******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/HNRNPH1.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr5:42730811-42730891 1.0000 80 chr9:126031136-126031216 1.0000 80 chr10:97416526-97416606 1.0000 80 chr4:56483261-56483341 1.0000 80 chr3:119813415-119813495 1.0000 80 chr2:149402921-149403001 1.0000 80 chr14:95623791-95623871 1.0000 80 chr7:92205253-92205333 1.0000 80 chr11:61447780-61447860 1.0000 80 chr17:30688438-30688518 1.0000 80 chr2:196521864-196521944 1.0000 80 chr11:64053169-64053249 1.0000 80 chr1:186327627-186327707 1.0000 80 chr17:56404226-56404306 1.0000 80 chr3:142505222-142505302 1.0000 80 chr1:186330501-186330581 1.0000 80 chr3:169482812-169482892 1.0000 80 chr13:91076829-91076909 1.0000 80 chr19:10224887-10224967 1.0000 80 chr1:186331746-186331826 1.0000 80 chr12:112512490-11251257 1.0000 80 chr12:125406276-12540635 1.0000 80 chr12:123810093-12381017 1.0000 80 chr10:70513321-70513401 1.0000 80 chr21:46494599-46494679 1.0000 80 chr5:84624211-84624291 1.0000 80 chr21:46494947-46495027 1.0000 80 chr1:28837167-28837247 1.0000 80 chr11:65269477-65269557 1.0000 80 chr7:35840722-35840802 1.0000 80 chr1:186315221-186315301 1.0000 80 chr18:22937073-22937153 1.0000 80 chr17:74732617-74732697 1.0000 80 chr7:120768792-120768872 1.0000 80 chr17:7476405-7476485 1.0000 80 chr11:65190900-65190980 1.0000 80 chr2:232328548-232328628 1.0000 80 chr6:34360466-34360546 1.0000 80 chr9:103361120-103361200 1.0000 80 chr1:156286875-156286955 1.0000 80 chr8:99956634-99956714 1.0000 80 chr3:75765902-75765982 1.0000 80 chr22:38902429-38902509 1.0000 80 chr16:9185515-9185595 1.0000 80 chr1:186305766-186305846 1.0000 80 chr21:46494196-46494276 1.0000 80 chr4:166248482-166248562 1.0000 80 chr5:37324386-37324466 1.0000 80 chr6:28703182-28703262 1.0000 80 chr8:145739405-145739485 1.0000 80 chr20:62328192-62328272 1.0000 80 chr6:16129413-16129493 1.0000 80 chr22:41842712-41842792 1.0000 80 chr21:33041990-33042070 1.0000 80 chr17:56407823-56407903 1.0000 80 chr1:236750871-236750951 1.0000 80 chr1:26232363-26232443 1.0000 80 chr7:44836603-44836683 1.0000 80 chr7:135283799-135283879 1.0000 80 chrX:41193826-41193906 1.0000 80 chr9:130829531-130829611 1.0000 80 chr6:34204480-34204560 1.0000 80 chr11:65190701-65190781 1.0000 80 chr5:170815512-170815592 1.0000 80 chr1:26232602-26232682 1.0000 80 chr10:49824815-49824895 1.0000 80 chr10:70513539-70513619 1.0000 80 chr1:186295128-186295208 1.0000 80 chr1:28836876-28836956 1.0000 80 chr7:26240456-26240536 1.0000 80 chr18:2771817-2771897 1.0000 80 chr17:25414773-25414853 1.0000 80 chr13:92287130-92287210 1.0000 80 chr6:30689270-30689350 1.0000 80 chr13:91376285-91376365 1.0000 80 chr10:70516096-70516176 1.0000 80 chr3:186501871-186501951 1.0000 80 chr11:10830610-10830690 1.0000 80 chr6:34203574-34203654 1.0000 80 chr18:23616611-23616691 1.0000 80 chr5:176873595-176873675 1.0000 80 chr4:73654270-73654350 1.0000 80 chr17:7145693-7145773 1.0000 80 chr1:27561013-27561093 1.0000 80 chr21:45284491-45284571 1.0000 80 chr7:148823313-148823393 1.0000 80 chr13:93320058-93320138 1.0000 80 chr1:116915832-116915912 1.0000 80 chr6:74230176-74230256 1.0000 80 chr7:82536220-82536300 1.0000 80 chr7:135278888-135278968 1.0000 80 chr11:65274293-65274373 1.0000 80 chr1:144534211-144534291 1.0000 80 chr17:56408584-56408664 1.0000 80 chr13:91602190-91602270 1.0000 80 chr17:79479461-79479541 1.0000 80 chr2:178077860-178077940 1.0000 80 chr17:62223485-62223565 1.0000 80 chr3:47459687-47459767 1.0000 80 chr2:121832771-121832851 1.0000 80 chr1:205718721-205718801 1.0000 80 chr17:56407466-56407546 1.0000 80 chr10:70738077-70738157 1.0000 80 chr3:75761475-75761555 1.0000 80 chr1:78469981-78470061 1.0000 80 chr6:44215193-44215273 1.0000 80 chr6:147632625-147632705 1.0000 80 chr1:45187319-45187399 1.0000 80 chr8:54887787-54887867 1.0000 80 chr1:109642858-109642938 1.0000 80 chr3:9438296-9438376 1.0000 80 chr10:87245150-87245230 1.0000 80 chr1:186307021-186307101 1.0000 80 chr5:137802145-137802225 1.0000 80 chr7:5569342-5569422 1.0000 80 chr18:9925801-9925881 1.0000 80 chr3:195808911-195808991 1.0000 80 chr17:56736316-56736396 1.0000 80 chr17:56408821-56408901 1.0000 80 chr20:47904169-47904249 1.0000 80 chr12:46122878-46122958 1.0000 80 chr4:54291927-54292007 1.0000 80 chr19:10226603-10226683 1.0000 80 chr1:31628261-31628341 1.0000 80 chr6:26055622-26055702 1.0000 80 chr1:186297574-186297654 1.0000 80 chr16:31191899-31191979 1.0000 80 chr10:70721227-70721307 1.0000 80 chr11:65625052-65625132 1.0000 80 chr20:62328424-62328504 1.0000 80 chr1:175970051-175970131 1.0000 80 chr12:123465329-12346540 1.0000 80 chr11:62432805-62432885 1.0000 80 chr17:56756807-56756887 1.0000 80 chr6:26160001-26160081 1.0000 80 chr7:135300253-135300333 1.0000 80 chr1:245026525-245026605 1.0000 80 chr1:45196466-45196546 1.0000 80 chr12:110719407-11071948 1.0000 80 chr11:65274492-65274572 1.0000 80 chr2:170667920-170668000 1.0000 80 chr4:39780906-39780986 1.0000 80 chr11:65666925-65667005 1.0000 80 chr6:26123396-26123476 1.0000 80 chr21:30433064-30433144 1.0000 80 chr1:236757449-236757529 1.0000 80 chr21:30439772-30439852 1.0000 80 chr17:39834694-39834774 1.0000 80 chr5:56111284-56111364 1.0000 80 chr17:39845559-39845639 1.0000 80 chr16:18812830-18812910 1.0000 80 chr13:91044375-91044455 1.0000 80 chr17:62223685-62223765 1.0000 80 chr13:91044095-91044175 1.0000 80 chr15:60771183-60771263 1.0000 80 chr6:28726079-28726159 1.0000 80 chr11:95614038-95614118 1.0000 80 chr5:179126088-179126168 1.0000 80 chr11:93474368-93474448 1.0000 80 chr8:48774409-48774489 1.0000 80 chr19:15490304-15490384 1.0000 80 chr16:29817096-29817176 1.0000 80 chr19:18682800-18682880 1.0000 80 chr2:190649056-190649136 1.0000 80 chr21:46494399-46494479 1.0000 80 chr11:118350703-11835078 1.0000 80 chr5:176873952-176874032 1.0000 80 chr8:66754286-66754366 1.0000 80 chr1:19496276-19496356 1.0000 80 chr3:9438608-9438688 1.0000 80 chr9:91926412-91926492 1.0000 80 chr19:13208381-13208461 1.0000 80 chr19:55919097-55919177 1.0000 80 chr8:144897998-144898078 1.0000 80 chr1:17231840-17231920 1.0000 80 chr11:64009199-64009279 1.0000 80 chr19:52073667-52073747 1.0000 80 chr6:41863154-41863234 1.0000 80 chr17:43226078-43226158 1.0000 80 chr5:145531206-145531286 1.0000 80 chr20:60962322-60962402 1.0000 80 chr6:31802756-31802836 1.0000 80 chr1:145105716-145105796 1.0000 80 chr7:141251354-141251434 1.0000 80 chr19:50180628-50180708 1.0000 80 chr17:62501684-62501764 1.0000 80 chr17:79679538-79679618 1.0000 80 chr7:111101559-111101639 1.0000 80 chr12:76478113-76478193 1.0000 80 chr10:70721014-70721094 1.0000 80 chr1:186325393-186325473 1.0000 80 chr5:145551038-145551118 1.0000 80 chr1:147735953-147736033 1.0000 80 chr21:30432782-30432862 1.0000 80 chr22:22848230-22848310 1.0000 80 chr6:33244892-33244972 1.0000 80 chr17:73775438-73775518 1.0000 80 chr12:120729326-12072940 1.0000 80 chr21:38469087-38469167 1.0000 80 chr6:111196884-111196964 1.0000 80 chr6:27862834-27862914 1.0000 80 chr21:30440007-30440087 1.0000 80 chr1:52706113-52706193 1.0000 80 chr6:28626026-28626106 1.0000 80 chr7:148581855-148581935 1.0000 80 chr7:103796963-103797043 1.0000 80 chr7:120766476-120766556 1.0000 80 chr1:245006482-245006562 1.0000 80 chr1:148241508-148241588 1.0000 80 chr10:70727412-70727492 1.0000 80 chr17:30694524-30694604 1.0000 80 chr16:70575247-70575327 1.0000 80 chr12:48081105-48081185 1.0000 80 chr6:119513457-119513537 1.0000 80 chr7:108538402-108538482 1.0000 80 chr18:20153233-20153313 1.0000 80 chr3:149687920-149688000 1.0000 80 chr1:186328558-186328638 1.0000 80 chr13:92116346-92116426 1.0000 80 chr7:136084420-136084500 1.0000 80 chr7:111202318-111202398 1.0000 80 chr3:142502375-142502455 1.0000 80 chr7:103213988-103214068 1.0000 80 chr7:100026358-100026438 1.0000 80 chr7:135302804-135302884 1.0000 80 chr6:158981309-158981389 1.0000 80 chr11:72533271-72533351 1.0000 80 chr1:247094861-247094941 1.0000 80 chr8:146012621-146012701 1.0000 80 chr11:118965647-11896572 1.0000 80 chr19:17008710-17008790 1.0000 80 chr12:121647912-12164799 1.0000 80 chr1:22055047-22055127 1.0000 80 chr3:75761810-75761890 1.0000 80 chr5:145531497-145531577 1.0000 80 chr13:91611226-91611306 1.0000 80 chr7:119317897-119317977 1.0000 80 chr3:185543684-185543764 1.0000 80 chr1:186330721-186330801 1.0000 80 chr6:119513157-119513237 1.0000 80 chr5:81573169-81573249 1.0000 80 chr17:39845761-39845841 1.0000 80 chr11:34111706-34111786 1.0000 80 chr4:184365630-184365710 1.0000 80 chr18:23616813-23616893 1.0000 80 chr4:146025742-146025822 1.0000 80 chr1:206808693-206808773 1.0000 80 chr5:145862982-145863062 1.0000 80 chr11:5262702-5262782 1.0000 80 chr11:46259452-46259532 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_HNRNPH1/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/HNRNPH1.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.238 C 0.266 G 0.265 T 0.231 Background letter frequencies (from file dataset with add-one prior applied): A 0.238 C 0.266 G 0.265 T 0.231 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF WDTATTTT MEME-1 width = 8 sites = 45 llr = 377 E-value = 3.5e-013 ******************************************************************************** -------------------------------------------------------------------------------- Motif WDTATTTT MEME-1 Description -------------------------------------------------------------------------------- Simplified A 4429:::: pos.-specific C 1::::::: probability G :21::::: matrix T 546:aaaa bits 2.1 **** 1.9 **** 1.7 **** 1.5 ***** Relative 1.3 ***** Entropy 1.1 ***** (12.1 bits) 0.8 ****** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TATATTTT consensus ATA sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WDTATTTT MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:103213988-103214068 46 8.35e-06 AAAAAGCAGT TTTATTTT AGGTGTGCTA chr1:236757449-236757529 2 8.35e-06 A TTTATTTT GCAAGCTAAC chr4:54291927-54292007 1 8.35e-06 . TTTATTTT AAAATTTATT chr10:70516096-70516176 18 8.35e-06 AGACAGTGGT TTTATTTT TCCCGGATGT chr5:145862982-145863062 70 1.70e-05 TTATGACCTT TATATTTT TAG chr7:119317897-119317977 30 1.70e-05 TTTGGAGTCT TATATTTT CACTTTTACT chr1:186297574-186297654 13 1.70e-05 aaatctgatg tatatttt atatttgtat chr7:135278888-135278968 14 1.70e-05 TGTATATCTC TATATTTT TTTTTGAGAA chr5:37324386-37324466 54 1.70e-05 attactttta tatatttt tgtatagtca chr7:136084420-136084500 55 2.56e-05 ACTCATGTAA ATTATTTT AAATGGGCAG chr1:186328558-186328638 56 2.56e-05 TTACACAGAG ATTATTTT AATTTGAAGA chr21:38469087-38469167 67 2.56e-05 tatgttaagc attatttt aagtgc chr1:145105716-145105796 58 2.56e-05 TATTATTAAT ATTATTTT AAGGGACCTG chr10:70721227-70721307 13 2.56e-05 atatgcatct attatttt taatcagatt chr16:70575247-70575327 10 3.44e-05 cgatttgca aatatttt ctctcatttt chr13:91044375-91044455 36 3.44e-05 GGTCAGGGAA AATATTTT AAAATGAGTA chr6:26160001-26160081 61 3.44e-05 AAGCCTGAGT AATATTTT CTAAATTCTT chr22:38902429-38902509 26 4.40e-05 CGACGATGGG TGTATTTT GCGGTCTGTA chr1:186330501-186330581 54 4.40e-05 CCCTGCTGTC TGTATTTT CAAAAATATA chr7:135300253-135300333 4 5.26e-05 AGT TTAATTTT TCTTATGTAT chr7:82536220-82536300 54 5.26e-05 TGTTCTCTGC TTAATTTT GACATTATAT chr7:135283799-135283879 29 5.26e-05 TATATCATCC TTAATTTT GTTGCCAAAG chr11:95614038-95614118 55 6.15e-05 ataaagttgg taaatttt agcacaatca chr21:30432782-30432862 45 7.14e-05 TATGCAAATG AGTATTTT TAAAGATCAA chr1:17231840-17231920 8 7.14e-05 aagaaaa agtatttt cctgtacttg chr18:23616813-23616893 14 8.94e-05 ttttgtaaat aaaatttt attggaatac chr6:26055622-26055702 30 8.94e-05 GGGACTTTTG AAAATTTT TTAGTCCAAT chr18:22937073-22937153 16 8.94e-05 TTATAACCCC AAAATTTT AAGTTTTTGT chr17:56736316-56736396 5 9.90e-05 ctgg cttatttt tccacccttc chr1:78469981-78470061 53 9.90e-05 AAGTCCTTTA CTTATTTT AAAATAACGC chr7:120766476-120766556 9 1.09e-04 TCCCCCAA CATATTTT GTTTTTCCTC chr1:116915832-116915912 1 1.09e-04 . CATATTTT AGGAAGTGAg chr3:142502375-142502455 36 1.28e-04 tggaactttg tgaatttt ttcttccaaa chr10:70738077-70738157 52 1.28e-04 tttcaaatgg tgaatttt gtggtatgtg chr1:186331746-186331826 70 1.28e-04 ACGCAATTGG TTGATTTT TTA chr17:30688438-30688518 24 1.28e-04 CAGTTAGATT TTGATTTT GTCATACATT chr21:30439772-30439852 27 1.58e-04 tactatAATA ATGATTTT AGTTTATGTT chr21:33041990-33042070 59 1.58e-04 ATCTCAGTAG AGAATTTT TAAAAAGCAG chr6:119513157-119513237 60 2.00e-04 TTGTTCTTAA TGGATTTT CCTGTCAATG chr17:56407823-56407903 59 2.00e-04 TGTGCCACAG TGGATTTT GCCCAATTTT chr8:48774409-48774489 29 2.19e-04 CAAGTTCTGA CAAATTTT GTAGTTGCCT chr19:52073667-52073747 26 2.27e-04 tttaaattac tatttttt aaaaaaGAAG chr4:39780906-39780986 46 2.27e-04 ATTTGACACC TATTTTTT AGTGATGAAA chr3:75761810-75761890 33 2.36e-04 aaatatttct tttctttt caaccttctc chr18:9925801-9925881 21 3.16e-04 TCAATTTAAA AATCTTTT TCATATATTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WDTATTTT MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:103213988-103214068 8.4e-06 45_[+1]_27 chr1:236757449-236757529 8.4e-06 1_[+1]_71 chr4:54291927-54292007 8.4e-06 [+1]_72 chr10:70516096-70516176 8.4e-06 17_[+1]_55 chr5:145862982-145863062 1.7e-05 69_[+1]_3 chr7:119317897-119317977 1.7e-05 29_[+1]_43 chr1:186297574-186297654 1.7e-05 12_[+1]_60 chr7:135278888-135278968 1.7e-05 13_[+1]_59 chr5:37324386-37324466 1.7e-05 53_[+1]_19 chr7:136084420-136084500 2.6e-05 54_[+1]_18 chr1:186328558-186328638 2.6e-05 55_[+1]_17 chr21:38469087-38469167 2.6e-05 66_[+1]_6 chr1:145105716-145105796 2.6e-05 57_[+1]_15 chr10:70721227-70721307 2.6e-05 12_[+1]_60 chr16:70575247-70575327 3.4e-05 9_[+1]_63 chr13:91044375-91044455 3.4e-05 35_[+1]_37 chr6:26160001-26160081 3.4e-05 60_[+1]_12 chr22:38902429-38902509 4.4e-05 25_[+1]_47 chr1:186330501-186330581 4.4e-05 53_[+1]_19 chr7:135300253-135300333 5.3e-05 3_[+1]_69 chr7:82536220-82536300 5.3e-05 53_[+1]_19 chr7:135283799-135283879 5.3e-05 28_[+1]_44 chr11:95614038-95614118 6.1e-05 54_[+1]_18 chr21:30432782-30432862 7.1e-05 44_[+1]_28 chr1:17231840-17231920 7.1e-05 7_[+1]_65 chr18:23616813-23616893 8.9e-05 13_[+1]_59 chr6:26055622-26055702 8.9e-05 29_[+1]_43 chr18:22937073-22937153 8.9e-05 15_[+1]_57 chr17:56736316-56736396 9.9e-05 4_[+1]_68 chr1:78469981-78470061 9.9e-05 52_[+1]_20 chr7:120766476-120766556 0.00011 8_[+1]_64 chr1:116915832-116915912 0.00011 [+1]_72 chr3:142502375-142502455 0.00013 35_[+1]_37 chr10:70738077-70738157 0.00013 51_[+1]_21 chr1:186331746-186331826 0.00013 69_[+1]_3 chr17:30688438-30688518 0.00013 23_[+1]_49 chr21:30439772-30439852 0.00016 26_[+1]_46 chr21:33041990-33042070 0.00016 58_[+1]_14 chr6:119513157-119513237 0.0002 59_[+1]_13 chr17:56407823-56407903 0.0002 58_[+1]_14 chr8:48774409-48774489 0.00022 28_[+1]_44 chr19:52073667-52073747 0.00023 25_[+1]_47 chr4:39780906-39780986 0.00023 45_[+1]_27 chr3:75761810-75761890 0.00024 32_[+1]_40 chr18:9925801-9925881 0.00032 20_[+1]_52 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WDTATTTT MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF WDTATTTT width=8 seqs=45 chr7:103213988-103214068 ( 46) TTTATTTT 1 chr1:236757449-236757529 ( 2) TTTATTTT 1 chr4:54291927-54292007 ( 1) TTTATTTT 1 chr10:70516096-70516176 ( 18) TTTATTTT 1 chr5:145862982-145863062 ( 70) TATATTTT 1 chr7:119317897-119317977 ( 30) TATATTTT 1 chr1:186297574-186297654 ( 13) TATATTTT 1 chr7:135278888-135278968 ( 14) TATATTTT 1 chr5:37324386-37324466 ( 54) TATATTTT 1 chr7:136084420-136084500 ( 55) ATTATTTT 1 chr1:186328558-186328638 ( 56) ATTATTTT 1 chr21:38469087-38469167 ( 67) ATTATTTT 1 chr1:145105716-145105796 ( 58) ATTATTTT 1 chr10:70721227-70721307 ( 13) ATTATTTT 1 chr16:70575247-70575327 ( 10) AATATTTT 1 chr13:91044375-91044455 ( 36) AATATTTT 1 chr6:26160001-26160081 ( 61) AATATTTT 1 chr22:38902429-38902509 ( 26) TGTATTTT 1 chr1:186330501-186330581 ( 54) TGTATTTT 1 chr7:135300253-135300333 ( 4) TTAATTTT 1 chr7:82536220-82536300 ( 54) TTAATTTT 1 chr7:135283799-135283879 ( 29) TTAATTTT 1 chr11:95614038-95614118 ( 55) TAAATTTT 1 chr21:30432782-30432862 ( 45) AGTATTTT 1 chr1:17231840-17231920 ( 8) AGTATTTT 1 chr18:23616813-23616893 ( 14) AAAATTTT 1 chr6:26055622-26055702 ( 30) AAAATTTT 1 chr18:22937073-22937153 ( 16) AAAATTTT 1 chr17:56736316-56736396 ( 5) CTTATTTT 1 chr1:78469981-78470061 ( 53) CTTATTTT 1 chr7:120766476-120766556 ( 9) CATATTTT 1 chr1:116915832-116915912 ( 1) CATATTTT 1 chr3:142502375-142502455 ( 36) TGAATTTT 1 chr10:70738077-70738157 ( 52) TGAATTTT 1 chr1:186331746-186331826 ( 70) TTGATTTT 1 chr17:30688438-30688518 ( 24) TTGATTTT 1 chr21:30439772-30439852 ( 27) ATGATTTT 1 chr21:33041990-33042070 ( 59) AGAATTTT 1 chr6:119513157-119513237 ( 60) TGGATTTT 1 chr17:56407823-56407903 ( 59) TGGATTTT 1 chr8:48774409-48774489 ( 29) CAAATTTT 1 chr19:52073667-52073747 ( 26) TATTTTTT 1 chr4:39780906-39780986 ( 46) TATTTTTT 1 chr3:75761810-75761890 ( 33) TTTCTTTT 1 chr18:9925801-9925881 ( 21) AATCTTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WDTATTTT MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.5458 E= 3.5e-013 58 -126 -1214 121 75 -1214 -40 79 4 -1214 -125 148 194 -258 -1214 -237 -1214 -1214 -1214 212 -1214 -1214 -1214 212 -1214 -1214 -1214 212 -1214 -1214 -1214 212 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WDTATTTT MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 45 E= 3.5e-013 0.355556 0.111111 0.000000 0.533333 0.400000 0.000000 0.200000 0.400000 0.244444 0.000000 0.111111 0.644444 0.911111 0.044444 0.000000 0.044444 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WDTATTTT MEME-1 regular expression -------------------------------------------------------------------------------- [TA][ATG][TA]ATTTT -------------------------------------------------------------------------------- Time 5.03 secs. ******************************************************************************** ******************************************************************************** MOTIF AAAATAMA MEME-2 width = 8 sites = 49 llr = 381 E-value = 3.1e-004 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAAATAMA MEME-2 Description -------------------------------------------------------------------------------- Simplified A aaa82957 pos.-specific C ::::2:3: probability G :::::::1 matrix T :::26122 bits 2.1 *** 1.9 *** 1.7 *** 1.5 **** * Relative 1.3 **** * Entropy 1.1 **** * (11.2 bits) 0.8 **** * * 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AAAATAAA consensus C CT sequence A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAMA MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr6:119513457-119513537 17 9.99e-06 GCAATGAGGA AAAATAAA CCTAAAAGAG chr18:20153233-20153313 35 2.12e-05 ttgttttatt aaaataca ttgctagaaa chr5:145551038-145551118 66 2.12e-05 AAAAATGATC AAAATACA ATACAAC chr1:45196466-45196546 5 2.12e-05 tatt aaaataca aaaactaaca chr5:37324386-37324466 16 2.12e-05 aacatacaat aaaataca aatactaaga chr17:30688438-30688518 64 2.12e-05 ATCATCAGAG AAAATACA CCCAGTCAT chr21:30432782-30432862 16 3.09e-05 TAGTTCTGGG AAAATATA CTATTAAACA chr17:25414773-25414853 50 3.09e-05 attcatgcac aaaatata tgaagatctc chr7:108538402-108538482 19 5.27e-05 ATTGAAAGGT AAAACAAA TATTCTTGAT chr5:145531206-145531286 57 5.27e-05 GGACATGATA AAAACAAA AATTAGAAAT chr10:70738077-70738157 19 5.27e-05 taaaacaaac aaaaaaaa cactggatta chr1:186305766-186305846 70 5.27e-05 TCTTTAAAGG AAAACAAA GTA chr22:38902429-38902509 49 5.27e-05 CTGTACAAGA AAAACAAA GTACGGAGCG chr1:186315221-186315301 15 5.27e-05 TTACAAGTTA AAAAAAAA ATTAATACGG chr1:186330501-186330581 29 5.27e-05 TATTAGATAA AAAACAAA CAAAACCCCC chr1:186327627-186327707 25 5.27e-05 TAAAAGTAGG AAAACAAA CAAAAAAATT chr1:186330721-186330801 1 6.24e-05 . AAAATAAT GTTCCCATAA chr7:120766476-120766556 56 6.24e-05 AAAAACataa aaaataat ttattaaatt chr11:95614038-95614118 72 6.24e-05 tagcacaatc aaaataat a chr10:87245150-87245230 20 6.24e-05 atacttagat aaaataat ctgtttgtta chr1:236750871-236750951 39 7.21e-05 ATCCTAGTAC AAATTAAA AGTTTTAAGA chr7:119317897-119317977 70 1.06e-04 GAAGGCTTTA AAAAAACA GTA chr13:91044095-91044175 31 1.06e-04 caaaaagctt aaaaaaca ccaaccagta chr1:236757449-236757529 60 1.06e-04 TTCTCAGAAT AAAACACA CACACTGATA chr5:84624211-84624291 56 1.06e-04 TACCATCTTG AAAACACA CAGAATATTG chr17:56736316-56736396 36 1.17e-04 gaaacggTAT AAAATACT TAGCGAGCAT chr8:54887787-54887867 42 1.17e-04 tgcaaacaac aaaatact ggtaattgtt chr1:19496276-19496356 12 1.28e-04 AAGACAACTG AAAATAAG ATGCAAAGTG chr13:91602190-91602270 28 1.28e-04 ATAATTATAT AAAATAAG ACTAGTTTCT chr10:70513321-70513401 61 1.28e-04 AAAAAGTATC AAAATAAG GATAACACTG chr10:70721014-70721094 52 1.49e-04 tcctgattat aaaaaata tgtgatccag chr1:186307021-186307101 72 1.69e-04 GTAATATTCA AAATTACA A chr13:91611226-91611306 42 2.01e-04 TACAGAGCCA AAAATTCA ATGAGGATAA chr4:56483261-56483341 9 2.01e-04 GGAACTGG AAAAAAAT GGTACTGATT chr1:186325393-186325473 63 2.23e-04 TTGTGACAAT AAAATACG GTACATATCA chr7:135283799-135283879 15 2.23e-04 ATATATGAAG AAATTATA TCATCCTTAA chr7:135302804-135302884 7 2.54e-04 GCAAAG AAATAAAA GAGATGTCAG chr13:91044375-91044455 56 2.54e-04 AATGAGTAGC AAATAAAA TCACAGCCTG chr21:30439772-30439852 68 2.54e-04 TATGTAAGCA AAAATTTA GTAGG chr7:135300253-135300333 32 2.54e-04 TTGTTTTGTG AAATCAAA ACCAAACTAT chr6:26160001-26160081 45 2.54e-04 TTGGACGGAT AAATAAAA GCCTGAGTAA chr4:54291927-54292007 9 2.54e-04 TTTATTTT AAAATTTA TTGCAAACAC chr6:147632625-147632705 44 2.54e-04 AATGGGTAAG AAATAAAA TTTGGTGAGT chr7:92205253-92205333 15 2.54e-04 TATTATTCCG AAAATTTA AGAGAAATAT chr3:75761475-75761555 8 2.84e-04 ctttatg aaaactaa atcaatactt chr5:145862982-145863062 56 3.18e-04 GATTTCAAGC AAAATTAT GACCTTTATA chr7:82536220-82536300 38 3.28e-04 ATGATTCTCA AAAATATG TTCTCTGCTT chr1:245006482-245006562 47 4.06e-04 TCAACCACAT AAAACATT TCATGTGCAA chr1:175970051-175970131 20 4.51e-04 atactatgtc aaaattct gctgcaatat -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAMA MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr6:119513457-119513537 1e-05 16_[+2]_56 chr18:20153233-20153313 2.1e-05 34_[+2]_38 chr5:145551038-145551118 2.1e-05 65_[+2]_7 chr1:45196466-45196546 2.1e-05 4_[+2]_68 chr5:37324386-37324466 2.1e-05 15_[+2]_57 chr17:30688438-30688518 2.1e-05 63_[+2]_9 chr21:30432782-30432862 3.1e-05 15_[+2]_57 chr17:25414773-25414853 3.1e-05 49_[+2]_23 chr7:108538402-108538482 5.3e-05 18_[+2]_54 chr5:145531206-145531286 5.3e-05 56_[+2]_16 chr10:70738077-70738157 5.3e-05 18_[+2]_54 chr1:186305766-186305846 5.3e-05 69_[+2]_3 chr22:38902429-38902509 5.3e-05 48_[+2]_24 chr1:186315221-186315301 5.3e-05 14_[+2]_58 chr1:186330501-186330581 5.3e-05 28_[+2]_44 chr1:186327627-186327707 5.3e-05 24_[+2]_48 chr1:186330721-186330801 6.2e-05 [+2]_72 chr7:120766476-120766556 6.2e-05 55_[+2]_17 chr11:95614038-95614118 6.2e-05 71_[+2]_1 chr10:87245150-87245230 6.2e-05 19_[+2]_53 chr1:236750871-236750951 7.2e-05 38_[+2]_34 chr7:119317897-119317977 0.00011 69_[+2]_3 chr13:91044095-91044175 0.00011 30_[+2]_42 chr1:236757449-236757529 0.00011 59_[+2]_13 chr5:84624211-84624291 0.00011 55_[+2]_17 chr17:56736316-56736396 0.00012 35_[+2]_37 chr8:54887787-54887867 0.00012 41_[+2]_31 chr1:19496276-19496356 0.00013 11_[+2]_61 chr13:91602190-91602270 0.00013 27_[+2]_45 chr10:70513321-70513401 0.00013 60_[+2]_12 chr10:70721014-70721094 0.00015 51_[+2]_21 chr1:186307021-186307101 0.00017 71_[+2]_1 chr13:91611226-91611306 0.0002 41_[+2]_31 chr4:56483261-56483341 0.0002 8_[+2]_64 chr1:186325393-186325473 0.00022 62_[+2]_10 chr7:135283799-135283879 0.00022 14_[+2]_58 chr7:135302804-135302884 0.00025 6_[+2]_66 chr13:91044375-91044455 0.00025 55_[+2]_17 chr21:30439772-30439852 0.00025 67_[+2]_5 chr7:135300253-135300333 0.00025 31_[+2]_41 chr6:26160001-26160081 0.00025 44_[+2]_28 chr4:54291927-54292007 0.00025 8_[+2]_64 chr6:147632625-147632705 0.00025 43_[+2]_29 chr7:92205253-92205333 0.00025 14_[+2]_58 chr3:75761475-75761555 0.00028 7_[+2]_65 chr5:145862982-145863062 0.00032 55_[+2]_17 chr7:82536220-82536300 0.00033 37_[+2]_35 chr1:245006482-245006562 0.00041 46_[+2]_26 chr1:175970051-175970131 0.00045 19_[+2]_53 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAMA MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAAATAMA width=8 seqs=49 chr6:119513457-119513537 ( 17) AAAATAAA 1 chr18:20153233-20153313 ( 35) AAAATACA 1 chr5:145551038-145551118 ( 66) AAAATACA 1 chr1:45196466-45196546 ( 5) AAAATACA 1 chr5:37324386-37324466 ( 16) AAAATACA 1 chr17:30688438-30688518 ( 64) AAAATACA 1 chr21:30432782-30432862 ( 16) AAAATATA 1 chr17:25414773-25414853 ( 50) AAAATATA 1 chr7:108538402-108538482 ( 19) AAAACAAA 1 chr5:145531206-145531286 ( 57) AAAACAAA 1 chr10:70738077-70738157 ( 19) AAAAAAAA 1 chr1:186305766-186305846 ( 70) AAAACAAA 1 chr22:38902429-38902509 ( 49) AAAACAAA 1 chr1:186315221-186315301 ( 15) AAAAAAAA 1 chr1:186330501-186330581 ( 29) AAAACAAA 1 chr1:186327627-186327707 ( 25) AAAACAAA 1 chr1:186330721-186330801 ( 1) AAAATAAT 1 chr7:120766476-120766556 ( 56) AAAATAAT 1 chr11:95614038-95614118 ( 72) AAAATAAT 1 chr10:87245150-87245230 ( 20) AAAATAAT 1 chr1:236750871-236750951 ( 39) AAATTAAA 1 chr7:119317897-119317977 ( 70) AAAAAACA 1 chr13:91044095-91044175 ( 31) AAAAAACA 1 chr1:236757449-236757529 ( 60) AAAACACA 1 chr5:84624211-84624291 ( 56) AAAACACA 1 chr17:56736316-56736396 ( 36) AAAATACT 1 chr8:54887787-54887867 ( 42) AAAATACT 1 chr1:19496276-19496356 ( 12) AAAATAAG 1 chr13:91602190-91602270 ( 28) AAAATAAG 1 chr10:70513321-70513401 ( 61) AAAATAAG 1 chr10:70721014-70721094 ( 52) AAAAAATA 1 chr1:186307021-186307101 ( 72) AAATTACA 1 chr13:91611226-91611306 ( 42) AAAATTCA 1 chr4:56483261-56483341 ( 9) AAAAAAAT 1 chr1:186325393-186325473 ( 63) AAAATACG 1 chr7:135283799-135283879 ( 15) AAATTATA 1 chr7:135302804-135302884 ( 7) AAATAAAA 1 chr13:91044375-91044455 ( 56) AAATAAAA 1 chr21:30439772-30439852 ( 68) AAAATTTA 1 chr7:135300253-135300333 ( 32) AAATCAAA 1 chr6:26160001-26160081 ( 45) AAATAAAA 1 chr4:54291927-54292007 ( 9) AAAATTTA 1 chr6:147632625-147632705 ( 44) AAATAAAA 1 chr7:92205253-92205333 ( 15) AAAATTTA 1 chr3:75761475-75761555 ( 8) AAAACTAA 1 chr5:145862982-145863062 ( 56) AAAATTAT 1 chr7:82536220-82536300 ( 38) AAAATATG 1 chr1:245006482-245006562 ( 47) AAAACATT 1 chr1:175970051-175970131 ( 20) AAAATTCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAMA MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.1364 E= 3.1e-004 207 -1226 -1226 -1226 207 -1226 -1226 -1226 207 -1226 -1226 -1226 181 -1226 -1226 -50 -22 -25 -1226 131 185 -1226 -1226 -69 110 20 -1226 -33 154 -1226 -137 -18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAMA MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 49 E= 3.1e-004 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.836735 0.000000 0.000000 0.163265 0.204082 0.224490 0.000000 0.571429 0.857143 0.000000 0.000000 0.142857 0.510204 0.306122 0.000000 0.183673 0.693878 0.000000 0.102041 0.204082 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAMA MEME-2 regular expression -------------------------------------------------------------------------------- AAAA[TCA]A[AC][AT] -------------------------------------------------------------------------------- Time 8.81 secs. ******************************************************************************** ******************************************************************************** MOTIF SGGCGSSG MEME-3 width = 8 sites = 64 llr = 472 E-value = 7.9e-006 ******************************************************************************** -------------------------------------------------------------------------------- Motif SGGCGSSG MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C 53:a366: probability G 57a:744a matrix T :::::::: bits 2.1 1.9 ** * 1.7 ** * 1.5 ** * Relative 1.3 ** * Entropy 1.1 ***** * (10.6 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GGGCGCCG consensus CC CGG sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SGGCGSSG MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:50180628-50180708 67 2.46e-05 CCGCACACGG GGGCGCCG CACGTT chr11:65666925-65667005 70 2.46e-05 GGCGGGCAGC GGGCGCCG TTA chr7:5569342-5569422 37 2.46e-05 ggccgccagg gggcgccg gcgcgcgccc chr21:46494947-46495027 17 2.46e-05 CCCCTCCCGA GGGCGCCG AGTCCGCGTG chr4:184365630-184365710 56 4.93e-05 GCAGCGGCCC CGGCGCCG CAAAGCGTCT chr6:158981309-158981389 31 4.93e-05 CCCTGGCTCC CGGCGCCG TGCCGCAGGG chr20:60962322-60962402 31 4.93e-05 GCCGTACTCA CGGCGCCG CGCGGTGACT chr5:176873595-176873675 58 4.93e-05 AACCGGGTCT CGGCGCCG CAGGTGGGTG chr21:46494196-46494276 17 4.93e-05 CTCGGGCGGG CGGCGCCG CGACGCCAGG chr12:121647912-12164799 43 9.83e-05 GACTGGGAGC GGGCGGCG CGGCCATGGC chr6:111196884-111196964 29 9.83e-05 TTCTTGCCTC GGGCGCGG ATAGGAGGGG chr12:110719407-11071948 18 9.83e-05 CTGGGGGAGG GGGCGCGG GGTGATTCAG chr12:123465329-12346540 14 9.83e-05 AGGCCGCGAA GGGCGCGG GGCTGGAGGG chr1:31628261-31628341 71 9.83e-05 GGGGCGCAGA GGGCGGCG CC chr12:46122878-46122958 1 9.83e-05 . GGGCGGCG CGCAGCGGCT chr17:7145693-7145773 17 9.83e-05 CCGGGACGGG GGGCGGCG ACGACGGCGG chr6:34203574-34203654 57 9.83e-05 CTCGGGGACC GGGCGCGG GAGGTGCGCC chr11:118965647-11896572 12 1.47e-04 cggccggccg cggcgcgg gcccTCTTAG chr7:141251354-141251434 50 1.47e-04 GTGCAGGCGG CGGCGCGG CTTGAGGGTA chr16:31191899-31191979 62 1.47e-04 TCCCCCTTCG CGGCGCGG GTACCCCTTC chr6:74230176-74230256 39 1.47e-04 GGGCGATACA CGGCGGCG CGAGGCCAGG chr5:170815512-170815592 32 1.47e-04 TGGGGAGGCG CGGCGCGG CGTGAGGAGG chr6:34204480-34204560 54 1.47e-04 gcggcagcgg cggcggcg gctggcgggc chr16:9185515-9185595 50 1.47e-04 cgatcagcgg cggcggcg gcagtgggga chr10:97416526-97416606 26 1.47e-04 CCTGGAGCTG CGGCGCGG CAATGGCGTA chr1:206808693-206808773 73 2.21e-04 TACCGGCCAC GGGCCCCG chr1:247094861-247094941 36 2.21e-04 GGGCGGGTGA GCGCGCCG CCGCGGGCCG chr11:72533271-72533351 25 2.21e-04 AGCGCAAGGC GCGCGCCG CGGCCGAGCG chr17:62501684-62501764 2 2.21e-04 C GGGCGGGG TAACAAAGGC chr21:46494399-46494479 60 2.21e-04 gggccggcgg gggcgggg agggggcgga chr11:93474368-93474448 42 2.21e-04 ACCAACGAAG GGGCCCCG GGAAACCCCA chr11:62432805-62432885 72 2.21e-04 GGAAGGCTCT GGGCGGGG T chr2:178077860-178077940 38 2.21e-04 GCGGCATGGC GGGCCCCG GCGGGAGCGG chr6:30689270-30689350 3 2.21e-04 TT GGGCCCCG CCCCTCGCGC chr8:99956634-99956714 53 2.21e-04 GGAGGGACGC GGGCGGGG ACGGAGCTCG chr9:103361120-103361200 30 2.21e-04 CCCGCAGTAA GCGCGCCG GGGCCGGGGA chr12:76478113-76478193 34 2.95e-04 AAGCGCTGGT CGGCCCCG GGGCCCCTCT chr9:91926412-91926492 48 2.95e-04 GGGTGCCTGG CCGCGCCG GGCCGGTTGG chr8:66754286-66754366 72 2.95e-04 CGTCACGAcg ccgcgccg c chr1:205718721-205718801 10 2.95e-04 CCAAGGGGA CGGCCCCG AGGAGGTGGG chr1:116915832-116915912 41 2.95e-04 gctggagctg cggcgggg tctggggcgc chr17:74732617-74732697 66 2.95e-04 GTCCTCCGCC CCGCGCCG CCCACAC chr21:46494599-46494679 1 2.95e-04 . CCGCGCCG CTGCGCACAA chr7:148581855-148581935 67 3.94e-04 TCGTTTCCCC GCGCGCGG AGCCGA chr17:79679538-79679618 21 3.94e-04 GGTGAGGCCG GGGCCCGG GACGCGGGGC chr6:41863154-41863234 42 3.94e-04 GCGCAGCGCT GGGCCGCG ACCCCGGCAC chr8:144897998-144898078 61 3.94e-04 ggcccgcccc gcgcgcgg gATATTGGGA chr21:45284491-45284571 6 3.94e-04 CCGCC GCGCGGCG ACCCCTGACG chr1:27561013-27561093 2 3.94e-04 G GGGCCCGG CTAGCCATTC chrX:41193826-41193906 72 3.94e-04 GGAGTGCGCA GCGCGGCG G chr1:26232363-26232443 36 3.94e-04 AACCCTCGTG GGGCCCGG GAGCGCCGCC chr19:55919097-55919177 59 4.92e-04 AGCACTGAGC CGGCCGCG CGCGCACCAC chr19:13208381-13208461 4 4.92e-04 CTC CGGCCGCG GGTCTCCCCG chr3:9438608-9438688 37 4.92e-04 CGCAGGAGGC CGGCCGCG CCCGCACACC chr5:176873952-176874032 17 4.92e-04 CCCGTGAGTA CCGCGGCG GCTGCGGGCC chr15:60771183-60771263 27 4.92e-04 ACCTCATGGT CCGCGGCG GCTCTTGCCC chr19:10226603-10226683 66 4.92e-04 CATGGACTCC CCGCGGCG GCTGGCC chr6:44215193-44215273 24 4.92e-04 CACGTGGTGG CCGCGCGG CCCGGGACGC chr9:130829531-130829611 38 4.92e-04 CAGCCCCGAC CGGCCCGG CCGCTGCCAG chr6:34360466-34360546 3 4.92e-04 GA CGGCCGCG CGCTCGCAGC chr17:73775438-73775518 39 5.66e-04 GGGAGGGGGA GCGCGGGG AGGAGTCACT chr11:65190701-65190781 10 5.66e-04 GCTGCAGGA GGGCCGGG AGGGCTAATC chr22:41842712-41842792 73 5.66e-04 GCACCTTCCC GCGCCCCG chr11:65625052-65625132 13 8.11e-04 CGCCCCTCCC GGGCGCAG GCATCCCTGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SGGCGSSG MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:50180628-50180708 2.5e-05 66_[+3]_6 chr11:65666925-65667005 2.5e-05 69_[+3]_3 chr7:5569342-5569422 2.5e-05 36_[+3]_36 chr21:46494947-46495027 2.5e-05 16_[+3]_56 chr4:184365630-184365710 4.9e-05 55_[+3]_17 chr6:158981309-158981389 4.9e-05 30_[+3]_42 chr20:60962322-60962402 4.9e-05 30_[+3]_42 chr5:176873595-176873675 4.9e-05 57_[+3]_15 chr21:46494196-46494276 4.9e-05 16_[+3]_56 chr12:121647912-12164799 9.8e-05 42_[+3]_30 chr6:111196884-111196964 9.8e-05 28_[+3]_44 chr12:110719407-11071948 9.8e-05 17_[+3]_55 chr12:123465329-12346540 9.8e-05 13_[+3]_59 chr1:31628261-31628341 9.8e-05 70_[+3]_2 chr12:46122878-46122958 9.8e-05 [+3]_72 chr17:7145693-7145773 9.8e-05 16_[+3]_56 chr6:34203574-34203654 9.8e-05 56_[+3]_16 chr11:118965647-11896572 0.00015 11_[+3]_61 chr7:141251354-141251434 0.00015 49_[+3]_23 chr16:31191899-31191979 0.00015 61_[+3]_11 chr6:74230176-74230256 0.00015 38_[+3]_34 chr5:170815512-170815592 0.00015 31_[+3]_41 chr6:34204480-34204560 0.00015 53_[+3]_19 chr16:9185515-9185595 0.00015 49_[+3]_23 chr10:97416526-97416606 0.00015 25_[+3]_47 chr1:206808693-206808773 0.00022 72_[+3] chr1:247094861-247094941 0.00022 35_[+3]_37 chr11:72533271-72533351 0.00022 24_[+3]_48 chr17:62501684-62501764 0.00022 1_[+3]_71 chr21:46494399-46494479 0.00022 59_[+3]_13 chr11:93474368-93474448 0.00022 41_[+3]_31 chr11:62432805-62432885 0.00022 71_[+3]_1 chr2:178077860-178077940 0.00022 37_[+3]_35 chr6:30689270-30689350 0.00022 2_[+3]_70 chr8:99956634-99956714 0.00022 52_[+3]_20 chr9:103361120-103361200 0.00022 29_[+3]_43 chr12:76478113-76478193 0.0003 33_[+3]_39 chr9:91926412-91926492 0.0003 47_[+3]_25 chr8:66754286-66754366 0.0003 71_[+3]_1 chr1:205718721-205718801 0.0003 9_[+3]_63 chr1:116915832-116915912 0.0003 40_[+3]_32 chr17:74732617-74732697 0.0003 65_[+3]_7 chr21:46494599-46494679 0.0003 [+3]_72 chr7:148581855-148581935 0.00039 66_[+3]_6 chr17:79679538-79679618 0.00039 20_[+3]_52 chr6:41863154-41863234 0.00039 41_[+3]_31 chr8:144897998-144898078 0.00039 60_[+3]_12 chr21:45284491-45284571 0.00039 5_[+3]_67 chr1:27561013-27561093 0.00039 1_[+3]_71 chrX:41193826-41193906 0.00039 71_[+3]_1 chr1:26232363-26232443 0.00039 35_[+3]_37 chr19:55919097-55919177 0.00049 58_[+3]_14 chr19:13208381-13208461 0.00049 3_[+3]_69 chr3:9438608-9438688 0.00049 36_[+3]_36 chr5:176873952-176874032 0.00049 16_[+3]_56 chr15:60771183-60771263 0.00049 26_[+3]_46 chr19:10226603-10226683 0.00049 65_[+3]_7 chr6:44215193-44215273 0.00049 23_[+3]_49 chr9:130829531-130829611 0.00049 37_[+3]_35 chr6:34360466-34360546 0.00049 2_[+3]_70 chr17:73775438-73775518 0.00057 38_[+3]_34 chr11:65190701-65190781 0.00057 9_[+3]_63 chr22:41842712-41842792 0.00057 72_[+3] chr11:65625052-65625132 0.00081 12_[+3]_60 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SGGCGSSG MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF SGGCGSSG width=8 seqs=64 chr19:50180628-50180708 ( 67) GGGCGCCG 1 chr11:65666925-65667005 ( 70) GGGCGCCG 1 chr7:5569342-5569422 ( 37) GGGCGCCG 1 chr21:46494947-46495027 ( 17) GGGCGCCG 1 chr4:184365630-184365710 ( 56) CGGCGCCG 1 chr6:158981309-158981389 ( 31) CGGCGCCG 1 chr20:60962322-60962402 ( 31) CGGCGCCG 1 chr5:176873595-176873675 ( 58) CGGCGCCG 1 chr21:46494196-46494276 ( 17) CGGCGCCG 1 chr12:121647912-12164799 ( 43) GGGCGGCG 1 chr6:111196884-111196964 ( 29) GGGCGCGG 1 chr12:110719407-11071948 ( 18) GGGCGCGG 1 chr12:123465329-12346540 ( 14) GGGCGCGG 1 chr1:31628261-31628341 ( 71) GGGCGGCG 1 chr12:46122878-46122958 ( 1) GGGCGGCG 1 chr17:7145693-7145773 ( 17) GGGCGGCG 1 chr6:34203574-34203654 ( 57) GGGCGCGG 1 chr11:118965647-11896572 ( 12) CGGCGCGG 1 chr7:141251354-141251434 ( 50) CGGCGCGG 1 chr16:31191899-31191979 ( 62) CGGCGCGG 1 chr6:74230176-74230256 ( 39) CGGCGGCG 1 chr5:170815512-170815592 ( 32) CGGCGCGG 1 chr6:34204480-34204560 ( 54) CGGCGGCG 1 chr16:9185515-9185595 ( 50) CGGCGGCG 1 chr10:97416526-97416606 ( 26) CGGCGCGG 1 chr1:206808693-206808773 ( 73) GGGCCCCG 1 chr1:247094861-247094941 ( 36) GCGCGCCG 1 chr11:72533271-72533351 ( 25) GCGCGCCG 1 chr17:62501684-62501764 ( 2) GGGCGGGG 1 chr21:46494399-46494479 ( 60) GGGCGGGG 1 chr11:93474368-93474448 ( 42) GGGCCCCG 1 chr11:62432805-62432885 ( 72) GGGCGGGG 1 chr2:178077860-178077940 ( 38) GGGCCCCG 1 chr6:30689270-30689350 ( 3) GGGCCCCG 1 chr8:99956634-99956714 ( 53) GGGCGGGG 1 chr9:103361120-103361200 ( 30) GCGCGCCG 1 chr12:76478113-76478193 ( 34) CGGCCCCG 1 chr9:91926412-91926492 ( 48) CCGCGCCG 1 chr8:66754286-66754366 ( 72) CCGCGCCG 1 chr1:205718721-205718801 ( 10) CGGCCCCG 1 chr1:116915832-116915912 ( 41) CGGCGGGG 1 chr17:74732617-74732697 ( 66) CCGCGCCG 1 chr21:46494599-46494679 ( 1) CCGCGCCG 1 chr7:148581855-148581935 ( 67) GCGCGCGG 1 chr17:79679538-79679618 ( 21) GGGCCCGG 1 chr6:41863154-41863234 ( 42) GGGCCGCG 1 chr8:144897998-144898078 ( 61) GCGCGCGG 1 chr21:45284491-45284571 ( 6) GCGCGGCG 1 chr1:27561013-27561093 ( 2) GGGCCCGG 1 chrX:41193826-41193906 ( 72) GCGCGGCG 1 chr1:26232363-26232443 ( 36) GGGCCCGG 1 chr19:55919097-55919177 ( 59) CGGCCGCG 1 chr19:13208381-13208461 ( 4) CGGCCGCG 1 chr3:9438608-9438688 ( 37) CGGCCGCG 1 chr5:176873952-176874032 ( 17) CCGCGGCG 1 chr15:60771183-60771263 ( 27) CCGCGGCG 1 chr19:10226603-10226683 ( 66) CCGCGGCG 1 chr6:44215193-44215273 ( 24) CCGCGCGG 1 chr9:130829531-130829611 ( 38) CGGCCCGG 1 chr6:34360466-34360546 ( 3) CGGCCGCG 1 chr17:73775438-73775518 ( 39) GCGCGGGG 1 chr11:65190701-65190781 ( 10) GGGCCGGG 1 chr22:41842712-41842792 ( 73) GCGCCCCG 1 chr11:65625052-65625132 ( 13) GGGCGCAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SGGCGSSG MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.89106 E= 7.9e-006 -1264 77 105 -1264 -1264 0 147 -1264 -1264 -1264 192 -1264 -1264 191 -1264 -1264 -1264 0 147 -1264 -1264 123 50 -1264 -393 123 44 -1264 -1264 -1264 192 -1264 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SGGCGSSG MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 64 E= 7.9e-006 0.000000 0.453125 0.546875 0.000000 0.000000 0.265625 0.734375 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.265625 0.734375 0.000000 0.000000 0.625000 0.375000 0.000000 0.015625 0.625000 0.359375 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif SGGCGSSG MEME-3 regular expression -------------------------------------------------------------------------------- [GC][GC]GC[GC][CG][CG]G -------------------------------------------------------------------------------- Time 12.51 secs. ******************************************************************************** ******************************************************************************** MOTIF CCCCKCCC MEME-4 width = 8 sites = 36 llr = 295 E-value = 6.5e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCCCKCCC MEME-4 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C 8899:aa9 probability G 22::4::1 matrix T ::116::: bits 2.1 1.9 ** 1.7 * ** 1.5 ** *** Relative 1.3 **** *** Entropy 1.1 ******** (11.8 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CCCCTCCC consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCKCCC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:13208381-13208461 26 2.18e-05 TCCCCGGGCG CCCCTCCC TGGGGCCCAG chr3:9438608-9438688 17 2.18e-05 CACTGACCCT CCCCTCCC GCCGCAGGAG chr17:39845559-39845639 38 2.18e-05 GCCACACCCG CCCCTCCC GTCACCATTG chr5:56111284-56111364 69 2.18e-05 CTCTCCCCGC CCCCTCCC TCCC chr1:245026525-245026605 6 2.18e-05 CCTCT CCCCTCCC CCCGAGACAT chr11:65625052-65625132 5 2.18e-05 CCCG CCCCTCCC GGGCGCAGGC chr16:31191899-31191979 48 2.18e-05 GCTCTGCGGG CCCCTCCC CCTTCGCGGC chr1:205718721-205718801 53 2.18e-05 TGACTTCACA CCCCTCCC CCTCCGGCCG chr6:34204480-34204560 16 2.18e-05 CTCCCACACG CCCCTCCC TGCCGTCAGC chr21:46494947-46495027 7 2.18e-05 CCGCGT CCCCTCCC GAGGGCGCCG chr3:169482812-169482892 9 2.18e-05 GGCCACCA CCCCTCCC AGGCCCACCC chr7:100026358-100026438 6 4.67e-05 CCCGT CCCCGCCC ACACTCGCTG chr21:46494399-46494479 20 4.67e-05 GCTgcgccgc ccccgccc cctcggcgtg chr6:30689270-30689350 40 4.67e-05 TTGTCCCTGG CCCCGCCC ACGCGCGAAG chr1:206808693-206808773 15 9.01e-05 TCCAACCTCC CGCCTCCC GCGCCAGTAC chr7:111202318-111202398 40 9.01e-05 CGCACCCCTC CGCCTCCC GGCAAcgccc chr6:111196884-111196964 46 9.01e-05 GATAGGAGGG GCCCTCCC GGCCTTGTCT chr11:93474368-93474448 69 9.01e-05 AGATATGCAA CGCCTCCC CCGC chr6:34360466-34360546 43 9.01e-05 CGCGAATCGC GCCCTCCC AGTTCGCGCG chr1:247094861-247094941 6 1.09e-04 TCCCT CCCTTCCC CCTACCTGAA chr17:56408821-56408901 71 1.09e-04 gttccctctt cccttccc cc chr8:146012621-146012701 16 1.80e-04 cgccccgcgc gcccgccc ccgccgggcT chr8:144897998-144898078 52 1.80e-04 GGGAAgccgg gcccgccc cgcgcgcggg chr19:55919097-55919177 30 1.80e-04 TAGACCAACC CGCCGCCC CGGTGCCCGG chr3:9438296-9438376 37 1.80e-04 TCGGCCGGCA GCCCGCCC CCGCCTCCAG chr7:148823313-148823393 31 1.80e-04 GGCACGGCCT CCCCTCCG CTCCGCCCCA chr7:44836603-44836683 39 1.80e-04 GCCCGCGTCC GCCCGCCC GCCTCATGTG chr1:26232363-26232443 47 1.80e-04 GGCCCGGGAG CGCCGCCC CTCAATCACC chr21:46494599-46494679 33 1.80e-04 cgaggcagag cgccgccc ggcgcgagac chr17:79479461-79479541 17 2.02e-04 GAAGCCTCGG CCCTGCCC CAACCCCAGC chr1:26232602-26232682 52 2.02e-04 TCGCCCAGCC CCCTGCCC ACGAACAGCC chr19:50180628-50180708 52 2.27e-04 GTTGGAGGTC CCCCGCCG CACACGGGGG chr17:62223685-62223765 29 2.27e-04 GTCTTTGAGC CCCCGCCG AGCTTCCTCG chr11:10830610-10830690 32 2.27e-04 TGCGGCGCAG CCCCGCCG CAGTGCGCAA chr10:70516096-70516176 72 2.46e-04 AGTGGGAAAC CCTCTCCC G chr3:75765902-75765982 51 2.46e-04 ACCAGGGCAG CCTCTCCC AAGAATACTA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCKCCC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:13208381-13208461 2.2e-05 25_[+4]_47 chr3:9438608-9438688 2.2e-05 16_[+4]_56 chr17:39845559-39845639 2.2e-05 37_[+4]_35 chr5:56111284-56111364 2.2e-05 68_[+4]_4 chr1:245026525-245026605 2.2e-05 5_[+4]_67 chr11:65625052-65625132 2.2e-05 4_[+4]_68 chr16:31191899-31191979 2.2e-05 47_[+4]_25 chr1:205718721-205718801 2.2e-05 52_[+4]_20 chr6:34204480-34204560 2.2e-05 15_[+4]_57 chr21:46494947-46495027 2.2e-05 6_[+4]_66 chr3:169482812-169482892 2.2e-05 8_[+4]_64 chr7:100026358-100026438 4.7e-05 5_[+4]_67 chr21:46494399-46494479 4.7e-05 19_[+4]_53 chr6:30689270-30689350 4.7e-05 39_[+4]_33 chr1:206808693-206808773 9e-05 14_[+4]_58 chr7:111202318-111202398 9e-05 39_[+4]_33 chr6:111196884-111196964 9e-05 45_[+4]_27 chr11:93474368-93474448 9e-05 68_[+4]_4 chr6:34360466-34360546 9e-05 42_[+4]_30 chr1:247094861-247094941 0.00011 5_[+4]_67 chr17:56408821-56408901 0.00011 70_[+4]_2 chr8:146012621-146012701 0.00018 15_[+4]_57 chr8:144897998-144898078 0.00018 51_[+4]_21 chr19:55919097-55919177 0.00018 29_[+4]_43 chr3:9438296-9438376 0.00018 36_[+4]_36 chr7:148823313-148823393 0.00018 30_[+4]_42 chr7:44836603-44836683 0.00018 38_[+4]_34 chr1:26232363-26232443 0.00018 46_[+4]_26 chr21:46494599-46494679 0.00018 32_[+4]_40 chr17:79479461-79479541 0.0002 16_[+4]_56 chr1:26232602-26232682 0.0002 51_[+4]_21 chr19:50180628-50180708 0.00023 51_[+4]_21 chr17:62223685-62223765 0.00023 28_[+4]_44 chr11:10830610-10830690 0.00023 31_[+4]_41 chr10:70516096-70516176 0.00025 71_[+4]_1 chr3:75765902-75765982 0.00025 50_[+4]_22 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCKCCC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCCCKCCC width=8 seqs=36 chr19:13208381-13208461 ( 26) CCCCTCCC 1 chr3:9438608-9438688 ( 17) CCCCTCCC 1 chr17:39845559-39845639 ( 38) CCCCTCCC 1 chr5:56111284-56111364 ( 69) CCCCTCCC 1 chr1:245026525-245026605 ( 6) CCCCTCCC 1 chr11:65625052-65625132 ( 5) CCCCTCCC 1 chr16:31191899-31191979 ( 48) CCCCTCCC 1 chr1:205718721-205718801 ( 53) CCCCTCCC 1 chr6:34204480-34204560 ( 16) CCCCTCCC 1 chr21:46494947-46495027 ( 7) CCCCTCCC 1 chr3:169482812-169482892 ( 9) CCCCTCCC 1 chr7:100026358-100026438 ( 6) CCCCGCCC 1 chr21:46494399-46494479 ( 20) CCCCGCCC 1 chr6:30689270-30689350 ( 40) CCCCGCCC 1 chr1:206808693-206808773 ( 15) CGCCTCCC 1 chr7:111202318-111202398 ( 40) CGCCTCCC 1 chr6:111196884-111196964 ( 46) GCCCTCCC 1 chr11:93474368-93474448 ( 69) CGCCTCCC 1 chr6:34360466-34360546 ( 43) GCCCTCCC 1 chr1:247094861-247094941 ( 6) CCCTTCCC 1 chr17:56408821-56408901 ( 71) CCCTTCCC 1 chr8:146012621-146012701 ( 16) GCCCGCCC 1 chr8:144897998-144898078 ( 52) GCCCGCCC 1 chr19:55919097-55919177 ( 30) CGCCGCCC 1 chr3:9438296-9438376 ( 37) GCCCGCCC 1 chr7:148823313-148823393 ( 31) CCCCTCCG 1 chr7:44836603-44836683 ( 39) GCCCGCCC 1 chr1:26232363-26232443 ( 47) CGCCGCCC 1 chr21:46494599-46494679 ( 33) CGCCGCCC 1 chr17:79479461-79479541 ( 17) CCCTGCCC 1 chr1:26232602-26232682 ( 52) CCCTGCCC 1 chr19:50180628-50180708 ( 52) CCCCGCCG 1 chr17:62223685-62223765 ( 29) CCCCGCCG 1 chr11:10830610-10830690 ( 32) CCCCGCCG 1 chr10:70516096-70516176 ( 72) CCTCTCCC 1 chr3:75765902-75765982 ( 51) CCTCTCCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCKCCC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.389 E= 6.5e-001 -1181 165 -67 -1181 -1181 165 -67 -1181 -1181 183 -1181 -205 -1181 174 -1181 -105 -1181 -1181 65 134 -1181 191 -1181 -1181 -1181 191 -1181 -1181 -1181 174 -125 -1181 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCKCCC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 36 E= 6.5e-001 0.000000 0.833333 0.166667 0.000000 0.000000 0.833333 0.166667 0.000000 0.000000 0.944444 0.000000 0.055556 0.000000 0.888889 0.000000 0.111111 0.000000 0.000000 0.416667 0.583333 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.888889 0.111111 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCKCCC MEME-4 regular expression -------------------------------------------------------------------------------- CCCC[TG]CCC -------------------------------------------------------------------------------- Time 16.10 secs. ******************************************************************************** ******************************************************************************** MOTIF TTTWTAWW MEME-5 width = 8 sites = 17 llr = 157 E-value = 1.3e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTTWTAWW MEME-5 Description -------------------------------------------------------------------------------- Simplified A :::4:a56 pos.-specific C :::::::: probability G :::2:::: matrix T aaa4a:54 bits 2.1 *** ** 1.9 *** ** 1.7 *** ** 1.5 *** ** Relative 1.3 *** ** Entropy 1.1 *** **** (13.3 bits) 0.8 *** **** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TTTATATA consensus T AT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTWTAWW MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr21:38469087-38469167 3 1.75e-05 GC TTTATATA TAATAACAAC chr17:56407466-56407546 50 1.75e-05 CATGGTTTGA TTtatata tatatatcac chr17:56407823-56407903 73 1.75e-05 TTTTGCCCAA TTTTTATA chr5:145862982-145863062 25 3.55e-05 TTATGTCTCC TTTATAAA CAGATATCCT chr1:186325393-186325473 10 3.55e-05 TAAAATAAC TTTATAAA AACCTACCAT chr11:65274492-65274572 68 3.55e-05 TCCTTTTAAG TTTTTAAA CCAGT chr17:56756807-56756887 62 3.55e-05 ACGTACGCCT TTTATAAA CAAGCCAGAT chr1:186327627-186327707 11 3.55e-05 GGCAGTCAGG TTTTTAAA AGTAGGAAAA chr7:111101559-111101639 3 5.24e-05 ca tttttatt cccaATATAT chr4:54291927-54292007 33 5.24e-05 ACACATTTTG TTTTTATT TCTCACTGCT chr7:135278888-135278968 60 5.24e-05 TCATCCATAC TTTATATT GCAGTATAAT chr10:70513539-70513619 26 5.24e-05 TGTGTAACCT TTTTTATT AAGGCTATTT chr10:70738077-70738157 71 6.99e-05 tggtatgtga tttttaAT TG chr13:91602190-91602270 15 6.99e-05 AAGTAAACTG TTTATAAT TATATAAAAT chr12:48081105-48081185 53 7.98e-05 TGTATTGGAA TTTGTATA CCTGATTTCA chr22:22848230-22848310 12 7.98e-05 cacccccaaa tttgtata ctgaagctat chr18:23616813-23616893 5 9.00e-05 agtt tttgtaaa taaaatttta -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTWTAWW MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr21:38469087-38469167 1.7e-05 2_[+5]_70 chr17:56407466-56407546 1.7e-05 49_[+5]_23 chr17:56407823-56407903 1.7e-05 72_[+5] chr5:145862982-145863062 3.5e-05 24_[+5]_48 chr1:186325393-186325473 3.5e-05 9_[+5]_63 chr11:65274492-65274572 3.5e-05 67_[+5]_5 chr17:56756807-56756887 3.5e-05 61_[+5]_11 chr1:186327627-186327707 3.5e-05 10_[+5]_62 chr7:111101559-111101639 5.2e-05 2_[+5]_70 chr4:54291927-54292007 5.2e-05 32_[+5]_40 chr7:135278888-135278968 5.2e-05 59_[+5]_13 chr10:70513539-70513619 5.2e-05 25_[+5]_47 chr10:70738077-70738157 7e-05 70_[+5]_2 chr13:91602190-91602270 7e-05 14_[+5]_58 chr12:48081105-48081185 8e-05 52_[+5]_20 chr22:22848230-22848310 8e-05 11_[+5]_61 chr18:23616813-23616893 9e-05 4_[+5]_68 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTWTAWW MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTTWTAWW width=8 seqs=17 chr21:38469087-38469167 ( 3) TTTATATA 1 chr17:56407466-56407546 ( 50) TTTATATA 1 chr17:56407823-56407903 ( 73) TTTTTATA 1 chr5:145862982-145863062 ( 25) TTTATAAA 1 chr1:186325393-186325473 ( 10) TTTATAAA 1 chr11:65274492-65274572 ( 68) TTTTTAAA 1 chr17:56756807-56756887 ( 62) TTTATAAA 1 chr1:186327627-186327707 ( 11) TTTTTAAA 1 chr7:111101559-111101639 ( 3) TTTTTATT 1 chr4:54291927-54292007 ( 33) TTTTTATT 1 chr7:135278888-135278968 ( 60) TTTATATT 1 chr10:70513539-70513619 ( 26) TTTTTATT 1 chr10:70738077-70738157 ( 71) TTTTTAAT 1 chr13:91602190-91602270 ( 15) TTTATAAT 1 chr12:48081105-48081185 ( 53) TTTGTATA 1 chr22:22848230-22848310 ( 12) TTTGTATA 1 chr18:23616813-23616893 ( 5) TTTGTAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTWTAWW MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.8333 E= 1.3e+003 -1073 -1073 -1073 212 -1073 -1073 -1073 212 -1073 -1073 -1073 212 79 -1073 -58 84 -1073 -1073 -1073 212 207 -1073 -1073 -1073 98 -1073 -1073 120 144 -1073 -1073 61 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTWTAWW MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 17 E= 1.3e+003 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.411765 0.000000 0.176471 0.411765 0.000000 0.000000 0.000000 1.000000 1.000000 0.000000 0.000000 0.000000 0.470588 0.000000 0.000000 0.529412 0.647059 0.000000 0.000000 0.352941 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTTWTAWW MEME-5 regular expression -------------------------------------------------------------------------------- TTT[AT]TA[TA][AT] -------------------------------------------------------------------------------- Time 19.64 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr5:42730811-42730891 4.55e-01 80 chr9:126031136-126031216 7.19e-01 80 chr10:97416526-97416606 2.65e-01 80 chr4:56483261-56483341 3.33e-01 80 chr3:119813415-119813495 3.29e-01 80 chr2:149402921-149403001 5.35e-01 80 chr14:95623791-95623871 6.61e-01 80 chr7:92205253-92205333 6.72e-02 80 chr11:61447780-61447860 4.91e-01 80 chr17:30688438-30688518 1.92e-03 63_[+2(2.12e-05)]_9 chr2:196521864-196521944 7.12e-01 80 chr11:64053169-64053249 4.70e-01 80 chr1:186327627-186327707 1.25e-03 10_[+5(3.55e-05)]_6_[+2(5.27e-05)]_\ 48 chr17:56404226-56404306 8.38e-01 80 chr3:142505222-142505302 1.68e-01 80 chr1:186330501-186330581 6.69e-04 28_[+2(5.27e-05)]_17_[+1(4.40e-05)]_\ 2_[+2(3.09e-05)]_9 chr3:169482812-169482892 8.96e-03 8_[+4(2.18e-05)]_64 chr13:91076829-91076909 8.97e-02 80 chr19:10224887-10224967 5.02e-01 80 chr1:186331746-186331826 6.89e-02 80 chr12:112512490-11251257 9.48e-01 80 chr12:125406276-12540635 7.52e-01 80 chr12:123810093-12381017 3.29e-01 80 chr10:70513321-70513401 1.92e-01 80 chr21:46494599-46494679 7.89e-02 80 chr5:84624211-84624291 2.95e-02 80 chr21:46494947-46495027 4.41e-03 6_[+4(2.18e-05)]_2_[+3(2.46e-05)]_\ 56 chr1:28837167-28837247 4.81e-01 80 chr11:65269477-65269557 1.09e-01 80 chr7:35840722-35840802 7.20e-01 80 chr1:186315221-186315301 3.31e-02 13_[+2(5.27e-05)]_59 chr18:22937073-22937153 6.69e-03 15_[+1(8.94e-05)]_57 chr17:74732617-74732697 6.97e-02 80 chr7:120768792-120768872 2.29e-01 80 chr17:7476405-7476485 7.13e-01 80 chr11:65190900-65190980 8.03e-01 80 chr2:232328548-232328628 7.00e-01 80 chr6:34360466-34360546 7.84e-02 42_[+4(9.01e-05)]_30 chr9:103361120-103361200 4.60e-02 80 chr1:156286875-156286955 1.86e-01 80 chr8:99956634-99956714 4.53e-01 80 chr3:75765902-75765982 1.97e-01 80 chr22:38902429-38902509 7.37e-03 25_[+1(4.40e-05)]_15_[+2(5.27e-05)]_\ 24 chr16:9185515-9185595 4.12e-01 80 chr1:186305766-186305846 3.08e-02 69_[+2(5.27e-05)]_3 chr21:46494196-46494276 1.53e-01 16_[+3(4.93e-05)]_56 chr4:166248482-166248562 8.04e-01 80 chr5:37324386-37324466 1.79e-05 15_[+2(2.12e-05)]_30_[+1(1.70e-05)]_\ 19 chr6:28703182-28703262 6.34e-01 80 chr8:145739405-145739485 6.89e-01 80 chr20:62328192-62328272 8.94e-01 80 chr6:16129413-16129493 5.34e-01 80 chr22:41842712-41842792 2.47e-01 80 chr21:33041990-33042070 3.22e-03 62_[+5(3.55e-05)]_10 chr17:56407823-56407903 1.00e-02 6_[+5(7.98e-05)]_58_[+5(1.75e-05)] chr1:236750871-236750951 5.70e-02 38_[+2(7.21e-05)]_34 chr1:26232363-26232443 8.98e-02 80 chr7:44836603-44836683 2.70e-01 80 chr7:135283799-135283879 3.99e-03 28_[+1(5.26e-05)]_44 chrX:41193826-41193906 5.53e-01 80 chr9:130829531-130829611 3.34e-01 80 chr6:34204480-34204560 1.53e-02 15_[+4(2.18e-05)]_57 chr11:65190701-65190781 8.10e-02 80 chr5:170815512-170815592 4.48e-01 80 chr1:26232602-26232682 3.27e-01 80 chr10:49824815-49824895 7.10e-01 80 chr10:70513539-70513619 2.51e-02 25_[+5(5.24e-05)]_47 chr1:186295128-186295208 1.29e-01 80 chr1:28836876-28836956 9.98e-01 80 chr7:26240456-26240536 8.12e-01 80 chr18:2771817-2771897 4.91e-01 80 chr17:25414773-25414853 2.71e-02 49_[+2(3.09e-05)]_23 chr13:92287130-92287210 6.06e-01 80 chr6:30689270-30689350 7.80e-04 5_[+4(4.67e-05)]_26_[+4(4.67e-05)]_\ 33 chr13:91376285-91376365 1.76e-01 80 chr10:70516096-70516176 1.30e-03 17_[+1(8.35e-06)]_55 chr3:186501871-186501951 5.96e-01 80 chr11:10830610-10830690 1.33e-01 80 chr6:34203574-34203654 1.49e-01 56_[+3(9.83e-05)]_16 chr18:23616611-23616691 8.39e-02 80 chr5:176873595-176873675 2.29e-01 57_[+3(4.93e-05)]_15 chr4:73654270-73654350 6.79e-01 80 chr17:7145693-7145773 2.73e-01 16_[+3(9.83e-05)]_56 chr1:27561013-27561093 4.48e-01 80 chr21:45284491-45284571 3.27e-01 80 chr7:148823313-148823393 3.18e-01 80 chr13:93320058-93320138 4.67e-01 80 chr1:116915832-116915912 2.97e-02 80 chr6:74230176-74230256 1.62e-01 80 chr7:82536220-82536300 7.23e-03 53_[+1(5.26e-05)]_19 chr7:135278888-135278968 1.45e-03 13_[+1(1.70e-05)]_38_[+5(5.24e-05)]_\ 13 chr11:65274293-65274373 8.00e-01 80 chr1:144534211-144534291 1.34e-01 80 chr17:56408584-56408664 6.88e-01 80 chr13:91602190-91602270 8.42e-03 14_[+5(6.99e-05)]_58 chr17:79479461-79479541 3.35e-01 80 chr2:178077860-178077940 1.64e-01 80 chr17:62223485-62223565 4.27e-01 80 chr3:47459687-47459767 9.67e-01 80 chr2:121832771-121832851 6.56e-01 80 chr1:205718721-205718801 2.34e-02 52_[+4(2.18e-05)]_20 chr17:56407466-56407546 4.59e-02 49_[+5(1.75e-05)]_23 chr10:70738077-70738157 5.79e-04 9_[+2(5.27e-05)]_1_[+2(5.27e-05)]_\ 44_[+5(6.99e-05)]_2 chr3:75761475-75761555 9.16e-03 71_[+5(9.95e-05)]_1 chr1:78469981-78470061 1.87e-02 52_[+1(9.90e-05)]_20 chr6:44215193-44215273 2.11e-01 80 chr6:147632625-147632705 8.82e-02 80 chr1:45187319-45187399 6.41e-01 80 chr8:54887787-54887867 1.44e-01 80 chr1:109642858-109642938 9.99e-01 80 chr3:9438296-9438376 1.85e-01 80 chr10:87245150-87245230 1.25e-02 19_[+2(6.24e-05)]_53 chr1:186307021-186307101 1.35e-01 80 chr5:137802145-137802225 4.40e-01 80 chr7:5569342-5569422 9.97e-02 36_[+3(2.46e-05)]_36 chr18:9925801-9925881 3.15e-02 80 chr3:195808911-195808991 8.16e-01 80 chr17:56736316-56736396 4.23e-03 4_[+1(9.90e-05)]_68 chr17:56408821-56408901 3.83e-01 80 chr20:47904169-47904249 4.23e-01 80 chr12:46122878-46122958 1.78e-01 [+3(9.83e-05)]_72 chr4:54291927-54292007 1.90e-04 [+1(8.35e-06)]_24_[+5(5.24e-05)]_13_\ [+1(2.56e-05)]_19 chr19:10226603-10226683 3.52e-01 80 chr1:31628261-31628341 3.39e-01 70_[+3(9.83e-05)]_2 chr6:26055622-26055702 4.43e-03 29_[+1(8.94e-05)]_43 chr1:186297574-186297654 6.27e-04 12_[+1(1.70e-05)]_60 chr16:31191899-31191979 1.53e-02 47_[+4(2.18e-05)]_25 chr10:70721227-70721307 8.04e-03 12_[+1(2.56e-05)]_60 chr11:65625052-65625132 4.56e-02 4_[+4(2.18e-05)]_68 chr20:62328424-62328504 4.55e-01 80 chr1:175970051-175970131 9.69e-02 80 chr12:123465329-12346540 3.98e-01 13_[+3(9.83e-05)]_59 chr11:62432805-62432885 3.52e-01 80 chr17:56756807-56756887 6.04e-02 61_[+5(3.55e-05)]_11 chr6:26160001-26160081 1.10e-03 60_[+1(3.44e-05)]_12 chr7:135300253-135300333 7.47e-03 3_[+1(5.26e-05)]_69 chr1:245026525-245026605 8.25e-02 5_[+4(2.18e-05)]_67 chr1:45196466-45196546 1.35e-01 4_[+2(2.12e-05)]_68 chr12:110719407-11071948 3.21e-01 17_[+3(9.83e-05)]_55 chr11:65274492-65274572 1.44e-02 67_[+5(3.55e-05)]_5 chr2:170667920-170668000 7.07e-01 80 chr4:39780906-39780986 3.04e-02 80 chr11:65666925-65667005 8.69e-02 69_[+3(2.46e-05)]_3 chr6:26123396-26123476 8.75e-01 80 chr21:30433064-30433144 7.73e-01 80 chr1:236757449-236757529 8.36e-04 1_[+1(8.35e-06)]_71 chr21:30439772-30439852 1.59e-02 80 chr17:39834694-39834774 3.39e-01 80 chr5:56111284-56111364 4.63e-02 68_[+4(2.18e-05)]_4 chr17:39845559-39845639 8.24e-02 37_[+4(2.18e-05)]_35 chr16:18812830-18812910 5.77e-01 80 chr13:91044375-91044455 3.18e-03 35_[+1(3.44e-05)]_37 chr17:62223685-62223765 9.66e-02 80 chr13:91044095-91044175 1.28e-01 80 chr15:60771183-60771263 2.10e-01 80 chr6:28726079-28726159 6.68e-01 80 chr11:95614038-95614118 4.03e-03 54_[+1(6.15e-05)]_9_[+2(6.24e-05)]_\ 1 chr5:179126088-179126168 9.76e-01 80 chr11:93474368-93474448 4.39e-02 68_[+4(9.01e-05)]_4 chr8:48774409-48774489 4.94e-02 80 chr19:15490304-15490384 8.84e-01 80 chr16:29817096-29817176 8.67e-01 80 chr19:18682800-18682880 8.18e-01 80 chr2:190649056-190649136 3.26e-01 80 chr21:46494399-46494479 3.29e-02 19_[+4(4.67e-05)]_53 chr11:118350703-11835078 4.30e-01 80 chr5:176873952-176874032 6.56e-01 80 chr8:66754286-66754366 1.31e-01 80 chr1:19496276-19496356 4.12e-01 80 chr3:9438608-9438688 2.79e-02 16_[+4(2.18e-05)]_56 chr9:91926412-91926492 2.96e-01 80 chr19:13208381-13208461 3.35e-02 25_[+4(2.18e-05)]_47 chr19:55919097-55919177 1.20e-01 80 chr8:144897998-144898078 9.74e-02 80 chr1:17231840-17231920 5.78e-02 7_[+1(7.14e-05)]_65 chr11:64009199-64009279 8.80e-01 80 chr19:52073667-52073747 2.42e-03 28_[+5(3.55e-05)]_44 chr6:41863154-41863234 4.48e-01 80 chr17:43226078-43226158 4.23e-01 80 chr5:145531206-145531286 2.02e-02 56_[+2(5.27e-05)]_16 chr20:60962322-60962402 1.40e-01 30_[+3(4.93e-05)]_42 chr6:31802756-31802836 8.17e-01 80 chr1:145105716-145105796 3.14e-02 57_[+1(2.56e-05)]_15 chr7:141251354-141251434 5.16e-01 80 chr19:50180628-50180708 2.09e-02 66_[+3(2.46e-05)]_6 chr17:62501684-62501764 2.02e-02 80 chr17:79679538-79679618 1.84e-01 80 chr7:111101559-111101639 2.03e-02 2_[+5(5.24e-05)]_70 chr12:76478113-76478193 2.72e-01 80 chr10:70721014-70721094 1.67e-02 80 chr1:186325393-186325473 7.74e-03 9_[+5(3.55e-05)]_63 chr5:145551038-145551118 4.33e-03 65_[+2(2.12e-05)]_7 chr1:147735953-147736033 8.22e-01 80 chr21:30432782-30432862 1.43e-04 15_[+2(3.09e-05)]_25_[+5(3.55e-05)]_\ 24 chr22:22848230-22848310 1.22e-01 11_[+5(7.98e-05)]_61 chr6:33244892-33244972 3.19e-01 80 chr17:73775438-73775518 4.17e-01 80 chr12:120729326-12072940 1.58e-01 80 chr21:38469087-38469167 2.06e-03 2_[+5(1.75e-05)]_56_[+1(2.56e-05)]_\ 6 chr6:111196884-111196964 1.27e-02 28_[+3(9.83e-05)]_9_[+4(9.01e-05)]_\ 27 chr6:27862834-27862914 3.85e-01 80 chr21:30440007-30440087 4.58e-01 80 chr1:52706113-52706193 1.88e-01 80 chr6:28626026-28626106 9.24e-01 80 chr7:148581855-148581935 1.85e-02 80 chr7:103796963-103797043 1.21e-01 80 chr7:120766476-120766556 3.58e-03 55_[+2(6.24e-05)]_17 chr1:245006482-245006562 4.99e-01 80 chr1:148241508-148241588 7.84e-01 80 chr10:70727412-70727492 2.76e-01 80 chr17:30694524-30694604 5.53e-01 80 chr16:70575247-70575327 9.24e-03 9_[+1(3.44e-05)]_49_[+1(6.15e-05)]_\ 6 chr12:48081105-48081185 2.81e-02 52_[+5(7.98e-05)]_20 chr6:119513457-119513537 8.54e-03 16_[+2(9.99e-06)]_56 chr7:108538402-108538482 7.26e-02 18_[+2(5.27e-05)]_22_[+2(5.27e-05)]_\ 24 chr18:20153233-20153313 6.30e-03 34_[+2(2.12e-05)]_38 chr3:149687920-149688000 2.22e-01 80 chr1:186328558-186328638 4.17e-02 55_[+1(2.56e-05)]_17 chr13:92116346-92116426 5.03e-01 80 chr7:136084420-136084500 6.21e-03 54_[+1(2.56e-05)]_18 chr7:111202318-111202398 8.02e-02 39_[+4(9.01e-05)]_33 chr3:142502375-142502455 3.69e-02 80 chr7:103213988-103214068 3.39e-03 45_[+1(8.35e-06)]_27 chr7:100026358-100026438 2.79e-02 5_[+4(4.67e-05)]_67 chr7:135302804-135302884 5.35e-02 80 chr6:158981309-158981389 2.21e-01 30_[+3(4.93e-05)]_42 chr11:72533271-72533351 4.47e-01 80 chr1:247094861-247094941 5.59e-02 80 chr8:146012621-146012701 1.28e-01 80 chr11:118965647-11896572 2.21e-01 80 chr19:17008710-17008790 6.19e-01 80 chr12:121647912-12164799 2.43e-01 42_[+3(9.83e-05)]_30 chr1:22055047-22055127 4.38e-01 80 chr3:75761810-75761890 3.36e-02 80 chr5:145531497-145531577 6.58e-01 80 chr13:91611226-91611306 8.85e-02 80 chr7:119317897-119317977 1.42e-03 29_[+1(1.70e-05)]_43 chr3:185543684-185543764 9.56e-01 80 chr1:186330721-186330801 2.01e-02 [+2(6.24e-05)]_72 chr6:119513157-119513237 3.39e-02 80 chr5:81573169-81573249 2.04e-01 80 chr17:39845761-39845841 3.85e-01 80 chr11:34111706-34111786 7.98e-01 80 chr4:184365630-184365710 4.87e-02 55_[+3(4.93e-05)]_17 chr18:23616813-23616893 1.72e-03 4_[+5(9.00e-05)]_1_[+1(8.94e-05)]_\ 59 chr4:146025742-146025822 1.05e-01 80 chr1:206808693-206808773 3.47e-02 14_[+4(9.01e-05)]_58 chr5:145862982-145863062 2.83e-04 24_[+5(3.55e-05)]_37_[+1(1.70e-05)]_\ 3 chr11:5262702-5262782 1.85e-01 80 chr11:46259452-46259532 9.06e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n05.farnam.hpc.yale.internal ********************************************************************************