******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/CEBPZ.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr6:68790113-68790193 1.0000 80 chr18:64967862-64967942 1.0000 80 chr11:69149875-69149955 1.0000 80 chr1:196504992-196505072 1.0000 80 chr11:59936928-59937008 1.0000 80 chr10:72408389-72408469 1.0000 80 chr17:58635383-58635463 1.0000 80 chr7:146207333-146207413 1.0000 80 chrX:46988603-46988683 1.0000 80 chr4:48782431-48782511 1.0000 80 chr4:84299752-84299832 1.0000 80 chr7:73762050-73762130 1.0000 80 chr19:11457022-11457102 1.0000 80 chr1:25757194-25757274 1.0000 80 chr6:147286393-147286473 1.0000 80 chr10:104261969-10426204 1.0000 80 chr20:45035305-45035385 1.0000 80 chr16:90121119-90121199 1.0000 80 chr22:37172211-37172291 1.0000 80 chr19:36193341-36193421 1.0000 80 chr4:41296618-41296698 1.0000 80 chr2:62504974-62505054 1.0000 80 chr8:145159253-145159333 1.0000 80 chr11:107798882-10779896 1.0000 80 chr2:71454302-71454382 1.0000 80 chr13:20532724-20532804 1.0000 80 chr10:72411567-72411647 1.0000 80 chr4:52709128-52709208 1.0000 80 chr17:39943145-39943225 1.0000 80 chr21:47604557-47604637 1.0000 80 chr1:113932898-113932978 1.0000 80 chr22:35696153-35696233 1.0000 80 chr1:151254567-151254647 1.0000 80 chr7:2884050-2884130 1.0000 80 chr5:171847690-171847770 1.0000 80 chr1:151334991-151335071 1.0000 80 chr2:44395622-44395702 1.0000 80 chr1:61543722-61543802 1.0000 80 chr17:74667893-74667973 1.0000 80 chr19:19174454-19174534 1.0000 80 chr14:96001179-96001259 1.0000 80 chr17:4870673-4870753 1.0000 80 chr5:59009102-59009182 1.0000 80 chr6:119404342-119404422 1.0000 80 chr22:29999342-29999422 1.0000 80 chr19:13906048-13906128 1.0000 80 chr19:54641269-54641349 1.0000 80 chr5:68228801-68228881 1.0000 80 chr16:1728094-1728174 1.0000 80 chr3:33007192-33007272 1.0000 80 chr3:193432496-193432576 1.0000 80 chr2:73460461-73460541 1.0000 80 chr6:32146015-32146095 1.0000 80 chr9:135905900-135905980 1.0000 80 chr1:168233682-168233762 1.0000 80 chr12:113658920-11365900 1.0000 80 chr9:96891020-96891100 1.0000 80 chr1:227473630-227473710 1.0000 80 chr14:23790516-23790596 1.0000 80 chr22:21996434-21996514 1.0000 80 chr15:75744241-75744321 1.0000 80 chr11:68228033-68228113 1.0000 80 chr3:88108232-88108312 1.0000 80 chr1:45723868-45723948 1.0000 80 chr14:104181862-10418194 1.0000 80 chr11:74255212-74255292 1.0000 80 chr4:84886451-84886531 1.0000 80 chr22:40440674-40440754 1.0000 80 chr10:1026633-1026713 1.0000 80 chr13:91304433-91304513 1.0000 80 chrX:49125725-49125805 1.0000 80 chr14:78083257-78083337 1.0000 80 chr19:14228668-14228748 1.0000 80 chr9:124133575-124133655 1.0000 80 chr11:75759977-75760057 1.0000 80 chr19:50379500-50379580 1.0000 80 chr1:38397514-38397594 1.0000 80 chr6:80247190-80247270 1.0000 80 chr2:6985634-6985714 1.0000 80 chr19:6292200-6292280 1.0000 80 chr7:86834437-86834517 1.0000 80 chr3:194489976-194490056 1.0000 80 chr6:99474201-99474281 1.0000 80 chr17:46125544-46125624 1.0000 80 chr1:205124940-205125020 1.0000 80 chrX:49047657-49047737 1.0000 80 chr11:67275739-67275819 1.0000 80 chr9:90070478-90070558 1.0000 80 chr1:6845266-6845346 1.0000 80 chr19:2945014-2945094 1.0000 80 chr16:16075435-16075515 1.0000 80 chr11:63953437-63953517 1.0000 80 chr16:639263-639343 1.0000 80 chr7:100825844-100825924 1.0000 80 chr9:128003812-128003892 1.0000 80 chr17:61627663-61627743 1.0000 80 chr14:73925421-73925501 1.0000 80 chr7:100184146-100184226 1.0000 80 chr19:18315100-18315180 1.0000 80 chr9:139780750-139780830 1.0000 80 chr1:12282943-12283023 1.0000 80 chr19:3971230-3971310 1.0000 80 chr18:77782817-77782897 1.0000 80 chr5:103521919-103521999 1.0000 80 chr19:12405695-12405775 1.0000 80 chr18:71959278-71959358 1.0000 80 chr11:62599191-62599271 1.0000 80 chr2:149011446-149011526 1.0000 80 chr13:20437846-20437926 1.0000 80 chr19:45394320-45394400 1.0000 80 chr3:183371133-183371213 1.0000 80 chr11:62521651-62521731 1.0000 80 chr14:62129365-62129445 1.0000 80 chr13:41722989-41723069 1.0000 80 chr1:117664452-117664532 1.0000 80 chr19:36505196-36505276 1.0000 80 chr1:109328064-109328144 1.0000 80 chr19:19496435-19496515 1.0000 80 chr11:59383423-59383503 1.0000 80 chr16:57769491-57769571 1.0000 80 chr11:77566140-77566220 1.0000 80 chr1:150601659-150601739 1.0000 80 chr22:47152133-47152213 1.0000 80 chr2:88927169-88927249 1.0000 80 chr19:42901154-42901234 1.0000 80 chr17:17875940-17876020 1.0000 80 chr2:39587011-39587091 1.0000 80 chr19:11485700-11485780 1.0000 80 chr5:32313272-32313352 1.0000 80 chr21:39601334-39601414 1.0000 80 chr10:101380282-10138036 1.0000 80 chr3:133511123-133511203 1.0000 80 chr19:36248876-36248956 1.0000 80 chr9:130159274-130159354 1.0000 80 chr19:46498529-46498609 1.0000 80 chr17:47866526-47866606 1.0000 80 chr17:41397316-41397396 1.0000 80 chr19:42773325-42773405 1.0000 80 chr14:21737706-21737786 1.0000 80 chr19:4472094-4472174 1.0000 80 chr2:136288863-136288943 1.0000 80 chr17:26368560-26368640 1.0000 80 chrX:107062268-107062348 1.0000 80 chr10:42863507-42863587 1.0000 80 chr9:34989531-34989611 1.0000 80 chr6:153168157-153168237 1.0000 80 chr7:77427864-77427944 1.0000 80 chr5:159546585-159546665 1.0000 80 chr9:96928390-96928470 1.0000 80 chr5:37283511-37283591 1.0000 80 chr19:4968814-4968894 1.0000 80 chr19:51161507-51161587 1.0000 80 chr17:79196833-79196913 1.0000 80 chr4:24967443-24967523 1.0000 80 chr4:25225518-25225598 1.0000 80 chr9:35072698-35072778 1.0000 80 chr7:64869079-64869159 1.0000 80 chr20:44486063-44486143 1.0000 80 chr3:45112727-45112807 1.0000 80 chr10:58130656-58130736 1.0000 80 chr19:7894851-7894931 1.0000 80 chr19:46087711-46087791 1.0000 80 chr7:154518248-154518328 1.0000 80 chr17:8534188-8534268 1.0000 80 chr7:153273329-153273409 1.0000 80 chr5:176853359-176853439 1.0000 80 chr12:56367587-56367667 1.0000 80 chr1:153895511-153895591 1.0000 80 chr6:140948277-140948357 1.0000 80 chr3:128578539-128578619 1.0000 80 chr19:12662378-12662458 1.0000 80 chr12:53773606-53773686 1.0000 80 chr21:43780571-43780651 1.0000 80 chr2:65283343-65283423 1.0000 80 chr10:5207842-5207922 1.0000 80 chr19:50180328-50180408 1.0000 80 chr17:80325839-80325919 1.0000 80 chr16:53537313-53537393 1.0000 80 chr19:48972389-48972469 1.0000 80 chr21:45357335-45357415 1.0000 80 chr7:149226353-149226433 1.0000 80 chr11:67798027-67798107 1.0000 80 chr6:28324893-28324973 1.0000 80 chr16:22385998-22386078 1.0000 80 chr19:1205570-1205650 1.0000 80 chr11:71823448-71823528 1.0000 80 chr19:42580147-42580227 1.0000 80 chr19:42773086-42773166 1.0000 80 chr19:54663628-54663708 1.0000 80 chr2:119502523-119502603 1.0000 80 chr12:6961103-6961183 1.0000 80 chr19:47551918-47551998 1.0000 80 chr1:112290056-112290136 1.0000 80 chr1:93708968-93709048 1.0000 80 chr19:55973115-55973195 1.0000 80 chr19:12847762-12847842 1.0000 80 chr15:89631455-89631535 1.0000 80 chr6:68832117-68832197 1.0000 80 chr1:33938027-33938107 1.0000 80 chr3:195163915-195163995 1.0000 80 chr16:30382175-30382255 1.0000 80 chr22:38054418-38054498 1.0000 80 chr19:1633551-1633631 1.0000 80 chr9:130829724-130829804 1.0000 80 chr9:127905878-127905958 1.0000 80 chr1:173439901-173439981 1.0000 80 chr19:11485260-11485340 1.0000 80 chr17:58755077-58755157 1.0000 80 chrX:154444562-154444642 1.0000 80 chr19:6372600-6372680 1.0000 80 chr16:77224639-77224719 1.0000 80 chr19:7822394-7822474 1.0000 80 chr12:49504660-49504740 1.0000 80 chr19:18303793-18303873 1.0000 80 chr9:37465776-37465856 1.0000 80 chr12:56211752-56211832 1.0000 80 chr19:10828452-10828532 1.0000 80 chr17:38574302-38574382 1.0000 80 chr2:74685336-74685416 1.0000 80 chr19:14117232-14117312 1.0000 80 chr19:15529873-15529953 1.0000 80 chr19:6737719-6737799 1.0000 80 chr10:5932022-5932102 1.0000 80 chr2:220094384-220094464 1.0000 80 chr19:41284001-41284081 1.0000 80 chr20:3869901-3869981 1.0000 80 chr22:19304389-19304469 1.0000 80 chr5:5409428-5409508 1.0000 80 chr19:6425215-6425295 1.0000 80 chr4:175204380-175204460 1.0000 80 chr1:45140234-45140314 1.0000 80 chr1:244211631-244211711 1.0000 80 chr22:23030815-23030895 1.0000 80 chr6:137510163-137510243 1.0000 80 chr18:44711173-44711253 1.0000 80 chr9:133781995-133782075 1.0000 80 chr14:55779494-55779574 1.0000 80 chr16:11254655-11254735 1.0000 80 chr1:87479122-87479202 1.0000 80 chr9:136166486-136166566 1.0000 80 chr19:55850964-55851044 1.0000 80 chr7:150725381-150725461 1.0000 80 chr7:33578999-33579079 1.0000 80 chr3:33482160-33482240 1.0000 80 chr19:58960381-58960461 1.0000 80 chr12:2921697-2921777 1.0000 80 chr2:62081714-62081794 1.0000 80 chr21:39595968-39596048 1.0000 80 chr2:97523833-97523913 1.0000 80 chr4:2433878-2433958 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_CEBPZ/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/CEBPZ.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.218 C 0.285 G 0.274 T 0.224 Background letter frequencies (from file dataset with add-one prior applied): A 0.218 C 0.285 G 0.274 T 0.224 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF HARCCAAT MEME-1 width = 8 sites = 77 llr = 584 E-value = 1.5e-025 ******************************************************************************** -------------------------------------------------------------------------------- Motif HARCCAAT MEME-1 Description -------------------------------------------------------------------------------- Simplified A 365::a7: pos.-specific C 31:aa::: probability G 134::::: matrix T 2:1:::3a bits 2.2 * * 2.0 * * 1.8 *** * 1.5 *** * Relative 1.3 ***** Entropy 1.1 ***** (10.9 bits) 0.9 * ***** 0.7 ******* 0.4 ******* 0.2 ******* 0.0 -------- Multilevel CAACCAAT consensus AGG T sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HARCCAAT MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr3:33482160-33482240 60 2.07e-05 CCCGACTAAA CAACCAAT CAAAATGTTC chr12:56211752-56211832 9 2.07e-05 CAGACCAC CAACCAAT GGGTGGTGGC chr19:55973115-55973195 67 2.07e-05 CCCTGCCTCT CAACCAAT CCGCAT chr5:32313272-32313352 70 2.07e-05 ATGTTTCCTC CAACCAAT CCA chr10:104261969-10426204 59 2.07e-05 ACAGCCAGAG CAACCAAT AGAGCGATCG chr16:30382175-30382255 3 2.99e-05 CT TAACCAAT AGGAATGGTA chr15:89631455-89631535 7 2.99e-05 CAAATG TAACCAAT TGCTGAGGAG chr17:61627663-61627743 49 2.99e-05 ACGGCCGCAA TAACCAAT GACAAGAAAG chr14:104181862-10418194 27 2.99e-05 ACTGACTAAC TAACCAAT CCAAAGTCTC chr19:6425215-6425295 17 4.11e-05 TCGTGGACAC AAGCCAAT GAATGCACGT chr1:87479122-87479202 47 6.51e-05 ctggcccagg aaaccatt ttttcctcct chr14:55779494-55779574 37 6.51e-05 ctggcccagg aaaccatt ttttcctcct chrX:154444562-154444642 10 6.51e-05 ACCTGAGCG CAGCCAAT CAGCACCTAG chr6:68832117-68832197 24 6.51e-05 ccagcctatg aaaccatt ttgtcctcct chr1:93708968-93709048 24 6.51e-05 cccacccatg aaaccatt ttttcctcct chr2:119502523-119502603 33 6.51e-05 ctagcccatg aaaccatt tgttcctcct chr7:154518248-154518328 31 6.51e-05 ccggcccatg aaaccatt ctttcctcct chr9:35072698-35072778 41 6.51e-05 CCGCAGATCA CAGCCAAT CAGGAAATTC chr5:37283511-37283591 28 6.51e-05 tgggaccatg aaaccatt ttttcctcct chr17:41397316-41397396 34 6.51e-05 acagcccatg aaaccatt ttttcctact chr19:36248876-36248956 48 6.51e-05 GCAGTCGTCC CAGCCAAT CCTGAAACAC chr22:47152133-47152213 44 6.51e-05 ctggcccctc aaaccatt ctttcctcct chr11:77566140-77566220 52 6.51e-05 ctgtcccaca aaaccatt atttcctcct chr1:109328064-109328144 39 6.51e-05 ctgacccacg aaaccatt ttttcctcct chr1:12282943-12283023 1 6.51e-05 . aaaccatt ttttcctcct chr9:90070478-90070558 54 6.51e-05 ctggcccata aaaccatt ctgtcctcct chr7:86834437-86834517 59 6.51e-05 ccagcccaca aaaccatt ttatcctcct chr10:1026633-1026713 9 6.51e-05 gacccgtg aaaccatt ctgccctcct chr1:227473630-227473710 32 6.51e-05 tggccccttg aaaccatt ctgtcctcct chr6:32146015-32146095 38 6.51e-05 TAGACCGTAT CAGCCAAT AGCCATTGTG chr6:119404342-119404422 35 6.51e-05 ccagcccacg aaaccatt ttttcctcct chr19:50180328-50180408 41 8.87e-05 ACGTATTCTC TAGCCAAT TACTAGACGG chr19:46498529-46498609 43 8.87e-05 TCTTCTTAGT TAGCCAAT TGGAAGTTTT chr19:18315100-18315180 33 8.87e-05 ACGGGCGAAG TAGCCAAT CAGAGATTGT chr2:97523833-97523913 65 1.09e-04 CTTAGCTCGA GAACCAAT TGCAACGG chr19:54663628-54663708 36 1.09e-04 TCACAGATCT GAACCAAT CATAAGTTGG chr19:45394320-45394400 30 1.09e-04 CTGCGAGTGA GAACCAAT ACAAAAGGAC chr19:1205570-1205650 29 1.35e-04 GGCCAAGCGC CGACCAAT CGCCGCTCGG chr9:139780750-139780830 3 1.35e-04 GC CGACCAAT CGGCGCACGC chr14:96001179-96001259 1 1.35e-04 . CGACCAAT AGTAAGGCAG chr2:62081714-62081794 70 1.58e-04 TTTCTTGACA TGACCAAT AAA chr1:6845266-6845346 63 1.58e-04 CGTTGATTCT TGACCAAT CCTTTCAGTC chr12:113658920-11365900 44 1.58e-04 TCCTGAAGTC TGACCAAT CAGAAGCACC chr7:33578999-33579079 69 1.74e-04 gactgcagtg cagccatt gtcc chr16:11254655-11254735 63 1.74e-04 gctggagttc cagccatt gcatccattt chr1:45140234-45140314 71 1.74e-04 TACTGACCCG CAGCCATT GG chr7:100825844-100825924 27 1.74e-04 CCAGTTCCAT CAGCCATT CAGAATTAAA chr17:46125544-46125624 35 1.74e-04 GAGGTACACT CAGCCATT GGGCCCTCTC chr3:195163915-195163995 6 2.00e-04 AACCC GAGCCAAT GAGCAGCGCG chr13:20532724-20532804 33 2.00e-04 ACGGCCGTCG GAGCCAAT GGGCGTGCCC chr11:59383423-59383503 17 2.35e-04 GTTCAGATAA AGGCCAAT CAGACTTTTG chr7:100184146-100184226 31 2.35e-04 ACTGTCAAGA AGGCCAAT TAGAGCCTCC chr19:54641269-54641349 6 2.35e-04 GCGGG AGGCCAAT CGAACGCCGC chr22:37172211-37172291 26 2.35e-04 GTCTCACAAA AATCCAAT GGGAGTAGAG chr6:137510163-137510243 26 2.77e-04 tgacttacac agaccatt cacaacatgc chr2:220094384-220094464 26 2.77e-04 GGAGACACAA CGGCCAAT TCTCGGCTTC chr1:117664452-117664532 32 2.77e-04 CGCCACTAAG CATCCAAT AAGTTTTGGA chr22:40440674-40440754 68 2.77e-04 ATCCTCCCTG CGGCCAAT GGAGT chr11:67798027-67798107 35 3.16e-04 GCAGCCTTGC TGGCCAAT CAGACCACAC chr14:21737706-21737786 7 3.16e-04 CAATGA TATCCAAT CACAATTAGC chr1:150601659-150601739 16 3.16e-04 GTAGGCCTAT TGGCCAAT CAGGAAGAGT chr1:61543722-61543802 39 3.16e-04 ACAAAAGCTT TATCCAAT CATAAGGAAG chr19:11457022-11457102 62 3.16e-04 CACGGGCTTT TATCCAAT TACGCCGCGG chr11:71823448-71823528 11 3.42e-04 GGCCTGGGTA GGACCAAT TAACTGAAAG chr4:52709128-52709208 20 3.42e-04 CAAGGCCCCA GGACCAAT CGTATTGGCC chr19:41284001-41284081 33 3.83e-04 CCTTCTCACG CCACCAAT CCGCGCCTCT chr9:128003812-128003892 19 3.95e-04 TTTCTAACGT TCACCAAT GGTAGATAAC chr3:88108232-88108312 6 3.95e-04 CGATT TCACCAAT AGTAGTGGAA chr19:14228668-14228748 41 4.51e-04 CGCGGACTCT CGGCCATT CACTCGCTCG chr11:68228033-68228113 46 5.05e-04 GCCGCTAGGC GATCCAAT AGGTAGTAGG chr1:113932898-113932978 61 5.05e-04 TGCCCGCCGG GGGCCAAT CCCTGGCGCG chr19:36193341-36193421 18 5.05e-04 ACGAGCCTTA GGGCCAAT CAGAAGCGAC chr9:37465776-37465856 44 5.77e-04 CCGCCTAAAT CCGCCAAT CACAACAACG chr1:38397514-38397594 73 5.77e-04 ATACCTGCCT CCGCCAAT chr19:10828452-10828532 15 6.23e-04 TGGTGGAACT TCGCCAAT GGGCAGAGCC chr16:22385998-22386078 30 6.23e-04 GCAGGGACTT CGTCCAAT CGCCTCTCTC chrX:49047657-49047737 26 8.30e-04 CCATCTTGAA GCACCATT CTTCTTTTCT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HARCCAAT MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr3:33482160-33482240 2.1e-05 59_[+1]_13 chr12:56211752-56211832 2.1e-05 8_[+1]_64 chr19:55973115-55973195 2.1e-05 66_[+1]_6 chr5:32313272-32313352 2.1e-05 69_[+1]_3 chr10:104261969-10426204 2.1e-05 58_[+1]_14 chr16:30382175-30382255 3e-05 2_[+1]_70 chr15:89631455-89631535 3e-05 6_[+1]_66 chr17:61627663-61627743 3e-05 48_[+1]_24 chr14:104181862-10418194 3e-05 26_[+1]_46 chr19:6425215-6425295 4.1e-05 16_[+1]_56 chr1:87479122-87479202 6.5e-05 46_[+1]_26 chr14:55779494-55779574 6.5e-05 36_[+1]_36 chrX:154444562-154444642 6.5e-05 9_[+1]_63 chr6:68832117-68832197 6.5e-05 23_[+1]_49 chr1:93708968-93709048 6.5e-05 23_[+1]_49 chr2:119502523-119502603 6.5e-05 32_[+1]_40 chr7:154518248-154518328 6.5e-05 30_[+1]_42 chr9:35072698-35072778 6.5e-05 40_[+1]_32 chr5:37283511-37283591 6.5e-05 27_[+1]_45 chr17:41397316-41397396 6.5e-05 33_[+1]_39 chr19:36248876-36248956 6.5e-05 47_[+1]_25 chr22:47152133-47152213 6.5e-05 43_[+1]_29 chr11:77566140-77566220 6.5e-05 51_[+1]_21 chr1:109328064-109328144 6.5e-05 38_[+1]_34 chr1:12282943-12283023 6.5e-05 [+1]_72 chr9:90070478-90070558 6.5e-05 53_[+1]_19 chr7:86834437-86834517 6.5e-05 58_[+1]_14 chr10:1026633-1026713 6.5e-05 8_[+1]_64 chr1:227473630-227473710 6.5e-05 31_[+1]_41 chr6:32146015-32146095 6.5e-05 37_[+1]_35 chr6:119404342-119404422 6.5e-05 34_[+1]_38 chr19:50180328-50180408 8.9e-05 40_[+1]_32 chr19:46498529-46498609 8.9e-05 42_[+1]_30 chr19:18315100-18315180 8.9e-05 32_[+1]_40 chr2:97523833-97523913 0.00011 64_[+1]_8 chr19:54663628-54663708 0.00011 35_[+1]_37 chr19:45394320-45394400 0.00011 29_[+1]_43 chr19:1205570-1205650 0.00014 28_[+1]_44 chr9:139780750-139780830 0.00014 2_[+1]_70 chr14:96001179-96001259 0.00014 [+1]_72 chr2:62081714-62081794 0.00016 69_[+1]_3 chr1:6845266-6845346 0.00016 62_[+1]_10 chr12:113658920-11365900 0.00016 43_[+1]_29 chr7:33578999-33579079 0.00017 68_[+1]_4 chr16:11254655-11254735 0.00017 62_[+1]_10 chr1:45140234-45140314 0.00017 70_[+1]_2 chr7:100825844-100825924 0.00017 26_[+1]_46 chr17:46125544-46125624 0.00017 34_[+1]_38 chr3:195163915-195163995 0.0002 5_[+1]_67 chr13:20532724-20532804 0.0002 32_[+1]_40 chr11:59383423-59383503 0.00023 16_[+1]_56 chr7:100184146-100184226 0.00023 30_[+1]_42 chr19:54641269-54641349 0.00023 5_[+1]_67 chr22:37172211-37172291 0.00023 25_[+1]_47 chr6:137510163-137510243 0.00028 25_[+1]_47 chr2:220094384-220094464 0.00028 25_[+1]_47 chr1:117664452-117664532 0.00028 31_[+1]_41 chr22:40440674-40440754 0.00028 67_[+1]_5 chr11:67798027-67798107 0.00032 34_[+1]_38 chr14:21737706-21737786 0.00032 6_[+1]_66 chr1:150601659-150601739 0.00032 15_[+1]_57 chr1:61543722-61543802 0.00032 38_[+1]_34 chr19:11457022-11457102 0.00032 61_[+1]_11 chr11:71823448-71823528 0.00034 10_[+1]_62 chr4:52709128-52709208 0.00034 19_[+1]_53 chr19:41284001-41284081 0.00038 32_[+1]_40 chr9:128003812-128003892 0.0004 18_[+1]_54 chr3:88108232-88108312 0.0004 5_[+1]_67 chr19:14228668-14228748 0.00045 40_[+1]_32 chr11:68228033-68228113 0.0005 45_[+1]_27 chr1:113932898-113932978 0.0005 60_[+1]_12 chr19:36193341-36193421 0.0005 17_[+1]_55 chr9:37465776-37465856 0.00058 43_[+1]_29 chr1:38397514-38397594 0.00058 72_[+1] chr19:10828452-10828532 0.00062 14_[+1]_58 chr16:22385998-22386078 0.00062 29_[+1]_43 chrX:49047657-49047737 0.00083 25_[+1]_47 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HARCCAAT MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF HARCCAAT width=8 seqs=77 chr3:33482160-33482240 ( 60) CAACCAAT 1 chr12:56211752-56211832 ( 9) CAACCAAT 1 chr19:55973115-55973195 ( 67) CAACCAAT 1 chr5:32313272-32313352 ( 70) CAACCAAT 1 chr10:104261969-10426204 ( 59) CAACCAAT 1 chr16:30382175-30382255 ( 3) TAACCAAT 1 chr15:89631455-89631535 ( 7) TAACCAAT 1 chr17:61627663-61627743 ( 49) TAACCAAT 1 chr14:104181862-10418194 ( 27) TAACCAAT 1 chr19:6425215-6425295 ( 17) AAGCCAAT 1 chr1:87479122-87479202 ( 47) AAACCATT 1 chr14:55779494-55779574 ( 37) AAACCATT 1 chrX:154444562-154444642 ( 10) CAGCCAAT 1 chr6:68832117-68832197 ( 24) AAACCATT 1 chr1:93708968-93709048 ( 24) AAACCATT 1 chr2:119502523-119502603 ( 33) AAACCATT 1 chr7:154518248-154518328 ( 31) AAACCATT 1 chr9:35072698-35072778 ( 41) CAGCCAAT 1 chr5:37283511-37283591 ( 28) AAACCATT 1 chr17:41397316-41397396 ( 34) AAACCATT 1 chr19:36248876-36248956 ( 48) CAGCCAAT 1 chr22:47152133-47152213 ( 44) AAACCATT 1 chr11:77566140-77566220 ( 52) AAACCATT 1 chr1:109328064-109328144 ( 39) AAACCATT 1 chr1:12282943-12283023 ( 1) AAACCATT 1 chr9:90070478-90070558 ( 54) AAACCATT 1 chr7:86834437-86834517 ( 59) AAACCATT 1 chr10:1026633-1026713 ( 9) AAACCATT 1 chr1:227473630-227473710 ( 32) AAACCATT 1 chr6:32146015-32146095 ( 38) CAGCCAAT 1 chr6:119404342-119404422 ( 35) AAACCATT 1 chr19:50180328-50180408 ( 41) TAGCCAAT 1 chr19:46498529-46498609 ( 43) TAGCCAAT 1 chr19:18315100-18315180 ( 33) TAGCCAAT 1 chr2:97523833-97523913 ( 65) GAACCAAT 1 chr19:54663628-54663708 ( 36) GAACCAAT 1 chr19:45394320-45394400 ( 30) GAACCAAT 1 chr19:1205570-1205650 ( 29) CGACCAAT 1 chr9:139780750-139780830 ( 3) CGACCAAT 1 chr14:96001179-96001259 ( 1) CGACCAAT 1 chr2:62081714-62081794 ( 70) TGACCAAT 1 chr1:6845266-6845346 ( 63) TGACCAAT 1 chr12:113658920-11365900 ( 44) TGACCAAT 1 chr7:33578999-33579079 ( 69) CAGCCATT 1 chr16:11254655-11254735 ( 63) CAGCCATT 1 chr1:45140234-45140314 ( 71) CAGCCATT 1 chr7:100825844-100825924 ( 27) CAGCCATT 1 chr17:46125544-46125624 ( 35) CAGCCATT 1 chr3:195163915-195163995 ( 6) GAGCCAAT 1 chr13:20532724-20532804 ( 33) GAGCCAAT 1 chr11:59383423-59383503 ( 17) AGGCCAAT 1 chr7:100184146-100184226 ( 31) AGGCCAAT 1 chr19:54641269-54641349 ( 6) AGGCCAAT 1 chr22:37172211-37172291 ( 26) AATCCAAT 1 chr6:137510163-137510243 ( 26) AGACCATT 1 chr2:220094384-220094464 ( 26) CGGCCAAT 1 chr1:117664452-117664532 ( 32) CATCCAAT 1 chr22:40440674-40440754 ( 68) CGGCCAAT 1 chr11:67798027-67798107 ( 35) TGGCCAAT 1 chr14:21737706-21737786 ( 7) TATCCAAT 1 chr1:150601659-150601739 ( 16) TGGCCAAT 1 chr1:61543722-61543802 ( 39) TATCCAAT 1 chr19:11457022-11457102 ( 62) TATCCAAT 1 chr11:71823448-71823528 ( 11) GGACCAAT 1 chr4:52709128-52709208 ( 20) GGACCAAT 1 chr19:41284001-41284081 ( 33) CCACCAAT 1 chr9:128003812-128003892 ( 19) TCACCAAT 1 chr3:88108232-88108312 ( 6) TCACCAAT 1 chr19:14228668-14228748 ( 41) CGGCCATT 1 chr11:68228033-68228113 ( 46) GATCCAAT 1 chr1:113932898-113932978 ( 61) GGGCCAAT 1 chr19:36193341-36193421 ( 18) GGGCCAAT 1 chr9:37465776-37465856 ( 44) CCGCCAAT 1 chr1:38397514-38397594 ( 73) CCGCCAAT 1 chr19:10828452-10828532 ( 15) TCGCCAAT 1 chr16:22385998-22386078 ( 30) CGTCCAAT 1 chrX:49047657-49047737 ( 26) GCACCATT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HARCCAAT MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.33575 E= 1.5e-025 45 19 -94 6 158 -165 -8 -1291 132 -1291 41 -130 -1291 181 -1291 -1291 -1291 181 -1291 -1291 220 -1291 -1291 -1291 163 -1291 -1291 54 -1291 -1291 -1291 216 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HARCCAAT MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 77 E= 1.5e-025 0.298701 0.324675 0.142857 0.233766 0.649351 0.090909 0.259740 0.000000 0.545455 0.000000 0.363636 0.090909 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.675325 0.000000 0.000000 0.324675 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HARCCAAT MEME-1 regular expression -------------------------------------------------------------------------------- [CAT][AG][AG]CCA[AT]T -------------------------------------------------------------------------------- Time 4.96 secs. ******************************************************************************** ******************************************************************************** MOTIF NATTGGYT MEME-2 width = 8 sites = 67 llr = 520 E-value = 3.0e-021 ******************************************************************************** -------------------------------------------------------------------------------- Motif NATTGGYT MEME-2 Description -------------------------------------------------------------------------------- Simplified A 2a3::::: pos.-specific C 3:::::53 probability G 3:::aa:1 matrix T 2:7a::56 bits 2.2 * * 2.0 * *** 1.8 * *** 1.5 * *** Relative 1.3 ***** Entropy 1.1 ****** (11.2 bits) 0.9 ****** 0.7 ******* 0.4 ******* 0.2 ******* 0.0 -------- Multilevel GATTGGTT consensus C A CC sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif NATTGGYT MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:12847762-12847842 8 1.13e-05 CGTCTAT GATTGGTT TGCGGCAAGA chr12:6961103-6961183 13 1.13e-05 GGAGGAGTGG GATTGGTT CTTTCAACCA chr11:59383423-59383503 2 1.13e-05 T GATTGGTT CAGATAAAGG chr16:77224639-77224719 51 2.05e-05 CAACGCACAG TATTGGTT AGGATTTGGC chr22:38054418-38054498 22 2.05e-05 TGTAGATTCT TATTGGTT AAGAAGAGCG chr9:135905900-135905980 69 2.05e-05 TCTAGTTCTT TATTGGTT AAAA chr9:128003812-128003892 58 3.23e-05 CCGCTGGTCC CATTGGTT CAGCAGCTGT chr19:42773325-42773405 43 5.56e-05 TGTGATCGCT GATTGGCT GGCTGCTCCA chr14:73925421-73925501 37 5.56e-05 CTTTAGTTGT AATTGGTT GAGGGTTGGG chr2:73460461-73460541 70 5.56e-05 GCCGGGGGCT GATTGGCT TAA chr7:2884050-2884130 4 5.56e-05 TTC GATTGGCT CATCTCGCCA chr2:74685336-74685416 34 6.74e-05 CTGTTGTCTG TATTGGCT ATTGCCGCTG chr6:80247190-80247270 36 6.74e-05 CGGCCCTTTT TATTGGCT TCAGTGGAAC chrX:49125725-49125805 13 6.74e-05 TTAGCCTTCG TATTGGCT AGCTCCACCT chr1:244211631-244211711 24 8.23e-05 TCGCCACCCC CATTGGCT GGGCCCCCTT chr12:49504660-49504740 56 8.23e-05 GGGAGGAACT CATTGGCT CCTGGAGAGC chr19:47551918-47551998 42 8.23e-05 ATGGCTTACC CATTGGCT ATGCGCTCGC chr17:8534188-8534268 64 8.23e-05 GAATGACGCT CATTGGCT CCCGCTCCC chr13:20437846-20437926 43 8.23e-05 TGGGCACGCC CATTGGCT CCGACGGCCG chr19:3971230-3971310 57 8.23e-05 TCCCTGATTT CATTGGCT GCAGTCGACG chr5:171847690-171847770 12 8.23e-05 CCGGCAAGCC CATTGGCT GCGACATTTC chr11:107798882-10779896 15 8.23e-05 TCTCACTTTT CATTGGCT GACCCTCCCG chr10:104261969-10426204 34 8.23e-05 GAGGCGGTAT CATTGGCT AAGATGGACA chr11:62521651-62521731 6 9.37e-05 GCTTT AATTGGCT TAAGATTGCC chr19:18303793-18303873 20 1.19e-04 TCTTTTTTCC GATTGGTC CGTGAAGCTC chr20:44486063-44486143 28 1.19e-04 TCTAGGTTAT GATTGGTC AGGACTCCTG chr17:26368560-26368640 2 1.19e-04 T GATTGGTC TTTCTATCTG chr17:47866526-47866606 71 1.19e-04 CTCCTCTCCT GATTGGTC GA chr9:96891020-96891100 43 1.19e-04 taggaggact gaatggtt ttgtgggcca chr3:193432496-193432576 18 1.19e-04 taggaggaaa gaatggtt tcctgggcca chr1:151334991-151335071 20 1.19e-04 taggaggact gaatggtt ttgtgggcca chr16:90121119-90121199 37 1.19e-04 taggagggct gaatggtt tgggccagcc chr6:147286393-147286473 52 1.19e-04 taggaggaca gaatggtt ttgtgggcca chr22:19304389-19304469 64 1.40e-04 ctgttctacc tattggtc tctccagtc chr17:17875940-17876020 32 1.40e-04 TTCCTCTGTA TATTGGTC AATCTAAAGG chr2:71454302-71454382 44 1.40e-04 ATGTGGTTTT TATTGGTC TAAATGTGAA chr4:175204380-175204460 46 1.66e-04 TTCGCACTGT CATTGGTC GCAAACTCTT chr9:130829724-130829804 67 1.66e-04 TTCGCCTGAT CATTGGTC TAAAAT chr9:130159274-130159354 20 1.66e-04 TCTATGCTCC CATTGGTC TGCTTTAATG chr19:58960381-58960461 28 2.19e-04 taggaggaaa aaatggtt tcgtgggctc chr19:7822394-7822474 49 2.19e-04 taggaggaaa aaatggtt tcgtgggctg chr19:42580147-42580227 62 2.19e-04 CATGAACGTC GATTGGCC GAACGGCAGG chr19:48972389-48972469 41 2.19e-04 CCTGCACTCC GATTGGCC CCGCGGGCCG chr7:153273329-153273409 50 2.19e-04 taggaggaaa aaatggtt tcatgggctg chr17:79196833-79196913 2 2.19e-04 G GATTGGCC CTTCACGCTC chrX:107062268-107062348 57 2.19e-04 taggaggact aaatggtt tcctgggcca chr16:639263-639343 66 2.19e-04 ATCGAGCGCC GATTGGCC GCACCGC chr11:67275739-67275819 45 2.19e-04 AACCGCCGCC GATTGGCC TCCGCCTTCC chr1:205124940-205125020 47 2.19e-04 taggagggaa aaatggtt ctgtgggctg chr1:45723868-45723948 35 2.19e-04 taggaggaca aaatggtt tgtgggccag chr3:33007192-33007272 45 2.19e-04 taggagggaa aaatggtt tcctgggcca chr2:62504974-62505054 36 2.19e-04 taggaggact aaatggtt ctgagggcca chr21:43780571-43780651 41 2.45e-04 CATTATTACA TAATGGCT GCCTGCAACA chr12:56367587-56367667 34 2.45e-04 GCTTGCTCTT TAATGGCT CCTTACCTCG chr19:46087711-46087791 44 2.45e-04 AACCCCCCAC TATTGGCC ACTGGACTTT chr4:52709128-52709208 30 2.45e-04 GGACCAATCG TATTGGCC AGTGGGGGGC chr5:159546585-159546665 58 2.79e-04 AGGAACTTCT CATTGGCC AGATGTGTTG chr17:39943145-39943225 7 2.79e-04 GCTTGC CATTGGCC CCGGGGACTG chr4:2433878-2433958 30 3.04e-04 catagtcact aaatggct gccctacctc chr7:146207333-146207413 8 3.04e-04 ttacatt aaatggct acataaatgt chr2:88927169-88927249 40 3.18e-04 CTTTTTACCT GATTGGTG CGCTCATCAG chr19:1633551-1633631 5 3.43e-04 GGAG TATTGGTG TTTAATTGCT chr2:65283343-65283423 66 3.43e-04 AGCGTCCACG TATTGGTG GAGCCGC chr22:29999342-29999422 29 3.69e-04 TGAAACTTTC CATTGGTG GAGTCACCCC chr10:5932022-5932102 29 4.12e-04 TGCGCATTTC GATTGGCG TTAGTGGCCG chr1:25757194-25757274 13 4.12e-04 ACACTATAAT GATTGGCG CATTCTTCCG chr19:18315100-18315180 69 5.73e-04 TCCTCTTGTC CAATGGTG GCAT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif NATTGGYT MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:12847762-12847842 1.1e-05 7_[+2]_65 chr12:6961103-6961183 1.1e-05 12_[+2]_60 chr11:59383423-59383503 1.1e-05 1_[+2]_71 chr16:77224639-77224719 2.1e-05 50_[+2]_22 chr22:38054418-38054498 2.1e-05 21_[+2]_51 chr9:135905900-135905980 2.1e-05 68_[+2]_4 chr9:128003812-128003892 3.2e-05 57_[+2]_15 chr19:42773325-42773405 5.6e-05 42_[+2]_30 chr14:73925421-73925501 5.6e-05 36_[+2]_36 chr2:73460461-73460541 5.6e-05 69_[+2]_3 chr7:2884050-2884130 5.6e-05 3_[+2]_69 chr2:74685336-74685416 6.7e-05 33_[+2]_39 chr6:80247190-80247270 6.7e-05 35_[+2]_37 chrX:49125725-49125805 6.7e-05 12_[+2]_60 chr1:244211631-244211711 8.2e-05 23_[+2]_49 chr12:49504660-49504740 8.2e-05 55_[+2]_17 chr19:47551918-47551998 8.2e-05 41_[+2]_31 chr17:8534188-8534268 8.2e-05 63_[+2]_9 chr13:20437846-20437926 8.2e-05 42_[+2]_30 chr19:3971230-3971310 8.2e-05 56_[+2]_16 chr5:171847690-171847770 8.2e-05 11_[+2]_61 chr11:107798882-10779896 8.2e-05 14_[+2]_58 chr10:104261969-10426204 8.2e-05 33_[+2]_39 chr11:62521651-62521731 9.4e-05 5_[+2]_67 chr19:18303793-18303873 0.00012 19_[+2]_53 chr20:44486063-44486143 0.00012 27_[+2]_45 chr17:26368560-26368640 0.00012 1_[+2]_71 chr17:47866526-47866606 0.00012 70_[+2]_2 chr9:96891020-96891100 0.00012 42_[+2]_30 chr3:193432496-193432576 0.00012 17_[+2]_55 chr1:151334991-151335071 0.00012 19_[+2]_53 chr16:90121119-90121199 0.00012 36_[+2]_36 chr6:147286393-147286473 0.00012 51_[+2]_21 chr22:19304389-19304469 0.00014 63_[+2]_9 chr17:17875940-17876020 0.00014 31_[+2]_41 chr2:71454302-71454382 0.00014 43_[+2]_29 chr4:175204380-175204460 0.00017 45_[+2]_27 chr9:130829724-130829804 0.00017 66_[+2]_6 chr9:130159274-130159354 0.00017 19_[+2]_53 chr19:58960381-58960461 0.00022 27_[+2]_45 chr19:7822394-7822474 0.00022 48_[+2]_24 chr19:42580147-42580227 0.00022 61_[+2]_11 chr19:48972389-48972469 0.00022 40_[+2]_32 chr7:153273329-153273409 0.00022 49_[+2]_23 chr17:79196833-79196913 0.00022 1_[+2]_71 chrX:107062268-107062348 0.00022 56_[+2]_16 chr16:639263-639343 0.00022 65_[+2]_7 chr11:67275739-67275819 0.00022 44_[+2]_28 chr1:205124940-205125020 0.00022 46_[+2]_26 chr1:45723868-45723948 0.00022 34_[+2]_38 chr3:33007192-33007272 0.00022 44_[+2]_28 chr2:62504974-62505054 0.00022 35_[+2]_37 chr21:43780571-43780651 0.00024 40_[+2]_32 chr12:56367587-56367667 0.00024 33_[+2]_39 chr19:46087711-46087791 0.00024 43_[+2]_29 chr4:52709128-52709208 0.00024 29_[+2]_43 chr5:159546585-159546665 0.00028 57_[+2]_15 chr17:39943145-39943225 0.00028 6_[+2]_66 chr4:2433878-2433958 0.0003 29_[+2]_43 chr7:146207333-146207413 0.0003 7_[+2]_65 chr2:88927169-88927249 0.00032 39_[+2]_33 chr19:1633551-1633631 0.00034 4_[+2]_68 chr2:65283343-65283423 0.00034 65_[+2]_7 chr22:29999342-29999422 0.00037 28_[+2]_44 chr10:5932022-5932102 0.00041 28_[+2]_44 chr1:25757194-25757274 0.00041 12_[+2]_60 chr19:18315100-18315180 0.00057 68_[+2]_4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif NATTGGYT MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF NATTGGYT width=8 seqs=67 chr19:12847762-12847842 ( 8) GATTGGTT 1 chr12:6961103-6961183 ( 13) GATTGGTT 1 chr11:59383423-59383503 ( 2) GATTGGTT 1 chr16:77224639-77224719 ( 51) TATTGGTT 1 chr22:38054418-38054498 ( 22) TATTGGTT 1 chr9:135905900-135905980 ( 69) TATTGGTT 1 chr9:128003812-128003892 ( 58) CATTGGTT 1 chr19:42773325-42773405 ( 43) GATTGGCT 1 chr14:73925421-73925501 ( 37) AATTGGTT 1 chr2:73460461-73460541 ( 70) GATTGGCT 1 chr7:2884050-2884130 ( 4) GATTGGCT 1 chr2:74685336-74685416 ( 34) TATTGGCT 1 chr6:80247190-80247270 ( 36) TATTGGCT 1 chrX:49125725-49125805 ( 13) TATTGGCT 1 chr1:244211631-244211711 ( 24) CATTGGCT 1 chr12:49504660-49504740 ( 56) CATTGGCT 1 chr19:47551918-47551998 ( 42) CATTGGCT 1 chr17:8534188-8534268 ( 64) CATTGGCT 1 chr13:20437846-20437926 ( 43) CATTGGCT 1 chr19:3971230-3971310 ( 57) CATTGGCT 1 chr5:171847690-171847770 ( 12) CATTGGCT 1 chr11:107798882-10779896 ( 15) CATTGGCT 1 chr10:104261969-10426204 ( 34) CATTGGCT 1 chr11:62521651-62521731 ( 6) AATTGGCT 1 chr19:18303793-18303873 ( 20) GATTGGTC 1 chr20:44486063-44486143 ( 28) GATTGGTC 1 chr17:26368560-26368640 ( 2) GATTGGTC 1 chr17:47866526-47866606 ( 71) GATTGGTC 1 chr9:96891020-96891100 ( 43) GAATGGTT 1 chr3:193432496-193432576 ( 18) GAATGGTT 1 chr1:151334991-151335071 ( 20) GAATGGTT 1 chr16:90121119-90121199 ( 37) GAATGGTT 1 chr6:147286393-147286473 ( 52) GAATGGTT 1 chr22:19304389-19304469 ( 64) TATTGGTC 1 chr17:17875940-17876020 ( 32) TATTGGTC 1 chr2:71454302-71454382 ( 44) TATTGGTC 1 chr4:175204380-175204460 ( 46) CATTGGTC 1 chr9:130829724-130829804 ( 67) CATTGGTC 1 chr9:130159274-130159354 ( 20) CATTGGTC 1 chr19:58960381-58960461 ( 28) AAATGGTT 1 chr19:7822394-7822474 ( 49) AAATGGTT 1 chr19:42580147-42580227 ( 62) GATTGGCC 1 chr19:48972389-48972469 ( 41) GATTGGCC 1 chr7:153273329-153273409 ( 50) AAATGGTT 1 chr17:79196833-79196913 ( 2) GATTGGCC 1 chrX:107062268-107062348 ( 57) AAATGGTT 1 chr16:639263-639343 ( 66) GATTGGCC 1 chr11:67275739-67275819 ( 45) GATTGGCC 1 chr1:205124940-205125020 ( 47) AAATGGTT 1 chr1:45723868-45723948 ( 35) AAATGGTT 1 chr3:33007192-33007272 ( 45) AAATGGTT 1 chr2:62504974-62505054 ( 36) AAATGGTT 1 chr21:43780571-43780651 ( 41) TAATGGCT 1 chr12:56367587-56367667 ( 34) TAATGGCT 1 chr19:46087711-46087791 ( 44) TATTGGCC 1 chr4:52709128-52709208 ( 30) TATTGGCC 1 chr5:159546585-159546665 ( 58) CATTGGCC 1 chr17:39943145-39943225 ( 7) CATTGGCC 1 chr4:2433878-2433958 ( 30) AAATGGCT 1 chr7:146207333-146207413 ( 8) AAATGGCT 1 chr2:88927169-88927249 ( 40) GATTGGTG 1 chr19:1633551-1633631 ( 5) TATTGGTG 1 chr2:65283343-65283423 ( 66) TATTGGTG 1 chr22:29999342-29999422 ( 29) CATTGGTG 1 chr10:5932022-5932102 ( 29) GATTGGCG 1 chr1:25757194-25757274 ( 13) GATTGGCG 1 chr19:18315100-18315180 ( 69) CAATGGTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif NATTGGYT MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.84661 E= 3.0e-021 -28 -17 33 0 220 -1271 -1271 -1271 30 -1271 -1271 171 -1271 -1271 -1271 216 -1271 -1271 187 -1271 -1271 -1271 187 -1271 -1271 70 -1271 127 -1271 -1 -139 145 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif NATTGGYT MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 67 E= 3.0e-021 0.179104 0.253731 0.343284 0.223881 1.000000 0.000000 0.000000 0.000000 0.268657 0.000000 0.000000 0.731343 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.462687 0.000000 0.537313 0.000000 0.283582 0.104478 0.611940 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif NATTGGYT MEME-2 regular expression -------------------------------------------------------------------------------- [GCT]A[TA]TGG[TC][TC] -------------------------------------------------------------------------------- Time 8.61 secs. ******************************************************************************** ******************************************************************************** MOTIF TCCTCCTA MEME-3 width = 8 sites = 28 llr = 269 E-value = 2.7e-013 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCCTCCTA MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::::119 pos.-specific C 1aa:a9:: probability G :::::::1 matrix T 9::a::9: bits 2.2 * 2.0 * 1.8 ** ** ** 1.5 ***** ** Relative 1.3 ******** Entropy 1.1 ******** (13.9 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TCCTCCTA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCTCCTA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:87479122-87479202 58 1.62e-05 aaccattttt tcctccta ggcctctggg chr6:68832117-68832197 35 1.62e-05 aaccattttg tcctccta ggcctctggg chr1:93708968-93709048 35 1.62e-05 aaccattttt tcctccta ggcctccagg chr2:119502523-119502603 44 1.62e-05 aaccatttgt tcctccta gacctgcagg chr6:140948277-140948357 50 1.62e-05 taacattttt tcctccta ggcctccagg chr7:154518248-154518328 42 1.62e-05 aaccattctt tcctccta ggcctccagg chr5:37283511-37283591 39 1.62e-05 aaccattttt tcctccta ggcctctggg chr2:39587011-39587091 30 1.62e-05 taccattttt tcctccta agcctccagg chr22:47152133-47152213 55 1.62e-05 aaccattctt tcctccta ggcctctggg chr11:77566140-77566220 63 1.62e-05 aaccattatt tcctccta ggcctccagg chr1:12282943-12283023 12 1.62e-05 aaccattttt tcctccta ggcctccagg chr16:16075435-16075515 69 1.62e-05 aatcattttt tcctccta gacc chr9:90070478-90070558 65 1.62e-05 aaccattctg tcctccta ggcctcca chr7:86834437-86834517 70 1.62e-05 aaccatttta tcctccta ggc chr1:227473630-227473710 43 1.62e-05 aaccattctg tcctccta agcctctgag chr6:119404342-119404422 46 1.62e-05 aaccattttt tcctccta ggcctctggg chr16:11254655-11254735 32 2.85e-05 gtgtgattca tcctcata gctcagggca chr19:15529873-15529953 47 2.85e-05 TCTCTATGCC TCCTCATA TCAGTGGCTG chr17:80325839-80325919 46 2.85e-05 ctccccagct tcctcata ggctgagtac chr7:150725381-150725461 62 4.43e-05 TGACAACATA TCCTCCAA TCACAGCTTG chr12:56211752-56211832 41 4.43e-05 CTGATTCTGT TCCTCCAA TAGGAAAGGG chr1:38397514-38397594 31 4.43e-05 TGGCCGGGCC TCCTCCAA TCCCCACCGT chr14:55779494-55779574 48 6.46e-05 aaccattttt tcctcctg ggcctccagg chr10:58130656-58130736 47 6.46e-05 tcactaaaga tcctcctg tattcacccc chr13:41722989-41723069 41 6.46e-05 ctaaaaaaaa tcctcctg ttccacctat chr1:205124940-205125020 12 8.51e-05 taacagcagc ccctccta tgacaggcct chr10:1026633-1026713 20 8.51e-05 aaccattctg ccctccta ggcctctggg chr16:90121119-90121199 2 9.79e-05 c tcttccta tcacaggcct -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCTCCTA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:87479122-87479202 1.6e-05 57_[+3]_15 chr6:68832117-68832197 1.6e-05 34_[+3]_38 chr1:93708968-93709048 1.6e-05 34_[+3]_38 chr2:119502523-119502603 1.6e-05 43_[+3]_29 chr6:140948277-140948357 1.6e-05 49_[+3]_23 chr7:154518248-154518328 1.6e-05 41_[+3]_31 chr5:37283511-37283591 1.6e-05 38_[+3]_34 chr2:39587011-39587091 1.6e-05 29_[+3]_43 chr22:47152133-47152213 1.6e-05 54_[+3]_18 chr11:77566140-77566220 1.6e-05 62_[+3]_10 chr1:12282943-12283023 1.6e-05 11_[+3]_61 chr16:16075435-16075515 1.6e-05 68_[+3]_4 chr9:90070478-90070558 1.6e-05 64_[+3]_8 chr7:86834437-86834517 1.6e-05 69_[+3]_3 chr1:227473630-227473710 1.6e-05 42_[+3]_30 chr6:119404342-119404422 1.6e-05 45_[+3]_27 chr16:11254655-11254735 2.9e-05 31_[+3]_41 chr19:15529873-15529953 2.9e-05 46_[+3]_26 chr17:80325839-80325919 2.9e-05 45_[+3]_27 chr7:150725381-150725461 4.4e-05 61_[+3]_11 chr12:56211752-56211832 4.4e-05 40_[+3]_32 chr1:38397514-38397594 4.4e-05 30_[+3]_42 chr14:55779494-55779574 6.5e-05 47_[+3]_25 chr10:58130656-58130736 6.5e-05 46_[+3]_26 chr13:41722989-41723069 6.5e-05 40_[+3]_32 chr1:205124940-205125020 8.5e-05 11_[+3]_61 chr10:1026633-1026713 8.5e-05 19_[+3]_53 chr16:90121119-90121199 9.8e-05 1_[+3]_71 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCTCCTA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCCTCCTA width=8 seqs=28 chr1:87479122-87479202 ( 58) TCCTCCTA 1 chr6:68832117-68832197 ( 35) TCCTCCTA 1 chr1:93708968-93709048 ( 35) TCCTCCTA 1 chr2:119502523-119502603 ( 44) TCCTCCTA 1 chr6:140948277-140948357 ( 50) TCCTCCTA 1 chr7:154518248-154518328 ( 42) TCCTCCTA 1 chr5:37283511-37283591 ( 39) TCCTCCTA 1 chr2:39587011-39587091 ( 30) TCCTCCTA 1 chr22:47152133-47152213 ( 55) TCCTCCTA 1 chr11:77566140-77566220 ( 63) TCCTCCTA 1 chr1:12282943-12283023 ( 12) TCCTCCTA 1 chr16:16075435-16075515 ( 69) TCCTCCTA 1 chr9:90070478-90070558 ( 65) TCCTCCTA 1 chr7:86834437-86834517 ( 70) TCCTCCTA 1 chr1:227473630-227473710 ( 43) TCCTCCTA 1 chr6:119404342-119404422 ( 46) TCCTCCTA 1 chr16:11254655-11254735 ( 32) TCCTCATA 1 chr19:15529873-15529953 ( 47) TCCTCATA 1 chr17:80325839-80325919 ( 46) TCCTCATA 1 chr7:150725381-150725461 ( 62) TCCTCCAA 1 chr12:56211752-56211832 ( 41) TCCTCCAA 1 chr1:38397514-38397594 ( 31) TCCTCCAA 1 chr14:55779494-55779574 ( 48) TCCTCCTG 1 chr10:58130656-58130736 ( 47) TCCTCCTG 1 chr13:41722989-41723069 ( 41) TCCTCCTG 1 chr1:205124940-205125020 ( 12) CCCTCCTA 1 chr10:1026633-1026713 ( 20) CCCTCCTA 1 chr16:90121119-90121199 ( 2) TCTTCCTA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCTCCTA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.95252 E= 2.7e-013 -1145 -199 -1145 205 -1145 181 -1145 -1145 -1145 176 -1145 -264 -1145 -1145 -1145 216 -1145 181 -1145 -1145 -102 165 -1145 -1145 -102 -1145 -1145 200 203 -1145 -135 -1145 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCTCCTA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 28 E= 2.7e-013 0.000000 0.071429 0.000000 0.928571 0.000000 1.000000 0.000000 0.000000 0.000000 0.964286 0.000000 0.035714 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.107143 0.892857 0.000000 0.000000 0.107143 0.000000 0.000000 0.892857 0.892857 0.000000 0.107143 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCTCCTA MEME-3 regular expression -------------------------------------------------------------------------------- TCCTCCTA -------------------------------------------------------------------------------- Time 12.16 secs. ******************************************************************************** ******************************************************************************** MOTIF KRGGMGGR MEME-4 width = 8 sites = 69 llr = 512 E-value = 3.4e-012 ******************************************************************************** -------------------------------------------------------------------------------- Motif KRGGMGGR MEME-4 Description -------------------------------------------------------------------------------- Simplified A 15::4::3 pos.-specific C ::::4::: probability G 35aa:aa7 matrix T 5:::1::: bits 2.2 2.0 ** * 1.8 ** ** 1.5 ** ** Relative 1.3 ** ** Entropy 1.1 *** *** (10.7 bits) 0.9 *** *** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TGGGCGGG consensus GA A A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KRGGMGGR MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:205124940-205125020 37 1.64e-05 cctggaggtc taggaggg aaaaatggtt chr3:33007192-33007272 35 1.64e-05 cctggaggcc taggaggg aaaaatggtt chr16:90121119-90121199 27 1.64e-05 cctggaggct taggaggg ctgaatggtt chr6:68832117-68832197 60 5.86e-05 gggcctataa tgggaggg gctgccatga chr7:154518248-154518328 67 5.86e-05 aggcctgtga tgggaggg gctgcc chr17:41397316-41397396 70 5.86e-05 aagcctgtga tgggaggg tct chr2:39587011-39587091 55 5.86e-05 agggctgtga tgggaggg gttgctgcaa chr19:42901154-42901234 51 5.86e-05 CTTTGCCTGG TAGGCGGG GCCCACAGCC chr10:1026633-1026713 45 5.86e-05 gggcctatga tgggaggg gctcctggga chr6:119404342-119404422 71 5.86e-05 gggcctgtga tgggaggg gc chr19:58960381-58960461 18 9.87e-05 cccagaggcc taggagga aaaaatggtt chr12:49504660-49504740 27 9.87e-05 ACACAAGGGA TGGGCGGG TTCCTTCCAG chr19:7822394-7822474 39 9.87e-05 cctggaggcc taggagga aaaaatggtt chr19:11485260-11485340 43 9.87e-05 GGCCACGGCT TGGGCGGG ACTAAGGCTG chr1:173439901-173439981 39 9.87e-05 cctgggggcc taggagga aaaaacggtt chr3:128578539-128578619 25 9.87e-05 aagggtgaaa taggagga ttttattcag chr7:153273329-153273409 40 9.87e-05 cctggaggcc taggagga aaaaatggtt chr4:25225518-25225598 32 9.87e-05 gggggtgaga taggagga tttattgagt chrX:107062268-107062348 47 9.87e-05 cccagaggcc taggagga ctaaatggtt chr19:45394320-45394400 61 9.87e-05 TCAGGGAAAG TGGGCGGG ACTTTATGCA chr19:14228668-14228748 71 9.87e-05 AGGCCGCAGC TGGGCGGG CA chr13:91304433-91304513 26 9.87e-05 cctgggggtt taggagga aaaaatgatt chr1:45723868-45723948 25 9.87e-05 cctggaggtc taggagga caaaatggtt chr9:96891020-96891100 33 9.87e-05 ctgggaggcc taggagga ctgaatggtt chr3:193432496-193432576 8 9.87e-05 agaggct taggagga aagaatggtt chr1:151334991-151335071 10 9.87e-05 ccagaggcc taggagga ctgaatggtt chr2:62504974-62505054 26 9.87e-05 ctctgaggcc taggagga ctaaatggtt chr6:147286393-147286473 42 9.87e-05 ctgggaggcc taggagga cagaatggtt chr2:136288863-136288943 38 1.52e-04 CTCCGCGGCC TGGGAGGA GGTAAAGGGG chr2:220094384-220094464 64 2.25e-04 CTAAAGTCTC GAGGCGGG TCTTGGACA chr17:38574302-38574382 16 2.25e-04 TCAGGTTAGG GAGGCGGG ACTAGAGAGG chr19:6372600-6372680 56 2.25e-04 CTCAAGAGAG GAGGCGGG TTCTGGAAAA chr19:48972389-48972469 10 2.25e-04 GTTGTTTCG GAGGCGGG GCCTGCTGCC chr1:6845266-6845346 43 2.25e-04 GGGAGTGGGT GGGGAGGG GGCGTTGATT chr22:29999342-29999422 51 2.25e-04 CACCCCAAAG GAGGCGGG ACGGAGCGGG chr2:44395622-44395702 72 2.25e-04 GGACCTAGCG GAGGCGGG G chr7:2884050-2884130 70 2.25e-04 GACGCCGAAA GAGGCGGG ATC chr2:65283343-65283423 35 2.74e-04 GACGAAGTAG GGGGCGGG CTCATCTTGC chr19:51161507-51161587 52 2.74e-04 AGGGTGCTGA GGGGCGGG CCCCGGAGCC chr17:26368560-26368640 34 2.74e-04 TCCCGGATCG GGGGCGGG ATTTCCCCGG chr11:68228033-68228113 63 2.74e-04 TAGGTAGTAG GGGGCGGG AGAGAGGGGC chr22:21996434-21996514 33 2.74e-04 TCGCGAACCG GGGGCGGG CCCTCCCCGC chr4:52709128-52709208 43 2.74e-04 TGGCCAGTGG GGGGCGGG GCCTCGTTGC chr20:45035305-45035385 66 2.74e-04 CACTCAAGAA GGGGCGGG CACAGCT chr1:25757194-25757274 40 2.74e-04 GTCCTTCAAA GGGGCGGG TTCTAGAGTC chr7:150725381-150725461 41 3.96e-04 ACAGTTCCAA AAGGAGGG GGCTGACAAC chr19:12847762-12847842 59 3.96e-04 AATAACAGAG GGGGCGGA CCTGAGGTGA chr16:53537313-53537393 40 3.96e-04 CACCCCGGTT TGGGTGGG ACTGCACTTG chr19:4968814-4968894 73 3.96e-04 AGCGGGCACG TGGGTGGG chr5:37283511-37283591 64 3.96e-04 gggcctgtga tgggtggg gctgccgtg chr9:34989531-34989611 44 3.96e-04 CCGGGTGACA GGGGCGGA GGATGGGCGG chr19:11485700-11485780 28 3.96e-04 CAGCCACGAT GGGGCGGA GTCAGGCAGG chr11:63953437-63953517 7 3.96e-04 CTGAGA TGGGTGGG TTTATAGAGG chr22:40440674-40440754 4 3.96e-04 GGA GGGGCGGA ACGACAGCTT chr14:104181862-10418194 58 3.96e-04 CTCCCTGAGA GGGGCGGA GCGTACCCGG chr19:55850964-55851044 13 4.50e-04 AGTGTGAGCG AAGGCGGG ACAAGTCTCC chr6:80247190-80247270 57 4.50e-04 GTGGAACTGG AAGGCGGG ACGGCGAGTG chr3:88108232-88108312 23 4.50e-04 TAGTAGTGGA AAGGCGGG CATGAACATG chr21:39595968-39596048 38 5.27e-04 ctggatggaa aaggagga ttttattgag chr3:45112727-45112807 34 5.27e-04 aggaagaaga gaggtggg ggcaaaagga chr20:44486063-44486143 9 5.27e-04 ACCCCGGG AAGGAGGA ATCTAGGTTA chr19:46498529-46498609 63 5.27e-04 GAAGTTTTGG AGGGCGGG TTCTCCTCTG chr9:130159274-130159354 41 5.27e-04 TTTAATGTGA AGGGCGGG TCCTAGCTGA chr21:39601334-39601414 24 5.27e-04 gagagactac tgggtgga acaggaggat chr16:57769491-57769571 43 5.27e-04 TTAGGAAAAG AGGGCGGG TACTGAGGAA chr14:23790516-23790596 17 5.27e-04 CCCCGCCTTA GAGGTGGG GCCTTATTTG chr9:135905900-135905980 20 5.27e-04 GAGGTGTCAT TGGGTGGA ATACCCAGAA chr16:1728094-1728174 67 5.86e-04 TAAGTCGTCG GGGGTGGG CGTGAG chr2:119502523-119502603 69 7.23e-04 aggcctgtga taggagag gctg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KRGGMGGR MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:205124940-205125020 1.6e-05 36_[+4]_36 chr3:33007192-33007272 1.6e-05 34_[+4]_38 chr16:90121119-90121199 1.6e-05 26_[+4]_46 chr6:68832117-68832197 5.9e-05 59_[+4]_13 chr7:154518248-154518328 5.9e-05 66_[+4]_6 chr17:41397316-41397396 5.9e-05 69_[+4]_3 chr2:39587011-39587091 5.9e-05 54_[+4]_18 chr19:42901154-42901234 5.9e-05 50_[+4]_22 chr10:1026633-1026713 5.9e-05 44_[+4]_28 chr6:119404342-119404422 5.9e-05 70_[+4]_2 chr19:58960381-58960461 9.9e-05 17_[+4]_55 chr12:49504660-49504740 9.9e-05 26_[+4]_46 chr19:7822394-7822474 9.9e-05 38_[+4]_34 chr19:11485260-11485340 9.9e-05 42_[+4]_30 chr1:173439901-173439981 9.9e-05 38_[+4]_34 chr3:128578539-128578619 9.9e-05 24_[+4]_48 chr7:153273329-153273409 9.9e-05 39_[+4]_33 chr4:25225518-25225598 9.9e-05 31_[+4]_41 chrX:107062268-107062348 9.9e-05 46_[+4]_26 chr19:45394320-45394400 9.9e-05 60_[+4]_12 chr19:14228668-14228748 9.9e-05 70_[+4]_2 chr13:91304433-91304513 9.9e-05 25_[+4]_47 chr1:45723868-45723948 9.9e-05 24_[+4]_48 chr9:96891020-96891100 9.9e-05 32_[+4]_40 chr3:193432496-193432576 9.9e-05 7_[+4]_65 chr1:151334991-151335071 9.9e-05 9_[+4]_63 chr2:62504974-62505054 9.9e-05 25_[+4]_47 chr6:147286393-147286473 9.9e-05 41_[+4]_31 chr2:136288863-136288943 0.00015 37_[+4]_35 chr2:220094384-220094464 0.00023 63_[+4]_9 chr17:38574302-38574382 0.00023 15_[+4]_57 chr19:6372600-6372680 0.00023 55_[+4]_17 chr19:48972389-48972469 0.00023 9_[+4]_63 chr1:6845266-6845346 0.00023 42_[+4]_30 chr22:29999342-29999422 0.00023 50_[+4]_22 chr2:44395622-44395702 0.00023 71_[+4]_1 chr7:2884050-2884130 0.00023 69_[+4]_3 chr2:65283343-65283423 0.00027 34_[+4]_38 chr19:51161507-51161587 0.00027 51_[+4]_21 chr17:26368560-26368640 0.00027 33_[+4]_39 chr11:68228033-68228113 0.00027 62_[+4]_10 chr22:21996434-21996514 0.00027 32_[+4]_40 chr4:52709128-52709208 0.00027 42_[+4]_30 chr20:45035305-45035385 0.00027 65_[+4]_7 chr1:25757194-25757274 0.00027 39_[+4]_33 chr7:150725381-150725461 0.0004 40_[+4]_32 chr19:12847762-12847842 0.0004 58_[+4]_14 chr16:53537313-53537393 0.0004 39_[+4]_33 chr19:4968814-4968894 0.0004 72_[+4] chr5:37283511-37283591 0.0004 63_[+4]_9 chr9:34989531-34989611 0.0004 43_[+4]_29 chr19:11485700-11485780 0.0004 27_[+4]_45 chr11:63953437-63953517 0.0004 6_[+4]_66 chr22:40440674-40440754 0.0004 3_[+4]_69 chr14:104181862-10418194 0.0004 57_[+4]_15 chr19:55850964-55851044 0.00045 12_[+4]_60 chr6:80247190-80247270 0.00045 56_[+4]_16 chr3:88108232-88108312 0.00045 22_[+4]_50 chr21:39595968-39596048 0.00053 37_[+4]_35 chr3:45112727-45112807 0.00053 33_[+4]_39 chr20:44486063-44486143 0.00053 8_[+4]_64 chr19:46498529-46498609 0.00053 62_[+4]_10 chr9:130159274-130159354 0.00053 40_[+4]_32 chr21:39601334-39601414 0.00053 23_[+4]_49 chr16:57769491-57769571 0.00053 42_[+4]_30 chr14:23790516-23790596 0.00053 16_[+4]_56 chr9:135905900-135905980 0.00053 19_[+4]_53 chr16:1728094-1728174 0.00059 66_[+4]_6 chr2:119502523-119502603 0.00072 68_[+4]_4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KRGGMGGR MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF KRGGMGGR width=8 seqs=69 chr1:205124940-205125020 ( 37) TAGGAGGG 1 chr3:33007192-33007272 ( 35) TAGGAGGG 1 chr16:90121119-90121199 ( 27) TAGGAGGG 1 chr6:68832117-68832197 ( 60) TGGGAGGG 1 chr7:154518248-154518328 ( 67) TGGGAGGG 1 chr17:41397316-41397396 ( 70) TGGGAGGG 1 chr2:39587011-39587091 ( 55) TGGGAGGG 1 chr19:42901154-42901234 ( 51) TAGGCGGG 1 chr10:1026633-1026713 ( 45) TGGGAGGG 1 chr6:119404342-119404422 ( 71) TGGGAGGG 1 chr19:58960381-58960461 ( 18) TAGGAGGA 1 chr12:49504660-49504740 ( 27) TGGGCGGG 1 chr19:7822394-7822474 ( 39) TAGGAGGA 1 chr19:11485260-11485340 ( 43) TGGGCGGG 1 chr1:173439901-173439981 ( 39) TAGGAGGA 1 chr3:128578539-128578619 ( 25) TAGGAGGA 1 chr7:153273329-153273409 ( 40) TAGGAGGA 1 chr4:25225518-25225598 ( 32) TAGGAGGA 1 chrX:107062268-107062348 ( 47) TAGGAGGA 1 chr19:45394320-45394400 ( 61) TGGGCGGG 1 chr19:14228668-14228748 ( 71) TGGGCGGG 1 chr13:91304433-91304513 ( 26) TAGGAGGA 1 chr1:45723868-45723948 ( 25) TAGGAGGA 1 chr9:96891020-96891100 ( 33) TAGGAGGA 1 chr3:193432496-193432576 ( 8) TAGGAGGA 1 chr1:151334991-151335071 ( 10) TAGGAGGA 1 chr2:62504974-62505054 ( 26) TAGGAGGA 1 chr6:147286393-147286473 ( 42) TAGGAGGA 1 chr2:136288863-136288943 ( 38) TGGGAGGA 1 chr2:220094384-220094464 ( 64) GAGGCGGG 1 chr17:38574302-38574382 ( 16) GAGGCGGG 1 chr19:6372600-6372680 ( 56) GAGGCGGG 1 chr19:48972389-48972469 ( 10) GAGGCGGG 1 chr1:6845266-6845346 ( 43) GGGGAGGG 1 chr22:29999342-29999422 ( 51) GAGGCGGG 1 chr2:44395622-44395702 ( 72) GAGGCGGG 1 chr7:2884050-2884130 ( 70) GAGGCGGG 1 chr2:65283343-65283423 ( 35) GGGGCGGG 1 chr19:51161507-51161587 ( 52) GGGGCGGG 1 chr17:26368560-26368640 ( 34) GGGGCGGG 1 chr11:68228033-68228113 ( 63) GGGGCGGG 1 chr22:21996434-21996514 ( 33) GGGGCGGG 1 chr4:52709128-52709208 ( 43) GGGGCGGG 1 chr20:45035305-45035385 ( 66) GGGGCGGG 1 chr1:25757194-25757274 ( 40) GGGGCGGG 1 chr7:150725381-150725461 ( 41) AAGGAGGG 1 chr19:12847762-12847842 ( 59) GGGGCGGA 1 chr16:53537313-53537393 ( 40) TGGGTGGG 1 chr19:4968814-4968894 ( 73) TGGGTGGG 1 chr5:37283511-37283591 ( 64) TGGGTGGG 1 chr9:34989531-34989611 ( 44) GGGGCGGA 1 chr19:11485700-11485780 ( 28) GGGGCGGA 1 chr11:63953437-63953517 ( 7) TGGGTGGG 1 chr22:40440674-40440754 ( 4) GGGGCGGA 1 chr14:104181862-10418194 ( 58) GGGGCGGA 1 chr19:55850964-55851044 ( 13) AAGGCGGG 1 chr6:80247190-80247270 ( 57) AAGGCGGG 1 chr3:88108232-88108312 ( 23) AAGGCGGG 1 chr21:39595968-39596048 ( 38) AAGGAGGA 1 chr3:45112727-45112807 ( 34) GAGGTGGG 1 chr20:44486063-44486143 ( 9) AAGGAGGA 1 chr19:46498529-46498609 ( 63) AGGGCGGG 1 chr9:130159274-130159354 ( 41) AGGGCGGG 1 chr21:39601334-39601414 ( 24) TGGGTGGA 1 chr16:57769491-57769571 ( 43) AGGGCGGG 1 chr14:23790516-23790596 ( 17) GAGGTGGG 1 chr9:135905900-135905980 ( 20) TGGGTGGA 1 chr16:1728094-1728174 ( 67) GGGGTGGG 1 chr2:119502523-119502603 ( 69) TAGGAGAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KRGGMGGR MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.85237 E= 3.4e-012 -74 -1275 35 122 118 -1275 89 -1275 -1275 -1275 187 -1275 -1275 -1275 187 -1275 95 66 -1275 -78 -1275 -1275 187 -1275 -391 -1275 185 -1275 67 -1275 125 -1275 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KRGGMGGR MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 69 E= 3.4e-012 0.130435 0.000000 0.347826 0.521739 0.492754 0.000000 0.507246 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.420290 0.449275 0.000000 0.130435 0.000000 0.000000 1.000000 0.000000 0.014493 0.000000 0.985507 0.000000 0.347826 0.000000 0.652174 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KRGGMGGR MEME-4 regular expression -------------------------------------------------------------------------------- [TG][GA]GG[CA]GG[GA] -------------------------------------------------------------------------------- Time 15.81 secs. ******************************************************************************** ******************************************************************************** MOTIF MTGASTCA MEME-5 width = 8 sites = 25 llr = 232 E-value = 2.1e-005 ******************************************************************************** -------------------------------------------------------------------------------- Motif MTGASTCA MEME-5 Description -------------------------------------------------------------------------------- Simplified A 6::a:1:a pos.-specific C 4:::6:9: probability G ::a:4::: matrix T :a:::91: bits 2.2 * * * 2.0 *** * 1.8 *** * * 1.5 *** *** Relative 1.3 *** *** Entropy 1.1 **** *** (13.4 bits) 0.9 **** *** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel ATGACTCA consensus C G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MTGASTCA MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr18:44711173-44711253 4 1.16e-05 agc atgactca gcaggtttgg chr5:5409428-5409508 40 1.16e-05 aacagcctgg atgactca gcaggtttgt chr4:24967443-24967523 8 1.16e-05 acacagc atgactca gcaggtttgg chr5:103521919-103521999 18 1.16e-05 ctggtgcagc atgactca gcgggtttgg chr11:75759977-75760057 38 1.16e-05 aacagcccac atgactca gcgggattgg chr11:74255212-74255292 16 1.16e-05 ccagcacagc atgactca gcaggtttgg chr5:59009102-59009182 20 1.16e-05 caggtccagc atgactca gcaagtttgg chr10:72411567-72411647 2 1.16e-05 c atgactca gtgggtttgg chr4:84299752-84299832 10 1.16e-05 caggccagc atgactca gcaagtttgg chr10:72408389-72408469 19 1.16e-05 ccagtgcagc atgactca atgggtttgg chrX:46988603-46988683 73 3.78e-05 TCAAGGGCCC CTGACTCA chr6:28324893-28324973 67 5.24e-05 tccaatcctg ctgagtca tgcagg chr6:153168157-153168237 27 5.24e-05 tccaaaccct ctgagtca tgctgcatgg chr14:62129365-62129445 26 5.24e-05 ACCCATCTTG CTGAGTCA TGCTAAACCT chr2:149011446-149011526 40 5.24e-05 tccaaacctg ctgagtca tgctgcgctg chr6:99474201-99474281 58 5.24e-05 tccaaaccca ctgagtca tgaggctcca chr4:84886451-84886531 52 5.24e-05 tccaaacctg ctgagtca tgctggactg chr5:68228801-68228881 73 5.24e-05 tccaaacctg ctgagtca chr17:58635383-58635463 53 5.24e-05 tccaaacttg ctgagtca tgtgggatgt chr1:196504992-196505072 55 5.24e-05 tccaaacctg ctgagtca cactgtgtca chr6:137510163-137510243 15 6.15e-05 taactttatt atgactta cacagaccat chr7:64869079-64869159 14 6.15e-05 atgggtaagc atgactta ccccattgct chr5:171847690-171847770 62 7.27e-05 AGTTGAGCCT ATGACACA CAATAATGTG chr18:64967862-64967942 25 7.27e-05 tcagtacagc atgacaca gcaggtttgg chr19:12662378-12662458 12 8.18e-05 TGATTGGGTG ATGATTCA AGTCCTGCCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MTGASTCA MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr18:44711173-44711253 1.2e-05 3_[+5]_69 chr5:5409428-5409508 1.2e-05 39_[+5]_33 chr4:24967443-24967523 1.2e-05 7_[+5]_65 chr5:103521919-103521999 1.2e-05 17_[+5]_55 chr11:75759977-75760057 1.2e-05 37_[+5]_35 chr11:74255212-74255292 1.2e-05 15_[+5]_57 chr5:59009102-59009182 1.2e-05 19_[+5]_53 chr10:72411567-72411647 1.2e-05 1_[+5]_71 chr4:84299752-84299832 1.2e-05 9_[+5]_63 chr10:72408389-72408469 1.2e-05 18_[+5]_54 chrX:46988603-46988683 3.8e-05 72_[+5] chr6:28324893-28324973 5.2e-05 66_[+5]_6 chr6:153168157-153168237 5.2e-05 26_[+5]_46 chr14:62129365-62129445 5.2e-05 25_[+5]_47 chr2:149011446-149011526 5.2e-05 39_[+5]_33 chr6:99474201-99474281 5.2e-05 57_[+5]_15 chr4:84886451-84886531 5.2e-05 51_[+5]_21 chr5:68228801-68228881 5.2e-05 72_[+5] chr17:58635383-58635463 5.2e-05 52_[+5]_20 chr1:196504992-196505072 5.2e-05 54_[+5]_18 chr6:137510163-137510243 6.1e-05 14_[+5]_58 chr7:64869079-64869159 6.1e-05 13_[+5]_59 chr5:171847690-171847770 7.3e-05 61_[+5]_11 chr18:64967862-64967942 7.3e-05 24_[+5]_48 chr19:12662378-12662458 8.2e-05 11_[+5]_61 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MTGASTCA MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF MTGASTCA width=8 seqs=25 chr18:44711173-44711253 ( 4) ATGACTCA 1 chr5:5409428-5409508 ( 40) ATGACTCA 1 chr4:24967443-24967523 ( 8) ATGACTCA 1 chr5:103521919-103521999 ( 18) ATGACTCA 1 chr11:75759977-75760057 ( 38) ATGACTCA 1 chr11:74255212-74255292 ( 16) ATGACTCA 1 chr5:59009102-59009182 ( 20) ATGACTCA 1 chr10:72411567-72411647 ( 2) ATGACTCA 1 chr4:84299752-84299832 ( 10) ATGACTCA 1 chr10:72408389-72408469 ( 19) ATGACTCA 1 chrX:46988603-46988683 ( 73) CTGACTCA 1 chr6:28324893-28324973 ( 67) CTGAGTCA 1 chr6:153168157-153168237 ( 27) CTGAGTCA 1 chr14:62129365-62129445 ( 26) CTGAGTCA 1 chr2:149011446-149011526 ( 40) CTGAGTCA 1 chr6:99474201-99474281 ( 58) CTGAGTCA 1 chr4:84886451-84886531 ( 52) CTGAGTCA 1 chr5:68228801-68228881 ( 73) CTGAGTCA 1 chr17:58635383-58635463 ( 53) CTGAGTCA 1 chr1:196504992-196505072 ( 55) CTGAGTCA 1 chr6:137510163-137510243 ( 15) ATGACTTA 1 chr7:64869079-64869159 ( 14) ATGACTTA 1 chr5:171847690-171847770 ( 62) ATGACACA 1 chr18:64967862-64967942 ( 25) ATGACACA 1 chr19:12662378-12662458 ( 12) ATGATTCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MTGASTCA MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.6437 E= 2.1e-005 146 49 -1129 -1129 -1129 -1129 -1129 216 -1129 -1129 187 -1129 220 -1129 -1129 -1129 -1129 107 40 -248 -144 -1129 -1129 204 -1129 169 -1129 -148 220 -1129 -1129 -1129 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MTGASTCA MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 25 E= 2.1e-005 0.600000 0.400000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.600000 0.360000 0.040000 0.080000 0.000000 0.000000 0.920000 0.000000 0.920000 0.000000 0.080000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif MTGASTCA MEME-5 regular expression -------------------------------------------------------------------------------- [AC]TGA[CG]TCA -------------------------------------------------------------------------------- Time 19.20 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr6:68790113-68790193 9.98e-01 80 chr18:64967862-64967942 1.31e-01 24_[+5(7.27e-05)]_48 chr11:69149875-69149955 9.70e-01 80 chr1:196504992-196505072 2.11e-02 54_[+5(5.24e-05)]_18 chr11:59936928-59937008 3.55e-01 80 chr10:72408389-72408469 1.87e-03 18_[+5(1.16e-05)]_54 chr17:58635383-58635463 9.41e-02 52_[+5(5.24e-05)]_20 chr7:146207333-146207413 1.50e-01 80 chrX:46988603-46988683 1.67e-02 72_[+5(3.78e-05)] chr4:48782431-48782511 3.58e-01 80 chr4:84299752-84299832 5.55e-02 9_[+5(1.16e-05)]_63 chr7:73762050-73762130 9.09e-01 80 chr19:11457022-11457102 7.12e-02 80 chr1:25757194-25757274 9.45e-03 80 chr6:147286393-147286473 3.80e-03 41_[+4(9.87e-05)]_31 chr10:104261969-10426204 2.04e-03 33_[+2(8.23e-05)]_17_[+1(2.07e-05)]_\ 14 chr20:45035305-45035385 1.49e-01 80 chr16:90121119-90121199 2.19e-04 1_[+3(9.79e-05)]_17_[+4(1.64e-05)]_\ 46 chr22:37172211-37172291 2.06e-02 80 chr19:36193341-36193421 2.36e-01 80 chr4:41296618-41296698 2.59e-01 80 chr2:62504974-62505054 3.91e-03 25_[+4(9.87e-05)]_47 chr8:145159253-145159333 2.52e-01 80 chr11:107798882-10779896 1.03e-01 14_[+2(8.23e-05)]_58 chr2:71454302-71454382 1.76e-01 80 chr13:20532724-20532804 6.10e-02 80 chr10:72411567-72411647 2.38e-02 1_[+5(1.16e-05)]_71 chr4:52709128-52709208 2.76e-03 80 chr17:39943145-39943225 2.35e-02 80 chr21:47604557-47604637 4.90e-01 80 chr1:113932898-113932978 1.20e-01 80 chr22:35696153-35696233 1.23e-01 80 chr1:151254567-151254647 7.12e-01 80 chr7:2884050-2884130 5.45e-03 3_[+2(5.56e-05)]_69 chr5:171847690-171847770 1.44e-03 11_[+2(8.23e-05)]_42_[+5(7.27e-05)]_\ 11 chr1:151334991-151335071 2.60e-03 9_[+4(9.87e-05)]_63 chr2:44395622-44395702 2.89e-01 80 chr1:61543722-61543802 7.38e-02 80 chr17:74667893-74667973 2.80e-01 80 chr19:19174454-19174534 5.80e-01 80 chr14:96001179-96001259 2.01e-02 80 chr17:4870673-4870753 1.87e-01 80 chr5:59009102-59009182 9.29e-02 19_[+5(1.16e-05)]_53 chr6:119404342-119404422 8.00e-05 34_[+1(6.51e-05)]_3_[+3(1.62e-05)]_\ 17_[+4(5.86e-05)]_2 chr22:29999342-29999422 3.52e-02 80 chr19:13906048-13906128 8.80e-01 80 chr19:54641269-54641349 1.66e-01 80 chr5:68228801-68228881 5.50e-02 72_[+5(5.24e-05)] chr16:1728094-1728174 1.49e-01 80 chr3:33007192-33007272 1.43e-03 34_[+4(1.64e-05)]_38 chr3:193432496-193432576 1.67e-02 7_[+4(9.87e-05)]_65 chr2:73460461-73460541 4.45e-02 69_[+2(5.56e-05)]_3 chr6:32146015-32146095 1.42e-02 37_[+1(6.51e-05)]_35 chr9:135905900-135905980 1.88e-02 68_[+2(2.05e-05)]_4 chr1:168233682-168233762 6.62e-01 80 chr12:113658920-11365900 5.06e-02 80 chr9:96891020-96891100 7.96e-03 32_[+4(9.87e-05)]_40 chr1:227473630-227473710 1.04e-03 31_[+1(6.51e-05)]_3_[+3(1.62e-05)]_\ 30 chr14:23790516-23790596 2.48e-01 80 chr22:21996434-21996514 1.13e-01 80 chr15:75744241-75744321 2.60e-01 80 chr11:68228033-68228113 1.02e-01 80 chr3:88108232-88108312 1.54e-03 80 chr1:45723868-45723948 2.69e-02 24_[+4(9.87e-05)]_48 chr14:104181862-10418194 1.25e-03 26_[+1(2.99e-05)]_46 chr11:74255212-74255292 8.28e-03 15_[+5(1.16e-05)]_57 chr4:84886451-84886531 5.54e-02 51_[+5(5.24e-05)]_21 chr22:40440674-40440754 4.34e-02 80 chr10:1026633-1026713 1.61e-04 8_[+1(6.51e-05)]_3_[+3(8.51e-05)]_\ 17_[+4(5.86e-05)]_28 chr13:91304433-91304513 2.30e-02 25_[+4(9.87e-05)]_47 chrX:49125725-49125805 1.36e-01 12_[+2(6.74e-05)]_60 chr14:78083257-78083337 7.95e-01 80 chr19:14228668-14228748 1.60e-02 70_[+4(9.87e-05)]_2 chr9:124133575-124133655 1.38e-01 80 chr11:75759977-75760057 1.94e-02 37_[+5(1.16e-05)]_35 chr19:50379500-50379580 6.88e-01 80 chr1:38397514-38397594 1.35e-02 30_[+3(4.43e-05)]_42 chr6:80247190-80247270 2.41e-02 5_[+2(8.23e-05)]_22_[+2(6.74e-05)]_\ 37 chr2:6985634-6985714 6.20e-01 80 chr19:6292200-6292280 2.06e-01 80 chr7:86834437-86834517 1.60e-03 58_[+1(6.51e-05)]_3_[+3(1.62e-05)]_\ 3 chr3:194489976-194490056 5.68e-02 80 chr6:99474201-99474281 2.26e-02 57_[+5(5.24e-05)]_15 chr17:46125544-46125624 6.62e-02 80 chr1:205124940-205125020 2.10e-04 11_[+3(8.51e-05)]_17_[+4(1.64e-05)]_\ 36 chrX:49047657-49047737 1.76e-01 80 chr11:67275739-67275819 1.77e-01 80 chr9:90070478-90070558 2.43e-03 53_[+1(6.51e-05)]_3_[+3(1.62e-05)]_\ 8 chr1:6845266-6845346 2.00e-02 80 chr19:2945014-2945094 2.38e-01 80 chr16:16075435-16075515 4.66e-02 68_[+3(1.62e-05)]_4 chr11:63953437-63953517 1.01e-01 80 chr16:639263-639343 1.31e-01 80 chr7:100825844-100825924 1.06e-01 80 chr9:128003812-128003892 2.13e-02 57_[+2(3.23e-05)]_15 chr17:61627663-61627743 9.88e-02 48_[+1(2.99e-05)]_24 chr14:73925421-73925501 7.99e-02 36_[+2(5.56e-05)]_36 chr7:100184146-100184226 1.59e-01 80 chr19:18315100-18315180 3.61e-03 32_[+1(8.87e-05)]_40 chr9:139780750-139780830 1.08e-01 80 chr1:12282943-12283023 3.72e-04 [+1(6.51e-05)]_3_[+3(1.62e-05)]_61 chr19:3971230-3971310 9.73e-02 56_[+2(8.23e-05)]_16 chr18:77782817-77782897 2.93e-01 80 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******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n06.farnam.hpc.yale.internal ********************************************************************************