******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/CBX3.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr22:21332920-21333000 1.0000 80 chr2:38966829-38966909 1.0000 80 chr7:18301875-18301955 1.0000 80 chr4:187641253-187641333 1.0000 80 chr1:203064344-203064424 1.0000 80 chr4:95348099-95348179 1.0000 80 chr11:77526058-77526138 1.0000 80 chr11:57386950-57387030 1.0000 80 chr5:148648655-148648735 1.0000 80 chr6:125432546-125432626 1.0000 80 chr20:49038318-49038398 1.0000 80 chr1:222942697-222942777 1.0000 80 chr7:149163617-149163697 1.0000 80 chr5:154066245-154066325 1.0000 80 chr3:12906933-12907013 1.0000 80 chr1:55109554-55109634 1.0000 80 chr20:33784302-33784382 1.0000 80 chr5:125980997-125981077 1.0000 80 chrX:39909950-39910030 1.0000 80 chr11:333338-333418 1.0000 80 chr7:99536066-99536146 1.0000 80 chr9:134418657-134418737 1.0000 80 chr8:102768635-102768715 1.0000 80 chr10:76576948-76577028 1.0000 80 chr19:14204110-14204190 1.0000 80 chr2:146172894-146172974 1.0000 80 chr12:125249090-12524917 1.0000 80 chr9:138787219-138787299 1.0000 80 chr7:101490622-101490702 1.0000 80 chr1:54399997-54400077 1.0000 80 chr1:180557401-180557481 1.0000 80 chr2:145476068-145476148 1.0000 80 chr7:151008762-151008842 1.0000 80 chr8:130512900-130512980 1.0000 80 chr6:44027508-44027588 1.0000 80 chr15:93493004-93493084 1.0000 80 chr14:70107805-70107885 1.0000 80 chr1:11817281-11817361 1.0000 80 chr5:131641274-131641354 1.0000 80 chr6:107106485-107106565 1.0000 80 chr1:207051941-207052021 1.0000 80 chr2:6971533-6971613 1.0000 80 chr16:11312571-11312651 1.0000 80 chr1:92212433-92212513 1.0000 80 chr11:109949769-10994984 1.0000 80 chr15:82285008-82285088 1.0000 80 chr9:138921079-138921159 1.0000 80 chr10:50474070-50474150 1.0000 80 chr5:149155503-149155583 1.0000 80 chr3:169929636-169929716 1.0000 80 chr7:75272371-75272451 1.0000 80 chr7:77450482-77450562 1.0000 80 chr12:127661515-12766159 1.0000 80 chr7:29871482-29871562 1.0000 80 chr1:91344981-91345061 1.0000 80 chr19:55439851-55439931 1.0000 80 chr19:40531974-40532054 1.0000 80 chr1:168421736-168421816 1.0000 80 chr15:81288753-81288833 1.0000 80 chr5:121425393-121425473 1.0000 80 chr7:92418044-92418124 1.0000 80 chr7:2068519-2068599 1.0000 80 chr18:9975788-9975868 1.0000 80 chr7:97726479-97726559 1.0000 80 chr4:88164743-88164823 1.0000 80 chr1:227122260-227122340 1.0000 80 chr7:10798910-10798990 1.0000 80 chr8:144751381-144751461 1.0000 80 chr5:118593469-118593549 1.0000 80 chr6:118895571-118895651 1.0000 80 chr12:106676300-10667638 1.0000 80 chr5:37775136-37775216 1.0000 80 chr1:227530281-227530361 1.0000 80 chr6:159390345-159390425 1.0000 80 chr2:112734953-112735033 1.0000 80 chr10:1024902-1024982 1.0000 80 chr3:136404904-136404984 1.0000 80 chr9:130288231-130288311 1.0000 80 chr1:196504985-196505065 1.0000 80 chr1:197694356-197694436 1.0000 80 chr6:132244668-132244748 1.0000 80 chr20:36871392-36871472 1.0000 80 chr11:17393326-17393406 1.0000 80 chr12:1856935-1857015 1.0000 80 chr1:53008104-53008184 1.0000 80 chr2:169772283-169772363 1.0000 80 chr7:106664110-106664190 1.0000 80 chr8:145838892-145838972 1.0000 80 chr8:127288166-127288246 1.0000 80 chr11:93708073-93708153 1.0000 80 chr6:34526126-34526206 1.0000 80 chr5:148990496-148990576 1.0000 80 chr5:173019233-173019313 1.0000 80 chr1:162446571-162446651 1.0000 80 chr6:43424688-43424768 1.0000 80 chr7:103054040-103054120 1.0000 80 chr7:5134452-5134532 1.0000 80 chr6:159326497-159326577 1.0000 80 chr3:157918933-157919013 1.0000 80 chr6:90996755-90996835 1.0000 80 chr1:117286288-117286368 1.0000 80 chr20:726503-726583 1.0000 80 chr9:101127645-101127725 1.0000 80 chr2:241471621-241471701 1.0000 80 chr9:135572835-135572915 1.0000 80 chr6:108563629-108563709 1.0000 80 chr9:132275702-132275782 1.0000 80 chr20:32535674-32535754 1.0000 80 chr11:87049232-87049312 1.0000 80 chr3:10287144-10287224 1.0000 80 chr6:27282015-27282095 1.0000 80 chr7:65730743-65730823 1.0000 80 chr1:244739732-244739812 1.0000 80 chr10:71309916-71309996 1.0000 80 chr8:23457940-23458020 1.0000 80 chr1:236545011-236545091 1.0000 80 chr2:113758157-113758237 1.0000 80 chr8:91151332-91151412 1.0000 80 chr21:31032850-31032930 1.0000 80 chr17:37203401-37203481 1.0000 80 chr10:5561157-5561237 1.0000 80 chr1:234821938-234822018 1.0000 80 chr12:117001223-11700130 1.0000 80 chr3:14946698-14946778 1.0000 80 chr2:127433348-127433428 1.0000 80 chr3:33740953-33741033 1.0000 80 chr3:150393500-150393580 1.0000 80 chr19:8917505-8917585 1.0000 80 chr7:86957778-86957858 1.0000 80 chr6:149419971-149420051 1.0000 80 chr5:10740671-10740751 1.0000 80 chr6:163929139-163929219 1.0000 80 chr7:35731732-35731812 1.0000 80 chr21:34739916-34739996 1.0000 80 chr7:158500394-158500474 1.0000 80 chr18:77782809-77782889 1.0000 80 chr14:100621486-10062156 1.0000 80 chr1:114389411-114389491 1.0000 80 chr1:155613161-155613241 1.0000 80 chr11:61766908-61766988 1.0000 80 chr7:156526559-156526639 1.0000 80 chr7:138114449-138114529 1.0000 80 chr2:28378655-28378735 1.0000 80 chr1:53603581-53603661 1.0000 80 chr4:123410359-123410439 1.0000 80 chr11:59936920-59937000 1.0000 80 chr2:109486664-109486744 1.0000 80 chr5:134318134-134318214 1.0000 80 chr6:157927071-157927151 1.0000 80 chr7:66717092-66717172 1.0000 80 chr12:132678763-13267884 1.0000 80 chr17:59697066-59697146 1.0000 80 chr1:224359011-224359091 1.0000 80 chr2:97043201-97043281 1.0000 80 chr8:145143362-145143442 1.0000 80 chr1:26697614-26697694 1.0000 80 chr22:50161046-50161126 1.0000 80 chr9:130285826-130285906 1.0000 80 chr6:170792674-170792754 1.0000 80 chr1:167946639-167946719 1.0000 80 chr21:46248722-46248802 1.0000 80 chr6:150087455-150087535 1.0000 80 chr6:24431420-24431500 1.0000 80 chr7:774012-774092 1.0000 80 chr20:62776966-62777046 1.0000 80 chr2:43096165-43096245 1.0000 80 chr7:64869085-64869165 1.0000 80 chr6:13942342-13942422 1.0000 80 chr2:174163436-174163516 1.0000 80 chr9:132064367-132064447 1.0000 80 chr10:72408397-72408477 1.0000 80 chr22:19254231-19254311 1.0000 80 chr12:51193893-51193973 1.0000 80 chr3:5490660-5490740 1.0000 80 chr16:58394126-58394206 1.0000 80 chr11:76487668-76487748 1.0000 80 chr16:30108409-30108489 1.0000 80 chr7:155441546-155441626 1.0000 80 chr8:103689464-103689544 1.0000 80 chr17:75163948-75164028 1.0000 80 chr4:123964316-123964396 1.0000 80 chr16:85386795-85386875 1.0000 80 chr9:90282251-90282331 1.0000 80 chr5:147978971-147979051 1.0000 80 chr8:42344138-42344218 1.0000 80 chr6:39139433-39139513 1.0000 80 chr9:126590945-126591025 1.0000 80 chr7:50286328-50286408 1.0000 80 chr1:224531442-224531522 1.0000 80 chr1:154268239-154268319 1.0000 80 chr7:2064961-2065041 1.0000 80 chr21:38774710-38774790 1.0000 80 chr1:212032893-212032973 1.0000 80 chr3:45132475-45132555 1.0000 80 chr10:29134084-29134164 1.0000 80 chr20:48162253-48162333 1.0000 80 chr7:149408057-149408137 1.0000 80 chr3:72274071-72274151 1.0000 80 chr6:157346782-157346862 1.0000 80 chr16:50705723-50705803 1.0000 80 chr1:117437857-117437937 1.0000 80 chr10:5207848-5207928 1.0000 80 chr3:196710224-196710304 1.0000 80 chr10:75077154-75077234 1.0000 80 chr7:12741181-12741261 1.0000 80 chr4:83945533-83945613 1.0000 80 chr6:158379240-158379320 1.0000 80 chr5:79016119-79016199 1.0000 80 chr1:52682731-52682811 1.0000 80 chr1:11566126-11566206 1.0000 80 chr3:158453234-158453314 1.0000 80 chr1:26595781-26595861 1.0000 80 chr22:25112731-25112811 1.0000 80 chr20:40228636-40228716 1.0000 80 chr12:111742523-11174260 1.0000 80 chr1:12447901-12447981 1.0000 80 chr11:70597404-70597484 1.0000 80 chr13:41722987-41723067 1.0000 80 chr2:158579286-158579366 1.0000 80 chr4:56441845-56441925 1.0000 80 chr2:112962144-112962224 1.0000 80 chr21:46242948-46243028 1.0000 80 chr4:2134334-2134414 1.0000 80 chr11:74588374-74588454 1.0000 80 chr11:69239647-69239727 1.0000 80 chr7:138054719-138054799 1.0000 80 chr7:127835068-127835148 1.0000 80 chr2:44537575-44537655 1.0000 80 chr7:106677142-106677222 1.0000 80 chr16:11301656-11301736 1.0000 80 chr17:75170840-75170920 1.0000 80 chr2:25117756-25117836 1.0000 80 chr8:8293290-8293370 1.0000 80 chr12:94816061-94816141 1.0000 80 chr1:117291116-117291196 1.0000 80 chr19:5515887-5515967 1.0000 80 chr19:970803-970883 1.0000 80 chr12:96738210-96738290 1.0000 80 chr19:8134385-8134465 1.0000 80 chr7:131021797-131021877 1.0000 80 chr1:68429111-68429191 1.0000 80 chr5:452335-452415 1.0000 80 chr19:6292188-6292268 1.0000 80 chr2:6985643-6985723 1.0000 80 chr2:172386597-172386677 1.0000 80 chr10:72139479-72139559 1.0000 80 chr1:200948903-200948983 1.0000 80 chr7:75436042-75436122 1.0000 80 chr2:24643414-24643494 1.0000 80 chr19:3467910-3467990 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_CBX3/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/CBX3.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.282 C 0.214 G 0.222 T 0.282 Background letter frequencies (from file dataset with add-one prior applied): A 0.282 C 0.214 G 0.222 T 0.282 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TCWGCWGA MEME-1 width = 8 sites = 134 llr = 973 E-value = 9.9e-076 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCWGCWGA MEME-1 Description -------------------------------------------------------------------------------- Simplified A 2:5:15:6 pos.-specific C :a::9::: probability G 1::9::a: matrix T 7:51:5:3 bits 2.2 * * 2.0 * * 1.8 * * 1.6 * ** * Relative 1.3 * ** * Entropy 1.1 * ** * (10.5 bits) 0.9 ****** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TCAGCAGA consensus A T T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWGCWGA MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr4:56441845-56441925 50 1.43e-05 agccagtttc tcagcaga aattttggaa chr1:68429111-68429191 40 4.28e-05 aatctttatt tctgcaga aagggtgctc chr1:117291116-117291196 16 4.28e-05 gcagcaccca tctgcaga agtaaatgtg chr12:94816061-94816141 45 4.28e-05 tggcaccctt tctgcaga aagtaaatta chr20:40228636-40228716 30 4.28e-05 gcagcaccat tctgcaga agtaaatgtg chr22:25112731-25112811 18 4.28e-05 gagcactgtt tctgcaga aaataaaaac chr1:26595781-26595861 31 4.28e-05 gagcaccctt tctgcaga aagtaaaaat chr1:52682731-52682811 40 4.28e-05 cacttttact tctgcaga agggtgctgc chr17:75163948-75164028 37 4.28e-05 gcaatttact tctgcaga aaggtgctgc chr16:30108409-30108489 35 4.28e-05 gcagcaccct tctgcaga agtaaagatg chr8:145143362-145143442 42 4.28e-05 aattttactt tctgcaga aagggtgctc chr7:66717092-66717172 29 4.28e-05 gcagtttact tctgcaga agggtgctgc chr7:138114449-138114529 46 4.28e-05 caaatttact tctgcaga agggtgctgc chr21:34739916-34739996 18 4.28e-05 gcagcactct tctgcaga agtaaatgtg chr17:37203401-37203481 27 4.28e-05 aagcaccctt tctgcaga aagtaaattt chr1:244739732-244739812 14 4.28e-05 aattttactt tctgcaga aagggtgctc chr3:10287144-10287224 39 4.28e-05 gtgtaccctt tctgcaga aagtgtaaaa chr6:118895571-118895651 24 4.28e-05 gcaccaccct tctgcaga agtaaattgc chr8:144751381-144751461 42 4.28e-05 caaatttact tctgcaga agagtgccgc chr7:10798910-10798990 52 4.28e-05 caaatttact tctgcaga agggcaccgc chr9:138921079-138921159 61 4.28e-05 gggtctcctc tcagctga gagctgagca chr15:93493004-93493084 39 4.28e-05 aattttactt tctgcaga aagggtgctt chr1:180557401-180557481 45 4.28e-05 ggacaccctt tctgcaga aagtaaaaat chr5:125980997-125981077 29 4.28e-05 tgccactgtt tcagctga aaagtcaact chr3:12906933-12907013 24 4.28e-05 gtgacaccct tctgcaga agtaaattgc chr3:196710224-196710304 19 5.71e-05 ttctgttgtg tctgctga gaagttggct chr11:76487668-76487748 39 5.71e-05 tgatgagaaa tctgctga cagtcttatt chr1:227530281-227530361 39 5.71e-05 ACAGACACAG TCTGCTGA ATCTCCTTCC chr6:125432546-125432626 22 5.71e-05 tgctaagaaa tctgctga tagtctcatg chr5:147978971-147979051 32 7.14e-05 atctgacttt tcagcagt aagtatggaa chr4:123964316-123964396 59 7.14e-05 tgataagaag tcagcagt agttctttgc chr7:127835068-127835148 29 9.99e-05 ttatgggaag tcagctgt cacttgtagt chr7:12741181-12741261 31 9.99e-05 tgttgggagg tcagctgt tggtctaatt chr3:72274071-72274151 31 9.99e-05 tggtggaaag tcagctgt taatcttatt chr1:224531442-224531522 41 9.99e-05 tgatgagaaa tcagctgt taatcttatt chr8:42344138-42344218 43 9.99e-05 ctgatggaag tcagctgt ccatcttact chr3:5490660-5490740 30 9.99e-05 cttgttttgg tcagctgt tattctcacc chr11:61766908-61766988 26 9.99e-05 cagcaccttt tctgcagt aagtaaaatt chr8:23457940-23458020 48 9.99e-05 ggatgagaaa tctgcagt catctgaatt chr9:132275702-132275782 40 9.99e-05 ctatgagaag tctgcagt cttttgcagc chr6:43424688-43424768 52 9.99e-05 TGGCCTCCTC TCAGCTGT GATCGCCTCT chr5:148990496-148990576 48 9.99e-05 ccctcaaata tctgcagt cacctgcagg chr10:1024902-1024982 35 9.99e-05 tgttgagcag tcagctgt cacactcact chr6:159390345-159390425 57 9.99e-05 ggatgagaag tcagctgt taatgttatt chr7:97726479-97726559 54 9.99e-05 tgatgaaaag tcagctgt taatctcatt chr18:9975788-9975868 50 9.99e-05 ctatgaatag tcagctgt cagtttattt chr19:40531974-40532054 19 9.99e-05 ggataagaag tcagctgt caatcgattg chr1:91344981-91345061 35 9.99e-05 tgaggataaa tcagctgt taatcttata chr1:54399997-54400077 46 9.99e-05 tgatgtaaag tcagctgt cattagcact chr7:99536066-99536146 50 9.99e-05 tgaggagata tcagctgt taaacttatt chr2:25117756-25117836 66 1.28e-04 tgaccacaca tctgctgt cattctt chr7:149408057-149408137 32 1.28e-04 aattagactg acagcaga cttttcaata chr2:109486664-109486744 33 1.28e-04 gaagagttca acagcaga cttgaacagg chr1:114389411-114389491 26 1.28e-04 taatgcaaaa tctgctgt cattctaatt chr3:14946698-14946778 44 1.28e-04 tggtggaaag tctgctgt gatactcatg chr1:236545011-236545091 27 1.28e-04 tgatgaaaaa tctgctgt catccttgtt chr10:71309916-71309996 44 1.28e-04 gataacaatg acagcaga ctactcatca chr7:65730743-65730823 36 1.28e-04 agtaagatga acagcaga cttctcacca chr20:726503-726583 24 1.28e-04 aataagaccg acagcaga tttctcatgt chr6:159326497-159326577 34 1.28e-04 agtaagatta acagcaga tttctcaaca chr8:145838892-145838972 61 1.28e-04 tcatgagaaa tctgctgt catctgtgtc chr1:197694356-197694436 34 1.28e-04 tattacatcg acagcaga cttctcaata chr19:55439851-55439931 19 1.28e-04 GTTTTTAGTG ACAGCAGA CATCTCGATA chr15:82285008-82285088 38 1.28e-04 aattgcacca acagcaga actgatcaag chr2:6971533-6971613 37 1.28e-04 ccagaagggg acagcaga tttcccatca chr1:207051941-207052021 40 1.28e-04 aaactctttc tctgctgt aatatcactg chr14:70107805-70107885 27 1.28e-04 tgacactgaa tctgctgt aattctttgc chr9:134418657-134418737 48 1.28e-04 aaacgagatg tctgctgt aattcTTCtc chr12:96738210-96738290 61 1.57e-04 agtaagatta acagctga tgtgtcatca chr4:2134334-2134414 35 1.57e-04 aatgtgagtg actgcaga tttcctgtca chr11:70597404-70597484 28 1.57e-04 cacaggaatt actgcaga ttcctcatca chr7:50286328-50286408 29 1.57e-04 aattccactg acagctga ctttgcaaca chr7:158500394-158500474 55 1.57e-04 aaggcagaga acagctga ccaaatagct chr11:87049232-87049312 38 1.57e-04 tccaagatta acagctga cttcctagca chr6:108563629-108563709 37 1.57e-04 aataagatta acagctga cttctcacca chr2:241471621-241471701 10 1.57e-04 aataggctg acagctga cttctcaaca chr7:18301875-18301955 32 1.57e-04 aataaggctg acagctga tttctcttca chr2:38966829-38966909 40 1.57e-04 agtacaatta acagctga cttctcatct chr2:112962144-112962224 44 2.51e-04 aggtcacttc tcatcaga aactatggaa chr12:51193893-51193973 51 2.51e-04 tacagagtgc tcatcaga aactatggag chr17:59697066-59697146 70 2.51e-04 acaatggaag tcagaaga caa chr8:127288166-127288246 38 2.51e-04 tttatggaag tcagaaga taatgggaca chr5:118593469-118593549 18 2.51e-04 attatgcaag tcagaaga caatggaaca chr7:92418044-92418124 46 2.51e-04 caactacttc tcatcaga aactatggag chr3:169929636-169929716 42 2.51e-04 agctgacttc tcatcaga aacattggag chr20:33784302-33784382 33 2.51e-04 tgtagatttt tcatcaga gaccatggaa chr1:200948903-200948983 72 3.50e-04 GAGCTCCAGG TCTGAAGA G chr7:138054719-138054799 67 3.50e-04 ctttatctgg gcagcaga caagga chr2:158579286-158579366 42 3.50e-04 aataagaatg gcagcaga tttctcacag chr10:75077154-75077234 16 3.50e-04 ttccattgtt tcagatga aaaatcagtg chr10:29134084-29134164 50 3.50e-04 agcaggcttt gcagcaga gagagggttt chr1:154268239-154268319 55 3.50e-04 ggcagacttc tcttcaga aacaatggag chr2:97043201-97043281 27 3.50e-04 ttccatagtt tctgaaga aaggtaggca chr12:132678763-13267884 62 3.50e-04 acaccgtgtg gcagcaga tgcaaaggca chr8:91151332-91151412 37 3.50e-04 atataagatg gcagcaga tttctaatca chr7:106664110-106664190 69 3.50e-04 agtccagctt tcagatga acac chr9:138787219-138787299 15 3.50e-04 caaagacttc tcatctga agctatggag chr1:55109554-55109634 27 3.50e-04 ctccatagtt tcagatga gaaatatgct chr8:8293290-8293370 10 4.10e-04 gttccactg tcttctga cttccattgt chr7:106677142-106677222 65 4.10e-04 tgttgaggag tctgatga tgttctga chr1:11566126-11566206 16 4.10e-04 cactccattg tcttctga cttccatcat chr6:158379240-158379320 36 4.10e-04 ttgcatagtt tctgatga caaatctgcc chr7:155441546-155441626 2 4.10e-04 t tctgatga gaaattgact chr9:132064367-132064447 40 4.10e-04 ctccataatt tctgatga aaagtcagtg chr1:26697614-26697694 66 4.10e-04 GACAGAGAAG GCAGCTGA TCTCACA chr3:157918933-157919013 37 4.10e-04 cattccactg tcttctga tttccattat chr1:11817281-11817361 38 4.10e-04 acaattactg gcagctga tgtctcaaca chr7:149163617-149163697 41 4.10e-04 tagtccattg tcttctga cttccatgtt chr7:86957778-86957858 54 4.43e-04 gaggagctag tcagcagg agtagccatg chr7:101490622-101490702 39 4.43e-04 CTGATCCCTA TCAGCAGC CATGCGTCCC chr12:1856935-1857015 13 4.87e-04 tgcttagaag tcagctgc taatcttact chr7:75272371-75272451 38 4.87e-04 GAGTCGAGAT TCTGCAGC CTAGCCCTAA chr21:31032850-31032930 47 5.09e-04 ACATAATTGG TCTGCTGC TACTATTGTG chr7:77450482-77450562 6 5.09e-04 cattc tctgctgg cctgtaaggc chr22:21332920-21333000 35 5.09e-04 CACCTGAGGG TCTGCTGC TTGAAACCCC chr6:157346782-157346862 57 5.46e-04 gtttatccac tcatcagt tgaagggtat chr10:76576948-76577028 7 5.46e-04 TTCATG TCatcagt tgcaattcag chr2:24643414-24643494 15 6.31e-04 tcatttttca tcttcagt tgctttgtca chr19:8917505-8917585 1 6.31e-04 . tcagatgt cattcattgt chr3:33740953-33741033 37 7.28e-04 atacacaagt acagaaga tttccggcca chr12:117001223-11700130 21 7.28e-04 tattccattg tcttctgt gttgcattgt chr6:27282015-27282095 5 7.28e-04 actt acagaaga accctaaaca chr11:93708073-93708153 52 7.28e-04 tggtgagaag tctgatgt tagtctgatt chr19:5515887-5515967 3 8.13e-04 ag gctgctgt tatttctgtg chr7:156526559-156526639 26 8.13e-04 gataagtatg acagatga cttgttggaa chr3:150393500-150393580 12 8.13e-04 tttttaccac actgaaga cattccattg chr11:77526058-77526138 37 8.13e-04 AGGTGGTGTG ACTTCAGA CATGAGGATC chr1:203064344-203064424 8 8.50e-04 taggaaa actgatga tttcccatca chr9:126590945-126591025 37 8.61e-04 agatgacttt ccagcaga aacaatgtaa chr14:100621486-10062156 65 9.15e-04 cctggtggcc acagcagg aaatgctt chr1:196504985-196505065 58 9.15e-04 gcactccaaa cctgctga gtcacactgt chr9:130288231-130288311 14 9.15e-04 AATAGCTCAT ACAGCAGG GCTACCATGC chr3:136404904-136404984 49 9.15e-04 ccttaagatt acagcagg ttgttttggc chr1:167946639-167946719 48 1.02e-03 gcaaagtcag acatcagt ctaattgtgg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWGCWGA MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:56441845-56441925 1.4e-05 49_[+1]_23 chr1:68429111-68429191 4.3e-05 39_[+1]_33 chr1:117291116-117291196 4.3e-05 15_[+1]_57 chr12:94816061-94816141 4.3e-05 44_[+1]_28 chr20:40228636-40228716 4.3e-05 29_[+1]_43 chr22:25112731-25112811 4.3e-05 17_[+1]_55 chr1:26595781-26595861 4.3e-05 30_[+1]_42 chr1:52682731-52682811 4.3e-05 39_[+1]_33 chr17:75163948-75164028 4.3e-05 36_[+1]_36 chr16:30108409-30108489 4.3e-05 34_[+1]_38 chr8:145143362-145143442 4.3e-05 41_[+1]_31 chr7:66717092-66717172 4.3e-05 28_[+1]_44 chr7:138114449-138114529 4.3e-05 45_[+1]_27 chr21:34739916-34739996 4.3e-05 17_[+1]_55 chr17:37203401-37203481 4.3e-05 26_[+1]_46 chr1:244739732-244739812 4.3e-05 13_[+1]_59 chr3:10287144-10287224 4.3e-05 38_[+1]_34 chr6:118895571-118895651 4.3e-05 23_[+1]_49 chr8:144751381-144751461 4.3e-05 41_[+1]_31 chr7:10798910-10798990 4.3e-05 51_[+1]_21 chr9:138921079-138921159 4.3e-05 60_[+1]_12 chr15:93493004-93493084 4.3e-05 38_[+1]_34 chr1:180557401-180557481 4.3e-05 44_[+1]_28 chr5:125980997-125981077 4.3e-05 28_[+1]_44 chr3:12906933-12907013 4.3e-05 23_[+1]_49 chr3:196710224-196710304 5.7e-05 18_[+1]_54 chr11:76487668-76487748 5.7e-05 38_[+1]_34 chr1:227530281-227530361 5.7e-05 38_[+1]_34 chr6:125432546-125432626 5.7e-05 21_[+1]_51 chr5:147978971-147979051 7.1e-05 31_[+1]_41 chr4:123964316-123964396 7.1e-05 58_[+1]_14 chr7:127835068-127835148 0.0001 28_[+1]_44 chr7:12741181-12741261 0.0001 30_[+1]_42 chr3:72274071-72274151 0.0001 30_[+1]_42 chr1:224531442-224531522 0.0001 40_[+1]_32 chr8:42344138-42344218 0.0001 42_[+1]_30 chr3:5490660-5490740 0.0001 29_[+1]_43 chr11:61766908-61766988 0.0001 25_[+1]_47 chr8:23457940-23458020 0.0001 47_[+1]_25 chr9:132275702-132275782 0.0001 39_[+1]_33 chr6:43424688-43424768 0.0001 51_[+1]_21 chr5:148990496-148990576 0.0001 47_[+1]_25 chr10:1024902-1024982 0.0001 34_[+1]_38 chr6:159390345-159390425 0.0001 56_[+1]_16 chr7:97726479-97726559 0.0001 53_[+1]_19 chr18:9975788-9975868 0.0001 49_[+1]_23 chr19:40531974-40532054 0.0001 18_[+1]_54 chr1:91344981-91345061 0.0001 34_[+1]_38 chr1:54399997-54400077 0.0001 45_[+1]_27 chr7:99536066-99536146 0.0001 49_[+1]_23 chr2:25117756-25117836 0.00013 65_[+1]_7 chr7:149408057-149408137 0.00013 31_[+1]_41 chr2:109486664-109486744 0.00013 32_[+1]_40 chr1:114389411-114389491 0.00013 25_[+1]_47 chr3:14946698-14946778 0.00013 43_[+1]_29 chr1:236545011-236545091 0.00013 26_[+1]_46 chr10:71309916-71309996 0.00013 43_[+1]_29 chr7:65730743-65730823 0.00013 35_[+1]_37 chr20:726503-726583 0.00013 23_[+1]_49 chr6:159326497-159326577 0.00013 33_[+1]_39 chr8:145838892-145838972 0.00013 60_[+1]_12 chr1:197694356-197694436 0.00013 33_[+1]_39 chr19:55439851-55439931 0.00013 18_[+1]_54 chr15:82285008-82285088 0.00013 37_[+1]_35 chr2:6971533-6971613 0.00013 36_[+1]_36 chr1:207051941-207052021 0.00013 39_[+1]_33 chr14:70107805-70107885 0.00013 26_[+1]_46 chr9:134418657-134418737 0.00013 47_[+1]_25 chr12:96738210-96738290 0.00016 60_[+1]_12 chr4:2134334-2134414 0.00016 34_[+1]_38 chr11:70597404-70597484 0.00016 27_[+1]_45 chr7:50286328-50286408 0.00016 28_[+1]_44 chr7:158500394-158500474 0.00016 54_[+1]_18 chr11:87049232-87049312 0.00016 37_[+1]_35 chr6:108563629-108563709 0.00016 36_[+1]_36 chr2:241471621-241471701 0.00016 9_[+1]_63 chr7:18301875-18301955 0.00016 31_[+1]_41 chr2:38966829-38966909 0.00016 39_[+1]_33 chr2:112962144-112962224 0.00025 43_[+1]_29 chr12:51193893-51193973 0.00025 50_[+1]_22 chr17:59697066-59697146 0.00025 69_[+1]_3 chr8:127288166-127288246 0.00025 37_[+1]_35 chr5:118593469-118593549 0.00025 17_[+1]_55 chr7:92418044-92418124 0.00025 45_[+1]_27 chr3:169929636-169929716 0.00025 41_[+1]_31 chr20:33784302-33784382 0.00025 32_[+1]_40 chr1:200948903-200948983 0.00035 71_[+1]_1 chr7:138054719-138054799 0.00035 66_[+1]_6 chr2:158579286-158579366 0.00035 41_[+1]_31 chr10:75077154-75077234 0.00035 15_[+1]_57 chr10:29134084-29134164 0.00035 49_[+1]_23 chr1:154268239-154268319 0.00035 54_[+1]_18 chr2:97043201-97043281 0.00035 26_[+1]_46 chr12:132678763-13267884 0.00035 61_[+1]_11 chr8:91151332-91151412 0.00035 36_[+1]_36 chr7:106664110-106664190 0.00035 68_[+1]_4 chr9:138787219-138787299 0.00035 14_[+1]_58 chr1:55109554-55109634 0.00035 26_[+1]_46 chr8:8293290-8293370 0.00041 9_[+1]_63 chr7:106677142-106677222 0.00041 64_[+1]_8 chr1:11566126-11566206 0.00041 15_[+1]_57 chr6:158379240-158379320 0.00041 35_[+1]_37 chr7:155441546-155441626 0.00041 1_[+1]_71 chr9:132064367-132064447 0.00041 39_[+1]_33 chr1:26697614-26697694 0.00041 65_[+1]_7 chr3:157918933-157919013 0.00041 36_[+1]_36 chr1:11817281-11817361 0.00041 37_[+1]_35 chr7:149163617-149163697 0.00041 40_[+1]_32 chr7:86957778-86957858 0.00044 53_[+1]_19 chr7:101490622-101490702 0.00044 38_[+1]_34 chr12:1856935-1857015 0.00049 12_[+1]_60 chr7:75272371-75272451 0.00049 37_[+1]_35 chr21:31032850-31032930 0.00051 46_[+1]_26 chr7:77450482-77450562 0.00051 5_[+1]_67 chr22:21332920-21333000 0.00051 34_[+1]_38 chr6:157346782-157346862 0.00055 56_[+1]_16 chr10:76576948-76577028 0.00055 6_[+1]_66 chr2:24643414-24643494 0.00063 14_[+1]_58 chr19:8917505-8917585 0.00063 [+1]_72 chr3:33740953-33741033 0.00073 36_[+1]_36 chr12:117001223-11700130 0.00073 20_[+1]_52 chr6:27282015-27282095 0.00073 4_[+1]_68 chr11:93708073-93708153 0.00073 51_[+1]_21 chr19:5515887-5515967 0.00081 2_[+1]_70 chr7:156526559-156526639 0.00081 25_[+1]_47 chr3:150393500-150393580 0.00081 11_[+1]_61 chr11:77526058-77526138 0.00081 36_[+1]_36 chr1:203064344-203064424 0.00085 7_[+1]_65 chr9:126590945-126591025 0.00086 36_[+1]_36 chr14:100621486-10062156 0.00092 64_[+1]_8 chr1:196504985-196505065 0.00092 57_[+1]_15 chr9:130288231-130288311 0.00092 13_[+1]_59 chr3:136404904-136404984 0.00092 48_[+1]_24 chr1:167946639-167946719 0.001 47_[+1]_25 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWGCWGA MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCWGCWGA width=8 seqs=134 chr4:56441845-56441925 ( 50) TCAGCAGA 1 chr1:68429111-68429191 ( 40) TCTGCAGA 1 chr1:117291116-117291196 ( 16) TCTGCAGA 1 chr12:94816061-94816141 ( 45) TCTGCAGA 1 chr20:40228636-40228716 ( 30) TCTGCAGA 1 chr22:25112731-25112811 ( 18) TCTGCAGA 1 chr1:26595781-26595861 ( 31) TCTGCAGA 1 chr1:52682731-52682811 ( 40) TCTGCAGA 1 chr17:75163948-75164028 ( 37) TCTGCAGA 1 chr16:30108409-30108489 ( 35) TCTGCAGA 1 chr8:145143362-145143442 ( 42) TCTGCAGA 1 chr7:66717092-66717172 ( 29) TCTGCAGA 1 chr7:138114449-138114529 ( 46) TCTGCAGA 1 chr21:34739916-34739996 ( 18) TCTGCAGA 1 chr17:37203401-37203481 ( 27) TCTGCAGA 1 chr1:244739732-244739812 ( 14) TCTGCAGA 1 chr3:10287144-10287224 ( 39) TCTGCAGA 1 chr6:118895571-118895651 ( 24) TCTGCAGA 1 chr8:144751381-144751461 ( 42) TCTGCAGA 1 chr7:10798910-10798990 ( 52) TCTGCAGA 1 chr9:138921079-138921159 ( 61) TCAGCTGA 1 chr15:93493004-93493084 ( 39) TCTGCAGA 1 chr1:180557401-180557481 ( 45) TCTGCAGA 1 chr5:125980997-125981077 ( 29) TCAGCTGA 1 chr3:12906933-12907013 ( 24) TCTGCAGA 1 chr3:196710224-196710304 ( 19) TCTGCTGA 1 chr11:76487668-76487748 ( 39) TCTGCTGA 1 chr1:227530281-227530361 ( 39) TCTGCTGA 1 chr6:125432546-125432626 ( 22) TCTGCTGA 1 chr5:147978971-147979051 ( 32) TCAGCAGT 1 chr4:123964316-123964396 ( 59) TCAGCAGT 1 chr7:127835068-127835148 ( 29) TCAGCTGT 1 chr7:12741181-12741261 ( 31) TCAGCTGT 1 chr3:72274071-72274151 ( 31) TCAGCTGT 1 chr1:224531442-224531522 ( 41) TCAGCTGT 1 chr8:42344138-42344218 ( 43) TCAGCTGT 1 chr3:5490660-5490740 ( 30) TCAGCTGT 1 chr11:61766908-61766988 ( 26) TCTGCAGT 1 chr8:23457940-23458020 ( 48) TCTGCAGT 1 chr9:132275702-132275782 ( 40) TCTGCAGT 1 chr6:43424688-43424768 ( 52) TCAGCTGT 1 chr5:148990496-148990576 ( 48) TCTGCAGT 1 chr10:1024902-1024982 ( 35) TCAGCTGT 1 chr6:159390345-159390425 ( 57) TCAGCTGT 1 chr7:97726479-97726559 ( 54) TCAGCTGT 1 chr18:9975788-9975868 ( 50) TCAGCTGT 1 chr19:40531974-40532054 ( 19) TCAGCTGT 1 chr1:91344981-91345061 ( 35) TCAGCTGT 1 chr1:54399997-54400077 ( 46) TCAGCTGT 1 chr7:99536066-99536146 ( 50) TCAGCTGT 1 chr2:25117756-25117836 ( 66) TCTGCTGT 1 chr7:149408057-149408137 ( 32) ACAGCAGA 1 chr2:109486664-109486744 ( 33) ACAGCAGA 1 chr1:114389411-114389491 ( 26) TCTGCTGT 1 chr3:14946698-14946778 ( 44) TCTGCTGT 1 chr1:236545011-236545091 ( 27) TCTGCTGT 1 chr10:71309916-71309996 ( 44) ACAGCAGA 1 chr7:65730743-65730823 ( 36) ACAGCAGA 1 chr20:726503-726583 ( 24) ACAGCAGA 1 chr6:159326497-159326577 ( 34) ACAGCAGA 1 chr8:145838892-145838972 ( 61) TCTGCTGT 1 chr1:197694356-197694436 ( 34) ACAGCAGA 1 chr19:55439851-55439931 ( 19) ACAGCAGA 1 chr15:82285008-82285088 ( 38) ACAGCAGA 1 chr2:6971533-6971613 ( 37) ACAGCAGA 1 chr1:207051941-207052021 ( 40) TCTGCTGT 1 chr14:70107805-70107885 ( 27) TCTGCTGT 1 chr9:134418657-134418737 ( 48) TCTGCTGT 1 chr12:96738210-96738290 ( 61) ACAGCTGA 1 chr4:2134334-2134414 ( 35) ACTGCAGA 1 chr11:70597404-70597484 ( 28) ACTGCAGA 1 chr7:50286328-50286408 ( 29) ACAGCTGA 1 chr7:158500394-158500474 ( 55) ACAGCTGA 1 chr11:87049232-87049312 ( 38) ACAGCTGA 1 chr6:108563629-108563709 ( 37) ACAGCTGA 1 chr2:241471621-241471701 ( 10) ACAGCTGA 1 chr7:18301875-18301955 ( 32) ACAGCTGA 1 chr2:38966829-38966909 ( 40) ACAGCTGA 1 chr2:112962144-112962224 ( 44) TCATCAGA 1 chr12:51193893-51193973 ( 51) TCATCAGA 1 chr17:59697066-59697146 ( 70) TCAGAAGA 1 chr8:127288166-127288246 ( 38) TCAGAAGA 1 chr5:118593469-118593549 ( 18) TCAGAAGA 1 chr7:92418044-92418124 ( 46) TCATCAGA 1 chr3:169929636-169929716 ( 42) TCATCAGA 1 chr20:33784302-33784382 ( 33) TCATCAGA 1 chr1:200948903-200948983 ( 72) TCTGAAGA 1 chr7:138054719-138054799 ( 67) GCAGCAGA 1 chr2:158579286-158579366 ( 42) GCAGCAGA 1 chr10:75077154-75077234 ( 16) TCAGATGA 1 chr10:29134084-29134164 ( 50) GCAGCAGA 1 chr1:154268239-154268319 ( 55) TCTTCAGA 1 chr2:97043201-97043281 ( 27) TCTGAAGA 1 chr12:132678763-13267884 ( 62) GCAGCAGA 1 chr8:91151332-91151412 ( 37) GCAGCAGA 1 chr7:106664110-106664190 ( 69) TCAGATGA 1 chr9:138787219-138787299 ( 15) TCATCTGA 1 chr1:55109554-55109634 ( 27) TCAGATGA 1 chr8:8293290-8293370 ( 10) TCTTCTGA 1 chr7:106677142-106677222 ( 65) TCTGATGA 1 chr1:11566126-11566206 ( 16) TCTTCTGA 1 chr6:158379240-158379320 ( 36) TCTGATGA 1 chr7:155441546-155441626 ( 2) TCTGATGA 1 chr9:132064367-132064447 ( 40) TCTGATGA 1 chr1:26697614-26697694 ( 66) GCAGCTGA 1 chr3:157918933-157919013 ( 37) TCTTCTGA 1 chr1:11817281-11817361 ( 38) GCAGCTGA 1 chr7:149163617-149163697 ( 41) TCTTCTGA 1 chr7:86957778-86957858 ( 54) TCAGCAGG 1 chr7:101490622-101490702 ( 39) TCAGCAGC 1 chr12:1856935-1857015 ( 13) TCAGCTGC 1 chr7:75272371-75272451 ( 38) TCTGCAGC 1 chr21:31032850-31032930 ( 47) TCTGCTGC 1 chr7:77450482-77450562 ( 6) TCTGCTGG 1 chr22:21332920-21333000 ( 35) TCTGCTGC 1 chr6:157346782-157346862 ( 57) TCATCAGT 1 chr10:76576948-76577028 ( 7) TCATCAGT 1 chr2:24643414-24643494 ( 15) TCTTCAGT 1 chr19:8917505-8917585 ( 1) TCAGATGT 1 chr3:33740953-33741033 ( 37) ACAGAAGA 1 chr12:117001223-11700130 ( 21) TCTTCTGT 1 chr6:27282015-27282095 ( 5) ACAGAAGA 1 chr11:93708073-93708153 ( 52) TCTGATGT 1 chr19:5515887-5515967 ( 3) GCTGCTGT 1 chr7:156526559-156526639 ( 26) ACAGATGA 1 chr3:150393500-150393580 ( 12) ACTGAAGA 1 chr11:77526058-77526138 ( 37) ACTTCAGA 1 chr1:203064344-203064424 ( 8) ACTGATGA 1 chr9:126590945-126591025 ( 37) CCAGCAGA 1 chr14:100621486-10062156 ( 65) ACAGCAGG 1 chr1:196504985-196505065 ( 58) CCTGCTGA 1 chr9:130288231-130288311 ( 14) ACAGCAGG 1 chr3:136404904-136404984 ( 49) ACAGCAGG 1 chr1:167946639-167946719 ( 48) ACATCAGT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWGCWGA MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 7.86403 E= 9.9e-076 -33 -384 -189 132 -1371 222 -1371 -1371 91 -1371 -1371 74 -1371 -1371 198 -115 -99 200 -1371 -1371 93 -1371 -1371 72 -1371 -1371 217 -1371 120 -252 -257 -3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWGCWGA MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 134 E= 9.9e-076 0.223881 0.014925 0.059701 0.701493 0.000000 1.000000 0.000000 0.000000 0.529851 0.000000 0.000000 0.470149 0.000000 0.000000 0.873134 0.126866 0.141791 0.858209 0.000000 0.000000 0.537313 0.000000 0.000000 0.462687 0.000000 0.000000 1.000000 0.000000 0.649254 0.037313 0.037313 0.276119 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWGCWGA MEME-1 regular expression -------------------------------------------------------------------------------- [TA]C[AT]GC[AT]G[AT] -------------------------------------------------------------------------------- Time 4.78 secs. ******************************************************************************** ******************************************************************************** MOTIF RCAAKGGA MEME-2 width = 8 sites = 65 llr = 534 E-value = 8.7e-031 ******************************************************************************** -------------------------------------------------------------------------------- Motif RCAAKGGA MEME-2 Description -------------------------------------------------------------------------------- Simplified A 6:8a:::a pos.-specific C :a1:::3: probability G 4:::4a7: matrix T ::2:6::: bits 2.2 * 2.0 * * 1.8 * * * * 1.6 * * * * Relative 1.3 * * *** Entropy 1.1 * ***** (11.9 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel ACAATGGA consensus G G C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCAAKGGA MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr4:2134334-2134414 73 1.88e-05 agaccagaag acaatgga chr5:79016119-79016199 64 1.88e-05 atcaatacaa acaatgga agacagaag chr1:117437857-117437937 62 1.88e-05 aagccagaag acaatgga aatgacatct chr7:149408057-149408137 70 1.88e-05 aagtcaggag acaatgga ata chr1:154268239-154268319 64 1.88e-05 ctcttcagaa acaatgga gaccaggag chr7:50286328-50286408 67 1.88e-05 aaaccagaag acaatgga ataata chr5:147978971-147979051 57 1.88e-05 gaagtcaaac acaatgga atgaacaatt chr17:59697066-59697146 60 1.88e-05 ttcaatgtaa acaatgga agtcagaaga chr5:10740671-10740751 46 1.88e-05 ctcgctgtac acaatgga agccagaaaa chr6:27282015-27282095 49 1.88e-05 ctcatgtgaa acaatgga ggccagaggc chr6:108563629-108563709 58 1.88e-05 ctcaccagaa acaatgga gacaaggaag chr9:135572835-135572915 52 1.88e-05 atgtgagaag acaatgga aaggtgcctt chr2:241471621-241471701 48 1.88e-05 aagccaggaa acaatgga gtagaatctt chr6:159326497-159326577 55 1.88e-05 ctcaacatta acaatgga agcaagaagt chr19:55439851-55439931 50 1.88e-05 TCTATTGAAG ACAATGGA TGATGGTATT chr8:102768635-102768715 9 1.88e-05 TCCCTGCA ACAATGGA TAGGCAATGA chr20:33784302-33784382 59 1.88e-05 aagccagaag acaatgga ataacacctt chr1:203064344-203064424 46 1.88e-05 aggccagaag acaatgga gcaacatctt chr2:38966829-38966909 61 1.88e-05 ctcatctgga acaatgga gcccagaatg chr7:156526559-156526639 61 3.36e-05 aagtgagaag gcaatgga gcaacatctt chr7:5134452-5134532 42 3.36e-05 gagaccagaa gcaatgga atgaatatta chr1:197694356-197694436 55 3.36e-05 ctcaatagca gcaatgga agccagaaga chr4:56441845-56441925 15 4.84e-05 gtcatcacat acaaggga tcttcaataa chr7:92418044-92418124 12 4.84e-05 ctcatcacac acaaggga tctgcaataa chr3:169929636-169929716 7 4.84e-05 tcatgt acaaggga accctaataa chr3:158453234-158453314 31 6.01e-05 aagcctagct gcaaggga ggctggcaaa chr6:39139433-39139513 69 6.01e-05 acatgtagct gcaaggga gtct chr5:134318134-134318214 2 6.01e-05 a gcaaggga taagcaagtt chr2:169772283-169772363 50 6.01e-05 tcatctagct gcaaggga gtctaggaag chr7:29871482-29871562 28 6.01e-05 acacctagct gcaaggga ggctgggaga chr1:180557401-180557481 30 6.01e-05 tgtcccatct gcaaggga caccctttct chrX:39909950-39910030 11 6.01e-05 aaagctagct gcaaggga gtcaagtagt chr20:49038318-49038398 47 6.01e-05 gcacctagct gcaaggga agctaggaag chr1:234821938-234822018 45 7.82e-05 ctcataggaa acaatgca agtgaaaaga chr8:91151332-91151412 58 7.82e-05 ctaatcagaa acaatgca agtaagaaga chr1:68429111-68429191 23 1.18e-04 aattctttca gcaaggca atctttattt chr17:75170840-75170920 41 1.18e-04 ggatttctca gcaaggca atttactttt chr1:52682731-52682811 24 1.18e-04 aattttctca gcaaggca cttttacttc chr9:90282251-90282331 22 1.18e-04 gtggttctca gcaaggca attttgcctc chr17:75163948-75164028 22 1.18e-04 ttatttctca gcaaggca atttacttct chr7:66717092-66717172 14 1.18e-04 ttttttctca gcaaggca gtttacttct chr7:138114449-138114529 30 1.18e-04 ggatttctca gcaaggca aatttacttc chr7:158500394-158500474 43 1.18e-04 tggagggtga gcaaggca gagaacagct chr8:144751381-144751461 26 1.18e-04 TGCCttctca gcaaggca aatttacttc chr7:10798910-10798990 36 1.18e-04 ggatttctca gcaaggca aatttacttc chr15:93493004-93493084 22 1.18e-04 aattttctca gcaaggca attttacttt chr2:112962144-112962224 53 1.37e-04 ctcatcagaa actatgga agccagaaga chr11:70597404-70597484 48 1.37e-04 cctcatcaga actatgga ggtcagaagg chr12:51193893-51193973 60 1.37e-04 ctcatcagaa actatgga ggtgagaaga chr10:50474070-50474150 3 1.37e-04 aa actatgga gtctaggagg chr2:145476068-145476148 56 1.37e-04 tctgtcagaa actatgga aaccaaaagc chr21:46242948-46243028 57 1.66e-04 ttgtgacaaa accatgga agccaggtga chr4:88164743-88164823 9 1.66e-04 tcacctaa accatgga agccagaaag chr9:138787219-138787299 24 1.66e-04 ctcatctgaa gctatgga ggccagaggg chr7:18301875-18301955 53 1.66e-04 ctcttcagag accatgga ggttagaaga chr2:158579286-158579366 63 2.42e-04 ctcacaggaa actatgca aatgaaaaaa chr21:46248722-46248802 51 2.42e-04 gttagtagaa actatgca agccagaaga chr10:71309916-71309996 65 2.42e-04 ctcatcagaa actatgca agctggaa chr1:227530281-227530361 14 2.70e-04 AATTTTACTG ACCATGCA ATATGCTACA chr3:136404904-136404984 24 2.84e-04 tttagcagct actaggca aaactggcct chr12:132678763-13267884 17 2.95e-04 ccgagtgttg gccatgca gccgtgcagg chr7:86957778-86957858 3 2.95e-04 gt gccatgca tggatgcaag chr6:157927071-157927151 69 3.60e-04 CACTTAGTCT GGAATGGA ATCT chr9:130285826-130285906 3 3.76e-04 CC AGAAGGGA AATTAGAACA chr7:2064961-2065041 47 3.91e-04 gagtcaaaag acagtgga atgataggtt -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCAAKGGA MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:2134334-2134414 1.9e-05 72_[+2] chr5:79016119-79016199 1.9e-05 63_[+2]_9 chr1:117437857-117437937 1.9e-05 61_[+2]_11 chr7:149408057-149408137 1.9e-05 69_[+2]_3 chr1:154268239-154268319 1.9e-05 63_[+2]_9 chr7:50286328-50286408 1.9e-05 66_[+2]_6 chr5:147978971-147979051 1.9e-05 56_[+2]_16 chr17:59697066-59697146 1.9e-05 59_[+2]_13 chr5:10740671-10740751 1.9e-05 45_[+2]_27 chr6:27282015-27282095 1.9e-05 48_[+2]_24 chr6:108563629-108563709 1.9e-05 57_[+2]_15 chr9:135572835-135572915 1.9e-05 51_[+2]_21 chr2:241471621-241471701 1.9e-05 47_[+2]_25 chr6:159326497-159326577 1.9e-05 54_[+2]_18 chr19:55439851-55439931 1.9e-05 49_[+2]_23 chr8:102768635-102768715 1.9e-05 8_[+2]_64 chr20:33784302-33784382 1.9e-05 58_[+2]_14 chr1:203064344-203064424 1.9e-05 45_[+2]_27 chr2:38966829-38966909 1.9e-05 60_[+2]_12 chr7:156526559-156526639 3.4e-05 60_[+2]_12 chr7:5134452-5134532 3.4e-05 41_[+2]_31 chr1:197694356-197694436 3.4e-05 54_[+2]_18 chr4:56441845-56441925 4.8e-05 14_[+2]_58 chr7:92418044-92418124 4.8e-05 11_[+2]_61 chr3:169929636-169929716 4.8e-05 6_[+2]_66 chr3:158453234-158453314 6e-05 30_[+2]_42 chr6:39139433-39139513 6e-05 68_[+2]_4 chr5:134318134-134318214 6e-05 1_[+2]_71 chr2:169772283-169772363 6e-05 49_[+2]_23 chr7:29871482-29871562 6e-05 27_[+2]_45 chr1:180557401-180557481 6e-05 29_[+2]_43 chrX:39909950-39910030 6e-05 10_[+2]_62 chr20:49038318-49038398 6e-05 46_[+2]_26 chr1:234821938-234822018 7.8e-05 44_[+2]_28 chr8:91151332-91151412 7.8e-05 57_[+2]_15 chr1:68429111-68429191 0.00012 22_[+2]_50 chr17:75170840-75170920 0.00012 40_[+2]_32 chr1:52682731-52682811 0.00012 23_[+2]_49 chr9:90282251-90282331 0.00012 21_[+2]_51 chr17:75163948-75164028 0.00012 21_[+2]_51 chr7:66717092-66717172 0.00012 13_[+2]_59 chr7:138114449-138114529 0.00012 29_[+2]_43 chr7:158500394-158500474 0.00012 42_[+2]_30 chr8:144751381-144751461 0.00012 25_[+2]_47 chr7:10798910-10798990 0.00012 35_[+2]_37 chr15:93493004-93493084 0.00012 21_[+2]_51 chr2:112962144-112962224 0.00014 52_[+2]_20 chr11:70597404-70597484 0.00014 47_[+2]_25 chr12:51193893-51193973 0.00014 59_[+2]_13 chr10:50474070-50474150 0.00014 2_[+2]_70 chr2:145476068-145476148 0.00014 55_[+2]_17 chr21:46242948-46243028 0.00017 56_[+2]_16 chr4:88164743-88164823 0.00017 8_[+2]_64 chr9:138787219-138787299 0.00017 23_[+2]_49 chr7:18301875-18301955 0.00017 52_[+2]_20 chr2:158579286-158579366 0.00024 62_[+2]_10 chr21:46248722-46248802 0.00024 50_[+2]_22 chr10:71309916-71309996 0.00024 64_[+2]_8 chr1:227530281-227530361 0.00027 13_[+2]_59 chr3:136404904-136404984 0.00028 23_[+2]_49 chr12:132678763-13267884 0.00029 16_[+2]_56 chr7:86957778-86957858 0.00029 2_[+2]_70 chr6:157927071-157927151 0.00036 68_[+2]_4 chr9:130285826-130285906 0.00038 2_[+2]_70 chr7:2064961-2065041 0.00039 46_[+2]_26 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCAAKGGA MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF RCAAKGGA width=8 seqs=65 chr4:2134334-2134414 ( 73) ACAATGGA 1 chr5:79016119-79016199 ( 64) ACAATGGA 1 chr1:117437857-117437937 ( 62) ACAATGGA 1 chr7:149408057-149408137 ( 70) ACAATGGA 1 chr1:154268239-154268319 ( 64) ACAATGGA 1 chr7:50286328-50286408 ( 67) ACAATGGA 1 chr5:147978971-147979051 ( 57) ACAATGGA 1 chr17:59697066-59697146 ( 60) ACAATGGA 1 chr5:10740671-10740751 ( 46) ACAATGGA 1 chr6:27282015-27282095 ( 49) ACAATGGA 1 chr6:108563629-108563709 ( 58) ACAATGGA 1 chr9:135572835-135572915 ( 52) ACAATGGA 1 chr2:241471621-241471701 ( 48) ACAATGGA 1 chr6:159326497-159326577 ( 55) ACAATGGA 1 chr19:55439851-55439931 ( 50) ACAATGGA 1 chr8:102768635-102768715 ( 9) ACAATGGA 1 chr20:33784302-33784382 ( 59) ACAATGGA 1 chr1:203064344-203064424 ( 46) ACAATGGA 1 chr2:38966829-38966909 ( 61) ACAATGGA 1 chr7:156526559-156526639 ( 61) GCAATGGA 1 chr7:5134452-5134532 ( 42) GCAATGGA 1 chr1:197694356-197694436 ( 55) GCAATGGA 1 chr4:56441845-56441925 ( 15) ACAAGGGA 1 chr7:92418044-92418124 ( 12) ACAAGGGA 1 chr3:169929636-169929716 ( 7) ACAAGGGA 1 chr3:158453234-158453314 ( 31) GCAAGGGA 1 chr6:39139433-39139513 ( 69) GCAAGGGA 1 chr5:134318134-134318214 ( 2) GCAAGGGA 1 chr2:169772283-169772363 ( 50) GCAAGGGA 1 chr7:29871482-29871562 ( 28) GCAAGGGA 1 chr1:180557401-180557481 ( 30) GCAAGGGA 1 chrX:39909950-39910030 ( 11) GCAAGGGA 1 chr20:49038318-49038398 ( 47) GCAAGGGA 1 chr1:234821938-234822018 ( 45) ACAATGCA 1 chr8:91151332-91151412 ( 58) ACAATGCA 1 chr1:68429111-68429191 ( 23) GCAAGGCA 1 chr17:75170840-75170920 ( 41) GCAAGGCA 1 chr1:52682731-52682811 ( 24) GCAAGGCA 1 chr9:90282251-90282331 ( 22) GCAAGGCA 1 chr17:75163948-75164028 ( 22) GCAAGGCA 1 chr7:66717092-66717172 ( 14) GCAAGGCA 1 chr7:138114449-138114529 ( 30) GCAAGGCA 1 chr7:158500394-158500474 ( 43) GCAAGGCA 1 chr8:144751381-144751461 ( 26) GCAAGGCA 1 chr7:10798910-10798990 ( 36) GCAAGGCA 1 chr15:93493004-93493084 ( 22) GCAAGGCA 1 chr2:112962144-112962224 ( 53) ACTATGGA 1 chr11:70597404-70597484 ( 48) ACTATGGA 1 chr12:51193893-51193973 ( 60) ACTATGGA 1 chr10:50474070-50474150 ( 3) ACTATGGA 1 chr2:145476068-145476148 ( 56) ACTATGGA 1 chr21:46242948-46243028 ( 57) ACCATGGA 1 chr4:88164743-88164823 ( 9) ACCATGGA 1 chr9:138787219-138787299 ( 24) GCTATGGA 1 chr7:18301875-18301955 ( 53) ACCATGGA 1 chr2:158579286-158579366 ( 63) ACTATGCA 1 chr21:46248722-46248802 ( 51) ACTATGCA 1 chr10:71309916-71309996 ( 65) ACTATGCA 1 chr1:227530281-227530361 ( 14) ACCATGCA 1 chr3:136404904-136404984 ( 24) ACTAGGCA 1 chr12:132678763-13267884 ( 17) GCCATGCA 1 chr7:86957778-86957858 ( 3) GCCATGCA 1 chr6:157927071-157927151 ( 69) GGAATGGA 1 chr9:130285826-130285906 ( 3) AGAAGGGA 1 chr7:2064961-2065041 ( 47) ACAGTGGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCAAKGGA MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.88203 E= 8.7e-031 109 -1267 85 -1267 -1267 218 -285 -1267 142 -121 -1267 -87 180 -1267 -385 -1267 -1267 -1267 73 116 -1267 -1267 217 -1267 -1267 52 164 -1267 183 -1267 -1267 -1267 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCAAKGGA MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 65 E= 8.7e-031 0.600000 0.000000 0.400000 0.000000 0.000000 0.969231 0.030769 0.000000 0.753846 0.092308 0.000000 0.153846 0.984615 0.000000 0.015385 0.000000 0.000000 0.000000 0.369231 0.630769 0.000000 0.000000 1.000000 0.000000 0.000000 0.307692 0.692308 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCAAKGGA MEME-2 regular expression -------------------------------------------------------------------------------- [AG]CAA[TG]G[GC]A -------------------------------------------------------------------------------- Time 8.21 secs. ******************************************************************************** ******************************************************************************** MOTIF TTCCAYTG MEME-3 width = 8 sites = 81 llr = 593 E-value = 1.7e-019 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTCCAYTG MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::::8::: pos.-specific C 219a13:: probability G :11:::1a matrix T 79::179: bits 2.2 2.0 * * 1.8 * * 1.6 * * Relative 1.3 ** * Entropy 1.1 *** *** (10.6 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TTCCATTG consensus C C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCCAYTG MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:131021797-131021877 17 1.81e-05 gtcttctagc ttccattg tttctgttgc chr8:8293290-8293370 19 1.81e-05 gtcttctgac ttccattg ttgctgtaaa chr7:12741181-12741261 9 1.81e-05 cttcttgt ttccattg tttttgttgg chr10:75077154-75077234 6 1.81e-05 ctggc ttccattg tttcagatga chr6:157346782-157346862 18 1.81e-05 gtgagtcgtt ttccattg tttggctatg chr21:38774710-38774790 36 1.81e-05 gtcttctggc ttccattg tttgtgatga chr6:13942342-13942422 24 1.81e-05 gtcctctgtt ttccattg tttttgttga chr1:167946639-167946719 22 1.81e-05 atattctgac ttccattg ttgaagttgc chr3:150393500-150393580 22 1.81e-05 actgaagaca ttccattg cctttgagcc chr12:117001223-11700130 13 1.81e-05 aagggtgtta ttccattg tcttctgtgt chr8:23457940-23458020 9 1.81e-05 agatcctg ttccattg tcttctagcc chr9:132275702-132275782 2 1.81e-05 g ttccattg tttgctgact chr18:9975788-9975868 13 1.81e-05 aaagatatca ttccattg tctttgggct chr19:40531974-40532054 40 1.81e-05 tcgattggtg ttccattg taagcgacac chr7:77450482-77450562 59 1.81e-05 ctaatgggaa ttccattg tatgtgactt chr2:146172894-146172974 4 1.81e-05 tca ttccattg tcttctggct chr11:57386950-57387030 5 1.81e-05 aggg ttccattg caatgagtct chr7:50286328-50286408 21 3.19e-05 taaatggcaa ttccactg acagctgact chr8:42344138-42344218 65 3.19e-05 cttacttgag ttccactg gacttgac chr3:157918933-157919013 29 3.19e-05 aagaatttca ttccactg tcttctgatt chr11:93708073-93708153 13 3.19e-05 gaaggcatta ttccactg tcttctagct chr1:54399997-54400077 24 3.19e-05 gttgtctggc ttccactg tttgtgatgt chr5:125980997-125981077 2 3.19e-05 a ttccactg ccttctggct chr1:11566126-11566206 8 4.56e-05 gatgtca ctccattg tcttctgact chr4:123964316-123964396 20 4.56e-05 agcacttgtc ctccattg tcacttggct chr6:43424688-43424768 1 4.56e-05 . CTCCATTG GATATAACAC chr1:224359011-224359091 19 5.61e-05 gccttctggc ctccactg tttctcatga chr3:14946698-14946778 5 5.61e-05 gcca ctccactg tcttctggtg chr6:44027508-44027588 56 6.98e-05 actacctagc ttcccttg cagctaggta chr22:25112731-25112811 69 8.80e-05 ttgagtgcta ttcctttg cagc chr2:97043201-97043281 59 8.80e-05 ctcgtcacta ttcctttg tatgtaattg chr7:75436042-75436122 38 1.13e-04 tctgttgcaa ttcccctg tcttgataaa chr16:11301656-11301736 2 1.13e-04 c ttccatgg gaggagccca chr5:452335-452415 35 1.40e-04 acttgatatt tcccattg tcctgtcttc chr2:44537575-44537655 22 1.40e-04 gaatatgtca tcccattg ccctctggcc chr4:83945533-83945613 56 1.40e-04 tctgttgtaa ttcctctg taagtaatgt chr7:64869085-64869165 29 1.40e-04 cattgcttag ttcctctg gatccatggc chr2:112734953-112735033 70 1.40e-04 cctaactttg ttcctctg tat chr6:159390345-159390425 18 1.40e-04 gaatatatga tcccattg ccttttggcc chr6:107106485-107106565 54 1.40e-04 cttatggtca ttcctctg tatatgatgt chr22:21332920-21333000 11 1.40e-04 CATCTCCCCT TTCCTCTG CCTTTACACC chr8:145838892-145838972 39 1.73e-04 gtcttcgcac ttgcattg tttctcatga chr1:180557401-180557481 14 1.73e-04 tgtgtgccct tgccattg tcccatctgc chr20:62776966-62777046 46 1.98e-04 aagaccggtg ttccacgg cgacaccttg chr20:32535674-32535754 45 1.98e-04 atggctgctt gtccattg ctgccagatg chr7:149163617-149163697 33 1.98e-04 gtagatgtta gtccattg tcttctgact chr7:101490622-101490702 53 2.09e-04 CAGCCATGCG TCCCACTG TCTAGgcagt chr3:5490660-5490740 73 2.63e-04 gttaaacact tgccactg chr19:8917505-8917585 27 2.63e-04 gtcttcttgc ttccatag tttcttttga chr6:34526126-34526206 20 2.63e-04 ctatcccagc ctcccttg cagctagatg chr5:37775136-37775216 48 2.63e-04 CACCATTAGG TGCCACTG TTTGACAGGA chr1:53603581-53603661 59 2.76e-04 gctgaaacat ctcctttg gtagctttct chr20:36871392-36871472 25 2.87e-04 AGTTGAGCCT GTCCActg ggctgtgcgg chr1:224531442-224531522 19 3.20e-04 gccacctagc ctccatgg tttctgatga chr6:90996755-90996835 30 3.20e-04 TGCAagacag ttccacag actggcacta chr5:173019233-173019313 53 3.20e-04 tcctgcacag ctccatgg acattcacac chr7:97726479-97726559 32 3.20e-04 accttctggc ctccatgg tttctgatga chr7:99536066-99536146 29 3.20e-04 gtcttctggc ctccatgg ttttgaggag chr3:72274071-72274151 9 3.88e-04 ctctgatc ccccattg cttctggtgg chr2:113758157-113758237 14 3.88e-04 gtcttttggc tttcattg ttgtaattga chr2:169772283-169772363 10 3.88e-04 gtgcctata tttcattg acaagacaat chr14:70107805-70107885 44 3.88e-04 taattctttg ctcctctg tctgccatgt chr2:145476068-145476148 6 3.88e-04 aaata ttacattg agaggaacaa chr7:106677142-106677222 27 4.37e-04 aggatattag ttctattg tcttccagct chr1:244739732-244739812 33 4.37e-04 agggtgctct cgccattg ctccatctgc chr19:55439851-55439931 39 4.37e-04 TCTCGATATG TTCTATTG AAGACAATGG chr3:158453234-158453314 10 5.13e-04 agatctggg ttacactg gcaaagccta chr5:79016119-79016199 35 5.13e-04 aaagtgacag ttacactg acagccaact chr12:1856935-1857015 34 5.13e-04 tcttactggg ttccattt taaaataatg chr7:75272371-75272451 71 5.13e-04 ACACTGAGGT TTTCACTG CC chr2:25117756-25117836 27 5.64e-04 tctttttcag ttctactg tcttctgcct chr1:91344981-91345061 13 5.64e-04 gccttctgac ctccatag tttctgagga chr8:102768635-102768715 59 5.64e-04 tgttcaacag cgccactg tgtggcagtg chr1:55109554-55109634 17 5.64e-04 tccttttggc ctccatag tttcagatga chr9:132064367-132064447 13 6.35e-04 cgctttgatg ttccactt tctggtcacc chr1:26595781-26595861 48 6.84e-04 aaagtaaaaa ttgccttg ctgaggaaat chr11:61766908-61766988 42 6.84e-04 gtaagtaaaa ttgccttg ctgtgaaaac chr17:37203401-37203481 43 6.84e-04 gaaagtaaat ttgccttg ctgagaaaat chr6:118895571-118895651 38 6.84e-04 cagaagtaaa ttgccttg ctgagaaaac chr3:12906933-12907013 38 6.84e-04 cagaagtaaa ttgccttg ctgagagaat chr13:41722987-41723067 13 7.67e-04 ttggatgtaa atccactg ggtctgagtg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCCAYTG MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:131021797-131021877 1.8e-05 16_[+3]_56 chr8:8293290-8293370 1.8e-05 18_[+3]_54 chr7:12741181-12741261 1.8e-05 8_[+3]_64 chr10:75077154-75077234 1.8e-05 5_[+3]_67 chr6:157346782-157346862 1.8e-05 17_[+3]_55 chr21:38774710-38774790 1.8e-05 35_[+3]_37 chr6:13942342-13942422 1.8e-05 23_[+3]_49 chr1:167946639-167946719 1.8e-05 21_[+3]_51 chr3:150393500-150393580 1.8e-05 21_[+3]_51 chr12:117001223-11700130 1.8e-05 12_[+3]_60 chr8:23457940-23458020 1.8e-05 8_[+3]_64 chr9:132275702-132275782 1.8e-05 1_[+3]_71 chr18:9975788-9975868 1.8e-05 12_[+3]_60 chr19:40531974-40532054 1.8e-05 39_[+3]_33 chr7:77450482-77450562 1.8e-05 58_[+3]_14 chr2:146172894-146172974 1.8e-05 3_[+3]_69 chr11:57386950-57387030 1.8e-05 4_[+3]_68 chr7:50286328-50286408 3.2e-05 20_[+3]_52 chr8:42344138-42344218 3.2e-05 64_[+3]_8 chr3:157918933-157919013 3.2e-05 28_[+3]_44 chr11:93708073-93708153 3.2e-05 12_[+3]_60 chr1:54399997-54400077 3.2e-05 23_[+3]_49 chr5:125980997-125981077 3.2e-05 1_[+3]_71 chr1:11566126-11566206 4.6e-05 7_[+3]_65 chr4:123964316-123964396 4.6e-05 19_[+3]_53 chr6:43424688-43424768 4.6e-05 [+3]_72 chr1:224359011-224359091 5.6e-05 18_[+3]_54 chr3:14946698-14946778 5.6e-05 4_[+3]_68 chr6:44027508-44027588 7e-05 55_[+3]_17 chr22:25112731-25112811 8.8e-05 68_[+3]_4 chr2:97043201-97043281 8.8e-05 58_[+3]_14 chr7:75436042-75436122 0.00011 37_[+3]_35 chr16:11301656-11301736 0.00011 1_[+3]_71 chr5:452335-452415 0.00014 34_[+3]_38 chr2:44537575-44537655 0.00014 21_[+3]_51 chr4:83945533-83945613 0.00014 55_[+3]_17 chr7:64869085-64869165 0.00014 28_[+3]_44 chr2:112734953-112735033 0.00014 69_[+3]_3 chr6:159390345-159390425 0.00014 17_[+3]_55 chr6:107106485-107106565 0.00014 53_[+3]_19 chr22:21332920-21333000 0.00014 10_[+3]_62 chr8:145838892-145838972 0.00017 38_[+3]_34 chr1:180557401-180557481 0.00017 13_[+3]_59 chr20:62776966-62777046 0.0002 45_[+3]_27 chr20:32535674-32535754 0.0002 44_[+3]_28 chr7:149163617-149163697 0.0002 32_[+3]_40 chr7:101490622-101490702 0.00021 52_[+3]_20 chr3:5490660-5490740 0.00026 72_[+3] chr19:8917505-8917585 0.00026 26_[+3]_46 chr6:34526126-34526206 0.00026 19_[+3]_53 chr5:37775136-37775216 0.00026 47_[+3]_25 chr1:53603581-53603661 0.00028 58_[+3]_14 chr20:36871392-36871472 0.00029 24_[+3]_48 chr1:224531442-224531522 0.00032 18_[+3]_54 chr6:90996755-90996835 0.00032 29_[+3]_43 chr5:173019233-173019313 0.00032 52_[+3]_20 chr7:97726479-97726559 0.00032 31_[+3]_41 chr7:99536066-99536146 0.00032 28_[+3]_44 chr3:72274071-72274151 0.00039 8_[+3]_64 chr2:113758157-113758237 0.00039 13_[+3]_59 chr2:169772283-169772363 0.00039 9_[+3]_63 chr14:70107805-70107885 0.00039 43_[+3]_29 chr2:145476068-145476148 0.00039 5_[+3]_67 chr7:106677142-106677222 0.00044 26_[+3]_46 chr1:244739732-244739812 0.00044 32_[+3]_40 chr19:55439851-55439931 0.00044 38_[+3]_34 chr3:158453234-158453314 0.00051 9_[+3]_63 chr5:79016119-79016199 0.00051 34_[+3]_38 chr12:1856935-1857015 0.00051 33_[+3]_39 chr7:75272371-75272451 0.00051 70_[+3]_2 chr2:25117756-25117836 0.00056 26_[+3]_46 chr1:91344981-91345061 0.00056 12_[+3]_60 chr8:102768635-102768715 0.00056 58_[+3]_14 chr1:55109554-55109634 0.00056 16_[+3]_56 chr9:132064367-132064447 0.00063 12_[+3]_60 chr1:26595781-26595861 0.00068 47_[+3]_25 chr11:61766908-61766988 0.00068 41_[+3]_31 chr17:37203401-37203481 0.00068 42_[+3]_30 chr6:118895571-118895651 0.00068 37_[+3]_35 chr3:12906933-12907013 0.00068 37_[+3]_35 chr13:41722987-41723067 0.00077 12_[+3]_60 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCCAYTG MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTCCAYTG width=8 seqs=81 chr7:131021797-131021877 ( 17) TTCCATTG 1 chr8:8293290-8293370 ( 19) TTCCATTG 1 chr7:12741181-12741261 ( 9) TTCCATTG 1 chr10:75077154-75077234 ( 6) TTCCATTG 1 chr6:157346782-157346862 ( 18) TTCCATTG 1 chr21:38774710-38774790 ( 36) TTCCATTG 1 chr6:13942342-13942422 ( 24) TTCCATTG 1 chr1:167946639-167946719 ( 22) TTCCATTG 1 chr3:150393500-150393580 ( 22) TTCCATTG 1 chr12:117001223-11700130 ( 13) TTCCATTG 1 chr8:23457940-23458020 ( 9) TTCCATTG 1 chr9:132275702-132275782 ( 2) TTCCATTG 1 chr18:9975788-9975868 ( 13) TTCCATTG 1 chr19:40531974-40532054 ( 40) TTCCATTG 1 chr7:77450482-77450562 ( 59) TTCCATTG 1 chr2:146172894-146172974 ( 4) TTCCATTG 1 chr11:57386950-57387030 ( 5) TTCCATTG 1 chr7:50286328-50286408 ( 21) TTCCACTG 1 chr8:42344138-42344218 ( 65) TTCCACTG 1 chr3:157918933-157919013 ( 29) TTCCACTG 1 chr11:93708073-93708153 ( 13) TTCCACTG 1 chr1:54399997-54400077 ( 24) TTCCACTG 1 chr5:125980997-125981077 ( 2) TTCCACTG 1 chr1:11566126-11566206 ( 8) CTCCATTG 1 chr4:123964316-123964396 ( 20) CTCCATTG 1 chr6:43424688-43424768 ( 1) CTCCATTG 1 chr1:224359011-224359091 ( 19) CTCCACTG 1 chr3:14946698-14946778 ( 5) CTCCACTG 1 chr6:44027508-44027588 ( 56) TTCCCTTG 1 chr22:25112731-25112811 ( 69) TTCCTTTG 1 chr2:97043201-97043281 ( 59) TTCCTTTG 1 chr7:75436042-75436122 ( 38) TTCCCCTG 1 chr16:11301656-11301736 ( 2) TTCCATGG 1 chr5:452335-452415 ( 35) TCCCATTG 1 chr2:44537575-44537655 ( 22) TCCCATTG 1 chr4:83945533-83945613 ( 56) TTCCTCTG 1 chr7:64869085-64869165 ( 29) TTCCTCTG 1 chr2:112734953-112735033 ( 70) TTCCTCTG 1 chr6:159390345-159390425 ( 18) TCCCATTG 1 chr6:107106485-107106565 ( 54) TTCCTCTG 1 chr22:21332920-21333000 ( 11) TTCCTCTG 1 chr8:145838892-145838972 ( 39) TTGCATTG 1 chr1:180557401-180557481 ( 14) TGCCATTG 1 chr20:62776966-62777046 ( 46) TTCCACGG 1 chr20:32535674-32535754 ( 45) GTCCATTG 1 chr7:149163617-149163697 ( 33) GTCCATTG 1 chr7:101490622-101490702 ( 53) TCCCACTG 1 chr3:5490660-5490740 ( 73) TGCCACTG 1 chr19:8917505-8917585 ( 27) TTCCATAG 1 chr6:34526126-34526206 ( 20) CTCCCTTG 1 chr5:37775136-37775216 ( 48) TGCCACTG 1 chr1:53603581-53603661 ( 59) CTCCTTTG 1 chr20:36871392-36871472 ( 25) GTCCACTG 1 chr1:224531442-224531522 ( 19) CTCCATGG 1 chr6:90996755-90996835 ( 30) TTCCACAG 1 chr5:173019233-173019313 ( 53) CTCCATGG 1 chr7:97726479-97726559 ( 32) CTCCATGG 1 chr7:99536066-99536146 ( 29) CTCCATGG 1 chr3:72274071-72274151 ( 9) CCCCATTG 1 chr2:113758157-113758237 ( 14) TTTCATTG 1 chr2:169772283-169772363 ( 10) TTTCATTG 1 chr14:70107805-70107885 ( 44) CTCCTCTG 1 chr2:145476068-145476148 ( 6) TTACATTG 1 chr7:106677142-106677222 ( 27) TTCTATTG 1 chr1:244739732-244739812 ( 33) CGCCATTG 1 chr19:55439851-55439931 ( 39) TTCTATTG 1 chr3:158453234-158453314 ( 10) TTACACTG 1 chr5:79016119-79016199 ( 35) TTACACTG 1 chr12:1856935-1857015 ( 34) TTCCATTT 1 chr7:75272371-75272451 ( 71) TTTCACTG 1 chr2:25117756-25117836 ( 27) TTCTACTG 1 chr1:91344981-91345061 ( 13) CTCCATAG 1 chr8:102768635-102768715 ( 59) CGCCACTG 1 chr1:55109554-55109634 ( 17) CTCCATAG 1 chr9:132064367-132064447 ( 13) TTCCACTT 1 chr1:26595781-26595861 ( 48) TTGCCTTG 1 chr11:61766908-61766988 ( 42) TTGCCTTG 1 chr17:37203401-37203481 ( 43) TTGCCTTG 1 chr6:118895571-118895651 ( 38) TTGCCTTG 1 chr3:12906933-12907013 ( 38) TTGCCTTG 1 chr13:41722987-41723067 ( 13) ATCCACTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCCAYTG MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 8.07559 E= 1.7e-019 -451 -3 -258 139 -1298 -180 -185 164 -293 199 -158 -293 -1298 217 -1298 -293 149 -112 -1298 -134 -1298 69 -1298 122 -251 -1298 -158 164 -1298 -1298 214 -351 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCCAYTG MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 81 E= 1.7e-019 0.012346 0.209877 0.037037 0.740741 0.000000 0.061728 0.061728 0.876543 0.037037 0.851852 0.074074 0.037037 0.000000 0.962963 0.000000 0.037037 0.790123 0.098765 0.000000 0.111111 0.000000 0.345679 0.000000 0.654321 0.049383 0.000000 0.074074 0.876543 0.000000 0.000000 0.975309 0.024691 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTCCAYTG MEME-3 regular expression -------------------------------------------------------------------------------- [TC]TCCA[TC]TG -------------------------------------------------------------------------------- Time 11.55 secs. ******************************************************************************** ******************************************************************************** MOTIF CTTCTGGC MEME-4 width = 8 sites = 28 llr = 257 E-value = 2.3e-007 ******************************************************************************** -------------------------------------------------------------------------------- Motif CTTCTGGC MEME-4 Description -------------------------------------------------------------------------------- Simplified A :::::11: pos.-specific C a::9:1:9 probability G ::1::89: matrix T :a91a1:1 bits 2.2 * 2.0 * 1.8 ** ** ** 1.6 ** ** ** Relative 1.3 ***** ** Entropy 1.1 ***** ** (13.2 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CTTCTGGC consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTTCTGGC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr21:38774710-38774790 28 1.08e-05 gttccattgt cttctggc ttccattgtt chr11:76487668-76487748 9 1.08e-05 cccactgc cttctggc ctccaaagtt chr2:97043201-97043281 9 1.08e-05 tccaatgt cttctggc ttccatagtt chr1:224359011-224359091 11 1.08e-05 atcccactgc cttctggc ctccactgtt chr8:144751381-144751461 65 1.08e-05 gccgctctct cttctggc cactggga chr7:97726479-97726559 24 1.08e-05 gtcccacaac cttctggc ctccatggtt chr6:107106485-107106565 5 1.08e-05 ttgt cttctggc ttacatagtt chr2:146172894-146172974 13 1.08e-05 attccattgt cttctggc tttcatgact chr7:99536066-99536146 21 1.08e-05 gttccagtgt cttctggc ctccatggtt chr5:125980997-125981077 11 1.08e-05 attccactgc cttctggc tgccactgtt chr7:131021797-131021877 9 2.46e-05 ttcattgt cttctagc ttccattgtt chr8:23457940-23458020 18 2.46e-05 gttccattgt cttctagc ctccatggtt chr11:93708073-93708153 22 2.46e-05 attccactgt cttctagc ttccagtgtt chr19:8134385-8134465 52 3.31e-05 TTACTGACCC CTGCTGGC AGTCAGTGGG chr3:10287144-10287224 19 3.31e-05 cgtggcaaaa ctgctggc gagtgtaccc chr3:72274071-72274151 17 7.21e-05 tcccccattg cttctggt ggaaagtcag chr5:10740671-10740751 33 7.21e-05 ttatggctga cttctcgc tgtacacaat chr3:14946698-14946778 14 7.21e-05 actccactgt cttctggt gtacatcgtt chr2:113758157-113758237 6 7.21e-05 attgt cttttggc tttcattgtt chr2:112734953-112735033 19 7.21e-05 gctcccctat cttctcgc ttgcattgtt chr6:159390345-159390425 27 7.21e-05 atcccattgc cttttggc cttcatgatg chr1:55109554-55109634 9 7.21e-05 gccacttc cttttggc ctccatagtt chr22:21332920-21333000 54 7.21e-05 TGAAACCCCA CTTCTGGT ACCAATTTCT chr7:127835068-127835148 59 8.59e-05 ttaatgtgtc cttcttgc cctcccccca chr19:8917505-8917585 19 8.59e-05 cattcattgt cttcttgc ttccatagtt chr3:196710224-196710304 1 9.96e-05 . cttctgac ttctgttgtg chr1:91344981-91345061 5 9.96e-05 ctgc cttctgac ctccatagtt chr6:158379240-158379320 18 1.08e-04 actctattgt ctcctggc ttgcatagtt -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTTCTGGC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr21:38774710-38774790 1.1e-05 27_[+4]_45 chr11:76487668-76487748 1.1e-05 8_[+4]_64 chr2:97043201-97043281 1.1e-05 8_[+4]_64 chr1:224359011-224359091 1.1e-05 10_[+4]_62 chr8:144751381-144751461 1.1e-05 64_[+4]_8 chr7:97726479-97726559 1.1e-05 23_[+4]_49 chr6:107106485-107106565 1.1e-05 4_[+4]_68 chr2:146172894-146172974 1.1e-05 12_[+4]_60 chr7:99536066-99536146 1.1e-05 20_[+4]_52 chr5:125980997-125981077 1.1e-05 10_[+4]_62 chr7:131021797-131021877 2.5e-05 8_[+4]_64 chr8:23457940-23458020 2.5e-05 17_[+4]_55 chr11:93708073-93708153 2.5e-05 21_[+4]_51 chr19:8134385-8134465 3.3e-05 51_[+4]_21 chr3:10287144-10287224 3.3e-05 18_[+4]_54 chr3:72274071-72274151 7.2e-05 16_[+4]_56 chr5:10740671-10740751 7.2e-05 32_[+4]_40 chr3:14946698-14946778 7.2e-05 13_[+4]_59 chr2:113758157-113758237 7.2e-05 5_[+4]_67 chr2:112734953-112735033 7.2e-05 18_[+4]_54 chr6:159390345-159390425 7.2e-05 26_[+4]_46 chr1:55109554-55109634 7.2e-05 8_[+4]_64 chr22:21332920-21333000 7.2e-05 53_[+4]_19 chr7:127835068-127835148 8.6e-05 58_[+4]_14 chr19:8917505-8917585 8.6e-05 18_[+4]_54 chr3:196710224-196710304 0.0001 [+4]_72 chr1:91344981-91345061 0.0001 4_[+4]_68 chr6:158379240-158379320 0.00011 17_[+4]_55 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTTCTGGC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CTTCTGGC width=8 seqs=28 chr21:38774710-38774790 ( 28) CTTCTGGC 1 chr11:76487668-76487748 ( 9) CTTCTGGC 1 chr2:97043201-97043281 ( 9) CTTCTGGC 1 chr1:224359011-224359091 ( 11) CTTCTGGC 1 chr8:144751381-144751461 ( 65) CTTCTGGC 1 chr7:97726479-97726559 ( 24) CTTCTGGC 1 chr6:107106485-107106565 ( 5) CTTCTGGC 1 chr2:146172894-146172974 ( 13) CTTCTGGC 1 chr7:99536066-99536146 ( 21) CTTCTGGC 1 chr5:125980997-125981077 ( 11) CTTCTGGC 1 chr7:131021797-131021877 ( 9) CTTCTAGC 1 chr8:23457940-23458020 ( 18) CTTCTAGC 1 chr11:93708073-93708153 ( 22) CTTCTAGC 1 chr19:8134385-8134465 ( 52) CTGCTGGC 1 chr3:10287144-10287224 ( 19) CTGCTGGC 1 chr3:72274071-72274151 ( 17) CTTCTGGT 1 chr5:10740671-10740751 ( 33) CTTCTCGC 1 chr3:14946698-14946778 ( 14) CTTCTGGT 1 chr2:113758157-113758237 ( 6) CTTTTGGC 1 chr2:112734953-112735033 ( 19) CTTCTCGC 1 chr6:159390345-159390425 ( 27) CTTTTGGC 1 chr1:55109554-55109634 ( 9) CTTTTGGC 1 chr22:21332920-21333000 ( 54) CTTCTGGT 1 chr7:127835068-127835148 ( 59) CTTCTTGC 1 chr19:8917505-8917585 ( 19) CTTCTTGC 1 chr3:196710224-196710304 ( 1) CTTCTGAC 1 chr1:91344981-91345061 ( 5) CTTCTGAC 1 chr6:158379240-158379320 ( 18) CTCCTGGC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTTCTGGC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.95252 E= 2.3e-007 -1145 222 -1145 -1145 -1145 -1145 -1145 183 -1145 -258 -163 166 -1145 206 -1145 -139 -1145 -1145 -1145 183 -140 -158 176 -198 -198 -1145 206 -1145 -1145 206 -1145 -139 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTTCTGGC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 28 E= 2.3e-007 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.035714 0.071429 0.892857 0.000000 0.892857 0.000000 0.107143 0.000000 0.000000 0.000000 1.000000 0.107143 0.071429 0.750000 0.071429 0.071429 0.000000 0.928571 0.000000 0.000000 0.892857 0.000000 0.107143 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CTTCTGGC MEME-4 regular expression -------------------------------------------------------------------------------- CTTCTGGC -------------------------------------------------------------------------------- Time 14.79 secs. ******************************************************************************** ******************************************************************************** MOTIF GCCAGAAG MEME-5 width = 8 sites = 26 llr = 242 E-value = 1.6e-006 ******************************************************************************** -------------------------------------------------------------------------------- Motif GCCAGAAG MEME-5 Description -------------------------------------------------------------------------------- Simplified A 31:a:a9: pos.-specific C :8a:2::: probability G 7:::8:1a matrix T :::::::: bits 2.2 * * 2.0 * * 1.8 ** * * 1.6 ** *** Relative 1.3 ******** Entropy 1.1 ******** (13.4 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GCCAGAAG consensus A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCAGAAG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:112962144-112962224 62 1.12e-05 aactatggaa gccagaag acagtgggag chr1:117437857-117437937 54 1.12e-05 aacactgtaa gccagaag acaatggaaa chr9:126590945-126591025 55 1.12e-05 aacaatgtaa gccagaag acaatgagat chr21:46248722-46248802 60 1.12e-05 aactatgcaa gccagaag acaatgaagt chr11:87049232-87049312 68 1.12e-05 aacaataaag gccagaag gcaat chr1:197694356-197694436 64 1.12e-05 agcaatggaa gccagaag acagtggaa chr20:33784302-33784382 51 1.12e-05 gaccatggaa gccagaag acaatggaat chr4:95348099-95348179 63 1.12e-05 aactatgtaa gccagaag acatggaaca chr1:203064344-203064424 38 1.12e-05 tacaatgaag gccagaag acaatggagc chr4:2134334-2134414 65 2.55e-05 gaccatgcag accagaag acaatgga chr4:83945533-83945613 38 2.55e-05 ataatttgtg accagaag tctgttgtaa chr7:50286328-50286408 59 2.55e-05 agtaatggaa accagaag acaatggaat chr8:103689464-103689544 48 2.55e-05 atggggatat accagaag aggcagggct chr2:6971533-6971613 26 2.55e-05 gagagtaaca accagaag gggacagcag chr2:172386597-172386677 12 3.63e-05 gagtgatgtg gccacaag ccaaggaaaa chr19:5515887-5515967 24 3.63e-05 ttctgtggct gccacaag gtgttgctgt chr6:132244668-132244748 25 3.63e-05 ctaagtcatt gccacaag gtgtcgctgt chr5:79016119-79016199 73 6.00e-05 aacaatggaa gacagaag chr6:170792674-170792754 60 6.00e-05 aataatgcaa gacagaag gcagtggatc chr6:27282015-27282095 58 6.00e-05 aacaatggag gccagagg cagtgggata chr5:131641274-131641354 39 6.00e-05 aaccataaag gacagaag gcagtggagt chr9:138787219-138787299 33 6.00e-05 agctatggag gccagagg gaagtggcac chr16:50705723-50705803 27 7.38e-05 tacagttttt accacaag gtgtcgctgt chr5:173019233-173019313 15 7.38e-05 gcttctcttc accacaag gtggcactgt chr7:92418044-92418124 64 8.54e-05 aactatggag ggcagaag gcagtggga chr12:127661515-12766159 20 9.97e-05 caccctttct gccaaaag taaaattacc -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCAGAAG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:112962144-112962224 1.1e-05 61_[+5]_11 chr1:117437857-117437937 1.1e-05 53_[+5]_19 chr9:126590945-126591025 1.1e-05 54_[+5]_18 chr21:46248722-46248802 1.1e-05 59_[+5]_13 chr11:87049232-87049312 1.1e-05 67_[+5]_5 chr1:197694356-197694436 1.1e-05 63_[+5]_9 chr20:33784302-33784382 1.1e-05 50_[+5]_22 chr4:95348099-95348179 1.1e-05 62_[+5]_10 chr1:203064344-203064424 1.1e-05 37_[+5]_35 chr4:2134334-2134414 2.6e-05 64_[+5]_8 chr4:83945533-83945613 2.6e-05 37_[+5]_35 chr7:50286328-50286408 2.6e-05 58_[+5]_14 chr8:103689464-103689544 2.6e-05 47_[+5]_25 chr2:6971533-6971613 2.6e-05 25_[+5]_47 chr2:172386597-172386677 3.6e-05 11_[+5]_61 chr19:5515887-5515967 3.6e-05 23_[+5]_49 chr6:132244668-132244748 3.6e-05 24_[+5]_48 chr5:79016119-79016199 6e-05 72_[+5] chr6:170792674-170792754 6e-05 59_[+5]_13 chr6:27282015-27282095 6e-05 57_[+5]_15 chr5:131641274-131641354 6e-05 38_[+5]_34 chr9:138787219-138787299 6e-05 32_[+5]_40 chr16:50705723-50705803 7.4e-05 26_[+5]_46 chr5:173019233-173019313 7.4e-05 14_[+5]_58 chr7:92418044-92418124 8.5e-05 63_[+5]_9 chr12:127661515-12766159 0.0001 19_[+5]_53 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCAGAAG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GCCAGAAG width=8 seqs=26 chr2:112962144-112962224 ( 62) GCCAGAAG 1 chr1:117437857-117437937 ( 54) GCCAGAAG 1 chr9:126590945-126591025 ( 55) GCCAGAAG 1 chr21:46248722-46248802 ( 60) GCCAGAAG 1 chr11:87049232-87049312 ( 68) GCCAGAAG 1 chr1:197694356-197694436 ( 64) GCCAGAAG 1 chr20:33784302-33784382 ( 51) GCCAGAAG 1 chr4:95348099-95348179 ( 63) GCCAGAAG 1 chr1:203064344-203064424 ( 38) GCCAGAAG 1 chr4:2134334-2134414 ( 65) ACCAGAAG 1 chr4:83945533-83945613 ( 38) ACCAGAAG 1 chr7:50286328-50286408 ( 59) ACCAGAAG 1 chr8:103689464-103689544 ( 48) ACCAGAAG 1 chr2:6971533-6971613 ( 26) ACCAGAAG 1 chr2:172386597-172386677 ( 12) GCCACAAG 1 chr19:5515887-5515967 ( 24) GCCACAAG 1 chr6:132244668-132244748 ( 25) GCCACAAG 1 chr5:79016119-79016199 ( 73) GACAGAAG 1 chr6:170792674-170792754 ( 60) GACAGAAG 1 chr6:27282015-27282095 ( 58) GCCAGAGG 1 chr5:131641274-131641354 ( 39) GACAGAAG 1 chr9:138787219-138787299 ( 33) GCCAGAGG 1 chr16:50705723-50705803 ( 27) ACCACAAG 1 chr5:173019233-173019313 ( 15) ACCACAAG 1 chr7:92418044-92418124 ( 64) GGCAGAAG 1 chr12:127661515-12766159 ( 20) GCCAAAAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCAGAAG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 9.20831 E= 1.6e-006 -7 -1134 172 -1134 -129 198 -253 -1134 -1134 222 -1134 -1134 183 -1134 -1134 -1134 -287 -16 179 -1134 183 -1134 -1134 -1134 171 -1134 -153 -1134 -1134 -1134 217 -1134 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCAGAAG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 26 E= 1.6e-006 0.269231 0.000000 0.730769 0.000000 0.115385 0.846154 0.038462 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.038462 0.192308 0.769231 0.000000 1.000000 0.000000 0.000000 0.000000 0.923077 0.000000 0.076923 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCAGAAG MEME-5 regular expression -------------------------------------------------------------------------------- [GA]CCAGAAG -------------------------------------------------------------------------------- Time 17.99 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:21332920-21333000 8.04e-04 53_[+4(7.21e-05)]_19 chr2:38966829-38966909 1.50e-04 60_[+2(1.88e-05)]_12 chr7:18301875-18301955 9.75e-03 80 chr4:187641253-187641333 8.70e-01 80 chr1:203064344-203064424 1.53e-04 37_[+5(1.12e-05)]_[+2(1.88e-05)]_16_\ [+5(9.97e-05)]_3 chr4:95348099-95348179 1.05e-03 62_[+5(1.12e-05)]_10 chr11:77526058-77526138 1.09e-01 80 chr11:57386950-57387030 2.87e-02 4_[+3(1.81e-05)]_68 chr5:148648655-148648735 4.51e-01 80 chr6:125432546-125432626 1.68e-02 21_[+1(5.71e-05)]_51 chr20:49038318-49038398 2.60e-02 46_[+2(6.01e-05)]_26 chr1:222942697-222942777 3.72e-02 80 chr7:149163617-149163697 1.28e-03 41_[+4(9.96e-05)]_31 chr5:154066245-154066325 2.08e-01 80 chr3:12906933-12907013 5.71e-03 23_[+1(4.28e-05)]_49 chr1:55109554-55109634 6.17e-03 8_[+4(7.21e-05)]_64 chr20:33784302-33784382 2.81e-05 50_[+5(1.12e-05)]_[+2(1.88e-05)]_14 chr5:125980997-125981077 2.91e-05 1_[+3(3.19e-05)]_1_[+4(1.08e-05)]_\ 10_[+1(4.28e-05)]_26_[+3(6.98e-05)]_10 chrX:39909950-39910030 1.33e-02 10_[+2(6.01e-05)]_62 chr11:333338-333418 3.41e-01 80 chr7:99536066-99536146 4.03e-04 20_[+4(1.08e-05)]_21_[+1(9.99e-05)]_\ 23 chr9:134418657-134418737 3.20e-02 80 chr8:102768635-102768715 1.14e-02 8_[+2(1.88e-05)]_64 chr10:76576948-76577028 4.39e-03 80 chr19:14204110-14204190 4.25e-01 80 chr2:146172894-146172974 3.07e-05 3_[+3(1.81e-05)]_1_[+4(1.08e-05)]_\ 60 chr12:125249090-12524917 6.30e-02 80 chr9:138787219-138787299 1.31e-04 32_[+5(6.00e-05)]_40 chr7:101490622-101490702 1.87e-02 80 chr1:54399997-54400077 2.43e-03 6_[+3(4.56e-05)]_9_[+3(3.19e-05)]_\ 14_[+1(9.99e-05)]_27 chr1:180557401-180557481 1.84e-04 29_[+2(6.01e-05)]_7_[+1(4.28e-05)]_\ 28 chr2:145476068-145476148 2.49e-03 80 chr7:151008762-151008842 3.98e-02 80 chr8:130512900-130512980 4.24e-01 80 chr6:44027508-44027588 6.00e-03 55_[+3(6.98e-05)]_17 chr15:93493004-93493084 2.82e-03 38_[+1(4.28e-05)]_34 chr14:70107805-70107885 3.54e-02 80 chr1:11817281-11817361 9.53e-02 80 chr5:131641274-131641354 1.77e-03 38_[+5(6.00e-05)]_34 chr6:107106485-107106565 1.91e-03 4_[+4(1.08e-05)]_68 chr1:207051941-207052021 1.50e-01 80 chr2:6971533-6971613 1.22e-03 25_[+5(2.55e-05)]_47 chr16:11312571-11312651 2.84e-02 80 chr1:92212433-92212513 3.28e-01 80 chr11:109949769-10994984 6.10e-01 80 chr15:82285008-82285088 2.77e-02 80 chr9:138921079-138921159 4.46e-03 60_[+1(4.28e-05)]_12 chr10:50474070-50474150 1.05e-01 80 chr5:149155503-149155583 2.10e-01 80 chr3:169929636-169929716 2.21e-03 6_[+2(4.84e-05)]_66 chr7:75272371-75272451 1.99e-02 80 chr7:77450482-77450562 3.66e-04 6_[+4(3.31e-05)]_44_[+3(1.81e-05)]_\ 14 chr12:127661515-12766159 3.88e-02 19_[+5(9.97e-05)]_53 chr7:29871482-29871562 7.66e-02 27_[+2(6.01e-05)]_45 chr1:91344981-91345061 3.18e-03 4_[+4(9.96e-05)]_22_[+1(9.99e-05)]_\ 38 chr19:55439851-55439931 9.73e-05 49_[+2(1.88e-05)]_23 chr19:40531974-40532054 1.56e-03 18_[+1(9.99e-05)]_13_[+3(1.81e-05)]_\ 33 chr1:168421736-168421816 8.57e-01 80 chr15:81288753-81288833 6.20e-01 80 chr5:121425393-121425473 2.57e-01 80 chr7:92418044-92418124 1.04e-04 11_[+2(4.84e-05)]_44_[+5(8.54e-05)]_\ 9 chr7:2068519-2068599 2.69e-02 80 chr18:9975788-9975868 2.19e-03 12_[+3(1.81e-05)]_8_[+3(5.61e-05)]_\ 13_[+1(9.99e-05)]_23 chr7:97726479-97726559 1.84e-04 23_[+4(1.08e-05)]_22_[+1(9.99e-05)]_\ 19 chr4:88164743-88164823 6.59e-02 80 chr1:227122260-227122340 8.51e-01 80 chr7:10798910-10798990 6.75e-04 51_[+1(4.28e-05)]_21 chr8:144751381-144751461 3.24e-06 41_[+1(4.28e-05)]_15_[+4(1.08e-05)]_\ 8 chr5:118593469-118593549 1.98e-03 24_[+2(1.88e-05)]_48 chr6:118895571-118895651 4.63e-03 23_[+1(4.28e-05)]_49 chr12:106676300-10667638 2.09e-01 80 chr5:37775136-37775216 2.79e-01 80 chr1:227530281-227530361 4.05e-03 38_[+1(5.71e-05)]_34 chr6:159390345-159390425 3.68e-04 26_[+4(7.21e-05)]_22_[+1(9.99e-05)]_\ 16 chr2:112734953-112735033 1.29e-02 18_[+4(7.21e-05)]_54 chr10:1024902-1024982 2.63e-02 34_[+1(9.99e-05)]_38 chr3:136404904-136404984 2.02e-02 80 chr9:130288231-130288311 1.17e-01 80 chr1:196504985-196505065 5.27e-02 80 chr1:197694356-197694436 4.36e-05 54_[+2(3.36e-05)]_1_[+5(1.12e-05)]_\ 9 chr6:132244668-132244748 5.11e-02 24_[+5(3.63e-05)]_48 chr20:36871392-36871472 1.78e-01 80 chr11:17393326-17393406 1.24e-01 80 chr12:1856935-1857015 3.05e-02 80 chr1:53008104-53008184 2.67e-01 80 chr2:169772283-169772363 5.88e-03 49_[+2(6.01e-05)]_23 chr7:106664110-106664190 1.90e-01 80 chr8:145838892-145838972 1.25e-02 80 chr8:127288166-127288246 8.94e-02 80 chr11:93708073-93708153 1.88e-04 12_[+3(3.19e-05)]_1_[+4(2.46e-05)]_\ 51 chr6:34526126-34526206 4.34e-03 80 chr5:148990496-148990576 3.02e-02 47_[+1(9.99e-05)]_25 chr5:173019233-173019313 1.96e-03 14_[+5(7.38e-05)]_58 chr1:162446571-162446651 5.60e-02 80 chr6:43424688-43424768 4.49e-03 [+3(4.56e-05)]_43_[+1(9.99e-05)]_21 chr7:103054040-103054120 6.93e-01 80 chr7:5134452-5134532 2.09e-04 34_[+5(2.55e-05)]_38 chr6:159326497-159326577 1.30e-03 54_[+2(1.88e-05)]_18 chr3:157918933-157919013 1.28e-03 28_[+3(3.19e-05)]_44 chr6:90996755-90996835 1.52e-01 80 chr1:117286288-117286368 4.25e-01 80 chr20:726503-726583 2.52e-02 80 chr9:101127645-101127725 1.75e-01 80 chr2:241471621-241471701 5.38e-04 47_[+2(1.88e-05)]_25 chr9:135572835-135572915 2.83e-02 51_[+2(1.88e-05)]_21 chr6:108563629-108563709 1.35e-04 57_[+2(1.88e-05)]_15 chr9:132275702-132275782 2.32e-03 1_[+3(1.81e-05)]_30_[+1(9.99e-05)]_\ 33 chr20:32535674-32535754 3.66e-03 80 chr11:87049232-87049312 2.23e-04 67_[+5(1.12e-05)]_5 chr3:10287144-10287224 8.84e-04 18_[+4(3.31e-05)]_12_[+1(4.28e-05)]_\ 34 chr6:27282015-27282095 7.67e-05 48_[+2(1.88e-05)]_1_[+5(6.00e-05)]_\ 15 chr7:65730743-65730823 6.27e-04 80 chr1:244739732-244739812 1.26e-02 13_[+1(4.28e-05)]_42_[+1(4.28e-05)]_\ 9 chr10:71309916-71309996 7.18e-03 80 chr8:23457940-23458020 8.15e-05 8_[+3(1.81e-05)]_1_[+4(2.46e-05)]_\ 22_[+1(9.99e-05)]_25 chr1:236545011-236545091 4.59e-02 80 chr2:113758157-113758237 1.70e-02 5_[+4(7.21e-05)]_67 chr8:91151332-91151412 9.92e-03 57_[+2(7.82e-05)]_15 chr21:31032850-31032930 1.78e-01 80 chr17:37203401-37203481 1.72e-02 26_[+1(4.28e-05)]_46 chr10:5561157-5561237 5.19e-01 80 chr1:234821938-234822018 1.16e-02 44_[+2(7.82e-05)]_28 chr12:117001223-11700130 2.44e-02 12_[+3(1.81e-05)]_60 chr3:14946698-14946778 4.95e-04 4_[+3(5.61e-05)]_1_[+4(7.21e-05)]_\ 59 chr2:127433348-127433428 5.25e-01 80 chr3:33740953-33741033 1.14e-01 80 chr3:150393500-150393580 4.16e-03 21_[+3(1.81e-05)]_51 chr19:8917505-8917585 6.22e-03 18_[+4(8.59e-05)]_54 chr7:86957778-86957858 2.85e-02 80 chr6:149419971-149420051 5.73e-01 80 chr5:10740671-10740751 8.57e-04 32_[+4(7.21e-05)]_5_[+2(1.88e-05)]_\ 27 chr6:163929139-163929219 6.65e-01 80 chr7:35731732-35731812 1.93e-01 80 chr21:34739916-34739996 3.28e-03 17_[+1(4.28e-05)]_55 chr7:158500394-158500474 9.75e-03 80 chr18:77782809-77782889 8.13e-02 80 chr14:100621486-10062156 7.76e-02 80 chr1:114389411-114389491 1.24e-01 80 chr1:155613161-155613241 3.42e-01 80 chr11:61766908-61766988 6.42e-03 25_[+1(9.99e-05)]_47 chr7:156526559-156526639 1.05e-02 60_[+2(3.36e-05)]_12 chr7:138114449-138114529 7.32e-04 45_[+1(4.28e-05)]_27 chr2:28378655-28378735 2.29e-02 80 chr1:53603581-53603661 9.93e-02 80 chr4:123410359-123410439 3.55e-01 80 chr11:59936920-59937000 6.02e-01 80 chr2:109486664-109486744 3.75e-02 80 chr5:134318134-134318214 9.60e-02 1_[+2(6.01e-05)]_71 chr6:157927071-157927151 2.35e-01 80 chr7:66717092-66717172 3.88e-04 28_[+1(4.28e-05)]_44 chr12:132678763-13267884 1.64e-02 80 chr17:59697066-59697146 1.40e-03 59_[+2(1.88e-05)]_13 chr1:224359011-224359091 1.55e-03 10_[+4(1.08e-05)]_[+3(5.61e-05)]_54 chr2:97043201-97043281 2.66e-05 8_[+4(1.08e-05)]_42_[+3(8.80e-05)]_\ 14 chr8:145143362-145143442 4.64e-03 41_[+1(4.28e-05)]_31 chr1:26697614-26697694 8.94e-03 80 chr22:50161046-50161126 2.69e-01 80 chr9:130285826-130285906 9.80e-02 80 chr6:170792674-170792754 1.37e-03 59_[+5(6.00e-05)]_13 chr1:167946639-167946719 1.18e-02 21_[+3(1.81e-05)]_51 chr21:46248722-46248802 2.43e-03 59_[+5(1.12e-05)]_13 chr6:150087455-150087535 8.57e-01 80 chr6:24431420-24431500 1.21e-01 80 chr7:774012-774092 7.29e-01 80 chr20:62776966-62777046 2.34e-02 80 chr2:43096165-43096245 2.20e-01 80 chr7:64869085-64869165 2.71e-01 80 chr6:13942342-13942422 9.28e-02 23_[+3(1.81e-05)]_49 chr2:174163436-174163516 5.52e-01 80 chr9:132064367-132064447 6.69e-02 80 chr10:72408397-72408477 4.40e-01 80 chr22:19254231-19254311 1.06e-01 80 chr12:51193893-51193973 3.23e-02 80 chr3:5490660-5490740 2.03e-03 29_[+1(9.99e-05)]_43 chr16:58394126-58394206 3.42e-01 80 chr11:76487668-76487748 7.30e-04 8_[+4(1.08e-05)]_22_[+1(5.71e-05)]_\ 34 chr16:30108409-30108489 6.46e-03 34_[+1(4.28e-05)]_38 chr7:155441546-155441626 7.18e-02 80 chr8:103689464-103689544 9.91e-03 47_[+5(2.55e-05)]_25 chr17:75163948-75164028 1.46e-03 36_[+1(4.28e-05)]_36 chr4:123964316-123964396 8.49e-04 19_[+3(4.56e-05)]_31_[+1(7.14e-05)]_\ 14 chr16:85386795-85386875 3.94e-01 80 chr9:90282251-90282331 5.96e-02 80 chr5:147978971-147979051 7.88e-04 31_[+1(7.14e-05)]_17_[+2(1.88e-05)]_\ 16 chr8:42344138-42344218 1.23e-03 42_[+1(9.99e-05)]_14_[+3(3.19e-05)]_\ 8 chr6:39139433-39139513 4.88e-03 68_[+2(6.01e-05)]_4 chr9:126590945-126591025 4.63e-03 54_[+5(1.12e-05)]_18 chr7:50286328-50286408 4.03e-07 20_[+3(3.19e-05)]_30_[+5(2.55e-05)]_\ [+2(1.88e-05)]_6 chr1:224531442-224531522 1.94e-02 40_[+1(9.99e-05)]_32 chr1:154268239-154268319 9.36e-04 63_[+2(1.88e-05)]_9 chr7:2064961-2065041 1.60e-01 80 chr21:38774710-38774790 4.14e-04 18_[+3(1.81e-05)]_1_[+4(1.08e-05)]_\ [+3(1.81e-05)]_37 chr1:212032893-212032973 3.89e-01 80 chr3:45132475-45132555 4.80e-01 80 chr10:29134084-29134164 1.07e-01 80 chr20:48162253-48162333 8.54e-02 80 chr7:149408057-149408137 1.49e-03 69_[+2(1.88e-05)]_3 chr3:72274071-72274151 1.87e-03 16_[+4(7.21e-05)]_6_[+1(9.99e-05)]_\ 42 chr6:157346782-157346862 2.41e-02 17_[+3(1.81e-05)]_55 chr16:50705723-50705803 2.61e-02 26_[+5(7.38e-05)]_46 chr1:117437857-117437937 1.85e-04 53_[+5(1.12e-05)]_[+2(1.88e-05)]_11 chr10:5207848-5207928 1.25e-01 80 chr3:196710224-196710304 1.08e-02 [+4(9.96e-05)]_10_[+1(5.71e-05)]_54 chr10:75077154-75077234 1.37e-02 5_[+3(1.81e-05)]_67 chr7:12741181-12741261 4.45e-04 8_[+3(1.81e-05)]_14_[+1(9.99e-05)]_\ 42 chr4:83945533-83945613 1.30e-03 37_[+5(2.55e-05)]_35 chr6:158379240-158379320 8.29e-03 80 chr5:79016119-79016199 3.55e-04 63_[+2(1.88e-05)]_1_[+5(6.00e-05)] chr1:52682731-52682811 1.09e-04 39_[+1(4.28e-05)]_33 chr1:11566126-11566206 9.06e-04 7_[+3(4.56e-05)]_1_[+4(9.96e-05)]_\ 56 chr3:158453234-158453314 2.09e-02 30_[+2(6.01e-05)]_42 chr1:26595781-26595861 1.18e-02 30_[+1(4.28e-05)]_42 chr22:25112731-25112811 8.93e-03 17_[+1(4.28e-05)]_43_[+3(8.80e-05)]_\ 4 chr20:40228636-40228716 1.35e-02 29_[+1(4.28e-05)]_43 chr12:111742523-11174260 2.51e-01 80 chr1:12447901-12447981 4.51e-01 80 chr11:70597404-70597484 1.21e-03 80 chr13:41722987-41723067 3.08e-01 80 chr2:158579286-158579366 7.53e-03 80 chr4:56441845-56441925 6.76e-04 14_[+2(4.84e-05)]_27_[+1(1.43e-05)]_\ 23 chr2:112962144-112962224 4.59e-05 61_[+5(1.12e-05)]_11 chr21:46242948-46243028 6.57e-02 80 chr4:2134334-2134414 1.67e-05 64_[+5(2.55e-05)]_[+2(1.88e-05)] chr11:74588374-74588454 5.11e-01 80 chr11:69239647-69239727 4.47e-01 80 chr7:138054719-138054799 4.58e-02 80 chr7:127835068-127835148 1.22e-02 28_[+1(9.99e-05)]_22_[+4(8.59e-05)]_\ 14 chr2:44537575-44537655 4.77e-02 80 chr7:106677142-106677222 3.36e-02 80 chr16:11301656-11301736 1.49e-01 80 chr17:75170840-75170920 1.58e-02 80 chr2:25117756-25117836 1.63e-02 80 chr8:8293290-8293370 3.13e-04 1_[+3(3.19e-05)]_1_[+4(9.96e-05)]_\ [+3(1.81e-05)]_54 chr12:94816061-94816141 8.71e-03 44_[+1(4.28e-05)]_28 chr1:117291116-117291196 4.10e-03 15_[+1(4.28e-05)]_57 chr19:5515887-5515967 4.53e-03 23_[+5(3.63e-05)]_49 chr19:970803-970883 2.27e-01 80 chr12:96738210-96738290 6.59e-02 80 chr19:8134385-8134465 1.12e-02 51_[+4(3.31e-05)]_21 chr7:131021797-131021877 6.93e-04 8_[+4(2.46e-05)]_[+3(1.81e-05)]_56 chr1:68429111-68429191 5.09e-03 39_[+1(4.28e-05)]_33 chr5:452335-452415 1.75e-01 80 chr19:6292188-6292268 2.80e-01 80 chr2:6985643-6985723 1.20e-01 80 chr2:172386597-172386677 1.43e-02 11_[+5(3.63e-05)]_61 chr10:72139479-72139559 4.69e-02 80 chr1:200948903-200948983 2.41e-02 80 chr7:75436042-75436122 4.71e-02 80 chr2:24643414-24643494 1.90e-01 80 chr19:3467910-3467990 6.49e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n09.farnam.hpc.yale.internal ********************************************************************************