******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/EP400.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr22:37957894-37957974 1.0000 80 chr8:47529140-47529220 1.0000 80 chr14:58764662-58764742 1.0000 80 chr19:1864283-1864363 1.0000 80 chr16:15670974-15671054 1.0000 80 chrX:65146215-65146295 1.0000 80 chr12:64798772-64798852 1.0000 80 chr12:132345397-13234547 1.0000 80 chr19:2739258-2739338 1.0000 80 chrX:24072738-24072818 1.0000 80 chr7:1781744-1781824 1.0000 80 chr16:20930272-20930352 1.0000 80 chr7:44162925-44163005 1.0000 80 chr17:18684548-18684628 1.0000 80 chrX:110924432-110924512 1.0000 80 chr17:42201280-42201360 1.0000 80 chr11:3425679-3425759 1.0000 80 chr4:57302496-57302576 1.0000 80 chr1:153643392-153643472 1.0000 80 chr1:155579739-155579819 1.0000 80 chr10:120924953-12092503 1.0000 80 chr6:153304494-153304574 1.0000 80 chr1:44495857-44495937 1.0000 80 chr8:37888974-37889054 1.0000 80 chr4:39529425-39529505 1.0000 80 chrX:31881168-31881248 1.0000 80 chrX:48433054-48433134 1.0000 80 chr19:47288093-47288173 1.0000 80 chr16:46917841-46917921 1.0000 80 chr16:4321391-4321471 1.0000 80 chr16:2059963-2060043 1.0000 80 chr12:57848792-57848872 1.0000 80 chr9:139743653-139743733 1.0000 80 chr10:102747300-10274738 1.0000 80 chr7:2144014-2144094 1.0000 80 chr1:110162281-110162361 1.0000 80 chr15:30918274-30918354 1.0000 80 chr2:10260754-10260834 1.0000 80 chr3:135915521-135915601 1.0000 80 chr3:128399765-128399845 1.0000 80 chr7:99933431-99933511 1.0000 80 chr13:27825670-27825750 1.0000 80 chr1:40364863-40364943 1.0000 80 chr6:150284882-150284962 1.0000 80 chr17:8113834-8113914 1.0000 80 chr19:10989956-10990036 1.0000 80 chr6:43739791-43739871 1.0000 80 chr19:54694247-54694327 1.0000 80 chr12:2922007-2922087 1.0000 80 chr14:90849647-90849727 1.0000 80 chr1:90288727-90288807 1.0000 80 chr5:176739270-176739350 1.0000 80 chr22:41682129-41682209 1.0000 80 chr4:109571682-109571762 1.0000 80 chr17:8152641-8152721 1.0000 80 chr19:5773847-5773927 1.0000 80 chr6:151187409-151187489 1.0000 80 chr20:48808938-48809018 1.0000 80 chr3:128968461-128968541 1.0000 80 chr16:30418611-30418691 1.0000 80 chr3:12526094-12526174 1.0000 80 chr1:52522022-52522102 1.0000 80 chr5:175815538-175815618 1.0000 80 chr12:113622999-11362307 1.0000 80 chr4:174255688-174255768 1.0000 80 chr7:97501655-97501735 1.0000 80 chr11:123612278-12361235 1.0000 80 chr14:23398457-23398537 1.0000 80 chr4:140222685-140222765 1.0000 80 chr19:46242892-46242972 1.0000 80 chr16:8159665-8159745 1.0000 80 chr6:126102055-126102135 1.0000 80 chr11:73490459-73490539 1.0000 80 chr12:98910328-98910408 1.0000 80 chr9:100745279-100745359 1.0000 80 chr17:2239667-2239747 1.0000 80 chr9:101984360-101984440 1.0000 80 chr19:57791250-57791330 1.0000 80 chr19:45927098-45927178 1.0000 80 chr19:5903863-5903943 1.0000 80 chr3:167814042-167814122 1.0000 80 chr7:99933759-99933839 1.0000 80 chrX:347759-347839 1.0000 80 chr19:1672497-1672577 1.0000 80 chr16:75681414-75681494 1.0000 80 chr19:40324619-40324699 1.0000 80 chr16:11945274-11945354 1.0000 80 chr13:53226589-53226669 1.0000 80 chr14:50052932-50053012 1.0000 80 chr16:15188015-15188095 1.0000 80 chrX:102942086-102942166 1.0000 80 chr12:10766113-10766193 1.0000 80 chr15:41708952-41709032 1.0000 80 chr3:44379724-44379804 1.0000 80 chr2:232328620-232328700 1.0000 80 chr17:7475870-7475950 1.0000 80 chr6:33359565-33359645 1.0000 80 chr14:59950851-59950931 1.0000 80 chr3:52720066-52720146 1.0000 80 chr12:110906413-11090649 1.0000 80 chr3:99536551-99536631 1.0000 80 chr5:82373115-82373195 1.0000 80 chr19:36706083-36706163 1.0000 80 chr15:55489051-55489131 1.0000 80 chr17:33469253-33469333 1.0000 80 chr3:133524680-133524760 1.0000 80 chr8:101734810-101734890 1.0000 80 chr12:123011338-12301141 1.0000 80 chr19:58331078-58331158 1.0000 80 chr2:70313913-70313993 1.0000 80 chr17:76858316-76858396 1.0000 80 chr1:67896313-67896393 1.0000 80 chr12:22697391-22697471 1.0000 80 chr17:34958050-34958130 1.0000 80 chr15:85114252-85114332 1.0000 80 chr2:68385029-68385109 1.0000 80 chr20:17949341-17949421 1.0000 80 chr8:55047783-55047863 1.0000 80 chr8:30601754-30601834 1.0000 80 chr11:118888970-11888905 1.0000 80 chr2:136742938-136743018 1.0000 80 chr1:70017535-70017615 1.0000 80 chr9:127962932-127963012 1.0000 80 chr6:83902863-83902943 1.0000 80 chr1:150208706-150208786 1.0000 80 chr16:23690045-23690125 1.0000 80 chr6:80714454-80714534 1.0000 80 chr7:50860136-50860216 1.0000 80 chr5:72794348-72794428 1.0000 80 chr2:20251666-20251746 1.0000 80 chr1:76251718-76251798 1.0000 80 chr22:36925070-36925150 1.0000 80 chr3:119182427-119182507 1.0000 80 chr11:59383604-59383684 1.0000 80 chr1:17768030-17768110 1.0000 80 chr2:232571868-232571948 1.0000 80 chr15:32907675-32907755 1.0000 80 chr5:180708426-180708506 1.0000 80 chr2:99771526-99771606 1.0000 80 chr15:50647577-50647657 1.0000 80 chr19:47613247-47613327 1.0000 80 chr7:66460350-66460430 1.0000 80 chr12:21654705-21654785 1.0000 80 chr19:17970866-17970946 1.0000 80 chr6:158034157-158034237 1.0000 80 chr10:18948137-18948217 1.0000 80 chr19:9695112-9695192 1.0000 80 chr1:38061415-38061495 1.0000 80 chr8:42072547-42072627 1.0000 80 chr14:20923382-20923462 1.0000 80 chr13:114770379-11477045 1.0000 80 chr5:133984293-133984373 1.0000 80 chr10:103912406-10391248 1.0000 80 chr20:30135144-30135224 1.0000 80 chr2:122494344-122494424 1.0000 80 chr5:157158475-157158555 1.0000 80 chr6:90529437-90529517 1.0000 80 chr2:88927414-88927494 1.0000 80 chr17:14212447-14212527 1.0000 80 chr1:8938184-8938264 1.0000 80 chr16:74330791-74330871 1.0000 80 chr11:62599411-62599491 1.0000 80 chr2:44588761-44588841 1.0000 80 chr11:118851064-11885114 1.0000 80 chr19:37064027-37064107 1.0000 80 chr15:75165527-75165607 1.0000 80 chr11:46867815-46867895 1.0000 80 chr12:64615952-64616032 1.0000 80 chr3:100120098-100120178 1.0000 80 chr4:56261792-56261872 1.0000 80 chr12:110841376-11084145 1.0000 80 chr4:146019448-146019528 1.0000 80 chr7:65580031-65580111 1.0000 80 chr12:54674650-54674730 1.0000 80 chr12:25102010-25102090 1.0000 80 chr17:76210332-76210412 1.0000 80 chr9:100807817-100807897 1.0000 80 chr6:31588561-31588641 1.0000 80 chr19:46195050-46195130 1.0000 80 chr14:50087129-50087209 1.0000 80 chr16:70557800-70557880 1.0000 80 chr7:56019582-56019662 1.0000 80 chr3:131221702-131221782 1.0000 80 chr9:135545256-135545336 1.0000 80 chr5:114961751-114961831 1.0000 80 chr12:46662595-46662675 1.0000 80 chr1:101491499-101491579 1.0000 80 chr8:99057602-99057682 1.0000 80 chr14:31028416-31028496 1.0000 80 chr12:104324088-10432416 1.0000 80 chr11:107729337-10772941 1.0000 80 chr5:180237336-180237416 1.0000 80 chr6:117996493-117996573 1.0000 80 chr17:38574167-38574247 1.0000 80 chr14:24584105-24584185 1.0000 80 chr21:33765238-33765318 1.0000 80 chr1:244998682-244998762 1.0000 80 chr5:154134496-154134576 1.0000 80 chr12:57881815-57881895 1.0000 80 chr2:127066179-127066259 1.0000 80 chr2:207024721-207024801 1.0000 80 chr8:145023953-145024033 1.0000 80 chr4:120987866-120987946 1.0000 80 chr5:158636781-158636861 1.0000 80 chr6:41889197-41889277 1.0000 80 chr16:4321637-4321717 1.0000 80 chr4:99850059-99850139 1.0000 80 chr19:10217034-10217114 1.0000 80 chr4:95129045-95129125 1.0000 80 chr2:61765471-61765551 1.0000 80 chr20:43540081-43540161 1.0000 80 chr14:65453699-65453779 1.0000 80 chr2:10588927-10589007 1.0000 80 chr7:2394248-2394328 1.0000 80 chr2:175113571-175113651 1.0000 80 chr9:116172771-116172851 1.0000 80 chr16:68027448-68027528 1.0000 80 chr2:73441429-73441509 1.0000 80 chr15:50647371-50647451 1.0000 80 chr6:30585383-30585463 1.0000 80 chr7:127291874-127291954 1.0000 80 chr7:151216955-151217035 1.0000 80 chr8:25316539-25316619 1.0000 80 chr16:31519700-31519780 1.0000 80 chr1:156783708-156783788 1.0000 80 chr16:89555637-89555717 1.0000 80 chr22:32026611-32026691 1.0000 80 chr10:25305778-25305858 1.0000 80 chrX:100646009-100646089 1.0000 80 chr6:111303246-111303326 1.0000 80 chr19:58898223-58898303 1.0000 80 chr3:150264715-150264795 1.0000 80 chr2:75062127-75062207 1.0000 80 chr12:93861410-93861490 1.0000 80 chr16:4475460-4475540 1.0000 80 chr5:138940547-138940627 1.0000 80 chr17:79895334-79895414 1.0000 80 chr1:161147430-161147510 1.0000 80 chr17:61904870-61904950 1.0000 80 chr12:124068946-12406902 1.0000 80 chr17:79259296-79259376 1.0000 80 chr11:14541791-14541871 1.0000 80 chr5:162887035-162887115 1.0000 80 chr15:66874526-66874606 1.0000 80 chr4:40240505-40240585 1.0000 80 chr2:74426224-74426304 1.0000 80 chr15:91537734-91537814 1.0000 80 chr12:58165778-58165858 1.0000 80 chr10:30841247-30841327 1.0000 80 chr19:40476712-40476792 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_EP400/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/EP400.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.187 C 0.311 G 0.313 T 0.189 Background letter frequencies (from file dataset with add-one prior applied): A 0.187 C 0.311 G 0.313 T 0.189 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TTGCATCA MEME-1 width = 8 sites = 18 llr = 186 E-value = 1.9e-006 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTGCATCA MEME-1 Description -------------------------------------------------------------------------------- Simplified A ::1:9::a pos.-specific C ::1a::9: probability G ::8:111: matrix T aa1::9:: bits 2.4 ** * 2.2 ** * 1.9 ** ** * 1.7 ** *** * Relative 1.5 ** ***** Entropy 1.2 ** ***** (14.9 bits) 1.0 ** ***** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TTGCATCA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGCATCA MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr12:57881815-57881895 32 7.15e-06 CCGGTTCCGG TTGCATCA GCGAGGGATT chr12:25102010-25102090 66 7.15e-06 ACCTAGCGGA TTGCATCA GCAGGAA chr8:42072547-42072627 2 7.15e-06 C TTGCATCA GTTCTGGTTA chr19:47613247-47613327 19 7.15e-06 TGTAACACGT TTGCATCA ACTTTTCACA chr1:17768030-17768110 42 7.15e-06 TAATATCATA TTGCATCA TCTGATCCTA chr19:5773847-5773927 23 7.15e-06 TACAAAGAGA TTGCATCA GTCCACGTGT chr12:57848792-57848872 68 7.15e-06 ATCCTCTTTC TTGCATCA TGCGT chr19:47288093-47288173 68 7.15e-06 CCTGGACAGC TTGCATCA GCCAC chrX:24072738-24072818 41 7.15e-06 GCGCGCCGGG TTGCATCA CCCGCCTCGC chr12:132345397-13234547 38 7.15e-06 CTCGCCCTGG TTGCATCA CCCAGGACGC chr19:57791250-57791330 27 1.14e-05 GCGAAGCCTA TTACATCA CCCGGAAGTC chr1:44495857-44495937 73 1.14e-05 GGCACGGGCG TTACATCA chr12:64798772-64798852 47 1.57e-05 TTGCTTGGTG TTTCATCA CCCGAATTGC chr5:157158475-157158555 21 3.48e-05 TGGCCACCAT TTCCATCA CTCTGAGACG chr7:2144014-2144094 45 3.48e-05 AGGCGGCCTG TTGCGTCA GATCCCTGAC chr22:37957894-37957974 49 3.48e-05 AAACTTGTTC TTGCGTCA TTCCCACCAT chr8:37888974-37889054 58 4.20e-05 ACGCGCCTGT TTGCATGA TGAAATAAAT chr17:18684548-18684628 62 5.38e-05 GGCCGCCATG TTGCAGCA GGTGAGGGGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGCATCA MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:57881815-57881895 7.1e-06 31_[+1]_41 chr12:25102010-25102090 7.1e-06 65_[+1]_7 chr8:42072547-42072627 7.1e-06 1_[+1]_71 chr19:47613247-47613327 7.1e-06 18_[+1]_54 chr1:17768030-17768110 7.1e-06 41_[+1]_31 chr19:5773847-5773927 7.1e-06 22_[+1]_50 chr12:57848792-57848872 7.1e-06 67_[+1]_5 chr19:47288093-47288173 7.1e-06 67_[+1]_5 chrX:24072738-24072818 7.1e-06 40_[+1]_32 chr12:132345397-13234547 7.1e-06 37_[+1]_35 chr19:57791250-57791330 1.1e-05 26_[+1]_46 chr1:44495857-44495937 1.1e-05 72_[+1] chr12:64798772-64798852 1.6e-05 46_[+1]_26 chr5:157158475-157158555 3.5e-05 20_[+1]_52 chr7:2144014-2144094 3.5e-05 44_[+1]_28 chr22:37957894-37957974 3.5e-05 48_[+1]_24 chr8:37888974-37889054 4.2e-05 57_[+1]_15 chr17:18684548-18684628 5.4e-05 61_[+1]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGCATCA MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTGCATCA width=8 seqs=18 chr12:57881815-57881895 ( 32) TTGCATCA 1 chr12:25102010-25102090 ( 66) TTGCATCA 1 chr8:42072547-42072627 ( 2) TTGCATCA 1 chr19:47613247-47613327 ( 19) TTGCATCA 1 chr1:17768030-17768110 ( 42) TTGCATCA 1 chr19:5773847-5773927 ( 23) TTGCATCA 1 chr12:57848792-57848872 ( 68) TTGCATCA 1 chr19:47288093-47288173 ( 68) TTGCATCA 1 chrX:24072738-24072818 ( 41) TTGCATCA 1 chr12:132345397-13234547 ( 38) TTGCATCA 1 chr19:57791250-57791330 ( 27) TTACATCA 1 chr1:44495857-44495937 ( 73) TTACATCA 1 chr12:64798772-64798852 ( 47) TTTCATCA 1 chr5:157158475-157158555 ( 21) TTCCATCA 1 chr7:2144014-2144094 ( 45) TTGCGTCA 1 chr22:37957894-37957974 ( 49) TTGCGTCA 1 chr8:37888974-37889054 ( 58) TTGCATGA 1 chr17:18684548-18684628 ( 62) TTGCAGCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGCATCA MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.8329 E= 1.9e-006 -1081 -1081 -1081 240 -1081 -1081 -1081 240 -75 -248 131 -177 -1081 168 -1081 -1081 225 -1081 -149 -1081 -1081 -1081 -249 232 -1081 160 -249 -1081 242 -1081 -1081 -1081 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGCATCA MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 18 E= 1.9e-006 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.111111 0.055556 0.777778 0.055556 0.000000 1.000000 0.000000 0.000000 0.888889 0.000000 0.111111 0.000000 0.000000 0.000000 0.055556 0.944444 0.000000 0.944444 0.055556 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTGCATCA MEME-1 regular expression -------------------------------------------------------------------------------- TTGCATCA -------------------------------------------------------------------------------- Time 5.60 secs. ******************************************************************************** ******************************************************************************** MOTIF MCACGTGG MEME-2 width = 8 sites = 31 llr = 258 E-value = 1.4e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif MCACGTGG MEME-2 Description -------------------------------------------------------------------------------- Simplified A 3:a:2::: pos.-specific C 6a:9:::1 probability G 1:::8:a8 matrix T :::1:a:1 bits 2.4 * * 2.2 * * 1.9 * * 1.7 ** ** Relative 1.5 ** ** Entropy 1.2 ****** (12.0 bits) 1.0 ****** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CCACGTGG consensus A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MCACGTGG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:156783708-156783788 42 3.26e-05 TCGCCCAGCA CCACGTGG CGCCCGTCCC chr2:10588927-10589007 13 3.26e-05 GATGTGCTGG CCACGTGG GCCCCGCCGG chr3:131221702-131221782 41 3.26e-05 CACGCCACCG CCACGTGG ACGCAGTAGC chr19:37064027-37064107 62 3.26e-05 GCTCCCGGCT CCACGTGG ACCGACCTCG chr8:55047783-55047863 5 3.26e-05 GAGA CCACGTGG CCTCCGAGCA chr17:33469253-33469333 51 3.26e-05 TCCTGCGTCC CCACGTGG AGGAGAAAGA chr17:79895334-79895414 68 5.22e-05 CCCGGGACCT ACACGTGG GGTCC chr12:25102010-25102090 5 5.22e-05 GAGT ACACGTGG CGGGCTGGAT chr6:90529437-90529517 43 5.22e-05 GAGGGGCACC ACACGTGG GTGAGCACAC chr1:70017535-70017615 31 5.22e-05 tccttactgt acacgtgg ctggccaaga chr19:57791250-57791330 4 5.22e-05 tcc aCACGTGG CGAACGCGAA chr16:8159665-8159745 30 5.22e-05 tctttattgt acacgtgg ctgacaaaga chrX:65146215-65146295 5 5.22e-05 ctac acacgtgg ggatatgtgg chr21:33765238-33765318 71 7.17e-05 CGCTTCAGGC CCACATgg cg chr9:100807817-100807897 55 7.17e-05 ccttcttcca ccacatgg ctgtgctaga chr19:46242892-46242972 47 7.17e-05 cccctccgaa ccacatgg actgagaatg chr16:20930272-20930352 14 7.17e-05 AATTTCCAAG CCACATGG ACCCAGACTT chr15:50647371-50647451 12 8.34e-05 GCGCGGAGGG ACACATGG TGTGCGAGTG chr10:30841247-30841327 19 1.03e-04 cttttgtcag ccacgtgt ccagtaagaa chr19:5773847-5773927 33 1.03e-04 TTGCATCAGT CCACGTGT ATCTTCCCGG chr6:158034157-158034237 11 1.15e-04 GACGCAACCT ACACGTGT ATTTATCTAC chr15:66874526-66874606 49 2.00e-04 acctccccag ccatgtgg aactgtaagt chr2:75062127-75062207 20 2.00e-04 TCCGGCGAGA GCACGTGG AGAGAATCGT chr6:41889197-41889277 67 2.00e-04 TCTTCAGTCC CCACGTGC GATCCT chr12:110841376-11084145 35 2.00e-04 GCCATGTCCC GCACGTGG TCTATCACAT chr3:167814042-167814122 47 2.00e-04 CGTTCGGAAC GCACGTGG AGAGCGGAGT chr6:151187409-151187489 58 2.00e-04 ACGCCCGGCT CCACGTGC GCAGCCGGCC chr1:90288727-90288807 42 2.00e-04 CCTTCCATTA CCATGTGG AGTAGCATAT chr1:40364863-40364943 45 2.00e-04 TTGTTCCAGG CCATGTGG CCTGTGAGTG chr4:57302496-57302576 60 2.00e-04 GAGCTCGCGG CCACGTGC GAGCCGCGAA chr5:158636781-158636861 22 2.31e-04 CCATTCTGAC ACACGTGC TCTCTCACTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MCACGTGG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:156783708-156783788 3.3e-05 41_[+2]_31 chr2:10588927-10589007 3.3e-05 12_[+2]_60 chr3:131221702-131221782 3.3e-05 40_[+2]_32 chr19:37064027-37064107 3.3e-05 61_[+2]_11 chr8:55047783-55047863 3.3e-05 4_[+2]_68 chr17:33469253-33469333 3.3e-05 50_[+2]_22 chr17:79895334-79895414 5.2e-05 67_[+2]_5 chr12:25102010-25102090 5.2e-05 4_[+2]_68 chr6:90529437-90529517 5.2e-05 42_[+2]_30 chr1:70017535-70017615 5.2e-05 30_[+2]_42 chr19:57791250-57791330 5.2e-05 3_[+2]_69 chr16:8159665-8159745 5.2e-05 29_[+2]_43 chrX:65146215-65146295 5.2e-05 4_[+2]_68 chr21:33765238-33765318 7.2e-05 70_[+2]_2 chr9:100807817-100807897 7.2e-05 54_[+2]_18 chr19:46242892-46242972 7.2e-05 46_[+2]_26 chr16:20930272-20930352 7.2e-05 13_[+2]_59 chr15:50647371-50647451 8.3e-05 11_[+2]_61 chr10:30841247-30841327 0.0001 18_[+2]_54 chr19:5773847-5773927 0.0001 32_[+2]_40 chr6:158034157-158034237 0.00011 10_[+2]_62 chr15:66874526-66874606 0.0002 48_[+2]_24 chr2:75062127-75062207 0.0002 19_[+2]_53 chr6:41889197-41889277 0.0002 66_[+2]_6 chr12:110841376-11084145 0.0002 34_[+2]_38 chr3:167814042-167814122 0.0002 46_[+2]_26 chr6:151187409-151187489 0.0002 57_[+2]_15 chr1:90288727-90288807 0.0002 41_[+2]_31 chr1:40364863-40364943 0.0002 44_[+2]_28 chr4:57302496-57302576 0.0002 59_[+2]_13 chr5:158636781-158636861 0.00023 21_[+2]_51 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MCACGTGG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF MCACGTGG width=8 seqs=31 chr1:156783708-156783788 ( 42) CCACGTGG 1 chr2:10588927-10589007 ( 13) CCACGTGG 1 chr3:131221702-131221782 ( 41) CCACGTGG 1 chr19:37064027-37064107 ( 62) CCACGTGG 1 chr8:55047783-55047863 ( 5) CCACGTGG 1 chr17:33469253-33469333 ( 51) CCACGTGG 1 chr17:79895334-79895414 ( 68) ACACGTGG 1 chr12:25102010-25102090 ( 5) ACACGTGG 1 chr6:90529437-90529517 ( 43) ACACGTGG 1 chr1:70017535-70017615 ( 31) ACACGTGG 1 chr19:57791250-57791330 ( 4) ACACGTGG 1 chr16:8159665-8159745 ( 30) ACACGTGG 1 chrX:65146215-65146295 ( 5) ACACGTGG 1 chr21:33765238-33765318 ( 71) CCACATGG 1 chr9:100807817-100807897 ( 55) CCACATGG 1 chr19:46242892-46242972 ( 47) CCACATGG 1 chr16:20930272-20930352 ( 14) CCACATGG 1 chr15:50647371-50647451 ( 12) ACACATGG 1 chr10:30841247-30841327 ( 19) CCACGTGT 1 chr19:5773847-5773927 ( 33) CCACGTGT 1 chr6:158034157-158034237 ( 11) ACACGTGT 1 chr15:66874526-66874606 ( 49) CCATGTGG 1 chr2:75062127-75062207 ( 20) GCACGTGG 1 chr6:41889197-41889277 ( 67) CCACGTGC 1 chr12:110841376-11084145 ( 35) GCACGTGG 1 chr3:167814042-167814122 ( 47) GCACGTGG 1 chr6:151187409-151187489 ( 58) CCACGTGC 1 chr1:90288727-90288807 ( 42) CCATGTGG 1 chr1:40364863-40364943 ( 45) CCATGTGG 1 chr4:57302496-57302576 ( 60) CCACGTGC 1 chr5:158636781-158636861 ( 22) ACACGTGC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MCACGTGG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.30809 E= 1.4e+002 79 90 -169 -1160 -1160 169 -1160 -1160 242 -1160 -1160 -1160 -1160 154 -1160 -97 -21 -1160 142 -1160 -1160 -1160 -1160 240 -1160 -1160 168 -1160 -1160 -127 131 -97 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MCACGTGG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 31 E= 1.4e+002 0.322581 0.580645 0.096774 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.903226 0.000000 0.096774 0.161290 0.000000 0.838710 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.129032 0.774194 0.096774 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MCACGTGG MEME-2 regular expression -------------------------------------------------------------------------------- [CA]CACGTGG -------------------------------------------------------------------------------- Time 9.41 secs. ******************************************************************************** ******************************************************************************** MOTIF TGATGMAA MEME-3 width = 8 sites = 11 llr = 115 E-value = 1.8e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGATGMAA MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::8:16aa pos.-specific C :::::4:: probability G :92:9::: matrix T a1:a:::: bits 2.4 * * ** 2.2 * * ** 1.9 * * ** 1.7 * ** ** Relative 1.5 * ** ** Entropy 1.2 ******** (15.1 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TGATGAAA consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGATGMAA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr16:89555637-89555717 60 4.28e-06 TGCCAGGGGA TGATGAAA TGAGGAACGG chr16:46917841-46917921 32 4.28e-06 TGGCCTTGGA TGATGAAA CTCGGGGCGA chr8:37888974-37889054 37 4.28e-06 GCACAGACGC TGATGAAA CCTACGCGCC chr1:17768030-17768110 16 1.14e-05 TCAGACACAC TGATGCAA TGAGACGCTA chr1:90288727-90288807 59 1.14e-05 GAGTAGCATA TGATGCAA CACTTAAAGT chr16:20930272-20930352 56 1.14e-05 CATCTGGTGC TGATGCAA TCCTAGCTCA chr19:2739258-2739338 17 1.14e-05 GCATTTTACC TGATGCAA TGGGCCAAAG chr15:66874526-66874606 32 1.65e-05 tctgccatga ttatgaaa cctccccagc chr13:53226589-53226669 1 1.65e-05 . TGATAAAA ACTAGGGAAA chr1:38061415-38061495 52 2.37e-05 CCGGCTTACG TGGTGAAA CAAACTTTTA chr3:135915521-135915601 23 2.37e-05 ATGTGGGCTG TGGTGAAA CATTCGTTAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGATGMAA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr16:89555637-89555717 4.3e-06 59_[+3]_13 chr16:46917841-46917921 4.3e-06 31_[+3]_41 chr8:37888974-37889054 4.3e-06 36_[+3]_36 chr1:17768030-17768110 1.1e-05 15_[+3]_57 chr1:90288727-90288807 1.1e-05 58_[+3]_14 chr16:20930272-20930352 1.1e-05 55_[+3]_17 chr19:2739258-2739338 1.1e-05 16_[+3]_56 chr15:66874526-66874606 1.7e-05 31_[+3]_41 chr13:53226589-53226669 1.7e-05 [+3]_72 chr1:38061415-38061495 2.4e-05 51_[+3]_21 chr3:135915521-135915601 2.4e-05 22_[+3]_50 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGATGMAA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGATGMAA width=8 seqs=11 chr16:89555637-89555717 ( 60) TGATGAAA 1 chr16:46917841-46917921 ( 32) TGATGAAA 1 chr8:37888974-37889054 ( 37) TGATGAAA 1 chr1:17768030-17768110 ( 16) TGATGCAA 1 chr1:90288727-90288807 ( 59) TGATGCAA 1 chr16:20930272-20930352 ( 56) TGATGCAA 1 chr19:2739258-2739338 ( 17) TGATGCAA 1 chr15:66874526-66874606 ( 32) TTATGAAA 1 chr13:53226589-53226669 ( 1) TGATAAAA 1 chr1:38061415-38061495 ( 52) TGGTGAAA 1 chr3:135915521-135915601 ( 23) TGGTGAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGATGMAA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.0506 E= 1.8e+002 -1010 -1010 -1010 240 -1010 -1010 154 -106 213 -1010 -78 -1010 -1010 -1010 -1010 240 -104 -1010 154 -1010 177 23 -1010 -1010 242 -1010 -1010 -1010 242 -1010 -1010 -1010 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGATGMAA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 11 E= 1.8e+002 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.909091 0.090909 0.818182 0.000000 0.181818 0.000000 0.000000 0.000000 0.000000 1.000000 0.090909 0.000000 0.909091 0.000000 0.636364 0.363636 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGATGMAA MEME-3 regular expression -------------------------------------------------------------------------------- TGATG[AC]AA -------------------------------------------------------------------------------- Time 13.16 secs. ******************************************************************************** ******************************************************************************** MOTIF ARRDGAAR MEME-4 width = 8 sites = 38 llr = 303 E-value = 1.0e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif ARRDGAAR MEME-4 Description -------------------------------------------------------------------------------- Simplified A a6332aa4 pos.-specific C ::2::::: probability G :4548::6 matrix T :::2:::: bits 2.4 * ** 2.2 * ** 1.9 * ** 1.7 * ** Relative 1.5 * ** Entropy 1.2 ** *** (11.5 bits) 1.0 ** **** 0.7 ** **** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AAGGGAAG consensus GAAA A sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRDGAAR MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr20:43540081-43540161 48 1.37e-05 caacaaacaa aaaaGAAA CAACAACGAA chr1:70017535-70017615 50 1.37e-05 tggccaagag aagagaag atggagcggc chr16:8159665-8159745 44 1.37e-05 gtggctgaca aagagaag ggaagatggt chr16:15670974-15671054 25 1.37e-05 atggctggca aagagaag ggagcgtgga chr19:45927098-45927178 2 2.49e-05 C AAGGGAAA GACTGCAGAG chr10:18948137-18948217 27 4.51e-05 CTCCTACCGG AAGTGAAA CCGAAGAAAA chr4:140222685-140222765 59 4.51e-05 GTTAAGTGAG AAAGGAAA AAAGACAACG chr12:2922007-2922087 68 4.51e-05 GGGACGGGGC AAGGGAAG TGGAA chr3:150264715-150264795 66 6.17e-05 TGGCAATCGG AAGTGAAG TCTCCGC chr4:146019448-146019528 61 6.17e-05 TGTGGCTGAA AAGTGAAG GCAAGAGCTG chr4:56261792-56261872 60 6.17e-05 GAGGAAGCAG AAGTGAAG GACCTCGCAG chr2:88927414-88927494 8 6.17e-05 CTGTCCC AAGTGAAG AGTGGGAGGC chr9:101984360-101984440 54 6.17e-05 GTTGTGATCC AAAGGAAG GAGGCCGGAG chr19:2739258-2739338 32 6.17e-05 CAATGGGCCA AAGTGAAG TCGGTTTCAC chr6:30585383-30585463 52 7.41e-05 GTGACTGGCC AAAAAAAA CCGCAATTTT chr2:20251666-20251746 21 7.41e-05 TGAGACCCGC AAGAAAAG AGGCATTTAA chr17:33469253-33469333 59 8.78e-05 CCCCACGTGG AGGAGAAA GAGCCCGGCA chr15:55489051-55489131 10 8.78e-05 TGGGCCCCG AACAGAAA TAACACTTTT chr19:46242892-46242972 66 8.78e-05 ctgagaatgg aggagaaa tggttgc chr5:180708426-180708506 34 1.15e-04 ttagaggacc aggagaag ggggagctgg chr16:89555637-89555717 73 1.63e-04 TGAAATGAGG AACGGAAA chr15:50647577-50647657 20 1.63e-04 TCAGCCACAC AAAGAAAG CGGCGGAATG chrX:24072738-24072818 2 1.63e-04 A AACGGAAA TGGTCTCTCC chr4:99850059-99850139 67 2.15e-04 TCCAACATGA AGGGGAAG GGGCGG chr3:12526094-12526174 18 2.15e-04 CCAGGGCGAG AGAGGAAA GGGCCTAGGT chr1:90288727-90288807 5 2.15e-04 TTGG AGAGGAAA CTGTCCTTAG chr6:150284882-150284962 25 2.15e-04 CCATGGAAGG AACGGAAG GAACGGCGTC chrX:48433054-48433134 53 2.15e-04 CCGTGCTTGG AGGTGAAA CATTTCGGTT chr11:107729337-10772941 48 2.50e-04 TCCACTCACC AGGTGAAG AGTTTGCCTT chr13:114770379-11477045 39 2.50e-04 tccaccatca agaggaag gaaatcttat chrX:102942086-102942166 8 2.50e-04 CACTGGG AGAGGAAG TGTCTACGTG chr1:153643392-153643472 68 2.50e-04 AGTAGCAGAC AACTGAAG AGGCG chr4:120987866-120987946 37 2.77e-04 CAGGGACACA AACAAAAG CACGCGCTTC chr2:122494344-122494424 68 2.88e-04 CAGCCGGGCC AGAAAAAG TCGCC chr12:123011338-12301141 13 2.88e-04 GTTGGAACGT AGCAGAAA AATATCCCTG chr13:53226589-53226669 12 3.11e-04 GATAAAAACT AGGGAAAA TGGGAGCTCG chr1:101491499-101491579 51 3.41e-04 TCATAGCCTC AGGGAAAG GATCGGGCGT chr10:103912406-10391248 28 3.73e-04 GGCAGTGACC AGAGAAAG CCTGCGGCCT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRDGAAR MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr20:43540081-43540161 1.4e-05 47_[+4]_25 chr1:70017535-70017615 1.4e-05 49_[+4]_23 chr16:8159665-8159745 1.4e-05 43_[+4]_29 chr16:15670974-15671054 1.4e-05 24_[+4]_48 chr19:45927098-45927178 2.5e-05 1_[+4]_71 chr10:18948137-18948217 4.5e-05 26_[+4]_46 chr4:140222685-140222765 4.5e-05 58_[+4]_14 chr12:2922007-2922087 4.5e-05 67_[+4]_5 chr3:150264715-150264795 6.2e-05 65_[+4]_7 chr4:146019448-146019528 6.2e-05 60_[+4]_12 chr4:56261792-56261872 6.2e-05 59_[+4]_13 chr2:88927414-88927494 6.2e-05 7_[+4]_65 chr9:101984360-101984440 6.2e-05 53_[+4]_19 chr19:2739258-2739338 6.2e-05 31_[+4]_41 chr6:30585383-30585463 7.4e-05 51_[+4]_21 chr2:20251666-20251746 7.4e-05 20_[+4]_52 chr17:33469253-33469333 8.8e-05 58_[+4]_14 chr15:55489051-55489131 8.8e-05 9_[+4]_63 chr19:46242892-46242972 8.8e-05 65_[+4]_7 chr5:180708426-180708506 0.00011 33_[+4]_39 chr16:89555637-89555717 0.00016 72_[+4] chr15:50647577-50647657 0.00016 19_[+4]_53 chrX:24072738-24072818 0.00016 1_[+4]_71 chr4:99850059-99850139 0.00021 66_[+4]_6 chr3:12526094-12526174 0.00021 17_[+4]_55 chr1:90288727-90288807 0.00021 4_[+4]_68 chr6:150284882-150284962 0.00021 24_[+4]_48 chrX:48433054-48433134 0.00021 52_[+4]_20 chr11:107729337-10772941 0.00025 47_[+4]_25 chr13:114770379-11477045 0.00025 38_[+4]_34 chrX:102942086-102942166 0.00025 7_[+4]_65 chr1:153643392-153643472 0.00025 67_[+4]_5 chr4:120987866-120987946 0.00028 36_[+4]_36 chr2:122494344-122494424 0.00029 67_[+4]_5 chr12:123011338-12301141 0.00029 12_[+4]_60 chr13:53226589-53226669 0.00031 11_[+4]_61 chr1:101491499-101491579 0.00034 50_[+4]_22 chr10:103912406-10391248 0.00037 27_[+4]_45 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRDGAAR MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ARRDGAAR width=8 seqs=38 chr20:43540081-43540161 ( 48) AAAAGAAA 1 chr1:70017535-70017615 ( 50) AAGAGAAG 1 chr16:8159665-8159745 ( 44) AAGAGAAG 1 chr16:15670974-15671054 ( 25) AAGAGAAG 1 chr19:45927098-45927178 ( 2) AAGGGAAA 1 chr10:18948137-18948217 ( 27) AAGTGAAA 1 chr4:140222685-140222765 ( 59) AAAGGAAA 1 chr12:2922007-2922087 ( 68) AAGGGAAG 1 chr3:150264715-150264795 ( 66) AAGTGAAG 1 chr4:146019448-146019528 ( 61) AAGTGAAG 1 chr4:56261792-56261872 ( 60) AAGTGAAG 1 chr2:88927414-88927494 ( 8) AAGTGAAG 1 chr9:101984360-101984440 ( 54) AAAGGAAG 1 chr19:2739258-2739338 ( 32) AAGTGAAG 1 chr6:30585383-30585463 ( 52) AAAAAAAA 1 chr2:20251666-20251746 ( 21) AAGAAAAG 1 chr17:33469253-33469333 ( 59) AGGAGAAA 1 chr15:55489051-55489131 ( 10) AACAGAAA 1 chr19:46242892-46242972 ( 66) AGGAGAAA 1 chr5:180708426-180708506 ( 34) AGGAGAAG 1 chr16:89555637-89555717 ( 73) AACGGAAA 1 chr15:50647577-50647657 ( 20) AAAGAAAG 1 chrX:24072738-24072818 ( 2) AACGGAAA 1 chr4:99850059-99850139 ( 67) AGGGGAAG 1 chr3:12526094-12526174 ( 18) AGAGGAAA 1 chr1:90288727-90288807 ( 5) AGAGGAAA 1 chr6:150284882-150284962 ( 25) AACGGAAG 1 chrX:48433054-48433134 ( 53) AGGTGAAA 1 chr11:107729337-10772941 ( 48) AGGTGAAG 1 chr13:114770379-11477045 ( 39) AGAGGAAG 1 chrX:102942086-102942166 ( 8) AGAGGAAG 1 chr1:153643392-153643472 ( 68) AACTGAAG 1 chr4:120987866-120987946 ( 37) AACAAAAG 1 chr2:122494344-122494424 ( 68) AGAAAAAG 1 chr12:123011338-12301141 ( 13) AGCAGAAA 1 chr13:53226589-53226669 ( 12) AGGGAAAA 1 chr1:101491499-101491579 ( 51) AGGGAAAG 1 chr10:103912406-10391248 ( 28) AGAGAAAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRDGAAR MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.3471 E= 1.0e+002 242 -1189 -1189 -1189 169 -1189 33 -1189 63 -75 75 -1189 87 -1189 43 32 17 -1189 133 -1189 242 -1189 -1189 -1189 242 -1189 -1189 -1189 108 -1189 95 -1189 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRDGAAR MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 38 E= 1.0e+002 1.000000 0.000000 0.000000 0.000000 0.605263 0.000000 0.394737 0.000000 0.289474 0.184211 0.526316 0.000000 0.342105 0.000000 0.421053 0.236842 0.210526 0.000000 0.789474 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.394737 0.000000 0.605263 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARRDGAAR MEME-4 regular expression -------------------------------------------------------------------------------- A[AG][GA][GAT][GA]AA[GA] -------------------------------------------------------------------------------- Time 16.89 secs. ******************************************************************************** ******************************************************************************** MOTIF GCCATYYT MEME-5 width = 8 sites = 18 llr = 166 E-value = 1.8e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif GCCATYYT MEME-5 Description -------------------------------------------------------------------------------- Simplified A :1:9:::: pos.-specific C :9a::44: probability G 8::::::: matrix T 2::1a66a bits 2.4 * * 2.2 * * 1.9 ** * 1.7 *** * Relative 1.5 **** * Entropy 1.2 ******** (13.3 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel GCCATTTT consensus CC sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATYYT MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr4:146019448-146019528 18 7.22e-06 GCTGGGCACC GCCATTTT GGCCGGTGGC chr1:70017535-70017615 66 7.22e-06 agatggagcg gccatttt gatcatg chr12:10766113-10766193 14 7.22e-06 GCTAGCCACA GCCATTTT TGTACCCGGG chr16:15670974-15671054 46 7.22e-06 gcgtggagcc gccatttt gaacatacct chr17:79259296-79259376 36 3.10e-05 GGAAGGAGCC GCCATTCT CTCCGCCCTG chr7:151216955-151217035 53 3.10e-05 TTTTAATTAC GCCATTCT CCCCGAGCGC chr5:158636781-158636861 11 3.10e-05 TGTGACAGGC GCCATTCT GACACACGTG chr2:232571868-232571948 50 3.10e-05 CCTACGTCTC GCCATCTT GTGTGTGGCA chr2:70313913-70313993 4 3.10e-05 GAC GCCATTCT TTTTAGGACC chr16:8159665-8159745 6 3.10e-05 tcggt gccatctt ctctgctctt chr13:27825670-27825750 41 3.10e-05 GGCCGGAACC GCCATCTT CCAGGTAGGG chr1:8938184-8938264 21 3.54e-05 GCCGCCCTCC TCCATTTT AGGAAGGGCC chr4:99850059-99850139 15 5.49e-05 CGCCGCCTCG GCCATCCT CCGGGACGTC chr17:33469253-33469333 37 5.49e-05 CACTGCTGCC GCCATCCT GCGTCCCCAC chr14:65453699-65453779 8 7.66e-05 ATTGCCC TCCATCTT CCTCCCCCGT chr6:41889197-41889277 52 1.05e-04 GCGCATCCTG GCCTTTCT TCAGTCCCCA chr2:122494344-122494424 23 1.35e-04 TTTGAAACTC GACATCTT CCTGCGGATT chr3:99536551-99536631 2 1.35e-04 T TCCTTTTT GTCTTTAAGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATYYT MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:146019448-146019528 7.2e-06 17_[+5]_55 chr1:70017535-70017615 7.2e-06 65_[+5]_7 chr12:10766113-10766193 7.2e-06 13_[+5]_59 chr16:15670974-15671054 7.2e-06 45_[+5]_27 chr17:79259296-79259376 3.1e-05 35_[+5]_37 chr7:151216955-151217035 3.1e-05 52_[+5]_20 chr5:158636781-158636861 3.1e-05 10_[+5]_62 chr2:232571868-232571948 3.1e-05 49_[+5]_23 chr2:70313913-70313993 3.1e-05 3_[+5]_69 chr16:8159665-8159745 3.1e-05 5_[+5]_67 chr13:27825670-27825750 3.1e-05 40_[+5]_32 chr1:8938184-8938264 3.5e-05 20_[+5]_52 chr4:99850059-99850139 5.5e-05 14_[+5]_58 chr17:33469253-33469333 5.5e-05 36_[+5]_36 chr14:65453699-65453779 7.7e-05 7_[+5]_65 chr6:41889197-41889277 0.0001 51_[+5]_21 chr2:122494344-122494424 0.00014 22_[+5]_50 chr3:99536551-99536631 0.00014 1_[+5]_71 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATYYT MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GCCATYYT width=8 seqs=18 chr4:146019448-146019528 ( 18) GCCATTTT 1 chr1:70017535-70017615 ( 66) GCCATTTT 1 chr12:10766113-10766193 ( 14) GCCATTTT 1 chr16:15670974-15671054 ( 46) GCCATTTT 1 chr17:79259296-79259376 ( 36) GCCATTCT 1 chr7:151216955-151217035 ( 53) GCCATTCT 1 chr5:158636781-158636861 ( 11) GCCATTCT 1 chr2:232571868-232571948 ( 50) GCCATCTT 1 chr2:70313913-70313993 ( 4) GCCATTCT 1 chr16:8159665-8159745 ( 6) GCCATCTT 1 chr13:27825670-27825750 ( 41) GCCATCTT 1 chr1:8938184-8938264 ( 21) TCCATTTT 1 chr4:99850059-99850139 ( 15) GCCATCCT 1 chr17:33469253-33469333 ( 37) GCCATCCT 1 chr14:65453699-65453779 ( 8) TCCATCTT 1 chr6:41889197-41889277 ( 52) GCCTTTCT 1 chr2:122494344-122494424 ( 23) GACATCTT 1 chr3:99536551-99536631 ( 2) TCCTTTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATYYT MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.1187 E= 1.8e+003 -1081 -1081 141 -18 -175 160 -1081 -1081 -1081 168 -1081 -1081 225 -1081 -1081 -77 -1081 -1081 -1081 240 -1081 32 -1081 169 -1081 32 -1081 169 -1081 -1081 -1081 240 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATYYT MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 18 E= 1.8e+003 0.000000 0.000000 0.833333 0.166667 0.055556 0.944444 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.888889 0.000000 0.000000 0.111111 0.000000 0.000000 0.000000 1.000000 0.000000 0.388889 0.000000 0.611111 0.000000 0.388889 0.000000 0.611111 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATYYT MEME-5 regular expression -------------------------------------------------------------------------------- GCCAT[TC][TC]T -------------------------------------------------------------------------------- Time 20.46 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:37957894-37957974 1.48e-01 48_[+1(3.48e-05)]_24 chr8:47529140-47529220 8.74e-01 80 chr14:58764662-58764742 3.64e-01 80 chr19:1864283-1864363 9.56e-01 80 chr16:15670974-15671054 5.42e-06 10_[+2(8.34e-05)]_6_[+4(1.37e-05)]_\ 13_[+5(7.22e-06)]_27 chrX:65146215-65146295 3.35e-03 4_[+2(5.22e-05)]_68 chr12:64798772-64798852 1.50e-02 46_[+1(1.57e-05)]_26 chr12:132345397-13234547 4.50e-02 37_[+1(7.15e-06)]_35 chr19:2739258-2739338 3.88e-04 16_[+3(1.14e-05)]_7_[+4(6.17e-05)]_\ 41 chrX:24072738-24072818 3.71e-03 40_[+1(7.15e-06)]_32 chr7:1781744-1781824 7.28e-01 80 chr16:20930272-20930352 5.56e-04 13_[+2(7.17e-05)]_34_[+3(1.14e-05)]_\ 17 chr7:44162925-44163005 8.64e-01 80 chr17:18684548-18684628 2.70e-03 61_[+1(5.38e-05)]_11 chrX:110924432-110924512 6.61e-01 80 chr17:42201280-42201360 3.93e-03 27_[+3(7.38e-05)]_45 chr11:3425679-3425759 2.32e-01 80 chr4:57302496-57302576 4.05e-01 80 chr1:153643392-153643472 5.70e-02 80 chr1:155579739-155579819 3.11e-01 80 chr10:120924953-12092503 8.71e-01 80 chr6:153304494-153304574 6.59e-02 80 chr1:44495857-44495937 3.69e-02 72_[+1(1.14e-05)] chr8:37888974-37889054 7.02e-05 36_[+3(4.28e-06)]_18_[+3(4.28e-06)]_\ 10 chr4:39529425-39529505 6.17e-01 80 chrX:31881168-31881248 8.19e-01 80 chrX:48433054-48433134 7.26e-03 80 chr19:47288093-47288173 6.75e-03 67_[+1(7.15e-06)]_5 chr16:46917841-46917921 1.78e-03 31_[+3(4.28e-06)]_41 chr16:4321391-4321471 7.25e-01 80 chr16:2059963-2060043 4.34e-01 80 chr12:57848792-57848872 5.39e-04 67_[+1(7.15e-06)]_5 chr9:139743653-139743733 6.14e-01 80 chr10:102747300-10274738 5.66e-02 80 chr7:2144014-2144094 1.49e-02 44_[+1(3.48e-05)]_28 chr1:110162281-110162361 1.59e-01 80 chr15:30918274-30918354 6.29e-02 80 chr2:10260754-10260834 3.58e-01 80 chr3:135915521-135915601 3.69e-03 22_[+3(2.37e-05)]_50 chr3:128399765-128399845 4.74e-01 80 chr7:99933431-99933511 4.04e-01 80 chr13:27825670-27825750 3.67e-02 40_[+5(3.10e-05)]_32 chr1:40364863-40364943 1.69e-02 80 chr6:150284882-150284962 3.20e-01 80 chr17:8113834-8113914 5.97e-01 80 chr19:10989956-10990036 4.52e-02 80 chr6:43739791-43739871 9.90e-01 80 chr19:54694247-54694327 6.04e-02 80 chr12:2922007-2922087 4.58e-02 67_[+4(4.51e-05)]_5 chr14:90849647-90849727 1.73e-01 80 chr1:90288727-90288807 1.57e-05 58_[+3(1.14e-05)]_14 chr5:176739270-176739350 3.84e-01 80 chr22:41682129-41682209 1.94e-01 80 chr4:109571682-109571762 5.72e-01 80 chr17:8152641-8152721 5.37e-03 65_[+1(7.96e-05)]_7 chr19:5773847-5773927 1.40e-03 22_[+1(7.15e-06)]_50 chr6:151187409-151187489 2.08e-01 80 chr20:48808938-48809018 3.38e-02 80 chr3:128968461-128968541 5.77e-01 80 chr16:30418611-30418691 4.49e-01 80 chr3:12526094-12526174 2.33e-01 80 chr1:52522022-52522102 3.62e-01 80 chr5:175815538-175815618 2.13e-01 80 chr12:113622999-11362307 2.48e-01 80 chr4:174255688-174255768 9.88e-01 80 chr7:97501655-97501735 6.02e-01 80 chr11:123612278-12361235 9.92e-01 80 chr14:23398457-23398537 3.72e-01 80 chr4:140222685-140222765 1.21e-02 58_[+4(4.51e-05)]_14 chr19:46242892-46242972 7.40e-03 46_[+2(7.17e-05)]_11_[+4(8.78e-05)]_\ 7 chr16:8159665-8159745 4.16e-06 5_[+5(3.10e-05)]_16_[+2(5.22e-05)]_\ 6_[+4(1.37e-05)]_29 chr6:126102055-126102135 2.97e-01 80 chr11:73490459-73490539 2.77e-01 80 chr12:98910328-98910408 2.68e-02 80 chr9:100745279-100745359 4.62e-01 80 chr17:2239667-2239747 4.75e-01 80 chr9:101984360-101984440 1.26e-03 53_[+4(6.17e-05)]_19 chr19:57791250-57791330 3.26e-04 3_[+2(5.22e-05)]_15_[+1(1.14e-05)]_\ 46 chr19:45927098-45927178 3.25e-02 1_[+4(2.49e-05)]_71 chr19:5903863-5903943 1.89e-01 80 chr3:167814042-167814122 1.37e-01 80 chr7:99933759-99933839 9.83e-01 80 chrX:347759-347839 2.91e-01 80 chr19:1672497-1672577 3.42e-01 80 chr16:75681414-75681494 7.79e-01 80 chr19:40324619-40324699 5.35e-01 80 chr16:11945274-11945354 5.17e-01 80 chr13:53226589-53226669 1.31e-03 [+3(1.65e-05)]_72 chr14:50052932-50053012 3.35e-01 80 chr16:15188015-15188095 2.76e-01 80 chrX:102942086-102942166 6.63e-02 80 chr12:10766113-10766193 1.53e-02 13_[+5(7.22e-06)]_59 chr15:41708952-41709032 5.22e-01 80 chr3:44379724-44379804 1.00e+00 80 chr2:232328620-232328700 3.23e-02 80 chr17:7475870-7475950 9.33e-01 80 chr6:33359565-33359645 9.04e-01 80 chr14:59950851-59950931 8.90e-01 80 chr3:52720066-52720146 8.86e-02 80 chr12:110906413-11090649 9.49e-02 80 chr3:99536551-99536631 9.36e-02 80 chr5:82373115-82373195 6.54e-01 80 chr19:36706083-36706163 6.55e-01 80 chr15:55489051-55489131 4.21e-02 9_[+4(8.78e-05)]_63 chr17:33469253-33469333 8.61e-05 36_[+5(5.49e-05)]_6_[+2(3.26e-05)]_\ [+4(8.78e-05)]_14 chr3:133524680-133524760 6.63e-01 80 chr8:101734810-101734890 8.12e-01 80 chr12:123011338-12301141 1.18e-01 80 chr19:58331078-58331158 5.03e-01 80 chr2:70313913-70313993 1.14e-02 3_[+5(3.10e-05)]_69 chr17:76858316-76858396 5.59e-01 80 chr1:67896313-67896393 1.87e-01 80 chr12:22697391-22697471 6.42e-01 80 chr17:34958050-34958130 9.94e-01 80 chr15:85114252-85114332 9.68e-01 80 chr2:68385029-68385109 1.47e-01 80 chr20:17949341-17949421 3.61e-02 80 chr8:55047783-55047863 9.97e-02 4_[+2(3.26e-05)]_68 chr8:30601754-30601834 3.17e-01 80 chr11:118888970-11888905 6.02e-01 80 chr2:136742938-136743018 2.30e-01 80 chr1:70017535-70017615 8.62e-07 6_[+5(3.10e-05)]_16_[+2(5.22e-05)]_\ 6_[+4(1.37e-05)]_13_[+5(7.22e-06)]_7 chr9:127962932-127963012 7.37e-02 80 chr6:83902863-83902943 6.91e-01 80 chr1:150208706-150208786 5.85e-01 80 chr16:23690045-23690125 9.26e-01 80 chr6:80714454-80714534 6.89e-01 80 chr7:50860136-50860216 1.57e-02 80 chr5:72794348-72794428 3.76e-01 80 chr2:20251666-20251746 3.43e-02 20_[+4(7.41e-05)]_52 chr1:76251718-76251798 1.23e-01 80 chr22:36925070-36925150 5.98e-01 80 chr3:119182427-119182507 1.90e-01 80 chr11:59383604-59383684 1.38e-01 80 chr1:17768030-17768110 3.94e-04 15_[+3(1.14e-05)]_18_[+1(7.15e-06)]_\ 31 chr2:232571868-232571948 1.24e-02 49_[+5(3.10e-05)]_23 chr15:32907675-32907755 3.91e-01 80 chr5:180708426-180708506 1.39e-01 80 chr2:99771526-99771606 8.33e-01 80 chr15:50647577-50647657 3.50e-01 80 chr19:47613247-47613327 1.69e-03 18_[+1(7.15e-06)]_54 chr7:66460350-66460430 2.02e-01 80 chr12:21654705-21654785 3.27e-01 80 chr19:17970866-17970946 1.20e-01 80 chr6:158034157-158034237 9.84e-02 80 chr10:18948137-18948217 1.03e-02 26_[+4(4.51e-05)]_46 chr19:9695112-9695192 3.26e-01 80 chr1:38061415-38061495 3.40e-03 51_[+3(2.37e-05)]_21 chr8:42072547-42072627 4.34e-03 1_[+1(7.15e-06)]_71 chr14:20923382-20923462 3.72e-01 80 chr13:114770379-11477045 6.79e-03 80 chr5:133984293-133984373 9.96e-01 80 chr10:103912406-10391248 1.50e-01 80 chr20:30135144-30135224 1.49e-01 80 chr2:122494344-122494424 5.79e-03 80 chr5:157158475-157158555 5.10e-03 20_[+1(3.48e-05)]_52 chr6:90529437-90529517 6.27e-02 42_[+2(5.22e-05)]_30 chr2:88927414-88927494 3.90e-02 7_[+4(6.17e-05)]_65 chr17:14212447-14212527 3.61e-01 80 chr1:8938184-8938264 6.98e-02 20_[+5(3.54e-05)]_52 chr16:74330791-74330871 8.20e-01 80 chr11:62599411-62599491 6.23e-01 80 chr2:44588761-44588841 7.89e-01 80 chr11:118851064-11885114 1.83e-01 80 chr19:37064027-37064107 1.57e-01 61_[+2(3.26e-05)]_11 chr15:75165527-75165607 6.85e-02 80 chr11:46867815-46867895 9.29e-01 80 chr12:64615952-64616032 7.96e-01 80 chr3:100120098-100120178 1.43e-01 80 chr4:56261792-56261872 8.58e-02 59_[+4(6.17e-05)]_13 chr12:110841376-11084145 1.13e-01 80 chr4:146019448-146019528 7.09e-04 17_[+5(7.22e-06)]_35_[+4(6.17e-05)]_\ 12 chr7:65580031-65580111 8.49e-01 80 chr12:54674650-54674730 1.11e-01 80 chr12:25102010-25102090 9.87e-04 4_[+2(5.22e-05)]_53_[+1(7.15e-06)]_\ 7 chr17:76210332-76210412 8.19e-01 80 chr9:100807817-100807897 8.84e-03 54_[+2(7.17e-05)]_18 chr6:31588561-31588641 7.59e-01 80 chr19:46195050-46195130 6.96e-01 80 chr14:50087129-50087209 1.82e-01 80 chr16:70557800-70557880 9.01e-02 80 chr7:56019582-56019662 5.45e-01 80 chr3:131221702-131221782 2.96e-02 40_[+2(3.26e-05)]_32 chr9:135545256-135545336 8.03e-01 80 chr5:114961751-114961831 2.96e-01 80 chr12:46662595-46662675 4.45e-01 80 chr1:101491499-101491579 2.56e-01 80 chr8:99057602-99057682 9.34e-02 80 chr14:31028416-31028496 5.54e-01 80 chr12:104324088-10432416 3.25e-01 80 chr11:107729337-10772941 2.84e-02 80 chr5:180237336-180237416 1.23e-01 80 chr6:117996493-117996573 4.51e-01 80 chr17:38574167-38574247 6.44e-01 80 chr14:24584105-24584185 9.50e-01 80 chr21:33765238-33765318 1.48e-01 70_[+2(7.17e-05)]_2 chr1:244998682-244998762 8.91e-01 80 chr5:154134496-154134576 4.26e-01 80 chr12:57881815-57881895 2.12e-02 31_[+1(7.15e-06)]_41 chr2:127066179-127066259 6.15e-01 80 chr2:207024721-207024801 5.95e-01 80 chr8:145023953-145024033 9.40e-01 80 chr4:120987866-120987946 2.39e-01 80 chr5:158636781-158636861 1.07e-02 10_[+5(3.10e-05)]_62 chr6:41889197-41889277 6.46e-03 80 chr16:4321637-4321717 3.57e-01 80 chr4:99850059-99850139 3.26e-03 14_[+5(5.49e-05)]_58 chr19:10217034-10217114 3.06e-01 80 chr4:95129045-95129125 4.35e-01 80 chr2:61765471-61765551 4.32e-01 80 chr20:43540081-43540161 2.34e-02 47_[+4(1.37e-05)]_25 chr14:65453699-65453779 1.21e-01 7_[+5(7.66e-05)]_65 chr2:10588927-10589007 2.76e-02 12_[+2(3.26e-05)]_60 chr7:2394248-2394328 4.40e-02 80 chr2:175113571-175113651 8.31e-01 80 chr9:116172771-116172851 3.58e-01 80 chr16:68027448-68027528 2.16e-01 80 chr2:73441429-73441509 2.26e-01 80 chr15:50647371-50647451 1.03e-02 11_[+2(8.34e-05)]_61 chr6:30585383-30585463 2.81e-02 51_[+4(7.41e-05)]_21 chr7:127291874-127291954 9.28e-01 80 chr7:151216955-151217035 3.67e-02 52_[+5(3.10e-05)]_20 chr8:25316539-25316619 9.82e-01 80 chr16:31519700-31519780 8.17e-01 80 chr1:156783708-156783788 9.15e-02 41_[+2(3.26e-05)]_31 chr16:89555637-89555717 1.19e-03 59_[+3(4.28e-06)]_13 chr22:32026611-32026691 7.64e-01 80 chr10:25305778-25305858 8.18e-01 80 chrX:100646009-100646089 4.77e-01 80 chr6:111303246-111303326 6.85e-02 80 chr19:58898223-58898303 5.76e-01 80 chr3:150264715-150264795 1.02e-02 65_[+4(6.17e-05)]_7 chr2:75062127-75062207 1.76e-01 80 chr12:93861410-93861490 1.49e-01 80 chr16:4475460-4475540 2.01e-01 80 chr5:138940547-138940627 8.32e-01 80 chr17:79895334-79895414 9.07e-02 67_[+2(5.22e-05)]_5 chr1:161147430-161147510 8.42e-01 80 chr17:61904870-61904950 9.57e-01 80 chr12:124068946-12406902 6.88e-01 80 chr17:79259296-79259376 2.80e-02 35_[+5(3.10e-05)]_37 chr11:14541791-14541871 9.12e-01 80 chr5:162887035-162887115 9.37e-01 80 chr15:66874526-66874606 8.18e-04 31_[+3(1.65e-05)]_41 chr4:40240505-40240585 2.12e-02 80 chr2:74426224-74426304 4.27e-01 80 chr15:91537734-91537814 8.24e-01 80 chr12:58165778-58165858 8.22e-01 80 chr10:30841247-30841327 1.47e-03 80 chr19:40476712-40476792 5.29e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n08.farnam.hpc.yale.internal ********************************************************************************