******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/NKRF.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr7:44078860-44078940 1.0000 80 chr17:25853699-25853779 1.0000 80 chr3:49966997-49967077 1.0000 80 chr16:30773239-30773319 1.0000 80 chr3:20083055-20083135 1.0000 80 chr19:54666231-54666311 1.0000 80 chr15:85524017-85524097 1.0000 80 chr16:72042742-72042822 1.0000 80 chr4:81256969-81257049 1.0000 80 chr17:49336707-49336787 1.0000 80 chr6:7312706-7312786 1.0000 80 chr22:31460142-31460222 1.0000 80 chr8:117778981-117779061 1.0000 80 chr11:113185414-11318549 1.0000 80 chr16:29624187-29624267 1.0000 80 chrX:152735420-152735500 1.0000 80 chr21:33765199-33765279 1.0000 80 chr15:41708905-41708985 1.0000 80 chr1:156251121-156251201 1.0000 80 chr16:4784597-4784677 1.0000 80 chr20:44859589-44859669 1.0000 80 chr6:20401553-20401633 1.0000 80 chr1:100435869-100435949 1.0000 80 chr10:104474507-10447458 1.0000 80 chr15:68522419-68522499 1.0000 80 chr2:170684874-170684954 1.0000 80 chr10:99160982-99161062 1.0000 80 chr15:85143748-85143828 1.0000 80 chr5:175815504-175815584 1.0000 80 chr4:110736962-110737042 1.0000 80 chr6:86351702-86351782 1.0000 80 chr10:26986915-26986995 1.0000 80 chr15:41407808-41407888 1.0000 80 chr19:50321046-50321126 1.0000 80 chr7:65580500-65580580 1.0000 80 chr8:144025195-144025275 1.0000 80 chr12:53400901-53400981 1.0000 80 chr2:43822834-43822914 1.0000 80 chr12:125473557-12547363 1.0000 80 chr21:46961655-46961735 1.0000 80 chr4:7044568-7044648 1.0000 80 chr2:68385086-68385166 1.0000 80 chr20:3190247-3190327 1.0000 80 chr19:49631626-49631706 1.0000 80 chr19:1864287-1864367 1.0000 80 chr14:73393246-73393326 1.0000 80 chr6:33256883-33256963 1.0000 80 chr19:13002060-13002140 1.0000 80 chr16:11350354-11350434 1.0000 80 chr5:72861599-72861679 1.0000 80 chr11:65624492-65624572 1.0000 80 chr2:88991394-88991474 1.0000 80 chr3:194392772-194392852 1.0000 80 chr9:132020896-132020976 1.0000 80 chr12:105380170-10538025 1.0000 80 chr8:95908075-95908155 1.0000 80 chr4:57302528-57302608 1.0000 80 chr10:75911056-75911136 1.0000 80 chr9:131133696-131133776 1.0000 80 chr2:198570144-198570224 1.0000 80 chr20:30467623-30467703 1.0000 80 chr10:102747364-10274744 1.0000 80 chr16:30418628-30418708 1.0000 80 chr22:32058090-32058170 1.0000 80 chr7:150759591-150759671 1.0000 80 chr7:116151810-116151890 1.0000 80 chr12:64174100-64174180 1.0000 80 chr9:4793043-4793123 1.0000 80 chr9:131218098-131218178 1.0000 80 chr1:245026161-245026241 1.0000 80 chr7:75072189-75072269 1.0000 80 chr14:102771344-10277142 1.0000 80 chr8:144416858-144416938 1.0000 80 chr12:100594383-10059446 1.0000 80 chr2:131967130-131967210 1.0000 80 chr17:79980503-79980583 1.0000 80 chr16:69166570-69166650 1.0000 80 chr9:111696840-111696920 1.0000 80 chr11:66057117-66057197 1.0000 80 chr6:5261333-5261413 1.0000 80 chr19:17690771-17690851 1.0000 80 chr3:12526178-12526258 1.0000 80 chr17:30228556-30228636 1.0000 80 chr1:44445593-44445673 1.0000 80 chr15:75742912-75742992 1.0000 80 chr1:145826901-145826981 1.0000 80 chr1:156542244-156542324 1.0000 80 chr22:19166624-19166704 1.0000 80 chr17:4458484-4458564 1.0000 80 chr17:73285226-73285306 1.0000 80 chr16:56485506-56485586 1.0000 80 chr20:20033222-20033302 1.0000 80 chr12:109535658-10953573 1.0000 80 chr8:92082643-92082723 1.0000 80 chr19:59085108-59085188 1.0000 80 chr19:45682121-45682201 1.0000 80 chr2:32853241-32853321 1.0000 80 chr19:55691502-55691582 1.0000 80 chr9:127963008-127963088 1.0000 80 chr9:33473825-33473905 1.0000 80 chr3:51975859-51975939 1.0000 80 chr19:1605704-1605784 1.0000 80 chr7:100450048-100450128 1.0000 80 chr12:50506033-50506113 1.0000 80 chr12:101673930-10167401 1.0000 80 chr11:107436315-10743639 1.0000 80 chr1:33501798-33501878 1.0000 80 chr3:195869986-195870066 1.0000 80 chr12:110841326-11084140 1.0000 80 chr5:137514806-137514886 1.0000 80 chr21:34100684-34100764 1.0000 80 chr19:41109650-41109730 1.0000 80 chr1:230562399-230562479 1.0000 80 chr17:71088772-71088852 1.0000 80 chr5:180229492-180229572 1.0000 80 chr11:119252534-11925261 1.0000 80 chr2:196933396-196933476 1.0000 80 chr7:99069249-99069329 1.0000 80 chr11:64646448-64646528 1.0000 80 chr17:34958062-34958142 1.0000 80 chrX:54556876-54556956 1.0000 80 chr1:179335125-179335205 1.0000 80 chr6:10838635-10838715 1.0000 80 chr15:69706451-69706531 1.0000 80 chr14:20801234-20801314 1.0000 80 chr7:123174534-123174614 1.0000 80 chr19:8008926-8009006 1.0000 80 chr11:71159758-71159838 1.0000 80 chr16:81110663-81110743 1.0000 80 chr3:33759220-33759300 1.0000 80 chr19:41903160-41903240 1.0000 80 chr16:58549271-58549351 1.0000 80 chr1:229761128-229761208 1.0000 80 chr17:75317046-75317126 1.0000 80 chr16:4784796-4784876 1.0000 80 chr3:14444804-14444884 1.0000 80 chr1:86173969-86174049 1.0000 80 chr19:18547794-18547874 1.0000 80 chr17:62075785-62075865 1.0000 80 chr12:131324049-13132412 1.0000 80 chr15:64648599-64648679 1.0000 80 chr12:64615929-64616009 1.0000 80 chr4:140222694-140222774 1.0000 80 chr2:223520610-223520690 1.0000 80 chr19:2151855-2151935 1.0000 80 chr16:75145050-75145130 1.0000 80 chr9:127623641-127623721 1.0000 80 chr15:78730118-78730198 1.0000 80 chr1:26633008-26633088 1.0000 80 chr17:44269100-44269180 1.0000 80 chr10:25304961-25305041 1.0000 80 chr11:108535835-10853591 1.0000 80 chr9:34329083-34329163 1.0000 80 chr2:9695535-9695615 1.0000 80 chr16:23464567-23464647 1.0000 80 chr14:96000714-96000794 1.0000 80 chr19:3185337-3185417 1.0000 80 chr11:123612279-12361235 1.0000 80 chr8:30891483-30891563 1.0000 80 chr6:109704178-109704258 1.0000 80 chr16:21964110-21964190 1.0000 80 chr19:36980081-36980161 1.0000 80 chr12:6677305-6677385 1.0000 80 chr11:101785812-10178589 1.0000 80 chr6:7910125-7910205 1.0000 80 chr2:85766980-85767060 1.0000 80 chr4:184427555-184427635 1.0000 80 chr3:167814051-167814131 1.0000 80 chr5:110428225-110428305 1.0000 80 chr16:30441137-30441217 1.0000 80 chr3:52720128-52720208 1.0000 80 chr2:230787279-230787359 1.0000 80 chr9:135545241-135545321 1.0000 80 chr11:59328595-59328675 1.0000 80 chr7:105162011-105162091 1.0000 80 chr19:30433726-30433806 1.0000 80 chr17:1933438-1933518 1.0000 80 chr6:33167685-33167765 1.0000 80 chr17:8152672-8152752 1.0000 80 chr6:33385768-33385848 1.0000 80 chr19:40324563-40324643 1.0000 80 chr12:122243964-12224404 1.0000 80 chr19:5686970-5687050 1.0000 80 chr6:33291256-33291336 1.0000 80 chr6:80714460-80714540 1.0000 80 chr3:47822794-47822874 1.0000 80 chr17:17208892-17208972 1.0000 80 chr19:10426566-10426646 1.0000 80 chr4:113557927-113558007 1.0000 80 chr5:176739179-176739259 1.0000 80 chr19:47852677-47852757 1.0000 80 chr12:56211923-56212003 1.0000 80 chr15:40861510-40861590 1.0000 80 chrX:38186648-38186728 1.0000 80 chr1:11863395-11863475 1.0000 80 chr21:37432413-37432493 1.0000 80 chr19:56826724-56826804 1.0000 80 chr16:53469509-53469589 1.0000 80 chr1:26798443-26798523 1.0000 80 chr19:47289515-47289595 1.0000 80 chr19:34895592-34895672 1.0000 80 chr22:26908373-26908453 1.0000 80 chr16:3018948-3019028 1.0000 80 chr17:33469236-33469316 1.0000 80 chr2:183989548-183989628 1.0000 80 chr6:43543308-43543388 1.0000 80 chr7:137686427-137686507 1.0000 80 chr12:7080127-7080207 1.0000 80 chr7:112580287-112580367 1.0000 80 chr11:71640153-71640233 1.0000 80 chr2:85830033-85830113 1.0000 80 chr6:170862820-170862900 1.0000 80 chr4:54232141-54232221 1.0000 80 chr11:134094264-13409434 1.0000 80 chr2:232328510-232328590 1.0000 80 chr10:14920355-14920435 1.0000 80 chr5:139780307-139780387 1.0000 80 chr1:44435739-44435819 1.0000 80 chr19:1490531-1490611 1.0000 80 chr12:62654801-62654881 1.0000 80 chr11:20409370-20409450 1.0000 80 chr15:41836333-41836413 1.0000 80 chr19:48673420-48673500 1.0000 80 chr7:116657142-116657222 1.0000 80 chr22:51221976-51222056 1.0000 80 chr19:40950497-40950577 1.0000 80 chr1:117603145-117603225 1.0000 80 chr19:50180720-50180800 1.0000 80 chr19:12807330-12807410 1.0000 80 chr7:100887727-100887807 1.0000 80 chr12:132413821-13241390 1.0000 80 chr1:6454141-6454221 1.0000 80 chr20:33264746-33264826 1.0000 80 chr7:44645984-44646064 1.0000 80 chr4:99849315-99849395 1.0000 80 chr12:49463566-49463646 1.0000 80 chr17:41176861-41176941 1.0000 80 chr22:30987844-30987924 1.0000 80 chr4:57301564-57301644 1.0000 80 chr5:68530478-68530558 1.0000 80 chr22:42078252-42078332 1.0000 80 chr14:20923429-20923509 1.0000 80 chr7:102715096-102715176 1.0000 80 chr16:89284130-89284210 1.0000 80 chr8:37888428-37888508 1.0000 80 chr12:12966328-12966408 1.0000 80 chr4:8430323-8430403 1.0000 80 chr12:49717088-49717168 1.0000 80 chr10:104001607-10400168 1.0000 80 chr16:50100004-50100084 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_NKRF/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/NKRF.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.198 C 0.301 G 0.317 T 0.184 Background letter frequencies (from file dataset with add-one prior applied): A 0.198 C 0.301 G 0.317 T 0.184 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF VCACGTGS MEME-1 width = 8 sites = 40 llr = 335 E-value = 1.3e-008 ******************************************************************************** -------------------------------------------------------------------------------- Motif VCACGTGS MEME-1 Description -------------------------------------------------------------------------------- Simplified A 3:a::::1 pos.-specific C 5a:a:::3 probability G 3:::a:a5 matrix T :::::a:1 bits 2.4 * * 2.2 * * 2.0 * * 1.7 ****** Relative 1.5 ****** Entropy 1.2 ****** (12.1 bits) 1.0 ****** 0.7 ****** 0.5 ****** 0.2 ******** 0.0 -------- Multilevel CCACGTGG consensus A C sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VCACGTGS MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr17:33469236-33469316 68 3.16e-05 TCCTGCGTCC CCACGTGG AGGAG chr12:122243964-12224404 25 3.16e-05 GCAACATTAT CCACGTGG AGCTGGACAC chr6:109704178-109704258 59 3.16e-05 AATGGAGGCA CCACGTGG TTAAGGAGTT chr19:2151855-2151935 35 3.16e-05 GGCGGGGCGC CCACGTGG AGCTTAGCCG chr9:127963008-127963088 56 3.16e-05 CCTAGAACTG CCACGTGG GGATGAGATT chr12:125473557-12547363 73 3.16e-05 GAAACCCAGC CCACGTGG chr2:43822834-43822914 29 3.16e-05 GATTTCTGAA CCACGTGG AGTCGAGGAA chr10:104474507-10447458 62 3.16e-05 CCTGCAGAAG CCACGTGG CGCGAAGTGC chr3:49966997-49967077 20 3.16e-05 TGCCTCCAGG CCACGTGG GCTGGCAGTC chr4:54232141-54232221 71 5.25e-05 TCTCCACAGT ACACGTGG TC chr2:183989548-183989628 71 5.25e-05 TGACCGCGGT ACACGTGG GT chr7:105162011-105162091 26 5.25e-05 CAGGGGTGGA ACACGTGG GCTGGACCCA chr5:110428225-110428305 13 5.25e-05 ACGACATTCC ACACGTGG TGCGGTTCAG chrX:54556876-54556956 36 5.25e-05 GGATCGCGGC ACACGTGG AGACGCGCCG chr22:19166624-19166704 14 5.25e-05 CTCCCCGAAA ACACGTGG GGCTAGCCCA chr10:14920355-14920435 14 8.25e-05 CCAGCCATGC CCACGTGC AGCCGCTTCC chr11:64646448-64646528 57 8.25e-05 CCGCCGTTCG CCACGTGC GGTCCTCCAG chr4:57302528-57302608 28 8.25e-05 GAGCTCGCGG CCACGTGC GAGCCGCGAA chr8:144025195-144025275 52 8.25e-05 CCTGTAATGC CCACGTGC ATGTCCATTC chr15:41407808-41407888 58 8.25e-05 CCACCGGGTC CCACGTGC ACCTGGTCTA chr17:49336707-49336787 23 8.25e-05 ATTTCCACCT CCACGTGC AAACCGCCTC chr3:167814051-167814131 38 1.16e-04 CGTTCGGAAC GCACGTGG AGAGCGGAGT chr6:7910125-7910205 28 1.16e-04 TCTGGTGAGT GCACGTGG CCCACGGGCA chr19:36980081-36980161 62 1.16e-04 ACACAATGCC GCACGTGG TCCTGCTCCC chr19:55691502-55691582 53 1.16e-04 CCCACCCCCT GCACGTGG GCGGTGGCGC chr1:44445593-44445673 50 1.16e-04 GGGAATGTCT GCACGTGG GTCTGGGTGT chr15:68522419-68522499 43 1.16e-04 GCGTGGTGCA GCACGTGG GTTGCAGATG chr1:117603145-117603225 7 1.36e-04 GGGCAG ACACGTGC AGCTTCGTGC chr9:127623641-127623721 9 1.36e-04 CCCGATGC ACACGTGC TCCCCACCCA chr21:46961655-46961735 67 1.36e-04 TCCCGAAGCA ACACGTGC CTGGGC chr6:86351702-86351782 34 1.36e-04 CCCATTAGAA ACACGTGC TCTGCGCCTT chr2:232328510-232328590 52 1.54e-04 CCGGGGCCCA CCACGTGT CGGCTTGCCA chr1:33501798-33501878 52 1.54e-04 TCACTCTGCC CCACGTGT TGGAGATGCT chr17:44269100-44269180 48 1.74e-04 TGATTGCTAG CCACGTGA CAAAGGAGAT chr11:65624492-65624572 7 1.74e-04 AGCCGG CCACGTGA CTCGGCCGCA chr22:30987844-30987924 34 2.17e-04 ACTTCCTCCC GCACGTGC CCTGCCAAGG chr12:64174100-64174180 61 2.17e-04 CGCCTTTCAA ACACGTGT TAAAATCCAA chr1:6454141-6454221 58 2.50e-04 GCCTGGAGGT GCACGTGT TGCAGTGAGG chr12:101673930-10167401 3 2.71e-04 CC GCACGTGA GAAAGTCTGG chr7:150759591-150759671 69 2.71e-04 GCCCAGAGGG GCACGTGA CTGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VCACGTGS MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr17:33469236-33469316 3.2e-05 67_[+1]_5 chr12:122243964-12224404 3.2e-05 24_[+1]_48 chr6:109704178-109704258 3.2e-05 58_[+1]_14 chr19:2151855-2151935 3.2e-05 34_[+1]_38 chr9:127963008-127963088 3.2e-05 55_[+1]_17 chr12:125473557-12547363 3.2e-05 72_[+1] chr2:43822834-43822914 3.2e-05 28_[+1]_44 chr10:104474507-10447458 3.2e-05 61_[+1]_11 chr3:49966997-49967077 3.2e-05 19_[+1]_53 chr4:54232141-54232221 5.2e-05 70_[+1]_2 chr2:183989548-183989628 5.2e-05 70_[+1]_2 chr7:105162011-105162091 5.2e-05 25_[+1]_47 chr5:110428225-110428305 5.2e-05 12_[+1]_60 chrX:54556876-54556956 5.2e-05 35_[+1]_37 chr22:19166624-19166704 5.2e-05 13_[+1]_59 chr10:14920355-14920435 8.3e-05 13_[+1]_59 chr11:64646448-64646528 8.3e-05 56_[+1]_16 chr4:57302528-57302608 8.3e-05 27_[+1]_45 chr8:144025195-144025275 8.3e-05 51_[+1]_21 chr15:41407808-41407888 8.3e-05 57_[+1]_15 chr17:49336707-49336787 8.3e-05 22_[+1]_50 chr3:167814051-167814131 0.00012 37_[+1]_35 chr6:7910125-7910205 0.00012 27_[+1]_45 chr19:36980081-36980161 0.00012 61_[+1]_11 chr19:55691502-55691582 0.00012 52_[+1]_20 chr1:44445593-44445673 0.00012 49_[+1]_23 chr15:68522419-68522499 0.00012 42_[+1]_30 chr1:117603145-117603225 0.00014 6_[+1]_66 chr9:127623641-127623721 0.00014 8_[+1]_64 chr21:46961655-46961735 0.00014 66_[+1]_6 chr6:86351702-86351782 0.00014 33_[+1]_39 chr2:232328510-232328590 0.00015 51_[+1]_21 chr1:33501798-33501878 0.00015 51_[+1]_21 chr17:44269100-44269180 0.00017 47_[+1]_25 chr11:65624492-65624572 0.00017 6_[+1]_66 chr22:30987844-30987924 0.00022 33_[+1]_39 chr12:64174100-64174180 0.00022 60_[+1]_12 chr1:6454141-6454221 0.00025 57_[+1]_15 chr12:101673930-10167401 0.00027 2_[+1]_70 chr7:150759591-150759671 0.00027 68_[+1]_4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VCACGTGS MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF VCACGTGS width=8 seqs=40 chr17:33469236-33469316 ( 68) CCACGTGG 1 chr12:122243964-12224404 ( 25) CCACGTGG 1 chr6:109704178-109704258 ( 59) CCACGTGG 1 chr19:2151855-2151935 ( 35) CCACGTGG 1 chr9:127963008-127963088 ( 56) CCACGTGG 1 chr12:125473557-12547363 ( 73) CCACGTGG 1 chr2:43822834-43822914 ( 29) CCACGTGG 1 chr10:104474507-10447458 ( 62) CCACGTGG 1 chr3:49966997-49967077 ( 20) CCACGTGG 1 chr4:54232141-54232221 ( 71) ACACGTGG 1 chr2:183989548-183989628 ( 71) ACACGTGG 1 chr7:105162011-105162091 ( 26) ACACGTGG 1 chr5:110428225-110428305 ( 13) ACACGTGG 1 chrX:54556876-54556956 ( 36) ACACGTGG 1 chr22:19166624-19166704 ( 14) ACACGTGG 1 chr10:14920355-14920435 ( 14) CCACGTGC 1 chr11:64646448-64646528 ( 57) CCACGTGC 1 chr4:57302528-57302608 ( 28) CCACGTGC 1 chr8:144025195-144025275 ( 52) CCACGTGC 1 chr15:41407808-41407888 ( 58) CCACGTGC 1 chr17:49336707-49336787 ( 23) CCACGTGC 1 chr3:167814051-167814131 ( 38) GCACGTGG 1 chr6:7910125-7910205 ( 28) GCACGTGG 1 chr19:36980081-36980161 ( 62) GCACGTGG 1 chr19:55691502-55691582 ( 53) GCACGTGG 1 chr1:44445593-44445673 ( 50) GCACGTGG 1 chr15:68522419-68522499 ( 43) GCACGTGG 1 chr1:117603145-117603225 ( 7) ACACGTGC 1 chr9:127623641-127623721 ( 9) ACACGTGC 1 chr21:46961655-46961735 ( 67) ACACGTGC 1 chr6:86351702-86351782 ( 34) ACACGTGC 1 chr2:232328510-232328590 ( 52) CCACGTGT 1 chr1:33501798-33501878 ( 52) CCACGTGT 1 chr17:44269100-44269180 ( 48) CCACGTGA 1 chr11:65624492-65624572 ( 7) CCACGTGA 1 chr22:30987844-30987924 ( 34) GCACGTGC 1 chr12:64174100-64174180 ( 61) ACACGTGT 1 chr1:6454141-6454221 ( 58) GCACGTGT 1 chr12:101673930-10167401 ( 3) GCACGTGA 1 chr7:150759591-150759671 ( 69) GCACGTGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VCACGTGS MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.77545 E= 1.3e-008 47 66 -34 -1197 -1197 173 -1197 -1197 233 -1197 -1197 -1197 -1197 173 -1197 -1197 -1197 -1197 166 -1197 -1197 -1197 -1197 244 -1197 -1197 166 -1197 -99 -13 73 -88 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VCACGTGS MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 40 E= 1.3e-008 0.275000 0.475000 0.250000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.100000 0.275000 0.525000 0.100000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VCACGTGS MEME-1 regular expression -------------------------------------------------------------------------------- [CAG]CACGTG[GC] -------------------------------------------------------------------------------- Time 4.99 secs. ******************************************************************************** ******************************************************************************** MOTIF WCTCTCCT MEME-2 width = 8 sites = 10 llr = 102 E-value = 3.2e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif WCTCTCCT MEME-2 Description -------------------------------------------------------------------------------- Simplified A 4:::3::: pos.-specific C :a:a:aa: probability G :::::::: matrix T 6:a:7::a bits 2.4 * * 2.2 * * 2.0 * * 1.7 *** *** Relative 1.5 ******** Entropy 1.2 ******** (14.8 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TCTCTCCT consensus A A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCTCTCCT MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:230787279-230787359 71 9.41e-06 CGGTTTACCC TCTCTCCT AA chr10:25304961-25305041 27 9.41e-06 GACCACAGGT TCTCTCCT TCACATCGTC chr2:198570144-198570224 40 9.41e-06 TAGTAGGCTG TCTCTCCT GGAGGACTTC chr8:144025195-144025275 68 9.41e-06 GCATGTCCAT TCTCTCCT GGAAT chr4:57301564-57301644 13 1.95e-05 TGCGTGGGCC ACTCTCCT GAGGCGATGC chr2:32853241-32853321 37 1.95e-05 GCGCCTTTGG ACTCTCCT GTTTTCACTT chr15:75742912-75742992 30 1.95e-05 CCATGCTCCC ACTCTCCT GGCTGCACGG chr9:34329083-34329163 15 2.97e-05 CCCCGCCCTT TCTCACCT CGGTCCAAAC chr2:196933396-196933476 19 2.97e-05 AGAGCAGCCC TCTCACCT GCTCACTGCT chr3:49966997-49967077 39 4.06e-05 CTGGCAGTCA ACTCACCT GTTTCTCAGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCTCTCCT MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:230787279-230787359 9.4e-06 70_[+2]_2 chr10:25304961-25305041 9.4e-06 26_[+2]_46 chr2:198570144-198570224 9.4e-06 39_[+2]_33 chr8:144025195-144025275 9.4e-06 67_[+2]_5 chr4:57301564-57301644 2e-05 12_[+2]_60 chr2:32853241-32853321 2e-05 36_[+2]_36 chr15:75742912-75742992 2e-05 29_[+2]_43 chr9:34329083-34329163 3e-05 14_[+2]_58 chr2:196933396-196933476 3e-05 18_[+2]_54 chr3:49966997-49967077 4.1e-05 38_[+2]_34 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCTCTCCT MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF WCTCTCCT width=8 seqs=10 chr2:230787279-230787359 ( 71) TCTCTCCT 1 chr10:25304961-25305041 ( 27) TCTCTCCT 1 chr2:198570144-198570224 ( 40) TCTCTCCT 1 chr8:144025195-144025275 ( 68) TCTCTCCT 1 chr4:57301564-57301644 ( 13) ACTCTCCT 1 chr2:32853241-32853321 ( 37) ACTCTCCT 1 chr15:75742912-75742992 ( 30) ACTCTCCT 1 chr9:34329083-34329163 ( 15) TCTCACCT 1 chr2:196933396-196933476 ( 19) TCTCACCT 1 chr3:49966997-49967077 ( 39) ACTCACCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCTCTCCT MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.7767 E= 3.2e+003 101 -997 -997 171 -997 173 -997 -997 -997 -997 -997 244 -997 173 -997 -997 60 -997 -997 193 -997 173 -997 -997 -997 173 -997 -997 -997 -997 -997 244 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCTCTCCT MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 10 E= 3.2e+003 0.400000 0.000000 0.000000 0.600000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.300000 0.000000 0.000000 0.700000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCTCTCCT MEME-2 regular expression -------------------------------------------------------------------------------- [TA]CTC[TA]CCT -------------------------------------------------------------------------------- Time 8.73 secs. ******************************************************************************** ******************************************************************************** MOTIF TTSCYYTT MEME-3 width = 8 sites = 31 llr = 254 E-value = 3.0e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTSCYYTT MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::111:: pos.-specific C ::6854:2 probability G ::4:1::: matrix T aa:145a8 bits 2.4 ** * 2.2 ** * 2.0 ** * 1.7 ** * Relative 1.5 ** ** Entropy 1.2 ** ** (11.8 bits) 1.0 ** * *** 0.7 **** *** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTCCCTTT consensus G TC C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTSCYYTT MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:112580287-112580367 72 9.27e-06 CACATGTAGG TTCCCTTT A chr12:53400901-53400981 21 9.27e-06 AGGTTGTCTC TTCCCTTT CTAGAGTGTG chr7:116151810-116151890 24 1.30e-05 CAAAGGAAAG TTGCTTTT GTCTTACTGA chrX:54556876-54556956 56 1.90e-05 ACGCGCCGAA TTGCCTTT TCGCGGAGTG chr6:20401553-20401633 22 1.90e-05 ATGGTCCAAC TTGCCTTT GGCACGTATC chr8:37888428-37888508 21 2.48e-05 CCCCGTTTGT TTCCTCTT TCTGTTAGGT chr21:33765199-33765279 1 2.48e-05 . TTCCTCTT GGGGACCCCC chr19:41903160-41903240 25 4.01e-05 CTGGACCCTG TTCCATTT TCAGCACGGA chr14:20923429-20923509 15 4.97e-05 AGATACGGGG TTGCTCTT TTGCTCATAA chr12:131324049-13132412 55 4.97e-05 ATGCCGAACC TTCTCTTT AAGGGTCCAC chr11:59328595-59328675 27 6.77e-05 AAATGTCACC TTCCTTTC AACTCCTTTC chr2:223520610-223520690 55 6.77e-05 TGTCGCCACA TTGCCCTT TTGGAGGGAG chr9:131133696-131133776 54 6.77e-05 GGGCCCAGAA TTCCTTTC CTTCTGCCGT chr5:175815504-175815584 17 6.77e-05 CCTCCGGGTT TTGCCCTT GGCCTTGGGC chr2:32853241-32853321 48 8.31e-05 CTCTCCTGTT TTCACTTT CTTTTGTTGA chr15:85143748-85143828 65 8.31e-05 CCCCCATGGA TTCCCTTC CTGCCCAG chr6:33256883-33256963 15 9.08e-05 GGTCTGAAGT TTGTCTTT CTTGGGCGGG chr11:107436315-10743639 53 9.43e-05 TGCGTGTGCC TTCTTCTT TGCCAGCCTC chr22:42078252-42078332 7 1.19e-04 TCCTCC TTCCGTTT TTTTACAGCT chr2:85830033-85830113 19 1.19e-04 TGACTAGAGG TTCCGTTT AACCGATTCC chr6:109704178-109704258 6 1.19e-04 GAAGA TTGATTTT GCTAGAAGTT chr8:30891483-30891563 17 1.19e-04 GTAAAGTGTC TTCCTATT CCCGTTTTCC chr14:102771344-10277142 40 1.19e-04 TCCCCCTGCT TTCCACTT CCCTGAGGCG chr16:11350354-11350434 21 1.19e-04 CTACCTCGGG TTCCACTT TCTGCCGCCA chr7:102715096-102715176 69 1.25e-04 AGGAATGTAG TTCTCCTT GAAG chr4:8430323-8430403 22 1.45e-04 CCGGGCACTC TTGCCTTC TCTGCTTTTA chr19:1490531-1490611 43 1.45e-04 AGCCTCAGTT TTCCCATT TGTACAACGA chr19:3185337-3185417 69 1.45e-04 acaaaagttt ttgccttc gtgg chr4:57301564-57301644 47 1.58e-04 ACACGCCACA TTCCTCTC GGATCCCCAA chr12:101673930-10167401 58 1.85e-04 GTGAGCCGCT TTCCCCTC CTTACTGTCG chr4:7044568-7044648 12 2.57e-04 AGAGCTGGCC TTGATCTT GGACGGCCGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTSCYYTT MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:112580287-112580367 9.3e-06 71_[+3]_1 chr12:53400901-53400981 9.3e-06 20_[+3]_52 chr7:116151810-116151890 1.3e-05 23_[+3]_49 chrX:54556876-54556956 1.9e-05 55_[+3]_17 chr6:20401553-20401633 1.9e-05 21_[+3]_51 chr8:37888428-37888508 2.5e-05 20_[+3]_52 chr21:33765199-33765279 2.5e-05 [+3]_72 chr19:41903160-41903240 4e-05 24_[+3]_48 chr14:20923429-20923509 5e-05 14_[+3]_58 chr12:131324049-13132412 5e-05 54_[+3]_18 chr11:59328595-59328675 6.8e-05 26_[+3]_46 chr2:223520610-223520690 6.8e-05 54_[+3]_18 chr9:131133696-131133776 6.8e-05 53_[+3]_19 chr5:175815504-175815584 6.8e-05 16_[+3]_56 chr2:32853241-32853321 8.3e-05 47_[+3]_25 chr15:85143748-85143828 8.3e-05 64_[+3]_8 chr6:33256883-33256963 9.1e-05 14_[+3]_58 chr11:107436315-10743639 9.4e-05 52_[+3]_20 chr22:42078252-42078332 0.00012 6_[+3]_66 chr2:85830033-85830113 0.00012 18_[+3]_54 chr6:109704178-109704258 0.00012 5_[+3]_67 chr8:30891483-30891563 0.00012 16_[+3]_56 chr14:102771344-10277142 0.00012 39_[+3]_33 chr16:11350354-11350434 0.00012 20_[+3]_52 chr7:102715096-102715176 0.00012 68_[+3]_4 chr4:8430323-8430403 0.00014 21_[+3]_51 chr19:1490531-1490611 0.00014 42_[+3]_30 chr19:3185337-3185417 0.00014 68_[+3]_4 chr4:57301564-57301644 0.00016 46_[+3]_26 chr12:101673930-10167401 0.00019 57_[+3]_15 chr4:7044568-7044648 0.00026 11_[+3]_61 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTSCYYTT MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTSCYYTT width=8 seqs=31 chr7:112580287-112580367 ( 72) TTCCCTTT 1 chr12:53400901-53400981 ( 21) TTCCCTTT 1 chr7:116151810-116151890 ( 24) TTGCTTTT 1 chrX:54556876-54556956 ( 56) TTGCCTTT 1 chr6:20401553-20401633 ( 22) TTGCCTTT 1 chr8:37888428-37888508 ( 21) TTCCTCTT 1 chr21:33765199-33765279 ( 1) TTCCTCTT 1 chr19:41903160-41903240 ( 25) TTCCATTT 1 chr14:20923429-20923509 ( 15) TTGCTCTT 1 chr12:131324049-13132412 ( 55) TTCTCTTT 1 chr11:59328595-59328675 ( 27) TTCCTTTC 1 chr2:223520610-223520690 ( 55) TTGCCCTT 1 chr9:131133696-131133776 ( 54) TTCCTTTC 1 chr5:175815504-175815584 ( 17) TTGCCCTT 1 chr2:32853241-32853321 ( 48) TTCACTTT 1 chr15:85143748-85143828 ( 65) TTCCCTTC 1 chr6:33256883-33256963 ( 15) TTGTCTTT 1 chr11:107436315-10743639 ( 53) TTCTTCTT 1 chr22:42078252-42078332 ( 7) TTCCGTTT 1 chr2:85830033-85830113 ( 19) TTCCGTTT 1 chr6:109704178-109704258 ( 6) TTGATTTT 1 chr8:30891483-30891563 ( 17) TTCCTATT 1 chr14:102771344-10277142 ( 40) TTCCACTT 1 chr16:11350354-11350434 ( 21) TTCCACTT 1 chr7:102715096-102715176 ( 69) TTCTCCTT 1 chr4:8430323-8430403 ( 22) TTGCCTTC 1 chr19:1490531-1490611 ( 43) TTCCCATT 1 chr19:3185337-3185417 ( 69) TTGCCTTC 1 chr4:57301564-57301644 ( 47) TTCCTCTC 1 chr12:101673930-10167401 ( 58) TTCCCCTC 1 chr4:7044568-7044648 ( 12) TTGATCTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTSCYYTT MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.4993 E= 3.0e+003 -1160 -1160 -1160 244 -1160 -1160 -1160 244 -1160 110 16 -1160 -103 136 -1160 -51 -103 68 -229 95 -162 36 -1160 158 -1160 -1160 -1160 244 -1160 -42 -1160 207 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTSCYYTT MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 31 E= 3.0e+003 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.645161 0.354839 0.000000 0.096774 0.774194 0.000000 0.129032 0.096774 0.483871 0.064516 0.354839 0.064516 0.387097 0.000000 0.548387 0.000000 0.000000 0.000000 1.000000 0.000000 0.225806 0.000000 0.774194 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTSCYYTT MEME-3 regular expression -------------------------------------------------------------------------------- TT[CG]C[CT][TC]T[TC] -------------------------------------------------------------------------------- Time 12.44 secs. ******************************************************************************** ******************************************************************************** MOTIF TTTTCTGA MEME-4 width = 8 sites = 2 llr = 25 E-value = 2.0e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTTTCTGA MEME-4 Description -------------------------------------------------------------------------------- Simplified A :::::::a pos.-specific C ::::a::: probability G ::::::a: matrix T aaaa:a:: bits 2.4 **** * * 2.2 **** * * 2.0 **** * * 1.7 ******** Relative 1.5 ******** Entropy 1.2 ******** (17.9 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTTTCTGA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTTCTGA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:42078252-42078332 24 3.98e-06 TTTTTACAGC TTTTCTGA CACAGCGGGA chr7:65580500-65580580 61 3.98e-06 GGGTAAAAGA TTTTCTGA CAGTTTAACT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTTCTGA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:42078252-42078332 4e-06 23_[+4]_49 chr7:65580500-65580580 4e-06 60_[+4]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTTCTGA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTTTCTGA width=8 seqs=2 chr22:42078252-42078332 ( 24) TTTTCTGA 1 chr7:65580500-65580580 ( 61) TTTTCTGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTTCTGA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 13.1555 E= 2.0e+004 -765 -765 -765 244 -765 -765 -765 244 -765 -765 -765 244 -765 -765 -765 244 -765 173 -765 -765 -765 -765 -765 244 -765 -765 165 -765 233 -765 -765 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTTCTGA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 2.0e+004 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTTCTGA MEME-4 regular expression -------------------------------------------------------------------------------- TTTTCTGA -------------------------------------------------------------------------------- Time 16.11 secs. ******************************************************************************** ******************************************************************************** MOTIF BCTSCAGC MEME-5 width = 8 sites = 23 llr = 203 E-value = 1.3e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif BCTSCAGC MEME-5 Description -------------------------------------------------------------------------------- Simplified A :::::a:: pos.-specific C 4a:6a::a probability G 3::4::a: matrix T 3:a::::: bits 2.4 * * 2.2 * * 2.0 * * 1.7 ** **** Relative 1.5 ** **** Entropy 1.2 ** **** (12.7 bits) 1.0 ** **** 0.7 ******* 0.5 ******* 0.2 ******** 0.0 -------- Multilevel CCTCCAGC consensus G G sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif BCTSCAGC MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr4:57301564-57301644 67 4.60e-05 ATCCCCAACT CCTCCAGC TCCATG chr15:41836333-41836413 64 4.60e-05 GAAATCCGTC CCTCCAGC CCCGCCACC chr10:14920355-14920435 1 4.60e-05 . TCTCCAGC CATGCCCACG chr7:137686427-137686507 9 4.60e-05 CTCCCCGC TCTCCAGC ACCTCCATGG chr1:26798443-26798523 71 4.60e-05 GCAGCCTGTG CCTCCAGC CG chr12:64615929-64616009 31 4.60e-05 GAGAAGAACG TCTCCAGC ACCGCCTGTT chr15:69706451-69706531 51 4.60e-05 tcaagatctc cctccagc cctgacaCGC chr11:64646448-64646528 68 4.60e-05 CACGTGCGGT CCTCCAGC TGGCT chr19:41109650-41109730 11 4.60e-05 CGCACAGCTG TCTCCAGC TGTTCTCTGC chr15:41708905-41708985 23 4.60e-05 GGGTCGGCAG TCTCCAGC CCCCAACCGG chr7:44645984-44646064 53 7.60e-05 AAACAGCTGG GCTCCAGC TGGCCCTGGC chr1:26633008-26633088 22 7.60e-05 CGGGGCTCGG GCTCCAGC CTGCGTGGGG chr17:30228556-30228636 30 7.60e-05 AGTCCAATGC GCTCCAGC TGTTCCAATT chr12:125473557-12547363 33 7.60e-05 CAGGGTGGGC GCTCCAGC GGCCGGACCA chr1:6454141-6454221 16 1.24e-04 TACACCGCCG CCTGCAGC TTTTACTGGG chr16:58549271-58549351 56 1.24e-04 CTCCGGCCAG TCTGCAGC GTGGACGACA chr6:10838635-10838715 58 1.24e-04 GGGTGGTGGC CCTGCAGC CCGCTGGGGA chr3:12526178-12526258 52 1.24e-04 TCCTCGTGCG CCTGCAGC CCTTGGTTCT chr4:57302528-57302608 61 1.24e-04 GTCCCGCCTC CCTGCAGC AGCGCCTCTA chr15:85524017-85524097 64 1.24e-04 AGGACGGGCG CCTGCAGC CTGCCCGGT chr3:52720128-52720208 42 1.56e-04 TCTGGAAGTT GCTGCAGC CACCACGACG chr12:50506033-50506113 38 1.56e-04 ATGCGAAGGA GCTGCAGC ATCCAGGTAC chr10:104474507-10447458 28 1.56e-04 CCCAGGCGGG GCTGCAGC GCGGGCTGGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif BCTSCAGC MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:57301564-57301644 4.6e-05 66_[+5]_6 chr15:41836333-41836413 4.6e-05 63_[+5]_9 chr10:14920355-14920435 4.6e-05 [+5]_72 chr7:137686427-137686507 4.6e-05 8_[+5]_64 chr1:26798443-26798523 4.6e-05 70_[+5]_2 chr12:64615929-64616009 4.6e-05 30_[+5]_42 chr15:69706451-69706531 4.6e-05 50_[+5]_22 chr11:64646448-64646528 4.6e-05 67_[+5]_5 chr19:41109650-41109730 4.6e-05 10_[+5]_62 chr15:41708905-41708985 4.6e-05 22_[+5]_50 chr7:44645984-44646064 7.6e-05 52_[+5]_20 chr1:26633008-26633088 7.6e-05 21_[+5]_51 chr17:30228556-30228636 7.6e-05 29_[+5]_43 chr12:125473557-12547363 7.6e-05 32_[+5]_40 chr1:6454141-6454221 0.00012 15_[+5]_57 chr16:58549271-58549351 0.00012 55_[+5]_17 chr6:10838635-10838715 0.00012 57_[+5]_15 chr3:12526178-12526258 0.00012 51_[+5]_21 chr4:57302528-57302608 0.00012 60_[+5]_12 chr15:85524017-85524097 0.00012 63_[+5]_9 chr3:52720128-52720208 0.00016 41_[+5]_31 chr12:50506033-50506113 0.00016 37_[+5]_35 chr10:104474507-10447458 0.00016 27_[+5]_45 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif BCTSCAGC MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF BCTSCAGC width=8 seqs=23 chr4:57301564-57301644 ( 67) CCTCCAGC 1 chr15:41836333-41836413 ( 64) CCTCCAGC 1 chr10:14920355-14920435 ( 1) TCTCCAGC 1 chr7:137686427-137686507 ( 9) TCTCCAGC 1 chr1:26798443-26798523 ( 71) CCTCCAGC 1 chr12:64615929-64616009 ( 31) TCTCCAGC 1 chr15:69706451-69706531 ( 51) CCTCCAGC 1 chr11:64646448-64646528 ( 68) CCTCCAGC 1 chr19:41109650-41109730 ( 11) TCTCCAGC 1 chr15:41708905-41708985 ( 23) TCTCCAGC 1 chr7:44645984-44646064 ( 53) GCTCCAGC 1 chr1:26633008-26633088 ( 22) GCTCCAGC 1 chr17:30228556-30228636 ( 30) GCTCCAGC 1 chr12:125473557-12547363 ( 33) GCTCCAGC 1 chr1:6454141-6454221 ( 16) CCTGCAGC 1 chr16:58549271-58549351 ( 56) TCTGCAGC 1 chr6:10838635-10838715 ( 58) CCTGCAGC 1 chr3:12526178-12526258 ( 52) CCTGCAGC 1 chr4:57302528-57302608 ( 61) CCTGCAGC 1 chr15:85524017-85524097 ( 64) CCTGCAGC 1 chr3:52720128-52720208 ( 42) GCTGCAGC 1 chr12:50506033-50506113 ( 38) GCTGCAGC 1 chr10:104474507-10447458 ( 28) GCTGCAGC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif BCTSCAGC MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.0332 E= 1.3e+002 -1117 53 -6 51 -1117 173 -1117 -1117 -1117 -1117 -1117 244 -1117 101 31 -1117 -1117 173 -1117 -1117 233 -1117 -1117 -1117 -1117 -1117 166 -1117 -1117 173 -1117 -1117 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif BCTSCAGC MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 23 E= 1.3e+002 0.000000 0.434783 0.304348 0.260870 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.608696 0.391304 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif BCTSCAGC MEME-5 regular expression -------------------------------------------------------------------------------- [CGT]CT[CG]CAGC -------------------------------------------------------------------------------- Time 19.78 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:44078860-44078940 9.90e-01 80 chr17:25853699-25853779 6.84e-03 80 chr3:49966997-49967077 4.00e-05 19_[+1(3.16e-05)]_11_[+2(4.06e-05)]_\ 34 chr16:30773239-30773319 9.41e-01 80 chr3:20083055-20083135 8.84e-01 80 chr19:54666231-54666311 9.97e-01 80 chr15:85524017-85524097 3.08e-02 80 chr16:72042742-72042822 8.73e-01 80 chr4:81256969-81257049 2.15e-01 80 chr17:49336707-49336787 3.55e-02 22_[+1(8.25e-05)]_50 chr6:7312706-7312786 8.24e-01 80 chr22:31460142-31460222 9.51e-01 80 chr8:117778981-117779061 8.73e-01 80 chr11:113185414-11318549 9.22e-01 80 chr16:29624187-29624267 4.00e-01 80 chrX:152735420-152735500 9.48e-03 80 chr21:33765199-33765279 1.58e-02 [+3(2.48e-05)]_72 chr15:41708905-41708985 1.70e-02 22_[+5(4.60e-05)]_50 chr1:156251121-156251201 5.10e-01 80 chr16:4784597-4784677 9.04e-01 80 chr20:44859589-44859669 1.00e+00 80 chr6:20401553-20401633 8.57e-04 21_[+3(1.90e-05)]_51 chr1:100435869-100435949 6.38e-01 80 chr10:104474507-10447458 2.20e-04 61_[+1(3.16e-05)]_11 chr15:68522419-68522499 7.76e-02 80 chr2:170684874-170684954 4.44e-01 80 chr10:99160982-99161062 6.99e-01 80 chr15:85143748-85143828 8.78e-02 64_[+3(8.31e-05)]_8 chr5:175815504-175815584 7.70e-02 16_[+3(6.77e-05)]_56 chr4:110736962-110737042 6.93e-01 80 chr6:86351702-86351782 4.50e-02 80 chr10:26986915-26986995 8.17e-01 80 chr15:41407808-41407888 1.13e-01 57_[+1(8.25e-05)]_15 chr19:50321046-50321126 6.86e-01 80 chr7:65580500-65580580 5.04e-02 60_[+4(3.98e-06)]_12 chr8:144025195-144025275 2.70e-04 51_[+1(8.25e-05)]_8_[+2(9.41e-06)]_\ 5 chr12:53400901-53400981 2.43e-03 20_[+3(9.27e-06)]_52 chr2:43822834-43822914 7.07e-03 28_[+1(3.16e-05)]_44 chr12:125473557-12547363 2.40e-03 32_[+5(7.60e-05)]_32_[+1(3.16e-05)] chr21:46961655-46961735 3.10e-01 80 chr4:7044568-7044648 2.98e-01 80 chr2:68385086-68385166 9.70e-01 80 chr20:3190247-3190327 1.00e+00 80 chr19:49631626-49631706 6.77e-01 80 chr19:1864287-1864367 9.85e-02 80 chr14:73393246-73393326 5.49e-01 80 chr6:33256883-33256963 3.52e-03 14_[+3(9.08e-05)]_58 chr19:13002060-13002140 7.87e-01 80 chr16:11350354-11350434 3.52e-03 80 chr5:72861599-72861679 4.29e-01 80 chr11:65624492-65624572 3.56e-01 80 chr2:88991394-88991474 8.84e-01 80 chr3:194392772-194392852 3.95e-01 80 chr9:132020896-132020976 5.88e-01 80 chr12:105380170-10538025 9.08e-01 80 chr8:95908075-95908155 5.35e-01 80 chr4:57302528-57302608 8.71e-03 27_[+1(8.25e-05)]_45 chr10:75911056-75911136 9.97e-01 80 chr9:131133696-131133776 1.33e-02 53_[+3(6.77e-05)]_19 chr2:198570144-198570224 1.61e-02 39_[+2(9.41e-06)]_33 chr20:30467623-30467703 9.48e-01 80 chr10:102747364-10274744 8.84e-01 80 chr16:30418628-30418708 9.42e-01 80 chr22:32058090-32058170 2.45e-01 80 chr7:150759591-150759671 2.59e-01 80 chr7:116151810-116151890 3.64e-03 [+3(3.63e-05)]_15_[+3(1.30e-05)]_49 chr12:64174100-64174180 1.71e-01 80 chr9:4793043-4793123 1.05e-01 80 chr9:131218098-131218178 5.41e-01 80 chr1:245026161-245026241 6.10e-01 80 chr7:75072189-75072269 9.10e-01 80 chr14:102771344-10277142 4.80e-02 80 chr8:144416858-144416938 3.62e-01 80 chr12:100594383-10059446 6.42e-01 80 chr2:131967130-131967210 3.40e-01 80 chr17:79980503-79980583 2.95e-01 80 chr16:69166570-69166650 9.99e-01 80 chr9:111696840-111696920 3.74e-01 80 chr11:66057117-66057197 9.08e-02 80 chr6:5261333-5261413 7.92e-01 80 chr19:17690771-17690851 8.36e-01 80 chr3:12526178-12526258 4.31e-03 80 chr17:30228556-30228636 5.49e-03 29_[+5(7.60e-05)]_43 chr1:44445593-44445673 1.09e-01 80 chr15:75742912-75742992 5.21e-02 29_[+2(1.95e-05)]_43 chr1:145826901-145826981 4.01e-01 80 chr1:156542244-156542324 9.85e-03 80 chr22:19166624-19166704 6.00e-02 13_[+1(5.25e-05)]_59 chr17:4458484-4458564 8.78e-01 80 chr17:73285226-73285306 5.42e-02 80 chr16:56485506-56485586 9.57e-01 80 chr20:20033222-20033302 9.64e-01 80 chr12:109535658-10953573 5.89e-01 80 chr8:92082643-92082723 9.94e-01 80 chr19:59085108-59085188 9.99e-01 80 chr19:45682121-45682201 5.77e-02 80 chr2:32853241-32853321 3.53e-04 36_[+2(1.95e-05)]_3_[+3(8.31e-05)]_\ 25 chr19:55691502-55691582 1.36e-01 80 chr9:127963008-127963088 5.57e-03 55_[+1(3.16e-05)]_17 chr9:33473825-33473905 5.60e-02 80 chr3:51975859-51975939 1.14e-01 80 chr19:1605704-1605784 6.35e-01 80 chr7:100450048-100450128 5.25e-01 80 chr12:50506033-50506113 3.44e-01 80 chr12:101673930-10167401 1.58e-02 80 chr11:107436315-10743639 1.54e-02 52_[+3(9.43e-05)]_20 chr1:33501798-33501878 6.10e-03 80 chr3:195869986-195870066 9.31e-01 80 chr12:110841326-11084140 5.16e-02 80 chr5:137514806-137514886 3.73e-01 80 chr21:34100684-34100764 6.53e-01 80 chr19:41109650-41109730 1.24e-02 10_[+5(4.60e-05)]_62 chr1:230562399-230562479 6.88e-02 80 chr17:71088772-71088852 2.23e-01 80 chr5:180229492-180229572 5.03e-01 80 chr11:119252534-11925261 9.65e-01 80 chr2:196933396-196933476 7.80e-02 18_[+2(2.97e-05)]_54 chr7:99069249-99069329 1.87e-01 80 chr11:64646448-64646528 2.42e-03 56_[+1(8.25e-05)]_3_[+5(4.60e-05)]_\ 5 chr17:34958062-34958142 7.19e-01 80 chrX:54556876-54556956 1.84e-03 35_[+1(5.25e-05)]_12_[+3(1.90e-05)]_\ 17 chr1:179335125-179335205 6.33e-01 80 chr6:10838635-10838715 3.71e-01 80 chr15:69706451-69706531 2.25e-02 50_[+5(4.60e-05)]_22 chr14:20801234-20801314 1.45e-01 80 chr7:123174534-123174614 1.79e-01 80 chr19:8008926-8009006 1.03e-01 80 chr11:71159758-71159838 1.38e-01 80 chr16:81110663-81110743 2.88e-01 80 chr3:33759220-33759300 9.09e-01 80 chr19:41903160-41903240 1.02e-03 24_[+3(4.01e-05)]_48 chr16:58549271-58549351 3.57e-02 80 chr1:229761128-229761208 6.62e-01 80 chr17:75317046-75317126 2.30e-01 80 chr16:4784796-4784876 7.40e-01 80 chr3:14444804-14444884 5.31e-01 80 chr1:86173969-86174049 4.90e-02 80 chr19:18547794-18547874 8.03e-01 80 chr17:62075785-62075865 9.89e-01 80 chr12:131324049-13132412 1.15e-02 54_[+3(4.97e-05)]_18 chr15:64648599-64648679 5.13e-02 80 chr12:64615929-64616009 1.06e-01 30_[+5(4.60e-05)]_42 chr4:140222694-140222774 7.90e-01 80 chr2:223520610-223520690 6.27e-02 54_[+3(6.77e-05)]_18 chr19:2151855-2151935 7.61e-02 34_[+1(3.16e-05)]_38 chr16:75145050-75145130 3.93e-01 80 chr9:127623641-127623721 1.05e-01 80 chr15:78730118-78730198 8.56e-01 80 chr1:26633008-26633088 6.31e-02 21_[+5(7.60e-05)]_51 chr17:44269100-44269180 2.77e-01 80 chr10:25304961-25305041 2.30e-03 26_[+2(9.41e-06)]_46 chr11:108535835-10853591 4.72e-01 80 chr9:34329083-34329163 2.02e-02 14_[+2(2.97e-05)]_58 chr2:9695535-9695615 5.44e-02 80 chr16:23464567-23464647 9.43e-01 80 chr14:96000714-96000794 9.13e-01 80 chr19:3185337-3185417 1.55e-01 80 chr11:123612279-12361235 1.27e-01 80 chr8:30891483-30891563 2.81e-02 80 chr6:109704178-109704258 2.92e-03 58_[+1(3.16e-05)]_14 chr16:21964110-21964190 8.71e-01 80 chr19:36980081-36980161 1.62e-01 80 chr12:6677305-6677385 5.85e-02 80 chr11:101785812-10178589 7.40e-01 80 chr6:7910125-7910205 1.04e-01 80 chr2:85766980-85767060 4.05e-01 80 chr4:184427555-184427635 5.63e-01 80 chr3:167814051-167814131 4.36e-02 80 chr5:110428225-110428305 2.12e-02 12_[+1(5.25e-05)]_60 chr16:30441137-30441217 3.55e-01 80 chr3:52720128-52720208 2.42e-02 80 chr2:230787279-230787359 6.06e-03 70_[+2(9.41e-06)]_2 chr9:135545241-135545321 3.87e-01 80 chr11:59328595-59328675 2.42e-02 26_[+3(6.77e-05)]_46 chr7:105162011-105162091 2.85e-01 25_[+1(5.25e-05)]_47 chr19:30433726-30433806 5.28e-02 80 chr17:1933438-1933518 8.62e-01 80 chr6:33167685-33167765 9.12e-01 80 chr17:8152672-8152752 5.14e-02 80 chr6:33385768-33385848 2.41e-01 80 chr19:40324563-40324643 6.92e-01 80 chr12:122243964-12224404 1.52e-01 24_[+1(3.16e-05)]_48 chr19:5686970-5687050 3.06e-01 80 chr6:33291256-33291336 1.22e-01 80 chr6:80714460-80714540 7.51e-01 80 chr3:47822794-47822874 5.29e-01 80 chr17:17208892-17208972 5.36e-02 80 chr19:10426566-10426646 3.52e-01 80 chr4:113557927-113558007 1.90e-01 80 chr5:176739179-176739259 4.68e-02 80 chr19:47852677-47852757 9.85e-01 80 chr12:56211923-56212003 9.97e-01 80 chr15:40861510-40861590 8.31e-01 80 chrX:38186648-38186728 9.08e-01 80 chr1:11863395-11863475 5.23e-01 80 chr21:37432413-37432493 1.29e-01 80 chr19:56826724-56826804 3.77e-01 80 chr16:53469509-53469589 5.93e-02 80 chr1:26798443-26798523 4.95e-03 70_[+5(4.60e-05)]_2 chr19:47289515-47289595 6.79e-02 80 chr19:34895592-34895672 3.09e-01 80 chr22:26908373-26908453 1.69e-01 80 chr16:3018948-3019028 7.80e-01 80 chr17:33469236-33469316 7.35e-02 67_[+1(3.16e-05)]_5 chr2:183989548-183989628 8.19e-02 70_[+1(5.25e-05)]_2 chr6:43543308-43543388 9.89e-01 80 chr7:137686427-137686507 1.28e-01 8_[+5(4.60e-05)]_64 chr12:7080127-7080207 9.29e-01 80 chr7:112580287-112580367 1.42e-03 71_[+3(9.27e-06)]_1 chr11:71640153-71640233 9.85e-01 80 chr2:85830033-85830113 8.13e-02 80 chr6:170862820-170862900 8.92e-01 80 chr4:54232141-54232221 6.69e-03 70_[+1(5.25e-05)]_2 chr11:134094264-13409434 8.33e-01 80 chr2:232328510-232328590 3.56e-01 80 chr10:14920355-14920435 7.41e-03 [+5(4.60e-05)]_5_[+1(8.25e-05)]_59 chr5:139780307-139780387 6.08e-02 80 chr1:44435739-44435819 8.07e-01 80 chr19:1490531-1490611 2.32e-02 80 chr12:62654801-62654881 4.30e-01 80 chr11:20409370-20409450 8.16e-01 80 chr15:41836333-41836413 5.88e-02 63_[+5(4.60e-05)]_9 chr19:48673420-48673500 3.16e-01 80 chr7:116657142-116657222 2.15e-02 80 chr22:51221976-51222056 7.71e-01 80 chr19:40950497-40950577 2.46e-01 80 chr1:117603145-117603225 1.33e-01 80 chr19:50180720-50180800 5.58e-01 80 chr19:12807330-12807410 5.52e-01 80 chr7:100887727-100887807 3.03e-01 80 chr12:132413821-13241390 5.05e-01 80 chr1:6454141-6454221 6.05e-03 80 chr20:33264746-33264826 3.83e-02 80 chr7:44645984-44646064 5.19e-02 52_[+5(7.60e-05)]_20 chr4:99849315-99849395 8.78e-01 80 chr12:49463566-49463646 9.93e-01 80 chr17:41176861-41176941 2.85e-01 80 chr22:30987844-30987924 5.12e-02 80 chr4:57301564-57301644 2.34e-05 12_[+2(1.95e-05)]_46_[+5(4.60e-05)]_\ 6 chr5:68530478-68530558 9.77e-01 80 chr22:42078252-42078332 7.21e-04 23_[+4(3.98e-06)]_49 chr14:20923429-20923509 2.36e-02 14_[+3(4.97e-05)]_58 chr7:102715096-102715176 4.00e-02 80 chr16:89284130-89284210 7.66e-01 80 chr8:37888428-37888508 1.31e-03 20_[+3(2.48e-05)]_52 chr12:12966328-12966408 9.39e-01 80 chr4:8430323-8430403 5.86e-03 80 chr12:49717088-49717168 9.72e-01 80 chr10:104001607-10400168 5.58e-01 80 chr16:50100004-50100084 4.59e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n05.farnam.hpc.yale.internal ********************************************************************************