26_[+3]_46 chr19:11457106-11457186 0.0015 72_[+3] chr17:79980926-79981006 0.0015 37_[+3]_35 chr19:889065-889145 0.0015 66_[+3]_6 chr12:57940967-57941047 0.0015 68_[+3]_4 chr8:144302021-144302101 0.0015 33_[+3]_39 chr16:84048017-84048097 0.0015 15_[+3]_57 chr19:10981885-10981965 0.0015 5_[+3]_67 chr19:18747472-18747552 0.0015 52_[+3]_20 chr6:147981709-147981789 0.0017 43_[+3]_29 chr10:104677948-10467802 0.0017 6_[+3]_66 chr4:37688158-37688238 0.0017 10_[+3]_62 chr10:134093648-13409372 0.0017 13_[+3]_59 chr16:20956640-20956720 0.0018 68_[+3]_4 chr19:3285251-3285331 0.0018 60_[+3]_12 chr10:48354863-48354943 0.0018 51_[+3]_21 chr11:5526911-5526991 0.002 53_[+3]_19 chr22:35627075-35627155 0.002 58_[+3]_14 chr17:53046026-53046106 0.002 1_[+3]_71 chr19:55038334-55038414 0.0021 65_[+3]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CYCCGCCC MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CYCCGCCC width=8 seqs=117 chr15:45571501-45571581 ( 35) CTCCGCCC 1 chr1:2064713-2064793 ( 55) CTCCGCCC 1 chr19:48996279-48996359 ( 48) CTCCGCCC 1 chr8:124428714-124428794 ( 46) CTCCGCCC 1 chr15:78730396-78730476 ( 49) CTCCGCCC 1 chr17:40075316-40075396 ( 40) CTCCGCCC 1 chr9:130159195-130159275 ( 48) CTCCGCCC 1 chr10:135186890-13518697 ( 13) CTCCGCCC 1 chr19:8115582-8115662 ( 2) CTCCGCCC 1 chr11:13484820-13484900 ( 59) CTCCGCCC 1 chr1:160068396-160068476 ( 21) CTCCGCCC 1 chr19:7985165-7985245 ( 36) CTCCGCCC 1 chr16:2186121-2186201 ( 71) CTCCGCCC 1 chr9:130533677-130533757 ( 68) CTCCGCCC 1 chr1:31191051-31191131 ( 47) CTCCGCCC 1 chr1:41826839-41826919 ( 14) CTCCGCCC 1 chr19:6767595-6767675 ( 17) CTCCGCCC 1 chr16:28947997-28948077 ( 35) CTCCGCCC 1 chr9:140044948-140045028 ( 3) CTCCGCCC 1 chr1:33647678-33647758 ( 37) CTCCGCCC 1 chr3:128840883-128840963 ( 23) CTCCGCCC 1 chr19:14629428-14629508 ( 27) CCCCGCCC 1 chr9:140353824-140353904 ( 73) CCCCGCCC 1 chr19:16739129-16739209 ( 63) CCCCGCCC 1 chr19:17443594-17443674 ( 59) CCCCGCCC 1 chr5:176853453-176853533 ( 10) CCCCGCCC 1 chr15:69452838-69452918 ( 39) CCCCGCCC 1 chr2:97202327-97202407 ( 36) CCCCGCCC 1 chr19:47950875-47950955 ( 23) CCCCGCCC 1 chr16:1993353-1993433 ( 49) CCCCGCCC 1 chr1:1850856-1850936 ( 36) CCCCGCCC 1 chr19:36266323-36266403 ( 64) CCCCGCCC 1 chr1:2126416-2126496 ( 2) CCCCGCCC 1 chr19:1063082-1063162 ( 58) CCCCGCCC 1 chr20:61425853-61425933 ( 16) CCCCGCCC 1 chr21:37528801-37528881 ( 61) CCCCGCCC 1 chr6:37137819-37137899 ( 53) CCCCGCCC 1 chr19:4310846-4310926 ( 47) CCCCGCCC 1 chr21:46825455-46825535 ( 19) CCCCGCCC 1 chr8:143858985-143859065 ( 7) CCCCGCCC 1 chr11:72525255-72525335 ( 50) CTCCTCCC 1 chr12:50561239-50561319 ( 25) CTCCTCCC 1 chr2:136743187-136743267 ( 65) CTCCTCCC 1 chr17:79093576-79093656 ( 61) CTCCTCCC 1 chr17:7760868-7760948 ( 22) CTCCTCCC 1 chr19:7670529-7670609 ( 73) CTCCTCCC 1 chr21:45848412-45848492 ( 53) CTCCTCCC 1 chr15:72410535-72410615 ( 70) CTACGCCC 1 chr19:41304803-41304883 ( 70) CCCCTCCC 1 chr14:29299352-29299432 ( 67) CTCCGCCT 1 chr19:50249576-50249656 ( 13) CTCCACCC 1 chr19:18315031-18315111 ( 11) CTCCGCCT 1 chr4:4674905-4674985 ( 37) CCCCTCCC 1 chr7:130756967-130757047 ( 35) CTCCACCC 1 chr16:84047811-84047891 ( 27) CTCCACCC 1 chr19:1490880-1490960 ( 8) TTCCGCCC 1 chr9:130981128-130981208 ( 25) TTCCGCCC 1 chr1:175162067-175162147 ( 66) TTCCGCCC 1 chr20:35064801-35064881 ( 48) CCCCGCCT 1 chr8:103251460-103251540 ( 28) CCCCGCCT 1 chr19:19729572-19729652 ( 73) CACCGCCC 1 chr1:3817918-3817998 ( 9) CCACGCCC 1 chr6:52284958-52285038 ( 8) CCACGCCC 1 chr19:4124139-4124219 ( 56) CCCCACCC 1 chr7:20837955-20838035 ( 50) CCCCACCC 1 chr19:51870879-51870959 ( 10) CCACGCCC 1 chr19:47164580-47164660 ( 70) CCACGCCC 1 chr1:207226305-207226385 ( 61) CACCGCCC 1 chr20:60813321-60813401 ( 15) CCCCGCCT 1 chr19:18633081-18633161 ( 53) CCCCGCCT 1 chr19:10946382-10946462 ( 20) CCACGCCC 1 chr11:67764410-67764490 ( 29) CCCCGCCT 1 chr7:72847974-72848054 ( 5) CCCCACCC 1 chr19:40971802-40971882 ( 14) CACCGCCC 1 chr6:167040932-167041012 ( 10) CCCCGCCT 1 chr15:44580889-44580969 ( 27) CCCCGCCT 1 chr1:21934437-21934517 ( 58) CCACGCCC 1 chr7:44788255-44788335 ( 49) CCCCACCC 1 chr19:3574021-3574101 ( 73) CCACGCCC 1 chr10:28592013-28592093 ( 36) CACCGCCC 1 chrX:1571976-1572056 ( 8) CCACGCCC 1 chr16:22202005-22202085 ( 69) CCACGCCC 1 chr12:113659032-11365911 ( 54) TCCCGCCC 1 chr10:127408093-12740817 ( 65) TCCCGCCC 1 chr19:4328494-4328574 ( 6) ATCCGCCC 1 chr19:4556343-4556423 ( 33) ATCCGCCC 1 chr18:75705700-75705780 ( 62) ACCCGCCC 1 chr5:125849880-125849960 ( 47) TTCCTCCC 1 chr5:34929452-34929532 ( 38) TTCCTCCC 1 chrX:109244182-109244262 ( 43) TTCCTCCC 1 chr7:157100650-157100730 ( 72) TTCCTCCC 1 chr2:17699717-17699797 ( 53) ACCCGCCC 1 chr21:47673702-47673782 ( 70) CACCTCCC 1 chr2:232759818-232759898 ( 72) CACCTCCC 1 chr7:138144729-138144809 ( 66) CACCTCCC 1 chr12:49351290-49351370 ( 14) CACCTCCC 1 chr7:155610381-155610461 ( 9) CCACTCCC 1 chr4:103749178-103749258 ( 27) TTCCGCCT 1 chr19:11457106-11457186 ( 73) CCACACCC 1 chr17:79980926-79981006 ( 38) CACCACCC 1 chr19:889065-889145 ( 67) CCACGCCT 1 chr12:57940967-57941047 ( 69) CCACACCC 1 chr8:144302021-144302101 ( 34) CCACGCCT 1 chr16:84048017-84048097 ( 16) CCACACCC 1 chr19:10981885-10981965 ( 6) CACCGCCT 1 chr19:18747472-18747552 ( 53) CCCCACCT 1 chr6:147981709-147981789 ( 44) TCCCACCC 1 chr10:104677948-10467802 ( 7) TCACGCCC 1 chr4:37688158-37688238 ( 11) TCCCGCCT 1 chr10:134093648-13409372 ( 14) TCACGCCC 1 chr16:20956640-20956720 ( 69) ATCCACCC 1 chr19:3285251-3285331 ( 61) ACCCTCCC 1 chr10:48354863-48354943 ( 52) ACCCTCCC 1 chr11:5526911-5526991 ( 54) ACCCACCC 1 chr22:35627075-35627155 ( 59) AACCGCCC 1 chr17:53046026-53046106 ( 2) ACCCGCCT 1 chr19:55038334-55038414 ( 66) TCCCTCCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CYCCGCCC MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 7.9286 E= 1.3e-013 -101 125 -1351 -41 -88 66 -1351 118 -17 136 -1351 -1351 -1351 160 -1351 -1351 -43 -1351 108 8 -1351 160 -1351 -1351 -1351 160 -1351 -1351 -1351 137 -1351 -23 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CYCCGCCC MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 117 E= 1.3e-013 0.085470 0.786325 0.000000 0.128205 0.094017 0.521368 0.000000 0.384615 0.153846 0.846154 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.128205 0.000000 0.692308 0.179487 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.854701 0.000000 0.145299 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CYCCGCCC MEME-3 regular expression -------------------------------------------------------------------------------- C[CT]CCGCCC -------------------------------------------------------------------------------- Time 12.04 secs. ******************************************************************************** ******************************************************************************** MOTIF TCRCGAGA MEME-4 width = 8 sites = 30 llr = 275 E-value = 2.7e-008 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCRCGAGA MEME-4 Description -------------------------------------------------------------------------------- Simplified A ::41:a:a pos.-specific C 2a:8:::: probability G ::6:a:9: matrix T 8::1::1: bits 2.6 * * 2.3 * * 2.0 * * 1.8 * * * Relative 1.5 ** ** * Entropy 1.3 ** **** (13.2 bits) 1.0 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel TCGCGAGA consensus A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCRCGAGA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr18:75705700-75705780 40 1.03e-05 ccattcacta tcacgaga acagcacggg chr11:5526911-5526991 32 1.03e-05 ccattcactg tcacgaga acagcatggg chr12:131153973-13115405 71 1.03e-05 gaggaagttc tcacgaga tc chr7:139677139-139677219 51 1.03e-05 ttactcacta tcacgaga acagcacggg chr22:35627075-35627155 38 1.03e-05 tcactcacta tcacgaga acggcatggg chr11:1285835-1285915 43 1.03e-05 tcactcacta tcacgaga acagcatggg chr14:30766263-30766343 45 1.03e-05 tcacgcacta tcacgaga acagcagagg chr11:119773602-11977368 54 1.03e-05 ttattcacta tcacgaga atagcacgag chr21:47673702-47673782 45 2.99e-05 aaagtgagcc tcgcgaga cctggttaag chr19:3914382-3914462 24 2.99e-05 ttactcactg tcgcgaga atagcacagg chr2:136743187-136743267 9 2.99e-05 CAGAAAGA TCGCGAGA GCTGCGGCTA chr1:207224334-207224414 41 2.99e-05 GGGCCAAACA TCGCGAGA AGTTGCGGGT chr10:7830014-7830094 22 2.99e-05 GTTGCAACGG TCGCGAGA CTCCCCTCGC chr15:78730396-78730476 4 2.99e-05 CGC TCGCGAGA ACAGCGGCGA chr12:57940967-57941047 49 2.99e-05 AAAGCAAAAG TCGCGAGA ACAGCCCTGC chr10:135186890-13518697 51 2.99e-05 CAGGCGGCCC TCGCGAGA TCAGCCCGGG chr17:4167251-4167331 11 2.99e-05 GCCTGCAACC TCGCGAGA AGTGCGCGGC chr17:7760868-7760948 8 2.99e-05 TTTCCTT TCGCGAGA TCCCCTCTCC chrX:13752710-13752790 26 6.07e-05 GAAGCAGTTC TCGCGATA CCCTGGGATG chr2:232759818-232759898 21 6.07e-05 ggtgctgttc tcgtgaga gtgagtgcat chr1:232941064-232941144 64 6.07e-05 CTCCGGTTTC TCGTGAGA CCCCGGGGC chr3:49131521-49131601 2 6.07e-05 C TCGCGATA ATCGGGGCGT chr1:226033494-226033574 2 6.61e-05 G TCAAGAGA GTCCCTGAGT chrX:48660186-48660266 41 7.64e-05 GGGCGGGCAG TCGAGAGA CGAGGCCCAA chr16:87985036-87985116 61 9.64e-05 CCGACAAACA CCACGAGA ATTCCGCAGC chr11:134314449-13431452 5 9.64e-05 acta ccacgaga gcagcatggg chr10:127408093-12740817 12 1.34e-04 GAGTCAGATA CCGCGAGA AGTAGTCTCC chr6:52284958-52285038 48 1.34e-04 GGCCCACTTA CCGCGAGA ACGCGGAGTC chrX:153607311-153607391 67 1.34e-04 CTCGCTCCCA CCGCGAGA CCTTTT chr1:245508946-245509026 30 1.42e-04 gctgctgttc tcgtgata gtgagtgagt -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCRCGAGA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr18:75705700-75705780 1e-05 39_[+4]_33 chr11:5526911-5526991 1e-05 31_[+4]_41 chr12:131153973-13115405 1e-05 70_[+4]_2 chr7:139677139-139677219 1e-05 50_[+4]_22 chr22:35627075-35627155 1e-05 37_[+4]_35 chr11:1285835-1285915 1e-05 42_[+4]_30 chr14:30766263-30766343 1e-05 44_[+4]_28 chr11:119773602-11977368 1e-05 53_[+4]_19 chr21:47673702-47673782 3e-05 44_[+4]_28 chr19:3914382-3914462 3e-05 23_[+4]_49 chr2:136743187-136743267 3e-05 8_[+4]_64 chr1:207224334-207224414 3e-05 40_[+4]_32 chr10:7830014-7830094 3e-05 21_[+4]_51 chr15:78730396-78730476 3e-05 3_[+4]_69 chr12:57940967-57941047 3e-05 48_[+4]_24 chr10:135186890-13518697 3e-05 50_[+4]_22 chr17:4167251-4167331 3e-05 10_[+4]_62 chr17:7760868-7760948 3e-05 7_[+4]_65 chrX:13752710-13752790 6.1e-05 25_[+4]_47 chr2:232759818-232759898 6.1e-05 20_[+4]_52 chr1:232941064-232941144 6.1e-05 63_[+4]_9 chr3:49131521-49131601 6.1e-05 1_[+4]_71 chr1:226033494-226033574 6.6e-05 1_[+4]_71 chrX:48660186-48660266 7.6e-05 40_[+4]_32 chr16:87985036-87985116 9.6e-05 60_[+4]_12 chr11:134314449-13431452 9.6e-05 4_[+4]_68 chr10:127408093-12740817 0.00013 11_[+4]_61 chr6:52284958-52285038 0.00013 47_[+4]_25 chrX:153607311-153607391 0.00013 66_[+4]_6 chr1:245508946-245509026 0.00014 29_[+4]_43 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCRCGAGA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCRCGAGA width=8 seqs=30 chr18:75705700-75705780 ( 40) TCACGAGA 1 chr11:5526911-5526991 ( 32) TCACGAGA 1 chr12:131153973-13115405 ( 71) TCACGAGA 1 chr7:139677139-139677219 ( 51) TCACGAGA 1 chr22:35627075-35627155 ( 38) TCACGAGA 1 chr11:1285835-1285915 ( 43) TCACGAGA 1 chr14:30766263-30766343 ( 45) TCACGAGA 1 chr11:119773602-11977368 ( 54) TCACGAGA 1 chr21:47673702-47673782 ( 45) TCGCGAGA 1 chr19:3914382-3914462 ( 24) TCGCGAGA 1 chr2:136743187-136743267 ( 9) TCGCGAGA 1 chr1:207224334-207224414 ( 41) TCGCGAGA 1 chr10:7830014-7830094 ( 22) TCGCGAGA 1 chr15:78730396-78730476 ( 4) TCGCGAGA 1 chr12:57940967-57941047 ( 49) TCGCGAGA 1 chr10:135186890-13518697 ( 51) TCGCGAGA 1 chr17:4167251-4167331 ( 11) TCGCGAGA 1 chr17:7760868-7760948 ( 8) TCGCGAGA 1 chrX:13752710-13752790 ( 26) TCGCGATA 1 chr2:232759818-232759898 ( 21) TCGTGAGA 1 chr1:232941064-232941144 ( 64) TCGTGAGA 1 chr3:49131521-49131601 ( 2) TCGCGATA 1 chr1:226033494-226033574 ( 2) TCAAGAGA 1 chrX:48660186-48660266 ( 41) TCGAGAGA 1 chr16:87985036-87985116 ( 61) CCACGAGA 1 chr11:134314449-13431452 ( 5) CCACGAGA 1 chr10:127408093-12740817 ( 12) CCGCGAGA 1 chr6:52284958-52285038 ( 48) CCGCGAGA 1 chrX:153607311-153607391 ( 67) CCGCGAGA 1 chr1:245508946-245509026 ( 30) TCGTGATA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCRCGAGA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.92146 E= 2.7e-008 -1155 -98 -1155 229 -1155 160 -1155 -1155 109 -1155 95 -1155 -137 134 -1155 -77 -1155 -1155 161 -1155 253 -1155 -1155 -1155 -1155 -1155 146 -77 253 -1155 -1155 -1155 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCRCGAGA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 30 E= 2.7e-008 0.000000 0.166667 0.000000 0.833333 0.000000 1.000000 0.000000 0.000000 0.366667 0.000000 0.633333 0.000000 0.066667 0.833333 0.000000 0.100000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.900000 0.100000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCRCGAGA MEME-4 regular expression -------------------------------------------------------------------------------- TC[GA]CGAGA -------------------------------------------------------------------------------- Time 15.30 secs. ******************************************************************************** ******************************************************************************** MOTIF KGGGCGKG MEME-5 width = 8 sites = 48 llr = 372 E-value = 3.7e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif KGGGCGKG MEME-5 Description -------------------------------------------------------------------------------- Simplified A 1::::::: pos.-specific C ::::a::: probability G 5aaa:a4a matrix T 4:::::6: bits 2.6 2.3 2.0 1.8 Relative 1.5 *** * Entropy 1.3 ******* (11.2 bits) 1.0 ******* 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel GGGGCGTG consensus T G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGKG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr9:139237362-139237442 20 3.62e-05 CTTGCTGTTG TGGGCGTG GTCCATGGGG chr4:6597797-6597877 65 3.62e-05 GGTGTCCAGG TGGGCGTG GTATCCAG chr7:72847974-72848054 71 3.62e-05 GGCGTGTCCC TGGGCGTG TC chr9:139916637-139916717 64 3.62e-05 TCAGACGGTC TGGGCGTG ACTCAGGCT chr19:6678073-6678153 30 3.62e-05 GACAATGGTG TGGGCGTG GCATGGGCGG chrX:15756226-15756306 48 3.62e-05 ACAGTTTGGT TGGGCGTG ACCGGGGCAA chr19:49866861-49866941 58 3.62e-05 TCAACTGACG TGGGCGTG GTCTGACTGT chr1:228362161-228362241 24 3.62e-05 tggctcgctg tgggcgtg gctcgctgtg chr1:228361809-228361889 72 3.62e-05 tggctcgctg tgggcgtg g chr12:113659032-11365911 37 1.06e-04 GGAGGAGTAA GGGGCGTG GATTCTTCGT chr19:17650634-17650714 42 1.06e-04 ATGTAAAATG GGGGCGTG GTCAGAGAGG chr11:65641087-65641167 8 1.06e-04 CGAAGTG GGGGCGTG TCCTTGGGGC chr7:72298865-72298945 57 1.06e-04 GAGGGGAAAG GGGGCGTG TCCAGAAATA chr19:1045387-1045467 39 1.06e-04 AGGTGCATGA GGGGCGTG GCCATGGGCC chr12:122277467-12227754 21 1.06e-04 GCCCCGCCGA GGGGCGTG GTCAGTGTGG chr19:47760470-47760550 16 1.06e-04 AGGGAGTCAG GGGGCGTG TCCAGGAGGT chr19:47931553-47931633 28 1.06e-04 CTGATGAATG GGGGCGTG GTTAGTGGAA chr2:242823872-242823952 53 1.06e-04 GGGCTGGACG GGGGCGTG GTCATGTGCG chr16:81130086-81130166 63 1.06e-04 ACGCGAAAGA GGGGCGTG GGCATGGGGA chr19:10981885-10981965 71 1.06e-04 AGGCCTCCGA GGGGCGTG CC chr1:994949-995029 73 1.06e-04 GCGTGGCCTC GGGGCGTG chr2:220417395-220417475 39 1.06e-04 GGCGGAGCCC GGGGCGTG AGCGGGGCGG chr6:170475741-170475821 73 1.06e-04 ggcccttctg ggggcgtg chr13:114428165-11442824 71 1.06e-04 TGCGGACCCA GGGGCGTG CA chr19:36505247-36505327 54 1.43e-04 CATTGGCAGG AGGGCGTG GGCGGGGCAT chr1:206138164-206138244 22 1.43e-04 AGAAGCGGGA AGGGCGTG CCTTGCCACT chr1:1229236-1229316 33 1.43e-04 CTCTTGGTCC AGGGCGTG CTGGTCCGCG chr11:13484820-13484900 72 2.13e-04 CGCCCAGGGG TGGGCGGG G chrX:48660186-48660266 30 2.13e-04 AGGCGGGATC TGGGCGGG CAGTCGAGAG chr22:19166343-19166423 40 2.13e-04 AACTGAGGCC TGGGCGGG GCGCGCCGAG chr19:38997754-38997834 30 2.13e-04 GAGTTCGAAA TGGGCGGG GCTTAAGCAC chr1:33647678-33647758 19 2.13e-04 CCCGCCCCCG TGGGCGGG ACCCAAGCAA chr19:1123168-1123248 10 2.13e-04 AGGTCCCGT TGGGCGGG TCATGGGCGT chr2:219773773-219773853 72 3.48e-04 CCGGAAGTGA GGGGCGGG C chr7:99775083-99775163 40 3.48e-04 GCTCGGCAGG GGGGCGGG ACCCGGCTGG chr6:30658712-30658792 65 3.48e-04 GGTGGGGAAA GGGGCGGG GTCGGGAT chr1:41826839-41826919 51 3.48e-04 CGCCGAGCAG GGGGCGGG GTCGCGCCAG chr13:114429472-11442955 11 3.48e-04 TTTGAGTTCA GGGGCGGG AGAATTTGTG chr1:227976204-227976284 9 3.48e-04 CGGGCCCG GGGGCGGG AGCAGGGCGT chr9:129987436-129987516 60 3.48e-04 CGAGGGGAGA GGGGCGGG ACGTGGGCTG chr12:132166841-13216692 59 3.48e-04 GGCCCAGACT GGGGCGGG AGGAAGGTGG chr17:40075316-40075396 52 4.19e-04 CCGCCCCACG AGGGCGGG CCCCGGGGCC chr10:104677948-10467802 37 4.19e-04 CCTGGCTGGG AGGGCGGG CACCCGCTTG chr16:57769533-57769613 1 4.19e-04 . AGGGCGGG TACTGAGGAA chr19:47950875-47950955 6 4.56e-04 CGTCG TGGGCATG GGTCACAGGC chr19:4556343-4556423 41 4.56e-04 GGATCCGCCC TGGGTGTG GTCACGGCCG chr19:7935738-7935818 57 5.29e-04 GTCTCCAGAT GGGGTGTG GTCAGGGGAG chr22:44588444-44588524 23 5.29e-04 CCTGCCCACT GGGGCATG GCCATCCTGT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGKG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:139237362-139237442 3.6e-05 19_[+5]_53 chr4:6597797-6597877 3.6e-05 64_[+5]_8 chr7:72847974-72848054 3.6e-05 70_[+5]_2 chr9:139916637-139916717 3.6e-05 63_[+5]_9 chr19:6678073-6678153 3.6e-05 29_[+5]_43 chrX:15756226-15756306 3.6e-05 47_[+5]_25 chr19:49866861-49866941 3.6e-05 57_[+5]_15 chr1:228362161-228362241 3.6e-05 23_[+5]_49 chr1:228361809-228361889 3.6e-05 71_[+5]_1 chr12:113659032-11365911 0.00011 36_[+5]_36 chr19:17650634-17650714 0.00011 41_[+5]_31 chr11:65641087-65641167 0.00011 7_[+5]_65 chr7:72298865-72298945 0.00011 56_[+5]_16 chr19:1045387-1045467 0.00011 38_[+5]_34 chr12:122277467-12227754 0.00011 20_[+5]_52 chr19:47760470-47760550 0.00011 15_[+5]_57 chr19:47931553-47931633 0.00011 27_[+5]_45 chr2:242823872-242823952 0.00011 52_[+5]_20 chr16:81130086-81130166 0.00011 62_[+5]_10 chr19:10981885-10981965 0.00011 70_[+5]_2 chr1:994949-995029 0.00011 72_[+5] chr2:220417395-220417475 0.00011 38_[+5]_34 chr6:170475741-170475821 0.00011 72_[+5] chr13:114428165-11442824 0.00011 70_[+5]_2 chr19:36505247-36505327 0.00014 53_[+5]_19 chr1:206138164-206138244 0.00014 21_[+5]_51 chr1:1229236-1229316 0.00014 32_[+5]_40 chr11:13484820-13484900 0.00021 71_[+5]_1 chrX:48660186-48660266 0.00021 29_[+5]_43 chr22:19166343-19166423 0.00021 39_[+5]_33 chr19:38997754-38997834 0.00021 29_[+5]_43 chr1:33647678-33647758 0.00021 18_[+5]_54 chr19:1123168-1123248 0.00021 9_[+5]_63 chr2:219773773-219773853 0.00035 71_[+5]_1 chr7:99775083-99775163 0.00035 39_[+5]_33 chr6:30658712-30658792 0.00035 64_[+5]_8 chr1:41826839-41826919 0.00035 50_[+5]_22 chr13:114429472-11442955 0.00035 10_[+5]_62 chr1:227976204-227976284 0.00035 8_[+5]_64 chr9:129987436-129987516 0.00035 59_[+5]_13 chr12:132166841-13216692 0.00035 58_[+5]_14 chr17:40075316-40075396 0.00042 51_[+5]_21 chr10:104677948-10467802 0.00042 36_[+5]_36 chr16:57769533-57769613 0.00042 [+5]_72 chr19:47950875-47950955 0.00046 5_[+5]_67 chr19:4556343-4556423 0.00046 40_[+5]_32 chr19:7935738-7935818 0.00053 56_[+5]_16 chr22:44588444-44588524 0.00053 22_[+5]_50 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGKG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF KGGGCGKG width=8 seqs=48 chr9:139237362-139237442 ( 20) TGGGCGTG 1 chr4:6597797-6597877 ( 65) TGGGCGTG 1 chr7:72847974-72848054 ( 71) TGGGCGTG 1 chr9:139916637-139916717 ( 64) TGGGCGTG 1 chr19:6678073-6678153 ( 30) TGGGCGTG 1 chrX:15756226-15756306 ( 48) TGGGCGTG 1 chr19:49866861-49866941 ( 58) TGGGCGTG 1 chr1:228362161-228362241 ( 24) TGGGCGTG 1 chr1:228361809-228361889 ( 72) TGGGCGTG 1 chr12:113659032-11365911 ( 37) GGGGCGTG 1 chr19:17650634-17650714 ( 42) GGGGCGTG 1 chr11:65641087-65641167 ( 8) GGGGCGTG 1 chr7:72298865-72298945 ( 57) GGGGCGTG 1 chr19:1045387-1045467 ( 39) GGGGCGTG 1 chr12:122277467-12227754 ( 21) GGGGCGTG 1 chr19:47760470-47760550 ( 16) GGGGCGTG 1 chr19:47931553-47931633 ( 28) GGGGCGTG 1 chr2:242823872-242823952 ( 53) GGGGCGTG 1 chr16:81130086-81130166 ( 63) GGGGCGTG 1 chr19:10981885-10981965 ( 71) GGGGCGTG 1 chr1:994949-995029 ( 73) GGGGCGTG 1 chr2:220417395-220417475 ( 39) GGGGCGTG 1 chr6:170475741-170475821 ( 73) GGGGCGTG 1 chr13:114428165-11442824 ( 71) GGGGCGTG 1 chr19:36505247-36505327 ( 54) AGGGCGTG 1 chr1:206138164-206138244 ( 22) AGGGCGTG 1 chr1:1229236-1229316 ( 33) AGGGCGTG 1 chr11:13484820-13484900 ( 72) TGGGCGGG 1 chrX:48660186-48660266 ( 30) TGGGCGGG 1 chr22:19166343-19166423 ( 40) TGGGCGGG 1 chr19:38997754-38997834 ( 30) TGGGCGGG 1 chr1:33647678-33647758 ( 19) TGGGCGGG 1 chr19:1123168-1123248 ( 10) TGGGCGGG 1 chr2:219773773-219773853 ( 72) GGGGCGGG 1 chr7:99775083-99775163 ( 40) GGGGCGGG 1 chr6:30658712-30658792 ( 65) GGGGCGGG 1 chr1:41826839-41826919 ( 51) GGGGCGGG 1 chr13:114429472-11442955 ( 11) GGGGCGGG 1 chr1:227976204-227976284 ( 9) GGGGCGGG 1 chr9:129987436-129987516 ( 60) GGGGCGGG 1 chr12:132166841-13216692 ( 59) GGGGCGGG 1 chr17:40075316-40075396 ( 52) AGGGCGGG 1 chr10:104677948-10467802 ( 37) AGGGCGGG 1 chr16:57769533-57769613 ( 1) AGGGCGGG 1 chr19:47950875-47950955 ( 6) TGGGCATG 1 chr19:4556343-4556423 ( 41) TGGGTGTG 1 chr19:7935738-7935818 ( 57) GGGGTGTG 1 chr22:44588444-44588524 ( 23) GGGGCATG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGKG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.66841 E= 3.7e-002 -47 -1223 67 106 -1223 -1223 161 -1223 -1223 -1223 161 -1223 -1223 -1223 161 -1223 -1223 154 -1223 -203 -205 -1223 155 -1223 -1223 -1223 11 193 -1223 -1223 161 -1223 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGKG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 48 E= 3.7e-002 0.125000 0.000000 0.520833 0.354167 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.958333 0.000000 0.041667 0.041667 0.000000 0.958333 0.000000 0.000000 0.000000 0.354167 0.645833 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGKG MEME-5 regular expression -------------------------------------------------------------------------------- [GT]GGGCG[TG]G -------------------------------------------------------------------------------- Time 18.54 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:132166841-13216692 9.99e-02 80 chr16:87594452-87594532 1.46e-01 80 chr1:228361809-228361889 3.68e-02 7_[+5(3.62e-05)]_8_[+5(3.62e-05)]_8_\ [+5(3.62e-05)]_8_[+5(3.62e-05)]_8_[+5(3.62e-05)]_1 chr13:114428165-11442824 6.36e-02 80 chr9:129987436-129987516 6.00e-02 80 chr7:155610381-155610461 7.01e-01 80 chr16:22202005-22202085 5.42e-01 80 chr8:143858985-143859065 5.59e-01 80 chr1:228362161-228362241 1.84e-02 7_[+5(3.62e-05)]_8_[+5(3.62e-05)]_8_\ [+5(3.62e-05)]_33 chr21:46825455-46825535 3.41e-01 80 chrX:1571976-1572056 2.17e-01 80 chr6:170475741-170475821 6.77e-02 80 chr6:169825686-169825766 8.10e-01 80 chr22:44588444-44588524 4.19e-02 80 chr19:4310846-4310926 9.64e-04 80 chr7:6543427-6543507 8.04e-01 80 chr16:84047811-84047891 3.30e-01 80 chr21:45848412-45848492 6.62e-02 80 chr3:128840883-128840963 3.66e-01 22_[+3(7.20e-05)]_50 chr19:8657396-8657476 1.54e-02 65_[+5(3.62e-05)]_7 chr19:50143574-50143654 4.86e-02 80 chr19:1123168-1123248 2.67e-02 20_[+5(3.62e-05)]_52 chr16:89653354-89653434 7.89e-01 80 chr19:49866861-49866941 6.55e-02 57_[+5(3.62e-05)]_15 chr6:37137819-37137899 2.82e-01 80 chr10:28592013-28592093 8.94e-03 80 chr2:17699717-17699797 4.01e-01 80 chr17:76136615-76136695 3.97e-02 80 chr2:220417395-220417475 8.61e-03 80 chrX:15756226-15756306 4.55e-02 47_[+5(3.62e-05)]_25 chr19:6678073-6678153 8.26e-03 29_[+5(3.62e-05)]_43 chrX:153042287-153042367 7.69e-01 80 chr20:62184746-62184826 3.32e-01 80 chr1:226033494-226033574 8.87e-02 1_[+4(6.61e-05)]_71 chr21:37528801-37528881 1.59e-01 80 chr10:48354863-48354943 2.81e-01 80 chr1:227976204-227976284 9.96e-02 80 chr9:139916637-139916717 3.30e-02 63_[+5(3.62e-05)]_9 chr1:33647678-33647758 1.28e-03 36_[+3(7.20e-05)]_36 chr19:12951512-12951592 5.49e-01 80 chr7:43622567-43622647 5.26e-01 80 chr20:61425853-61425933 1.13e-02 80 chr16:517788-517868 9.61e-01 80 chr1:175162067-175162147 6.82e-01 80 chr1:2517973-2518053 1.37e-01 80 chr19:3574021-3574101 3.56e-01 80 chr19:1063082-1063162 3.41e-01 80 chr19:49363467-49363547 2.32e-01 80 chr10:134093648-13409372 8.58e-01 80 chr19:7935738-7935818 6.92e-02 80 chr9:140044948-140045028 1.96e-01 2_[+3(7.20e-05)]_70 chr1:2126416-2126496 1.43e-01 80 chr1:994949-995029 1.71e-02 80 chr19:18747472-18747552 7.71e-01 80 chr7:25902185-25902265 2.61e-01 80 chr16:1393173-1393253 2.65e-01 80 chr19:7670529-7670609 1.40e-02 80 chr17:75277598-75277678 1.11e-01 80 chr19:55038334-55038414 5.19e-03 34_[+1(1.93e-05)]_30_[+1(3.94e-05)] chr19:4556343-4556423 2.54e-02 80 chr3:38066579-38066659 5.46e-02 80 chr7:130756967-130757047 1.27e-01 80 chr16:28947997-28948077 5.19e-03 34_[+3(7.20e-05)]_38 chr9:130981128-130981208 1.64e-01 80 chr19:10981885-10981965 2.52e-03 80 chr13:114429472-11442955 2.49e-01 80 chr19:36266323-36266403 1.63e-02 80 chr3:160116994-160117074 2.15e-02 80 chr1:1850856-1850936 5.49e-01 80 chrX:53711218-53711298 1.10e-04 24_[+4(2.99e-05)]_48 chr19:6767595-6767675 3.77e-01 16_[+3(7.20e-05)]_56 chr2:54483398-54483478 4.73e-03 7_[+1(1.93e-05)]_14_[+1(1.93e-05)]_\ 14_[+1(1.93e-05)]_21 chr1:231473942-231474022 2.62e-02 68_[+1(5.48e-05)]_4 chr19:38997754-38997834 4.32e-02 80 chr17:4843528-4843608 1.80e-03 25_[+1(1.93e-05)]_47 chr4:37688158-37688238 2.90e-01 80 chr7:44788255-44788335 2.84e-01 80 chr19:11616031-11616111 1.36e-01 80 chr15:34880670-34880750 6.53e-03 43_[+4(2.99e-05)]_29 chr4:3076179-3076259 2.02e-01 80 chr16:84048017-84048097 9.45e-02 80 chr19:56135832-56135912 5.15e-01 80 chr16:2955904-2955984 5.77e-02 80 chr11:134314449-13431452 2.71e-03 4_[+4(9.64e-05)]_39_[+1(2.93e-05)]_\ 21 chr1:41826839-41826919 4.42e-03 13_[+3(7.20e-05)]_50_[+3(7.20e-05)]_\ 1 chr1:31191051-31191131 2.71e-01 46_[+3(7.20e-05)]_26 chr19:9929873-9929953 7.58e-02 80 chr16:81130086-81130166 6.78e-02 80 chr12:49351290-49351370 6.63e-04 57_[+1(1.93e-05)]_15 chr19:1490880-1490960 6.60e-01 80 chr2:242823872-242823952 8.11e-02 80 chr6:97731134-97731214 1.66e-03 37_[+1(1.93e-05)]_35 chr1:21934437-21934517 5.82e-01 80 chr19:5687003-5687083 9.05e-01 80 chrX:153607311-153607391 1.20e-01 80 chr20:32581203-32581283 8.41e-01 80 chr9:130533677-130533757 1.38e-01 67_[+3(7.20e-05)]_5 chr22:19166343-19166423 1.81e-02 80 chr14:100705088-10070516 1.11e-04 67_[+1(1.93e-05)]_5 chr16:89768425-89768505 6.19e-02 80 chr5:114505661-114505741 1.93e-01 80 chr1:1229236-1229316 2.57e-01 80 chr4:103749178-103749258 6.46e-04 49_[+1(1.93e-05)]_23 chr15:44580889-44580969 2.03e-01 80 chr22:36784154-36784234 1.32e-01 80 chr19:47931553-47931633 2.92e-02 80 chr17:7760868-7760948 2.29e-04 7_[+4(2.99e-05)]_43_[+1(1.93e-05)]_\ 14 chr11:119773602-11977368 2.60e-03 32_[+1(2.93e-05)]_13_[+4(1.03e-05)]_\ 19 chr16:2186121-2186201 1.96e-02 18_[+3(7.20e-05)]_44_[+3(7.20e-05)]_\ 2 chr19:7985165-7985245 2.20e-01 35_[+3(7.20e-05)]_37 chr14:30766263-30766343 1.46e-03 22_[+1(2.93e-05)]_14_[+4(1.03e-05)]_\ 28 chr9:88555889-88555969 3.64e-03 29_[+1(1.93e-05)]_10_[+1(1.93e-05)]_\ 25 chr19:1455699-1455779 1.69e-01 80 chr6:167040932-167041012 2.47e-01 80 chr19:40971802-40971882 6.39e-02 80 chr17:4167251-4167331 3.45e-04 10_[+4(2.99e-05)]_43_[+1(1.93e-05)]_\ 11 chr11:1285835-1285915 7.67e-04 20_[+1(2.93e-05)]_14_[+4(1.03e-05)]_\ 30 chr17:79093576-79093656 4.38e-02 80 chr17:4900942-4901022 5.24e-01 80 chr7:72847974-72848054 6.77e-03 70_[+5(3.62e-05)]_2 chr6:30658712-30658792 2.15e-02 80 chr12:29534133-29534213 6.08e-03 49_[+1(1.93e-05)]_23 chr19:17320597-17320677 1.56e-02 80 chr7:138144729-138144809 5.71e-03 80 chr4:2845305-2845385 8.42e-01 80 chr10:3215384-3215464 1.01e-01 80 chr19:2900719-2900799 9.18e-01 80 chr19:47760470-47760550 3.31e-02 80 chr19:5904594-5904674 8.56e-03 80 chr12:122277467-12227754 2.64e-02 80 chr16:1993353-1993433 5.47e-01 80 chr11:67764410-67764490 4.08e-01 80 chr19:8590619-8590699 8.70e-01 80 chr19:9945797-9945877 8.94e-03 80 chr19:10946382-10946462 2.39e-01 80 chrX:48660186-48660266 1.85e-02 40_[+4(7.64e-05)]_32 chr22:42896211-42896291 4.36e-01 80 chr19:47950875-47950955 2.40e-02 80 chr19:39436129-39436209 3.29e-01 80 chr19:18633081-18633161 3.26e-01 80 chr4:4674905-4674985 4.36e-01 80 chr17:53046026-53046106 1.27e-04 29_[+1(1.93e-05)]_11_[+1(1.93e-05)]_\ 24 chr16:57769533-57769613 9.94e-02 80 chr7:99775083-99775163 1.72e-01 80 chr1:160068396-160068476 2.52e-01 20_[+3(7.20e-05)]_52 chr11:13484820-13484900 4.56e-07 40_[+1(1.93e-05)]_10_[+3(7.20e-05)]_\ 14 chr9:99212297-99212377 8.42e-01 80 chr19:1082572-1082652 2.96e-02 80 chr20:60813321-60813401 5.21e-03 80 chr19:17690766-17690846 4.97e-01 80 chr19:1045387-1045467 5.76e-03 80 chr8:144302021-144302101 3.81e-01 80 chr19:41076674-41076754 1.52e-01 80 chr7:157100650-157100730 1.83e-01 80 chr3:49131521-49131601 5.28e-03 1_[+4(6.07e-05)]_71 chr1:207226305-207226385 5.41e-04 22_[+1(1.93e-05)]_50 chr19:18315031-18315111 2.98e-02 80 chrX:109244182-109244262 1.94e-01 80 chr4:6597797-6597877 2.77e-02 47_[+5(3.62e-05)]_9_[+5(3.62e-05)]_\ 8 chr19:47164580-47164660 5.53e-01 80 chr1:232941064-232941144 2.37e-03 21_[+1(1.93e-05)]_32_[+1(2.93e-05)]_\ 11 chr16:27879170-27879250 3.86e-04 64_[+1(1.93e-05)]_8 chr19:8115582-8115662 2.81e-01 1_[+3(7.20e-05)]_71 chr11:67573297-67573377 8.16e-02 80 chr6:146285553-146285633 2.67e-03 57_[+1(1.93e-05)]_15 chr1:206138164-206138244 4.64e-02 80 chr7:72298865-72298945 6.99e-02 80 chr16:29888907-29888987 8.38e-01 80 chr19:51870879-51870959 6.86e-01 80 chr16:5148160-5148240 2.47e-01 80 chr2:97202327-97202407 1.10e-01 80 chr7:20837955-20838035 3.73e-01 80 chr10:104677948-10467802 1.48e-01 80 chr16:87526651-87526731 4.24e-01 80 chr10:135186890-13518697 1.03e-03 12_[+3(7.20e-05)]_30_[+4(2.99e-05)]_\ 22 chr9:139237362-139237442 3.08e-02 19_[+5(3.62e-05)]_14_[+5(3.62e-05)]_\ 31 chr5:34929452-34929532 5.91e-01 80 chr1:245508946-245509026 5.84e-03 27_[+1(2.93e-05)]_12_[+1(2.93e-05)]_\ 25 chr12:57940967-57941047 5.33e-04 7_[+1(1.93e-05)]_33_[+4(2.99e-05)]_\ 24 chr15:69452838-69452918 9.37e-03 80 chr11:65641087-65641167 1.42e-02 80 chr19:3285251-3285331 8.65e-01 80 chr19:10403091-10403171 4.89e-02 80 chr6:147981709-147981789 2.05e-05 58_[+1(1.93e-05)]_14 chr1:228247619-228247699 7.79e-02 80 chr5:176853453-176853533 2.58e-01 80 chr16:87985036-87985116 7.19e-03 17_[+1(1.93e-05)]_35_[+4(9.64e-05)]_\ 12 chr22:35627075-35627155 3.13e-04 15_[+1(2.93e-05)]_14_[+4(1.03e-05)]_\ 35 chr4:148605219-148605299 8.06e-01 80 chr19:48111962-48112042 1.05e-01 80 chr9:130159195-130159275 1.73e-01 21_[+3(7.20e-05)]_18_[+3(7.20e-05)]_\ 25 chr12:27091337-27091417 1.55e-02 51_[+1(1.93e-05)]_21 chr19:4124139-4124219 8.17e-04 22_[+1(1.93e-05)]_50 chr17:40075316-40075396 2.46e-03 39_[+3(7.20e-05)]_33 chr15:78730396-78730476 9.73e-04 3_[+4(2.99e-05)]_37_[+3(7.20e-05)]_\ 24 chr2:232759818-232759898 3.80e-04 18_[+1(2.93e-05)]_12_[+1(1.93e-05)]_\ 34 chrX:30907511-30907591 2.69e-02 53_[+1(1.93e-05)]_19 chr19:4328494-4328574 3.53e-01 80 chr8:124428714-124428794 1.72e-01 45_[+3(7.20e-05)]_27 chr6:52284958-52285038 5.86e-03 80 chr7:139677139-139677219 1.97e-03 29_[+1(2.93e-05)]_13_[+4(1.03e-05)]_\ 22 chr19:50249576-50249656 5.23e-01 80 chr14:29299352-29299432 6.17e-04 41_[+1(3.94e-05)]_31 chr5:125849880-125849960 4.85e-02 80 chr19:55538648-55538728 7.36e-01 80 chr1:3817918-3817998 4.66e-01 80 chr10:7830014-7830094 2.43e-02 21_[+4(2.99e-05)]_51 chr19:48996279-48996359 1.62e-01 47_[+3(7.20e-05)]_25 chr1:207224334-207224414 1.69e-03 40_[+4(2.99e-05)]_19_[+1(3.94e-05)]_\ 5 chr19:41304803-41304883 6.36e-01 80 chr16:2479199-2479279 1.24e-01 80 chrX:13752710-13752790 1.31e-04 23_[+1(1.93e-05)]_15_[+1(1.93e-05)]_\ 26 chr16:30411986-30412066 5.05e-04 51_[+1(1.93e-05)]_21 chr19:36505247-36505327 2.00e-02 80 chr2:136743187-136743267 3.96e-04 8_[+4(2.99e-05)]_10_[+1(5.48e-05)]_\ 46 chr19:889065-889145 9.10e-01 80 chr19:17443594-17443674 5.36e-01 80 chr2:219773773-219773853 1.53e-04 28_[+4(2.99e-05)]_44 chr1:2064713-2064793 3.29e-01 23_[+3(7.20e-05)]_23_[+3(7.20e-05)]_\ 18 chr15:72410535-72410615 3.92e-01 80 chr12:131153973-13115405 5.90e-04 48_[+1(1.93e-05)]_14_[+4(1.03e-05)]_\ 2 chr19:19729572-19729652 6.57e-01 80 chr11:1283954-1284034 7.91e-01 80 chr15:45571501-45571581 3.65e-02 34_[+3(7.20e-05)]_38 chr19:45394284-45394364 1.66e-01 80 chr19:16739129-16739209 2.52e-01 80 chr17:79980926-79981006 2.30e-01 80 chr8:103251460-103251540 5.70e-01 80 chr9:140353824-140353904 1.31e-02 80 chr11:5526911-5526991 6.31e-04 10_[+1(2.93e-05)]_13_[+4(1.03e-05)]_\ 41 chr18:75705700-75705780 3.89e-04 18_[+1(2.93e-05)]_13_[+4(1.03e-05)]_\ 33 chr10:127408093-12740817 5.31e-03 80 chr16:20956640-20956720 2.47e-01 80 chr19:11457106-11457186 4.22e-01 80 chr5:169010699-169010779 1.90e-03 22_[+1(2.93e-05)]_50 chr8:145596549-145596629 6.14e-01 80 chr16:54963156-54963236 2.52e-01 80 chr19:14629428-14629508 7.16e-02 80 chr14:104181913-10418199 3.79e-01 80 chr12:50561239-50561319 5.04e-01 80 chr1:145516258-145516338 2.16e-01 80 chr19:33166125-33166205 8.78e-01 80 chr19:17650634-17650714 2.72e-02 80 chr12:113659032-11365911 1.32e-02 80 chr10:102820514-10282059 1.68e-02 18_[+1(1.93e-05)]_54 chr19:3914382-3914462 8.44e-03 4_[+4(4.05e-05)]_11_[+4(2.99e-05)]_\ 49 chr21:47673702-47673782 7.21e-04 27_[+1(7.02e-05)]_9_[+4(2.99e-05)]_\ 28 chr11:72525255-72525335 2.93e-01 80 chr8:12051766-12051846 2.58e-01 80 chr20:35064801-35064881 1.52e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n10.farnam.hpc.yale.internal ********************************************************************************