******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/RELA.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr12:21387459-21387539 1.0000 80 chr6:147482527-147482607 1.0000 80 chr22:22901720-22901800 1.0000 80 chr7:150658259-150658339 1.0000 80 chr10:72434148-72434228 1.0000 80 chr1:95550052-95550132 1.0000 80 chr6:138186529-138186609 1.0000 80 chrX:4593878-4593958 1.0000 80 chr7:100037430-100037510 1.0000 80 chr4:90414674-90414754 1.0000 80 chr1:103120719-103120799 1.0000 80 chr1:22231238-22231318 1.0000 80 chr6:31704809-31704889 1.0000 80 chr2:216153652-216153732 1.0000 80 chr7:87020449-87020529 1.0000 80 chr2:169652870-169652950 1.0000 80 chr22:20244833-20244913 1.0000 80 chr14:44631525-44631605 1.0000 80 chr2:140622746-140622826 1.0000 80 chr20:45264236-45264316 1.0000 80 chr1:38026124-38026204 1.0000 80 chr9:126101919-126101999 1.0000 80 chr17:40466175-40466255 1.0000 80 chr15:89088962-89089042 1.0000 80 chr17:40260297-40260377 1.0000 80 chr11:2803201-2803281 1.0000 80 chr22:21357366-21357446 1.0000 80 chr2:55506451-55506531 1.0000 80 chr18:9874883-9874963 1.0000 80 chr7:140186587-140186667 1.0000 80 chr3:143315859-143315939 1.0000 80 chr6:26202640-26202720 1.0000 80 chr4:40206769-40206849 1.0000 80 chr15:78568930-78569010 1.0000 80 chr19:40778251-40778331 1.0000 80 chr3:14246246-14246326 1.0000 80 chr1:161527713-161527793 1.0000 80 chr7:149261804-149261884 1.0000 80 chr1:12493640-12493720 1.0000 80 chr18:9879075-9879155 1.0000 80 chr1:192093550-192093630 1.0000 80 chr5:172216654-172216734 1.0000 80 chr1:27835876-27835956 1.0000 80 chr1:246332969-246333049 1.0000 80 chr6:147486724-147486804 1.0000 80 chr11:3530978-3531058 1.0000 80 chr1:149362605-149362685 1.0000 80 chr19:19170624-19170704 1.0000 80 chr18:3655836-3655916 1.0000 80 chr6:145171146-145171226 1.0000 80 chr22:50557751-50557831 1.0000 80 chr16:53088438-53088518 1.0000 80 chr9:132619683-132619763 1.0000 80 chr2:56370258-56370338 1.0000 80 chr1:38464890-38464970 1.0000 80 chr7:50428449-50428529 1.0000 80 chr1:145030326-145030406 1.0000 80 chr4:127661918-127661998 1.0000 80 chr11:65419607-65419687 1.0000 80 chr12:23712806-23712886 1.0000 80 chr3:38040048-38040128 1.0000 80 chrX:154044969-154045049 1.0000 80 chr15:88212147-88212227 1.0000 80 chr7:76009960-76010040 1.0000 80 chr17:60248803-60248883 1.0000 80 chr15:39990934-39991014 1.0000 80 chr7:150019269-150019349 1.0000 80 chr6:7147564-7147644 1.0000 80 chr12:7165606-7165686 1.0000 80 chr3:44509710-44509790 1.0000 80 chr19:46081253-46081333 1.0000 80 chr3:9685963-9686043 1.0000 80 chr18:9005989-9006069 1.0000 80 chr6:34688146-34688226 1.0000 80 chr19:18475274-18475354 1.0000 80 chr6:37394927-37395007 1.0000 80 chr12:70484849-70484929 1.0000 80 chr5:148825468-148825548 1.0000 80 chr1:156725445-156725525 1.0000 80 chr1:27844711-27844791 1.0000 80 chr8:62632944-62633024 1.0000 80 chr14:35817182-35817262 1.0000 80 chr11:125422003-12542208 1.0000 80 chr9:100743748-100743828 1.0000 80 chr10:80937987-80938067 1.0000 80 chr10:12307537-12307617 1.0000 80 chr1:32644812-32644892 1.0000 80 chr8:59573590-59573670 1.0000 80 chr4:974860-974940 1.0000 80 chr6:26550551-26550631 1.0000 80 chr10:4909394-4909474 1.0000 80 chr4:138889147-138889227 1.0000 80 chr1:149362404-149362484 1.0000 80 chr6:10750945-10751025 1.0000 80 chr22:22378271-22378351 1.0000 80 chr6:96968431-96968511 1.0000 80 chr11:61601837-61601917 1.0000 80 chr19:39970220-39970300 1.0000 80 chr12:47601229-47601309 1.0000 80 chr1:207691855-207691935 1.0000 80 chr6:2734217-2734297 1.0000 80 chr11:71423994-71424074 1.0000 80 chr6:161632076-161632156 1.0000 80 chr5:74862554-74862634 1.0000 80 chr11:9341128-9341208 1.0000 80 chr21:31014992-31015072 1.0000 80 chr7:32703742-32703822 1.0000 80 chr9:99994452-99994532 1.0000 80 chr10:52085574-52085654 1.0000 80 chr1:28879079-28879159 1.0000 80 chr1:167130604-167130684 1.0000 80 chr20:1195571-1195651 1.0000 80 chr19:18485870-18485950 1.0000 80 chr7:66825021-66825101 1.0000 80 chr6:3024533-3024613 1.0000 80 chr6:37150681-37150761 1.0000 80 chrX:16604189-16604269 1.0000 80 chr11:91526395-91526475 1.0000 80 chr9:139684045-139684125 1.0000 80 chr4:73570828-73570908 1.0000 80 chr14:32490183-32490263 1.0000 80 chr1:142837706-142837786 1.0000 80 chr1:23807587-23807667 1.0000 80 chr19:12993633-12993713 1.0000 80 chr4:86880590-86880670 1.0000 80 chr2:38145094-38145174 1.0000 80 chr4:38319044-38319124 1.0000 80 chr21:45274762-45274842 1.0000 80 chr15:89081336-89081416 1.0000 80 chr10:52115811-52115891 1.0000 80 chr11:34852348-34852428 1.0000 80 chr10:74647998-74648078 1.0000 80 chr6:32014153-32014233 1.0000 80 chr3:150317854-150317934 1.0000 80 chr6:147207117-147207197 1.0000 80 chr6:36852549-36852629 1.0000 80 chr4:68568110-68568190 1.0000 80 chr11:109946713-10994679 1.0000 80 chr2:198795470-198795550 1.0000 80 chr19:50082604-50082684 1.0000 80 chr1:159047214-159047294 1.0000 80 chr20:23120333-23120413 1.0000 80 chr11:6714958-6715038 1.0000 80 chr1:142886448-142886528 1.0000 80 chr8:59585152-59585232 1.0000 80 chr18:9758825-9758905 1.0000 80 chr10:72421541-72421621 1.0000 80 chr1:11748774-11748854 1.0000 80 chr18:9895841-9895921 1.0000 80 chr6:37051734-37051814 1.0000 80 chr21:31021159-31021239 1.0000 80 chr20:49125602-49125682 1.0000 80 chr1:211396323-211396403 1.0000 80 chr8:61990524-61990604 1.0000 80 chr11:125431921-12543200 1.0000 80 chr19:14120059-14120139 1.0000 80 chr12:95856526-95856606 1.0000 80 chr3:183229615-183229695 1.0000 80 chr20:49548638-49548718 1.0000 80 chr16:88268077-88268157 1.0000 80 chr7:150708058-150708138 1.0000 80 chr6:15107780-15107860 1.0000 80 chr19:50877610-50877690 1.0000 80 chr3:101350899-101350979 1.0000 80 chr17:79934536-79934616 1.0000 80 chr5:95043479-95043559 1.0000 80 chr9:124048886-124048966 1.0000 80 chr18:8914294-8914374 1.0000 80 chr2:158075610-158075690 1.0000 80 chr1:173391899-173391979 1.0000 80 chr3:149293904-149293984 1.0000 80 chr9:132250104-132250184 1.0000 80 chr22:29136249-29136329 1.0000 80 chr17:40472441-40472521 1.0000 80 chr21:45204307-45204387 1.0000 80 chr20:45987416-45987496 1.0000 80 chr2:87816014-87816094 1.0000 80 chrX:4627178-4627258 1.0000 80 chr3:69063900-69063980 1.0000 80 chr14:102154568-10215464 1.0000 80 chr1:156663764-156663844 1.0000 80 chr3:14314361-14314441 1.0000 80 chr18:11941732-11941812 1.0000 80 chr16:70462973-70463053 1.0000 80 chr7:131010374-131010454 1.0000 80 chr17:25435103-25435183 1.0000 80 chr2:68834053-68834133 1.0000 80 chr15:34948362-34948442 1.0000 80 chr11:67044750-67044830 1.0000 80 chr8:29995073-29995153 1.0000 80 chr7:29834709-29834789 1.0000 80 chr8:62791539-62791619 1.0000 80 chr8:41668916-41668996 1.0000 80 chr6:43608026-43608106 1.0000 80 chr1:156151307-156151387 1.0000 80 chr7:156716298-156716378 1.0000 80 chr4:128551488-128551568 1.0000 80 chr2:158103719-158103799 1.0000 80 chr6:16236387-16236467 1.0000 80 chr3:44479429-44479509 1.0000 80 chr19:47848381-47848461 1.0000 80 chr5:36442466-36442546 1.0000 80 chr19:35411143-35411223 1.0000 80 chr7:511335-511415 1.0000 80 chr7:139615672-139615752 1.0000 80 chr15:66026093-66026173 1.0000 80 chr6:27027995-27028075 1.0000 80 chr6:37396509-37396589 1.0000 80 chr4:129607267-129607347 1.0000 80 chr3:186728433-186728513 1.0000 80 chr8:130091148-130091228 1.0000 80 chr15:89463541-89463621 1.0000 80 chr2:208657258-208657338 1.0000 80 chr3:14272378-14272458 1.0000 80 chr8:123842235-123842315 1.0000 80 chr2:120096531-120096611 1.0000 80 chr6:20273188-20273268 1.0000 80 chr13:23388677-23388757 1.0000 80 chr1:167729090-167729170 1.0000 80 chr1:12512384-12512464 1.0000 80 chr12:109085122-10908520 1.0000 80 chr19:49385479-49385559 1.0000 80 chr1:160511540-160511620 1.0000 80 chr2:69961302-69961382 1.0000 80 chr16:17176445-17176525 1.0000 80 chr9:100721172-100721252 1.0000 80 chr6:28454880-28454960 1.0000 80 chr2:169521327-169521407 1.0000 80 chr3:13036961-13037041 1.0000 80 chr5:139090143-139090223 1.0000 80 chr15:64188474-64188554 1.0000 80 chr11:44552540-44552620 1.0000 80 chr18:9803962-9804042 1.0000 80 chr18:3653996-3654076 1.0000 80 chr2:178029976-178030056 1.0000 80 chr17:75084065-75084145 1.0000 80 chr11:57679136-57679216 1.0000 80 chr15:35286197-35286277 1.0000 80 chr15:96100619-96100699 1.0000 80 chr3:5124092-5124172 1.0000 80 chr10:104215014-10421509 1.0000 80 chr4:144283986-144284066 1.0000 80 chr8:29952248-29952328 1.0000 80 chr8:37929478-37929558 1.0000 80 chr15:35992647-35992727 1.0000 80 chr6:3209979-3210059 1.0000 80 chr10:27530523-27530603 1.0000 80 chr1:46989691-46989771 1.0000 80 chr3:5037110-5037190 1.0000 80 chr1:27012720-27012800 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_RELA/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/RELA.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.256 C 0.25 G 0.236 T 0.259 Background letter frequencies (from file dataset with add-one prior applied): A 0.256 C 0.25 G 0.236 T 0.259 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF ARATGGAG MEME-1 width = 8 sites = 57 llr = 532 E-value = 1.0e-051 ******************************************************************************** -------------------------------------------------------------------------------- Motif ARATGGAG MEME-1 Description -------------------------------------------------------------------------------- Simplified A a4a:::9: pos.-specific C :::::1:: probability G :5:1a91a matrix T :::9:::: bits 2.1 * * 1.9 ** * 1.7 * ****** 1.5 * ****** Relative 1.3 * ****** Entropy 1.0 * ****** (13.5 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AGATGGAG consensus A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARATGGAG MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr15:35992647-35992727 13 1.35e-05 cccctattca agatggag ctgctctggt chr4:144283986-144284066 54 1.35e-05 gccccattca agatggag tcactctggt chr15:35286197-35286277 30 1.35e-05 tttgaaagta agatggag tcgattaggt chr11:57679136-57679216 29 1.35e-05 ctcctattca agatggag ttgctgtggt chr17:75084065-75084145 15 1.35e-05 cccctattca agatggag ttgctctggt chr16:17176445-17176525 9 1.35e-05 cctattca agatggag tcactctggt chr6:20273188-20273268 30 1.35e-05 cccttattca agatggag ttgctctggt chr2:120096531-120096611 19 1.35e-05 tcagtatcca agatggag ttgctttggc chr19:47848381-47848461 28 1.35e-05 ctcctgttca agatggag tcactctggt chr6:16236387-16236467 62 1.35e-05 gttaaaagca agatggag tcagttaggt chr4:128551488-128551568 39 1.35e-05 cccctattca agatggag tcgctctggt chr7:29834709-29834789 69 1.35e-05 ctcctattca agatggag ttgc chr17:25435103-25435183 70 1.35e-05 gttaaaggca agatggag tag chr21:45204307-45204387 4 1.35e-05 tca agatggag tcgctctggt chr4:86880590-86880670 37 1.35e-05 cccctattct agatggag ttgctatggt chr6:161632076-161632156 19 1.35e-05 gtaaaaagca agatggag tcagttacgt chr6:10750945-10751025 9 1.35e-05 aagagcca agatggag tctgtctggc chr4:138889147-138889227 28 1.35e-05 gttagaagca agatggag tcagttaggt chr10:12307537-12307617 22 1.35e-05 ctcctgttta agatggag ttgctctggt chr12:23712806-23712886 58 1.35e-05 TTATTAtttg agatggag tcttgccctg chr1:149362605-149362685 51 1.35e-05 cccctattca agatggag ttgctctggt chr11:3530978-3531058 29 1.35e-05 gaaagagcca agatggag tctgtctggc chr7:140186587-140186667 59 1.35e-05 gttagaagca agatggag tcagttaagt chr4:90414674-90414754 59 1.35e-05 ccgcttttca agatggag tcactgtggt chrX:4593878-4593958 45 1.35e-05 cccctattca agatggag ttgctctggt chr8:37929478-37929558 43 2.81e-05 gaaggagcca aaatggag tttgtctggc chr8:29952248-29952328 9 2.81e-05 agaaacca aaatggag tctgtcccgc chr10:104215014-10421509 5 2.81e-05 aaca aaatggag tctcctatgt chr13:23388677-23388757 9 2.81e-05 acagaaca aaatggag tctcttatgt chr3:44479429-44479509 40 2.81e-05 ccctcactca aaatggag tcgctctggt chr2:68834053-68834133 31 2.81e-05 cccttattca aaatggag tcactctggt chr3:183229615-183229695 32 2.81e-05 gtacaggtca aaatggag tttcttatgt chr11:125431921-12543200 71 2.81e-05 gaccaaacca aaatggag tt chr1:211396323-211396403 46 2.81e-05 gtacagaaca aaatggag tctcttatgt chr8:59585152-59585232 38 2.81e-05 gtatagaaca aaatggag tctcttatgt chr19:50082604-50082684 16 2.81e-05 gaccaaacca aaatggag acactcatgc chr6:36852549-36852629 10 2.81e-05 accaaacta aaatggag tcactcatgc chr11:9341128-9341208 54 2.81e-05 gtacagaaca aaatggag tctcttatgt chr6:26550551-26550631 19 2.81e-05 ccctcactca aaatggag tcgctctggt chr1:38026124-38026204 69 2.81e-05 gtacaggtca aaatggag tttc chr1:192093550-192093630 12 4.04e-05 tgaaaccagg agagggag cttgcagtga chr17:40466175-40466255 7 4.04e-05 AGCCTC AGAGGGAG GCCAGGTATA chr5:95043479-95043559 62 8.09e-05 gattaaagga aaagggag agtctaaaaa chr2:198795470-198795550 18 8.09e-05 ACCAGGACAC ATATGGAG GGGCATGTTT chr6:37150681-37150761 65 8.09e-05 cacatttcac agatgggg ataacaga chr3:44509710-44509790 29 8.09e-05 tataaaatcc aaagggag ggaCtgaaac chr1:95550052-95550132 41 8.09e-05 TCCTGTCAGC ATATGGAG GAAGCATGGC chr22:22901720-22901800 73 8.09e-05 GCTTCTGCAG AGATGGGG chr1:11748774-11748854 18 1.21e-04 gggctgggtc aaatgggg ttgggacttg chr6:32014153-32014233 15 1.34e-04 AGGCGCAGAG AGCTGGAG GTCTCCTCAG chr22:22378271-22378351 44 1.34e-04 GTGGCTGCAG AGCTGGAG GTGCAGATTG chr5:74862554-74862634 17 1.50e-04 cctcagttgg aaatgcag aaatcacctg chrX:154044969-154045049 50 1.50e-04 TCAAGACATT AAATGCAG GACTGACTCC chr2:56370258-56370338 73 1.50e-04 cctcagttgg aaatgcag chr17:79934536-79934616 31 1.64e-04 ACAGGCAGGC ACATGGAG AGAGGAGTGC chr8:123842235-123842315 21 1.78e-04 actccatctt gaatggag gctgggtaaa chr1:27835876-27835956 22 1.78e-04 tggttgaatt gaatggaG TCACCACCGT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARATGGAG MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr15:35992647-35992727 1.3e-05 12_[+1]_60 chr4:144283986-144284066 1.3e-05 53_[+1]_19 chr15:35286197-35286277 1.3e-05 29_[+1]_43 chr11:57679136-57679216 1.3e-05 28_[+1]_44 chr17:75084065-75084145 1.3e-05 14_[+1]_58 chr16:17176445-17176525 1.3e-05 8_[+1]_64 chr6:20273188-20273268 1.3e-05 29_[+1]_43 chr2:120096531-120096611 1.3e-05 18_[+1]_54 chr19:47848381-47848461 1.3e-05 27_[+1]_45 chr6:16236387-16236467 1.3e-05 61_[+1]_11 chr4:128551488-128551568 1.3e-05 38_[+1]_34 chr7:29834709-29834789 1.3e-05 68_[+1]_4 chr17:25435103-25435183 1.3e-05 69_[+1]_3 chr21:45204307-45204387 1.3e-05 3_[+1]_69 chr4:86880590-86880670 1.3e-05 36_[+1]_36 chr6:161632076-161632156 1.3e-05 18_[+1]_54 chr6:10750945-10751025 1.3e-05 8_[+1]_64 chr4:138889147-138889227 1.3e-05 27_[+1]_45 chr10:12307537-12307617 1.3e-05 21_[+1]_51 chr12:23712806-23712886 1.3e-05 57_[+1]_15 chr1:149362605-149362685 1.3e-05 50_[+1]_22 chr11:3530978-3531058 1.3e-05 28_[+1]_44 chr7:140186587-140186667 1.3e-05 58_[+1]_14 chr4:90414674-90414754 1.3e-05 58_[+1]_14 chrX:4593878-4593958 1.3e-05 44_[+1]_28 chr8:37929478-37929558 2.8e-05 42_[+1]_30 chr8:29952248-29952328 2.8e-05 8_[+1]_64 chr10:104215014-10421509 2.8e-05 4_[+1]_68 chr13:23388677-23388757 2.8e-05 8_[+1]_64 chr3:44479429-44479509 2.8e-05 39_[+1]_33 chr2:68834053-68834133 2.8e-05 30_[+1]_42 chr3:183229615-183229695 2.8e-05 31_[+1]_41 chr11:125431921-12543200 2.8e-05 70_[+1]_2 chr1:211396323-211396403 2.8e-05 45_[+1]_27 chr8:59585152-59585232 2.8e-05 37_[+1]_35 chr19:50082604-50082684 2.8e-05 15_[+1]_57 chr6:36852549-36852629 2.8e-05 9_[+1]_63 chr11:9341128-9341208 2.8e-05 53_[+1]_19 chr6:26550551-26550631 2.8e-05 18_[+1]_54 chr1:38026124-38026204 2.8e-05 68_[+1]_4 chr1:192093550-192093630 4e-05 11_[+1]_61 chr17:40466175-40466255 4e-05 6_[+1]_66 chr5:95043479-95043559 8.1e-05 61_[+1]_11 chr2:198795470-198795550 8.1e-05 17_[+1]_55 chr6:37150681-37150761 8.1e-05 64_[+1]_8 chr3:44509710-44509790 8.1e-05 28_[+1]_44 chr1:95550052-95550132 8.1e-05 40_[+1]_32 chr22:22901720-22901800 8.1e-05 72_[+1] chr1:11748774-11748854 0.00012 17_[+1]_55 chr6:32014153-32014233 0.00013 14_[+1]_58 chr22:22378271-22378351 0.00013 43_[+1]_29 chr5:74862554-74862634 0.00015 16_[+1]_56 chrX:154044969-154045049 0.00015 49_[+1]_23 chr2:56370258-56370338 0.00015 72_[+1] chr17:79934536-79934616 0.00016 30_[+1]_42 chr8:123842235-123842315 0.00018 20_[+1]_52 chr1:27835876-27835956 0.00018 21_[+1]_51 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARATGGAG MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ARATGGAG width=8 seqs=57 chr15:35992647-35992727 ( 13) AGATGGAG 1 chr4:144283986-144284066 ( 54) AGATGGAG 1 chr15:35286197-35286277 ( 30) AGATGGAG 1 chr11:57679136-57679216 ( 29) AGATGGAG 1 chr17:75084065-75084145 ( 15) AGATGGAG 1 chr16:17176445-17176525 ( 9) AGATGGAG 1 chr6:20273188-20273268 ( 30) AGATGGAG 1 chr2:120096531-120096611 ( 19) AGATGGAG 1 chr19:47848381-47848461 ( 28) AGATGGAG 1 chr6:16236387-16236467 ( 62) AGATGGAG 1 chr4:128551488-128551568 ( 39) AGATGGAG 1 chr7:29834709-29834789 ( 69) AGATGGAG 1 chr17:25435103-25435183 ( 70) AGATGGAG 1 chr21:45204307-45204387 ( 4) AGATGGAG 1 chr4:86880590-86880670 ( 37) AGATGGAG 1 chr6:161632076-161632156 ( 19) AGATGGAG 1 chr6:10750945-10751025 ( 9) AGATGGAG 1 chr4:138889147-138889227 ( 28) AGATGGAG 1 chr10:12307537-12307617 ( 22) AGATGGAG 1 chr12:23712806-23712886 ( 58) AGATGGAG 1 chr1:149362605-149362685 ( 51) AGATGGAG 1 chr11:3530978-3531058 ( 29) AGATGGAG 1 chr7:140186587-140186667 ( 59) AGATGGAG 1 chr4:90414674-90414754 ( 59) AGATGGAG 1 chrX:4593878-4593958 ( 45) AGATGGAG 1 chr8:37929478-37929558 ( 43) AAATGGAG 1 chr8:29952248-29952328 ( 9) AAATGGAG 1 chr10:104215014-10421509 ( 5) AAATGGAG 1 chr13:23388677-23388757 ( 9) AAATGGAG 1 chr3:44479429-44479509 ( 40) AAATGGAG 1 chr2:68834053-68834133 ( 31) AAATGGAG 1 chr3:183229615-183229695 ( 32) AAATGGAG 1 chr11:125431921-12543200 ( 71) AAATGGAG 1 chr1:211396323-211396403 ( 46) AAATGGAG 1 chr8:59585152-59585232 ( 38) AAATGGAG 1 chr19:50082604-50082684 ( 16) AAATGGAG 1 chr6:36852549-36852629 ( 10) AAATGGAG 1 chr11:9341128-9341208 ( 54) AAATGGAG 1 chr6:26550551-26550631 ( 19) AAATGGAG 1 chr1:38026124-38026204 ( 69) AAATGGAG 1 chr1:192093550-192093630 ( 12) AGAGGGAG 1 chr17:40466175-40466255 ( 7) AGAGGGAG 1 chr5:95043479-95043559 ( 62) AAAGGGAG 1 chr2:198795470-198795550 ( 18) ATATGGAG 1 chr6:37150681-37150761 ( 65) AGATGGGG 1 chr3:44509710-44509790 ( 29) AAAGGGAG 1 chr1:95550052-95550132 ( 41) ATATGGAG 1 chr22:22901720-22901800 ( 73) AGATGGGG 1 chr1:11748774-11748854 ( 18) AAATGGGG 1 chr6:32014153-32014233 ( 15) AGCTGGAG 1 chr22:22378271-22378351 ( 44) AGCTGGAG 1 chr5:74862554-74862634 ( 17) AAATGCAG 1 chrX:154044969-154045049 ( 50) AAATGCAG 1 chr2:56370258-56370338 ( 73) AAATGCAG 1 chr17:79934536-79934616 ( 31) ACATGGAG 1 chr8:123842235-123842315 ( 21) GAATGGAG 1 chr1:27835876-27835956 ( 22) GAATGGAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARATGGAG MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.55676 E= 1.0e-051 192 -1248 -275 -1248 66 -383 121 -288 192 -283 -1248 -1248 -1248 -1248 -175 185 -1248 -1248 208 -1248 -1248 -225 201 -1248 189 -1248 -216 -1248 -1248 -1248 208 -1248 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARATGGAG MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 57 E= 1.0e-051 0.964912 0.000000 0.035088 0.000000 0.403509 0.017544 0.543860 0.035088 0.964912 0.035088 0.000000 0.000000 0.000000 0.000000 0.070175 0.929825 0.000000 0.000000 1.000000 0.000000 0.000000 0.052632 0.947368 0.000000 0.947368 0.000000 0.052632 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARATGGAG MEME-1 regular expression -------------------------------------------------------------------------------- A[GA]ATGGAG -------------------------------------------------------------------------------- Time 5.05 secs. ******************************************************************************** ******************************************************************************** MOTIF GACTCCAT MEME-2 width = 8 sites = 42 llr = 403 E-value = 7.3e-033 ******************************************************************************** -------------------------------------------------------------------------------- Motif GACTCCAT MEME-2 Description -------------------------------------------------------------------------------- Simplified A 2a::::a: pos.-specific C ::a:aa:: probability G 7::::::: matrix T 1::a:::a bits 2.1 * ** 1.9 ** *** 1.7 ******* 1.5 ******* Relative 1.3 ******* Entropy 1.0 ******* (13.8 bits) 0.8 ******* 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GACTCCAT consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GACTCCAT MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:49385479-49385559 47 1.62e-05 GAACAGGGGC GACTCCAT Cttgaacagg chr6:37396509-37396589 47 1.62e-05 aaacatgagt gactccat tttgattttg chr19:35411143-35411223 3 1.62e-05 ga gactccat tttgttctgt chr1:156151307-156151387 7 1.62e-05 atagga gactccat tttgttctgt chr3:14314361-14314441 46 1.62e-05 agacataaga gactccat tttgttctgt chr3:101350899-101350979 50 1.62e-05 gagccagata gactccat cttggctcct chr12:95856526-95856606 2 1.62e-05 t gactccat tatgattctg chr20:49125602-49125682 3 1.62e-05 gt gactccat tttgattttt chr4:73570828-73570908 18 1.62e-05 agacctaacc gactccat cttgcttcta chrX:16604189-16604269 30 1.62e-05 gaaccagagt gactccat cttgaatagg chr7:66825021-66825101 43 1.62e-05 aaaccagagt gactccat tttgaatagg chr9:99994452-99994532 30 1.62e-05 agacataaga gactccat tttgttctgt chr11:71423994-71424074 42 1.62e-05 gagccagaca gactccat cttggctctt chr14:35817182-35817262 47 1.62e-05 gagccagaca gactccat cttggctttt chr19:46081253-46081333 61 1.62e-05 taacttgact gactccat cttacttcca chr12:7165606-7165686 65 1.62e-05 tagcatgggt gactccat cttgcctc chr15:88212147-88212227 28 1.62e-05 taacttaact gactccat cttgctttta chrX:154044969-154045049 62 1.62e-05 ATGCAGGACT GACTCCAT ATTGCCATTT chr1:192093550-192093630 73 1.62e-05 gacagagcga gactccat chr1:161527713-161527793 41 1.62e-05 cttagaaaaa gactccat tttatatttc chr2:55506451-55506531 20 1.62e-05 agacatggga gactccat tttgttctgt chr15:89088962-89089042 58 1.62e-05 gagccagaca gactccat cttggctctt chr20:45264236-45264316 53 1.62e-05 gaaccagagt gactccat cttgaacagg chr8:123842235-123842315 10 3.38e-05 aaccagagc aactccat cttgaatgga chr15:34948362-34948442 57 3.38e-05 gaaccagagc aactccat cttgaacagg chr3:69063900-69063980 41 3.38e-05 gaaccggagc aactccat cttaaatagg chrX:4627178-4627258 57 3.38e-05 agacctaacc aactccat cttgcttcta chr19:14120059-14120139 38 3.38e-05 gaaccagagc aactccat cttgaacagg chr4:68568110-68568190 32 3.38e-05 tagcacaagc aactccat tctggtttga chr4:38319044-38319124 44 3.38e-05 gaaccagagc aactccat cttgaatagg chr19:12993633-12993713 48 3.38e-05 tgacctaacc aactccat cttgccttta chr4:129607267-129607347 61 5.16e-05 taacttgagt tactccat attgctttgt chr1:23807587-23807667 43 5.16e-05 ggacatcagt tactccat cttatctgag chr14:32490183-32490263 55 5.16e-05 tagcttgagt tactccat actgctttgt chr7:150019269-150019349 56 5.16e-05 aagccagaat tactccat cttgaataag chr1:103120719-103120799 31 5.16e-05 gaaccagagc tactccat cttgaatagg chr12:109085122-10908520 25 8.24e-05 GCAAAACCGT GACTCCAG AAATGTGTTC chr2:87816014-87816094 66 8.24e-05 tgacgtaagt gacaccat cttagaa chr22:29136249-29136329 65 8.24e-05 tgtcctaaca gacaccat cttgctgt chr6:2734217-2734297 46 8.24e-05 ACGGACCACA GACTCCAG ACACTAGTGA chr7:131010374-131010454 46 9.96e-05 catgtgactg cactccat cctgggtgac chr1:156725445-156725525 68 1.15e-04 TGACAACTGT GCCTCCAT TGCCT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GACTCCAT MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:49385479-49385559 1.6e-05 46_[+2]_26 chr6:37396509-37396589 1.6e-05 46_[+2]_26 chr19:35411143-35411223 1.6e-05 2_[+2]_70 chr1:156151307-156151387 1.6e-05 6_[+2]_66 chr3:14314361-14314441 1.6e-05 45_[+2]_27 chr3:101350899-101350979 1.6e-05 49_[+2]_23 chr12:95856526-95856606 1.6e-05 1_[+2]_71 chr20:49125602-49125682 1.6e-05 2_[+2]_70 chr4:73570828-73570908 1.6e-05 17_[+2]_55 chrX:16604189-16604269 1.6e-05 29_[+2]_43 chr7:66825021-66825101 1.6e-05 42_[+2]_30 chr9:99994452-99994532 1.6e-05 29_[+2]_43 chr11:71423994-71424074 1.6e-05 41_[+2]_31 chr14:35817182-35817262 1.6e-05 46_[+2]_26 chr19:46081253-46081333 1.6e-05 60_[+2]_12 chr12:7165606-7165686 1.6e-05 64_[+2]_8 chr15:88212147-88212227 1.6e-05 27_[+2]_45 chrX:154044969-154045049 1.6e-05 61_[+2]_11 chr1:192093550-192093630 1.6e-05 72_[+2] chr1:161527713-161527793 1.6e-05 40_[+2]_32 chr2:55506451-55506531 1.6e-05 19_[+2]_53 chr15:89088962-89089042 1.6e-05 57_[+2]_15 chr20:45264236-45264316 1.6e-05 52_[+2]_20 chr8:123842235-123842315 3.4e-05 9_[+2]_63 chr15:34948362-34948442 3.4e-05 56_[+2]_16 chr3:69063900-69063980 3.4e-05 40_[+2]_32 chrX:4627178-4627258 3.4e-05 56_[+2]_16 chr19:14120059-14120139 3.4e-05 37_[+2]_35 chr4:68568110-68568190 3.4e-05 31_[+2]_41 chr4:38319044-38319124 3.4e-05 43_[+2]_29 chr19:12993633-12993713 3.4e-05 47_[+2]_25 chr4:129607267-129607347 5.2e-05 60_[+2]_12 chr1:23807587-23807667 5.2e-05 42_[+2]_30 chr14:32490183-32490263 5.2e-05 54_[+2]_18 chr7:150019269-150019349 5.2e-05 55_[+2]_17 chr1:103120719-103120799 5.2e-05 30_[+2]_42 chr12:109085122-10908520 8.2e-05 24_[+2]_48 chr2:87816014-87816094 8.2e-05 65_[+2]_7 chr22:29136249-29136329 8.2e-05 64_[+2]_8 chr6:2734217-2734297 8.2e-05 45_[+2]_27 chr7:131010374-131010454 0.0001 45_[+2]_27 chr1:156725445-156725525 0.00012 67_[+2]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GACTCCAT MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GACTCCAT width=8 seqs=42 chr19:49385479-49385559 ( 47) GACTCCAT 1 chr6:37396509-37396589 ( 47) GACTCCAT 1 chr19:35411143-35411223 ( 3) GACTCCAT 1 chr1:156151307-156151387 ( 7) GACTCCAT 1 chr3:14314361-14314441 ( 46) GACTCCAT 1 chr3:101350899-101350979 ( 50) GACTCCAT 1 chr12:95856526-95856606 ( 2) GACTCCAT 1 chr20:49125602-49125682 ( 3) GACTCCAT 1 chr4:73570828-73570908 ( 18) GACTCCAT 1 chrX:16604189-16604269 ( 30) GACTCCAT 1 chr7:66825021-66825101 ( 43) GACTCCAT 1 chr9:99994452-99994532 ( 30) GACTCCAT 1 chr11:71423994-71424074 ( 42) GACTCCAT 1 chr14:35817182-35817262 ( 47) GACTCCAT 1 chr19:46081253-46081333 ( 61) GACTCCAT 1 chr12:7165606-7165686 ( 65) GACTCCAT 1 chr15:88212147-88212227 ( 28) GACTCCAT 1 chrX:154044969-154045049 ( 62) GACTCCAT 1 chr1:192093550-192093630 ( 73) GACTCCAT 1 chr1:161527713-161527793 ( 41) GACTCCAT 1 chr2:55506451-55506531 ( 20) GACTCCAT 1 chr15:89088962-89089042 ( 58) GACTCCAT 1 chr20:45264236-45264316 ( 53) GACTCCAT 1 chr8:123842235-123842315 ( 10) AACTCCAT 1 chr15:34948362-34948442 ( 57) AACTCCAT 1 chr3:69063900-69063980 ( 41) AACTCCAT 1 chrX:4627178-4627258 ( 57) AACTCCAT 1 chr19:14120059-14120139 ( 38) AACTCCAT 1 chr4:68568110-68568190 ( 32) AACTCCAT 1 chr4:38319044-38319124 ( 44) AACTCCAT 1 chr19:12993633-12993713 ( 48) AACTCCAT 1 chr4:129607267-129607347 ( 61) TACTCCAT 1 chr1:23807587-23807667 ( 43) TACTCCAT 1 chr14:32490183-32490263 ( 55) TACTCCAT 1 chr7:150019269-150019349 ( 56) TACTCCAT 1 chr1:103120719-103120799 ( 31) TACTCCAT 1 chr12:109085122-10908520 ( 25) GACTCCAG 1 chr2:87816014-87816094 ( 66) GACACCAT 1 chr22:29136249-29136329 ( 65) GACACCAT 1 chr6:2734217-2734297 ( 46) GACTCCAG 1 chr7:131010374-131010454 ( 46) CACTCCAT 1 chr1:156725445-156725525 ( 68) GCCTCCAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GACTCCAT MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.74794 E= 7.3e-033 -43 -339 150 -112 193 -339 -1204 -1204 -1204 200 -1204 -1204 -242 -1204 -1204 188 -1204 200 -1204 -1204 -1204 200 -1204 -1204 197 -1204 -1204 -1204 -1204 -1204 -231 188 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GACTCCAT MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 42 E= 7.3e-033 0.190476 0.023810 0.666667 0.119048 0.976190 0.023810 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.047619 0.000000 0.000000 0.952381 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.047619 0.952381 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GACTCCAT MEME-2 regular expression -------------------------------------------------------------------------------- GACTCCAT -------------------------------------------------------------------------------- Time 8.78 secs. ******************************************************************************** ******************************************************************************** MOTIF CTCTGGTT MEME-3 width = 8 sites = 24 llr = 236 E-value = 2.2e-010 ******************************************************************************** -------------------------------------------------------------------------------- Motif CTCTGGTT MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C a:9::11: probability G ::1:a8:: matrix T :a:a:19a bits 2.1 * * 1.9 ** ** * 1.7 ** ** * 1.5 ***** ** Relative 1.3 ******** Entropy 1.0 ******** (14.2 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CTCTGGTT consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTCTGGTT MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr15:35992647-35992727 32 1.57e-05 tgctctggtg ctctggtt caaacacctc chr4:144283986-144284066 65 1.57e-05 gatggagtca ctctggtt caaatgcc chr17:75084065-75084145 26 1.57e-05 gatggagttg ctctggtt caaacgcctc chr16:17176445-17176525 20 1.57e-05 gatggagtca ctctggtt agagcacctc chr6:20273188-20273268 41 1.57e-05 gatggagttg ctctggtt caaatgcctc chr19:47848381-47848461 39 1.57e-05 gatggagtca ctctggtt cacatgcctc chr3:44479429-44479509 51 1.57e-05 aatggagtcg ctctggtt caaatacctc chr4:128551488-128551568 50 1.57e-05 gatggagtcg ctctggtt caaatgcctc chr2:68834053-68834133 42 1.57e-05 aatggagtca ctctggtt tgaatgcttc chr21:45204307-45204387 15 1.57e-05 gatggagtcg ctctggtt caaacacctc chr22:22378271-22378351 7 1.57e-05 gagtca ctctggtt ctaacacctc chr6:26550551-26550631 30 1.57e-05 aatggagtcg ctctggtt cgaatgcctc chr10:12307537-12307617 33 1.57e-05 gatggagttg ctctggtt caaacgcctc chr1:149362605-149362685 62 1.57e-05 gatggagttg ctctggtt caaacgcctc chrX:4593878-4593958 56 1.57e-05 gatggagttg ctctggtt caaatgcctc chr11:57679136-57679216 40 3.05e-05 gatggagttg ctgtggtt cacacgcctc chr19:49385479-49385559 1 3.05e-05 . CTGTGGTT TTCTCAGAGG chr4:90414674-90414754 70 3.05e-05 gatggagtca ctgtggtt tga chr6:37396509-37396589 73 6.22e-05 tgacaacttt ctctggct chr7:139615672-139615752 26 6.22e-05 TGTGCAATGT CTCTGCTT CATCTTGCTC chr9:132250104-132250184 47 6.22e-05 agaccctggg ctctggct tccctgtgct chr4:127661918-127661998 12 6.22e-05 ctacaccctc ctctgctt cctccagcca chr15:89081336-89081416 56 7.94e-05 tttttactaa ctctgttt ttagactctc chr15:89088962-89089042 18 7.94e-05 tttttactaa ctctgttt ttagactctc -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTCTGGTT MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr15:35992647-35992727 1.6e-05 31_[+3]_41 chr4:144283986-144284066 1.6e-05 64_[+3]_8 chr17:75084065-75084145 1.6e-05 25_[+3]_47 chr16:17176445-17176525 1.6e-05 19_[+3]_53 chr6:20273188-20273268 1.6e-05 40_[+3]_32 chr19:47848381-47848461 1.6e-05 38_[+3]_34 chr3:44479429-44479509 1.6e-05 50_[+3]_22 chr4:128551488-128551568 1.6e-05 49_[+3]_23 chr2:68834053-68834133 1.6e-05 41_[+3]_31 chr21:45204307-45204387 1.6e-05 14_[+3]_58 chr22:22378271-22378351 1.6e-05 6_[+3]_66 chr6:26550551-26550631 1.6e-05 29_[+3]_43 chr10:12307537-12307617 1.6e-05 32_[+3]_40 chr1:149362605-149362685 1.6e-05 61_[+3]_11 chrX:4593878-4593958 1.6e-05 55_[+3]_17 chr11:57679136-57679216 3e-05 39_[+3]_33 chr19:49385479-49385559 3e-05 [+3]_72 chr4:90414674-90414754 3e-05 69_[+3]_3 chr6:37396509-37396589 6.2e-05 72_[+3] chr7:139615672-139615752 6.2e-05 25_[+3]_47 chr9:132250104-132250184 6.2e-05 46_[+3]_26 chr4:127661918-127661998 6.2e-05 11_[+3]_61 chr15:89081336-89081416 7.9e-05 55_[+3]_17 chr15:89088962-89089042 7.9e-05 17_[+3]_55 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTCTGGTT MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CTCTGGTT width=8 seqs=24 chr15:35992647-35992727 ( 32) CTCTGGTT 1 chr4:144283986-144284066 ( 65) CTCTGGTT 1 chr17:75084065-75084145 ( 26) CTCTGGTT 1 chr16:17176445-17176525 ( 20) CTCTGGTT 1 chr6:20273188-20273268 ( 41) CTCTGGTT 1 chr19:47848381-47848461 ( 39) CTCTGGTT 1 chr3:44479429-44479509 ( 51) CTCTGGTT 1 chr4:128551488-128551568 ( 50) CTCTGGTT 1 chr2:68834053-68834133 ( 42) CTCTGGTT 1 chr21:45204307-45204387 ( 15) CTCTGGTT 1 chr22:22378271-22378351 ( 7) CTCTGGTT 1 chr6:26550551-26550631 ( 30) CTCTGGTT 1 chr10:12307537-12307617 ( 33) CTCTGGTT 1 chr1:149362605-149362685 ( 62) CTCTGGTT 1 chrX:4593878-4593958 ( 56) CTCTGGTT 1 chr11:57679136-57679216 ( 40) CTGTGGTT 1 chr19:49385479-49385559 ( 1) CTGTGGTT 1 chr4:90414674-90414754 ( 70) CTGTGGTT 1 chr6:37396509-37396589 ( 73) CTCTGGCT 1 chr7:139615672-139615752 ( 26) CTCTGCTT 1 chr9:132250104-132250184 ( 47) CTCTGGCT 1 chr4:127661918-127661998 ( 12) CTCTGCTT 1 chr15:89081336-89081416 ( 56) CTCTGTTT 1 chr15:89088962-89089042 ( 18) CTCTGTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTCTGGTT MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.0167 E= 2.2e-010 -1123 200 -1123 -1123 -1123 -1123 -1123 195 -1123 181 -91 -1123 -1123 -1123 -1123 195 -1123 -1123 208 -1123 -1123 -158 182 -163 -1123 -158 -1123 183 -1123 -1123 -1123 195 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTCTGGTT MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 24 E= 2.2e-010 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.875000 0.125000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.083333 0.833333 0.083333 0.000000 0.083333 0.000000 0.916667 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTCTGGTT MEME-3 regular expression -------------------------------------------------------------------------------- CTCTGGTT -------------------------------------------------------------------------------- Time 12.47 secs. ******************************************************************************** ******************************************************************************** MOTIF CCCAGCHC MEME-4 width = 8 sites = 28 llr = 255 E-value = 3.1e-007 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCCAGCHC MEME-4 Description -------------------------------------------------------------------------------- Simplified A :::a::3: pos.-specific C aaa::958 probability G ::::a1:2 matrix T ::::::31 bits 2.1 *** * 1.9 ***** 1.7 ****** 1.5 ****** Relative 1.3 ****** Entropy 1.0 ****** * (13.2 bits) 0.8 ****** * 0.6 ****** * 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CCCAGCCC consensus A sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCAGCHC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr4:144283986-144284066 40 1.47e-05 ccttatttta cccagccc cattcaagat chr18:3653996-3654076 39 1.47e-05 CACACGTCCC CCCAGCCC AACAACCGCA chr6:20273188-20273268 15 1.47e-05 ccttatttta cccagccc ttattcaaga chr3:44479429-44479509 25 1.47e-05 gcctcatttt cccagccc tcactcaaaa chr4:128551488-128551568 24 1.47e-05 ccttatttta cccagccc ctattcaaga chr2:38145094-38145174 67 1.47e-05 ccttatttta cccagccc ctattc chr4:86880590-86880670 22 1.47e-05 cctcgtttta cccagccc ctattctaga chr1:149362605-149362685 36 1.47e-05 ccttatttca cccagccc ctattcaaga chrX:4593878-4593958 30 1.47e-05 ccttatttta cccagccc ctattcaaga chr11:57679136-57679216 14 4.51e-05 ccttatttta cccagctc ctattcaaga chr2:169521327-169521407 67 4.51e-05 cctcatttta cccagctc ctattt chr3:186728433-186728513 49 4.51e-05 caagctgact cccagcac atccaagaat chr19:47848381-47848461 13 4.51e-05 ccttatttca cccagctc ctgttcaaga chr17:40472441-40472521 54 4.51e-05 cgcctgtaat cccagcac tttgggaggc chr3:150317854-150317934 33 4.51e-05 CGCTCAGCAC CCCAGCTC CATTTTccaa chr10:12307537-12307617 7 4.51e-05 atttta cccagctc ctgtttaaga chr19:40778251-40778331 32 4.51e-05 CAGCACAGCA CCCAGCAC GTGGAGACGG chr15:78568930-78569010 69 4.51e-05 CAGCCTGGGC CCCAGCAC CAGC chr6:31704809-31704889 39 4.51e-05 tgtctccggg cccagctc agcactagga chr4:90414674-90414754 44 5.91e-05 cctcatttta cccagccg cttttcaaga chr1:46989691-46989771 71 8.77e-05 GAGTGTGTCA CCCAGCTG GC chr7:511335-511415 58 8.77e-05 CCCCGTCTTC CCCAGCAG CCCATGAGCC chr12:47601229-47601309 69 8.77e-05 ACAAGGATGA CCCAGCAG ATGG chr2:169652870-169652950 35 8.77e-05 ACCGCTGGAC CCCAGCAG CTTGGCTAAG chr11:2803201-2803281 51 1.03e-04 TGCAGGCAGG CCCAGCCT CCCAGAATTG chr2:216153652-216153732 8 1.03e-04 gttcgag cccagcct ggccaacatg chr19:19170624-19170704 39 1.17e-04 CCCAGTATGG CCCAGGcc ttgcccattt chr22:22901720-22901800 37 1.17e-04 CCCACTTCCT CCCAGGCC CTCTAGGGGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCAGCHC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:144283986-144284066 1.5e-05 39_[+4]_33 chr18:3653996-3654076 1.5e-05 38_[+4]_34 chr6:20273188-20273268 1.5e-05 14_[+4]_58 chr3:44479429-44479509 1.5e-05 24_[+4]_48 chr4:128551488-128551568 1.5e-05 23_[+4]_49 chr2:38145094-38145174 1.5e-05 66_[+4]_6 chr4:86880590-86880670 1.5e-05 21_[+4]_51 chr1:149362605-149362685 1.5e-05 35_[+4]_37 chrX:4593878-4593958 1.5e-05 29_[+4]_43 chr11:57679136-57679216 4.5e-05 13_[+4]_59 chr2:169521327-169521407 4.5e-05 66_[+4]_6 chr3:186728433-186728513 4.5e-05 48_[+4]_24 chr19:47848381-47848461 4.5e-05 12_[+4]_60 chr17:40472441-40472521 4.5e-05 53_[+4]_19 chr3:150317854-150317934 4.5e-05 32_[+4]_40 chr10:12307537-12307617 4.5e-05 6_[+4]_66 chr19:40778251-40778331 4.5e-05 31_[+4]_41 chr15:78568930-78569010 4.5e-05 68_[+4]_4 chr6:31704809-31704889 4.5e-05 38_[+4]_34 chr4:90414674-90414754 5.9e-05 43_[+4]_29 chr1:46989691-46989771 8.8e-05 70_[+4]_2 chr7:511335-511415 8.8e-05 57_[+4]_15 chr12:47601229-47601309 8.8e-05 68_[+4]_4 chr2:169652870-169652950 8.8e-05 34_[+4]_38 chr11:2803201-2803281 0.0001 50_[+4]_22 chr2:216153652-216153732 0.0001 7_[+4]_65 chr19:19170624-19170704 0.00012 38_[+4]_34 chr22:22901720-22901800 0.00012 36_[+4]_36 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCAGCHC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCCAGCHC width=8 seqs=28 chr4:144283986-144284066 ( 40) CCCAGCCC 1 chr18:3653996-3654076 ( 39) CCCAGCCC 1 chr6:20273188-20273268 ( 15) CCCAGCCC 1 chr3:44479429-44479509 ( 25) CCCAGCCC 1 chr4:128551488-128551568 ( 24) CCCAGCCC 1 chr2:38145094-38145174 ( 67) CCCAGCCC 1 chr4:86880590-86880670 ( 22) CCCAGCCC 1 chr1:149362605-149362685 ( 36) CCCAGCCC 1 chrX:4593878-4593958 ( 30) CCCAGCCC 1 chr11:57679136-57679216 ( 14) CCCAGCTC 1 chr2:169521327-169521407 ( 67) CCCAGCTC 1 chr3:186728433-186728513 ( 49) CCCAGCAC 1 chr19:47848381-47848461 ( 13) CCCAGCTC 1 chr17:40472441-40472521 ( 54) CCCAGCAC 1 chr3:150317854-150317934 ( 33) CCCAGCTC 1 chr10:12307537-12307617 ( 7) CCCAGCTC 1 chr19:40778251-40778331 ( 32) CCCAGCAC 1 chr15:78568930-78569010 ( 69) CCCAGCAC 1 chr6:31704809-31704889 ( 39) CCCAGCTC 1 chr4:90414674-90414754 ( 44) CCCAGCCG 1 chr1:46989691-46989771 ( 71) CCCAGCTG 1 chr7:511335-511415 ( 58) CCCAGCAG 1 chr12:47601229-47601309 ( 69) CCCAGCAG 1 chr2:169652870-169652950 ( 35) CCCAGCAG 1 chr11:2803201-2803281 ( 51) CCCAGCCT 1 chr2:216153652-216153732 ( 8) CCCAGCCT 1 chr19:19170624-19170704 ( 39) CCCAGGCC 1 chr22:22901720-22901800 ( 37) CCCAGGCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCAGCHC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.5697 E= 3.1e-007 -1145 200 -1145 -1145 -1145 200 -1145 -1145 -1145 200 -1145 -1145 197 -1145 -1145 -1145 -1145 -1145 208 -1145 -1145 189 -172 -1145 -3 100 -1145 -5 -1145 159 -40 -185 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCAGCHC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 28 E= 3.1e-007 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.928571 0.071429 0.000000 0.250000 0.500000 0.000000 0.250000 0.000000 0.750000 0.178571 0.071429 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCAGCHC MEME-4 regular expression -------------------------------------------------------------------------------- CCCAGC[CAT]C -------------------------------------------------------------------------------- Time 16.14 secs. ******************************************************************************** ******************************************************************************** MOTIF SMCAGKRR MEME-5 width = 8 sites = 61 llr = 451 E-value = 6.6e-004 ******************************************************************************** -------------------------------------------------------------------------------- Motif SMCAGKRR MEME-5 Description -------------------------------------------------------------------------------- Simplified A :5:a:256 pos.-specific C 65a::::: probability G 4:::a354 matrix T :::::5:: bits 2.1 * * 1.9 *** 1.7 *** 1.5 *** Relative 1.3 *** Entropy 1.0 ***** ** (10.7 bits) 0.8 ***** ** 0.6 ***** ** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CACAGTAA consensus GC GGG sequence A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SMCAGKRR MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr10:104215014-10421509 42 3.15e-05 tctacacaga cacagtaa caatctgatc chr13:23388677-23388757 46 3.15e-05 tctacataga cacagtaa cagtctgatc chr20:49548638-49548718 54 3.15e-05 TCTTCCCAGT CACAGTGA TGGACTCTTC chr3:183229615-183229695 68 3.15e-05 tctacataga cacagtaa cagtc chr6:34688146-34688226 23 3.15e-05 tctatacaga cacagtaa caatctgatc chr6:147486724-147486804 63 3.15e-05 gcagatatgc cacagtga ccacttctca chr2:56370258-56370338 42 6.23e-05 tctgacaatc cccagtga gatgaacctg chr7:100037430-100037510 41 6.23e-05 TGTCCATGAA CCCAGTAA ACGCAATTCC chr6:43608026-43608106 63 9.11e-05 GTCGTCATGG CACAGGGA CACCGCAACT chr19:50877610-50877690 25 9.11e-05 ctcagtgtta cacaggaa ggaagtgaca chr22:21357366-21357446 62 9.11e-05 CCAGGTCTCC CACAGGGA CCACCGTGGG chr1:160511540-160511620 28 1.49e-04 AGTGTGGTTC CCCAGGAA AAACATTTTA chr15:89463541-89463621 53 1.49e-04 ttatgactca gacagtga aagagatcta chr6:16236387-16236467 24 1.49e-04 tcaacctaca cccaggaa tgaacaagga chr8:29995073-29995153 64 1.49e-04 ttataactga gacagtga aagaagtct chr17:25435103-25435183 32 1.49e-04 ttggcccatg cccaggaa tgactaagag chrX:4627178-4627258 31 1.49e-04 aggaaattat gacagtga aagaggtcag chr10:72421541-72421621 60 1.49e-04 tcctccctcc cccaggga ttgcctgacc chr11:6714958-6715038 3 1.49e-04 ga gacagtga aaagagatct chr1:142837706-142837786 65 1.49e-04 ccctatgttg cccaggga gctctgga chr19:18485870-18485950 49 1.49e-04 aggcCTGGAT GACAGTGA GAGACTCTGT chr11:125422003-12542208 29 1.49e-04 gtggccctca cccaggaa ttgacttggt chr3:44509710-44509790 70 1.49e-04 ttatgactga gacagtga aag chr12:7165606-7165686 39 1.49e-04 caaagatgat gacagtga gggaagtcta chr15:88212147-88212227 2 1.49e-04 a gacagtga aaaagatcta chr7:140186587-140186667 21 1.49e-04 tcagcctaca cccaggaa tgaaaaagga chr3:44479429-44479509 1 2.07e-04 . gccagtaa gtctcagcct chr21:45204307-45204387 59 2.07e-04 TTGTTTGACC CACAGTAG ATAAGCCTGA chr17:40472441-40472521 32 2.07e-04 TTAggccagg cacagtgg ctcacgcctg chr18:9758825-9758905 57 2.07e-04 GAAAGTGCAG CACAGTGG CTGGGACCGC chr9:132619683-132619763 64 2.07e-04 CGTGGAGGCT CACAGTGG AAGCACTGA chr11:3530978-3531058 13 2.07e-04 ggaagcggct gccagtga aagagccaag chr4:144283986-144284066 15 2.35e-04 ggcagggcag cccagtag gtctcagcct chr2:169521327-169521407 42 2.35e-04 gagagtgcag cccagtag gtttcagcct chr7:29834709-29834789 29 2.35e-04 gggaatgcag cccagtag gtctcagcct chr11:125431921-12543200 49 2.35e-04 tgaactaggc cccagtgg accagaccaa chr1:149362605-149362685 11 2.35e-04 gggaatgcag cccagtag gtctcagcct chr4:90414674-90414754 19 2.35e-04 gggaaagcaa cccagtag gtctcagcct chr11:65419607-65419687 41 2.63e-04 ggccagggct gacaggga aaaggagagg chr7:150658259-150658339 43 2.63e-04 AGGCCATGCT GACAGGGA GGCTGCAGGC chr8:41668916-41668996 60 3.47e-04 TCCCTCCTCA CACAGGAG CTGCCATTGC chr8:62791539-62791619 7 3.47e-04 GAAGAA GCCAGGGA AAATACAACA chr6:26550551-26550631 49 3.47e-04 gaatgcctct cacaGAAA TCCCGCTAAA chr6:145171146-145171226 13 3.47e-04 ACACCTGCTT CACAGGAG GGCCTCCCCT chr6:26202640-26202720 1 3.47e-04 . CACAGAGA TTGTGCCTGC chr7:131010374-131010454 4 4.30e-04 aaa cccaggag gtcaaggctg chr1:32644812-32644892 23 4.30e-04 gacattgagg cccagaga gagaacagaa chr12:21387459-21387539 41 4.30e-04 tcggcttaca cccagaaa tcaacaagaa chr15:35992647-35992727 61 4.57e-04 gacaGTACTG GCCAGTGG CATATAGTGG chr19:12993633-12993713 9 5.12e-04 aaaattat gacagaaa attatgtcag chr18:3655836-3655916 12 5.12e-04 CACATCAGGA GACAGAAA CAGACATGTT chr10:27530523-27530603 61 5.94e-04 attgcttgag gccaggag ttcaagacga chr9:100721172-100721252 63 5.94e-04 CAGGCAGCCA CACAGAGG ATTCTCATAG chr1:167729090-167729170 49 5.94e-04 ccgagaggta gccaggag ttagctcatg chr17:79934536-79934616 4 5.94e-04 CTA GCCAGGAG TCCGCAGAGA chr1:207691855-207691935 44 5.94e-04 cagtttggag gccagaaa tccagttaag chr11:67044750-67044830 58 6.22e-04 AAGATCTTTT CCCAGAAG CTGGGTGAGT chr11:57679136-57679216 59 6.49e-04 acacgcctct gacaGAAG GAATGGGGAG chr7:511335-511415 32 6.49e-04 AAGCAGGGGA GACAGAGG AGCTCTGGCC chr4:40206769-40206849 44 6.49e-04 gaatccagga gacagagg tttcagtgag chr19:14120059-14120139 15 6.75e-04 TGCCCTCTCt gccagagg cgtgtgaacc -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SMCAGKRR MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr10:104215014-10421509 3.2e-05 41_[+5]_31 chr13:23388677-23388757 3.2e-05 45_[+5]_27 chr20:49548638-49548718 3.2e-05 53_[+5]_19 chr3:183229615-183229695 3.2e-05 67_[+5]_5 chr6:34688146-34688226 3.2e-05 22_[+5]_50 chr6:147486724-147486804 3.2e-05 62_[+5]_10 chr2:56370258-56370338 6.2e-05 41_[+5]_31 chr7:100037430-100037510 6.2e-05 40_[+5]_32 chr6:43608026-43608106 9.1e-05 62_[+5]_10 chr19:50877610-50877690 9.1e-05 24_[+5]_48 chr22:21357366-21357446 9.1e-05 61_[+5]_11 chr1:160511540-160511620 0.00015 27_[+5]_45 chr15:89463541-89463621 0.00015 52_[+5]_20 chr6:16236387-16236467 0.00015 23_[+5]_49 chr8:29995073-29995153 0.00015 63_[+5]_9 chr17:25435103-25435183 0.00015 31_[+5]_41 chrX:4627178-4627258 0.00015 30_[+5]_42 chr10:72421541-72421621 0.00015 59_[+5]_13 chr11:6714958-6715038 0.00015 2_[+5]_70 chr1:142837706-142837786 0.00015 64_[+5]_8 chr19:18485870-18485950 0.00015 48_[+5]_24 chr11:125422003-12542208 0.00015 28_[+5]_44 chr3:44509710-44509790 0.00015 69_[+5]_3 chr12:7165606-7165686 0.00015 38_[+5]_34 chr15:88212147-88212227 0.00015 1_[+5]_71 chr7:140186587-140186667 0.00015 20_[+5]_52 chr3:44479429-44479509 0.00021 [+5]_72 chr21:45204307-45204387 0.00021 58_[+5]_14 chr17:40472441-40472521 0.00021 31_[+5]_41 chr18:9758825-9758905 0.00021 56_[+5]_16 chr9:132619683-132619763 0.00021 63_[+5]_9 chr11:3530978-3531058 0.00021 12_[+5]_60 chr4:144283986-144284066 0.00024 14_[+5]_58 chr2:169521327-169521407 0.00024 41_[+5]_31 chr7:29834709-29834789 0.00024 28_[+5]_44 chr11:125431921-12543200 0.00024 48_[+5]_24 chr1:149362605-149362685 0.00024 10_[+5]_62 chr4:90414674-90414754 0.00024 18_[+5]_54 chr11:65419607-65419687 0.00026 40_[+5]_32 chr7:150658259-150658339 0.00026 42_[+5]_30 chr8:41668916-41668996 0.00035 59_[+5]_13 chr8:62791539-62791619 0.00035 6_[+5]_66 chr6:26550551-26550631 0.00035 48_[+5]_24 chr6:145171146-145171226 0.00035 12_[+5]_60 chr6:26202640-26202720 0.00035 [+5]_72 chr7:131010374-131010454 0.00043 3_[+5]_69 chr1:32644812-32644892 0.00043 22_[+5]_50 chr12:21387459-21387539 0.00043 40_[+5]_32 chr15:35992647-35992727 0.00046 60_[+5]_12 chr19:12993633-12993713 0.00051 8_[+5]_64 chr18:3655836-3655916 0.00051 11_[+5]_61 chr10:27530523-27530603 0.00059 60_[+5]_12 chr9:100721172-100721252 0.00059 62_[+5]_10 chr1:167729090-167729170 0.00059 48_[+5]_24 chr17:79934536-79934616 0.00059 3_[+5]_69 chr1:207691855-207691935 0.00059 43_[+5]_29 chr11:67044750-67044830 0.00062 57_[+5]_15 chr11:57679136-57679216 0.00065 58_[+5]_14 chr7:511335-511415 0.00065 31_[+5]_41 chr4:40206769-40206849 0.00065 43_[+5]_29 chr19:14120059-14120139 0.00068 14_[+5]_58 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SMCAGKRR MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF SMCAGKRR width=8 seqs=61 chr10:104215014-10421509 ( 42) CACAGTAA 1 chr13:23388677-23388757 ( 46) CACAGTAA 1 chr20:49548638-49548718 ( 54) CACAGTGA 1 chr3:183229615-183229695 ( 68) CACAGTAA 1 chr6:34688146-34688226 ( 23) CACAGTAA 1 chr6:147486724-147486804 ( 63) CACAGTGA 1 chr2:56370258-56370338 ( 42) CCCAGTGA 1 chr7:100037430-100037510 ( 41) CCCAGTAA 1 chr6:43608026-43608106 ( 63) CACAGGGA 1 chr19:50877610-50877690 ( 25) CACAGGAA 1 chr22:21357366-21357446 ( 62) CACAGGGA 1 chr1:160511540-160511620 ( 28) CCCAGGAA 1 chr15:89463541-89463621 ( 53) GACAGTGA 1 chr6:16236387-16236467 ( 24) CCCAGGAA 1 chr8:29995073-29995153 ( 64) GACAGTGA 1 chr17:25435103-25435183 ( 32) CCCAGGAA 1 chrX:4627178-4627258 ( 31) GACAGTGA 1 chr10:72421541-72421621 ( 60) CCCAGGGA 1 chr11:6714958-6715038 ( 3) GACAGTGA 1 chr1:142837706-142837786 ( 65) CCCAGGGA 1 chr19:18485870-18485950 ( 49) GACAGTGA 1 chr11:125422003-12542208 ( 29) CCCAGGAA 1 chr3:44509710-44509790 ( 70) GACAGTGA 1 chr12:7165606-7165686 ( 39) GACAGTGA 1 chr15:88212147-88212227 ( 2) GACAGTGA 1 chr7:140186587-140186667 ( 21) CCCAGGAA 1 chr3:44479429-44479509 ( 1) GCCAGTAA 1 chr21:45204307-45204387 ( 59) CACAGTAG 1 chr17:40472441-40472521 ( 32) CACAGTGG 1 chr18:9758825-9758905 ( 57) CACAGTGG 1 chr9:132619683-132619763 ( 64) CACAGTGG 1 chr11:3530978-3531058 ( 13) GCCAGTGA 1 chr4:144283986-144284066 ( 15) CCCAGTAG 1 chr2:169521327-169521407 ( 42) CCCAGTAG 1 chr7:29834709-29834789 ( 29) CCCAGTAG 1 chr11:125431921-12543200 ( 49) CCCAGTGG 1 chr1:149362605-149362685 ( 11) CCCAGTAG 1 chr4:90414674-90414754 ( 19) CCCAGTAG 1 chr11:65419607-65419687 ( 41) GACAGGGA 1 chr7:150658259-150658339 ( 43) GACAGGGA 1 chr8:41668916-41668996 ( 60) CACAGGAG 1 chr8:62791539-62791619 ( 7) GCCAGGGA 1 chr6:26550551-26550631 ( 49) CACAGAAA 1 chr6:145171146-145171226 ( 13) CACAGGAG 1 chr6:26202640-26202720 ( 1) CACAGAGA 1 chr7:131010374-131010454 ( 4) CCCAGGAG 1 chr1:32644812-32644892 ( 23) CCCAGAGA 1 chr12:21387459-21387539 ( 41) CCCAGAAA 1 chr15:35992647-35992727 ( 61) GCCAGTGG 1 chr19:12993633-12993713 ( 9) GACAGAAA 1 chr18:3655836-3655916 ( 12) GACAGAAA 1 chr10:27530523-27530603 ( 61) GCCAGGAG 1 chr9:100721172-100721252 ( 63) CACAGAGG 1 chr1:167729090-167729170 ( 49) GCCAGGAG 1 chr17:79934536-79934616 ( 4) GCCAGGAG 1 chr1:207691855-207691935 ( 44) GCCAGAAA 1 chr11:67044750-67044830 ( 58) CCCAGAAG 1 chr11:57679136-57679216 ( 59) GACAGAAG 1 chr7:511335-511415 ( 32) GACAGAGG 1 chr4:40206769-40206849 ( 44) GACAGAGG 1 chr19:14120059-14120139 ( 15) GCCAGAGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SMCAGKRR MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.93691 E= 6.6e-004 -1257 128 74 -1257 108 88 -1257 -1257 -1257 200 -1257 -1257 197 -1257 -1257 -1257 -1257 -1257 208 -1257 -26 -1257 40 88 99 -1257 106 -1257 128 -1257 68 -1257 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SMCAGKRR MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 61 E= 6.6e-004 0.000000 0.606557 0.393443 0.000000 0.540984 0.459016 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.213115 0.000000 0.311475 0.475410 0.508197 0.000000 0.491803 0.000000 0.622951 0.000000 0.377049 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SMCAGKRR MEME-5 regular expression -------------------------------------------------------------------------------- [CG][AC]CAG[TGA][AG][AG] -------------------------------------------------------------------------------- Time 19.74 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:21387459-21387539 1.82e-01 80 chr6:147482527-147482607 9.56e-01 80 chr22:22901720-22901800 3.04e-03 72_[+1(8.09e-05)] chr7:150658259-150658339 3.67e-03 80 chr10:72434148-72434228 1.08e-01 80 chr1:95550052-95550132 1.01e-01 40_[+1(8.09e-05)]_32 chr6:138186529-138186609 2.11e-01 80 chrX:4593878-4593958 3.91e-06 29_[+4(1.47e-05)]_7_[+1(1.35e-05)]_\ 3_[+3(1.57e-05)]_17 chr7:100037430-100037510 2.83e-02 40_[+5(6.23e-05)]_32 chr4:90414674-90414754 9.11e-07 43_[+4(5.91e-05)]_7_[+1(1.35e-05)]_\ 3_[+3(3.05e-05)]_3 chr1:103120719-103120799 1.99e-01 30_[+2(5.16e-05)]_42 chr1:22231238-22231318 9.74e-02 80 chr6:31704809-31704889 7.08e-02 38_[+4(4.51e-05)]_34 chr2:216153652-216153732 4.80e-02 80 chr7:87020449-87020529 2.85e-01 80 chr2:169652870-169652950 2.90e-02 34_[+4(8.77e-05)]_38 chr22:20244833-20244913 1.88e-01 80 chr14:44631525-44631605 1.96e-01 80 chr2:140622746-140622826 1.73e-01 80 chr20:45264236-45264316 4.37e-03 52_[+2(1.62e-05)]_20 chr1:38026124-38026204 1.28e-01 68_[+1(2.81e-05)]_4 chr9:126101919-126101999 2.36e-01 80 chr17:40466175-40466255 6.53e-03 6_[+1(4.04e-05)]_66 chr15:89088962-89089042 1.42e-03 17_[+3(7.94e-05)]_32_[+2(1.62e-05)]_\ 15 chr17:40260297-40260377 4.90e-01 80 chr11:2803201-2803281 2.69e-03 80 chr22:21357366-21357446 4.05e-02 61_[+5(9.11e-05)]_11 chr2:55506451-55506531 1.64e-02 19_[+2(1.62e-05)]_53 chr18:9874883-9874963 9.12e-01 80 chr7:140186587-140186667 2.08e-03 58_[+1(1.35e-05)]_14 chr3:143315859-143315939 9.35e-01 80 chr6:26202640-26202720 7.08e-03 80 chr4:40206769-40206849 5.57e-02 80 chr15:78568930-78569010 2.01e-02 68_[+4(4.51e-05)]_4 chr19:40778251-40778331 6.99e-02 31_[+4(4.51e-05)]_41 chr3:14246246-14246326 1.63e-01 80 chr1:161527713-161527793 1.30e-01 22_[+2(3.38e-05)]_10_[+2(1.62e-05)]_\ 32 chr7:149261804-149261884 2.78e-01 80 chr1:12493640-12493720 5.21e-02 80 chr18:9879075-9879155 3.30e-01 80 chr1:192093550-192093630 4.34e-04 11_[+1(4.04e-05)]_53_[+2(1.62e-05)] chr5:172216654-172216734 2.19e-01 80 chr1:27835876-27835956 1.10e-01 80 chr1:246332969-246333049 8.66e-02 80 chr6:147486724-147486804 8.42e-03 62_[+5(3.15e-05)]_10 chr11:3530978-3531058 1.17e-03 28_[+1(1.35e-05)]_44 chr1:149362605-149362685 2.88e-07 35_[+4(1.47e-05)]_7_[+1(1.35e-05)]_\ 3_[+3(1.57e-05)]_11 chr19:19170624-19170704 1.74e-02 80 chr18:3655836-3655916 1.11e-01 80 chr6:145171146-145171226 5.35e-02 80 chr22:50557751-50557831 5.75e-01 80 chr16:53088438-53088518 3.07e-01 80 chr9:132619683-132619763 1.45e-01 80 chr2:56370258-56370338 5.40e-03 41_[+5(6.23e-05)]_31 chr1:38464890-38464970 1.97e-01 80 chr7:50428449-50428529 2.73e-02 80 chr1:145030326-145030406 6.49e-01 80 chr4:127661918-127661998 6.11e-03 11_[+3(6.22e-05)]_61 chr11:65419607-65419687 4.07e-02 80 chr12:23712806-23712886 4.19e-02 57_[+1(1.35e-05)]_15 chr3:38040048-38040128 1.05e-01 80 chrX:154044969-154045049 4.77e-03 61_[+2(1.62e-05)]_11 chr15:88212147-88212227 7.22e-04 27_[+2(1.62e-05)]_45 chr7:76009960-76010040 3.79e-01 80 chr17:60248803-60248883 4.28e-01 80 chr15:39990934-39991014 2.99e-01 80 chr7:150019269-150019349 4.56e-02 55_[+2(5.16e-05)]_17 chr6:7147564-7147644 2.52e-01 80 chr12:7165606-7165686 4.35e-03 64_[+2(1.62e-05)]_8 chr3:44509710-44509790 7.61e-03 28_[+1(8.09e-05)]_44 chr19:46081253-46081333 1.53e-02 60_[+2(1.62e-05)]_12 chr3:9685963-9686043 7.37e-01 80 chr18:9005989-9006069 1.33e-01 80 chr6:34688146-34688226 3.62e-02 22_[+5(3.15e-05)]_50 chr19:18475274-18475354 4.28e-02 80 chr6:37394927-37395007 5.20e-01 80 chr12:70484849-70484929 2.23e-01 80 chr5:148825468-148825548 2.15e-02 80 chr1:156725445-156725525 9.19e-03 80 chr1:27844711-27844791 2.28e-02 80 chr8:62632944-62633024 1.06e-01 80 chr14:35817182-35817262 9.75e-03 46_[+2(1.62e-05)]_26 chr11:125422003-12542208 5.25e-03 80 chr9:100743748-100743828 2.19e-01 80 chr10:80937987-80938067 3.68e-01 80 chr10:12307537-12307617 3.55e-06 6_[+4(4.51e-05)]_7_[+1(1.35e-05)]_3_\ [+3(1.57e-05)]_40 chr1:32644812-32644892 1.17e-01 80 chr8:59573590-59573670 3.39e-01 80 chr4:974860-974940 1.94e-01 80 chr6:26550551-26550631 5.38e-06 18_[+1(2.81e-05)]_3_[+3(1.57e-05)]_\ 43 chr10:4909394-4909474 7.19e-01 80 chr4:138889147-138889227 8.37e-02 27_[+1(1.35e-05)]_45 chr1:149362404-149362484 7.99e-01 80 chr6:10750945-10751025 1.84e-02 8_[+1(1.35e-05)]_64 chr22:22378271-22378351 3.84e-03 6_[+3(1.57e-05)]_66 chr6:96968431-96968511 2.66e-01 80 chr11:61601837-61601917 1.17e-01 80 chr19:39970220-39970300 6.69e-01 80 chr12:47601229-47601309 1.66e-02 68_[+4(8.77e-05)]_4 chr1:207691855-207691935 2.12e-01 80 chr6:2734217-2734297 1.09e-01 45_[+2(8.24e-05)]_27 chr11:71423994-71424074 9.75e-03 41_[+2(1.62e-05)]_31 chr6:161632076-161632156 2.26e-02 18_[+1(1.35e-05)]_54 chr5:74862554-74862634 7.94e-02 80 chr11:9341128-9341208 4.69e-02 53_[+1(2.81e-05)]_19 chr21:31014992-31015072 2.48e-01 80 chr7:32703742-32703822 8.25e-01 80 chr9:99994452-99994532 1.70e-02 29_[+2(1.62e-05)]_43 chr10:52085574-52085654 9.70e-01 80 chr1:28879079-28879159 2.31e-01 80 chr1:167130604-167130684 2.93e-01 80 chr20:1195571-1195651 4.92e-01 80 chr19:18485870-18485950 3.24e-03 80 chr7:66825021-66825101 1.60e-02 42_[+2(1.62e-05)]_30 chr6:3024533-3024613 6.67e-01 80 chr6:37150681-37150761 2.64e-02 64_[+1(8.09e-05)]_8 chrX:16604189-16604269 2.50e-02 29_[+2(1.62e-05)]_43 chr11:91526395-91526475 3.34e-01 80 chr9:139684045-139684125 2.05e-01 80 chr4:73570828-73570908 3.46e-03 17_[+2(1.62e-05)]_55 chr14:32490183-32490263 6.07e-02 54_[+2(5.16e-05)]_18 chr1:142837706-142837786 6.42e-02 80 chr1:23807587-23807667 1.29e-01 42_[+2(5.16e-05)]_30 chr19:12993633-12993713 2.02e-02 47_[+2(3.38e-05)]_25 chr4:86880590-86880670 3.34e-05 21_[+4(1.47e-05)]_7_[+1(1.35e-05)]_\ 36 chr2:38145094-38145174 9.81e-03 66_[+4(1.47e-05)]_6 chr4:38319044-38319124 6.12e-02 43_[+2(3.38e-05)]_29 chr21:45274762-45274842 2.23e-01 80 chr15:89081336-89081416 1.72e-01 55_[+3(7.94e-05)]_17 chr10:52115811-52115891 1.96e-01 80 chr11:34852348-34852428 1.30e-01 80 chr10:74647998-74648078 8.27e-01 80 chr6:32014153-32014233 6.94e-03 80 chr3:150317854-150317934 3.34e-02 32_[+4(4.51e-05)]_40 chr6:147207117-147207197 2.11e-01 80 chr6:36852549-36852629 7.95e-02 9_[+1(2.81e-05)]_63 chr4:68568110-68568190 6.40e-03 31_[+2(3.38e-05)]_41 chr11:109946713-10994679 3.19e-01 80 chr2:198795470-198795550 1.19e-01 17_[+1(8.09e-05)]_55 chr19:50082604-50082684 6.34e-02 15_[+1(2.81e-05)]_57 chr1:159047214-159047294 8.68e-01 80 chr20:23120333-23120413 4.00e-01 80 chr11:6714958-6715038 1.34e-02 80 chr1:142886448-142886528 2.04e-02 80 chr8:59585152-59585232 5.05e-02 37_[+1(2.81e-05)]_35 chr18:9758825-9758905 2.47e-02 80 chr10:72421541-72421621 2.45e-03 80 chr1:11748774-11748854 2.22e-02 80 chr18:9895841-9895921 3.80e-02 80 chr6:37051734-37051814 5.44e-01 80 chr21:31021159-31021239 3.26e-01 80 chr20:49125602-49125682 6.12e-02 2_[+2(1.62e-05)]_70 chr1:211396323-211396403 4.69e-02 45_[+1(2.81e-05)]_27 chr8:61990524-61990604 5.00e-01 80 chr11:125431921-12543200 5.08e-03 70_[+1(2.81e-05)]_2 chr19:14120059-14120139 5.57e-03 37_[+2(3.38e-05)]_35 chr12:95856526-95856606 3.46e-02 1_[+2(1.62e-05)]_71 chr3:183229615-183229695 3.63e-03 31_[+1(2.81e-05)]_28_[+5(3.15e-05)]_\ 5 chr20:49548638-49548718 3.29e-02 53_[+5(3.15e-05)]_19 chr16:88268077-88268157 1.97e-01 80 chr7:150708058-150708138 1.32e-01 80 chr6:15107780-15107860 9.03e-01 80 chr19:50877610-50877690 6.01e-03 24_[+5(9.11e-05)]_48 chr3:101350899-101350979 9.75e-03 49_[+2(1.62e-05)]_23 chr17:79934536-79934616 3.15e-02 80 chr5:95043479-95043559 1.71e-01 61_[+1(8.09e-05)]_11 chr9:124048886-124048966 5.62e-01 80 chr18:8914294-8914374 1.20e-01 80 chr2:158075610-158075690 2.30e-01 80 chr1:173391899-173391979 2.65e-01 80 chr3:149293904-149293984 5.46e-01 80 chr9:132250104-132250184 8.76e-02 46_[+3(6.22e-05)]_26 chr22:29136249-29136329 7.96e-02 64_[+2(8.24e-05)]_8 chr17:40472441-40472521 2.80e-03 53_[+4(4.51e-05)]_19 chr21:45204307-45204387 5.79e-05 3_[+1(1.35e-05)]_3_[+3(1.57e-05)]_\ 58 chr20:45987416-45987496 5.29e-01 80 chr2:87816014-87816094 1.29e-01 65_[+2(8.24e-05)]_7 chrX:4627178-4627258 6.42e-03 56_[+2(3.38e-05)]_16 chr3:69063900-69063980 7.57e-02 40_[+2(3.38e-05)]_32 chr14:102154568-10215464 3.13e-01 80 chr1:156663764-156663844 3.28e-01 80 chr3:14314361-14314441 4.53e-02 45_[+2(1.62e-05)]_27 chr18:11941732-11941812 1.26e-01 80 chr16:70462973-70463053 3.78e-02 80 chr7:131010374-131010454 5.59e-04 45_[+2(9.96e-05)]_27 chr17:25435103-25435183 2.95e-03 69_[+1(1.35e-05)]_3 chr2:68834053-68834133 7.37e-04 30_[+1(2.81e-05)]_3_[+3(1.57e-05)]_\ 31 chr15:34948362-34948442 5.03e-02 56_[+2(3.38e-05)]_16 chr11:67044750-67044830 7.30e-02 80 chr8:29995073-29995153 4.85e-01 80 chr7:29834709-29834789 5.16e-04 68_[+1(1.35e-05)]_4 chr8:62791539-62791619 1.85e-01 80 chr8:41668916-41668996 3.60e-02 80 chr6:43608026-43608106 9.50e-02 62_[+5(9.11e-05)]_10 chr1:156151307-156151387 5.73e-02 6_[+2(1.62e-05)]_66 chr7:156716298-156716378 4.44e-01 80 chr4:128551488-128551568 2.23e-06 23_[+4(1.47e-05)]_7_[+1(1.35e-05)]_\ 3_[+3(1.57e-05)]_23 chr2:158103719-158103799 7.43e-01 80 chr6:16236387-16236467 6.39e-04 61_[+1(1.35e-05)]_11 chr3:44479429-44479509 4.80e-07 24_[+4(1.47e-05)]_7_[+1(2.81e-05)]_\ 3_[+3(1.57e-05)]_22 chr19:47848381-47848461 2.15e-05 12_[+4(4.51e-05)]_7_[+1(1.35e-05)]_\ 3_[+3(1.57e-05)]_34 chr5:36442466-36442546 9.26e-01 80 chr19:35411143-35411223 2.62e-03 2_[+2(1.62e-05)]_70 chr7:511335-511415 6.30e-03 57_[+4(8.77e-05)]_15 chr7:139615672-139615752 1.48e-01 25_[+3(6.22e-05)]_47 chr15:66026093-66026173 6.36e-01 80 chr6:27027995-27028075 3.26e-01 80 chr6:37396509-37396589 4.07e-03 46_[+2(1.62e-05)]_18_[+3(6.22e-05)] chr4:129607267-129607347 1.46e-02 60_[+2(5.16e-05)]_12 chr3:186728433-186728513 4.45e-03 48_[+4(4.51e-05)]_24 chr8:130091148-130091228 8.49e-01 80 chr15:89463541-89463621 2.06e-01 80 chr2:208657258-208657338 3.06e-01 80 chr3:14272378-14272458 8.83e-02 80 chr8:123842235-123842315 1.17e-02 9_[+2(3.38e-05)]_63 chr2:120096531-120096611 1.07e-02 18_[+1(1.35e-05)]_54 chr6:20273188-20273268 9.61e-06 14_[+4(1.47e-05)]_7_[+1(1.35e-05)]_\ 3_[+3(1.57e-05)]_32 chr13:23388677-23388757 1.02e-03 8_[+1(2.81e-05)]_29_[+5(3.15e-05)]_\ 27 chr1:167729090-167729170 1.99e-01 80 chr1:12512384-12512464 1.23e-01 80 chr12:109085122-10908520 9.03e-02 24_[+2(8.24e-05)]_48 chr19:49385479-49385559 7.48e-04 [+3(3.05e-05)]_17_[+2(3.38e-05)]_13_\ [+2(1.62e-05)]_13_[+2(1.62e-05)]_5 chr1:160511540-160511620 3.35e-02 80 chr2:69961302-69961382 2.26e-01 80 chr16:17176445-17176525 1.31e-03 8_[+1(1.35e-05)]_3_[+3(1.57e-05)]_\ 53 chr9:100721172-100721252 2.20e-02 80 chr6:28454880-28454960 5.57e-01 80 chr2:169521327-169521407 3.84e-03 66_[+4(4.51e-05)]_6 chr3:13036961-13037041 7.69e-01 80 chr5:139090143-139090223 9.12e-02 80 chr15:64188474-64188554 1.08e-01 80 chr11:44552540-44552620 8.95e-01 80 chr18:9803962-9804042 2.84e-01 80 chr18:3653996-3654076 2.56e-02 38_[+4(1.47e-05)]_34 chr2:178029976-178030056 7.45e-01 80 chr17:75084065-75084145 6.29e-04 14_[+1(1.35e-05)]_3_[+3(1.57e-05)]_\ 47 chr11:57679136-57679216 3.44e-06 13_[+4(4.51e-05)]_7_[+1(1.35e-05)]_\ 3_[+3(3.05e-05)]_33 chr15:35286197-35286277 2.34e-02 29_[+1(1.35e-05)]_43 chr15:96100619-96100699 5.81e-01 80 chr3:5124092-5124172 4.19e-01 80 chr10:104215014-10421509 8.15e-04 4_[+1(2.81e-05)]_29_[+5(3.15e-05)]_\ 31 chr4:144283986-144284066 2.26e-07 39_[+4(1.47e-05)]_6_[+1(1.35e-05)]_\ 3_[+3(1.57e-05)]_8 chr8:29952248-29952328 5.26e-02 8_[+1(2.81e-05)]_64 chr8:37929478-37929558 1.80e-02 42_[+1(2.81e-05)]_30 chr15:35992647-35992727 1.29e-04 12_[+1(1.35e-05)]_11_[+3(1.57e-05)]_\ 41 chr6:3209979-3210059 8.17e-01 80 chr10:27530523-27530603 1.11e-01 80 chr1:46989691-46989771 1.34e-01 70_[+4(8.77e-05)]_2 chr3:5037110-5037190 3.76e-01 80 chr1:27012720-27012800 5.96e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n07.farnam.hpc.yale.internal ********************************************************************************