******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/CCNT2.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr19:1123173-1123253 1.0000 80 chr16:8962302-8962382 1.0000 80 chr3:170074716-170074796 1.0000 80 chr5:139088927-139089007 1.0000 80 chr22:22863041-22863121 1.0000 80 chr14:65346688-65346768 1.0000 80 chr3:127795824-127795904 1.0000 80 chr19:13961361-13961441 1.0000 80 chr17:42061349-42061429 1.0000 80 chr1:59281052-59281132 1.0000 80 chr14:50470138-50470218 1.0000 80 chr8:103666285-103666365 1.0000 80 chr14:75743869-75743949 1.0000 80 chr12:53268121-53268201 1.0000 80 chr11:65189710-65189790 1.0000 80 chr8:145561958-145562038 1.0000 80 chr2:8818980-8819060 1.0000 80 chr1:209848512-209848592 1.0000 80 chr8:99956554-99956634 1.0000 80 chr2:128165692-128165772 1.0000 80 chr1:59282062-59282142 1.0000 80 chr10:11653718-11653798 1.0000 80 chr19:18268035-18268115 1.0000 80 chr19:13162606-13162686 1.0000 80 chr17:76254812-76254892 1.0000 80 chr17:76356218-76356298 1.0000 80 chr1:41826853-41826933 1.0000 80 chr19:40939915-40939995 1.0000 80 chr8:103819001-103819081 1.0000 80 chrX:18372851-18372931 1.0000 80 chr2:145090062-145090142 1.0000 80 chr3:176915563-176915643 1.0000 80 chr1:1850908-1850988 1.0000 80 chr9:114937561-114937641 1.0000 80 chr5:141736717-141736797 1.0000 80 chr1:859211-859291 1.0000 80 chr2:242823864-242823944 1.0000 80 chr1:44495793-44495873 1.0000 80 chr2:10183524-10183604 1.0000 80 chr19:4328520-4328600 1.0000 80 chr2:17699748-17699828 1.0000 80 chr19:18854226-18854306 1.0000 80 chr6:44044393-44044473 1.0000 80 chr19:2169122-2169202 1.0000 80 chr19:10654375-10654455 1.0000 80 chr11:65341814-65341894 1.0000 80 chr12:52430791-52430871 1.0000 80 chr5:95066905-95066985 1.0000 80 chr19:39894597-39894677 1.0000 80 chr12:94136121-94136201 1.0000 80 chr12:8123378-8123458 1.0000 80 chr19:14628770-14628850 1.0000 80 chr2:200320549-200320629 1.0000 80 chr2:64872346-64872426 1.0000 80 chr6:43737832-43737912 1.0000 80 chr14:104625341-10462542 1.0000 80 chr3:39195151-39195231 1.0000 80 chr9:132250905-132250985 1.0000 80 chr8:106334003-106334083 1.0000 80 chr9:115095265-115095345 1.0000 80 chr22:42229011-42229091 1.0000 80 chr16:88522346-88522426 1.0000 80 chrX:71238430-71238510 1.0000 80 chr21:44394383-44394463 1.0000 80 chr5:141392586-141392666 1.0000 80 chr12:96793198-96793278 1.0000 80 chr15:95388161-95388241 1.0000 80 chr10:6205755-6205835 1.0000 80 chr11:34460179-34460259 1.0000 80 chr7:105752767-105752847 1.0000 80 chr9:129987421-129987501 1.0000 80 chr3:5229261-5229341 1.0000 80 chr17:27503801-27503881 1.0000 80 chr1:45501464-45501544 1.0000 80 chr16:85587084-85587164 1.0000 80 chr7:50237316-50237396 1.0000 80 chr3:193852856-193852936 1.0000 80 chr7:105925662-105925742 1.0000 80 chrX:40032040-40032120 1.0000 80 chr19:46272721-46272801 1.0000 80 chr17:49022042-49022122 1.0000 80 chr19:40927215-40927295 1.0000 80 chr19:41129924-41130004 1.0000 80 chr12:4430148-4430228 1.0000 80 chr5:131831599-131831679 1.0000 80 chr15:66914590-66914670 1.0000 80 chr1:159894404-159894484 1.0000 80 chr18:77267146-77267226 1.0000 80 chr17:37823910-37823990 1.0000 80 chr12:46765184-46765264 1.0000 80 chr6:89791463-89791543 1.0000 80 chr18:46474969-46475049 1.0000 80 chr14:74226941-74227021 1.0000 80 chr16:31117221-31117301 1.0000 80 chr1:6663054-6663134 1.0000 80 chr6:157041203-157041283 1.0000 80 chr5:39425002-39425082 1.0000 80 chr19:45947641-45947721 1.0000 80 chr18:6683235-6683315 1.0000 80 chr2:172963888-172963968 1.0000 80 chr17:61819217-61819297 1.0000 80 chr19:41732168-41732248 1.0000 80 chr15:68177053-68177133 1.0000 80 chr20:32319943-32320023 1.0000 80 chr10:30359156-30359236 1.0000 80 chr3:12994875-12994955 1.0000 80 chr12:122235204-12223528 1.0000 80 chr16:69599768-69599848 1.0000 80 chr4:39699597-39699677 1.0000 80 chr1:43871045-43871125 1.0000 80 chr1:245026524-245026604 1.0000 80 chr18:3013337-3013417 1.0000 80 chr7:106685007-106685087 1.0000 80 chr6:12009278-12009358 1.0000 80 chr11:76494266-76494346 1.0000 80 chr1:54955097-54955177 1.0000 80 chr20:30160931-30161011 1.0000 80 chr3:141765326-141765406 1.0000 80 chr12:49628334-49628414 1.0000 80 chr8:145597637-145597717 1.0000 80 chr6:32163618-32163698 1.0000 80 chr2:171679681-171679761 1.0000 80 chr11:2800018-2800098 1.0000 80 chr13:115046891-11504697 1.0000 80 chr16:89043517-89043597 1.0000 80 chr19:10613459-10613539 1.0000 80 chr1:23881353-23881433 1.0000 80 chr3:8671295-8671375 1.0000 80 chr12:111806877-11180695 1.0000 80 chr1:27693031-27693111 1.0000 80 chr1:54954008-54954088 1.0000 80 chr18:12407836-12407916 1.0000 80 chr8:21917530-21917610 1.0000 80 chr11:3253146-3253226 1.0000 80 chr1:206730532-206730612 1.0000 80 chr6:31870080-31870160 1.0000 80 chr6:44041115-44041195 1.0000 80 chr6:37070496-37070576 1.0000 80 chr5:90676054-90676134 1.0000 80 chr6:44214128-44214208 1.0000 80 chr3:193720973-193721053 1.0000 80 chr2:43453725-43453805 1.0000 80 chr2:176866989-176867069 1.0000 80 chr17:42402214-42402294 1.0000 80 chr6:119256293-119256373 1.0000 80 chr1:92912291-92912371 1.0000 80 chr16:87086972-87087052 1.0000 80 chr5:133801606-133801686 1.0000 80 chr5:90576432-90576512 1.0000 80 chr19:16369379-16369459 1.0000 80 chr6:34759797-34759877 1.0000 80 chr10:92980168-92980248 1.0000 80 chr1:23884946-23885026 1.0000 80 chr6:134496152-134496232 1.0000 80 chr1:29359597-29359677 1.0000 80 chr16:85647048-85647128 1.0000 80 chr19:2273790-2273870 1.0000 80 chr7:102036782-102036862 1.0000 80 chr8:103666495-103666575 1.0000 80 chr7:149119524-149119604 1.0000 80 chr10:80733353-80733433 1.0000 80 chr11:70588861-70588941 1.0000 80 chr4:139592826-139592906 1.0000 80 chr17:27070962-27071042 1.0000 80 chr6:108880467-108880547 1.0000 80 chr7:5594686-5594766 1.0000 80 chr10:51572378-51572458 1.0000 80 chr4:39640634-39640714 1.0000 80 chr9:94662439-94662519 1.0000 80 chr19:13273898-13273978 1.0000 80 chr15:66923458-66923538 1.0000 80 chr2:219260827-219260907 1.0000 80 chr3:23987415-23987495 1.0000 80 chr9:114658879-114658959 1.0000 80 chr12:46777236-46777316 1.0000 80 chr19:907340-907420 1.0000 80 chr10:52086694-52086774 1.0000 80 chr19:13030142-13030222 1.0000 80 chr16:67596140-67596220 1.0000 80 chr8:41655184-41655264 1.0000 80 chr19:45943226-45943306 1.0000 80 chr10:11643792-11643872 1.0000 80 chrX:48644361-48644441 1.0000 80 chr1:30601976-30602056 1.0000 80 chr19:18110552-18110632 1.0000 80 chr20:361457-361537 1.0000 80 chr20:60697208-60697288 1.0000 80 chr16:50875119-50875199 1.0000 80 chr2:158732992-158733072 1.0000 80 chr1:225615953-225616033 1.0000 80 chr3:156825743-156825823 1.0000 80 chr9:119228579-119228659 1.0000 80 chr5:131826589-131826669 1.0000 80 chr7:26241257-26241337 1.0000 80 chr19:45970853-45970933 1.0000 80 chr1:8763479-8763559 1.0000 80 chr11:65667960-65668040 1.0000 80 chr7:155089317-155089397 1.0000 80 chr19:10025456-10025536 1.0000 80 chr17:36886360-36886440 1.0000 80 chr19:48825294-48825374 1.0000 80 chr19:13266453-13266533 1.0000 80 chr2:242786447-242786527 1.0000 80 chr1:40042513-40042593 1.0000 80 chr19:39340038-39340118 1.0000 80 chr11:73727497-73727577 1.0000 80 chr15:67095638-67095718 1.0000 80 chr7:5569517-5569597 1.0000 80 chr2:64978627-64978707 1.0000 80 chr17:35969505-35969585 1.0000 80 chr8:130951947-130952027 1.0000 80 chr3:93692680-93692760 1.0000 80 chr5:177540475-177540555 1.0000 80 chr2:97523771-97523851 1.0000 80 chr7:56131925-56132005 1.0000 80 chr6:135502339-135502419 1.0000 80 chr1:94375082-94375162 1.0000 80 chr7:91184354-91184434 1.0000 80 chr17:56429673-56429753 1.0000 80 chr4:125634030-125634110 1.0000 80 chr5:60704670-60704750 1.0000 80 chr2:85766864-85766944 1.0000 80 chr15:83316414-83316494 1.0000 80 chr18:9708186-9708266 1.0000 80 chr1:38999702-38999782 1.0000 80 chr20:61425826-61425906 1.0000 80 chr6:33378152-33378232 1.0000 80 chrX:48641399-48641479 1.0000 80 chr11:47198565-47198645 1.0000 80 chr7:135718301-135718381 1.0000 80 chr1:51701899-51701979 1.0000 80 chr1:26438195-26438275 1.0000 80 chr19:54372737-54372817 1.0000 80 chr10:133795508-13379558 1.0000 80 chr8:141629171-141629251 1.0000 80 chr2:191878968-191879048 1.0000 80 chr12:93964718-93964798 1.0000 80 chr11:34073746-34073826 1.0000 80 chr11:47574756-47574836 1.0000 80 chr17:27224616-27224696 1.0000 80 chr1:109102585-109102665 1.0000 80 chr11:65264992-65265072 1.0000 80 chr9:126122613-126122693 1.0000 80 chr6:26172193-26172273 1.0000 80 chr7:149468927-149469007 1.0000 80 chr10:124894718-12489479 1.0000 80 chr19:944255-944335 1.0000 80 chrX:40943854-40943934 1.0000 80 chr21:46494171-46494251 1.0000 80 chr17:7146400-7146480 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_CCNT2/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/CCNT2.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.134 C 0.374 G 0.368 T 0.124 Background letter frequencies (from file dataset with add-one prior applied): A 0.134 C 0.374 G 0.368 T 0.124 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TTATCTBH MEME-1 width = 8 sites = 35 llr = 328 E-value = 1.1e-018 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTATCTBH MEME-1 Description -------------------------------------------------------------------------------- Simplified A :19::1:3 pos.-specific C 111:7:34 probability G ::::::3: matrix T 97:a2933 bits 3.0 * 2.7 * 2.4 * ** * 2.1 * ** * Relative 1.8 * ** * Entropy 1.5 **** * (13.5 bits) 1.2 **** * 0.9 **** * * 0.6 ****** * 0.3 ******** 0.0 -------- Multilevel TTATCTCC consensus T TT sequence GA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTATCTBH MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:92912291-92912371 50 2.43e-07 AAGACCAGAT TTATCTTT GGAAACCAAG chr3:12994875-12994955 72 2.43e-07 GGCTGCAGCA TTATCTTT A chr16:88522346-88522426 54 2.43e-07 ATAAGAGGCC TTATCTTT GGCCACCAGG chr18:77267146-77267226 65 5.05e-07 CCAGCTGCTG TTATTTTA GATATGGC chr8:141629171-141629251 23 1.97e-06 AGCCGCGGCC TTATCTCT GTGATGCAGA chr9:119228579-119228659 59 1.97e-06 CCACCTTCTC TTATCTCT GCTCTGCAAC chr1:45501464-45501544 59 2.69e-06 AGCCAGTTAT TTATCTGT ATGCTTCCAT chr1:225615953-225616033 71 3.48e-06 TGCCACCGCC TTATCTCA GC chr10:11643792-11643872 59 3.48e-06 TTGTGCTGTC TTATCTCA GCTGTCTGAC chr5:139088927-139089007 61 4.26e-06 GCCCGCCCGC TTATCTGA TCTGCGGCTA chr19:944255-944335 14 7.01e-06 TGTCTCGCCG TTATCTCC CAGGCGTGTC chr8:145561958-145562038 34 7.01e-06 ggccgccccc TTATCTCC GAGCGGCAGC chrX:48641399-48641479 15 9.25e-06 ACTGATTCCC TTATCTGC CCACTCCCAG chr11:73727497-73727577 46 9.25e-06 CTAGGGGGCC TTATCTGC AAGGCCCAGG chrX:48644361-48644441 22 9.25e-06 CTGATAAGAC TTATCTGC TGCCCCAGGG chr15:66914590-66914670 50 9.25e-06 GCCCTGGGCG TTATCTGC GCTAGCCCGG chr1:38999702-38999782 30 1.30e-05 CAGAtctatg tcatcttt gaaagtacta chr2:17699748-17699828 50 1.40e-05 GGCCTTAGCC TAATCTCA GGGTTTgccc chr12:52430791-52430871 33 1.84e-05 CCGGGCGCCG CTATTTTT AGCCCCATTG chr10:52086694-52086774 5 2.12e-05 AATG ATATTTTA ACAATTTGGC chr19:10025456-10025536 11 2.45e-05 GGGCTAGTTT TAATTTCC TCTGTTTTGC chr10:92980168-92980248 32 3.06e-05 AGAACCGAGA TAATATTT GGCCAGAGCT chr3:176915563-176915643 12 3.42e-05 GTGCGGCGCA TTCTTTTA AAAATCAGGC chr3:156825743-156825823 10 4.15e-05 CAAGAAATC TGATTTTT AGCAGTGCTG chr8:106334003-106334083 41 5.21e-05 AGAAACCCGA TTATTACC ATTAAAATTC chr7:91184354-91184434 11 5.81e-05 TGTAGGCATC TTATCAGC ACGAAACAGC chr19:18854226-18854306 61 6.18e-05 GTGCACAGCC TTATCGTA AACAGGAGAT chr17:76356218-76356298 25 7.08e-05 GGCCTTCTTG TAATGTTT AGTCACTACT chr7:135718301-135718381 37 7.97e-05 CTCACTCGTC TCATCTCC AGCTCCCAGG chr16:50875119-50875199 2 8.97e-05 T TCATTTGC AAGTCACTGC chr9:132250905-132250985 9 8.97e-05 GGCTGATG TCATCTGC ACACAACTTT chr10:30359156-30359236 72 1.02e-04 AATGTTTCCT TTCTCTGA C chr12:49628334-49628414 63 1.22e-04 GCAGGCGGCG CTATCTCC AGGCCGCAGC chr17:49022042-49022122 29 1.22e-04 CGATTAGCAT CTATCTCC TCCCCGCCGC chr5:39425002-39425082 55 1.38e-04 GATATGGTTC TAATCAGA TGCTGGCAGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTATCTBH MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:92912291-92912371 2.4e-07 49_[+1]_23 chr3:12994875-12994955 2.4e-07 71_[+1]_1 chr16:88522346-88522426 2.4e-07 53_[+1]_19 chr18:77267146-77267226 5e-07 64_[+1]_8 chr8:141629171-141629251 2e-06 22_[+1]_50 chr9:119228579-119228659 2e-06 58_[+1]_14 chr1:45501464-45501544 2.7e-06 58_[+1]_14 chr1:225615953-225616033 3.5e-06 70_[+1]_2 chr10:11643792-11643872 3.5e-06 58_[+1]_14 chr5:139088927-139089007 4.3e-06 60_[+1]_12 chr19:944255-944335 7e-06 13_[+1]_59 chr8:145561958-145562038 7e-06 33_[+1]_39 chrX:48641399-48641479 9.2e-06 14_[+1]_58 chr11:73727497-73727577 9.2e-06 45_[+1]_27 chrX:48644361-48644441 9.2e-06 21_[+1]_51 chr15:66914590-66914670 9.2e-06 49_[+1]_23 chr1:38999702-38999782 1.3e-05 29_[+1]_43 chr2:17699748-17699828 1.4e-05 49_[+1]_23 chr12:52430791-52430871 1.8e-05 32_[+1]_40 chr10:52086694-52086774 2.1e-05 4_[+1]_68 chr19:10025456-10025536 2.4e-05 10_[+1]_62 chr10:92980168-92980248 3.1e-05 31_[+1]_41 chr3:176915563-176915643 3.4e-05 11_[+1]_61 chr3:156825743-156825823 4.1e-05 9_[+1]_63 chr8:106334003-106334083 5.2e-05 40_[+1]_32 chr7:91184354-91184434 5.8e-05 10_[+1]_62 chr19:18854226-18854306 6.2e-05 60_[+1]_12 chr17:76356218-76356298 7.1e-05 24_[+1]_48 chr7:135718301-135718381 8e-05 36_[+1]_36 chr16:50875119-50875199 9e-05 1_[+1]_71 chr9:132250905-132250985 9e-05 8_[+1]_64 chr10:30359156-30359236 0.0001 71_[+1]_1 chr12:49628334-49628414 0.00012 62_[+1]_10 chr17:49022042-49022122 0.00012 28_[+1]_44 chr5:39425002-39425082 0.00014 54_[+1]_18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTATCTBH MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTATCTBH width=8 seqs=35 chr1:92912291-92912371 ( 50) TTATCTTT 1 chr3:12994875-12994955 ( 72) TTATCTTT 1 chr16:88522346-88522426 ( 54) TTATCTTT 1 chr18:77267146-77267226 ( 65) TTATTTTA 1 chr8:141629171-141629251 ( 23) TTATCTCT 1 chr9:119228579-119228659 ( 59) TTATCTCT 1 chr1:45501464-45501544 ( 59) TTATCTGT 1 chr1:225615953-225616033 ( 71) TTATCTCA 1 chr10:11643792-11643872 ( 59) TTATCTCA 1 chr5:139088927-139089007 ( 61) TTATCTGA 1 chr19:944255-944335 ( 14) TTATCTCC 1 chr8:145561958-145562038 ( 34) TTATCTCC 1 chrX:48641399-48641479 ( 15) TTATCTGC 1 chr11:73727497-73727577 ( 46) TTATCTGC 1 chrX:48644361-48644441 ( 22) TTATCTGC 1 chr15:66914590-66914670 ( 50) TTATCTGC 1 chr1:38999702-38999782 ( 30) TCATCTTT 1 chr2:17699748-17699828 ( 50) TAATCTCA 1 chr12:52430791-52430871 ( 33) CTATTTTT 1 chr10:52086694-52086774 ( 5) ATATTTTA 1 chr19:10025456-10025536 ( 11) TAATTTCC 1 chr10:92980168-92980248 ( 32) TAATATTT 1 chr3:176915563-176915643 ( 12) TTCTTTTA 1 chr3:156825743-156825823 ( 10) TGATTTTT 1 chr8:106334003-106334083 ( 41) TTATTACC 1 chr7:91184354-91184434 ( 11) TTATCAGC 1 chr19:18854226-18854306 ( 61) TTATCGTA 1 chr17:76356218-76356298 ( 25) TAATGTTT 1 chr7:135718301-135718381 ( 37) TCATCTCC 1 chr16:50875119-50875199 ( 2) TCATTTGC 1 chr9:132250905-132250985 ( 9) TCATCTGC 1 chr10:30359156-30359236 ( 72) TTCTCTGA 1 chr12:49628334-49628414 ( 63) CTATCTCC 1 chr17:49022042-49022122 ( 29) CTATCTCC 1 chr5:39425002-39425082 ( 55) TAATCAGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTATCTBH MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.4104 E= 1.1e-018 -223 -213 -1177 284 9 -171 -368 253 281 -271 -1177 -1177 -1177 -1177 -1177 302 -223 93 -368 89 -65 -1177 -368 284 -1177 -13 -23 147 109 10 -1177 135 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTATCTBH MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 35 E= 1.1e-018 0.028571 0.085714 0.000000 0.885714 0.142857 0.114286 0.028571 0.714286 0.942857 0.057143 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.028571 0.714286 0.028571 0.228571 0.085714 0.000000 0.028571 0.885714 0.000000 0.342857 0.314286 0.342857 0.285714 0.400000 0.000000 0.314286 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTATCTBH MEME-1 regular expression -------------------------------------------------------------------------------- TTAT[CT]T[CTG][CTA] -------------------------------------------------------------------------------- Time 5.30 secs. ******************************************************************************** ******************************************************************************** MOTIF VAGATAAG MEME-2 width = 8 sites = 25 llr = 255 E-value = 6.3e-016 ******************************************************************************** -------------------------------------------------------------------------------- Motif VAGATAAG MEME-2 Description -------------------------------------------------------------------------------- Simplified A 36:a:9a: pos.-specific C 51:::::1 probability G 2:a::::9 matrix T :3::a1:: bits 3.0 * 2.7 ** * 2.4 **** 2.1 **** Relative 1.8 **** Entropy 1.5 ***** (14.7 bits) 1.2 ****** 0.9 ******* 0.6 ******* 0.3 ******** 0.0 -------- Multilevel CAGATAAG consensus AT sequence G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VAGATAAG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr9:126122613-126122693 20 7.26e-07 GGGATTTGTA AAGATAAG CACAGGCCCC chr1:29359597-29359677 66 7.26e-07 CTGGTTTACA AAGATAAG CTGAGAA chr1:45501464-45501544 39 7.26e-07 CTCCTGGAGG AAGATAAG CCAGCCAGTT chr8:106334003-106334083 5 7.26e-07 GGGA AAGATAAG CGGAGAAGAT chr16:50875119-50875199 59 2.75e-06 gcggggcgcg cAGATAAG GTCTGGGGGC chr19:45943226-45943306 8 2.75e-06 CGGCCCC CAGATAAG GCAGGACGAC chr9:94662439-94662519 17 2.75e-06 GGCAGGCCCC CAGATAAG CTCAGGATGC chr19:16369379-16369459 12 2.75e-06 CCTGAGGTCA CAGATAAG GCCGCTGGGC chr12:94136121-94136201 15 2.75e-06 GTGGGAGCTG CAGATAAG CCAGCGCTTg chr3:141765326-141765406 37 3.42e-06 TACAGAGGTA ATGATAAG AGAGATGGGA chr19:18110552-18110632 47 5.30e-06 CTGGCAGCCT CTGATAAG GCCATCCATC chrX:48644361-48644441 12 5.30e-06 TCGCCTACAT CTGATAAG ACTTATCTGC chr11:70588861-70588941 1 7.29e-06 . GAGATAAG AGGCAAGGGG chr9:114937561-114937641 12 7.29e-06 TCAGGGTGCA GAGATAAG GCTACAGGCG chr19:10654375-10654455 58 9.13e-06 TCCTGGCGGT GTGATAAG GAGGGCGGGG chr10:124894718-12489479 39 1.57e-05 GCTGCGAGCG CAGATAAC CCCGAGGTGA chr14:104625341-10462542 49 1.90e-05 GACGGGGCAT ATGATTAG GGCATTGTCG chr17:76254812-76254892 67 2.11e-05 TGGCCCCGCT GAGATAAA GGGAGG chr20:361457-361537 64 3.04e-05 CAGACGGCGG CTGATTAG CTCCGGTTT chr3:12994875-12994955 33 3.04e-05 CTGCTGAGGC CCGATAAG GCCCGGCCCA chr11:34460179-34460259 17 3.04e-05 CTGAAGGATG CTGATAAC CGGGAGCCCC chr10:92980168-92980248 13 3.88e-05 GTGGACGGTG AGGATAAG AAGAACCGAG chr16:88522346-88522426 41 5.59e-05 ATCGCCAAGA GCGATAAG AGGCCTTATC chr5:39425002-39425082 43 5.99e-05 CTCCCGGCGA GAGATATG GTTCTAATCA chr1:30601976-30602056 30 6.69e-05 GTGTCAACAG CAGACAAG AAATGTTTCT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VAGATAAG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:126122613-126122693 7.3e-07 19_[+2]_53 chr1:29359597-29359677 7.3e-07 65_[+2]_7 chr1:45501464-45501544 7.3e-07 38_[+2]_34 chr8:106334003-106334083 7.3e-07 4_[+2]_68 chr16:50875119-50875199 2.8e-06 58_[+2]_14 chr19:45943226-45943306 2.8e-06 7_[+2]_65 chr9:94662439-94662519 2.8e-06 16_[+2]_56 chr19:16369379-16369459 2.8e-06 11_[+2]_61 chr12:94136121-94136201 2.8e-06 14_[+2]_58 chr3:141765326-141765406 3.4e-06 36_[+2]_36 chr19:18110552-18110632 5.3e-06 46_[+2]_26 chrX:48644361-48644441 5.3e-06 11_[+2]_61 chr11:70588861-70588941 7.3e-06 [+2]_72 chr9:114937561-114937641 7.3e-06 11_[+2]_61 chr19:10654375-10654455 9.1e-06 57_[+2]_15 chr10:124894718-12489479 1.6e-05 38_[+2]_34 chr14:104625341-10462542 1.9e-05 48_[+2]_24 chr17:76254812-76254892 2.1e-05 66_[+2]_6 chr20:361457-361537 3e-05 63_[+2]_9 chr3:12994875-12994955 3e-05 32_[+2]_40 chr11:34460179-34460259 3e-05 16_[+2]_56 chr10:92980168-92980248 3.9e-05 12_[+2]_60 chr16:88522346-88522426 5.6e-05 40_[+2]_32 chr5:39425002-39425082 6e-05 42_[+2]_30 chr1:30601976-30602056 6.7e-05 29_[+2]_43 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VAGATAAG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF VAGATAAG width=8 seqs=25 chr9:126122613-126122693 ( 20) AAGATAAG 1 chr1:29359597-29359677 ( 66) AAGATAAG 1 chr1:45501464-45501544 ( 39) AAGATAAG 1 chr8:106334003-106334083 ( 5) AAGATAAG 1 chr16:50875119-50875199 ( 59) CAGATAAG 1 chr19:45943226-45943306 ( 8) CAGATAAG 1 chr9:94662439-94662519 ( 17) CAGATAAG 1 chr19:16369379-16369459 ( 12) CAGATAAG 1 chr12:94136121-94136201 ( 15) CAGATAAG 1 chr3:141765326-141765406 ( 37) ATGATAAG 1 chr19:18110552-18110632 ( 47) CTGATAAG 1 chrX:48644361-48644441 ( 12) CTGATAAG 1 chr11:70588861-70588941 ( 1) GAGATAAG 1 chr9:114937561-114937641 ( 12) GAGATAAG 1 chr19:10654375-10654455 ( 58) GTGATAAG 1 chr10:124894718-12489479 ( 39) CAGATAAC 1 chr14:104625341-10462542 ( 49) ATGATTAG 1 chr17:76254812-76254892 ( 67) GAGATAAA 1 chr20:361457-361537 ( 64) CTGATTAG 1 chr3:12994875-12994955 ( 33) CCGATAAG 1 chr11:34460179-34460259 ( 17) CTGATAAC 1 chr10:92980168-92980248 ( 13) AGGATAAG 1 chr16:88522346-88522426 ( 41) GCGATAAG 1 chr5:39425002-39425082 ( 43) GAGATATG 1 chr1:30601976-30602056 ( 30) CAGACAAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VAGATAAG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.6437 E= 6.3e-016 106 36 -62 -1129 216 -222 -320 118 -1129 -1129 144 -1129 290 -1129 -1129 -1129 -1129 -322 -1129 296 278 -1129 -1129 -63 284 -1129 -1129 -163 -174 -222 126 -1129 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VAGATAAG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 25 E= 6.3e-016 0.280000 0.480000 0.240000 0.000000 0.600000 0.080000 0.040000 0.280000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.040000 0.000000 0.960000 0.920000 0.000000 0.000000 0.080000 0.960000 0.000000 0.000000 0.040000 0.040000 0.080000 0.880000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif VAGATAAG MEME-2 regular expression -------------------------------------------------------------------------------- [CAG][AT]GATAAG -------------------------------------------------------------------------------- Time 9.20 secs. ******************************************************************************** ******************************************************************************** MOTIF TGASTCAC MEME-3 width = 8 sites = 18 llr = 194 E-value = 1.0e-009 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGASTCAC MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::a:::a: pos.-specific C :::3:a:6 probability G :a:6:::1 matrix T a::1a::3 bits 3.0 * * * * 2.7 * * * * 2.4 * * * * 2.1 * * * * Relative 1.8 * * * * Entropy 1.5 *** *** (15.5 bits) 1.2 *** *** 0.9 *** *** 0.6 *** **** 0.3 ******** 0.0 -------- Multilevel TGAGTCAC consensus C T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAC MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:50237316-50237396 13 1.73e-06 GCCTCAGGGA TGAGTCAT GCCGCCAGGC chr9:132250905-132250985 53 1.73e-06 CTCGGGGCCC TGAGTCAT CGCCGCCCCC chr5:90576432-90576512 11 6.96e-06 GAGTCAGCGC TGAGTCAC GCTCGGCGCT chr5:133801606-133801686 66 6.96e-06 CGGCGGGAGC TGAGTCAC GGCGGCC chr2:172963888-172963968 36 6.96e-06 CCGCGCTGAG TGAGTCAC CCCGCCGCCG chr1:6663054-6663134 53 6.96e-06 cTCCGCAGGC TGAGTCAC CGCTGTCCGC chr1:159894404-159894484 24 6.96e-06 TTACAACAGA TGAGTCAC CCACCGCCCT chrX:71238430-71238510 68 6.96e-06 GCCGGCGCGA TGAGTCAC CATCC chr19:39894597-39894677 29 6.96e-06 CCCTTGCGAG TGAGTCAC GGGCGAGCAG chr12:46777236-46777316 68 9.31e-06 CACGTGACGG TGATTCAT TCGGC chr12:46765184-46765264 61 9.31e-06 GCAGCGCGGC TGATTCAT CCCAGGCCAG chr12:53268121-53268201 31 9.31e-06 cgcTCCGCGG TGACTCAT CCAGCACCCC chr1:38999702-38999782 73 1.64e-05 acggatttca tgactcac chr3:8671295-8671375 25 1.64e-05 acaccctcac tgactcAC CAGTGGTTCA chr2:128165692-128165772 10 1.64e-05 AGGGGGCGC TGACTCAC AGGCTGACTC chr19:13961361-13961441 32 1.64e-05 cggcgcgcgg TGACTCAC CGCGGCGTGA chr5:177540475-177540555 45 2.15e-05 CGCGCGCCGG TGAGTCAG GCCGGGTTTT chr8:103819001-103819081 43 2.85e-05 cgggcgcccg TGACTCAG GGTGCGTCAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAC MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:50237316-50237396 1.7e-06 12_[+3]_60 chr9:132250905-132250985 1.7e-06 52_[+3]_20 chr5:90576432-90576512 7e-06 10_[+3]_62 chr5:133801606-133801686 7e-06 65_[+3]_7 chr2:172963888-172963968 7e-06 35_[+3]_37 chr1:6663054-6663134 7e-06 52_[+3]_20 chr1:159894404-159894484 7e-06 23_[+3]_49 chrX:71238430-71238510 7e-06 67_[+3]_5 chr19:39894597-39894677 7e-06 28_[+3]_44 chr12:46777236-46777316 9.3e-06 67_[+3]_5 chr12:46765184-46765264 9.3e-06 60_[+3]_12 chr12:53268121-53268201 9.3e-06 30_[+3]_42 chr1:38999702-38999782 1.6e-05 72_[+3] chr3:8671295-8671375 1.6e-05 24_[+3]_48 chr2:128165692-128165772 1.6e-05 9_[+3]_63 chr19:13961361-13961441 1.6e-05 31_[+3]_41 chr5:177540475-177540555 2.2e-05 44_[+3]_28 chr8:103819001-103819081 2.8e-05 42_[+3]_30 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAC MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGASTCAC width=8 seqs=18 chr7:50237316-50237396 ( 13) TGAGTCAT 1 chr9:132250905-132250985 ( 53) TGAGTCAT 1 chr5:90576432-90576512 ( 11) TGAGTCAC 1 chr5:133801606-133801686 ( 66) TGAGTCAC 1 chr2:172963888-172963968 ( 36) TGAGTCAC 1 chr1:6663054-6663134 ( 53) TGAGTCAC 1 chr1:159894404-159894484 ( 24) TGAGTCAC 1 chrX:71238430-71238510 ( 68) TGAGTCAC 1 chr19:39894597-39894677 ( 29) TGAGTCAC 1 chr12:46777236-46777316 ( 68) TGATTCAT 1 chr12:46765184-46765264 ( 61) TGATTCAT 1 chr12:53268121-53268201 ( 31) TGACTCAT 1 chr1:38999702-38999782 ( 73) TGACTCAC 1 chr3:8671295-8671375 ( 25) TGACTCAC 1 chr2:128165692-128165772 ( 10) TGACTCAC 1 chr19:13961361-13961441 ( 32) TGACTCAC 1 chr5:177540475-177540555 ( 45) TGAGTCAG 1 chr8:103819001-103819081 ( 43) TGACTCAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAC MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.3895 E= 1.0e-009 -1081 -1081 -1081 302 -1081 -1081 144 -1081 290 -1081 -1081 -1081 -1081 -17 59 -15 -1081 -1081 -1081 302 -1081 142 -1081 -1081 290 -1081 -1081 -1081 -1081 71 -173 117 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAC MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 18 E= 1.0e-009 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.555556 0.111111 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.611111 0.111111 0.277778 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAC MEME-3 regular expression -------------------------------------------------------------------------------- TGA[GC]TCA[CT] -------------------------------------------------------------------------------- Time 12.92 secs. ******************************************************************************** ******************************************************************************** MOTIF ANVAAACA MEME-4 width = 8 sites = 25 llr = 218 E-value = 6.4e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif ANVAAACA MEME-4 Description -------------------------------------------------------------------------------- Simplified A 933979:8 pos.-specific C :23:3:9: probability G :33:::1: matrix T 1211:1:2 bits 3.0 2.7 2.4 * * * 2.1 * * * * Relative 1.8 * * * * Entropy 1.5 * *** * (12.6 bits) 1.2 * *** * 0.9 * ***** 0.6 * ***** 0.3 ** ***** 0.0 -------- Multilevel AAGAAACA consensus GA C T sequence TC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ANVAAACA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr3:193852856-193852936 38 5.59e-07 cgcggcggcA ATAAAACA TCCTGGCACG chr19:13162606-13162686 18 1.62e-06 CCAGGGGTTA AAGAAACA CAACCCGCCG chr17:49022042-49022122 55 3.69e-06 GCCCGCTGCG AACAAACA CCCCTCTGTG chr22:42229011-42229091 22 3.69e-06 TCCCATTGAC AACAAACA ggggggcgcg chr4:139592826-139592906 25 4.48e-06 TAAGAGATAG AGAAAACA TGGATGGGTG chr19:16369379-16369459 42 1.15e-05 GGCTATCGGC AGGAAACA TCTTGGCAGG chr2:64978627-64978707 11 1.84e-05 TCAGTCACGC AAATAACA GTGTGAgggc chr18:6683235-6683315 2 1.99e-05 C ACTAAACA GAACCTGACT chr7:91184354-91184434 19 2.22e-05 TCTTATCAGC ACGAAACA GCCTCTCCTA chr10:52086694-52086774 60 3.77e-05 AACTGCTTCC AACACACA TTTCCCCAGT chr19:45947641-45947721 42 3.77e-05 TTGCTGCGGC AAAACACT GGTCTCCAGG chr1:23884946-23885026 52 4.34e-05 GGCGCCAGGG AGGAAACT TGGTCTGTAC chr19:54372737-54372817 45 4.94e-05 CGGGGTTAAG ATCACACA CGCGCCCACG chr11:47198565-47198645 27 4.94e-05 CCGCGGCCGC AAGAATCA ACGCCGCGCC chr19:10613459-10613539 45 4.94e-05 CCGTGTCACA ATAAAAGT CCCCGGGCCC chr15:68177053-68177133 53 5.22e-05 GGAACATTCC AGCAAACT GAAGGCATcg chr7:5569517-5569597 20 6.29e-05 CTCCGCCCGG TTCAAACA GCGCCGGGTC chr18:46474969-46475049 3 6.80e-05 AA ACAAAAGA GGCCGCCTGG chr1:43871045-43871125 36 7.74e-05 AGGCTATCAC AAGACACT CCTTTTGGAG chr16:87086972-87087052 73 8.65e-05 CGCGCAGCAC AGGACACA chr19:907340-907420 67 9.49e-05 GACAGGGCCG ATAACAGA AGTGAC chr14:75743869-75743949 64 1.17e-04 GCTGTGTTGC TGTAAACA GCCGCTTCC chr7:135718301-135718381 6 1.23e-04 GTAAC ATTTAACT GCACTTTATC chr11:73727497-73727577 67 1.23e-04 GCCCAGGCCC AGGAATCA GAACAA chr1:92912291-92912371 33 1.66e-04 CTCAGCAGCC ACCACACA AGACCAGATT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ANVAAACA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr3:193852856-193852936 5.6e-07 37_[+4]_35 chr19:13162606-13162686 1.6e-06 17_[+4]_55 chr17:49022042-49022122 3.7e-06 54_[+4]_18 chr22:42229011-42229091 3.7e-06 21_[+4]_51 chr4:139592826-139592906 4.5e-06 24_[+4]_48 chr19:16369379-16369459 1.2e-05 41_[+4]_31 chr2:64978627-64978707 1.8e-05 10_[+4]_62 chr18:6683235-6683315 2e-05 1_[+4]_71 chr7:91184354-91184434 2.2e-05 18_[+4]_54 chr10:52086694-52086774 3.8e-05 59_[+4]_13 chr19:45947641-45947721 3.8e-05 41_[+4]_31 chr1:23884946-23885026 4.3e-05 51_[+4]_21 chr19:54372737-54372817 4.9e-05 44_[+4]_28 chr11:47198565-47198645 4.9e-05 26_[+4]_46 chr19:10613459-10613539 4.9e-05 44_[+4]_28 chr15:68177053-68177133 5.2e-05 52_[+4]_20 chr7:5569517-5569597 6.3e-05 19_[+4]_53 chr18:46474969-46475049 6.8e-05 2_[+4]_70 chr1:43871045-43871125 7.7e-05 35_[+4]_37 chr16:87086972-87087052 8.7e-05 72_[+4] chr19:907340-907420 9.5e-05 66_[+4]_6 chr14:75743869-75743949 0.00012 63_[+4]_9 chr7:135718301-135718381 0.00012 5_[+4]_67 chr11:73727497-73727577 0.00012 66_[+4]_6 chr1:92912291-92912371 0.00017 32_[+4]_40 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ANVAAACA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ANVAAACA width=8 seqs=25 chr3:193852856-193852936 ( 38) ATAAAACA 1 chr19:13162606-13162686 ( 18) AAGAAACA 1 chr17:49022042-49022122 ( 55) AACAAACA 1 chr22:42229011-42229091 ( 22) AACAAACA 1 chr4:139592826-139592906 ( 25) AGAAAACA 1 chr19:16369379-16369459 ( 42) AGGAAACA 1 chr2:64978627-64978707 ( 11) AAATAACA 1 chr18:6683235-6683315 ( 2) ACTAAACA 1 chr7:91184354-91184434 ( 19) ACGAAACA 1 chr10:52086694-52086774 ( 60) AACACACA 1 chr19:45947641-45947721 ( 42) AAAACACT 1 chr1:23884946-23885026 ( 52) AGGAAACT 1 chr19:54372737-54372817 ( 45) ATCACACA 1 chr11:47198565-47198645 ( 27) AAGAATCA 1 chr19:10613459-10613539 ( 45) ATAAAAGT 1 chr15:68177053-68177133 ( 53) AGCAAACT 1 chr7:5569517-5569597 ( 20) TTCAAACA 1 chr18:46474969-46475049 ( 3) ACAAAAGA 1 chr1:43871045-43871125 ( 36) AAGACACT 1 chr16:87086972-87087052 ( 73) AGGACACA 1 chr19:907340-907420 ( 67) ATAACAGA 1 chr14:75743869-75743949 ( 64) TGTAAACA 1 chr7:135718301-135718381 ( 6) ATTTAACT 1 chr11:73727497-73727577 ( 67) AGGAATCA 1 chr1:92912291-92912371 ( 33) ACCACACA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ANVAAACA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.1193 E= 6.4e-001 278 -1129 -1129 -63 125 -123 -39 96 106 -42 -20 -4 278 -1129 -1129 -63 242 -42 -1129 -1129 278 -1129 -1129 -63 -1129 123 -162 -1129 250 -1129 -1129 96 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ANVAAACA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 25 E= 6.4e-001 0.920000 0.000000 0.000000 0.080000 0.320000 0.160000 0.280000 0.240000 0.280000 0.280000 0.320000 0.120000 0.920000 0.000000 0.000000 0.080000 0.720000 0.280000 0.000000 0.000000 0.920000 0.000000 0.000000 0.080000 0.000000 0.880000 0.120000 0.000000 0.760000 0.000000 0.000000 0.240000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ANVAAACA MEME-4 regular expression -------------------------------------------------------------------------------- A[AGT][GAC]A[AC]AC[AT] -------------------------------------------------------------------------------- Time 16.72 secs. ******************************************************************************** ******************************************************************************** MOTIF TAMATAWT MEME-5 width = 8 sites = 4 llr = 51 E-value = 1.5e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif TAMATAWT MEME-5 Description -------------------------------------------------------------------------------- Simplified A :85a385: pos.-specific C ::5::::: probability G :::::::: matrix T a3::835a bits 3.0 * * * 2.7 * * * 2.4 * * * 2.1 ** *** * Relative 1.8 ** ***** Entropy 1.5 ** ***** (18.5 bits) 1.2 ******** 0.9 ******** 0.6 ******** 0.3 ******** 0.0 -------- Multilevel TAAATAAT consensus TC ATT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TAMATAWT MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:91184354-91184434 46 7.62e-08 AATGGCTTGA TAAATATT CCTGCCTCCC chr3:23987415-23987495 4 8.95e-07 CAT TACATAAT GGGCGCTGAG chr10:11643792-11643872 1 2.02e-06 . TACATTAT CTACGTGGAG chr8:106334003-106334083 50 2.40e-06 ATTATTACCA TTAAAATT CCAGCCCAGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TAMATAWT MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:91184354-91184434 7.6e-08 45_[+5]_27 chr3:23987415-23987495 8.9e-07 3_[+5]_69 chr10:11643792-11643872 2e-06 [+5]_72 chr8:106334003-106334083 2.4e-06 49_[+5]_23 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TAMATAWT MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TAMATAWT width=8 seqs=4 chr7:91184354-91184434 ( 46) TAAATATT 1 chr3:23987415-23987495 ( 4) TACATAAT 1 chr10:11643792-11643872 ( 1) TACATTAT 1 chr8:106334003-106334083 ( 50) TTAAAATT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TAMATAWT MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 12.8924 E= 1.5e+002 -865 -865 -865 301 248 -865 -865 101 190 42 -865 -865 290 -865 -865 -865 90 -865 -865 260 248 -865 -865 101 190 -865 -865 201 -865 -865 -865 301 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TAMATAWT MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 1.5e+002 0.000000 0.000000 0.000000 1.000000 0.750000 0.000000 0.000000 0.250000 0.500000 0.500000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.250000 0.000000 0.000000 0.750000 0.750000 0.000000 0.000000 0.250000 0.500000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TAMATAWT MEME-5 regular expression -------------------------------------------------------------------------------- T[AT][AC]A[TA][AT][AT]T -------------------------------------------------------------------------------- Time 20.37 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:1123173-1123253 6.03e-01 80 chr16:8962302-8962382 9.84e-01 80 chr3:170074716-170074796 9.98e-01 80 chr5:139088927-139089007 1.33e-03 60_[+1(4.26e-06)]_12 chr22:22863041-22863121 7.85e-01 80 chr14:65346688-65346768 3.03e-01 80 chr3:127795824-127795904 2.57e-01 80 chr19:13961361-13961441 8.26e-02 31_[+3(1.64e-05)]_41 chr17:42061349-42061429 1.99e-01 80 chr1:59281052-59281132 1.00e+00 80 chr14:50470138-50470218 5.78e-01 80 chr8:103666285-103666365 2.34e-02 80 chr14:75743869-75743949 1.29e-01 80 chr12:53268121-53268201 1.99e-02 30_[+3(9.31e-06)]_42 chr11:65189710-65189790 1.85e-01 80 chr8:145561958-145562038 5.37e-02 33_[+1(7.01e-06)]_39 chr2:8818980-8819060 2.08e-02 [+3(5.01e-05)]_72 chr1:209848512-209848592 9.88e-02 80 chr8:99956554-99956634 9.99e-01 80 chr2:128165692-128165772 5.18e-02 9_[+3(1.64e-05)]_4_[+3(2.85e-05)]_\ 51 chr1:59282062-59282142 9.49e-01 80 chr10:11653718-11653798 2.56e-01 80 chr19:18268035-18268115 4.31e-01 80 chr19:13162606-13162686 9.38e-04 17_[+4(1.62e-06)]_55 chr17:76254812-76254892 5.12e-02 66_[+2(2.11e-05)]_6 chr17:76356218-76356298 3.87e-05 30_[+3(6.30e-05)]_42 chr1:41826853-41826933 1.00e+00 80 chr19:40939915-40939995 1.00e+00 80 chr8:103819001-103819081 1.03e-01 42_[+3(2.85e-05)]_30 chrX:18372851-18372931 9.55e-01 80 chr2:145090062-145090142 1.00e+00 80 chr3:176915563-176915643 3.19e-06 16_[+5(2.82e-06)]_56 chr1:1850908-1850988 3.39e-01 80 chr9:114937561-114937641 2.84e-02 11_[+2(7.29e-06)]_61 chr5:141736717-141736797 9.87e-01 80 chr1:859211-859291 2.20e-01 80 chr2:242823864-242823944 5.34e-01 80 chr1:44495793-44495873 1.00e+00 80 chr2:10183524-10183604 2.98e-01 80 chr19:4328520-4328600 6.74e-01 80 chr2:17699748-17699828 6.52e-03 49_[+1(1.40e-05)]_23 chr19:18854226-18854306 2.75e-02 60_[+1(6.18e-05)]_12 chr6:44044393-44044473 9.44e-01 80 chr19:2169122-2169202 4.07e-01 80 chr19:10654375-10654455 2.22e-02 18_[+2(3.04e-05)]_31_[+2(9.13e-06)]_\ 15 chr11:65341814-65341894 1.68e-01 80 chr12:52430791-52430871 1.30e-02 32_[+1(1.84e-05)]_40 chr5:95066905-95066985 9.99e-01 80 chr19:39894597-39894677 3.34e-02 28_[+3(6.96e-06)]_44 chr12:94136121-94136201 4.46e-03 14_[+2(2.75e-06)]_58 chr12:8123378-8123458 8.80e-01 80 chr19:14628770-14628850 9.98e-01 80 chr2:200320549-200320629 8.89e-01 80 chr2:64872346-64872426 2.71e-01 80 chr6:43737832-43737912 8.95e-01 80 chr14:104625341-10462542 1.02e-03 48_[+2(1.90e-05)]_24 chr3:39195151-39195231 1.00e+00 80 chr9:132250905-132250985 7.17e-06 8_[+1(8.97e-05)]_36_[+3(1.73e-06)]_\ 20 chr8:106334003-106334083 1.45e-08 4_[+2(7.26e-07)]_5_[+2(7.80e-05)]_\ 15_[+1(5.21e-05)]_1_[+5(2.40e-06)]_23 chr9:115095265-115095345 3.02e-01 80 chr22:42229011-42229091 1.07e-02 21_[+4(3.69e-06)]_51 chr16:88522346-88522426 1.49e-05 40_[+2(5.59e-05)]_5_[+1(2.43e-07)]_\ 19 chrX:71238430-71238510 5.05e-03 67_[+3(6.96e-06)]_5 chr21:44394383-44394463 5.06e-02 80 chr5:141392586-141392666 9.89e-01 80 chr12:96793198-96793278 9.98e-01 80 chr15:95388161-95388241 4.51e-01 80 chr10:6205755-6205835 7.74e-01 80 chr11:34460179-34460259 1.35e-02 16_[+2(3.04e-05)]_56 chr7:105752767-105752847 8.59e-01 80 chr9:129987421-129987501 9.89e-01 80 chr3:5229261-5229341 1.00e+00 80 chr17:27503801-27503881 3.92e-02 80 chr1:45501464-45501544 5.58e-09 38_[+2(7.26e-07)]_12_[+1(2.69e-06)]_\ 14 chr16:85587084-85587164 9.99e-01 80 chr7:50237316-50237396 2.89e-04 12_[+3(1.73e-06)]_47_[+3(2.85e-05)]_\ 5 chr3:193852856-193852936 3.58e-05 37_[+4(5.59e-07)]_35 chr7:105925662-105925742 2.73e-01 80 chrX:40032040-40032120 1.48e-01 80 chr19:46272721-46272801 5.71e-01 80 chr17:49022042-49022122 6.18e-05 54_[+4(3.69e-06)]_18 chr19:40927215-40927295 7.27e-01 80 chr19:41129924-41130004 9.12e-01 80 chr12:4430148-4430228 4.52e-01 80 chr5:131831599-131831679 5.71e-01 80 chr15:66914590-66914670 2.82e-02 49_[+1(9.25e-06)]_23 chr1:159894404-159894484 1.09e-04 23_[+3(6.96e-06)]_49 chr18:77267146-77267226 3.93e-05 64_[+1(5.05e-07)]_8 chr17:37823910-37823990 1.32e-01 80 chr12:46765184-46765264 9.52e-03 60_[+3(9.31e-06)]_12 chr6:89791463-89791543 9.85e-01 80 chr18:46474969-46475049 7.42e-02 2_[+4(6.80e-05)]_70 chr14:74226941-74227021 3.20e-02 80 chr16:31117221-31117301 2.30e-01 80 chr1:6663054-6663134 7.17e-02 52_[+3(6.96e-06)]_20 chr6:157041203-157041283 2.21e-01 80 chr5:39425002-39425082 5.75e-04 42_[+2(5.99e-05)]_30 chr19:45947641-45947721 3.47e-02 41_[+4(3.77e-05)]_31 chr18:6683235-6683315 3.16e-03 1_[+4(1.99e-05)]_71 chr2:172963888-172963968 7.57e-02 35_[+3(6.96e-06)]_37 chr17:61819217-61819297 4.70e-02 80 chr19:41732168-41732248 9.98e-01 80 chr15:68177053-68177133 3.47e-02 20_[+4(9.49e-05)]_24_[+4(5.22e-05)]_\ 20 chr20:32319943-32320023 1.00e+00 80 chr10:30359156-30359236 3.49e-04 80 chr3:12994875-12994955 5.41e-06 32_[+2(3.04e-05)]_31_[+1(2.43e-07)]_\ 1 chr12:122235204-12223528 7.36e-01 80 chr16:69599768-69599848 1.00e+00 80 chr4:39699597-39699677 9.85e-01 80 chr1:43871045-43871125 1.25e-03 35_[+4(7.74e-05)]_37 chr1:245026524-245026604 8.47e-02 80 chr18:3013337-3013417 5.11e-01 80 chr7:106685007-106685087 9.05e-01 80 chr6:12009278-12009358 7.20e-01 80 chr11:76494266-76494346 9.77e-01 80 chr1:54955097-54955177 7.15e-01 80 chr20:30160931-30161011 9.96e-01 80 chr3:141765326-141765406 1.80e-05 36_[+2(3.42e-06)]_36 chr12:49628334-49628414 1.83e-01 80 chr8:145597637-145597717 9.39e-01 80 chr6:32163618-32163698 2.10e-01 80 chr2:171679681-171679761 1.81e-01 80 chr11:2800018-2800098 4.18e-01 80 chr13:115046891-11504697 9.45e-01 80 chr16:89043517-89043597 4.11e-01 80 chr19:10613459-10613539 2.89e-04 44_[+4(4.94e-05)]_28 chr1:23881353-23881433 3.04e-02 80 chr3:8671295-8671375 7.83e-04 24_[+3(1.64e-05)]_14_[+3(1.64e-05)]_\ 26 chr12:111806877-11180695 7.07e-01 80 chr1:27693031-27693111 9.97e-01 80 chr1:54954008-54954088 5.85e-01 80 chr18:12407836-12407916 9.83e-01 80 chr8:21917530-21917610 6.75e-01 80 chr11:3253146-3253226 4.36e-02 80 chr1:206730532-206730612 5.38e-01 80 chr6:31870080-31870160 7.73e-01 80 chr6:44041115-44041195 1.00e+00 80 chr6:37070496-37070576 8.05e-01 80 chr5:90676054-90676134 2.52e-01 80 chr6:44214128-44214208 1.10e-01 80 chr3:193720973-193721053 9.98e-01 80 chr2:43453725-43453805 4.80e-01 80 chr2:176866989-176867069 3.29e-02 1_[+2(9.75e-05)]_71 chr17:42402214-42402294 9.88e-01 80 chr6:119256293-119256373 6.84e-01 80 chr1:92912291-92912371 2.46e-07 49_[+1(2.43e-07)]_14_[+1(1.24e-06)]_\ 1 chr16:87086972-87087052 2.88e-03 72_[+4(8.65e-05)] chr5:133801606-133801686 2.39e-02 65_[+3(6.96e-06)]_7 chr5:90576432-90576512 7.78e-02 10_[+3(6.96e-06)]_62 chr19:16369379-16369459 5.02e-06 11_[+2(2.75e-06)]_22_[+4(1.15e-05)]_\ 31 chr6:34759797-34759877 7.63e-01 80 chr10:92980168-92980248 1.15e-05 12_[+2(3.88e-05)]_11_[+1(3.06e-05)]_\ 41 chr1:23884946-23885026 6.40e-02 51_[+4(4.34e-05)]_21 chr6:134496152-134496232 5.32e-01 80 chr1:29359597-29359677 6.03e-07 65_[+2(7.26e-07)]_7 chr16:85647048-85647128 4.62e-01 80 chr19:2273790-2273870 1.00e+00 80 chr7:102036782-102036862 1.08e-01 80 chr8:103666495-103666575 1.00e+00 80 chr7:149119524-149119604 8.68e-01 80 chr10:80733353-80733433 9.36e-01 80 chr11:70588861-70588941 6.31e-04 [+2(7.29e-06)]_72 chr4:139592826-139592906 4.60e-04 24_[+4(4.48e-06)]_48 chr17:27070962-27071042 3.76e-01 80 chr6:108880467-108880547 7.61e-02 80 chr7:5594686-5594766 6.53e-01 80 chr10:51572378-51572458 4.87e-01 80 chr4:39640634-39640714 4.56e-01 80 chr9:94662439-94662519 4.40e-03 16_[+2(2.75e-06)]_56 chr19:13273898-13273978 3.64e-01 80 chr15:66923458-66923538 7.01e-01 80 chr2:219260827-219260907 9.93e-01 80 chr3:23987415-23987495 1.26e-04 3_[+5(8.95e-07)]_69 chr9:114658879-114658959 1.39e-01 80 chr12:46777236-46777316 1.55e-02 67_[+3(9.31e-06)]_5 chr19:907340-907420 2.77e-03 66_[+4(9.49e-05)]_6 chr10:52086694-52086774 4.85e-06 4_[+1(2.12e-05)]_47_[+4(3.77e-05)]_\ 13 chr19:13030142-13030222 1.60e-01 80 chr16:67596140-67596220 9.98e-01 80 chr8:41655184-41655264 9.94e-01 80 chr19:45943226-45943306 3.03e-04 7_[+2(2.75e-06)]_65 chr10:11643792-11643872 4.83e-07 [+5(2.02e-06)]_36_[+1(3.72e-05)]_6_\ [+1(3.48e-06)]_14 chrX:48644361-48644441 1.16e-06 11_[+2(5.30e-06)]_2_[+1(9.25e-06)]_\ 51 chr1:30601976-30602056 8.78e-05 29_[+2(6.69e-05)]_43 chr19:18110552-18110632 2.53e-03 46_[+2(5.30e-06)]_26 chr20:361457-361537 8.72e-03 63_[+2(3.04e-05)]_9 chr20:60697208-60697288 6.82e-01 80 chr16:50875119-50875199 6.95e-07 1_[+1(8.97e-05)]_49_[+2(2.75e-06)]_\ 14 chr2:158732992-158733072 1.00e+00 80 chr1:225615953-225616033 6.14e-03 70_[+1(3.48e-06)]_2 chr3:156825743-156825823 2.70e-05 9_[+1(4.15e-05)]_63 chr9:119228579-119228659 1.43e-04 58_[+1(1.97e-06)]_14 chr5:131826589-131826669 8.55e-01 80 chr7:26241257-26241337 1.00e+00 80 chr19:45970853-45970933 6.41e-01 80 chr1:8763479-8763559 6.84e-01 80 chr11:65667960-65668040 9.90e-01 80 chr7:155089317-155089397 1.00e+00 80 chr19:10025456-10025536 1.94e-04 10_[+1(2.45e-05)]_62 chr17:36886360-36886440 9.97e-01 80 chr19:48825294-48825374 6.69e-01 80 chr19:13266453-13266533 8.73e-01 80 chr2:242786447-242786527 1.41e-01 80 chr1:40042513-40042593 9.87e-01 80 chr19:39340038-39340118 6.11e-01 80 chr11:73727497-73727577 3.48e-04 45_[+1(9.25e-06)]_27 chr15:67095638-67095718 4.47e-01 80 chr7:5569517-5569597 1.08e-01 19_[+4(6.29e-05)]_53 chr2:64978627-64978707 1.48e-05 [+3(6.30e-05)]_2_[+4(1.84e-05)]_62 chr17:35969505-35969585 4.83e-01 80 chr8:130951947-130952027 3.16e-01 80 chr3:93692680-93692760 9.41e-01 80 chr5:177540475-177540555 1.17e-01 44_[+3(2.15e-05)]_28 chr2:97523771-97523851 5.31e-01 80 chr7:56131925-56132005 9.70e-01 80 chr6:135502339-135502419 3.07e-02 80 chr1:94375082-94375162 5.04e-01 80 chr7:91184354-91184434 5.89e-09 10_[+1(5.81e-05)]_[+4(2.22e-05)]_19_\ [+5(7.62e-08)]_27 chr17:56429673-56429753 9.95e-01 80 chr4:125634030-125634110 8.63e-01 80 chr5:60704670-60704750 3.81e-01 80 chr2:85766864-85766944 9.73e-01 80 chr15:83316414-83316494 9.65e-01 80 chr18:9708186-9708266 7.34e-01 80 chr1:38999702-38999782 1.01e-06 29_[+1(1.30e-05)]_35_[+3(1.64e-05)] chr20:61425826-61425906 5.48e-01 80 chr6:33378152-33378232 6.92e-01 80 chrX:48641399-48641479 8.92e-05 14_[+1(9.25e-06)]_58 chr11:47198565-47198645 1.16e-02 26_[+4(4.94e-05)]_46 chr7:135718301-135718381 7.28e-05 1_[+5(9.36e-05)]_27_[+1(7.97e-05)]_\ 36 chr1:51701899-51701979 1.32e-01 80 chr1:26438195-26438275 9.89e-01 80 chr19:54372737-54372817 1.14e-03 44_[+4(4.94e-05)]_28 chr10:133795508-13379558 7.70e-01 80 chr8:141629171-141629251 4.63e-04 22_[+1(1.97e-06)]_50 chr2:191878968-191879048 3.01e-01 80 chr12:93964718-93964798 7.70e-01 80 chr11:34073746-34073826 8.00e-01 80 chr11:47574756-47574836 3.78e-01 80 chr17:27224616-27224696 5.47e-01 80 chr1:109102585-109102665 4.44e-01 80 chr11:65264992-65265072 6.12e-01 80 chr9:126122613-126122693 4.96e-05 19_[+2(7.26e-07)]_53 chr6:26172193-26172273 7.32e-02 80 chr7:149468927-149469007 9.99e-01 80 chr10:124894718-12489479 1.11e-02 38_[+2(1.57e-05)]_34 chr19:944255-944335 1.84e-02 13_[+1(7.01e-06)]_59 chrX:40943854-40943934 4.24e-01 80 chr21:46494171-46494251 7.19e-01 80 chr17:7146400-7146480 9.98e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n05.farnam.hpc.yale.internal ********************************************************************************