******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/SIN3B.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr16:67596526-67596606 1.0000 80 chr14:23938935-23939015 1.0000 80 chr5:176730833-176730913 1.0000 80 chr9:131133703-131133783 1.0000 80 chr13:21476793-21476873 1.0000 80 chr17:7155186-7155266 1.0000 80 chr10:103543066-10354314 1.0000 80 chr5:60240799-60240879 1.0000 80 chrX:135579443-135579523 1.0000 80 chr14:68283219-68283299 1.0000 80 chr1:7831444-7831524 1.0000 80 chr19:34012564-34012644 1.0000 80 chr19:5977951-5978031 1.0000 80 chr3:122101958-122102038 1.0000 80 chr14:99947780-99947860 1.0000 80 chr17:45569689-45569769 1.0000 80 chr20:49575460-49575540 1.0000 80 chr3:194991722-194991802 1.0000 80 chr17:36453195-36453275 1.0000 80 chr14:71067279-71067359 1.0000 80 chr10:102027343-10202742 1.0000 80 chr1:894515-894595 1.0000 80 chr20:18447991-18448071 1.0000 80 chr17:60501279-60501359 1.0000 80 chr7:56032353-56032433 1.0000 80 chr14:102786108-10278618 1.0000 80 chr11:47198286-47198366 1.0000 80 chr1:151735881-151735961 1.0000 80 chr19:1848386-1848466 1.0000 80 chr7:102119285-102119365 1.0000 80 chr5:139682546-139682626 1.0000 80 chr22:44351329-44351409 1.0000 80 chrX:54466847-54466927 1.0000 80 chr17:42767016-42767096 1.0000 80 chr12:53645962-53646042 1.0000 80 chr1:155179075-155179155 1.0000 80 chr11:119205302-11920538 1.0000 80 chr22:42977906-42977986 1.0000 80 chr9:139377396-139377476 1.0000 80 chr7:102212877-102212957 1.0000 80 chr10:51827656-51827736 1.0000 80 chr22:50946695-50946775 1.0000 80 chr20:56884845-56884925 1.0000 80 chr9:6015527-6015607 1.0000 80 chr12:124155728-12415580 1.0000 80 chr16:70557311-70557391 1.0000 80 chr1:154244905-154244985 1.0000 80 chr9:139305153-139305233 1.0000 80 chr19:45394562-45394642 1.0000 80 chr16:89160234-89160314 1.0000 80 chr12:120876000-12087608 1.0000 80 chr17:80009799-80009879 1.0000 80 chr8:145743350-145743430 1.0000 80 chr3:49131375-49131455 1.0000 80 chr2:242626096-242626176 1.0000 80 chr12:108954814-10895489 1.0000 80 chr12:108956420-10895650 1.0000 80 chr14:55878434-55878514 1.0000 80 chr2:130939068-130939148 1.0000 80 chr16:5083832-5083912 1.0000 80 chr2:132250669-132250749 1.0000 80 chr3:49893850-49893930 1.0000 80 chr17:79213180-79213260 1.0000 80 chr11:1968610-1968690 1.0000 80 chr19:18747892-18747972 1.0000 80 chr20:2644748-2644828 1.0000 80 chr8:145150091-145150171 1.0000 80 chr3:186288514-186288594 1.0000 80 chr9:131591963-131592043 1.0000 80 chr16:31129024-31129104 1.0000 80 chr2:128615591-128615671 1.0000 80 chr9:94124056-94124136 1.0000 80 chr9:33076580-33076660 1.0000 80 chr7:1199792-1199872 1.0000 80 chr16:89574910-89574990 1.0000 80 chr19:37708937-37709017 1.0000 80 chr5:1345301-1345381 1.0000 80 chrX:100075436-100075516 1.0000 80 chr17:4607291-4607371 1.0000 80 chr10:120101721-12010180 1.0000 80 chr12:29533996-29534076 1.0000 80 chr20:55926355-55926435 1.0000 80 chr1:59165608-59165688 1.0000 80 chr2:232651165-232651245 1.0000 80 chr22:26908368-26908448 1.0000 80 chr19:9929393-9929473 1.0000 80 chr12:76953356-76953436 1.0000 80 chr22:32058116-32058196 1.0000 80 chr11:57480116-57480196 1.0000 80 chr16:620005-620085 1.0000 80 chr22:41864530-41864610 1.0000 80 chr22:42915661-42915741 1.0000 80 chr13:37573389-37573469 1.0000 80 chr19:13067894-13067974 1.0000 80 chr17:3572196-3572276 1.0000 80 chr19:13002001-13002081 1.0000 80 chr2:207630341-207630421 1.0000 80 chr5:64064798-64064878 1.0000 80 chr3:49761311-49761391 1.0000 80 chrX:52964190-52964270 1.0000 80 chr22:41347472-41347552 1.0000 80 chr19:41945652-41945732 1.0000 80 chr1:40204625-40204705 1.0000 80 chr13:64650009-64650089 1.0000 80 chr14:21458213-21458293 1.0000 80 chr16:88923570-88923650 1.0000 80 chr1:2322804-2322884 1.0000 80 chr16:70834946-70835026 1.0000 80 chr17:18218643-18218723 1.0000 80 chr3:139062908-139062988 1.0000 80 chr2:240964789-240964869 1.0000 80 chrX:19002966-19003046 1.0000 80 chr14:50583206-50583286 1.0000 80 chr7:66461889-66461969 1.0000 80 chr7:44058693-44058773 1.0000 80 chr17:56296538-56296618 1.0000 80 chr19:17378297-17378377 1.0000 80 chrX:55187451-55187531 1.0000 80 chr1:145826914-145826994 1.0000 80 chr16:67927292-67927372 1.0000 80 chr9:140149764-140149844 1.0000 80 chrX:152110221-152110301 1.0000 80 chr3:130465565-130465645 1.0000 80 chr11:47869779-47869859 1.0000 80 chr16:30773694-30773774 1.0000 80 chr3:196594839-196594919 1.0000 80 chr1:2343870-2343950 1.0000 80 chr15:89010493-89010573 1.0000 80 chrX:19362051-19362131 1.0000 80 chr7:25990672-25990752 1.0000 80 chr20:49574900-49574980 1.0000 80 chr8:146277895-146277975 1.0000 80 chr8:144691589-144691669 1.0000 80 chr17:2239646-2239726 1.0000 80 chr10:99205645-99205725 1.0000 80 chr8:17104268-17104348 1.0000 80 chr9:140446452-140446532 1.0000 80 chr1:100715287-100715367 1.0000 80 chr1:160254825-160254905 1.0000 80 chr5:137548901-137548981 1.0000 80 chr5:125936713-125936793 1.0000 80 chr20:5093645-5093725 1.0000 80 chr5:39074344-39074424 1.0000 80 chr10:124740002-12474008 1.0000 80 chr16:5121855-5121935 1.0000 80 chr2:242089974-242090054 1.0000 80 chr17:73258005-73258085 1.0000 80 chr2:98612239-98612319 1.0000 80 chr1:52082830-52082910 1.0000 80 chr17:36003330-36003410 1.0000 80 chr7:2353930-2354010 1.0000 80 chr16:2015058-2015138 1.0000 80 chr13:48669140-48669220 1.0000 80 chr1:162467680-162467760 1.0000 80 chr2:237994518-237994598 1.0000 80 chr9:139760810-139760890 1.0000 80 chr17:17380349-17380429 1.0000 80 chr3:135969233-135969313 1.0000 80 chr2:219536552-219536632 1.0000 80 chr4:151936765-151936845 1.0000 80 chr11:47587194-47587274 1.0000 80 chr1:202927303-202927383 1.0000 80 chr2:38604265-38604345 1.0000 80 chr8:143751338-143751418 1.0000 80 chr10:114206882-11420696 1.0000 80 chr15:75628378-75628458 1.0000 80 chr6:161412859-161412939 1.0000 80 chr17:80376388-80376468 1.0000 80 chr7:23339021-23339101 1.0000 80 chr16:23607527-23607607 1.0000 80 chr20:44044791-44044871 1.0000 80 chr3:45266591-45266671 1.0000 80 chr2:68290020-68290100 1.0000 80 chr11:85359044-85359124 1.0000 80 chr9:140100009-140100089 1.0000 80 chr22:41865155-41865235 1.0000 80 chr19:605260-605340 1.0000 80 chr17:74068511-74068591 1.0000 80 chr19:3626766-3626846 1.0000 80 chr1:38325150-38325230 1.0000 80 chr6:43655412-43655492 1.0000 80 chr11:67276027-67276107 1.0000 80 chr11:66610943-66611023 1.0000 80 chrX:108780111-108780191 1.0000 80 chr22:26879839-26879919 1.0000 80 chr17:79439043-79439123 1.0000 80 chr19:33572126-33572206 1.0000 80 chr16:2034242-2034322 1.0000 80 chr2:32503001-32503081 1.0000 80 chr7:45808624-45808704 1.0000 80 chr16:4475921-4476001 1.0000 80 chr6:20534739-20534819 1.0000 80 chr20:37591056-37591136 1.0000 80 chr7:149157634-149157714 1.0000 80 chr12:112820072-11282015 1.0000 80 chr1:75198898-75198978 1.0000 80 chr17:37910653-37910733 1.0000 80 chr5:5422884-5422964 1.0000 80 chr1:38273728-38273808 1.0000 80 chr13:52586552-52586632 1.0000 80 chr5:176943858-176943938 1.0000 80 chr12:27175534-27175614 1.0000 80 chr4:3076425-3076505 1.0000 80 chr2:200820531-200820611 1.0000 80 chr6:5261756-5261836 1.0000 80 chr20:48553002-48553082 1.0000 80 chr7:73097634-73097714 1.0000 80 chr17:73663434-73663514 1.0000 80 chr9:131843440-131843520 1.0000 80 chr11:69489990-69490070 1.0000 80 chr3:48488001-48488081 1.0000 80 chr8:145669617-145669697 1.0000 80 chr15:81282022-81282102 1.0000 80 chr19:57922564-57922644 1.0000 80 chr1:762736-762816 1.0000 80 chr16:771181-771261 1.0000 80 chr20:47538291-47538371 1.0000 80 chr1:24104952-24105032 1.0000 80 chr13:45563624-45563704 1.0000 80 chr19:893066-893146 1.0000 80 chr17:26684701-26684781 1.0000 80 chr3:48646976-48647056 1.0000 80 chr12:114404014-11440409 1.0000 80 chr11:28131823-28131903 1.0000 80 chr17:38210578-38210658 1.0000 80 chr12:122710465-12271054 1.0000 80 chr17:37607357-37607437 1.0000 80 chr11:237008-237088 1.0000 80 chr17:33288592-33288672 1.0000 80 chr8:22022244-22022324 1.0000 80 chr11:43665802-43665882 1.0000 80 chr16:88636834-88636914 1.0000 80 chr1:211848872-211848952 1.0000 80 chr17:37793519-37793599 1.0000 80 chr17:4167099-4167179 1.0000 80 chr3:185304178-185304258 1.0000 80 chr17:900375-900455 1.0000 80 chr1:161284219-161284299 1.0000 80 chr4:152682080-152682160 1.0000 80 chr19:7694361-7694441 1.0000 80 chr19:32836570-32836650 1.0000 80 chr16:23569149-23569229 1.0000 80 chr1:32110268-32110348 1.0000 80 chr11:6640526-6640606 1.0000 80 chr2:74710244-74710324 1.0000 80 chr17:685600-685680 1.0000 80 chr19:45681293-45681373 1.0000 80 chr5:177026988-177027068 1.0000 80 chr5:37379348-37379428 1.0000 80 chr10:102295744-10229582 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_SIN3B/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/SIN3B.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.159 C 0.342 G 0.341 T 0.159 Background letter frequencies (from file dataset with add-one prior applied): A 0.159 C 0.342 G 0.341 T 0.159 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TYTTACTT MEME-1 width = 8 sites = 12 llr = 124 E-value = 2.9e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif TYTTACTT MEME-1 Description -------------------------------------------------------------------------------- Simplified A 1::172:: pos.-specific C :3::183: probability G ::::3::: matrix T 97a9::8a bits 2.7 * * 2.4 * * 2.1 * ** * 1.9 * ** * Relative 1.6 * ** ** Entropy 1.3 **** ** (14.9 bits) 1.1 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel TTTTACTT consensus C G C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TYTTACTT MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr6:20534739-20534819 47 8.79e-07 TTGGACTGGT TTTTACTT CCCGACTTCT chr5:137548901-137548981 1 1.29e-06 . TTTTAATT TCCCGCAAAT chr1:160254825-160254905 14 3.18e-06 CACTATGGGC TCTTACTT TCCAGAAGCT chr4:3076425-3076505 26 6.95e-06 CAGGTTCTGC TTTTACCT GCGGCCCAGA chr1:38325150-38325230 47 6.95e-06 TAGTTTCGCC TTTTACCT CCGCGGCTCC chr12:29533996-29534076 46 6.95e-06 TGTTTCAGTA TTTTACCT TGTGTTATGG chr17:80009799-80009879 30 9.59e-06 GGTTCAGGTG TTTAACTT GCAGGTAACG chr12:114404014-11440409 37 1.05e-05 GTCCCCGCTG TTTTGATT CCAACACGAC chr10:114206882-11420696 3 1.32e-05 GC TTTTCCTT TGCGAACTTA chr10:99205645-99205725 18 1.73e-05 CGTTTAGCCT TCTTGCTT CAGCCCCTAT chr9:6015527-6015607 28 1.73e-05 CTGGTAAAAC TCTTGCTT TTCTGACACG chr7:102212877-102212957 36 3.09e-05 AGCCGGCGTC ACTTACTT CTCGCCCTCG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TYTTACTT MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr6:20534739-20534819 8.8e-07 46_[+1]_26 chr5:137548901-137548981 1.3e-06 [+1]_72 chr1:160254825-160254905 3.2e-06 13_[+1]_59 chr4:3076425-3076505 7e-06 25_[+1]_47 chr1:38325150-38325230 7e-06 46_[+1]_26 chr12:29533996-29534076 7e-06 45_[+1]_27 chr17:80009799-80009879 9.6e-06 29_[+1]_43 chr12:114404014-11440409 1e-05 36_[+1]_36 chr10:114206882-11420696 1.3e-05 2_[+1]_70 chr10:99205645-99205725 1.7e-05 17_[+1]_55 chr9:6015527-6015607 1.7e-05 27_[+1]_45 chr7:102212877-102212957 3.1e-05 35_[+1]_37 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TYTTACTT MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TYTTACTT width=8 seqs=12 chr6:20534739-20534819 ( 47) TTTTACTT 1 chr5:137548901-137548981 ( 1) TTTTAATT 1 chr1:160254825-160254905 ( 14) TCTTACTT 1 chr4:3076425-3076505 ( 26) TTTTACCT 1 chr1:38325150-38325230 ( 47) TTTTACCT 1 chr12:29533996-29534076 ( 46) TTTTACCT 1 chr17:80009799-80009879 ( 30) TTTAACTT 1 chr12:114404014-11440409 ( 37) TTTTGATT 1 chr10:114206882-11420696 ( 3) TTTTCCTT 1 chr10:99205645-99205725 ( 18) TCTTGCTT 1 chr9:6015527-6015607 ( 28) TCTTGCTT 1 chr7:102212877-102212957 ( 36) ACTTACTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TYTTACTT MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.6697 E= 2.9e+001 -93 -1023 -1023 253 -1023 -4 -1023 207 -1023 -1023 -1023 266 -93 -1023 -1023 253 207 -203 -45 -1023 7 129 -1023 -1023 -1023 -45 -1023 224 -1023 -1023 -1023 266 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TYTTACTT MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 12 E= 2.9e+001 0.083333 0.000000 0.000000 0.916667 0.000000 0.333333 0.000000 0.666667 0.000000 0.000000 0.000000 1.000000 0.083333 0.000000 0.000000 0.916667 0.666667 0.083333 0.250000 0.000000 0.166667 0.833333 0.000000 0.000000 0.000000 0.250000 0.000000 0.750000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TYTTACTT MEME-1 regular expression -------------------------------------------------------------------------------- T[TC]TT[AG]C[TC]T -------------------------------------------------------------------------------- Time 4.93 secs. ******************************************************************************** ******************************************************************************** MOTIF AAAMTGAA MEME-2 width = 8 sites = 10 llr = 107 E-value = 2.0e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAAMTGAA MEME-2 Description -------------------------------------------------------------------------------- Simplified A a996329a pos.-specific C :::3:::: probability G :111:8:: matrix T ::::7:1: bits 2.7 * * 2.4 * * 2.1 *** ** 1.9 *** * ** Relative 1.6 *** * ** Entropy 1.3 *** * ** (15.4 bits) 1.1 *** **** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel AAAATGAA consensus CAA sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAMTGAA MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr10:114206882-11420696 42 1.28e-06 GTCGGAGCGG AAAATAAA GCACGCACGC chr15:75628378-75628458 18 2.16e-06 GCGGGACCGG AAAAAGAA ATTCCCGGGC chr5:139682546-139682626 42 2.16e-06 CTCAGCCTCC AAAAAGAA GACCTCCGCC chr2:68290020-68290100 42 4.45e-06 AGCAGGAGAA AAACTGAA ACTACACCTT chr5:64064798-64064878 55 4.45e-06 TGATATTGAC AAACTGAA GCTTTCCTGC chr1:154244905-154244985 23 4.45e-06 CGGTCATAGG AAACTGAA AGTGCGTCAC chrX:152110221-152110301 24 9.97e-06 GACCGTCCAC AAAGTGAA ATGGCCGCCC chr14:71067279-71067359 32 1.04e-05 ATCAAGAGAC AAAATATA GCAATACAGT chr12:122710465-12271054 51 1.50e-05 CGGTACCTGA AGAATGAA GTTACGCTGC chr17:73663434-73663514 28 2.64e-05 GATGGCGGGG AAGAAGAA TGTTCTGTCG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAMTGAA MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr10:114206882-11420696 1.3e-06 41_[+2]_31 chr15:75628378-75628458 2.2e-06 17_[+2]_55 chr5:139682546-139682626 2.2e-06 41_[+2]_31 chr2:68290020-68290100 4.5e-06 41_[+2]_31 chr5:64064798-64064878 4.5e-06 54_[+2]_18 chr1:154244905-154244985 4.5e-06 22_[+2]_50 chrX:152110221-152110301 1e-05 23_[+2]_49 chr14:71067279-71067359 1e-05 31_[+2]_41 chr12:122710465-12271054 1.5e-05 50_[+2]_22 chr17:73663434-73663514 2.6e-05 27_[+2]_45 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAMTGAA MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAAMTGAA width=8 seqs=10 chr10:114206882-11420696 ( 42) AAAATAAA 1 chr15:75628378-75628458 ( 18) AAAAAGAA 1 chr5:139682546-139682626 ( 42) AAAAAGAA 1 chr2:68290020-68290100 ( 42) AAACTGAA 1 chr5:64064798-64064878 ( 55) AAACTGAA 1 chr1:154244905-154244985 ( 23) AAACTGAA 1 chrX:152110221-152110301 ( 24) AAAGTGAA 1 chr14:71067279-71067359 ( 32) AAAATATA 1 chr12:122710465-12271054 ( 51) AGAATGAA 1 chr17:73663434-73663514 ( 28) AAGAAGAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAMTGAA MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 12.3073 E= 2.0e+002 265 -997 -997 -997 250 -997 -177 -997 250 -997 -177 -997 192 -19 -177 -997 92 -997 -997 214 33 -997 123 -997 250 -997 -997 -66 265 -997 -997 -997 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAMTGAA MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 10 E= 2.0e+002 1.000000 0.000000 0.000000 0.000000 0.900000 0.000000 0.100000 0.000000 0.900000 0.000000 0.100000 0.000000 0.600000 0.300000 0.100000 0.000000 0.300000 0.000000 0.000000 0.700000 0.200000 0.000000 0.800000 0.000000 0.900000 0.000000 0.000000 0.100000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAMTGAA MEME-2 regular expression -------------------------------------------------------------------------------- AAA[AC][TA][GA]AA -------------------------------------------------------------------------------- Time 8.65 secs. ******************************************************************************** ******************************************************************************** MOTIF TTGATWTT MEME-3 width = 8 sites = 2 llr = 27 E-value = 4.4e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTGATWTT MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::a:5:: pos.-specific C :::::::: probability G ::a::::: matrix T aa::a5aa bits 2.7 ** ** ** 2.4 ** ** ** 2.1 ** ** ** 1.9 ** ** ** Relative 1.6 ******** Entropy 1.3 ******** (19.2 bits) 1.1 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel TTGATATT consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGATWTT MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr6:20534739-20534819 23 1.75e-06 GAGTGGCGGG TTGATTTT CTCACTTTGG chr5:139682546-139682626 9 1.75e-06 TGCCTCAC TTGATATT CTTGTCTATA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGATWTT MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr6:20534739-20534819 1.8e-06 22_[+3]_50 chr5:139682546-139682626 1.8e-06 8_[+3]_64 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGATWTT MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTGATWTT width=8 seqs=2 chr6:20534739-20534819 ( 23) TTGATTTT 1 chr5:139682546-139682626 ( 9) TTGATATT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGATWTT MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 13.1555 E= 4.4e+004 -765 -765 -765 265 -765 -765 -765 265 -765 -765 155 -765 265 -765 -765 -765 -765 -765 -765 265 165 -765 -765 165 -765 -765 -765 265 -765 -765 -765 265 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGATWTT MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 4.4e+004 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.500000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGATWTT MEME-3 regular expression -------------------------------------------------------------------------------- TTGAT[AT]TT -------------------------------------------------------------------------------- Time 12.28 secs. ******************************************************************************** ******************************************************************************** MOTIF AAGTWATT MEME-4 width = 8 sites = 2 llr = 27 E-value = 4.4e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAGTWATT MEME-4 Description -------------------------------------------------------------------------------- Simplified A aa::5a:: pos.-specific C :::::::: probability G ::a::::: matrix T :::a5:aa bits 2.7 ** * *** 2.4 ** * *** 2.1 ** * *** 1.9 ** * *** Relative 1.6 ******** Entropy 1.3 ******** (19.1 bits) 1.1 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel AAGTAATT consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGTWATT MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr5:37379348-37379428 51 1.75e-06 CATTTGCCGC AAGTTATT GGCAAGTTCC chrX:135579443-135579523 9 1.75e-06 TAGTTTAG AAGTAATT TCCTGACGTT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGTWATT MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr5:37379348-37379428 1.8e-06 50_[+4]_22 chrX:135579443-135579523 1.8e-06 8_[+4]_64 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGTWATT MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAGTWATT width=8 seqs=2 chr5:37379348-37379428 ( 51) AAGTTATT 1 chrX:135579443-135579523 ( 9) AAGTAATT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGTWATT MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 13.1555 E= 4.4e+004 265 -765 -765 -765 265 -765 -765 -765 -765 -765 155 -765 -765 -765 -765 265 165 -765 -765 165 265 -765 -765 -765 -765 -765 -765 265 -765 -765 -765 265 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGTWATT MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 4.4e+004 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.500000 0.000000 0.000000 0.500000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAGTWATT MEME-4 regular expression -------------------------------------------------------------------------------- AAGT[AT]ATT -------------------------------------------------------------------------------- Time 15.97 secs. ******************************************************************************** ******************************************************************************** MOTIF RCCATTTT MEME-5 width = 8 sites = 4 llr = 48 E-value = 7.9e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif RCCATTTT MEME-5 Description -------------------------------------------------------------------------------- Simplified A 5::a:::: pos.-specific C :aa::::: probability G 5::::::: matrix T ::::aaaa bits 2.7 ***** 2.4 ***** 2.1 ***** 1.9 ***** Relative 1.6 ******* Entropy 1.3 ******* (17.5 bits) 1.1 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel ACCATTTT consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCCATTTT MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:7694361-7694441 48 1.89e-06 CGCCATCACC ACCATTTT TCTGGATGCC chr3:185304178-185304258 54 1.89e-06 GATTCTCGGC ACCATTTT CCGTTTCTGC chr17:38210578-38210658 66 5.94e-06 GGTAGGCATC GCCATTTT GGCACTT chr13:48669140-48669220 70 5.94e-06 CGAAGACGCA GCCATTTT CCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCCATTTT MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:7694361-7694441 1.9e-06 47_[+5]_25 chr3:185304178-185304258 1.9e-06 53_[+5]_19 chr17:38210578-38210658 5.9e-06 65_[+5]_7 chr13:48669140-48669220 5.9e-06 69_[+5]_3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCCATTTT MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF RCCATTTT width=8 seqs=4 chr19:7694361-7694441 ( 48) ACCATTTT 1 chr3:185304178-185304258 ( 54) ACCATTTT 1 chr17:38210578-38210658 ( 66) GCCATTTT 1 chr13:48669140-48669220 ( 70) GCCATTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCCATTTT MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 12.1553 E= 7.9e+004 165 -865 55 -865 -865 155 -865 -865 -865 155 -865 -865 265 -865 -865 -865 -865 -865 -865 265 -865 -865 -865 265 -865 -865 -865 265 -865 -865 -865 265 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCCATTTT MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 7.9e+004 0.500000 0.000000 0.500000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCCATTTT MEME-5 regular expression -------------------------------------------------------------------------------- [AG]CCATTTT -------------------------------------------------------------------------------- Time 19.64 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr16:67596526-67596606 1.00e+00 80 chr14:23938935-23939015 2.69e-03 80 chr5:176730833-176730913 9.34e-01 80 chr9:131133703-131133783 8.31e-02 80 chr13:21476793-21476873 4.11e-01 80 chr17:7155186-7155266 7.27e-01 80 chr10:103543066-10354314 8.50e-01 80 chr5:60240799-60240879 2.95e-01 80 chrX:135579443-135579523 3.20e-04 8_[+4(1.75e-06)]_64 chr14:68283219-68283299 2.16e-03 80 chr1:7831444-7831524 9.11e-01 80 chr19:34012564-34012644 9.79e-01 80 chr19:5977951-5978031 8.71e-01 80 chr3:122101958-122102038 3.81e-01 80 chr14:99947780-99947860 8.65e-01 80 chr17:45569689-45569769 1.62e-02 80 chr20:49575460-49575540 1.06e-01 80 chr3:194991722-194991802 1.00e+00 80 chr17:36453195-36453275 9.90e-01 80 chr14:71067279-71067359 6.47e-03 31_[+2(1.04e-05)]_41 chr10:102027343-10202742 3.03e-01 80 chr1:894515-894595 5.20e-01 80 chr20:18447991-18448071 2.63e-01 80 chr17:60501279-60501359 6.35e-01 80 chr7:56032353-56032433 1.00e+00 80 chr14:102786108-10278618 1.00e+00 80 chr11:47198286-47198366 2.08e-01 80 chr1:151735881-151735961 3.97e-01 80 chr19:1848386-1848466 1.00e+00 80 chr7:102119285-102119365 4.52e-01 80 chr5:139682546-139682626 5.32e-07 8_[+3(1.75e-06)]_25_[+2(2.16e-06)]_\ 31 chr22:44351329-44351409 6.70e-01 80 chrX:54466847-54466927 4.24e-01 80 chr17:42767016-42767096 9.97e-01 80 chr12:53645962-53646042 1.00e+00 80 chr1:155179075-155179155 1.00e+00 80 chr11:119205302-11920538 4.18e-01 80 chr22:42977906-42977986 9.94e-01 80 chr9:139377396-139377476 1.00e+00 80 chr7:102212877-102212957 4.51e-03 35_[+1(3.09e-05)]_37 chr10:51827656-51827736 9.97e-01 80 chr22:50946695-50946775 9.58e-01 80 chr20:56884845-56884925 1.00e+00 80 chr9:6015527-6015607 2.79e-04 27_[+1(1.73e-05)]_45 chr12:124155728-12415580 6.31e-01 80 chr16:70557311-70557391 8.54e-01 80 chr1:154244905-154244985 2.55e-02 22_[+2(4.45e-06)]_50 chr9:139305153-139305233 6.32e-01 80 chr19:45394562-45394642 3.42e-01 80 chr16:89160234-89160314 4.98e-01 80 chr12:120876000-12087608 8.84e-01 80 chr17:80009799-80009879 7.82e-03 29_[+1(9.59e-06)]_43 chr8:145743350-145743430 1.00e+00 80 chr3:49131375-49131455 6.18e-01 80 chr2:242626096-242626176 3.56e-01 80 chr12:108954814-10895489 5.36e-01 80 chr12:108956420-10895650 1.00e+00 80 chr14:55878434-55878514 9.98e-01 80 chr2:130939068-130939148 7.24e-01 80 chr16:5083832-5083912 7.65e-01 80 chr2:132250669-132250749 8.87e-01 80 chr3:49893850-49893930 2.10e-01 80 chr17:79213180-79213260 1.00e+00 80 chr11:1968610-1968690 7.73e-01 80 chr19:18747892-18747972 9.02e-01 80 chr20:2644748-2644828 9.99e-01 80 chr8:145150091-145150171 1.00e+00 80 chr3:186288514-186288594 9.08e-01 80 chr9:131591963-131592043 3.93e-01 80 chr16:31129024-31129104 9.87e-01 80 chr2:128615591-128615671 4.85e-01 80 chr9:94124056-94124136 9.94e-01 80 chr9:33076580-33076660 1.73e-01 80 chr7:1199792-1199872 9.37e-01 80 chr16:89574910-89574990 1.00e+00 80 chr19:37708937-37709017 5.68e-01 80 chr5:1345301-1345381 1.00e+00 80 chrX:100075436-100075516 9.55e-02 80 chr17:4607291-4607371 9.98e-01 80 chr10:120101721-12010180 3.10e-01 80 chr12:29533996-29534076 8.56e-05 45_[+1(6.95e-06)]_27 chr20:55926355-55926435 5.02e-01 80 chr1:59165608-59165688 6.04e-01 80 chr2:232651165-232651245 9.56e-01 80 chr22:26908368-26908448 3.57e-02 80 chr19:9929393-9929473 5.31e-01 80 chr12:76953356-76953436 7.79e-01 80 chr22:32058116-32058196 5.60e-01 80 chr11:57480116-57480196 6.53e-02 80 chr16:620005-620085 1.00e+00 80 chr22:41864530-41864610 9.58e-01 80 chr22:42915661-42915741 9.97e-01 80 chr13:37573389-37573469 3.05e-02 80 chr19:13067894-13067974 1.00e+00 80 chr17:3572196-3572276 9.72e-01 80 chr19:13002001-13002081 9.84e-01 80 chr2:207630341-207630421 1.63e-01 80 chr5:64064798-64064878 4.38e-05 43_[+3(6.46e-05)]_3_[+2(4.45e-06)]_\ 18 chr3:49761311-49761391 6.38e-01 80 chrX:52964190-52964270 5.39e-01 80 chr22:41347472-41347552 5.07e-01 80 chr19:41945652-41945732 5.73e-01 80 chr1:40204625-40204705 8.63e-01 80 chr13:64650009-64650089 9.92e-01 80 chr14:21458213-21458293 7.16e-01 80 chr16:88923570-88923650 3.53e-01 80 chr1:2322804-2322884 3.61e-01 80 chr16:70834946-70835026 9.94e-01 80 chr17:18218643-18218723 8.15e-01 80 chr3:139062908-139062988 9.79e-01 80 chr2:240964789-240964869 1.00e+00 80 chrX:19002966-19003046 8.07e-01 80 chr14:50583206-50583286 8.98e-01 80 chr7:66461889-66461969 9.76e-01 80 chr7:44058693-44058773 6.59e-01 80 chr17:56296538-56296618 9.99e-01 80 chr19:17378297-17378377 4.75e-01 80 chrX:55187451-55187531 6.37e-02 80 chr1:145826914-145826994 1.02e-01 80 chr16:67927292-67927372 9.69e-01 80 chr9:140149764-140149844 1.00e+00 80 chrX:152110221-152110301 1.35e-02 23_[+2(9.97e-06)]_49 chr3:130465565-130465645 1.40e-01 80 chr11:47869779-47869859 3.80e-01 80 chr16:30773694-30773774 8.98e-01 80 chr3:196594839-196594919 9.04e-01 80 chr1:2343870-2343950 6.78e-01 80 chr15:89010493-89010573 8.67e-01 80 chrX:19362051-19362131 4.95e-01 80 chr7:25990672-25990752 9.53e-01 80 chr20:49574900-49574980 6.04e-02 80 chr8:146277895-146277975 5.00e-01 80 chr8:144691589-144691669 9.95e-01 80 chr17:2239646-2239726 3.65e-02 80 chr10:99205645-99205725 1.60e-02 17_[+1(1.73e-05)]_55 chr8:17104268-17104348 8.47e-01 80 chr9:140446452-140446532 9.94e-01 80 chr1:100715287-100715367 2.83e-01 80 chr1:160254825-160254905 5.00e-03 13_[+1(3.18e-06)]_59 chr5:137548901-137548981 2.18e-04 [+1(1.29e-06)]_72 chr5:125936713-125936793 3.46e-01 80 chr20:5093645-5093725 9.61e-01 80 chr5:39074344-39074424 9.94e-01 80 chr10:124740002-12474008 9.83e-01 80 chr16:5121855-5121935 2.29e-01 80 chr2:242089974-242090054 8.37e-01 80 chr17:73258005-73258085 8.19e-01 80 chr2:98612239-98612319 5.15e-01 80 chr1:52082830-52082910 4.61e-01 80 chr17:36003330-36003410 3.82e-01 80 chr7:2353930-2354010 1.00e+00 80 chr16:2015058-2015138 6.01e-02 80 chr13:48669140-48669220 1.09e-03 69_[+5(5.94e-06)]_3 chr1:162467680-162467760 9.99e-01 80 chr2:237994518-237994598 4.87e-01 80 chr9:139760810-139760890 7.67e-01 80 chr17:17380349-17380429 1.52e-01 80 chr3:135969233-135969313 9.88e-01 80 chr2:219536552-219536632 6.90e-01 80 chr4:151936765-151936845 8.66e-01 80 chr11:47587194-47587274 3.92e-01 80 chr1:202927303-202927383 9.87e-01 80 chr2:38604265-38604345 9.42e-01 80 chr8:143751338-143751418 9.41e-01 80 chr10:114206882-11420696 1.00e-07 2_[+1(1.32e-05)]_5_[+1(3.09e-05)]_\ 18_[+2(1.28e-06)]_31 chr15:75628378-75628458 4.37e-04 17_[+2(2.16e-06)]_55 chr6:161412859-161412939 4.19e-01 80 chr17:80376388-80376468 1.00e+00 80 chr7:23339021-23339101 9.93e-01 80 chr16:23607527-23607607 3.34e-01 80 chr20:44044791-44044871 7.87e-01 80 chr3:45266591-45266671 7.33e-01 80 chr2:68290020-68290100 1.27e-02 41_[+2(4.45e-06)]_31 chr11:85359044-85359124 6.83e-03 3_[+4(6.46e-05)]_69 chr9:140100009-140100089 9.51e-01 80 chr22:41865155-41865235 9.87e-01 80 chr19:605260-605340 6.15e-01 80 chr17:74068511-74068591 1.30e-01 80 chr19:3626766-3626846 9.81e-01 80 chr1:38325150-38325230 8.19e-03 46_[+1(6.95e-06)]_26 chr6:43655412-43655492 9.06e-01 80 chr11:67276027-67276107 4.91e-01 80 chr11:66610943-66611023 1.00e+00 80 chrX:108780111-108780191 2.49e-02 80 chr22:26879839-26879919 9.94e-01 80 chr17:79439043-79439123 5.53e-01 80 chr19:33572126-33572206 8.30e-01 80 chr16:2034242-2034322 2.36e-01 80 chr2:32503001-32503081 1.35e-01 80 chr7:45808624-45808704 8.47e-01 80 chr16:4475921-4476001 9.73e-01 80 chr6:20534739-20534819 5.84e-06 22_[+3(1.75e-06)]_16_[+1(8.79e-07)]_\ 26 chr20:37591056-37591136 8.50e-01 80 chr7:149157634-149157714 1.60e-02 80 chr12:112820072-11282015 1.00e+00 80 chr1:75198898-75198978 4.39e-01 80 chr17:37910653-37910733 9.44e-01 80 chr5:5422884-5422964 9.99e-01 80 chr1:38273728-38273808 1.00e+00 80 chr13:52586552-52586632 8.62e-02 35_[+4(6.46e-05)]_37 chr5:176943858-176943938 5.97e-01 80 chr12:27175534-27175614 2.62e-03 80 chr4:3076425-3076505 2.60e-03 25_[+1(6.95e-06)]_47 chr2:200820531-200820611 7.84e-01 80 chr6:5261756-5261836 6.96e-03 80 chr20:48553002-48553082 7.84e-01 80 chr7:73097634-73097714 6.95e-02 80 chr17:73663434-73663514 4.43e-02 27_[+2(2.64e-05)]_45 chr9:131843440-131843520 6.77e-01 80 chr11:69489990-69490070 8.95e-01 80 chr3:48488001-48488081 9.53e-01 80 chr8:145669617-145669697 1.42e-01 80 chr15:81282022-81282102 9.08e-01 80 chr19:57922564-57922644 6.75e-02 80 chr1:762736-762816 9.94e-01 80 chr16:771181-771261 9.83e-01 80 chr20:47538291-47538371 9.92e-01 80 chr1:24104952-24105032 8.75e-01 80 chr13:45563624-45563704 2.17e-03 80 chr19:893066-893146 5.59e-02 80 chr17:26684701-26684781 2.29e-01 80 chr3:48646976-48647056 2.51e-01 80 chr12:114404014-11440409 4.27e-03 36_[+1(1.05e-05)]_36 chr11:28131823-28131903 1.34e-01 80 chr17:38210578-38210658 5.64e-04 65_[+5(5.94e-06)]_7 chr12:122710465-12271054 1.16e-02 50_[+2(1.50e-05)]_22 chr17:37607357-37607437 2.11e-01 80 chr11:237008-237088 4.74e-02 80 chr17:33288592-33288672 1.23e-01 68_[+2(9.51e-05)]_4 chr8:22022244-22022324 9.91e-01 80 chr11:43665802-43665882 3.30e-01 80 chr16:88636834-88636914 3.14e-01 80 chr1:211848872-211848952 8.02e-01 80 chr17:37793519-37793599 9.30e-01 80 chr17:4167099-4167179 9.99e-01 80 chr3:185304178-185304258 1.36e-03 53_[+5(1.89e-06)]_19 chr17:900375-900455 1.00e+00 80 chr1:161284219-161284299 3.30e-02 80 chr4:152682080-152682160 2.09e-02 80 chr19:7694361-7694441 4.07e-03 47_[+5(1.89e-06)]_25 chr19:32836570-32836650 5.77e-01 80 chr16:23569149-23569229 6.21e-01 80 chr1:32110268-32110348 1.37e-01 80 chr11:6640526-6640606 1.25e-01 80 chr2:74710244-74710324 8.46e-01 80 chr17:685600-685680 8.49e-01 80 chr19:45681293-45681373 7.74e-01 80 chr5:177026988-177027068 3.18e-01 38_[+2(5.92e-05)]_34 chr5:37379348-37379428 1.84e-04 50_[+4(1.75e-06)]_22 chr10:102295744-10229582 1.98e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n10.farnam.hpc.yale.internal ********************************************************************************