******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/CSDE1.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chrX:1949560-1949640 1.0000 80 chrX:1567439-1567519 1.0000 80 chr22:20829858-20829938 1.0000 80 chr20:61966632-61966712 1.0000 80 chr6:161468638-161468718 1.0000 80 chr1:39250506-39250586 1.0000 80 chr7:134270844-134270924 1.0000 80 chrX:1566482-1566562 1.0000 80 chr4:155113932-155114012 1.0000 80 chr1:160176353-160176433 1.0000 80 chr21:21420591-21420671 1.0000 80 chr7:150658626-150658706 1.0000 80 chr1:245836494-245836574 1.0000 80 chr11:9575772-9575852 1.0000 80 chr6:164006567-164006647 1.0000 80 chr22:21944570-21944650 1.0000 80 chr1:246316042-246316122 1.0000 80 chr22:17087107-17087187 1.0000 80 chr1:12496805-12496885 1.0000 80 chr6:29936014-29936094 1.0000 80 chr7:106647292-106647372 1.0000 80 chr6:154827396-154827476 1.0000 80 chr7:20347817-20347897 1.0000 80 chr3:44482610-44482690 1.0000 80 chr16:89087191-89087271 1.0000 80 chr6:27636845-27636925 1.0000 80 chr20:36034596-36034676 1.0000 80 chr3:32823584-32823664 1.0000 80 chr1:26612687-26612767 1.0000 80 chr6:43132530-43132610 1.0000 80 chr11:62477132-62477212 1.0000 80 chr6:138184952-138185032 1.0000 80 chrX:47225757-47225837 1.0000 80 chr20:49050008-49050088 1.0000 80 chr18:9918448-9918528 1.0000 80 chr18:3665319-3665399 1.0000 80 chr22:22254880-22254960 1.0000 80 chr15:96104812-96104892 1.0000 80 chr5:139135120-139135200 1.0000 80 chrX:2243319-2243399 1.0000 80 chr6:28458455-28458535 1.0000 80 chr6:89130734-89130814 1.0000 80 chr1:220081383-220081463 1.0000 80 chr7:148786932-148787012 1.0000 80 chr6:7030258-7030338 1.0000 80 chr1:161190657-161190737 1.0000 80 chr8:105630570-105630650 1.0000 80 chr19:14496165-14496245 1.0000 80 chr7:106706708-106706788 1.0000 80 chr22:20060024-20060104 1.0000 80 chr5:64778116-64778196 1.0000 80 chr6:3163963-3164043 1.0000 80 chr17:73422891-73422971 1.0000 80 chr11:5146377-5146457 1.0000 80 chr15:35265301-35265381 1.0000 80 chr18:73424439-73424519 1.0000 80 chr10:74263631-74263711 1.0000 80 chr22:22044932-22045012 1.0000 80 chr1:27889685-27889765 1.0000 80 chr8:66776788-66776868 1.0000 80 chr9:130921000-130921080 1.0000 80 chr22:19768532-19768612 1.0000 80 chr18:9886117-9886197 1.0000 80 chr3:33493664-33493744 1.0000 80 chr5:148929112-148929192 1.0000 80 chrX:153236458-153236538 1.0000 80 chr12:56617662-56617742 1.0000 80 chr2:174602592-174602672 1.0000 80 chr18:20545026-20545106 1.0000 80 chr9:115818972-115819052 1.0000 80 chr15:20514680-20514760 1.0000 80 chr22:19408590-19408670 1.0000 80 chr3:13492850-13492930 1.0000 80 chr10:17472657-17472737 1.0000 80 chr7:120622223-120622303 1.0000 80 chr10:50399641-50399721 1.0000 80 chr22:21290549-21290629 1.0000 80 chr19:47819309-47819389 1.0000 80 chr1:91968237-91968317 1.0000 80 chr17:63169158-63169238 1.0000 80 chr16:186279-186359 1.0000 80 chr10:29101643-29101723 1.0000 80 chr17:4270064-4270144 1.0000 80 chr19:3812907-3812987 1.0000 80 chr6:26283783-26283863 1.0000 80 chr7:35042791-35042871 1.0000 80 chr12:92075984-92076064 1.0000 80 chr22:19802552-19802632 1.0000 80 chr6:119579981-119580061 1.0000 80 chr1:145066981-145067061 1.0000 80 chr1:21348212-21348292 1.0000 80 chr10:73655993-73656073 1.0000 80 chr1:3815704-3815784 1.0000 80 chr21:39448093-39448173 1.0000 80 chr6:143984608-143984688 1.0000 80 chr6:157738710-157738790 1.0000 80 chr22:22408514-22408594 1.0000 80 chr7:72015657-72015737 1.0000 80 chr7:106649205-106649285 1.0000 80 chr7:116568141-116568221 1.0000 80 chr14:74319005-74319085 1.0000 80 chr7:150791929-150792009 1.0000 80 chr2:24877708-24877788 1.0000 80 chr1:108623429-108623509 1.0000 80 chr21:46938631-46938711 1.0000 80 chr19:52511473-52511553 1.0000 80 chr1:247093401-247093481 1.0000 80 chr2:145273040-145273120 1.0000 80 chr3:119187708-119187788 1.0000 80 chr3:37270897-37270977 1.0000 80 chr1:43310616-43310696 1.0000 80 chr20:35374635-35374715 1.0000 80 chr18:3012177-3012257 1.0000 80 chr1:46993155-46993235 1.0000 80 chr22:19915773-19915853 1.0000 80 chr5:39016447-39016527 1.0000 80 chr5:140099310-140099390 1.0000 80 chr10:99639226-99639306 1.0000 80 chr1:24745432-24745512 1.0000 80 chr12:54717522-54717602 1.0000 80 chr5:81581689-81581769 1.0000 80 chr7:121051202-121051282 1.0000 80 chr2:158120628-158120708 1.0000 80 chr1:181075216-181075296 1.0000 80 chr1:193091947-193092027 1.0000 80 chr6:37464569-37464649 1.0000 80 chr10:102288481-10228856 1.0000 80 chr21:38710792-38710872 1.0000 80 chrX:1021127-1021207 1.0000 80 chr1:26704421-26704501 1.0000 80 chr8:38007929-38008009 1.0000 80 chr19:2362702-2362782 1.0000 80 chrX:950807-950887 1.0000 80 chr22:19080366-19080446 1.0000 80 chr22:19759725-19759805 1.0000 80 chr7:137685798-137685878 1.0000 80 chr11:77849526-77849606 1.0000 80 chr19:7805633-7805713 1.0000 80 chr10:75575523-75575603 1.0000 80 chr7:106684567-106684647 1.0000 80 chr10:52142351-52142431 1.0000 80 chr7:120682490-120682570 1.0000 80 chr7:100108893-100108973 1.0000 80 chr7:100401571-100401651 1.0000 80 chr19:52430417-52430497 1.0000 80 chr1:9354196-9354276 1.0000 80 chrX:503103-503183 1.0000 80 chr2:170441583-170441663 1.0000 80 chr20:10415771-10415851 1.0000 80 chr12:122492751-12249283 1.0000 80 chr12:96253392-96253472 1.0000 80 chr6:30690729-30690809 1.0000 80 chr11:33060941-33061021 1.0000 80 chr12:28275352-28275432 1.0000 80 chr17:36907553-36907633 1.0000 80 chr5:36881248-36881328 1.0000 80 chrX:153237051-153237131 1.0000 80 chr6:27199645-27199725 1.0000 80 chr6:50881318-50881398 1.0000 80 chr6:37321350-37321430 1.0000 80 chr6:10886463-10886543 1.0000 80 chr19:37663718-37663798 1.0000 80 chr19:50321368-50321448 1.0000 80 chr7:1619590-1619670 1.0000 80 chr7:1463242-1463322 1.0000 80 chr2:26296732-26296812 1.0000 80 chr2:152265860-152265940 1.0000 80 chr19:59085368-59085448 1.0000 80 chr9:131873674-131873754 1.0000 80 chr22:18359870-18359950 1.0000 80 chr7:155407892-155407972 1.0000 80 chr13:93886919-93886999 1.0000 80 chrX:47342095-47342175 1.0000 80 chr22:20069401-20069481 1.0000 80 chr6:37073512-37073592 1.0000 80 chr2:43446535-43446615 1.0000 80 chr20:5730940-5731020 1.0000 80 chr20:48428170-48428250 1.0000 80 chr12:92733153-92733233 1.0000 80 chr19:46368235-46368315 1.0000 80 chr5:81573322-81573402 1.0000 80 chr15:65809172-65809252 1.0000 80 chr7:95987788-95987868 1.0000 80 chr7:72195532-72195612 1.0000 80 chr17:79895826-79895906 1.0000 80 chr11:10879321-10879401 1.0000 80 chr19:52408295-52408375 1.0000 80 chr11:88071471-88071551 1.0000 80 chr7:98822663-98822743 1.0000 80 chr22:19815033-19815113 1.0000 80 chr3:177061953-177062033 1.0000 80 chr6:30538686-30538766 1.0000 80 chr7:102631921-102632001 1.0000 80 chr10:73611591-73611671 1.0000 80 chr1:65681077-65681157 1.0000 80 chr1:47695699-47695779 1.0000 80 chr3:183602224-183602304 1.0000 80 chr7:100248023-100248103 1.0000 80 chr2:26986761-26986841 1.0000 80 chr1:21469655-21469735 1.0000 80 chr1:142832091-142832171 1.0000 80 chr22:20068227-20068307 1.0000 80 chr6:27560949-27561029 1.0000 80 chr7:139316170-139316250 1.0000 80 chr6:157313552-157313632 1.0000 80 chr11:47401747-47401827 1.0000 80 chr6:134495607-134495687 1.0000 80 chrX:73071091-73071171 1.0000 80 chr1:28367112-28367192 1.0000 80 chr15:96390373-96390453 1.0000 80 chr6:161451404-161451484 1.0000 80 chr12:94132542-94132622 1.0000 80 chr6:26170113-26170193 1.0000 80 chr6:27129524-27129604 1.0000 80 chr16:19566852-19566932 1.0000 80 chr1:200976646-200976726 1.0000 80 chr15:79165887-79165967 1.0000 80 chr22:19450537-19450617 1.0000 80 chr19:49127311-49127391 1.0000 80 chr1:149860487-149860567 1.0000 80 chr1:117601892-117601972 1.0000 80 chr22:22510976-22511056 1.0000 80 chr12:110517893-11051797 1.0000 80 chr16:81611655-81611735 1.0000 80 chr6:154819646-154819726 1.0000 80 chr6:147480840-147480920 1.0000 80 chr2:26633641-26633721 1.0000 80 chr20:61603564-61603644 1.0000 80 chr1:46269889-46269969 1.0000 80 chr19:52490178-52490258 1.0000 80 chr22:20072872-20072952 1.0000 80 chr19:50316865-50316945 1.0000 80 chr3:57741774-57741854 1.0000 80 chr7:151202155-151202235 1.0000 80 chr21:45394986-45395066 1.0000 80 chr15:40675034-40675114 1.0000 80 chr1:38990079-38990159 1.0000 80 chr12:30848858-30848938 1.0000 80 chr7:66461005-66461085 1.0000 80 chr1:202311566-202311646 1.0000 80 chr1:145076193-145076273 1.0000 80 chr6:33396703-33396783 1.0000 80 chr4:6719259-6719339 1.0000 80 chr10:49572061-49572141 1.0000 80 chr6:28220469-28220549 1.0000 80 chr22:32367126-32367206 1.0000 80 chr2:242576875-242576955 1.0000 80 chr14:23480434-23480514 1.0000 80 chr12:122063779-12206385 1.0000 80 chr22:19284946-19285026 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_CSDE1/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/CSDE1.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.275 C 0.228 G 0.234 T 0.263 Background letter frequencies (from file dataset with add-one prior applied): A 0.275 C 0.228 G 0.234 T 0.263 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF GCCATCTT MEME-1 width = 8 sites = 39 llr = 335 E-value = 3.7e-010 ******************************************************************************** -------------------------------------------------------------------------------- Motif GCCATCTT MEME-1 Description -------------------------------------------------------------------------------- Simplified A 2:19::1: pos.-specific C :a91:7:: probability G 8:1::2:: matrix T 1:::a19a bits 2.1 * 1.9 * * 1.7 * * * 1.5 **** ** Relative 1.3 **** ** Entropy 1.1 ******** (12.4 bits) 0.9 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GCCATCTT consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATCTT MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:52408295-52408375 57 1.39e-05 TCTGGGCGCG GCCATCTT GGTAGATCTG chr11:10879321-10879401 13 1.39e-05 GCCCGCGACC GCCATCTT AGGCAGTTCC chrX:47342095-47342175 14 1.39e-05 TACGGGAGCC GCCATCTT GGAAGGGCGG chr20:10415771-10415851 60 1.39e-05 GTGTTTCGCT GCCATCTT AAATCCTGGC chrX:1021127-1021207 9 1.39e-05 ggccggct gccatctt gggagtggcc chr20:35374635-35374715 19 1.39e-05 GGCCGGCGGC GCCATCTT TGATGTAGTT chr3:119187708-119187788 45 1.39e-05 GGCCACGGTG GCCATCTT TGTGCGGGGC chr19:52511473-52511553 61 1.39e-05 CATGGGGGCC GCCATCTT TGAGTATCTG chr7:72015657-72015737 69 1.39e-05 agctgtggtg gccatctt gaga chr1:245836494-245836574 70 1.39e-05 GCTGGGCGCT GCCATCTT AGG chr4:155113932-155114012 68 1.39e-05 gtggcccacc gccatctt gggag chrX:1566482-1566562 24 1.39e-05 GACACACACC GCCATCTT GGATAAGCAC chr7:134270844-134270924 26 1.39e-05 aaggcttgct gccatctt gagagtggct chrX:1567439-1567519 54 1.39e-05 GACACACACG GCCATCTT GGATAAGCAC chr19:52490178-52490258 50 2.81e-05 CCTGACGGCA GCCATGTT TGAAAATTGG chr11:33060941-33061021 19 2.81e-05 GCGGTCATCG GCCATGTT TTCCACCTCT chr1:149860487-149860567 1 5.59e-05 . GCCCTCTT TTCCTGAAAT chr11:62477132-62477212 51 5.59e-05 GGTCCCTTCC GCCCTCTT CTGGTCTCAA chr7:20347817-20347897 17 5.59e-05 CTGTTCTTCA GCCCTCTT TGTGCTTTTC chr15:79165887-79165967 69 7.04e-05 AGATGGCGGC GCCATCAT GGCC chr5:36881248-36881328 51 7.04e-05 GTCTCTTAAG GCCATCAT TGTAATTTTA chr7:148786932-148787012 23 7.04e-05 acaggcgccc gccatcat gccaggctaa chr19:37663718-37663798 73 8.64e-05 CGCGTGGGCC GCCATTTT chr17:4270064-4270144 9 8.64e-05 CGTCCGCC GCCATTTT GGGAAGGTCG chr5:148929112-148929192 47 8.64e-05 ACGTCGTTCC GCCATTTT CTAAGCGGAG chrX:950807-950887 46 1.02e-04 agatggcggc tccatctt cccggcagga chrX:2243319-2243399 44 1.02e-04 agatggcggc tccatctt cccggcagga chr17:73422891-73422971 27 1.16e-04 gtgcagtggc gcgatctt ggctcaccgt chr22:17087107-17087187 39 1.16e-04 gtgcagtggt gcgatctt ggctcgctgc chr6:134495607-134495687 66 1.33e-04 GGAGTTATTG GCAATCTT CTGAATA chr19:47819309-47819389 15 1.33e-04 gggcagtggc gcaatctt gactcactgc chr19:52430417-52430497 23 1.50e-04 ACGTAGCCAT ACCATGTT TGTCTTGGCT chr7:106649205-106649285 54 1.50e-04 attgggtttc accatgtt ggtcaggctg chr1:21348212-21348292 34 1.50e-04 acaggatttc accatgtt gggcaggctg chr9:130921000-130921080 20 1.50e-04 acgggttttc accatgtt ggtcaggctg chr22:20060024-20060104 16 1.50e-04 acggagtttc accatgtt ggccaggatg chr22:19768532-19768612 70 1.62e-04 actgcacccg gccctgtt ttg chr8:66776788-66776868 48 1.88e-04 aacccatcct gccacctt acgcccctat chr6:119579981-119580061 4 2.19e-04 ATC ACCATCAT ATGCATacag -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATCTT MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:52408295-52408375 1.4e-05 56_[+1]_16 chr11:10879321-10879401 1.4e-05 12_[+1]_60 chrX:47342095-47342175 1.4e-05 13_[+1]_59 chr20:10415771-10415851 1.4e-05 59_[+1]_13 chrX:1021127-1021207 1.4e-05 8_[+1]_64 chr20:35374635-35374715 1.4e-05 18_[+1]_54 chr3:119187708-119187788 1.4e-05 44_[+1]_28 chr19:52511473-52511553 1.4e-05 60_[+1]_12 chr7:72015657-72015737 1.4e-05 68_[+1]_4 chr1:245836494-245836574 1.4e-05 69_[+1]_3 chr4:155113932-155114012 1.4e-05 67_[+1]_5 chrX:1566482-1566562 1.4e-05 23_[+1]_49 chr7:134270844-134270924 1.4e-05 25_[+1]_47 chrX:1567439-1567519 1.4e-05 53_[+1]_19 chr19:52490178-52490258 2.8e-05 49_[+1]_23 chr11:33060941-33061021 2.8e-05 18_[+1]_54 chr1:149860487-149860567 5.6e-05 [+1]_72 chr11:62477132-62477212 5.6e-05 50_[+1]_22 chr7:20347817-20347897 5.6e-05 16_[+1]_56 chr15:79165887-79165967 7e-05 68_[+1]_4 chr5:36881248-36881328 7e-05 50_[+1]_22 chr7:148786932-148787012 7e-05 22_[+1]_50 chr19:37663718-37663798 8.6e-05 72_[+1] chr17:4270064-4270144 8.6e-05 8_[+1]_64 chr5:148929112-148929192 8.6e-05 46_[+1]_26 chrX:950807-950887 0.0001 45_[+1]_27 chrX:2243319-2243399 0.0001 43_[+1]_29 chr17:73422891-73422971 0.00012 26_[+1]_46 chr22:17087107-17087187 0.00012 38_[+1]_34 chr6:134495607-134495687 0.00013 65_[+1]_7 chr19:47819309-47819389 0.00013 14_[+1]_58 chr19:52430417-52430497 0.00015 22_[+1]_50 chr7:106649205-106649285 0.00015 53_[+1]_19 chr1:21348212-21348292 0.00015 33_[+1]_39 chr9:130921000-130921080 0.00015 19_[+1]_53 chr22:20060024-20060104 0.00015 15_[+1]_57 chr22:19768532-19768612 0.00016 69_[+1]_3 chr8:66776788-66776868 0.00019 47_[+1]_25 chr6:119579981-119580061 0.00022 3_[+1]_69 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATCTT MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GCCATCTT width=8 seqs=39 chr19:52408295-52408375 ( 57) GCCATCTT 1 chr11:10879321-10879401 ( 13) GCCATCTT 1 chrX:47342095-47342175 ( 14) GCCATCTT 1 chr20:10415771-10415851 ( 60) GCCATCTT 1 chrX:1021127-1021207 ( 9) GCCATCTT 1 chr20:35374635-35374715 ( 19) GCCATCTT 1 chr3:119187708-119187788 ( 45) GCCATCTT 1 chr19:52511473-52511553 ( 61) GCCATCTT 1 chr7:72015657-72015737 ( 69) GCCATCTT 1 chr1:245836494-245836574 ( 70) GCCATCTT 1 chr4:155113932-155114012 ( 68) GCCATCTT 1 chrX:1566482-1566562 ( 24) GCCATCTT 1 chr7:134270844-134270924 ( 26) GCCATCTT 1 chrX:1567439-1567519 ( 54) GCCATCTT 1 chr19:52490178-52490258 ( 50) GCCATGTT 1 chr11:33060941-33061021 ( 19) GCCATGTT 1 chr1:149860487-149860567 ( 1) GCCCTCTT 1 chr11:62477132-62477212 ( 51) GCCCTCTT 1 chr7:20347817-20347897 ( 17) GCCCTCTT 1 chr15:79165887-79165967 ( 69) GCCATCAT 1 chr5:36881248-36881328 ( 51) GCCATCAT 1 chr7:148786932-148787012 ( 23) GCCATCAT 1 chr19:37663718-37663798 ( 73) GCCATTTT 1 chr17:4270064-4270144 ( 9) GCCATTTT 1 chr5:148929112-148929192 ( 47) GCCATTTT 1 chrX:950807-950887 ( 46) TCCATCTT 1 chrX:2243319-2243399 ( 44) TCCATCTT 1 chr17:73422891-73422971 ( 27) GCGATCTT 1 chr22:17087107-17087187 ( 39) GCGATCTT 1 chr6:134495607-134495687 ( 66) GCAATCTT 1 chr19:47819309-47819389 ( 15) GCAATCTT 1 chr19:52430417-52430497 ( 23) ACCATGTT 1 chr7:106649205-106649285 ( 54) ACCATGTT 1 chr1:21348212-21348292 ( 34) ACCATGTT 1 chr9:130921000-130921080 ( 20) ACCATGTT 1 chr22:20060024-20060104 ( 16) ACCATGTT 1 chr22:19768532-19768612 ( 70) GCCCTGTT 1 chr8:66776788-66776868 ( 48) GCCACCTT 1 chr6:119579981-119580061 ( 4) ACCATCAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATCTT MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.78941 E= 3.7e-010 -84 -1193 177 -236 -1193 213 -1193 -1193 -242 198 -219 -1193 171 -115 -1193 -1193 -1193 -315 -1193 189 -1193 165 -19 -177 -142 -1193 -1193 177 -1193 -1193 -1193 193 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATCTT MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 39 E= 3.7e-010 0.153846 0.000000 0.794872 0.051282 0.000000 1.000000 0.000000 0.000000 0.051282 0.897436 0.051282 0.000000 0.897436 0.102564 0.000000 0.000000 0.000000 0.025641 0.000000 0.974359 0.000000 0.717949 0.205128 0.076923 0.102564 0.000000 0.000000 0.897436 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCATCTT MEME-1 regular expression -------------------------------------------------------------------------------- GCCAT[CG]TT -------------------------------------------------------------------------------- Time 5.07 secs. ******************************************************************************** ******************************************************************************** MOTIF CCTKCCTC MEME-2 width = 8 sites = 21 llr = 206 E-value = 7.4e-007 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCTKCCTC MEME-2 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C aa1:9a:a probability G :::6:::: matrix T ::941:a: bits 2.1 ** * * 1.9 ** *** 1.7 ** *** 1.5 ** **** Relative 1.3 *** **** Entropy 1.1 *** **** (14.2 bits) 0.9 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CCTGCCTC consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTKCCTC MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:152265860-152265940 10 9.97e-06 agcgattct cctgcctc agcttcccaa chr22:19759725-19759805 10 9.97e-06 agcgattct cctgcctc agcctcccaa chr14:74319005-74319085 69 9.97e-06 aagcgattct cctgcctc agcc chr19:47819309-47819389 63 9.97e-06 aagcgattct cctgcctc agcctcccaa chr1:12496805-12496885 29 9.97e-06 aagcaattct cctgcctc tgcctcccga chr22:21944570-21944650 26 9.97e-06 gagcgattct cctgcctc agcctcccga chr6:164006567-164006647 65 9.97e-06 aagcaattct cctgcctc agaccccc chr7:150658626-150658706 6 9.97e-06 atctg cctgcctc ggcctcccaa chr15:96390373-96390453 58 2.12e-05 ttctttcttt ccttcctc ccttgttttt chr6:30538686-30538766 47 2.12e-05 TCTCTCTTCC CCTTCCTC TCGTGTCTTC chr7:98822663-98822743 17 2.12e-05 ttccttcctt ccttcctc tttctttcct chr6:10886463-10886543 27 2.12e-05 AAAAAATTCC CCTTCCTC CCCACCACGG chr7:150791929-150792009 48 2.12e-05 ttccttcctt ccttcctc agaatattgg chr22:22044932-22045012 35 2.12e-05 TGCTTTTCCT CCTTCCTC ACTTTAATCC chr1:65681077-65681157 22 2.98e-05 aggtcattca cccgcctc ggcctcccaa chr22:19768532-19768612 17 2.98e-05 tcgtgatcca cccgcctc agcctcccaa chr9:130921000-130921080 65 2.98e-05 tcgtgatctg cccgcctc ggcctccc chr7:100108893-100108973 20 4.13e-05 atggagaaac cctgtctc tactaaaaat chr19:49127311-49127391 7 7.37e-05 AGACCT CCTCCCTC ACGCCCCTTT chr17:36907553-36907633 28 7.37e-05 CAATGTTCTC CCTTTCTC ACCTTTGTTT chr1:246316042-246316122 59 7.37e-05 CCAGatttaa cctttctc agccacatct -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTKCCTC MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:152265860-152265940 1e-05 9_[+2]_63 chr22:19759725-19759805 1e-05 9_[+2]_63 chr14:74319005-74319085 1e-05 68_[+2]_4 chr19:47819309-47819389 1e-05 62_[+2]_10 chr1:12496805-12496885 1e-05 28_[+2]_44 chr22:21944570-21944650 1e-05 25_[+2]_47 chr6:164006567-164006647 1e-05 64_[+2]_8 chr7:150658626-150658706 1e-05 5_[+2]_67 chr15:96390373-96390453 2.1e-05 57_[+2]_15 chr6:30538686-30538766 2.1e-05 46_[+2]_26 chr7:98822663-98822743 2.1e-05 16_[+2]_56 chr6:10886463-10886543 2.1e-05 26_[+2]_46 chr7:150791929-150792009 2.1e-05 47_[+2]_25 chr22:22044932-22045012 2.1e-05 34_[+2]_38 chr1:65681077-65681157 3e-05 21_[+2]_51 chr22:19768532-19768612 3e-05 16_[+2]_56 chr9:130921000-130921080 3e-05 64_[+2]_8 chr7:100108893-100108973 4.1e-05 19_[+2]_53 chr19:49127311-49127391 7.4e-05 6_[+2]_66 chr17:36907553-36907633 7.4e-05 27_[+2]_45 chr1:246316042-246316122 7.4e-05 58_[+2]_14 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTKCCTC MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCTKCCTC width=8 seqs=21 chr2:152265860-152265940 ( 10) CCTGCCTC 1 chr22:19759725-19759805 ( 10) CCTGCCTC 1 chr14:74319005-74319085 ( 69) CCTGCCTC 1 chr19:47819309-47819389 ( 63) CCTGCCTC 1 chr1:12496805-12496885 ( 29) CCTGCCTC 1 chr22:21944570-21944650 ( 26) CCTGCCTC 1 chr6:164006567-164006647 ( 65) CCTGCCTC 1 chr7:150658626-150658706 ( 6) CCTGCCTC 1 chr15:96390373-96390453 ( 58) CCTTCCTC 1 chr6:30538686-30538766 ( 47) CCTTCCTC 1 chr7:98822663-98822743 ( 17) CCTTCCTC 1 chr6:10886463-10886543 ( 27) CCTTCCTC 1 chr7:150791929-150792009 ( 48) CCTTCCTC 1 chr22:22044932-22045012 ( 35) CCTTCCTC 1 chr1:65681077-65681157 ( 22) CCCGCCTC 1 chr22:19768532-19768612 ( 17) CCCGCCTC 1 chr9:130921000-130921080 ( 65) CCCGCCTC 1 chr7:100108893-100108973 ( 20) CCTGTCTC 1 chr19:49127311-49127391 ( 7) CCTCCCTC 1 chr17:36907553-36907633 ( 28) CCTTTCTC 1 chr1:246316042-246316122 ( 59) CCTTTCTC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTKCCTC MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.6191 E= 7.4e-007 -1104 213 -1104 -1104 -1104 213 -1104 -1104 -1104 -68 -1104 170 -1104 -226 129 53 -1104 191 -1104 -88 -1104 213 -1104 -1104 -1104 -1104 -1104 193 -1104 213 -1104 -1104 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTKCCTC MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 21 E= 7.4e-007 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.142857 0.000000 0.857143 0.000000 0.047619 0.571429 0.380952 0.000000 0.857143 0.000000 0.142857 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTKCCTC MEME-2 regular expression -------------------------------------------------------------------------------- CCT[GT]CCTC -------------------------------------------------------------------------------- Time 8.90 secs. ******************************************************************************** ******************************************************************************** MOTIF GCCTCCCA MEME-3 width = 8 sites = 24 llr = 225 E-value = 2.9e-006 ******************************************************************************** -------------------------------------------------------------------------------- Motif GCCTCCCA MEME-3 Description -------------------------------------------------------------------------------- Simplified A 1::::::8 pos.-specific C :99:aaa: probability G 91:2:::3 matrix T ::18:::: bits 2.1 ** 1.9 *** 1.7 ** *** 1.5 *** *** Relative 1.3 ******* Entropy 1.1 ******** (13.5 bits) 0.9 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GCCTCCCA consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCTCCCA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr14:23480434-23480514 50 1.04e-05 tcccgccttg gcctccca aagtgctggg chr1:65681077-65681157 31 1.04e-05 acccgcctcg gcctccca aagtgctggg chr22:19759725-19759805 19 1.04e-05 tcctgcctca gcctccca agtaaccggg chr19:47819309-47819389 72 1.04e-05 tcctgcctca gcctccca a chr22:19768532-19768612 26 1.04e-05 acccgcctca gcctccca aagtgctggg chr22:20060024-20060104 70 1.04e-05 gcccacgttg gcctccca aag chr3:44482610-44482690 48 1.04e-05 gcccgccttg gcctccca aagtgctggg chr1:12496805-12496885 6 1.04e-05 cctcc gcctccca gattcaagca chr22:17087107-17087187 64 1.04e-05 tgcaagttcc gcctccca ggttcaagc chr7:150658626-150658706 15 1.04e-05 gcctgcctcg gcctccca aagtgcaagg chr12:30848858-30848938 33 1.93e-05 TGCTATGACC GCCTCCCG TCGGCGGCCG chr22:21944570-21944650 3 1.93e-05 ct gcctcccg ggttcgagcg chr11:33060941-33061021 54 2.86e-05 GAAACACGGC GCCGCCCA GCTGCGAGTC chr3:119187708-119187788 68 2.86e-05 GGGGCGACCC GCCGCCCA CGTGC chr6:28220469-28220549 72 4.08e-05 TGTAGCCCTC ACCTCCCA C chr16:89087191-89087271 6 4.08e-05 caggc acctccca ccaagcctgg chr2:242576875-242576955 51 5.94e-05 ACGACCCCAT GCCGCCCG CAGGGCGCCC chrX:153236458-153236538 43 5.94e-05 CTCCGCAAGA GCCGCCCG AAACTGTCGA chrX:47225757-47225837 47 5.94e-05 CTAAGATGGC GGCTCCCA AGAGACACGA chr6:27560949-27561029 51 7.15e-05 ttgcttgctt gcttCCCA CGCCTTCCAT chr2:152265860-152265940 19 7.15e-05 tcctgcctca gcttccca agtggctggg chr6:164006567-164006647 42 8.19e-05 tgcaacctcc acctcccg aattcaagca chrX:73071091-73071171 22 9.26e-05 ATATGACAAC GCCTGCCA TATTGTCCCT chr15:40675034-40675114 8 1.02e-04 GTATGGC GGCTCCCG AAGCCCCGCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCTCCCA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr14:23480434-23480514 1e-05 49_[+3]_23 chr1:65681077-65681157 1e-05 30_[+3]_42 chr22:19759725-19759805 1e-05 18_[+3]_54 chr19:47819309-47819389 1e-05 71_[+3]_1 chr22:19768532-19768612 1e-05 25_[+3]_47 chr22:20060024-20060104 1e-05 69_[+3]_3 chr3:44482610-44482690 1e-05 47_[+3]_25 chr1:12496805-12496885 1e-05 5_[+3]_67 chr22:17087107-17087187 1e-05 63_[+3]_9 chr7:150658626-150658706 1e-05 14_[+3]_58 chr12:30848858-30848938 1.9e-05 32_[+3]_40 chr22:21944570-21944650 1.9e-05 2_[+3]_70 chr11:33060941-33061021 2.9e-05 53_[+3]_19 chr3:119187708-119187788 2.9e-05 67_[+3]_5 chr6:28220469-28220549 4.1e-05 71_[+3]_1 chr16:89087191-89087271 4.1e-05 5_[+3]_67 chr2:242576875-242576955 5.9e-05 50_[+3]_22 chrX:153236458-153236538 5.9e-05 42_[+3]_30 chrX:47225757-47225837 5.9e-05 46_[+3]_26 chr6:27560949-27561029 7.1e-05 50_[+3]_22 chr2:152265860-152265940 7.1e-05 18_[+3]_54 chr6:164006567-164006647 8.2e-05 41_[+3]_31 chrX:73071091-73071171 9.3e-05 21_[+3]_51 chr15:40675034-40675114 0.0001 7_[+3]_65 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCTCCCA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GCCTCCCA width=8 seqs=24 chr14:23480434-23480514 ( 50) GCCTCCCA 1 chr1:65681077-65681157 ( 31) GCCTCCCA 1 chr22:19759725-19759805 ( 19) GCCTCCCA 1 chr19:47819309-47819389 ( 72) GCCTCCCA 1 chr22:19768532-19768612 ( 26) GCCTCCCA 1 chr22:20060024-20060104 ( 70) GCCTCCCA 1 chr3:44482610-44482690 ( 48) GCCTCCCA 1 chr1:12496805-12496885 ( 6) GCCTCCCA 1 chr22:17087107-17087187 ( 64) GCCTCCCA 1 chr7:150658626-150658706 ( 15) GCCTCCCA 1 chr12:30848858-30848938 ( 33) GCCTCCCG 1 chr22:21944570-21944650 ( 3) GCCTCCCG 1 chr11:33060941-33061021 ( 54) GCCGCCCA 1 chr3:119187708-119187788 ( 68) GCCGCCCA 1 chr6:28220469-28220549 ( 72) ACCTCCCA 1 chr16:89087191-89087271 ( 6) ACCTCCCA 1 chr2:242576875-242576955 ( 51) GCCGCCCG 1 chrX:153236458-153236538 ( 43) GCCGCCCG 1 chrX:47225757-47225837 ( 47) GGCTCCCA 1 chr6:27560949-27561029 ( 51) GCTTCCCA 1 chr2:152265860-152265940 ( 19) GCTTCCCA 1 chr6:164006567-164006647 ( 42) ACCTCCCG 1 chrX:73071091-73071171 ( 22) GCCTGCCA 1 chr15:40675034-40675114 ( 8) GGCTCCCG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCTCCCA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.6693 E= 2.9e-006 -114 -1123 191 -1123 -1123 201 -149 -1123 -1123 201 -1123 -166 -1123 -1123 -49 166 -1123 207 -248 -1123 -1123 213 -1123 -1123 -1123 213 -1123 -1123 145 -1123 10 -1123 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCTCCCA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 24 E= 2.9e-006 0.125000 0.000000 0.875000 0.000000 0.000000 0.916667 0.083333 0.000000 0.000000 0.916667 0.000000 0.083333 0.000000 0.000000 0.166667 0.833333 0.000000 0.958333 0.041667 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.750000 0.000000 0.250000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCTCCCA MEME-3 regular expression -------------------------------------------------------------------------------- GCCTCCC[AG] -------------------------------------------------------------------------------- Time 12.74 secs. ******************************************************************************** ******************************************************************************** MOTIF CARGMTGG MEME-4 width = 8 sites = 41 llr = 345 E-value = 7.1e-009 ******************************************************************************** -------------------------------------------------------------------------------- Motif CARGMTGG MEME-4 Description -------------------------------------------------------------------------------- Simplified A 2a516::: pos.-specific C 8::24::: probability G ::56::aa matrix T :::::a:: bits 2.1 ** 1.9 * *** 1.7 * *** 1.5 * *** Relative 1.3 ** *** Entropy 1.1 *** **** (12.1 bits) 0.9 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CAGGATGG consensus ACC sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CARGMTGG MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr14:23480434-23480514 5 2.49e-05 tggc caggctgg ttttgagctc chr7:66461005-66461085 56 2.49e-05 ctctgtcacc caggctgg agtgcagtgg chr7:106684567-106684647 21 2.49e-05 ACATAATAAA CAGGATGG ATCGGGAAAG chr12:54717522-54717602 53 2.49e-05 tcttgttgcc caggctgg agtgcaatga chr7:106649205-106649285 65 2.49e-05 ccatgttggt caggctgg tctcgaac chr1:21348212-21348292 45 2.49e-05 ccatgttggg caggctgg tctcgaactc chr9:130921000-130921080 31 2.49e-05 ccatgttggt caggctgg tctcaaactc chr17:73422891-73422971 8 2.49e-05 tgtcacc caggctgg agtgcagtgg chr3:32823584-32823664 56 2.49e-05 ctttgtcgcc caggctgg agtgtagtgg chr3:44482610-44482690 5 2.49e-05 tggc caggctgg tctcaatctc chr15:79165887-79165967 57 5.41e-05 ATGGCCGTTG CAAGATGG CGGCGCCATC chr12:92733153-92733233 21 5.41e-05 gggccactcc caagatgg cagcaagcct chrX:950807-950887 34 5.41e-05 tagacacgtt caagatgg cggctccatc chr5:81581689-81581769 41 5.41e-05 ttaactggcc caagatgg ttgatagagc chr19:52511473-52511553 20 5.41e-05 TGCGCAGATG CAAGATGG CCGCGCCCTC chr1:161190657-161190737 27 5.41e-05 TTCCAGGCTC CAAGATGG CTACCAGGCC chr6:89130734-89130814 36 5.41e-05 gggccacttc caagatgg tggcaagccc chrX:2243319-2243399 32 5.41e-05 tagacacgtt caagatgg cggctccatc chr21:21420591-21420671 51 5.41e-05 gggccactcc caagatgg tggcaggcca chr20:61966632-61966712 47 5.41e-05 CCCTTCACCA CAAGATGG CGGATCCCAG chr22:20829858-20829938 33 5.41e-05 ctctgttgcc caagctgg agtgcagcag chr22:19284946-19285026 27 7.83e-05 tacttcactc cagcctgg gcaacacaga chr3:37270897-37270977 21 7.83e-05 gattcaagac cagcctgg gcaatataat chr7:116568141-116568221 56 7.83e-05 agctacactc cagcctgg gcaacagagc chr22:19408590-19408670 34 7.83e-05 agttcaaaac cagcctgg ccaacatggt chr6:27636845-27636925 18 7.83e-05 catagtaccc cagcctgg gcctgggcaa chr15:40675034-40675114 46 1.07e-04 GTTTTCCGTA CAACATGG CTGTCTACAG chr7:100108893-100108973 6 1.07e-04 ctggg caacatgg agaaaccctg chr20:5730940-5731020 38 1.37e-04 TGCCCGCAGT AAGGATGG CTCCGGTGAC chr3:119187708-119187788 6 1.37e-04 GCCTC AAGGCTGG GGACTGGAGG chr19:59085368-59085448 61 1.66e-04 GAAGGAAACG CAGAATGG GTTCACAGAG chr22:19080366-19080446 6 1.66e-04 ttcaa cagaatgg tactgCGAAA chr19:50316865-50316945 1 2.01e-04 . AAAGATGG CGACCGTGGC chr19:49127311-49127391 70 2.01e-04 CTCCCTTAAC AAAGATGG CGA chr10:99639226-99639306 69 2.01e-04 TTCCCTTTTC AAAGATGG CCAC chr3:57741774-57741854 40 2.36e-04 TGCCCTTAAC CAAAATGG TCGTTAAGGT chr18:73424439-73424519 50 2.36e-04 CTCTCAGATC CAAAATGG CTGCTGCATG chr11:62477132-62477212 66 2.36e-04 CTTCTGGTCT CAAAATGG CTGCCCC chr16:19566852-19566932 48 2.65e-04 TGCCCCTCAC AAGCATGG CGTCTGCAGA chr1:21469655-21469735 56 2.65e-04 cactgtactc aagcctgg gcgacaaagt chr16:89087191-89087271 16 2.65e-04 acctcccacc aagcctgg ctattttttt -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CARGMTGG MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr14:23480434-23480514 2.5e-05 4_[+4]_68 chr7:66461005-66461085 2.5e-05 55_[+4]_17 chr7:106684567-106684647 2.5e-05 20_[+4]_52 chr12:54717522-54717602 2.5e-05 52_[+4]_20 chr7:106649205-106649285 2.5e-05 64_[+4]_8 chr1:21348212-21348292 2.5e-05 44_[+4]_28 chr9:130921000-130921080 2.5e-05 30_[+4]_42 chr17:73422891-73422971 2.5e-05 7_[+4]_65 chr3:32823584-32823664 2.5e-05 55_[+4]_17 chr3:44482610-44482690 2.5e-05 4_[+4]_68 chr15:79165887-79165967 5.4e-05 56_[+4]_16 chr12:92733153-92733233 5.4e-05 20_[+4]_52 chrX:950807-950887 5.4e-05 33_[+4]_39 chr5:81581689-81581769 5.4e-05 40_[+4]_32 chr19:52511473-52511553 5.4e-05 19_[+4]_53 chr1:161190657-161190737 5.4e-05 26_[+4]_46 chr6:89130734-89130814 5.4e-05 35_[+4]_37 chrX:2243319-2243399 5.4e-05 31_[+4]_41 chr21:21420591-21420671 5.4e-05 50_[+4]_22 chr20:61966632-61966712 5.4e-05 46_[+4]_26 chr22:20829858-20829938 5.4e-05 32_[+4]_40 chr22:19284946-19285026 7.8e-05 26_[+4]_46 chr3:37270897-37270977 7.8e-05 20_[+4]_52 chr7:116568141-116568221 7.8e-05 55_[+4]_17 chr22:19408590-19408670 7.8e-05 33_[+4]_39 chr6:27636845-27636925 7.8e-05 17_[+4]_55 chr15:40675034-40675114 0.00011 45_[+4]_27 chr7:100108893-100108973 0.00011 5_[+4]_67 chr20:5730940-5731020 0.00014 37_[+4]_35 chr3:119187708-119187788 0.00014 5_[+4]_67 chr19:59085368-59085448 0.00017 60_[+4]_12 chr22:19080366-19080446 0.00017 5_[+4]_67 chr19:50316865-50316945 0.0002 [+4]_72 chr19:49127311-49127391 0.0002 69_[+4]_3 chr10:99639226-99639306 0.0002 68_[+4]_4 chr3:57741774-57741854 0.00024 39_[+4]_33 chr18:73424439-73424519 0.00024 49_[+4]_23 chr11:62477132-62477212 0.00024 65_[+4]_7 chr16:19566852-19566932 0.00026 47_[+4]_25 chr1:21469655-21469735 0.00026 55_[+4]_17 chr16:89087191-89087271 0.00026 15_[+4]_57 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CARGMTGG MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CARGMTGG width=8 seqs=41 chr14:23480434-23480514 ( 5) CAGGCTGG 1 chr7:66461005-66461085 ( 56) CAGGCTGG 1 chr7:106684567-106684647 ( 21) CAGGATGG 1 chr12:54717522-54717602 ( 53) CAGGCTGG 1 chr7:106649205-106649285 ( 65) CAGGCTGG 1 chr1:21348212-21348292 ( 45) CAGGCTGG 1 chr9:130921000-130921080 ( 31) CAGGCTGG 1 chr17:73422891-73422971 ( 8) CAGGCTGG 1 chr3:32823584-32823664 ( 56) CAGGCTGG 1 chr3:44482610-44482690 ( 5) CAGGCTGG 1 chr15:79165887-79165967 ( 57) CAAGATGG 1 chr12:92733153-92733233 ( 21) CAAGATGG 1 chrX:950807-950887 ( 34) CAAGATGG 1 chr5:81581689-81581769 ( 41) CAAGATGG 1 chr19:52511473-52511553 ( 20) CAAGATGG 1 chr1:161190657-161190737 ( 27) CAAGATGG 1 chr6:89130734-89130814 ( 36) CAAGATGG 1 chrX:2243319-2243399 ( 32) CAAGATGG 1 chr21:21420591-21420671 ( 51) CAAGATGG 1 chr20:61966632-61966712 ( 47) CAAGATGG 1 chr22:20829858-20829938 ( 33) CAAGCTGG 1 chr22:19284946-19285026 ( 27) CAGCCTGG 1 chr3:37270897-37270977 ( 21) CAGCCTGG 1 chr7:116568141-116568221 ( 56) CAGCCTGG 1 chr22:19408590-19408670 ( 34) CAGCCTGG 1 chr6:27636845-27636925 ( 18) CAGCCTGG 1 chr15:40675034-40675114 ( 46) CAACATGG 1 chr7:100108893-100108973 ( 6) CAACATGG 1 chr20:5730940-5731020 ( 38) AAGGATGG 1 chr3:119187708-119187788 ( 6) AAGGCTGG 1 chr19:59085368-59085448 ( 61) CAGAATGG 1 chr22:19080366-19080446 ( 6) CAGAATGG 1 chr19:50316865-50316945 ( 1) AAAGATGG 1 chr19:49127311-49127391 ( 70) AAAGATGG 1 chr10:99639226-99639306 ( 69) AAAGATGG 1 chr3:57741774-57741854 ( 40) CAAAATGG 1 chr18:73424439-73424519 ( 50) CAAAATGG 1 chr11:62477132-62477212 ( 66) CAAAATGG 1 chr16:19566852-19566932 ( 48) AAGCATGG 1 chr1:21469655-21469735 ( 56) AAGCCTGG 1 chr16:89087191-89087271 ( 16) AAGCCTGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CARGMTGG MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.2866 E= 7.1e-009 -50 182 -1200 -1200 186 -1200 -1200 -1200 75 -1200 120 -1200 -117 10 144 -1200 103 94 -1200 -1200 -1200 -1200 -1200 193 -1200 -1200 210 -1200 -1200 -1200 210 -1200 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CARGMTGG MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 41 E= 7.1e-009 0.195122 0.804878 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.463415 0.000000 0.536585 0.000000 0.121951 0.243902 0.634146 0.000000 0.560976 0.439024 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CARGMTGG MEME-4 regular expression -------------------------------------------------------------------------------- CA[GA][GC][AC]TGG -------------------------------------------------------------------------------- Time 16.52 secs. ******************************************************************************** ******************************************************************************** MOTIF AAAGARAR MEME-5 width = 8 sites = 64 llr = 473 E-value = 7.6e-006 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAAGARAR MEME-5 Description -------------------------------------------------------------------------------- Simplified A a88397a7 pos.-specific C :::::::: probability G :32713:3 matrix T :::::::: bits 2.1 1.9 * * 1.7 * * 1.5 * * Relative 1.3 * *** * Entropy 1.1 ******** (10.7 bits) 0.9 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AAAGAAAA consensus G A G G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGARAR MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:19284946-19285026 63 2.78e-05 ctgtctcaaa aaagaaaa gggaagggaa chr6:26170113-26170193 36 2.78e-05 aaaaaaagaa AAAGAAAA AGGGGGGTGA chr12:94132542-94132622 27 2.78e-05 CTCTGACTag aaagaaaa agagaagaga chr7:139316170-139316250 21 2.78e-05 agaaaggaat aaagaaaa aaTAGCAAGG chr1:142832091-142832171 38 2.78e-05 aaaaagaaaa aaagaaaa acaaaaaaaG chr1:47695699-47695779 25 2.78e-05 agagacagaa aaagaaaa ggaaataaag chr22:19815033-19815113 12 2.78e-05 gcaaacaccg aaagaaaa ataagcaaaa chr7:72195532-72195612 5 2.78e-05 gaga aaagaaaa agaaaaggaa chr12:28275352-28275432 11 2.78e-05 aagaaagaaa aaagaaaa gaaaaagaaa chr22:19080366-19080446 32 2.78e-05 AACACggaag aaagaaaa atgaagagga chr7:121051202-121051282 53 2.78e-05 AAATTGAAAT AAAGAAAA GTAACAGAAA chr3:37270897-37270977 59 2.78e-05 ctcaagaaag aaagaaaa gaagaaagaa chr1:247093401-247093481 1 2.78e-05 . AAAGAAAA CAAAAGTCTC chr1:3815704-3815784 10 2.78e-05 gacttgtat aaagaaaa gaaaaagtaa chr7:106647292-106647372 32 2.78e-05 TACCCCTGAG AAAGAAAA CACATGGAAC chr2:26633641-26633721 8 7.52e-05 tgagaat aaagagaa agggcctacg chr7:106684567-106684647 62 7.52e-05 TGGGGAAGAA AAAGAAAG ACGTCACAAA chr8:38007929-38008009 54 7.52e-05 agaaaggaag aaagaaag gaaaggaagg chr10:99639226-99639306 11 7.52e-05 GAAAACATGC AAAGAAAG TCTTCACAAA chr1:145066981-145067061 2 7.52e-05 t aaagagaa aaatttataa chr10:29101643-29101723 50 7.52e-05 agaaagaaag aaagaaag agaacgaaag chr6:154827396-154827476 25 7.52e-05 atgaaaagga aaagaaag gaaaagagag chr1:193091947-193092027 5 9.89e-05 TAGA AGAGAAAA GGGAATCAAC chr19:7805633-7805713 43 1.19e-04 ACAGCAGAGG AAAGAGAG AGAGGAGGAG chr6:138184952-138185032 52 1.19e-04 ACAGTCTCAG AAAGAGAG TGTCACTGAT chr7:151202155-151202235 37 1.52e-04 tgaaaacaaa aaaaaaaa caactttatg chr1:117601892-117601972 55 1.52e-04 GCATAATAGT AAAAAAAA GTTTGACAAT chr6:10886463-10886543 14 1.52e-04 CTTTGATTAA AAAAAAAA ATTCCCCTTC chr10:52142351-52142431 26 1.52e-04 ATTCTGACCA AAAAAAAA ACACACACAC chr18:3012177-3012257 8 1.52e-04 TCAATTA AAAAAAAA ATGGGTAAGC chr2:145273040-145273120 28 1.52e-04 ACCAGAGTGA AAAAAAAA TTAAATTAag chr21:46938631-46938711 1 1.52e-04 . aaaaaaaa gaacactgtc chr22:19802552-19802632 8 1.52e-04 tgcctca aaaaaaaa aaaaagacca chr18:9918448-9918528 71 1.52e-04 cagtttctct aaaaaaaa cc chr13:93886919-93886999 68 1.92e-04 gggaaggaag agagagaa gagag chr12:122492751-12249283 15 1.92e-04 TGAACAGCTC AGAGAAAG TAGATCGGCA chr5:39016447-39016527 20 1.92e-04 agagggagga agagaaag gtgacaagga chr21:39448093-39448173 56 1.92e-04 ggaatgagag agagaaag gagagagaga chr3:33493664-33493744 72 1.92e-04 aaggagtcag agagaaag a chr1:160176353-160176433 56 1.92e-04 CCCAAGTCAG AGAGAGAA TGAGAGGAAT chr21:38710792-38710872 38 2.16e-04 TTGTAATTAT AAGGAAAA CTATGCACGG chr11:5146377-5146457 1 2.71e-04 . aaaaagaa atctttaggc chr19:59085368-59085448 6 3.12e-04 TAGCA AGAGAGAG GCAGATCAGA chr7:1463242-1463322 45 3.12e-04 agatggaggg agagagag acagagaggg chr3:183602224-183602304 71 3.80e-04 CCCAATGGGA AAGGAGAA AG chr10:50399641-50399721 2 3.80e-04 c agaaaaaa ggcagaagaa chr2:174602592-174602672 5 3.80e-04 aagg aaggaaag aaggaagata chr10:74263631-74263711 73 3.80e-04 agatctctac aaggagaa chr1:220081383-220081463 32 3.80e-04 GAGAAGAGTC AAGGAAAG CTGATTTCAA chr6:33396703-33396783 46 4.44e-04 AAAAGCTTAA aaagggaa gaaatggggt chr12:92075984-92076064 11 4.44e-04 aaccctgggg aaagggaa gaatctgcta chr6:26283783-26283863 2 5.77e-04 A AGAGGAAA AATCTGATTT chr2:26296732-26296812 34 5.94e-04 CAATATAAAT AAAGGGAG ATTACAATGG chr7:100401571-100401651 57 5.94e-04 TAAGGGGAAA AAAGGGAG AGGAGGCCCC chr1:24745432-24745512 45 5.94e-04 AGCTATGGAA AAAGGGAG GATTTAAGTT chr1:28367112-28367192 19 6.56e-04 aagtactgag agggagaa tgtgaggaga chr6:161468638-161468718 21 6.56e-04 gagatcaccc agggagaa gagatctaag chr1:108623429-108623509 4 6.76e-04 tta agaaagag tgcttttcac chr7:35042791-35042871 65 6.76e-04 aaataaacca agaaagag gaacaaac chr6:147480840-147480920 10 7.24e-04 TGGTGCAAG AAGAAAAG GACTCAAAAA chr6:7030258-7030338 72 7.24e-04 caagacaaat aagaagaa a chr5:36881248-36881328 20 8.40e-04 TGGTTGATTT AAAAGGAA TTTTAAACTC chr10:75575523-75575603 72 8.40e-04 GGGAAAAGGC AAAAGAAG T chr8:105630570-105630650 70 8.64e-04 GGAGATCAAT AGGAAAAA TGa -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGARAR MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:19284946-19285026 2.8e-05 62_[+5]_10 chr6:26170113-26170193 2.8e-05 35_[+5]_37 chr12:94132542-94132622 2.8e-05 26_[+5]_46 chr7:139316170-139316250 2.8e-05 20_[+5]_52 chr1:142832091-142832171 2.8e-05 37_[+5]_35 chr1:47695699-47695779 2.8e-05 24_[+5]_48 chr22:19815033-19815113 2.8e-05 11_[+5]_61 chr7:72195532-72195612 2.8e-05 4_[+5]_68 chr12:28275352-28275432 2.8e-05 10_[+5]_62 chr22:19080366-19080446 2.8e-05 31_[+5]_41 chr7:121051202-121051282 2.8e-05 52_[+5]_20 chr3:37270897-37270977 2.8e-05 58_[+5]_14 chr1:247093401-247093481 2.8e-05 [+5]_72 chr1:3815704-3815784 2.8e-05 9_[+5]_63 chr7:106647292-106647372 2.8e-05 31_[+5]_41 chr2:26633641-26633721 7.5e-05 7_[+5]_65 chr7:106684567-106684647 7.5e-05 61_[+5]_11 chr8:38007929-38008009 7.5e-05 53_[+5]_19 chr10:99639226-99639306 7.5e-05 10_[+5]_62 chr1:145066981-145067061 7.5e-05 1_[+5]_71 chr10:29101643-29101723 7.5e-05 49_[+5]_23 chr6:154827396-154827476 7.5e-05 24_[+5]_48 chr1:193091947-193092027 9.9e-05 4_[+5]_68 chr19:7805633-7805713 0.00012 42_[+5]_30 chr6:138184952-138185032 0.00012 51_[+5]_21 chr7:151202155-151202235 0.00015 36_[+5]_36 chr1:117601892-117601972 0.00015 54_[+5]_18 chr6:10886463-10886543 0.00015 13_[+5]_59 chr10:52142351-52142431 0.00015 25_[+5]_47 chr18:3012177-3012257 0.00015 7_[+5]_65 chr2:145273040-145273120 0.00015 27_[+5]_45 chr21:46938631-46938711 0.00015 [+5]_72 chr22:19802552-19802632 0.00015 7_[+5]_65 chr18:9918448-9918528 0.00015 70_[+5]_2 chr13:93886919-93886999 0.00019 67_[+5]_5 chr12:122492751-12249283 0.00019 14_[+5]_58 chr5:39016447-39016527 0.00019 19_[+5]_53 chr21:39448093-39448173 0.00019 55_[+5]_17 chr3:33493664-33493744 0.00019 71_[+5]_1 chr1:160176353-160176433 0.00019 55_[+5]_17 chr21:38710792-38710872 0.00022 37_[+5]_35 chr11:5146377-5146457 0.00027 [+5]_72 chr19:59085368-59085448 0.00031 5_[+5]_67 chr7:1463242-1463322 0.00031 44_[+5]_28 chr3:183602224-183602304 0.00038 70_[+5]_2 chr10:50399641-50399721 0.00038 1_[+5]_71 chr2:174602592-174602672 0.00038 4_[+5]_68 chr10:74263631-74263711 0.00038 72_[+5] chr1:220081383-220081463 0.00038 31_[+5]_41 chr6:33396703-33396783 0.00044 45_[+5]_27 chr12:92075984-92076064 0.00044 10_[+5]_62 chr6:26283783-26283863 0.00058 1_[+5]_71 chr2:26296732-26296812 0.00059 33_[+5]_39 chr7:100401571-100401651 0.00059 56_[+5]_16 chr1:24745432-24745512 0.00059 44_[+5]_28 chr1:28367112-28367192 0.00066 18_[+5]_54 chr6:161468638-161468718 0.00066 20_[+5]_52 chr1:108623429-108623509 0.00068 3_[+5]_69 chr7:35042791-35042871 0.00068 64_[+5]_8 chr6:147480840-147480920 0.00072 9_[+5]_63 chr6:7030258-7030338 0.00072 71_[+5]_1 chr5:36881248-36881328 0.00084 19_[+5]_53 chr10:75575523-75575603 0.00084 71_[+5]_1 chr8:105630570-105630650 0.00086 69_[+5]_3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGARAR MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAAGARAR width=8 seqs=64 chr22:19284946-19285026 ( 63) AAAGAAAA 1 chr6:26170113-26170193 ( 36) AAAGAAAA 1 chr12:94132542-94132622 ( 27) AAAGAAAA 1 chr7:139316170-139316250 ( 21) AAAGAAAA 1 chr1:142832091-142832171 ( 38) AAAGAAAA 1 chr1:47695699-47695779 ( 25) AAAGAAAA 1 chr22:19815033-19815113 ( 12) AAAGAAAA 1 chr7:72195532-72195612 ( 5) AAAGAAAA 1 chr12:28275352-28275432 ( 11) AAAGAAAA 1 chr22:19080366-19080446 ( 32) AAAGAAAA 1 chr7:121051202-121051282 ( 53) AAAGAAAA 1 chr3:37270897-37270977 ( 59) AAAGAAAA 1 chr1:247093401-247093481 ( 1) AAAGAAAA 1 chr1:3815704-3815784 ( 10) AAAGAAAA 1 chr7:106647292-106647372 ( 32) AAAGAAAA 1 chr2:26633641-26633721 ( 8) AAAGAGAA 1 chr7:106684567-106684647 ( 62) AAAGAAAG 1 chr8:38007929-38008009 ( 54) AAAGAAAG 1 chr10:99639226-99639306 ( 11) AAAGAAAG 1 chr1:145066981-145067061 ( 2) AAAGAGAA 1 chr10:29101643-29101723 ( 50) AAAGAAAG 1 chr6:154827396-154827476 ( 25) AAAGAAAG 1 chr1:193091947-193092027 ( 5) AGAGAAAA 1 chr19:7805633-7805713 ( 43) AAAGAGAG 1 chr6:138184952-138185032 ( 52) AAAGAGAG 1 chr7:151202155-151202235 ( 37) AAAAAAAA 1 chr1:117601892-117601972 ( 55) AAAAAAAA 1 chr6:10886463-10886543 ( 14) AAAAAAAA 1 chr10:52142351-52142431 ( 26) AAAAAAAA 1 chr18:3012177-3012257 ( 8) AAAAAAAA 1 chr2:145273040-145273120 ( 28) AAAAAAAA 1 chr21:46938631-46938711 ( 1) AAAAAAAA 1 chr22:19802552-19802632 ( 8) AAAAAAAA 1 chr18:9918448-9918528 ( 71) AAAAAAAA 1 chr13:93886919-93886999 ( 68) AGAGAGAA 1 chr12:122492751-12249283 ( 15) AGAGAAAG 1 chr5:39016447-39016527 ( 20) AGAGAAAG 1 chr21:39448093-39448173 ( 56) AGAGAAAG 1 chr3:33493664-33493744 ( 72) AGAGAAAG 1 chr1:160176353-160176433 ( 56) AGAGAGAA 1 chr21:38710792-38710872 ( 38) AAGGAAAA 1 chr11:5146377-5146457 ( 1) AAAAAGAA 1 chr19:59085368-59085448 ( 6) AGAGAGAG 1 chr7:1463242-1463322 ( 45) AGAGAGAG 1 chr3:183602224-183602304 ( 71) AAGGAGAA 1 chr10:50399641-50399721 ( 2) AGAAAAAA 1 chr2:174602592-174602672 ( 5) AAGGAAAG 1 chr10:74263631-74263711 ( 73) AAGGAGAA 1 chr1:220081383-220081463 ( 32) AAGGAAAG 1 chr6:33396703-33396783 ( 46) AAAGGGAA 1 chr12:92075984-92076064 ( 11) AAAGGGAA 1 chr6:26283783-26283863 ( 2) AGAGGAAA 1 chr2:26296732-26296812 ( 34) AAAGGGAG 1 chr7:100401571-100401651 ( 57) AAAGGGAG 1 chr1:24745432-24745512 ( 45) AAAGGGAG 1 chr1:28367112-28367192 ( 19) AGGGAGAA 1 chr6:161468638-161468718 ( 21) AGGGAGAA 1 chr1:108623429-108623509 ( 4) AGAAAGAG 1 chr7:35042791-35042871 ( 65) AGAAAGAG 1 chr6:147480840-147480920 ( 10) AAGAAAAG 1 chr6:7030258-7030338 ( 72) AAGAAGAA 1 chr5:36881248-36881328 ( 20) AAAAGGAA 1 chr10:75575523-75575603 ( 72) AAAAGAAG 1 chr8:105630570-105630650 ( 70) AGGAAAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGARAR MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.47551 E= 7.6e-006 186 -1264 -1264 -1264 145 -1264 10 -1264 162 -1264 -58 -1264 3 -1264 162 -1264 167 -1264 -90 -1264 125 -1264 56 -1264 186 -1264 -1264 -1264 125 -1264 56 -1264 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGARAR MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 64 E= 7.6e-006 1.000000 0.000000 0.000000 0.000000 0.750000 0.000000 0.250000 0.000000 0.843750 0.000000 0.156250 0.000000 0.281250 0.000000 0.718750 0.000000 0.875000 0.000000 0.125000 0.000000 0.656250 0.000000 0.343750 0.000000 1.000000 0.000000 0.000000 0.000000 0.656250 0.000000 0.343750 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGARAR MEME-5 regular expression -------------------------------------------------------------------------------- A[AG]A[GA]A[AG]A[AG] -------------------------------------------------------------------------------- Time 20.22 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:1949560-1949640 4.65e-02 80 chrX:1567439-1567519 8.13e-02 18_[+1(4.44e-05)]_8_[+1(4.44e-05)]_\ 11_[+1(1.39e-05)]_11_[+1(4.44e-05)] chr22:20829858-20829938 3.19e-02 32_[+4(5.41e-05)]_40 chr20:61966632-61966712 1.35e-02 18_[+4(5.41e-05)]_20_[+4(5.41e-05)]_\ 26 chr6:161468638-161468718 4.59e-01 80 chr1:39250506-39250586 4.92e-01 80 chr7:134270844-134270924 6.29e-04 25_[+1(1.39e-05)]_13_[+1(4.44e-05)]_\ 13_[+1(4.44e-05)]_5 chrX:1566482-1566562 7.60e-02 4_[+1(4.44e-05)]_11_[+1(1.39e-05)]_\ 11_[+1(4.44e-05)]_8_[+1(4.44e-05)]_14 chr4:155113932-155114012 4.19e-03 24_[+1(2.81e-05)]_13_[+1(4.44e-05)]_\ 14_[+1(1.39e-05)]_5 chr1:160176353-160176433 7.66e-02 80 chr21:21420591-21420671 2.44e-02 6_[+4(5.41e-05)]_14_[+4(5.41e-05)]_\ 14_[+4(5.41e-05)]_14_[+4(5.41e-05)] chr7:150658626-150658706 4.20e-04 5_[+2(9.97e-06)]_1_[+3(1.04e-05)]_\ 58 chr1:245836494-245836574 2.99e-02 24_[+1(1.39e-05)]_37_[+1(1.39e-05)]_\ 3 chr11:9575772-9575852 5.08e-01 80 chr6:164006567-164006647 1.59e-03 41_[+3(8.19e-05)]_15_[+2(9.97e-06)]_\ 8 chr22:21944570-21944650 8.18e-04 2_[+3(1.93e-05)]_15_[+2(9.97e-06)]_\ 1_[+3(1.93e-05)]_38 chr1:246316042-246316122 6.14e-02 58_[+2(7.37e-05)]_14 chr22:17087107-17087187 1.14e-04 63_[+3(1.04e-05)]_9 chr1:12496805-12496885 5.12e-04 5_[+3(1.04e-05)]_15_[+2(9.97e-06)]_\ 1_[+3(1.93e-05)]_35 chr6:29936014-29936094 9.25e-01 80 chr7:106647292-106647372 9.63e-03 31_[+5(2.78e-05)]_41 chr6:154827396-154827476 2.43e-01 24_[+5(7.52e-05)]_48 chr7:20347817-20347897 2.23e-01 16_[+1(5.59e-05)]_56 chr3:44482610-44482690 1.43e-04 4_[+4(2.49e-05)]_35_[+3(1.04e-05)]_\ 25 chr16:89087191-89087271 2.48e-03 5_[+3(4.08e-05)]_67 chr6:27636845-27636925 3.34e-02 17_[+4(7.83e-05)]_55 chr20:36034596-36034676 7.89e-01 80 chr3:32823584-32823664 2.12e-02 55_[+4(2.49e-05)]_17 chr1:26612687-26612767 7.66e-01 80 chr6:43132530-43132610 6.42e-01 80 chr11:62477132-62477212 6.48e-04 50_[+1(5.59e-05)]_22 chr6:138184952-138185032 5.19e-02 80 chrX:47225757-47225837 5.59e-02 46_[+3(5.94e-05)]_26 chr20:49050008-49050088 1.60e-01 80 chr18:9918448-9918528 5.69e-03 80 chr18:3665319-3665399 4.82e-01 80 chr22:22254880-22254960 8.75e-01 80 chr15:96104812-96104892 2.46e-01 80 chr5:139135120-139135200 3.81e-01 80 chrX:2243319-2243399 2.65e-03 31_[+4(5.41e-05)]_41 chr6:28458455-28458535 6.85e-01 80 chr6:89130734-89130814 1.07e-01 35_[+4(5.41e-05)]_37 chr1:220081383-220081463 6.56e-02 80 chr7:148786932-148787012 1.58e-02 22_[+1(7.04e-05)]_50 chr6:7030258-7030338 5.04e-01 80 chr1:161190657-161190737 2.62e-02 26_[+4(5.41e-05)]_46 chr8:105630570-105630650 5.90e-01 80 chr19:14496165-14496245 7.23e-01 80 chr7:106706708-106706788 9.98e-01 80 chr22:20060024-20060104 2.94e-04 69_[+3(1.04e-05)]_3 chr5:64778116-64778196 5.52e-01 80 chr6:3163963-3164043 4.81e-01 80 chr17:73422891-73422971 2.48e-04 7_[+4(2.49e-05)]_65 chr11:5146377-5146457 3.69e-01 80 chr15:35265301-35265381 7.93e-01 80 chr18:73424439-73424519 1.73e-01 80 chr10:74263631-74263711 2.44e-01 80 chr22:22044932-22045012 9.83e-02 34_[+2(2.12e-05)]_38 chr1:27889685-27889765 3.86e-01 80 chr8:66776788-66776868 7.46e-03 80 chr9:130921000-130921080 5.96e-05 30_[+4(2.49e-05)]_26_[+2(2.98e-05)]_\ 8 chr22:19768532-19768612 6.24e-05 16_[+2(2.98e-05)]_1_[+3(1.04e-05)]_\ 47 chr18:9886117-9886197 8.05e-01 80 chr3:33493664-33493744 5.15e-01 80 chr5:148929112-148929192 1.61e-02 46_[+1(8.64e-05)]_26 chrX:153236458-153236538 1.20e-02 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