******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/RCOR1.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr1:16939193-16939273 1.0000 80 chr21:47012866-47012946 1.0000 80 chr11:61876570-61876650 1.0000 80 chr1:154077028-154077108 1.0000 80 chr3:10187507-10187587 1.0000 80 chr11:96037301-96037381 1.0000 80 chr2:192713665-192713745 1.0000 80 chr17:42084521-42084601 1.0000 80 chr1:183614727-183614807 1.0000 80 chr16:67523140-67523220 1.0000 80 chr6:142433761-142433841 1.0000 80 chr6:30910542-30910622 1.0000 80 chr1:181687340-181687420 1.0000 80 chr20:37499534-37499614 1.0000 80 chr2:152991620-152991700 1.0000 80 chr1:245498303-245498383 1.0000 80 chr13:41255654-41255734 1.0000 80 chr1:19986450-19986530 1.0000 80 chr13:111064704-11106478 1.0000 80 chr12:95494179-95494259 1.0000 80 chr12:794734-794814 1.0000 80 chr20:37089036-37089116 1.0000 80 chr12:123002498-12300257 1.0000 80 chr16:69830557-69830637 1.0000 80 chr1:155829353-155829433 1.0000 80 chr11:85753137-85753217 1.0000 80 chr7:30280120-30280200 1.0000 80 chr10:1096216-1096296 1.0000 80 chr1:20848907-20848987 1.0000 80 chr12:1281005-1281085 1.0000 80 chr6:161827806-161827886 1.0000 80 chr12:10902913-10902993 1.0000 80 chr17:35425199-35425279 1.0000 80 chr1:113216380-113216460 1.0000 80 chr2:148602382-148602462 1.0000 80 chr16:66524744-66524824 1.0000 80 chr12:109217688-10921776 1.0000 80 chr7:84459193-84459273 1.0000 80 chr7:45129125-45129205 1.0000 80 chr7:107821687-107821767 1.0000 80 chr5:159546921-159547001 1.0000 80 chr1:200975753-200975833 1.0000 80 chr2:111920517-111920597 1.0000 80 chr1:9844762-9844842 1.0000 80 chr12:4430055-4430135 1.0000 80 chr6:136572716-136572796 1.0000 80 chrX:117858993-117859073 1.0000 80 chr17:62530075-62530155 1.0000 80 chr5:173043063-173043143 1.0000 80 chr22:22062064-22062144 1.0000 80 chr9:132806080-132806160 1.0000 80 chr1:116901797-116901877 1.0000 80 chr7:45027729-45027809 1.0000 80 chr10:45454756-45454836 1.0000 80 chr19:40724246-40724326 1.0000 80 chr18:755701-755781 1.0000 80 chr3:71257578-71257658 1.0000 80 chr2:27201310-27201390 1.0000 80 chr4:128454696-128454776 1.0000 80 chr18:12893949-12894029 1.0000 80 chr11:72526302-72526382 1.0000 80 chr19:1470688-1470768 1.0000 80 chr19:49141539-49141619 1.0000 80 chr22:21211785-21211865 1.0000 80 chr1:228352372-228352452 1.0000 80 chr12:96883271-96883351 1.0000 80 chr4:164101388-164101468 1.0000 80 chr4:40623775-40623855 1.0000 80 chr9:130955305-130955385 1.0000 80 chr9:135853998-135854078 1.0000 80 chr1:150228465-150228545 1.0000 80 chr5:138524369-138524449 1.0000 80 chr19:5971927-5972007 1.0000 80 chr14:21151546-21151626 1.0000 80 chr18:33012810-33012890 1.0000 80 chr4:48700503-48700583 1.0000 80 chr6:159238407-159238487 1.0000 80 chr4:108913509-108913589 1.0000 80 chr4:39559999-39560079 1.0000 80 chr1:211854310-211854390 1.0000 80 chr4:153494082-153494162 1.0000 80 chr7:124702207-124702287 1.0000 80 chr5:86447516-86447596 1.0000 80 chr5:173311843-173311923 1.0000 80 chr8:61705477-61705557 1.0000 80 chr20:48767722-48767802 1.0000 80 chr2:190953769-190953849 1.0000 80 chr8:3009710-3009790 1.0000 80 chr13:96137559-96137639 1.0000 80 chr20:47654662-47654742 1.0000 80 chr5:180131520-180131600 1.0000 80 chr19:54605729-54605809 1.0000 80 chr19:2974585-2974665 1.0000 80 chr5:95997598-95997678 1.0000 80 chr7:97847741-97847821 1.0000 80 chr8:23849085-23849165 1.0000 80 chr7:102624240-102624320 1.0000 80 chr1:231108799-231108879 1.0000 80 chr7:129425001-129425081 1.0000 80 chr12:117627564-11762764 1.0000 80 chr12:31910156-31910236 1.0000 80 chr1:211787495-211787575 1.0000 80 chr11:74919679-74919759 1.0000 80 chr15:72524647-72524727 1.0000 80 chr9:132641517-132641597 1.0000 80 chr9:116160589-116160669 1.0000 80 chr17:41481369-41481449 1.0000 80 chr12:133712484-13371256 1.0000 80 chr7:30978505-30978585 1.0000 80 chr19:29176861-29176941 1.0000 80 chr3:194295764-194295844 1.0000 80 chr2:42876785-42876865 1.0000 80 chr22:21221903-21221983 1.0000 80 chr8:126935427-126935507 1.0000 80 chr22:21974461-21974541 1.0000 80 chr1:8940335-8940415 1.0000 80 chr22:21984411-21984491 1.0000 80 chr3:185823410-185823490 1.0000 80 chr11:118444100-11844418 1.0000 80 chr17:74449353-74449433 1.0000 80 chr17:46949178-46949258 1.0000 80 chr1:45301722-45301802 1.0000 80 chr16:21623536-21623616 1.0000 80 chr11:44564036-44564116 1.0000 80 chr1:65744884-65744964 1.0000 80 chr18:67704087-67704167 1.0000 80 chr12:52311684-52311764 1.0000 80 chr6:36989691-36989771 1.0000 80 chr1:233845962-233846042 1.0000 80 chr12:7394167-7394247 1.0000 80 chr1:9679089-9679169 1.0000 80 chr4:48782195-48782275 1.0000 80 chr1:27372548-27372628 1.0000 80 chr1:116963154-116963234 1.0000 80 chr15:40882085-40882165 1.0000 80 chr9:114364089-114364169 1.0000 80 chr7:30510001-30510081 1.0000 80 chr6:143419345-143419425 1.0000 80 chr7:99160692-99160772 1.0000 80 chr19:9945338-9945418 1.0000 80 chr5:176884783-176884863 1.0000 80 chr18:11981081-11981161 1.0000 80 chr9:102864032-102864112 1.0000 80 chr1:244462779-244462859 1.0000 80 chr11:47536983-47537063 1.0000 80 chr7:137671309-137671389 1.0000 80 chr3:24347400-24347480 1.0000 80 chr1:14769753-14769833 1.0000 80 chr6:25974301-25974381 1.0000 80 chr9:96830707-96830787 1.0000 80 chr14:77506836-77506916 1.0000 80 chr6:30956366-30956446 1.0000 80 chr1:205218328-205218408 1.0000 80 chr16:30560855-30560935 1.0000 80 chr17:74351110-74351190 1.0000 80 chr5:172192439-172192519 1.0000 80 chr11:73727494-73727574 1.0000 80 chr10:73078779-73078859 1.0000 80 chr13:50735394-50735474 1.0000 80 chrX:118611854-118611934 1.0000 80 chr6:138131776-138131856 1.0000 80 chr7:2204977-2205057 1.0000 80 chr10:17658482-17658562 1.0000 80 chr13:114035508-11403558 1.0000 80 chr22:20827622-20827702 1.0000 80 chr22:21132137-21132217 1.0000 80 chr1:52432307-52432387 1.0000 80 chr17:29854768-29854848 1.0000 80 chr7:150484796-150484876 1.0000 80 chr11:85960525-85960605 1.0000 80 chr16:14579281-14579361 1.0000 80 chr2:85814850-85814930 1.0000 80 chr17:25615938-25616018 1.0000 80 chr5:67599740-67599820 1.0000 80 chr4:99722500-99722580 1.0000 80 chr8:142046293-142046373 1.0000 80 chr15:55611920-55612000 1.0000 80 chr2:220341165-220341245 1.0000 80 chr20:42305840-42305920 1.0000 80 chr1:169162852-169162932 1.0000 80 chr6:170863022-170863102 1.0000 80 chr16:50105152-50105232 1.0000 80 chr3:17988324-17988404 1.0000 80 chr4:80120226-80120306 1.0000 80 chr18:60829169-60829249 1.0000 80 chr19:56213855-56213935 1.0000 80 chr15:34949852-34949932 1.0000 80 chr2:178130742-178130822 1.0000 80 chr16:75543463-75543543 1.0000 80 chr5:10620619-10620699 1.0000 80 chr5:134509464-134509544 1.0000 80 chr14:22966910-22966990 1.0000 80 chr19:14116340-14116420 1.0000 80 chr7:86849068-86849148 1.0000 80 chr17:38296192-38296272 1.0000 80 chr7:134278866-134278946 1.0000 80 chr20:30538187-30538267 1.0000 80 chr19:13828318-13828398 1.0000 80 chr11:12863893-12863973 1.0000 80 chr9:135870003-135870083 1.0000 80 chr4:170547178-170547258 1.0000 80 chr7:99766166-99766246 1.0000 80 chr1:203648525-203648605 1.0000 80 chr9:123697894-123697974 1.0000 80 chr19:18668366-18668446 1.0000 80 chr19:3035953-3036033 1.0000 80 chr2:42149455-42149535 1.0000 80 chr9:123659579-123659659 1.0000 80 chr2:47432781-47432861 1.0000 80 chr20:20391522-20391602 1.0000 80 chr1:87230913-87230993 1.0000 80 chr8:61488610-61488690 1.0000 80 chr6:111872767-111872847 1.0000 80 chr19:39872653-39872733 1.0000 80 chr7:50626230-50626310 1.0000 80 chr1:151960973-151961053 1.0000 80 chr6:159241522-159241602 1.0000 80 chr1:109757553-109757633 1.0000 80 chr1:223866743-223866823 1.0000 80 chr2:169853646-169853726 1.0000 80 chr16:2844614-2844694 1.0000 80 chr20:57607748-57607828 1.0000 80 chr22:40895301-40895381 1.0000 80 chr6:106968868-106968948 1.0000 80 chr15:43577890-43577970 1.0000 80 chr3:8899695-8899775 1.0000 80 chr1:109723911-109723991 1.0000 80 chr20:49330333-49330413 1.0000 80 chr1:145059132-145059212 1.0000 80 chr3:39195398-39195478 1.0000 80 chr20:32278034-32278114 1.0000 80 chr9:34989523-34989603 1.0000 80 chr1:90289328-90289408 1.0000 80 chr2:32946568-32946648 1.0000 80 chr22:22302163-22302243 1.0000 80 chr1:6577715-6577795 1.0000 80 chr7:107135400-107135480 1.0000 80 chr22:22146170-22146250 1.0000 80 chr1:20524106-20524186 1.0000 80 chr19:13694057-13694137 1.0000 80 chr15:48847477-48847557 1.0000 80 chr3:124491300-124491380 1.0000 80 chr17:67062813-67062893 1.0000 80 chr18:33039014-33039094 1.0000 80 chr17:40903157-40903237 1.0000 80 chr6:44649728-44649808 1.0000 80 chr13:47695664-47695744 1.0000 80 chr6:167356431-167356511 1.0000 80 chr3:170874355-170874435 1.0000 80 chr6:14039415-14039495 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_RCOR1/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/RCOR1.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.261 C 0.246 G 0.241 T 0.252 Background letter frequencies (from file dataset with add-one prior applied): A 0.261 C 0.246 G 0.241 T 0.252 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF CWSTGATT MEME-1 width = 8 sites = 114 llr = 793 E-value = 6.6e-037 ******************************************************************************** -------------------------------------------------------------------------------- Motif CWSTGATT MEME-1 Description -------------------------------------------------------------------------------- Simplified A :3:3:6:: pos.-specific C a13::11: probability G ::6:a2:: matrix T :617:19a bits 2.1 * * 1.8 * * * 1.6 * * * 1.4 * * ** Relative 1.2 * * ** Entropy 1.0 * ** ** (10.0 bits) 0.8 * *** ** 0.6 ***** ** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CTGTGATT consensus ACA G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWSTGATT MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:47432781-47432861 7 1.50e-05 CGTGGG CTGTGATT TTCTCCAGCA chr1:9679089-9679169 36 1.50e-05 taaatctgcg ctgtgatt gcctcatgac chr22:21974461-21974541 61 1.50e-05 ctgcagtgag ctgtgatt gcaccactgt chr8:126935427-126935507 64 1.50e-05 CCCTGAGGCT CTGTGATT TGTGTGGCT chr7:124702207-124702287 19 1.50e-05 AGATTGATTT CTGTGATT CATTTGTCAC chr1:228352372-228352452 1 1.50e-05 . CTGTGATT GTGTCTCATC chr12:109217688-10921776 22 1.50e-05 tcctggagtg ctgtgatt acaggcgtga chr12:794734-794814 35 1.50e-05 AGAGGCATGT CTGTGATT GTGAGATCTG chr1:245498303-245498383 17 1.50e-05 TCCGCTGGGG CTGTGATT TCAGTTATCT chr3:10187507-10187587 56 1.50e-05 GCAGGGTTTG CTGTGATT TGTAATCACG chr15:48847477-48847557 25 3.04e-05 GCTTCTAACG CTCTGATT CACCTCCGCA chr20:49330333-49330413 41 3.04e-05 CTTTCTCTGT CTCTGATT CCCCACTTGC chr4:48782195-48782275 47 3.04e-05 CTCCCTCCGA CTCTGATT TTAACCGGAT chr5:86447516-86447596 34 3.04e-05 CCAACAGTAG CTCTGATT TACATTAAGT chr2:27201310-27201390 38 3.04e-05 TTACCTGGGA CTCTGATT TGGTCCTTGA chr10:45454756-45454836 28 4.60e-05 CAAGTGCCTG CAGTGATT GCAGCGCCTG chr2:148602382-148602462 26 4.60e-05 GCGGAGCTGA CAGTGATT TTGACAGTGA chr20:37499534-37499614 31 4.60e-05 GTAATTCCTG CAGTGATT CACACCCAGT chr21:47012866-47012946 43 4.60e-05 acaaatctga cagtgatt taaagataac chr6:44649728-44649808 46 7.54e-05 CCGGGTCACC CTGTGGTT TGCTGAAGGT chr1:169162852-169162932 44 7.54e-05 CTGCAGCCTC CTGAGATT TTGAAATGCT chr8:142046293-142046373 64 7.54e-05 AGCACTTTCG CTGAGATT GCTTCCCCT chr11:85960525-85960605 30 7.54e-05 GAATCCTCTT CTGAGATT AGAGAGCTGA chr17:29854768-29854848 64 7.54e-05 TTCCAGGTTT CTGAGATT TGTCTTTCT chr16:30560855-30560935 25 7.54e-05 CAGCAAAGTg ctgagatt acaggcatga chr9:96830707-96830787 33 7.54e-05 catgataaga ctgagatt atgcattttt chr6:36989691-36989771 39 7.54e-05 gggaggatat ctgtggtt tgagttcaga chr9:132641517-132641597 7 7.54e-05 cttgtc ctgtggtt gccgaggcta chr19:2974585-2974665 46 7.54e-05 ACAGGAGCCA CTGAGATT ACAAGATTAG chr5:180131520-180131600 37 7.54e-05 ACTGATTAGG CTGAGATT CTTTCTGTAA chr18:33012810-33012890 37 7.54e-05 TCCTTAGCTA CTGTGGTT TTGCACTGAT chr11:72526302-72526382 11 7.54e-05 GATTGTATGT CTGTGGTT GGAAGTCTAA chr5:173043063-173043143 28 7.54e-05 GACCTCACCG CTGAGATT TCTAAGCTAT chr2:111920517-111920597 10 7.54e-05 AATCACAGA CTGTGGTT ACAGAGTGCC chr11:85753137-85753217 66 7.54e-05 ATTCTTAAAT CTGAGATT GTTTAGG chr2:152991620-152991700 46 7.54e-05 CGCTTTGCCT CTGTGGTT CACTGATGAA chr6:30910542-30910622 45 7.54e-05 CACAGTCGCT CTGAGATT TGCTTCAGGG chr4:170547178-170547258 51 8.96e-05 ttgattttgc ctgtgctt ctgataacac chr6:170863022-170863102 20 1.06e-04 actgctcagg cactgatt ctgtcaatct chr12:52311684-52311764 25 1.06e-04 TCAGCCCCGG CACTGATT AAAGGCCCAT chr8:61705477-61705557 1 1.06e-04 . CACTGATT TGATAAAAGA chr4:48700503-48700583 72 1.06e-04 GTGAGATTTA CACTGATT G chr11:96037301-96037381 57 1.06e-04 GAGGAGGGGA CACTGATT CTACTGCTGA chr4:99722500-99722580 30 1.66e-04 ACTGCTGTGT CAGAGATT ACAAACAGTG chr7:137671309-137671389 64 1.66e-04 CTGCCTTTTC CAGTGGTT GAGCAATCT chr5:176884783-176884863 73 1.66e-04 ATGATTCCAT CAGTGGTT chr1:65744884-65744964 27 1.66e-04 TGGTGGCGTG CAGAGATT GAACCCAGCT chr4:108913509-108913589 39 1.66e-04 CAATGCTTTG CAGTGGTT TAGCTTATCT chr11:61876570-61876650 51 1.66e-04 acaGATTTTG CAGAGATT TATCCCTCAA chr3:170874355-170874435 8 2.26e-04 CTAGAGG CTTTGATT TATCTGGCAG chr17:40903157-40903237 40 2.26e-04 TCCCCTGTTT CTGTGACT TCCCCTTCTC chr22:20827622-20827702 47 2.26e-04 gctgggagtc ccgtgatt gtgtgatcag chr2:42876785-42876865 24 2.26e-04 aagtgccttc ctttgatt taagcagtgg chr20:47654662-47654742 23 2.26e-04 taggtttttg CTGAGGTT AACCTCTTAT chr8:3009710-3009790 49 2.26e-04 GCTACTGTAT CTGAGGTT TGACTACAAA chr4:40623775-40623855 38 2.26e-04 AAAGAGGAGG CTTTGATT TGGAAACAGG chr1:9844762-9844842 65 2.26e-04 AGTTCTCAGG CTTTGATT TTAAAATC chr1:113216380-113216460 56 2.26e-04 ACAACACTAG CTTTGATT TATTTGAAAG chr16:67523140-67523220 70 2.26e-04 gtgcctgtag ctttgatt ttt chr17:25615938-25616018 39 2.40e-04 tcactgcaat ctctgctt actgcaatct chr17:74351110-74351190 73 2.40e-04 CCTTTAGAGA CTCTGCTT chr1:203648525-203648605 31 2.69e-04 TTGACCTACT CTGTGTTT CTCTAGATAA chr19:56213855-56213935 54 2.69e-04 agttgcttat ctgtgttt tacagcctga chr12:96883271-96883351 18 2.69e-04 CCAGGGGCCG CTGTGTTT CTCGGAATGC chr18:60829169-60829249 70 3.15e-04 GTTCTTAGAA CACAGATT CCC chr1:154077028-154077108 36 3.15e-04 cccccaggtg cacagatt tggagctcag chr22:40895301-40895381 16 3.60e-04 TGTTCTGATT CTCTGACT AATACTGAGT chr1:45301722-45301802 44 3.60e-04 ttctaacaga ccctgatt tccgtggccg chr9:116160589-116160669 25 3.60e-04 ggtctaatct ctctgact cACTTCCCAC chr13:96137559-96137639 71 3.60e-04 agcctctgta ccctgatt tt chr1:116901797-116901877 31 3.60e-04 ttttctgtac ctctgact ctgagccagg chr7:84459193-84459273 51 3.60e-04 AGGAACAGCT CCCTGATT AGAGCACTAG chr19:3035953-3036033 52 4.06e-04 GCTggcggag cagaggtt gcatctttct chr2:192713665-192713745 34 4.06e-04 CCTGATTTTG CATTGATT TGCGCTGATT chr7:102624240-102624320 60 4.94e-04 aatctcagcc ctgtggct aaaggagata chr17:35425199-35425279 30 4.94e-04 TGGGCCAGGG CTGTGGCT TGAAATCAGA chr7:30280120-30280200 31 4.94e-04 CCACATTGTG CCGAGATT CATGGTTTGC chr13:41255654-41255734 41 4.94e-04 CAGATAACCT CTGTGGCT TCCTCCAGGC chr16:75543463-75543543 63 5.24e-04 CTGTGATAAG CACTGCTT TTTGCAGTAA chr4:128454696-128454776 56 5.24e-04 CAAATAAAAT CTCTGTTT CACAGCAGCT chr12:95494179-95494259 2 5.24e-04 T CACTGCTT ATCACTAAGC chr12:133712484-13371256 23 5.54e-04 TCTCCGTAAC CTCAGCTT ATCTTTTGTC chr16:66524744-66524824 1 5.54e-04 . CTCAGCTT TTCAGAGTGA chr16:2844614-2844694 13 5.84e-04 gtcatgtggc cagagctt acaagatttg chr2:178130742-178130822 68 5.84e-04 CAAAAAGCTG CAGAGCTT ACTTT chr12:7394167-7394247 28 5.84e-04 CATCCTGACT CAGAGCTT GTTGACCACA chr16:21623536-21623616 64 5.84e-04 GAGAGGCCAG CAGAGCTT TCTAAATCT chr20:32278034-32278114 41 6.42e-04 tcttgaagag ctttgctt gcctcatctg chr1:109757553-109757633 49 6.42e-04 TGTCAAGTAC TTGTGATT TGATTTGTCT chr14:77506836-77506916 26 6.42e-04 TGCAGATTTG CTGTGCCT GTGCGCAGAA chr13:111064704-11106478 25 6.42e-04 GCTTGCAAAT CTGTGCCT CCAGCCAAGG chr3:17988324-17988404 55 6.73e-04 CCCTGGCTTG CACAGGTT GTTATCTATT chr5:134509464-134509544 3 7.32e-04 CT CTCTGGCT GGCCTGGATT chr7:150484796-150484876 53 7.32e-04 CTTAAGTGGC CCCAGATT TCCAAGTATT chr1:181687340-181687420 10 7.32e-04 GTTGATATG CCCTGGTT TTAGATAAGC chr9:123697894-123697974 35 7.94e-04 TATCAGGAAG CAGAGACT GTGGCAGGCA chr16:50105152-50105232 11 7.94e-04 GCAGCAATTA CAGTGGCT GACCTAAAAG chr6:143419345-143419425 59 7.94e-04 tcaacacata cagtggct aattctgatt chr17:38296192-38296272 48 8.97e-04 TTAAGATTTA CCTTGATT CGTGATTTTA chr14:22966910-22966990 1 8.97e-04 . CACTGTTT TTCAAAGGTC chr20:48767722-48767802 52 8.97e-04 AGATAAAGGG CCTTGATT GCAGATTTGG chr19:54605729-54605809 43 9.28e-04 ttctcccggg ctcagttt cttcgtctgt chr6:14039415-14039495 1 9.87e-04 . TTCTGATT GGTGATTCTT chr5:173311843-173311923 67 9.87e-04 GATATTAATG CCCTGCTT CCTGGA chr8:23849085-23849165 58 1.08e-03 AGCTCTAACC CTGTGTCT GCTTTGATAA chr7:107821687-107821767 66 1.08e-03 AATATGAAAT CAGTGCCT CTCAAGA chr11:12863893-12863973 28 1.15e-03 AAACAGGAAG TTGAGATT TGAGGAGAAA chr6:25974301-25974381 11 1.15e-03 atctcaattt ttgtggtt caggaatctg chr1:200975753-200975833 15 1.15e-03 ATTTGACCTC TTGTGGTT CACCCTATGG chr6:142433761-142433841 67 1.18e-03 AGTTAAAAAT CACTGGCT GAAAAT chr6:167356431-167356511 59 1.27e-03 AGACAGCAAT CAGAGGCT GGGACTTACC chr19:13694057-13694137 37 1.39e-03 GTCTGCAAAT CCTAGATT TAGAGGTCAG chr7:97847741-97847821 65 1.39e-03 ccaaaagact cctagatt tgacatat chr12:123002498-12300257 7 1.39e-03 AAACCA CACAGTTT AACAATATGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWSTGATT MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:47432781-47432861 1.5e-05 6_[+1]_66 chr1:9679089-9679169 1.5e-05 35_[+1]_37 chr22:21974461-21974541 1.5e-05 60_[+1]_12 chr8:126935427-126935507 1.5e-05 63_[+1]_9 chr7:124702207-124702287 1.5e-05 18_[+1]_54 chr1:228352372-228352452 1.5e-05 [+1]_72 chr12:109217688-10921776 1.5e-05 21_[+1]_51 chr12:794734-794814 1.5e-05 34_[+1]_38 chr1:245498303-245498383 1.5e-05 16_[+1]_56 chr3:10187507-10187587 1.5e-05 55_[+1]_17 chr15:48847477-48847557 3e-05 24_[+1]_48 chr20:49330333-49330413 3e-05 40_[+1]_32 chr4:48782195-48782275 3e-05 46_[+1]_26 chr5:86447516-86447596 3e-05 33_[+1]_39 chr2:27201310-27201390 3e-05 37_[+1]_35 chr10:45454756-45454836 4.6e-05 27_[+1]_45 chr2:148602382-148602462 4.6e-05 25_[+1]_47 chr20:37499534-37499614 4.6e-05 30_[+1]_42 chr21:47012866-47012946 4.6e-05 42_[+1]_30 chr6:44649728-44649808 7.5e-05 45_[+1]_27 chr1:169162852-169162932 7.5e-05 43_[+1]_29 chr8:142046293-142046373 7.5e-05 63_[+1]_9 chr11:85960525-85960605 7.5e-05 29_[+1]_43 chr17:29854768-29854848 7.5e-05 63_[+1]_9 chr16:30560855-30560935 7.5e-05 24_[+1]_48 chr9:96830707-96830787 7.5e-05 32_[+1]_40 chr6:36989691-36989771 7.5e-05 38_[+1]_34 chr9:132641517-132641597 7.5e-05 6_[+1]_66 chr19:2974585-2974665 7.5e-05 45_[+1]_27 chr5:180131520-180131600 7.5e-05 36_[+1]_36 chr18:33012810-33012890 7.5e-05 36_[+1]_36 chr11:72526302-72526382 7.5e-05 10_[+1]_62 chr5:173043063-173043143 7.5e-05 27_[+1]_45 chr2:111920517-111920597 7.5e-05 9_[+1]_63 chr11:85753137-85753217 7.5e-05 65_[+1]_7 chr2:152991620-152991700 7.5e-05 45_[+1]_27 chr6:30910542-30910622 7.5e-05 44_[+1]_28 chr4:170547178-170547258 9e-05 50_[+1]_22 chr6:170863022-170863102 0.00011 19_[+1]_53 chr12:52311684-52311764 0.00011 24_[+1]_48 chr8:61705477-61705557 0.00011 [+1]_72 chr4:48700503-48700583 0.00011 71_[+1]_1 chr11:96037301-96037381 0.00011 56_[+1]_16 chr4:99722500-99722580 0.00017 29_[+1]_43 chr7:137671309-137671389 0.00017 63_[+1]_9 chr5:176884783-176884863 0.00017 72_[+1] chr1:65744884-65744964 0.00017 26_[+1]_46 chr4:108913509-108913589 0.00017 38_[+1]_34 chr11:61876570-61876650 0.00017 50_[+1]_22 chr3:170874355-170874435 0.00023 7_[+1]_65 chr17:40903157-40903237 0.00023 39_[+1]_33 chr22:20827622-20827702 0.00023 46_[+1]_26 chr2:42876785-42876865 0.00023 23_[+1]_49 chr20:47654662-47654742 0.00023 22_[+1]_50 chr8:3009710-3009790 0.00023 48_[+1]_24 chr4:40623775-40623855 0.00023 37_[+1]_35 chr1:9844762-9844842 0.00023 64_[+1]_8 chr1:113216380-113216460 0.00023 55_[+1]_17 chr16:67523140-67523220 0.00023 69_[+1]_3 chr17:25615938-25616018 0.00024 38_[+1]_34 chr17:74351110-74351190 0.00024 72_[+1] chr1:203648525-203648605 0.00027 30_[+1]_42 chr19:56213855-56213935 0.00027 53_[+1]_19 chr12:96883271-96883351 0.00027 17_[+1]_55 chr18:60829169-60829249 0.00032 69_[+1]_3 chr1:154077028-154077108 0.00032 35_[+1]_37 chr22:40895301-40895381 0.00036 15_[+1]_57 chr1:45301722-45301802 0.00036 43_[+1]_29 chr9:116160589-116160669 0.00036 24_[+1]_48 chr13:96137559-96137639 0.00036 70_[+1]_2 chr1:116901797-116901877 0.00036 30_[+1]_42 chr7:84459193-84459273 0.00036 50_[+1]_22 chr19:3035953-3036033 0.00041 51_[+1]_21 chr2:192713665-192713745 0.00041 33_[+1]_39 chr7:102624240-102624320 0.00049 59_[+1]_13 chr17:35425199-35425279 0.00049 29_[+1]_43 chr7:30280120-30280200 0.00049 30_[+1]_42 chr13:41255654-41255734 0.00049 40_[+1]_32 chr16:75543463-75543543 0.00052 62_[+1]_10 chr4:128454696-128454776 0.00052 55_[+1]_17 chr12:95494179-95494259 0.00052 1_[+1]_71 chr12:133712484-13371256 0.00055 22_[+1]_50 chr16:66524744-66524824 0.00055 [+1]_72 chr16:2844614-2844694 0.00058 12_[+1]_60 chr2:178130742-178130822 0.00058 67_[+1]_5 chr12:7394167-7394247 0.00058 27_[+1]_45 chr16:21623536-21623616 0.00058 63_[+1]_9 chr20:32278034-32278114 0.00064 40_[+1]_32 chr1:109757553-109757633 0.00064 48_[+1]_24 chr14:77506836-77506916 0.00064 25_[+1]_47 chr13:111064704-11106478 0.00064 24_[+1]_48 chr3:17988324-17988404 0.00067 54_[+1]_18 chr5:134509464-134509544 0.00073 2_[+1]_70 chr7:150484796-150484876 0.00073 52_[+1]_20 chr1:181687340-181687420 0.00073 9_[+1]_63 chr9:123697894-123697974 0.00079 34_[+1]_38 chr16:50105152-50105232 0.00079 10_[+1]_62 chr6:143419345-143419425 0.00079 58_[+1]_14 chr17:38296192-38296272 0.0009 47_[+1]_25 chr14:22966910-22966990 0.0009 [+1]_72 chr20:48767722-48767802 0.0009 51_[+1]_21 chr19:54605729-54605809 0.00093 42_[+1]_30 chr6:14039415-14039495 0.00099 [+1]_72 chr5:173311843-173311923 0.00099 66_[+1]_6 chr8:23849085-23849165 0.0011 57_[+1]_15 chr7:107821687-107821767 0.0011 65_[+1]_7 chr11:12863893-12863973 0.0012 27_[+1]_45 chr6:25974301-25974381 0.0012 10_[+1]_62 chr1:200975753-200975833 0.0012 14_[+1]_58 chr6:142433761-142433841 0.0012 66_[+1]_6 chr6:167356431-167356511 0.0013 58_[+1]_14 chr19:13694057-13694137 0.0014 36_[+1]_36 chr7:97847741-97847821 0.0014 64_[+1]_8 chr12:123002498-12300257 0.0014 6_[+1]_66 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWSTGATT MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CWSTGATT width=8 seqs=114 chr2:47432781-47432861 ( 7) CTGTGATT 1 chr1:9679089-9679169 ( 36) CTGTGATT 1 chr22:21974461-21974541 ( 61) CTGTGATT 1 chr8:126935427-126935507 ( 64) CTGTGATT 1 chr7:124702207-124702287 ( 19) CTGTGATT 1 chr1:228352372-228352452 ( 1) CTGTGATT 1 chr12:109217688-10921776 ( 22) CTGTGATT 1 chr12:794734-794814 ( 35) CTGTGATT 1 chr1:245498303-245498383 ( 17) CTGTGATT 1 chr3:10187507-10187587 ( 56) CTGTGATT 1 chr15:48847477-48847557 ( 25) CTCTGATT 1 chr20:49330333-49330413 ( 41) CTCTGATT 1 chr4:48782195-48782275 ( 47) CTCTGATT 1 chr5:86447516-86447596 ( 34) CTCTGATT 1 chr2:27201310-27201390 ( 38) CTCTGATT 1 chr10:45454756-45454836 ( 28) CAGTGATT 1 chr2:148602382-148602462 ( 26) CAGTGATT 1 chr20:37499534-37499614 ( 31) CAGTGATT 1 chr21:47012866-47012946 ( 43) CAGTGATT 1 chr6:44649728-44649808 ( 46) CTGTGGTT 1 chr1:169162852-169162932 ( 44) CTGAGATT 1 chr8:142046293-142046373 ( 64) CTGAGATT 1 chr11:85960525-85960605 ( 30) CTGAGATT 1 chr17:29854768-29854848 ( 64) CTGAGATT 1 chr16:30560855-30560935 ( 25) CTGAGATT 1 chr9:96830707-96830787 ( 33) CTGAGATT 1 chr6:36989691-36989771 ( 39) CTGTGGTT 1 chr9:132641517-132641597 ( 7) CTGTGGTT 1 chr19:2974585-2974665 ( 46) CTGAGATT 1 chr5:180131520-180131600 ( 37) CTGAGATT 1 chr18:33012810-33012890 ( 37) CTGTGGTT 1 chr11:72526302-72526382 ( 11) CTGTGGTT 1 chr5:173043063-173043143 ( 28) CTGAGATT 1 chr2:111920517-111920597 ( 10) CTGTGGTT 1 chr11:85753137-85753217 ( 66) CTGAGATT 1 chr2:152991620-152991700 ( 46) CTGTGGTT 1 chr6:30910542-30910622 ( 45) CTGAGATT 1 chr4:170547178-170547258 ( 51) CTGTGCTT 1 chr6:170863022-170863102 ( 20) CACTGATT 1 chr12:52311684-52311764 ( 25) CACTGATT 1 chr8:61705477-61705557 ( 1) CACTGATT 1 chr4:48700503-48700583 ( 72) CACTGATT 1 chr11:96037301-96037381 ( 57) CACTGATT 1 chr4:99722500-99722580 ( 30) CAGAGATT 1 chr7:137671309-137671389 ( 64) CAGTGGTT 1 chr5:176884783-176884863 ( 73) CAGTGGTT 1 chr1:65744884-65744964 ( 27) CAGAGATT 1 chr4:108913509-108913589 ( 39) CAGTGGTT 1 chr11:61876570-61876650 ( 51) CAGAGATT 1 chr3:170874355-170874435 ( 8) CTTTGATT 1 chr17:40903157-40903237 ( 40) CTGTGACT 1 chr22:20827622-20827702 ( 47) CCGTGATT 1 chr2:42876785-42876865 ( 24) CTTTGATT 1 chr20:47654662-47654742 ( 23) CTGAGGTT 1 chr8:3009710-3009790 ( 49) CTGAGGTT 1 chr4:40623775-40623855 ( 38) CTTTGATT 1 chr1:9844762-9844842 ( 65) CTTTGATT 1 chr1:113216380-113216460 ( 56) CTTTGATT 1 chr16:67523140-67523220 ( 70) CTTTGATT 1 chr17:25615938-25616018 ( 39) CTCTGCTT 1 chr17:74351110-74351190 ( 73) CTCTGCTT 1 chr1:203648525-203648605 ( 31) CTGTGTTT 1 chr19:56213855-56213935 ( 54) CTGTGTTT 1 chr12:96883271-96883351 ( 18) CTGTGTTT 1 chr18:60829169-60829249 ( 70) CACAGATT 1 chr1:154077028-154077108 ( 36) CACAGATT 1 chr22:40895301-40895381 ( 16) CTCTGACT 1 chr1:45301722-45301802 ( 44) CCCTGATT 1 chr9:116160589-116160669 ( 25) CTCTGACT 1 chr13:96137559-96137639 ( 71) CCCTGATT 1 chr1:116901797-116901877 ( 31) CTCTGACT 1 chr7:84459193-84459273 ( 51) CCCTGATT 1 chr19:3035953-3036033 ( 52) CAGAGGTT 1 chr2:192713665-192713745 ( 34) CATTGATT 1 chr7:102624240-102624320 ( 60) CTGTGGCT 1 chr17:35425199-35425279 ( 30) CTGTGGCT 1 chr7:30280120-30280200 ( 31) CCGAGATT 1 chr13:41255654-41255734 ( 41) CTGTGGCT 1 chr16:75543463-75543543 ( 63) CACTGCTT 1 chr4:128454696-128454776 ( 56) CTCTGTTT 1 chr12:95494179-95494259 ( 2) CACTGCTT 1 chr12:133712484-13371256 ( 23) CTCAGCTT 1 chr16:66524744-66524824 ( 1) CTCAGCTT 1 chr16:2844614-2844694 ( 13) CAGAGCTT 1 chr2:178130742-178130822 ( 68) CAGAGCTT 1 chr12:7394167-7394247 ( 28) CAGAGCTT 1 chr16:21623536-21623616 ( 64) CAGAGCTT 1 chr20:32278034-32278114 ( 41) CTTTGCTT 1 chr1:109757553-109757633 ( 49) TTGTGATT 1 chr14:77506836-77506916 ( 26) CTGTGCCT 1 chr13:111064704-11106478 ( 25) CTGTGCCT 1 chr3:17988324-17988404 ( 55) CACAGGTT 1 chr5:134509464-134509544 ( 3) CTCTGGCT 1 chr7:150484796-150484876 ( 53) CCCAGATT 1 chr1:181687340-181687420 ( 10) CCCTGGTT 1 chr9:123697894-123697974 ( 35) CAGAGACT 1 chr16:50105152-50105232 ( 11) CAGTGGCT 1 chr6:143419345-143419425 ( 59) CAGTGGCT 1 chr17:38296192-38296272 ( 48) CCTTGATT 1 chr14:22966910-22966990 ( 1) CACTGTTT 1 chr20:48767722-48767802 ( 52) CCTTGATT 1 chr19:54605729-54605809 ( 43) CTCAGTTT 1 chr6:14039415-14039495 ( 1) TTCTGATT 1 chr5:173311843-173311923 ( 67) CCCTGCTT 1 chr8:23849085-23849165 ( 58) CTGTGTCT 1 chr7:107821687-107821767 ( 66) CAGTGCCT 1 chr11:12863893-12863973 ( 28) TTGAGATT 1 chr6:25974301-25974381 ( 11) TTGTGGTT 1 chr1:200975753-200975833 ( 15) TTGTGGTT 1 chr6:142433761-142433841 ( 67) CACTGGCT 1 chr6:167356431-167356511 ( 59) CAGAGGCT 1 chr19:13694057-13694137 ( 37) CCTAGATT 1 chr7:97847741-97847821 ( 65) CCTAGATT 1 chr12:123002498-12300257 ( 7) CACAGTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWSTGATT MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.99899 E= 6.6e-037 -1348 196 -1348 -252 19 -122 -1348 125 -1348 32 128 -126 23 -1348 -1348 146 -1348 -1348 205 -1348 113 -81 -14 -184 -1348 -72 -1348 176 -1348 -1348 -1348 199 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWSTGATT MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 114 E= 6.6e-037 0.000000 0.956140 0.000000 0.043860 0.298246 0.105263 0.000000 0.596491 0.000000 0.307018 0.587719 0.105263 0.307018 0.000000 0.000000 0.692982 0.000000 0.000000 1.000000 0.000000 0.570175 0.140351 0.219298 0.070175 0.000000 0.149123 0.000000 0.850877 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWSTGATT MEME-1 regular expression -------------------------------------------------------------------------------- C[TA][GC][TA]G[AG]TT -------------------------------------------------------------------------------- Time 5.04 secs. ******************************************************************************** ******************************************************************************** MOTIF AATCWCWG MEME-2 width = 8 sites = 54 llr = 472 E-value = 1.7e-031 ******************************************************************************** -------------------------------------------------------------------------------- Motif AATCWCWG MEME-2 Description -------------------------------------------------------------------------------- Simplified A aa::5:5: pos.-specific C :::a19:: probability G ::1::1:a matrix T ::9:4:5: bits 2.1 * * 1.8 ** * * 1.6 **** * 1.4 **** * * Relative 1.2 **** * * Entropy 1.0 **** *** (12.6 bits) 0.8 **** *** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AATCACAG consensus T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AATCWCWG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr9:34989523-34989603 12 1.65e-05 GATCCACACC AATCACTG CCTGGAATGT chr17:29854768-29854848 14 1.65e-05 GGAAGCAGAG AATCACTG CAGACTGGCA chr3:194295764-194295844 27 1.65e-05 tggggttgaa aatcactg CGTTATCTCA chr4:153494082-153494162 57 1.65e-05 TCACCTTTTA AATCACTG CCTCTTCCAG chr19:5971927-5972007 32 1.65e-05 agcactgaaa aatcactg ctgtgcaaga chr9:130955305-130955385 9 1.65e-05 CGTCCATA AATCACTG CAGTCATGTG chr19:1470688-1470768 20 1.65e-05 CGAAGCCTGT AATCACTG CAGCCGCCGG chr16:69830557-69830637 67 1.65e-05 TCCGTGTGTA AATCACTG CACCTC chr1:183614727-183614807 62 1.65e-05 AAGGAAAGCT AATCACTG CACTGCAGGA chr1:154077028-154077108 14 1.65e-05 tgcattccac aatcactg cactccccca chr3:124491300-124491380 49 4.94e-05 GCCAAGAGAA AATCACAG ATGCGTTCCT chr15:43577890-43577970 11 4.94e-05 GATAAGAGGA AATCACAG TCAGCAACCA chr6:170863022-170863102 33 4.94e-05 tgattctgtc aatctctg tcaatctccc chr17:25615938-25616018 20 4.94e-05 gcagtgctgc aatctctg ctcactgcaa chr12:7394167-7394247 48 4.94e-05 TGACCACAAA AATCACAG GAGTGTTGAG chr3:185823410-185823490 53 4.94e-05 TCTTTCTGTC AATCACAG GCCGCCCTCT chr9:116160589-116160669 47 4.94e-05 TCCCACAAAC AATCTCTG TTGTTTTCTG chr15:72524647-72524727 24 4.94e-05 CCTGCAGCTG AATCACAG GCCTTCATTC chr2:190953769-190953849 60 4.94e-05 ATTGTGTGCA AATCACAG TTACCCTTTG chr4:39559999-39560079 15 4.94e-05 ttgcctgaaa aatcacag ctgctgcagc chr14:21151546-21151626 21 4.94e-05 TTGTGCAAAA AATCTCTG TATCTTGACG chr2:111920517-111920597 1 4.94e-05 . AATCACAG ACTGTGGTTA chr5:159546921-159547001 4 4.94e-05 AAG AATCTCTG CGCAGAGATC chr12:10902913-10902993 45 4.94e-05 GGTTCCAGTA AATCTCTG CTGCTCTTGT chr1:20848907-20848987 32 4.94e-05 GGCAGCCTAA AATCTCTG GGATTTTCCT chr12:794734-794814 63 4.94e-05 ATTCACAGAA AATCACAG ACTGACAAGC chr17:42084521-42084601 13 4.94e-05 CTTGAATGAA AATCACAG ACAAATCTAT chr1:16939193-16939273 29 4.94e-05 GACGCAGGGA AATCACAG CAACTCTTTG chr6:44649728-44649808 17 6.59e-05 CCTGCTCTCC AATCTCAG TCTTGCGGTT chr7:86849068-86849148 51 6.59e-05 CACTTCCTCA AATCTCAG CCCTTGGCGC chr7:99160692-99160772 46 6.59e-05 GGGCAGCAGA AATCTCAG ATGTTTACCC chr1:27372548-27372628 55 6.59e-05 CTGAGGCAAA AATCTCAG CCGCACGTGG chr16:21623536-21623616 41 6.59e-05 TCTGATGTTG AATCTCAG TGAAAGAGAG chr7:102624240-102624320 50 6.59e-05 gattttcagg aatctcag ccctgtggct chr1:150228465-150228545 46 6.59e-05 TGGAAATCGG AATCTCAG CTCAGCGCTC chr1:116901797-116901877 63 6.59e-05 aatccctctg aatctcag cttcctcatt chr12:123002498-12300257 58 6.59e-05 AGTGGTTAAA AATCTCAg ctgggcagag chr6:142433761-142433841 51 6.59e-05 ACATTTTGTA AATCTCAG TTAAAAATCA chr6:111872767-111872847 60 9.75e-05 AGAATCAGTT AATCCCTG AACTCAAGGA chr4:99722500-99722580 58 9.75e-05 AGGTGCACAT AATCCCTG CGCAGCTATT chr7:137671309-137671389 33 9.75e-05 CTGACCGCAA AATCCCTG CTCCTCCTAC chr11:72526302-72526382 33 9.75e-05 GTCTAACCAC AATCCCTG CGGCTCTCTC chr12:4430055-4430135 27 9.75e-05 AACAACCACA AATCAGTG CGCCGGCTTC chr20:57607748-57607828 44 1.46e-04 GGCTTTTTTA AATCTGTG GACAGACAAG chr17:35425199-35425279 41 1.46e-04 TGTGGCTTGA AATCAGAG CTCTGCTGGG chr20:37089036-37089116 57 1.46e-04 actccgaggg aatcagag ccccagtaac chr3:24347400-24347480 29 1.62e-04 ACTCCCAAGA AATCTGAG TCTATCTCCT chr2:42876785-42876865 60 1.62e-04 gtggtctgaa aatctgag gcactttcca chr18:755701-755781 49 1.62e-04 gagataaaga aatctgag tccttgatga chr19:49141539-49141619 2 1.78e-04 G AAGCACTG GGCTGAACCA chr3:10187507-10187587 4 1.78e-04 GAG AAGCACTG ATTTGAGAAG chr16:50105152-50105232 26 2.09e-04 GCTGACCTAA AAGCACAG ATGTTTCTTA chr4:40623775-40623855 57 2.09e-04 GGAAACAGGG AAGCTCTG AAATGGGGAA chr13:41255654-41255734 17 2.09e-04 ACCAGATTGT AAGCTCTG GCCCTCCAGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AATCWCWG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:34989523-34989603 1.6e-05 11_[+2]_61 chr17:29854768-29854848 1.6e-05 13_[+2]_59 chr3:194295764-194295844 1.6e-05 26_[+2]_46 chr4:153494082-153494162 1.6e-05 56_[+2]_16 chr19:5971927-5972007 1.6e-05 31_[+2]_41 chr9:130955305-130955385 1.6e-05 8_[+2]_64 chr19:1470688-1470768 1.6e-05 19_[+2]_53 chr16:69830557-69830637 1.6e-05 66_[+2]_6 chr1:183614727-183614807 1.6e-05 61_[+2]_11 chr1:154077028-154077108 1.6e-05 13_[+2]_59 chr3:124491300-124491380 4.9e-05 48_[+2]_24 chr15:43577890-43577970 4.9e-05 10_[+2]_62 chr6:170863022-170863102 4.9e-05 32_[+2]_40 chr17:25615938-25616018 4.9e-05 19_[+2]_53 chr12:7394167-7394247 4.9e-05 47_[+2]_25 chr3:185823410-185823490 4.9e-05 52_[+2]_20 chr9:116160589-116160669 4.9e-05 46_[+2]_26 chr15:72524647-72524727 4.9e-05 23_[+2]_49 chr2:190953769-190953849 4.9e-05 59_[+2]_13 chr4:39559999-39560079 4.9e-05 14_[+2]_58 chr14:21151546-21151626 4.9e-05 20_[+2]_52 chr2:111920517-111920597 4.9e-05 [+2]_72 chr5:159546921-159547001 4.9e-05 3_[+2]_69 chr12:10902913-10902993 4.9e-05 44_[+2]_28 chr1:20848907-20848987 4.9e-05 31_[+2]_41 chr12:794734-794814 4.9e-05 62_[+2]_10 chr17:42084521-42084601 4.9e-05 12_[+2]_60 chr1:16939193-16939273 4.9e-05 28_[+2]_44 chr6:44649728-44649808 6.6e-05 16_[+2]_56 chr7:86849068-86849148 6.6e-05 50_[+2]_22 chr7:99160692-99160772 6.6e-05 45_[+2]_27 chr1:27372548-27372628 6.6e-05 54_[+2]_18 chr16:21623536-21623616 6.6e-05 40_[+2]_32 chr7:102624240-102624320 6.6e-05 49_[+2]_23 chr1:150228465-150228545 6.6e-05 45_[+2]_27 chr1:116901797-116901877 6.6e-05 62_[+2]_10 chr12:123002498-12300257 6.6e-05 57_[+2]_15 chr6:142433761-142433841 6.6e-05 50_[+2]_22 chr6:111872767-111872847 9.8e-05 59_[+2]_13 chr4:99722500-99722580 9.8e-05 57_[+2]_15 chr7:137671309-137671389 9.8e-05 32_[+2]_40 chr11:72526302-72526382 9.8e-05 32_[+2]_40 chr12:4430055-4430135 9.8e-05 26_[+2]_46 chr20:57607748-57607828 0.00015 43_[+2]_29 chr17:35425199-35425279 0.00015 40_[+2]_32 chr20:37089036-37089116 0.00015 56_[+2]_16 chr3:24347400-24347480 0.00016 28_[+2]_44 chr2:42876785-42876865 0.00016 59_[+2]_13 chr18:755701-755781 0.00016 48_[+2]_24 chr19:49141539-49141619 0.00018 1_[+2]_71 chr3:10187507-10187587 0.00018 3_[+2]_69 chr16:50105152-50105232 0.00021 25_[+2]_47 chr4:40623775-40623855 0.00021 56_[+2]_16 chr13:41255654-41255734 0.00021 16_[+2]_56 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AATCWCWG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AATCWCWG width=8 seqs=54 chr9:34989523-34989603 ( 12) AATCACTG 1 chr17:29854768-29854848 ( 14) AATCACTG 1 chr3:194295764-194295844 ( 27) AATCACTG 1 chr4:153494082-153494162 ( 57) AATCACTG 1 chr19:5971927-5972007 ( 32) AATCACTG 1 chr9:130955305-130955385 ( 9) AATCACTG 1 chr19:1470688-1470768 ( 20) AATCACTG 1 chr16:69830557-69830637 ( 67) AATCACTG 1 chr1:183614727-183614807 ( 62) AATCACTG 1 chr1:154077028-154077108 ( 14) AATCACTG 1 chr3:124491300-124491380 ( 49) AATCACAG 1 chr15:43577890-43577970 ( 11) AATCACAG 1 chr6:170863022-170863102 ( 33) AATCTCTG 1 chr17:25615938-25616018 ( 20) AATCTCTG 1 chr12:7394167-7394247 ( 48) AATCACAG 1 chr3:185823410-185823490 ( 53) AATCACAG 1 chr9:116160589-116160669 ( 47) AATCTCTG 1 chr15:72524647-72524727 ( 24) AATCACAG 1 chr2:190953769-190953849 ( 60) AATCACAG 1 chr4:39559999-39560079 ( 15) AATCACAG 1 chr14:21151546-21151626 ( 21) AATCTCTG 1 chr2:111920517-111920597 ( 1) AATCACAG 1 chr5:159546921-159547001 ( 4) AATCTCTG 1 chr12:10902913-10902993 ( 45) AATCTCTG 1 chr1:20848907-20848987 ( 32) AATCTCTG 1 chr12:794734-794814 ( 63) AATCACAG 1 chr17:42084521-42084601 ( 13) AATCACAG 1 chr1:16939193-16939273 ( 29) AATCACAG 1 chr6:44649728-44649808 ( 17) AATCTCAG 1 chr7:86849068-86849148 ( 51) AATCTCAG 1 chr7:99160692-99160772 ( 46) AATCTCAG 1 chr1:27372548-27372628 ( 55) AATCTCAG 1 chr16:21623536-21623616 ( 41) AATCTCAG 1 chr7:102624240-102624320 ( 50) AATCTCAG 1 chr1:150228465-150228545 ( 46) AATCTCAG 1 chr1:116901797-116901877 ( 63) AATCTCAG 1 chr12:123002498-12300257 ( 58) AATCTCAG 1 chr6:142433761-142433841 ( 51) AATCTCAG 1 chr6:111872767-111872847 ( 60) AATCCCTG 1 chr4:99722500-99722580 ( 58) AATCCCTG 1 chr7:137671309-137671389 ( 33) AATCCCTG 1 chr11:72526302-72526382 ( 33) AATCCCTG 1 chr12:4430055-4430135 ( 27) AATCAGTG 1 chr20:57607748-57607828 ( 44) AATCTGTG 1 chr17:35425199-35425279 ( 41) AATCAGAG 1 chr20:37089036-37089116 ( 57) AATCAGAG 1 chr3:24347400-24347480 ( 29) AATCTGAG 1 chr2:42876785-42876865 ( 60) AATCTGAG 1 chr18:755701-755781 ( 49) AATCTGAG 1 chr19:49141539-49141619 ( 2) AAGCACTG 1 chr3:10187507-10187587 ( 4) AAGCACTG 1 chr16:50105152-50105232 ( 26) AAGCACAG 1 chr4:40623775-40623855 ( 57) AAGCTCTG 1 chr13:41255654-41255734 ( 17) AAGCTCTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AATCWCWG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.59303 E= 1.7e-031 194 -1240 -1240 -1240 194 -1240 -1240 -1240 -1240 -1240 -138 185 -1240 202 -1240 -1240 94 -173 -1240 76 -1240 182 -90 -1240 94 -1240 -1240 99 -1240 -1240 205 -1240 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AATCWCWG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 54 E= 1.7e-031 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.092593 0.907407 0.000000 1.000000 0.000000 0.000000 0.500000 0.074074 0.000000 0.425926 0.000000 0.870370 0.129630 0.000000 0.500000 0.000000 0.000000 0.500000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AATCWCWG MEME-2 regular expression -------------------------------------------------------------------------------- AATC[AT]C[AT]G -------------------------------------------------------------------------------- Time 8.67 secs. ******************************************************************************** ******************************************************************************** MOTIF SAGATAAR MEME-3 width = 8 sites = 60 llr = 489 E-value = 2.4e-024 ******************************************************************************** -------------------------------------------------------------------------------- Motif SAGATAAR MEME-3 Description -------------------------------------------------------------------------------- Simplified A 28:a:aa3 pos.-specific C 4::::::2 probability G 4:a::::5 matrix T 12::a::: bits 2.1 * * 1.8 ***** 1.6 ***** 1.4 ***** Relative 1.2 ****** Entropy 1.0 ****** (11.8 bits) 0.8 ****** 0.6 ******* 0.4 ******* 0.2 ******** 0.0 -------- Multilevel GAGATAAG consensus CT A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SAGATAAR MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr14:22966910-22966990 50 1.64e-05 GGGAAAGGCA GAGATAAG AAGCAAAGCT chr1:169162852-169162932 11 1.64e-05 GTGTATTACA GAGATAAG GCCTGGCACA chr20:42305840-42305920 42 1.64e-05 CTGGAATGGA GAGATAAG ACCGTGTGCA chr11:85960525-85960605 70 1.64e-05 ACTCGTGTGT GAGATAAG GTA chr6:30956366-30956446 57 1.64e-05 TGACTTGGGA GAGATAAG GAGGGAGGGC chr1:14769753-14769833 31 1.64e-05 TCTGCACCAT GAGATAAG GTGGCTGGCT chr22:21974461-21974541 42 1.64e-05 ttgagcccag gagataag actgcagtga chr7:102624240-102624320 72 1.64e-05 gtggctaaag gagataag a chr22:22062064-22062144 42 1.64e-05 ttagggccag gagataag tagtttaggc chr13:47695664-47695744 40 3.31e-05 ctgggtgtca cagataag gaaactgcag chr19:39872653-39872733 41 3.31e-05 GCTGCAGAGA CAGATAAG GCTCGTCTGG chr15:72524647-72524727 56 3.31e-05 CCTGTTAGCT CAGATAAG CTGGGAGGAG chr4:39559999-39560079 51 3.31e-05 taagcctgga cagataag cagccagtaa chr4:164101388-164101468 35 3.31e-05 ctgtaaaaca cagataag caattcgggc chr7:45027729-45027809 43 3.31e-05 ccctaacaga cagataag gcagaactgt chr10:1096216-1096296 46 3.31e-05 tggcttCACA CAGATAAG AAAATCTGGC chr1:6577715-6577795 72 5.08e-05 CAGGGAGACA GAGATAAA G chr1:109723911-109723991 19 5.08e-05 TGGAGCCCCT GAGATAAA CTTTATCTTC chr19:13828318-13828398 26 5.08e-05 aagttaggaa gagataaa gccccgagga chr5:67599740-67599820 59 5.08e-05 ccttatctgt gagataaa ggtatgggcc chr1:52432307-52432387 39 5.08e-05 AGGCTTTGGG GAGATAAA AGTGTCAGCA chr1:65744884-65744964 62 5.08e-05 CTGCTGCTGT GAGATAAA TGGGAAAATC chr1:8940335-8940415 56 5.08e-05 AATGGTTAGA GAGATAAA GATACTCTGC chr20:48767722-48767802 41 5.08e-05 AGGTCTGGAG GAGATAAA GGGCCTTGAT chr18:755701-755781 39 5.08e-05 ctgcagaata gagataaa gaaatctgag chr1:90289328-90289408 60 6.89e-05 TGTGTGGAAC CAGATAAA AGTTTATGAA chr1:203648525-203648605 42 1.04e-04 TGTGTTTCTC TAGATAAG CCTGAGGCAA chr9:102864032-102864112 68 1.04e-04 ctgctccctt tagataag tacat chr15:40882085-40882165 25 1.04e-04 TCCATCCCTG TAGATAAG AGCATCTTGT chr22:21221903-21221983 63 1.04e-04 CCTCACAGGC AAGATAAG CCACCCTCAC chr3:71257578-71257658 17 1.04e-04 ATCCAAGCAA AAGATAAG AAAAGCAAAC chr1:181687340-181687420 19 1.04e-04 GCCCTGGTTT TAGATAAG CAGCTTGCTC chr8:61488610-61488690 67 1.36e-04 GCTGGAAACA GTGATAAG AGTCTA chr5:134509464-134509544 64 1.36e-04 TGGTCACCAG GTGATAAG TGATTGCCC chr16:75543463-75543543 55 1.36e-04 TGCTGAAGCT GTGATAAG CACTGCTTTT chr20:32278034-32278114 67 1.69e-04 tgcagaacaa cagataac agcttc chr3:8899695-8899775 31 1.69e-04 ctgtcatttg cagataac tactcccctt chr22:40895301-40895381 63 1.69e-04 ACACAGAGCA CTGATAAG CAGTCTGAAC chr7:50626230-50626310 32 1.69e-04 gctcaagctc ctgataag ctcgtggtat chr1:87230913-87230993 4 1.69e-04 GTA CTGATAAG GCTGCCTGGG chr2:47432781-47432861 73 1.69e-04 GAAGAGCTGC CTGATAAG chr9:96830707-96830787 64 1.69e-04 agaagggtca cagataac acaagatgt chr6:25974301-25974381 61 1.69e-04 tgcttagggt ctgataag gctgcagtta chr9:132806080-132806160 68 1.69e-04 GTGGGGTACA CAGATAAC TTGTT chr13:41255654-41255734 31 1.69e-04 TCTGGCCCTC CAGATAAC CTCTGTGGCT chr22:22146170-22146250 52 2.07e-04 aatggggcaa aagataaa aaatcggtga chr22:22302163-22302243 64 2.07e-04 TGGAAGCCTA AAGATAAA AAACACAAA chr2:32946568-32946648 38 2.07e-04 ATCCAAGAGG AAGATAAA TCACAAGCTG chr15:34949852-34949932 27 2.07e-04 gtcagttacc aagataaa gaaagccgag chrX:118611854-118611934 9 2.07e-04 AAAGGTCA AAGATAAA TCCGTCCTGC chr7:84459193-84459273 68 2.24e-04 TAGAGCACTA GTGATAAA TCAAC chr14:77506836-77506916 48 2.42e-04 GCAGAAGGAA CTGATAAA TGCCGTTGCA chr12:1281005-1281085 48 2.42e-04 CTGGGCAGGG CTGATAAA AGCCAAAACA chr6:14039415-14039495 63 3.11e-04 CTGGGCTGCA TTGATAAG GAGCTGGACA chr16:2844614-2844694 52 3.11e-04 attgcttcta tagataac accactattg chr6:111872767-111872847 27 3.11e-04 CTGAACCTTG TAGATAAC AACAGATTGG chr7:150484796-150484876 28 3.11e-04 TCATCAGGAC AAGATAAC GAACAGACTT chr8:23849085-23849165 69 3.11e-04 TGTGTCTGCT TTGATAAG AGCT chr21:47012866-47012946 53 3.11e-04 cagtgattta aagataac acccggtgat chr4:170547178-170547258 59 3.44e-04 gcctgtgctt ctgataac actggctata -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SAGATAAR MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr14:22966910-22966990 1.6e-05 49_[+3]_23 chr1:169162852-169162932 1.6e-05 10_[+3]_62 chr20:42305840-42305920 1.6e-05 41_[+3]_31 chr11:85960525-85960605 1.6e-05 69_[+3]_3 chr6:30956366-30956446 1.6e-05 56_[+3]_16 chr1:14769753-14769833 1.6e-05 30_[+3]_42 chr22:21974461-21974541 1.6e-05 41_[+3]_31 chr7:102624240-102624320 1.6e-05 71_[+3]_1 chr22:22062064-22062144 1.6e-05 41_[+3]_31 chr13:47695664-47695744 3.3e-05 39_[+3]_33 chr19:39872653-39872733 3.3e-05 40_[+3]_32 chr15:72524647-72524727 3.3e-05 55_[+3]_17 chr4:39559999-39560079 3.3e-05 50_[+3]_22 chr4:164101388-164101468 3.3e-05 34_[+3]_38 chr7:45027729-45027809 3.3e-05 42_[+3]_30 chr10:1096216-1096296 3.3e-05 45_[+3]_27 chr1:6577715-6577795 5.1e-05 71_[+3]_1 chr1:109723911-109723991 5.1e-05 18_[+3]_54 chr19:13828318-13828398 5.1e-05 25_[+3]_47 chr5:67599740-67599820 5.1e-05 58_[+3]_14 chr1:52432307-52432387 5.1e-05 38_[+3]_34 chr1:65744884-65744964 5.1e-05 61_[+3]_11 chr1:8940335-8940415 5.1e-05 55_[+3]_17 chr20:48767722-48767802 5.1e-05 40_[+3]_32 chr18:755701-755781 5.1e-05 38_[+3]_34 chr1:90289328-90289408 6.9e-05 59_[+3]_13 chr1:203648525-203648605 0.0001 41_[+3]_31 chr9:102864032-102864112 0.0001 67_[+3]_5 chr15:40882085-40882165 0.0001 24_[+3]_48 chr22:21221903-21221983 0.0001 62_[+3]_10 chr3:71257578-71257658 0.0001 16_[+3]_56 chr1:181687340-181687420 0.0001 18_[+3]_54 chr8:61488610-61488690 0.00014 66_[+3]_6 chr5:134509464-134509544 0.00014 63_[+3]_9 chr16:75543463-75543543 0.00014 54_[+3]_18 chr20:32278034-32278114 0.00017 66_[+3]_6 chr3:8899695-8899775 0.00017 30_[+3]_42 chr22:40895301-40895381 0.00017 62_[+3]_10 chr7:50626230-50626310 0.00017 31_[+3]_41 chr1:87230913-87230993 0.00017 3_[+3]_69 chr2:47432781-47432861 0.00017 72_[+3] chr9:96830707-96830787 0.00017 63_[+3]_9 chr6:25974301-25974381 0.00017 60_[+3]_12 chr9:132806080-132806160 0.00017 67_[+3]_5 chr13:41255654-41255734 0.00017 30_[+3]_42 chr22:22146170-22146250 0.00021 51_[+3]_21 chr22:22302163-22302243 0.00021 63_[+3]_9 chr2:32946568-32946648 0.00021 37_[+3]_35 chr15:34949852-34949932 0.00021 26_[+3]_46 chrX:118611854-118611934 0.00021 8_[+3]_64 chr7:84459193-84459273 0.00022 67_[+3]_5 chr14:77506836-77506916 0.00024 47_[+3]_25 chr12:1281005-1281085 0.00024 47_[+3]_25 chr6:14039415-14039495 0.00031 62_[+3]_10 chr16:2844614-2844694 0.00031 51_[+3]_21 chr6:111872767-111872847 0.00031 26_[+3]_46 chr7:150484796-150484876 0.00031 27_[+3]_45 chr8:23849085-23849165 0.00031 68_[+3]_4 chr21:47012866-47012946 0.00031 52_[+3]_20 chr4:170547178-170547258 0.00034 58_[+3]_14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SAGATAAR MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF SAGATAAR width=8 seqs=60 chr14:22966910-22966990 ( 50) GAGATAAG 1 chr1:169162852-169162932 ( 11) GAGATAAG 1 chr20:42305840-42305920 ( 42) GAGATAAG 1 chr11:85960525-85960605 ( 70) GAGATAAG 1 chr6:30956366-30956446 ( 57) GAGATAAG 1 chr1:14769753-14769833 ( 31) GAGATAAG 1 chr22:21974461-21974541 ( 42) GAGATAAG 1 chr7:102624240-102624320 ( 72) GAGATAAG 1 chr22:22062064-22062144 ( 42) GAGATAAG 1 chr13:47695664-47695744 ( 40) CAGATAAG 1 chr19:39872653-39872733 ( 41) CAGATAAG 1 chr15:72524647-72524727 ( 56) CAGATAAG 1 chr4:39559999-39560079 ( 51) CAGATAAG 1 chr4:164101388-164101468 ( 35) CAGATAAG 1 chr7:45027729-45027809 ( 43) CAGATAAG 1 chr10:1096216-1096296 ( 46) CAGATAAG 1 chr1:6577715-6577795 ( 72) GAGATAAA 1 chr1:109723911-109723991 ( 19) GAGATAAA 1 chr19:13828318-13828398 ( 26) GAGATAAA 1 chr5:67599740-67599820 ( 59) GAGATAAA 1 chr1:52432307-52432387 ( 39) GAGATAAA 1 chr1:65744884-65744964 ( 62) GAGATAAA 1 chr1:8940335-8940415 ( 56) GAGATAAA 1 chr20:48767722-48767802 ( 41) GAGATAAA 1 chr18:755701-755781 ( 39) GAGATAAA 1 chr1:90289328-90289408 ( 60) CAGATAAA 1 chr1:203648525-203648605 ( 42) TAGATAAG 1 chr9:102864032-102864112 ( 68) TAGATAAG 1 chr15:40882085-40882165 ( 25) TAGATAAG 1 chr22:21221903-21221983 ( 63) AAGATAAG 1 chr3:71257578-71257658 ( 17) AAGATAAG 1 chr1:181687340-181687420 ( 19) TAGATAAG 1 chr8:61488610-61488690 ( 67) GTGATAAG 1 chr5:134509464-134509544 ( 64) GTGATAAG 1 chr16:75543463-75543543 ( 55) GTGATAAG 1 chr20:32278034-32278114 ( 67) CAGATAAC 1 chr3:8899695-8899775 ( 31) CAGATAAC 1 chr22:40895301-40895381 ( 63) CTGATAAG 1 chr7:50626230-50626310 ( 32) CTGATAAG 1 chr1:87230913-87230993 ( 4) CTGATAAG 1 chr2:47432781-47432861 ( 73) CTGATAAG 1 chr9:96830707-96830787 ( 64) CAGATAAC 1 chr6:25974301-25974381 ( 61) CTGATAAG 1 chr9:132806080-132806160 ( 68) CAGATAAC 1 chr13:41255654-41255734 ( 31) CAGATAAC 1 chr22:22146170-22146250 ( 52) AAGATAAA 1 chr22:22302163-22302243 ( 64) AAGATAAA 1 chr2:32946568-32946648 ( 38) AAGATAAA 1 chr15:34949852-34949932 ( 27) AAGATAAA 1 chrX:118611854-118611934 ( 9) AAGATAAA 1 chr7:84459193-84459273 ( 68) GTGATAAA 1 chr14:77506836-77506916 ( 48) CTGATAAA 1 chr12:1281005-1281085 ( 48) CTGATAAA 1 chr6:14039415-14039495 ( 63) TTGATAAG 1 chr16:2844614-2844694 ( 52) TAGATAAC 1 chr6:111872767-111872847 ( 27) TAGATAAC 1 chr7:150484796-150484876 ( 28) AAGATAAC 1 chr8:23849085-23849165 ( 69) TTGATAAG 1 chr21:47012866-47012946 ( 53) AAGATAAC 1 chr4:170547178-170547258 ( 59) CTGATAAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SAGATAAR MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.95252 E= 2.4e-024 -80 51 60 -92 155 -1255 -1255 -11 -1255 -1255 205 -1255 194 -1255 -1255 -1255 -1255 -1255 -1255 199 194 -1255 -1255 -1255 194 -1255 -1255 -1255 20 -56 114 -1255 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SAGATAAR MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 60 E= 2.4e-024 0.150000 0.350000 0.366667 0.133333 0.766667 0.000000 0.000000 0.233333 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.300000 0.166667 0.533333 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SAGATAAR MEME-3 regular expression -------------------------------------------------------------------------------- [GC][AT]GATAA[GA] -------------------------------------------------------------------------------- Time 12.24 secs. ******************************************************************************** ******************************************************************************** MOTIF YCTTATCT MEME-4 width = 8 sites = 46 llr = 366 E-value = 1.4e-005 ******************************************************************************** -------------------------------------------------------------------------------- Motif YCTTATCT MEME-4 Description -------------------------------------------------------------------------------- Simplified A ::::9::2 pos.-specific C 561:::a: probability G 22:::::: matrix T 429a1a:8 bits 2.1 * ** 1.8 * ** 1.6 ** ** 1.4 ***** Relative 1.2 ****** Entropy 1.0 ****** (11.5 bits) 0.8 ****** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CCTTATCT consensus TT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCTTATCT MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr5:67599740-67599820 49 1.57e-05 gcctccaact ccttatct gtgagataaa chr11:73727494-73727574 47 1.57e-05 ACCTAGGGGG CCTTATCT GCAAGGCCCA chr5:95997598-95997678 7 1.57e-05 CCGCTT CCTTATCT AGACTGTCCA chr8:3009710-3009790 13 1.57e-05 ATGCATCTTG CCTTATCT TGGCGACTCA chr4:153494082-153494162 32 1.57e-05 GAAAACTCTT CCTTATCT CCATGATTCA chr12:4430055-4430135 44 1.57e-05 GCGCCGGCTT CCTTATCT GCCCCGAACG chr16:67523140-67523220 12 1.57e-05 ggccttgctc ccttatct gtgcagctgc chr20:20391522-20391602 65 3.17e-05 TGCCTCTCCC TCTTATCT CCCAACAA chr11:47536983-47537063 43 3.17e-05 GCCAAATCTG TCTTATCT AGTGAGTCAC chr11:74919679-74919759 32 3.17e-05 GCCAGCCCAG TCTTATCT CTCCCCACAG chr20:47654662-47654742 35 3.17e-05 GAGGTTAACC TCTTATCT CTTGTCCCTC chr1:211854310-211854390 52 3.17e-05 TGTGTATAAG TCTTATCT CCACAATTAC chr22:21211785-21211865 5 3.17e-05 ACTG TCTTATCT TGTCGGAAAA chr1:109723911-109723991 27 6.31e-05 CTGAGATAAA CTTTATCT TCTTACAGTT chr7:134278866-134278946 45 6.31e-05 TTAACTGGGC CTTTATCT ATCTGGCCTA chr16:30560855-30560935 65 6.31e-05 cctgacatgc ctttatct ctctctct chr1:244462779-244462859 3 6.31e-05 GG CTTTATCT AGCAGACAAC chr3:194295764-194295844 35 6.31e-05 aaaatcactg CGTTATCT CACGGTCATA chr17:41481369-41481449 54 6.31e-05 GGAGTGAGAG CTTTATCT CCTAAGCCCA chr16:66524744-66524824 49 6.31e-05 CTGCACATAG CTTTATCT CTTGCTAGCA chr22:21132137-21132217 70 7.85e-05 TGTGCTAAAA GCTTATCT TGT chr1:233845962-233846042 9 7.85e-05 TGATGAGA GCTTATCT CAGGGGCTCA chr4:108913509-108913589 49 7.85e-05 CAGTGGTTTA GCTTATCT GCTTTTGCAC chr6:159241522-159241602 19 1.11e-04 TGTCAGGGCC TGTTATCT CCCACTTGCA chr18:60829169-60829249 31 1.11e-04 GCTGGTTGAG TGTTATCT ATAGATGTGT chr12:31910156-31910236 20 1.11e-04 acagtagtgg tgttatct ataggagcaa chr7:107135400-107135480 19 1.27e-04 CAAATCCCCG CCTTATCA TTAACATACA chr22:22302163-22302243 19 1.27e-04 AGAGGGCTGT CCTTATCA GGAATTGCTA chr6:136572716-136572796 36 1.43e-04 TTTCCCACTC TCTTATCA AACAGCAAAC chr11:96037301-96037381 24 1.43e-04 TTCAAGCCTC TCTTATCA CAGTGTACAG chr4:48700503-48700583 8 1.89e-04 CAAAAGT GGTTATCT TGGTATTGCC chr7:84459193-84459273 31 1.89e-04 AGGCAAGAGA GTTTATCT GAAGGAACAG chr6:106968868-106968948 45 2.20e-04 CAGAACGGTT CCCTATCT CAGTCTTCAG chr5:10620619-10620699 37 2.20e-04 AGAGGGGATT TCTTTTCT TACTGATCTG chr18:67704087-67704167 72 2.20e-04 accacccctc ccctatct a chr1:116901797-116901877 19 2.20e-04 ttgagtgaaa tcttttct gtacctctga chr17:29854768-29854848 35 2.84e-04 ACTGGCAGGC GCTTATCA GATAGTCTAC chr10:17658482-17658562 42 2.84e-04 TCAAGGTCCA GCTTATCA GCCACGGAGC chr8:23849085-23849165 36 2.84e-04 GCTTCCAGCA TCCTATCT CTGCAGCTCT chr1:223866743-223866823 27 3.18e-04 gctgtttcaa tgttatca tgacacggca chr6:170863022-170863102 71 3.18e-04 gggtaagcac tgttatca tt chr5:86447516-86447596 7 3.18e-04 GTTAAC TGTTATCA TCACAGAAAC chr10:73078779-73078859 58 3.48e-04 GGGTGACTCA CTTTTTCT CCTATAAAAT chr3:71257578-71257658 73 3.48e-04 ACAAGTTCCC CTTTTTCT chr3:10187507-10187587 29 3.48e-04 AAGTCAGTGG CTTTTTCT CTTTAGTTTG chr1:150228465-150228545 24 4.24e-04 TGGCAAGACA CGCTATCT GCCTTGGAAA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCTTATCT MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr5:67599740-67599820 1.6e-05 48_[+4]_24 chr11:73727494-73727574 1.6e-05 46_[+4]_26 chr5:95997598-95997678 1.6e-05 6_[+4]_66 chr8:3009710-3009790 1.6e-05 12_[+4]_60 chr4:153494082-153494162 1.6e-05 31_[+4]_41 chr12:4430055-4430135 1.6e-05 43_[+4]_29 chr16:67523140-67523220 1.6e-05 11_[+4]_61 chr20:20391522-20391602 3.2e-05 64_[+4]_8 chr11:47536983-47537063 3.2e-05 42_[+4]_30 chr11:74919679-74919759 3.2e-05 31_[+4]_41 chr20:47654662-47654742 3.2e-05 34_[+4]_38 chr1:211854310-211854390 3.2e-05 51_[+4]_21 chr22:21211785-21211865 3.2e-05 4_[+4]_68 chr1:109723911-109723991 6.3e-05 26_[+4]_46 chr7:134278866-134278946 6.3e-05 44_[+4]_28 chr16:30560855-30560935 6.3e-05 64_[+4]_8 chr1:244462779-244462859 6.3e-05 2_[+4]_70 chr3:194295764-194295844 6.3e-05 34_[+4]_38 chr17:41481369-41481449 6.3e-05 53_[+4]_19 chr16:66524744-66524824 6.3e-05 48_[+4]_24 chr22:21132137-21132217 7.8e-05 69_[+4]_3 chr1:233845962-233846042 7.8e-05 8_[+4]_64 chr4:108913509-108913589 7.8e-05 48_[+4]_24 chr6:159241522-159241602 0.00011 18_[+4]_54 chr18:60829169-60829249 0.00011 30_[+4]_42 chr12:31910156-31910236 0.00011 19_[+4]_53 chr7:107135400-107135480 0.00013 18_[+4]_54 chr22:22302163-22302243 0.00013 18_[+4]_54 chr6:136572716-136572796 0.00014 35_[+4]_37 chr11:96037301-96037381 0.00014 23_[+4]_49 chr4:48700503-48700583 0.00019 7_[+4]_65 chr7:84459193-84459273 0.00019 30_[+4]_42 chr6:106968868-106968948 0.00022 44_[+4]_28 chr5:10620619-10620699 0.00022 36_[+4]_36 chr18:67704087-67704167 0.00022 71_[+4]_1 chr1:116901797-116901877 0.00022 18_[+4]_54 chr17:29854768-29854848 0.00028 34_[+4]_38 chr10:17658482-17658562 0.00028 41_[+4]_31 chr8:23849085-23849165 0.00028 35_[+4]_37 chr1:223866743-223866823 0.00032 26_[+4]_46 chr6:170863022-170863102 0.00032 70_[+4]_2 chr5:86447516-86447596 0.00032 6_[+4]_66 chr10:73078779-73078859 0.00035 57_[+4]_15 chr3:71257578-71257658 0.00035 72_[+4] chr3:10187507-10187587 0.00035 28_[+4]_44 chr1:150228465-150228545 0.00042 23_[+4]_49 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCTTATCT MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF YCTTATCT width=8 seqs=46 chr5:67599740-67599820 ( 49) CCTTATCT 1 chr11:73727494-73727574 ( 47) CCTTATCT 1 chr5:95997598-95997678 ( 7) CCTTATCT 1 chr8:3009710-3009790 ( 13) CCTTATCT 1 chr4:153494082-153494162 ( 32) CCTTATCT 1 chr12:4430055-4430135 ( 44) CCTTATCT 1 chr16:67523140-67523220 ( 12) CCTTATCT 1 chr20:20391522-20391602 ( 65) TCTTATCT 1 chr11:47536983-47537063 ( 43) TCTTATCT 1 chr11:74919679-74919759 ( 32) TCTTATCT 1 chr20:47654662-47654742 ( 35) TCTTATCT 1 chr1:211854310-211854390 ( 52) TCTTATCT 1 chr22:21211785-21211865 ( 5) TCTTATCT 1 chr1:109723911-109723991 ( 27) CTTTATCT 1 chr7:134278866-134278946 ( 45) CTTTATCT 1 chr16:30560855-30560935 ( 65) CTTTATCT 1 chr1:244462779-244462859 ( 3) CTTTATCT 1 chr3:194295764-194295844 ( 35) CGTTATCT 1 chr17:41481369-41481449 ( 54) CTTTATCT 1 chr16:66524744-66524824 ( 49) CTTTATCT 1 chr22:21132137-21132217 ( 70) GCTTATCT 1 chr1:233845962-233846042 ( 9) GCTTATCT 1 chr4:108913509-108913589 ( 49) GCTTATCT 1 chr6:159241522-159241602 ( 19) TGTTATCT 1 chr18:60829169-60829249 ( 31) TGTTATCT 1 chr12:31910156-31910236 ( 20) TGTTATCT 1 chr7:107135400-107135480 ( 19) CCTTATCA 1 chr22:22302163-22302243 ( 19) CCTTATCA 1 chr6:136572716-136572796 ( 36) TCTTATCA 1 chr11:96037301-96037381 ( 24) TCTTATCA 1 chr4:48700503-48700583 ( 8) GGTTATCT 1 chr7:84459193-84459273 ( 31) GTTTATCT 1 chr6:106968868-106968948 ( 45) CCCTATCT 1 chr5:10620619-10620699 ( 37) TCTTTTCT 1 chr18:67704087-67704167 ( 72) CCCTATCT 1 chr1:116901797-116901877 ( 19) TCTTTTCT 1 chr17:29854768-29854848 ( 35) GCTTATCA 1 chr10:17658482-17658562 ( 42) GCTTATCA 1 chr8:23849085-23849165 ( 36) TCCTATCT 1 chr1:223866743-223866823 ( 27) TGTTATCA 1 chr6:170863022-170863102 ( 71) TGTTATCA 1 chr5:86447516-86447596 ( 7) TGTTATCA 1 chr10:73078779-73078859 ( 58) CTTTTTCT 1 chr3:71257578-71257658 ( 73) CTTTTTCT 1 chr3:10187507-10187587 ( 29) CTTTTTCT 1 chr1:150228465-150228545 ( 24) CGCTATCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCTTATCT MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.03184 E= 1.4e-005 -1217 96 -67 55 -1217 125 -30 -21 -1217 -150 -1217 186 -1217 -1217 -1217 199 177 -1217 -1217 -121 -1217 -1217 -1217 199 -1217 202 -1217 -1217 -42 -1217 -1217 168 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCTTATCT MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 46 E= 1.4e-005 0.000000 0.478261 0.152174 0.369565 0.000000 0.586957 0.195652 0.217391 0.000000 0.086957 0.000000 0.913043 0.000000 0.000000 0.000000 1.000000 0.891304 0.000000 0.000000 0.108696 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.195652 0.000000 0.000000 0.804348 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCTTATCT MEME-4 regular expression -------------------------------------------------------------------------------- [CT][CT]TTATCT -------------------------------------------------------------------------------- Time 15.67 secs. ******************************************************************************** ******************************************************************************** MOTIF CWGCAGBK MEME-5 width = 8 sites = 49 llr = 384 E-value = 1.6e-005 ******************************************************************************** -------------------------------------------------------------------------------- Motif CWGCAGBK MEME-5 Description -------------------------------------------------------------------------------- Simplified A :4::7:1: pos.-specific C a::a::4: probability G ::a::a24 matrix T :6::3:36 bits 2.1 * ** 1.8 * ** * 1.6 * ** * 1.4 * ** * Relative 1.2 * ** * Entropy 1.0 ****** * (11.3 bits) 0.8 ****** * 0.6 ****** * 0.4 ****** * 0.2 ******** 0.0 -------- Multilevel CTGCAGCT consensus A T TG sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWGCAGBK MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr9:114364089-114364169 35 1.43e-05 GTCTCAAAGG CTGCAGCT TGTCAAGTCA chr15:72524647-72524727 15 1.43e-05 TACCCGCTGC CTGCAGCT GAATCACAGG chr8:23849085-23849165 44 1.43e-05 CATCCTATCT CTGCAGCT CTAACCCTGT chr4:39559999-39560079 26 1.43e-05 atcacagctg ctgcagct gcacagataa chr19:40724246-40724326 67 1.43e-05 GCCGCCGCCG CTGCAGCT ACCGCA chr16:67523140-67523220 26 1.43e-05 atctgtgcag ctgcagct tgatttttcc chr13:47695664-47695744 52 2.90e-05 gataaggaaa ctgcagtt cagagatgta chr6:25974301-25974381 70 2.90e-05 tctgataagg ctgcagtt aag chrX:117858993-117859073 19 2.90e-05 TCCTTGTCTA CTGCAGTT CCTGGAAAGC chr1:20848907-20848987 70 2.90e-05 TCAGTCATTG CTGCAGTT GAC chr15:43577890-43577970 41 4.39e-05 TTTAATAAGG CAGCAGCT CCCTCTTGTG chr1:203648525-203648605 7 4.39e-05 TTGTGC CAGCAGCT TAGCGCTTGA chr1:52432307-52432387 12 4.39e-05 CTTACTTCCT CAGCAGCT GGTTCCTACA chr12:133712484-13371256 40 4.39e-05 TATCTTTTGT CAGCAGCT TTTGCTAGTT chr4:128454696-128454776 66 4.39e-05 CTCTGTTTCA CAGCAGCT GAGTTGT chr11:61876570-61876650 20 4.39e-05 gacactgtta cagcagct ctagcaagtg chr1:145059132-145059212 9 5.79e-05 AAAACCAT CTGCAGGT GCCCCCTGCT chr8:61705477-61705557 31 8.68e-05 CCACAAAACA CTGCAGCG CAGGTGTTGA chr20:20391522-20391602 25 1.29e-04 AGCCTTCTGC CTGCTGCT CCTGGCTCCC chr9:123659579-123659659 71 1.29e-04 GACTCTCCAC CTGCAGTG TG chr18:60829169-60829249 14 1.29e-04 TCCATGTGAC CTGCAGTG CTGGTTGAGT chr1:27372548-27372628 33 1.29e-04 CAGTAACCGC CAGCAGGT GGCGCTGAGG chr1:65744884-65744964 52 1.29e-04 GCTGTGACTC CTGCTGCT GTGAGATAAA chr22:21974461-21974541 51 1.29e-04 ggagataaga ctgcagtg agctgtgatt chr18:12893949-12894029 40 1.29e-04 ctgtctcccc ctgctgct gccttaataa chr1:9844762-9844842 21 1.29e-04 GGAACACTGC CAGCAGGT GGTGACAGGT chr20:37499534-37499614 67 1.29e-04 TACTGCAGTC CTGCAGTG ATTCAC chr9:96830707-96830787 11 1.71e-04 ttgggtttgt ctgctgtt tcctcatgat chr6:30910542-30910622 4 1.71e-04 AAC CTGCAGGG GGCGGAAGGG chr7:50626230-50626310 15 2.00e-04 CCAAACAAAT CAGCAgtg ctcaagctcc chr9:102864032-102864112 55 2.00e-04 agctgattaa cagctgct ccctttagat chr15:40882085-40882165 59 2.00e-04 CTTGCAGTTG CAGCTGCT CCAGTAGATG chr1:113216380-113216460 24 2.13e-04 GTGTGGCCTC CTGCTGGT AGCTACTATG chr17:40903157-40903237 68 2.55e-04 TCTTCCCTAT CAGCAGGG TCCCA chr9:135870003-135870083 47 2.55e-04 GCCACTTCTG CAGCAGGG CGGGGCAAGG chr19:5971927-5972007 10 2.55e-04 ccacaggcg cagctgtt ccttagcact chr7:84459193-84459273 3 2.55e-04 CA CAGCAGGG ACAATAATTC chr16:75543463-75543543 28 2.83e-04 CCCCGGACTC CTGCTGTG GAAGGCTTCT chr4:99722500-99722580 21 2.83e-04 CAAAGTTGCA CTGCTGTG TCAGAGATTA chr2:85814850-85814930 55 2.83e-04 ctcagtcact cagctggt gagtggcaga chr1:8940335-8940415 70 2.83e-04 TAAAGATACT CTGCTGTG GCC chr19:29176861-29176941 8 2.83e-04 Ttttctc cagctggt tgcaaaagag chr17:35425199-35425279 51 3.10e-04 AATCAGAGCT CTGCTGGG ACCTGAGGTC chr5:67599740-67599820 1 3.24e-04 . cagctgtg ggaagtgggc chr22:20827622-20827702 35 3.52e-04 aaaatctgga cagctggg agtcccgtga chr7:129425001-129425081 54 3.68e-04 CCGCAGCCTT CAGCAGAT TATCCAAAGG chr19:39872653-39872733 32 3.82e-04 GCCACTGGGG CTGCAGAG ACAGATAAGG chr17:41481369-41481449 70 4.12e-04 CTCCTAAGCC CAGCAGAG GTC chr1:45301722-45301802 19 5.01e-04 GTGAGGCTGT CAGCAcct tcctcctttc -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWGCAGBK MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:114364089-114364169 1.4e-05 34_[+5]_38 chr15:72524647-72524727 1.4e-05 14_[+5]_58 chr8:23849085-23849165 1.4e-05 43_[+5]_29 chr4:39559999-39560079 1.4e-05 25_[+5]_47 chr19:40724246-40724326 1.4e-05 66_[+5]_6 chr16:67523140-67523220 1.4e-05 25_[+5]_47 chr13:47695664-47695744 2.9e-05 51_[+5]_21 chr6:25974301-25974381 2.9e-05 69_[+5]_3 chrX:117858993-117859073 2.9e-05 18_[+5]_54 chr1:20848907-20848987 2.9e-05 69_[+5]_3 chr15:43577890-43577970 4.4e-05 40_[+5]_32 chr1:203648525-203648605 4.4e-05 6_[+5]_66 chr1:52432307-52432387 4.4e-05 11_[+5]_61 chr12:133712484-13371256 4.4e-05 39_[+5]_33 chr4:128454696-128454776 4.4e-05 65_[+5]_7 chr11:61876570-61876650 4.4e-05 19_[+5]_53 chr1:145059132-145059212 5.8e-05 8_[+5]_64 chr8:61705477-61705557 8.7e-05 30_[+5]_42 chr20:20391522-20391602 0.00013 24_[+5]_48 chr9:123659579-123659659 0.00013 70_[+5]_2 chr18:60829169-60829249 0.00013 13_[+5]_59 chr1:27372548-27372628 0.00013 32_[+5]_40 chr1:65744884-65744964 0.00013 51_[+5]_21 chr22:21974461-21974541 0.00013 50_[+5]_22 chr18:12893949-12894029 0.00013 39_[+5]_33 chr1:9844762-9844842 0.00013 20_[+5]_52 chr20:37499534-37499614 0.00013 66_[+5]_6 chr9:96830707-96830787 0.00017 10_[+5]_62 chr6:30910542-30910622 0.00017 3_[+5]_69 chr7:50626230-50626310 0.0002 14_[+5]_58 chr9:102864032-102864112 0.0002 54_[+5]_18 chr15:40882085-40882165 0.0002 58_[+5]_14 chr1:113216380-113216460 0.00021 23_[+5]_49 chr17:40903157-40903237 0.00026 67_[+5]_5 chr9:135870003-135870083 0.00026 46_[+5]_26 chr19:5971927-5972007 0.00026 9_[+5]_63 chr7:84459193-84459273 0.00026 2_[+5]_70 chr16:75543463-75543543 0.00028 27_[+5]_45 chr4:99722500-99722580 0.00028 20_[+5]_52 chr2:85814850-85814930 0.00028 54_[+5]_18 chr1:8940335-8940415 0.00028 69_[+5]_3 chr19:29176861-29176941 0.00028 7_[+5]_65 chr17:35425199-35425279 0.00031 50_[+5]_22 chr5:67599740-67599820 0.00032 [+5]_72 chr22:20827622-20827702 0.00035 34_[+5]_38 chr7:129425001-129425081 0.00037 53_[+5]_19 chr19:39872653-39872733 0.00038 31_[+5]_41 chr17:41481369-41481449 0.00041 69_[+5]_3 chr1:45301722-45301802 0.0005 18_[+5]_54 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWGCAGBK MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CWGCAGBK width=8 seqs=49 chr9:114364089-114364169 ( 35) CTGCAGCT 1 chr15:72524647-72524727 ( 15) CTGCAGCT 1 chr8:23849085-23849165 ( 44) CTGCAGCT 1 chr4:39559999-39560079 ( 26) CTGCAGCT 1 chr19:40724246-40724326 ( 67) CTGCAGCT 1 chr16:67523140-67523220 ( 26) CTGCAGCT 1 chr13:47695664-47695744 ( 52) CTGCAGTT 1 chr6:25974301-25974381 ( 70) CTGCAGTT 1 chrX:117858993-117859073 ( 19) CTGCAGTT 1 chr1:20848907-20848987 ( 70) CTGCAGTT 1 chr15:43577890-43577970 ( 41) CAGCAGCT 1 chr1:203648525-203648605 ( 7) CAGCAGCT 1 chr1:52432307-52432387 ( 12) CAGCAGCT 1 chr12:133712484-13371256 ( 40) CAGCAGCT 1 chr4:128454696-128454776 ( 66) CAGCAGCT 1 chr11:61876570-61876650 ( 20) CAGCAGCT 1 chr1:145059132-145059212 ( 9) CTGCAGGT 1 chr8:61705477-61705557 ( 31) CTGCAGCG 1 chr20:20391522-20391602 ( 25) CTGCTGCT 1 chr9:123659579-123659659 ( 71) CTGCAGTG 1 chr18:60829169-60829249 ( 14) CTGCAGTG 1 chr1:27372548-27372628 ( 33) CAGCAGGT 1 chr1:65744884-65744964 ( 52) CTGCTGCT 1 chr22:21974461-21974541 ( 51) CTGCAGTG 1 chr18:12893949-12894029 ( 40) CTGCTGCT 1 chr1:9844762-9844842 ( 21) CAGCAGGT 1 chr20:37499534-37499614 ( 67) CTGCAGTG 1 chr9:96830707-96830787 ( 11) CTGCTGTT 1 chr6:30910542-30910622 ( 4) CTGCAGGG 1 chr7:50626230-50626310 ( 15) CAGCAGTG 1 chr9:102864032-102864112 ( 55) CAGCTGCT 1 chr15:40882085-40882165 ( 59) CAGCTGCT 1 chr1:113216380-113216460 ( 24) CTGCTGGT 1 chr17:40903157-40903237 ( 68) CAGCAGGG 1 chr9:135870003-135870083 ( 47) CAGCAGGG 1 chr19:5971927-5972007 ( 10) CAGCTGTT 1 chr7:84459193-84459273 ( 3) CAGCAGGG 1 chr16:75543463-75543543 ( 28) CTGCTGTG 1 chr4:99722500-99722580 ( 21) CTGCTGTG 1 chr2:85814850-85814930 ( 55) CAGCTGGT 1 chr1:8940335-8940415 ( 70) CTGCTGTG 1 chr19:29176861-29176941 ( 8) CAGCTGGT 1 chr17:35425199-35425279 ( 51) CTGCTGGG 1 chr5:67599740-67599820 ( 1) CAGCTGTG 1 chr22:20827622-20827702 ( 35) CAGCTGGG 1 chr7:129425001-129425081 ( 54) CAGCAGAT 1 chr19:39872653-39872733 ( 32) CTGCAGAG 1 chr17:41481369-41481449 ( 70) CAGCAGAG 1 chr1:45301722-45301802 ( 19) CAGCACCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWGCAGBK MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.00713 E= 1.6e-005 -1226 202 -1226 -1226 78 -1226 -1226 113 -1226 -1226 205 -1226 -1226 202 -1226 -1226 137 -1226 -1226 38 -1226 -359 202 -1226 -209 66 2 28 -1226 -1226 61 133 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWGCAGBK MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 49 E= 1.6e-005 0.000000 1.000000 0.000000 0.000000 0.448980 0.000000 0.000000 0.551020 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.673469 0.000000 0.000000 0.326531 0.000000 0.020408 0.979592 0.000000 0.061224 0.387755 0.244898 0.306122 0.000000 0.000000 0.367347 0.632653 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CWGCAGBK MEME-5 regular expression -------------------------------------------------------------------------------- C[TA]GC[AT]G[CTG][TG] -------------------------------------------------------------------------------- Time 19.03 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:16939193-16939273 5.30e-02 28_[+2(4.94e-05)]_44 chr21:47012866-47012946 3.63e-03 42_[+1(4.60e-05)]_30 chr11:61876570-61876650 6.30e-03 19_[+5(4.39e-05)]_53 chr1:154077028-154077108 4.30e-03 13_[+2(1.65e-05)]_59 chr3:10187507-10187587 1.39e-04 55_[+1(1.50e-05)]_17 chr11:96037301-96037381 5.30e-04 80 chr2:192713665-192713745 1.97e-01 80 chr17:42084521-42084601 5.06e-02 12_[+2(4.94e-05)]_60 chr1:183614727-183614807 3.10e-03 33_[+2(1.65e-05)]_20_[+2(1.65e-05)]_\ 11 chr16:67523140-67523220 2.53e-05 11_[+4(1.57e-05)]_6_[+5(1.43e-05)]_\ 47 chr6:142433761-142433841 3.89e-03 50_[+2(6.59e-05)]_5_[+2(1.65e-05)]_\ 9 chr6:30910542-30910622 6.81e-03 44_[+1(7.54e-05)]_28 chr1:181687340-181687420 7.54e-03 80 chr20:37499534-37499614 1.30e-03 30_[+1(4.60e-05)]_31_[+1(4.60e-05)]_\ 3 chr2:152991620-152991700 9.11e-02 45_[+1(7.54e-05)]_27 chr1:245498303-245498383 5.83e-04 16_[+1(1.50e-05)]_56 chr13:41255654-41255734 2.85e-03 80 chr1:19986450-19986530 9.67e-01 80 chr13:111064704-11106478 1.09e-02 80 chr12:95494179-95494259 2.04e-02 80 chr12:794734-794814 3.18e-04 34_[+1(1.50e-05)]_20_[+2(4.94e-05)]_\ 10 chr20:37089036-37089116 1.73e-01 80 chr12:123002498-12300257 2.81e-04 57_[+2(6.59e-05)]_15 chr16:69830557-69830637 2.41e-03 66_[+2(1.65e-05)]_6 chr1:155829353-155829433 7.80e-01 80 chr11:85753137-85753217 7.48e-03 65_[+1(7.54e-05)]_7 chr7:30280120-30280200 1.44e-01 80 chr10:1096216-1096296 1.82e-02 45_[+3(3.31e-05)]_27 chr1:20848907-20848987 1.78e-03 31_[+2(4.94e-05)]_30_[+5(2.90e-05)]_\ 3 chr12:1281005-1281085 9.06e-02 80 chr6:161827806-161827886 7.82e-01 80 chr12:10902913-10902993 4.40e-03 44_[+2(4.94e-05)]_28 chr17:35425199-35425279 5.85e-03 80 chr1:113216380-113216460 4.96e-02 80 chr2:148602382-148602462 1.40e-01 25_[+1(4.60e-05)]_4_[+1(4.60e-05)]_\ 35 chr16:66524744-66524824 1.92e-04 48_[+4(6.31e-05)]_24 chr12:109217688-10921776 3.92e-03 21_[+1(1.50e-05)]_51 chr7:84459193-84459273 3.08e-04 80 chr7:45129125-45129205 8.32e-01 80 chr7:107821687-107821767 1.37e-02 62_[+2(9.75e-05)]_10 chr5:159546921-159547001 6.02e-02 3_[+2(4.94e-05)]_69 chr1:200975753-200975833 1.97e-01 80 chr2:111920517-111920597 1.52e-03 [+2(4.94e-05)]_1_[+1(7.54e-05)]_63 chr1:9844762-9844842 2.03e-02 80 chr12:4430055-4430135 1.29e-03 26_[+2(9.75e-05)]_9_[+4(1.57e-05)]_\ 29 chr6:136572716-136572796 2.21e-01 80 chrX:117858993-117859073 8.79e-03 18_[+5(2.90e-05)]_54 chr17:62530075-62530155 2.52e-01 80 chr5:173043063-173043143 1.93e-02 27_[+1(7.54e-05)]_45 chr22:22062064-22062144 4.05e-02 41_[+3(1.64e-05)]_31 chr9:132806080-132806160 1.11e-01 80 chr1:116901797-116901877 1.42e-03 62_[+2(6.59e-05)]_10 chr7:45027729-45027809 1.82e-02 42_[+3(3.31e-05)]_30 chr10:45454756-45454836 1.66e-03 27_[+1(4.60e-05)]_45 chr19:40724246-40724326 8.67e-02 66_[+5(1.43e-05)]_6 chr18:755701-755781 9.75e-03 38_[+3(5.08e-05)]_34 chr3:71257578-71257658 3.25e-02 80 chr2:27201310-27201390 4.53e-02 37_[+1(3.04e-05)]_35 chr4:128454696-128454776 1.23e-04 52_[+2(4.94e-05)]_5_[+5(4.39e-05)]_\ 7 chr18:12893949-12894029 5.43e-03 80 chr11:72526302-72526382 1.16e-03 10_[+1(7.54e-05)]_14_[+2(9.75e-05)]_\ 40 chr19:1470688-1470768 2.30e-03 19_[+2(1.65e-05)]_53 chr19:49141539-49141619 5.95e-02 80 chr22:21211785-21211865 9.35e-02 4_[+4(3.17e-05)]_68 chr1:228352372-228352452 6.14e-03 [+1(1.50e-05)]_72 chr12:96883271-96883351 2.37e-01 80 chr4:164101388-164101468 2.26e-03 34_[+3(3.31e-05)]_38 chr4:40623775-40623855 3.26e-02 80 chr9:130955305-130955385 2.49e-02 8_[+2(1.65e-05)]_64 chr9:135853998-135854078 1.70e-01 80 chr1:150228465-150228545 4.38e-03 45_[+2(6.59e-05)]_27 chr5:138524369-138524449 1.34e-01 80 chr19:5971927-5972007 3.85e-04 31_[+2(1.65e-05)]_41 chr14:21151546-21151626 1.78e-02 20_[+2(4.94e-05)]_52 chr18:33012810-33012890 1.76e-02 36_[+1(7.54e-05)]_36 chr4:48700503-48700583 1.19e-02 80 chr6:159238407-159238487 1.95e-01 80 chr4:108913509-108913589 1.16e-02 48_[+4(7.85e-05)]_24 chr4:39559999-39560079 2.65e-05 14_[+2(4.94e-05)]_3_[+5(1.43e-05)]_\ 3_[+3(3.31e-05)]_6_[+3(3.31e-05)]_22 chr1:211854310-211854390 1.86e-02 51_[+4(3.17e-05)]_21 chr4:153494082-153494162 8.92e-05 31_[+4(1.57e-05)]_17_[+2(1.65e-05)]_\ 16 chr7:124702207-124702287 1.00e-02 18_[+1(1.50e-05)]_54 chr5:86447516-86447596 1.06e-03 33_[+1(3.04e-05)]_39 chr5:173311843-173311923 1.94e-01 80 chr8:61705477-61705557 2.59e-04 30_[+5(8.68e-05)]_42 chr20:48767722-48767802 1.01e-02 40_[+3(5.08e-05)]_32 chr2:190953769-190953849 1.55e-02 59_[+2(4.94e-05)]_13 chr8:3009710-3009790 2.12e-03 12_[+4(1.57e-05)]_60 chr13:96137559-96137639 3.30e-02 80 chr20:47654662-47654742 3.78e-03 34_[+4(3.17e-05)]_38 chr5:180131520-180131600 2.26e-03 36_[+1(7.54e-05)]_36 chr19:54605729-54605809 1.34e-01 80 chr19:2974585-2974665 7.24e-02 45_[+1(7.54e-05)]_27 chr5:95997598-95997678 7.01e-03 6_[+4(1.57e-05)]_66 chr7:97847741-97847821 6.59e-01 80 chr8:23849085-23849165 2.17e-05 43_[+5(1.43e-05)]_29 chr7:102624240-102624320 7.26e-05 49_[+2(6.59e-05)]_14_[+3(1.64e-05)]_\ 1 chr1:231108799-231108879 2.85e-01 80 chr7:129425001-129425081 1.16e-01 80 chr12:117627564-11762764 8.28e-01 80 chr12:31910156-31910236 1.03e-01 80 chr1:211787495-211787575 3.63e-02 80 chr11:74919679-74919759 2.92e-02 31_[+4(3.17e-05)]_41 chr15:72524647-72524727 6.90e-06 14_[+5(1.43e-05)]_1_[+2(4.94e-05)]_\ 24_[+3(3.31e-05)]_17 chr9:132641517-132641597 9.67e-03 6_[+1(7.54e-05)]_66 chr9:116160589-116160669 1.32e-03 46_[+2(4.94e-05)]_26 chr17:41481369-41481449 1.03e-03 53_[+4(6.31e-05)]_19 chr12:133712484-13371256 2.18e-04 26_[+4(7.85e-05)]_5_[+5(4.39e-05)]_\ 33 chr7:30978505-30978585 3.00e-01 80 chr19:29176861-29176941 1.50e-01 80 chr3:194295764-194295844 1.22e-03 26_[+2(1.65e-05)]_[+4(6.31e-05)]_38 chr2:42876785-42876865 1.42e-02 80 chr22:21221903-21221983 9.76e-02 80 chr8:126935427-126935507 6.83e-03 63_[+1(1.50e-05)]_9 chr22:21974461-21974541 2.82e-05 41_[+3(1.64e-05)]_11_[+1(1.50e-05)]_\ 12 chr1:8940335-8940415 3.52e-03 55_[+3(5.08e-05)]_17 chr22:21984411-21984491 4.69e-01 80 chr3:185823410-185823490 2.09e-02 52_[+2(4.94e-05)]_20 chr11:118444100-11844418 3.84e-01 80 chr17:74449353-74449433 8.76e-01 80 chr17:46949178-46949258 9.35e-01 80 chr1:45301722-45301802 1.14e-02 80 chr16:21623536-21623616 3.42e-03 40_[+2(6.59e-05)]_32 chr11:44564036-44564116 7.79e-01 80 chr1:65744884-65744964 4.57e-04 61_[+3(5.08e-05)]_11 chr18:67704087-67704167 6.32e-02 80 chr12:52311684-52311764 4.64e-03 80 chr6:36989691-36989771 4.15e-02 38_[+1(7.54e-05)]_34 chr1:233845962-233846042 2.74e-02 8_[+4(7.85e-05)]_64 chr12:7394167-7394247 8.75e-03 47_[+2(4.94e-05)]_25 chr1:9679089-9679169 2.08e-02 35_[+1(1.50e-05)]_37 chr4:48782195-48782275 4.50e-02 24_[+1(7.54e-05)]_14_[+1(3.04e-05)]_\ 26 chr1:27372548-27372628 1.06e-02 54_[+2(6.59e-05)]_18 chr1:116963154-116963234 6.50e-02 80 chr15:40882085-40882165 3.31e-03 80 chr9:114364089-114364169 2.38e-03 34_[+5(1.43e-05)]_38 chr7:30510001-30510081 2.02e-01 80 chr6:143419345-143419425 7.44e-02 80 chr7:99160692-99160772 1.15e-01 45_[+2(6.59e-05)]_27 chr19:9945338-9945418 3.06e-01 80 chr5:176884783-176884863 4.07e-02 80 chr18:11981081-11981161 4.43e-01 80 chr9:102864032-102864112 1.48e-02 80 chr1:244462779-244462859 3.71e-02 2_[+4(6.31e-05)]_70 chr11:47536983-47537063 3.62e-03 42_[+4(3.17e-05)]_30 chr7:137671309-137671389 1.71e-03 32_[+2(9.75e-05)]_40 chr3:24347400-24347480 3.43e-02 80 chr1:14769753-14769833 3.91e-02 30_[+3(1.64e-05)]_42 chr6:25974301-25974381 5.36e-04 69_[+5(2.90e-05)]_3 chr9:96830707-96830787 3.99e-04 32_[+1(7.54e-05)]_40 chr14:77506836-77506916 4.36e-02 80 chr6:30956366-30956446 5.69e-03 56_[+3(1.64e-05)]_16 chr1:205218328-205218408 3.98e-01 80 chr16:30560855-30560935 3.26e-04 24_[+1(7.54e-05)]_32_[+4(6.31e-05)]_\ 8 chr17:74351110-74351190 2.30e-01 80 chr5:172192439-172192519 2.15e-01 80 chr11:73727494-73727574 2.60e-03 46_[+4(1.57e-05)]_26 chr10:73078779-73078859 2.98e-01 80 chr13:50735394-50735474 5.75e-01 80 chrX:118611854-118611934 2.59e-02 80 chr6:138131776-138131856 1.60e-01 80 chr7:2204977-2205057 5.25e-01 80 chr10:17658482-17658562 1.15e-01 80 chr13:114035508-11403558 7.31e-01 80 chr22:20827622-20827702 3.86e-03 80 chr22:21132137-21132217 1.82e-02 69_[+4(7.85e-05)]_3 chr1:52432307-52432387 2.94e-03 11_[+5(4.39e-05)]_19_[+3(5.08e-05)]_\ 34 chr17:29854768-29854848 9.66e-05 13_[+2(1.65e-05)]_42_[+1(7.54e-05)]_\ 9 chr7:150484796-150484876 1.97e-02 80 chr11:85960525-85960605 4.06e-04 29_[+1(7.54e-05)]_6_[+1(7.54e-05)]_\ 18_[+3(1.64e-05)]_3 chr16:14579281-14579361 6.33e-01 80 chr2:85814850-85814930 4.73e-02 80 chr17:25615938-25616018 7.46e-03 19_[+2(4.94e-05)]_8_[+2(4.94e-05)]_\ 8_[+2(4.94e-05)]_21 chr5:67599740-67599820 8.86e-05 48_[+4(1.57e-05)]_2_[+3(5.08e-05)]_\ 14 chr4:99722500-99722580 4.09e-04 57_[+2(9.75e-05)]_15 chr8:142046293-142046373 5.02e-02 63_[+1(7.54e-05)]_9 chr15:55611920-55612000 4.41e-01 80 chr2:220341165-220341245 5.23e-01 80 chr20:42305840-42305920 2.82e-02 41_[+3(1.64e-05)]_31 chr1:169162852-169162932 1.25e-04 10_[+3(1.64e-05)]_25_[+1(7.54e-05)]_\ 29 chr6:170863022-170863102 1.35e-04 32_[+2(4.94e-05)]_40 chr16:50105152-50105232 2.27e-02 80 chr3:17988324-17988404 1.75e-03 80 chr4:80120226-80120306 3.50e-01 80 chr18:60829169-60829249 1.07e-03 80 chr19:56213855-56213935 4.01e-03 47_[+4(7.85e-05)]_25 chr15:34949852-34949932 1.36e-02 80 chr2:178130742-178130822 6.49e-02 80 chr16:75543463-75543543 2.34e-04 80 chr5:10620619-10620699 5.34e-02 80 chr5:134509464-134509544 1.07e-03 80 chr14:22966910-22966990 1.31e-03 49_[+3(1.64e-05)]_23 chr19:14116340-14116420 7.45e-01 80 chr7:86849068-86849148 2.02e-01 50_[+2(6.59e-05)]_22 chr17:38296192-38296272 1.05e-01 80 chr7:134278866-134278946 6.84e-02 44_[+4(6.31e-05)]_28 chr20:30538187-30538267 9.48e-02 80 chr19:13828318-13828398 3.05e-02 25_[+3(5.08e-05)]_47 chr11:12863893-12863973 7.73e-02 80 chr9:135870003-135870083 1.45e-01 80 chr4:170547178-170547258 8.42e-03 50_[+1(8.96e-05)]_22 chr7:99766166-99766246 4.91e-01 80 chr1:203648525-203648605 2.43e-05 6_[+5(4.39e-05)]_66 chr9:123697894-123697974 7.99e-02 80 chr19:18668366-18668446 7.52e-01 80 chr19:3035953-3036033 1.67e-01 80 chr2:42149455-42149535 4.39e-01 80 chr9:123659579-123659659 1.10e-01 80 chr2:47432781-47432861 1.56e-04 6_[+1(1.50e-05)]_66 chr20:20391522-20391602 4.83e-03 2_[+4(7.85e-05)]_54_[+4(3.17e-05)]_\ 8 chr1:87230913-87230993 1.52e-01 80 chr8:61488610-61488690 3.59e-02 80 chr6:111872767-111872847 1.72e-02 59_[+2(9.75e-05)]_13 chr19:39872653-39872733 1.91e-02 40_[+3(3.31e-05)]_32 chr7:50626230-50626310 3.36e-03 80 chr1:151960973-151961053 3.43e-01 80 chr6:159241522-159241602 1.22e-01 80 chr1:109757553-109757633 2.89e-01 80 chr1:223866743-223866823 2.37e-02 80 chr2:169853646-169853726 6.41e-01 80 chr16:2844614-2844694 1.35e-01 80 chr20:57607748-57607828 3.82e-02 80 chr22:40895301-40895381 6.43e-03 80 chr6:106968868-106968948 2.90e-02 80 chr15:43577890-43577970 5.69e-04 10_[+2(4.94e-05)]_22_[+5(4.39e-05)]_\ 32 chr3:8899695-8899775 4.07e-02 80 chr1:109723911-109723991 3.05e-03 18_[+3(5.08e-05)]_[+4(6.31e-05)]_46 chr20:49330333-49330413 1.56e-03 40_[+1(3.04e-05)]_32 chr1:145059132-145059212 8.07e-02 8_[+5(5.79e-05)]_64 chr3:39195398-39195478 6.25e-01 80 chr20:32278034-32278114 1.13e-02 80 chr9:34989523-34989603 7.21e-03 11_[+2(1.65e-05)]_61 chr1:90289328-90289408 8.53e-02 59_[+3(6.89e-05)]_13 chr2:32946568-32946648 7.67e-03 80 chr22:22302163-22302243 2.07e-02 80 chr1:6577715-6577795 3.05e-02 71_[+3(5.08e-05)]_1 chr7:107135400-107135480 2.85e-02 80 chr22:22146170-22146250 1.53e-01 80 chr1:20524106-20524186 1.74e-01 80 chr19:13694057-13694137 1.18e-01 80 chr15:48847477-48847557 3.00e-02 24_[+1(3.04e-05)]_48 chr3:124491300-124491380 1.04e-02 48_[+2(4.94e-05)]_24 chr17:67062813-67062893 6.66e-01 80 chr18:33039014-33039094 4.64e-02 80 chr17:40903157-40903237 1.95e-03 80 chr6:44649728-44649808 2.34e-03 16_[+2(6.59e-05)]_21_[+1(7.54e-05)]_\ 27 chr13:47695664-47695744 1.17e-03 39_[+3(3.31e-05)]_4_[+5(2.90e-05)]_\ 21 chr6:167356431-167356511 1.10e-01 80 chr3:170874355-170874435 4.08e-02 80 chr6:14039415-14039495 5.88e-02 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n09.farnam.hpc.yale.internal ********************************************************************************