******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/K562/fasta/RankLinear0.6_40/BRD4.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr9:91925278-91925358 1.0000 80 chr18:3653420-3653500 1.0000 80 chr6:168257265-168257345 1.0000 80 chr3:176914548-176914628 1.0000 80 chr1:228270832-228270912 1.0000 80 chr15:69110130-69110210 1.0000 80 chr7:20260060-20260140 1.0000 80 chr14:100842215-10084229 1.0000 80 chrX:123094868-123094948 1.0000 80 chr16:70322870-70322950 1.0000 80 chr1:26453632-26453712 1.0000 80 chr1:160231698-160231778 1.0000 80 chr6:135643939-135644019 1.0000 80 chr18:3602833-3602913 1.0000 80 chr7:106208904-106208984 1.0000 80 chr11:61735857-61735937 1.0000 80 chr19:18393193-18393273 1.0000 80 chr16:30661584-30661664 1.0000 80 chr6:12011213-12011293 1.0000 80 chr9:86594851-86594931 1.0000 80 chr5:39202409-39202489 1.0000 80 chr10:21815708-21815788 1.0000 80 chr21:38445069-38445149 1.0000 80 chr18:3596523-3596603 1.0000 80 chr3:5471390-5471470 1.0000 80 chr9:132650031-132650111 1.0000 80 chr22:21997053-21997133 1.0000 80 chr1:154193735-154193815 1.0000 80 chrX:123095123-123095203 1.0000 80 chr12:54412372-54412452 1.0000 80 chr21:36577451-36577531 1.0000 80 chr18:3606040-3606120 1.0000 80 chr4:10182210-10182290 1.0000 80 chr9:131037693-131037773 1.0000 80 chr2:37789251-37789331 1.0000 80 chr17:1620202-1620282 1.0000 80 chr6:26200220-26200300 1.0000 80 chr11:122933724-12293380 1.0000 80 chr16:47496624-47496704 1.0000 80 chr6:73268981-73269061 1.0000 80 chr18:3596135-3596215 1.0000 80 chr19:41770628-41770708 1.0000 80 chrX:48659503-48659583 1.0000 80 chr1:27113997-27114077 1.0000 80 chr1:24970220-24970300 1.0000 80 chr16:87812291-87812371 1.0000 80 chr22:38901999-38902079 1.0000 80 chr6:26021023-26021103 1.0000 80 chr7:130645452-130645532 1.0000 80 chr19:52050544-52050624 1.0000 80 chr18:9876938-9877018 1.0000 80 chr11:118443476-11844355 1.0000 80 chr16:28834910-28834990 1.0000 80 chr18:3603917-3603997 1.0000 80 chr11:61559777-61559857 1.0000 80 chr2:160472439-160472519 1.0000 80 chr5:102455374-102455454 1.0000 80 chr1:206845913-206845993 1.0000 80 chr1:160510664-160510744 1.0000 80 chr4:10183755-10183835 1.0000 80 chr9:110046106-110046186 1.0000 80 chr20:45987538-45987618 1.0000 80 chr3:196066128-196066208 1.0000 80 chr22:35795427-35795507 1.0000 80 chr8:30602222-30602302 1.0000 80 chr19:39340332-39340412 1.0000 80 chr6:7698372-7698452 1.0000 80 chr3:31573262-31573342 1.0000 80 chr22:21996715-21996795 1.0000 80 chr17:41277976-41278056 1.0000 80 chr1:234859331-234859411 1.0000 80 chr7:151622690-151622770 1.0000 80 chr6:28533798-28533878 1.0000 80 chr10:74033101-74033181 1.0000 80 chr17:46703116-46703196 1.0000 80 chr8:38240283-38240363 1.0000 80 chr19:52773159-52773239 1.0000 80 chr6:8102245-8102325 1.0000 80 chr2:136499752-136499832 1.0000 80 chr6:147205255-147205335 1.0000 80 chr6:32938151-32938231 1.0000 80 chr22:29664475-29664555 1.0000 80 chr9:100743058-100743138 1.0000 80 chr3:5229877-5229957 1.0000 80 chr6:24722154-24722234 1.0000 80 chr17:49198883-49198963 1.0000 80 chr21:43299796-43299876 1.0000 80 chr20:34329799-34329879 1.0000 80 chr19:52050787-52050867 1.0000 80 chr19:54641675-54641755 1.0000 80 chr22:19706262-19706342 1.0000 80 chr6:42751626-42751706 1.0000 80 chr1:154974348-154974428 1.0000 80 chr6:155055009-155055089 1.0000 80 chr11:122933509-12293358 1.0000 80 chr1:24018681-24018761 1.0000 80 chr11:59313578-59313658 1.0000 80 chr12:57915311-57915391 1.0000 80 chr3:9833900-9833980 1.0000 80 chr19:58897920-58898000 1.0000 80 chr9:132245790-132245870 1.0000 80 chr7:16309062-16309142 1.0000 80 chr22:20105574-20105654 1.0000 80 chr10:93367962-93368042 1.0000 80 chr12:57848623-57848703 1.0000 80 chr5:43008403-43008483 1.0000 80 chr12:74931808-74931888 1.0000 80 chr2:174829859-174829939 1.0000 80 chr1:113161728-113161808 1.0000 80 chr18:3604930-3605010 1.0000 80 chr17:57882742-57882822 1.0000 80 chr1:38412382-38412462 1.0000 80 chr2:64068460-64068540 1.0000 80 chr3:9439858-9439938 1.0000 80 chr6:42751423-42751503 1.0000 80 chr6:28304049-28304129 1.0000 80 chr6:32937324-32937404 1.0000 80 chr5:17401006-17401086 1.0000 80 chr1:160509702-160509782 1.0000 80 chr6:27862796-27862876 1.0000 80 chr15:49447592-49447672 1.0000 80 chr3:47204838-47204918 1.0000 80 chr17:38804281-38804361 1.0000 80 chr1:31242473-31242553 1.0000 80 chr6:30684802-30684882 1.0000 80 chrX:11359818-11359898 1.0000 80 chr4:119756637-119756717 1.0000 80 chr12:93767802-93767882 1.0000 80 chr1:245027477-245027557 1.0000 80 chr6:105405417-105405497 1.0000 80 chr1:26396541-26396621 1.0000 80 chr5:179126399-179126479 1.0000 80 chr1:245134554-245134634 1.0000 80 chr9:132647549-132647629 1.0000 80 chr1:52345167-52345247 1.0000 80 chr6:8065034-8065114 1.0000 80 chr12:53773065-53773145 1.0000 80 chr3:169482378-169482458 1.0000 80 chr6:3355607-3355687 1.0000 80 chr17:80056992-80057072 1.0000 80 chr2:178130094-178130174 1.0000 80 chr6:13575009-13575089 1.0000 80 chr1:156630613-156630693 1.0000 80 chr12:123869068-12386914 1.0000 80 chr10:74081270-74081350 1.0000 80 chr11:63974727-63974807 1.0000 80 chr18:9915210-9915290 1.0000 80 chr17:57915779-57915859 1.0000 80 chr6:49604184-49604264 1.0000 80 chr10:32635786-32635866 1.0000 80 chr8:27695829-27695909 1.0000 80 chr6:26205375-26205455 1.0000 80 chr10:93368449-93368529 1.0000 80 chr22:21213384-21213464 1.0000 80 chr4:775297-775377 1.0000 80 chr12:53400620-53400700 1.0000 80 chr19:51161023-51161103 1.0000 80 chr2:58958418-58958498 1.0000 80 chr11:32454943-32455023 1.0000 80 chr1:184943183-184943263 1.0000 80 chr13:45915102-45915182 1.0000 80 chr10:94516848-94516928 1.0000 80 chr7:139025785-139025865 1.0000 80 chr12:125406332-12540641 1.0000 80 chr17:46662584-46662664 1.0000 80 chr14:102177426-10217750 1.0000 80 chr6:28912360-28912440 1.0000 80 chr10:17243210-17243290 1.0000 80 chr12:113860377-11386045 1.0000 80 chr6:111805536-111805616 1.0000 80 chr21:34914614-34914694 1.0000 80 chr19:44259401-44259481 1.0000 80 chr16:22207024-22207104 1.0000 80 chr19:29095956-29096036 1.0000 80 chr20:1306182-1306262 1.0000 80 chr2:19986510-19986590 1.0000 80 chr6:27805524-27805604 1.0000 80 chr1:113162065-113162145 1.0000 80 chr19:953007-953087 1.0000 80 chr22:20105776-20105856 1.0000 80 chr3:19987916-19987996 1.0000 80 chr1:16212518-16212598 1.0000 80 chr6:43884431-43884511 1.0000 80 chr1:51443409-51443489 1.0000 80 chr6:26331742-26331822 1.0000 80 chr19:45682517-45682597 1.0000 80 chr18:3625116-3625196 1.0000 80 chr15:79165504-79165584 1.0000 80 chr9:132250431-132250511 1.0000 80 chrX:110924550-110924630 1.0000 80 chr5:68463146-68463226 1.0000 80 chr11:78036497-78036577 1.0000 80 chr1:226187673-226187753 1.0000 80 chr4:40240189-40240269 1.0000 80 chr1:234746256-234746336 1.0000 80 chr10:24858826-24858906 1.0000 80 chr5:180633890-180633970 1.0000 80 chr19:8455362-8455442 1.0000 80 chr6:150489317-150489397 1.0000 80 chr1:193026930-193027010 1.0000 80 chr17:49338057-49338137 1.0000 80 chr11:16760330-16760410 1.0000 80 chrX:153237091-153237171 1.0000 80 chr12:56694656-56694736 1.0000 80 chr7:26239842-26239922 1.0000 80 chr12:57623744-57623824 1.0000 80 chr2:20102078-20102158 1.0000 80 chr11:747668-747748 1.0000 80 chr4:48833493-48833573 1.0000 80 chr11:65186829-65186909 1.0000 80 chr11:118662050-11866213 1.0000 80 chr12:54719076-54719156 1.0000 80 chr16:69165705-69165785 1.0000 80 chr17:33308027-33308107 1.0000 80 chr5:43556578-43556658 1.0000 80 chr2:25195235-25195315 1.0000 80 chr1:211432041-211432121 1.0000 80 chr20:45989230-45989310 1.0000 80 chr11:59327818-59327898 1.0000 80 chr1:225965775-225965855 1.0000 80 chr11:65187028-65187108 1.0000 80 chr10:5854830-5854910 1.0000 80 chr11:118662294-11866237 1.0000 80 chr1:203595329-203595409 1.0000 80 chr2:85839412-85839492 1.0000 80 chr7:104654208-104654288 1.0000 80 chr1:249120748-249120828 1.0000 80 chr3:13461156-13461236 1.0000 80 chr17:80057245-80057325 1.0000 80 chr1:62901573-62901653 1.0000 80 chr10:6516152-6516232 1.0000 80 chr22:21271891-21271971 1.0000 80 chr22:19706462-19706542 1.0000 80 chr12:53400421-53400501 1.0000 80 chr10:73473142-73473222 1.0000 80 chr6:90062314-90062394 1.0000 80 chrX:54070502-54070582 1.0000 80 chr1:227127012-227127092 1.0000 80 chr19:56166601-56166681 1.0000 80 chr16:30621352-30621432 1.0000 80 chr22:41487830-41487910 1.0000 80 chr1:174968273-174968353 1.0000 80 chr18:3447874-3447954 1.0000 80 chr17:30771686-30771766 1.0000 80 chr12:123850062-12385014 1.0000 80 chr1:26799142-26799222 1.0000 80 chr19:47615973-47616053 1.0000 80 chrX:65235541-65235621 1.0000 80 chr1:67519692-67519772 1.0000 80 chr15:63795919-63795999 1.0000 80 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/K562/inference_raw/MEME/RankLinear0.6_40_BRD4/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/K562/fasta/RankLinear0.6_40/BRD4.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 20000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 20000 norand= no csites= 1000 Letter frequencies in dataset: A 0.219 C 0.271 G 0.282 T 0.228 Background letter frequencies (from file dataset with add-one prior applied): A 0.219 C 0.271 G 0.282 T 0.228 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF ARTAAAAA MEME-1 width = 8 sites = 23 llr = 201 E-value = 3.0e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif ARTAAAAA MEME-1 Description -------------------------------------------------------------------------------- Simplified A a61a997a pos.-specific C ::::1::: probability G :43::13: matrix T ::6::::: bits 2.2 * * 2.0 * * * 1.8 * * * * 1.5 * *** * Relative 1.3 * *** * Entropy 1.1 ** ***** (12.6 bits) 0.9 ** ***** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AATAAAAA consensus GG G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARTAAAAA MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr20:45989230-45989310 23 5.51e-06 GCAATGAGCT AATAAAAA TAGATTAAAA chr12:93767802-93767882 59 5.51e-06 gctaacactc aataaAAA AATAGCCATT chr17:49198883-49198963 21 5.51e-06 gttttgggat aataaaaa tgttctaaaa chr19:52050544-52050624 31 1.26e-05 ggagtttata agtaaaaa tctttaaaca chr1:26453632-26453712 3 1.94e-05 aa aagaaaaa attcatcaag chr12:57848623-57848703 24 2.65e-05 CAGTGCTAGA AATAAAGA GACCAGAATT chr10:21815708-21815788 52 2.65e-05 TACAGGAGGA AATAAAGA GCGAGGAGAT chr6:3355607-3355687 65 3.18e-05 CTGGGTCGAG AAAAAAAA TCTCCATG chr4:40240189-40240269 63 4.06e-05 TGGTAGAAAG AGGAAAAA GGGCAAGAGC chr9:132250431-132250511 73 4.06e-05 TGAGAACGGG AGGAAAAA chr18:3603917-3603997 36 4.06e-05 GAAAAGAGGC AGGAAAAA AGTTCCTTTG chr3:19987916-19987996 24 4.97e-05 cgtttagtac agtaaaga gcgaagggaa chr18:9876938-9877018 46 4.97e-05 TTCTCTCTGG AGTAAAGA TTGGAAGGAA chr1:52345167-52345247 33 6.53e-05 ATGTGACGGA AATACAAA CATAAATGAA chr6:73268981-73269061 51 6.53e-05 ggtaattacc aagaaaga tagtgctgct chr16:70322870-70322950 27 6.53e-05 CACACCGAGA AATACAAA CTGTTTTACA chr6:150489317-150489397 54 7.21e-05 ctctcatggg agaaaaaa atcccttgat chr7:26239842-26239922 50 8.60e-05 TTAGAAAGGG AATAAGAA TTCCCGCCTC chr1:26396541-26396621 2 8.60e-05 G AAAAAAGA AGAGGCCTTA chr21:36577451-36577531 39 8.60e-05 TCTGGCTTTT AATAAGAA CGATTAACAA chr3:31573262-31573342 51 1.06e-04 CGCAATTCGG AGTACAAA CGAAAAAGGG chr18:3596135-3596215 8 1.06e-04 CAGGAGC AGGAAAGA ACAtttttct chr5:17401006-17401086 55 1.48e-04 GTGTTTGCTG AATGAAAA TTTGTAGCAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARTAAAAA MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr20:45989230-45989310 5.5e-06 22_[+1]_50 chr12:93767802-93767882 5.5e-06 58_[+1]_14 chr17:49198883-49198963 5.5e-06 20_[+1]_52 chr19:52050544-52050624 1.3e-05 30_[+1]_42 chr1:26453632-26453712 1.9e-05 2_[+1]_70 chr12:57848623-57848703 2.7e-05 23_[+1]_49 chr10:21815708-21815788 2.7e-05 51_[+1]_21 chr6:3355607-3355687 3.2e-05 64_[+1]_8 chr4:40240189-40240269 4.1e-05 62_[+1]_10 chr9:132250431-132250511 4.1e-05 72_[+1] chr18:3603917-3603997 4.1e-05 35_[+1]_37 chr3:19987916-19987996 5e-05 23_[+1]_49 chr18:9876938-9877018 5e-05 45_[+1]_27 chr1:52345167-52345247 6.5e-05 32_[+1]_40 chr6:73268981-73269061 6.5e-05 50_[+1]_22 chr16:70322870-70322950 6.5e-05 26_[+1]_46 chr6:150489317-150489397 7.2e-05 53_[+1]_19 chr7:26239842-26239922 8.6e-05 49_[+1]_23 chr1:26396541-26396621 8.6e-05 1_[+1]_71 chr21:36577451-36577531 8.6e-05 38_[+1]_34 chr3:31573262-31573342 0.00011 50_[+1]_22 chr18:3596135-3596215 0.00011 7_[+1]_65 chr5:17401006-17401086 0.00015 54_[+1]_18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARTAAAAA MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ARTAAAAA width=8 seqs=23 chr20:45989230-45989310 ( 23) AATAAAAA 1 chr12:93767802-93767882 ( 59) AATAAAAA 1 chr17:49198883-49198963 ( 21) AATAAAAA 1 chr19:52050544-52050624 ( 31) AGTAAAAA 1 chr1:26453632-26453712 ( 3) AAGAAAAA 1 chr12:57848623-57848703 ( 24) AATAAAGA 1 chr10:21815708-21815788 ( 52) AATAAAGA 1 chr6:3355607-3355687 ( 65) AAAAAAAA 1 chr4:40240189-40240269 ( 63) AGGAAAAA 1 chr9:132250431-132250511 ( 73) AGGAAAAA 1 chr18:3603917-3603997 ( 36) AGGAAAAA 1 chr3:19987916-19987996 ( 24) AGTAAAGA 1 chr18:9876938-9877018 ( 46) AGTAAAGA 1 chr1:52345167-52345247 ( 33) AATACAAA 1 chr6:73268981-73269061 ( 51) AAGAAAGA 1 chr16:70322870-70322950 ( 27) AATACAAA 1 chr6:150489317-150489397 ( 54) AGAAAAAA 1 chr7:26239842-26239922 ( 50) AATAAGAA 1 chr1:26396541-26396621 ( 2) AAAAAAGA 1 chr21:36577451-36577531 ( 39) AATAAGAA 1 chr3:31573262-31573342 ( 51) AGTACAAA 1 chr18:3596135-3596215 ( 8) AGGAAAGA 1 chr5:17401006-17401086 ( 55) AATGAAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARTAAAAA MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.5229 E= 3.0e+002 219 -1117 -1117 -1117 147 -1117 47 -1117 -75 -1117 -11 142 213 -1117 -269 -1117 199 -106 -1117 -1117 206 -1117 -170 -1117 167 -1117 11 -1117 219 -1117 -1117 -1117 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARTAAAAA MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 23 E= 3.0e+002 1.000000 0.000000 0.000000 0.000000 0.608696 0.000000 0.391304 0.000000 0.130435 0.000000 0.260870 0.608696 0.956522 0.000000 0.043478 0.000000 0.869565 0.130435 0.000000 0.000000 0.913043 0.000000 0.086957 0.000000 0.695652 0.000000 0.304348 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARTAAAAA MEME-1 regular expression -------------------------------------------------------------------------------- A[AG][TG]AAA[AG]A -------------------------------------------------------------------------------- Time 5.00 secs. ******************************************************************************** ******************************************************************************** MOTIF AAAATAWT MEME-2 width = 8 sites = 12 llr = 117 E-value = 3.7e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAAATAWT MEME-2 Description -------------------------------------------------------------------------------- Simplified A a88a:84: pos.-specific C ::2:::1: probability G :::::::: matrix T :2::a25a bits 2.2 * ** * 2.0 * ** * 1.8 * ** * 1.5 ****** * Relative 1.3 ****** * Entropy 1.1 ****** * (14.0 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AAAATATT consensus A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAWT MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:226187673-226187753 46 5.97e-06 CTCTGTTTTC AAAATATT TCACAGCAAG chr18:3604930-3605010 33 5.97e-06 tttgtaggtc AAAATATT TGGAGAAATA chr6:26331742-26331822 45 1.17e-05 CTGATTCATG AAAATAAT TTCGGTACTG chr10:21815708-21815788 28 1.17e-05 TGGAGAGTTT AAAATAAT AGCATTTACA chr18:3653420-3653500 5 1.17e-05 TTGC AAAATAAT CAAAGCATTG chr11:78036497-78036577 46 2.41e-05 GGCTCTATTA ATAATATT GAACAACACC chr1:26396541-26396621 63 2.41e-05 TTGTCCCCCC AAAATTTT GCTGAGCACT chr1:26453632-26453712 70 2.41e-05 tacttcaaga aaaatttt aTT chr11:16760330-16760410 63 3.61e-05 GACGATGTAA ATAATAAT GGCGGAGTGG chr19:52050544-52050624 45 4.35e-05 aaaatcttta aacatatt tcctagcttg chr2:37789251-37789331 4 5.77e-05 ACA AAAATACT ACATGAGGAA chr3:176914548-176914628 66 5.77e-05 TTTCGGGGAC AACATAAT TAGGGTG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAWT MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:226187673-226187753 6e-06 45_[+2]_27 chr18:3604930-3605010 6e-06 32_[+2]_40 chr6:26331742-26331822 1.2e-05 44_[+2]_28 chr10:21815708-21815788 1.2e-05 27_[+2]_45 chr18:3653420-3653500 1.2e-05 4_[+2]_68 chr11:78036497-78036577 2.4e-05 45_[+2]_27 chr1:26396541-26396621 2.4e-05 62_[+2]_10 chr1:26453632-26453712 2.4e-05 69_[+2]_3 chr11:16760330-16760410 3.6e-05 62_[+2]_10 chr19:52050544-52050624 4.3e-05 44_[+2]_28 chr2:37789251-37789331 5.8e-05 3_[+2]_69 chr3:176914548-176914628 5.8e-05 65_[+2]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAWT MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAAATAWT width=8 seqs=12 chr1:226187673-226187753 ( 46) AAAATATT 1 chr18:3604930-3605010 ( 33) AAAATATT 1 chr6:26331742-26331822 ( 45) AAAATAAT 1 chr10:21815708-21815788 ( 28) AAAATAAT 1 chr18:3653420-3653500 ( 5) AAAATAAT 1 chr11:78036497-78036577 ( 46) ATAATATT 1 chr1:26396541-26396621 ( 63) AAAATTTT 1 chr1:26453632-26453712 ( 70) AAAATTTT 1 chr11:16760330-16760410 ( 63) ATAATAAT 1 chr19:52050544-52050624 ( 45) AACATATT 1 chr2:37789251-37789331 ( 4) AAAATACT 1 chr3:176914548-176914628 ( 66) AACATAAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAWT MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 12.1553 E= 3.7e+003 219 -1023 -1023 -1023 193 -1023 -1023 -45 193 -70 -1023 -1023 219 -1023 -1023 -1023 -1023 -1023 -1023 213 193 -1023 -1023 -45 93 -170 -1023 113 -1023 -1023 -1023 213 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAWT MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 12 E= 3.7e+003 1.000000 0.000000 0.000000 0.000000 0.833333 0.000000 0.000000 0.166667 0.833333 0.166667 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.833333 0.000000 0.000000 0.166667 0.416667 0.083333 0.000000 0.500000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAATAWT MEME-2 regular expression -------------------------------------------------------------------------------- AAAATA[TA]T -------------------------------------------------------------------------------- Time 8.79 secs. ******************************************************************************** ******************************************************************************** MOTIF YTTAAWAT MEME-3 width = 8 sites = 18 llr = 164 E-value = 3.1e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif YTTAAWAT MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::8a4a2 pos.-specific C 3::::::: probability G :2:2:::: matrix T 78a::6:8 bits 2.2 * * * 2.0 * * * 1.8 * * * 1.5 **** * Relative 1.3 **** ** Entropy 1.1 ******** (13.1 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TTTAATAT consensus C A A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YTTAAWAT MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:58958418-58958498 54 6.47e-06 GCCCAGATCT TTTAATAT TCTTAGTGAG chr10:93368449-93368529 12 1.27e-05 CCAGACAGCA TTTAAAAT GCACTTCAGC chr18:3606040-3606120 32 1.27e-05 AGATTTCATT TTTAAAAT GAAAGTGAAA chr9:132650031-132650111 21 1.27e-05 GGCAGGTTCT TTTAAAAT TAGTCATCTT chr10:21815708-21815788 11 1.27e-05 GAAGGACGAG TTTAAAAT GGAGAGTTTA chr20:45989230-45989310 50 2.04e-05 ACGTGTCTCT CTTAATAT TCCCAGGGTA chr6:28533798-28533878 29 2.04e-05 caattgctgt cttaatat catgtcttaa chr1:26453632-26453712 26 2.78e-05 tcaagctgca cttaaaat gtttacattt chr6:8065034-8065114 33 3.40e-05 attagaacaa tttaataa aagttatgtg chr6:49604184-49604264 51 5.63e-05 ATCACAAACA TGTAATAT CCTTAGCACT chr17:57882742-57882822 42 5.63e-05 CTTAAGTATG TTTGATAT TGTTAGGTGA chr9:100743058-100743138 41 5.63e-05 CCTGGCATTA TTTGATAT TTTTATTACT chr16:87812291-87812371 42 5.63e-05 cggctaattt tgtaatat tttgtacaga chr12:54412372-54412452 39 5.63e-05 TGTGTTGCAG TTTGATAT ATGACCCCGC chr1:52345167-52345247 17 7.20e-05 TGGTTAGCAA TGTAAAAT GTGACGGAAA chrX:48659503-48659583 6 7.94e-05 gcagc cttaataa tgggaactac chr1:26396541-26396621 16 8.65e-05 AAGAAGAGGC CTTAAAAA CAAAGGGCTG chr17:41277976-41278056 66 8.65e-05 GAAACTAGGC CTTAAAAA GATACGT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YTTAAWAT MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:58958418-58958498 6.5e-06 53_[+3]_19 chr10:93368449-93368529 1.3e-05 11_[+3]_61 chr18:3606040-3606120 1.3e-05 31_[+3]_41 chr9:132650031-132650111 1.3e-05 20_[+3]_52 chr10:21815708-21815788 1.3e-05 10_[+3]_62 chr20:45989230-45989310 2e-05 49_[+3]_23 chr6:28533798-28533878 2e-05 28_[+3]_44 chr1:26453632-26453712 2.8e-05 25_[+3]_47 chr6:8065034-8065114 3.4e-05 32_[+3]_40 chr6:49604184-49604264 5.6e-05 50_[+3]_22 chr17:57882742-57882822 5.6e-05 41_[+3]_31 chr9:100743058-100743138 5.6e-05 40_[+3]_32 chr16:87812291-87812371 5.6e-05 41_[+3]_31 chr12:54412372-54412452 5.6e-05 38_[+3]_34 chr1:52345167-52345247 7.2e-05 16_[+3]_56 chrX:48659503-48659583 7.9e-05 5_[+3]_67 chr1:26396541-26396621 8.6e-05 15_[+3]_57 chr17:41277976-41278056 8.6e-05 65_[+3]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YTTAAWAT MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF YTTAAWAT width=8 seqs=18 chr2:58958418-58958498 ( 54) TTTAATAT 1 chr10:93368449-93368529 ( 12) TTTAAAAT 1 chr18:3606040-3606120 ( 32) TTTAAAAT 1 chr9:132650031-132650111 ( 21) TTTAAAAT 1 chr10:21815708-21815788 ( 11) TTTAAAAT 1 chr20:45989230-45989310 ( 50) CTTAATAT 1 chr6:28533798-28533878 ( 29) CTTAATAT 1 chr1:26453632-26453712 ( 26) CTTAAAAT 1 chr6:8065034-8065114 ( 33) TTTAATAA 1 chr6:49604184-49604264 ( 51) TGTAATAT 1 chr17:57882742-57882822 ( 42) TTTGATAT 1 chr9:100743058-100743138 ( 41) TTTGATAT 1 chr16:87812291-87812371 ( 42) TGTAATAT 1 chr12:54412372-54412452 ( 39) TTTGATAT 1 chr1:52345167-52345247 ( 17) TGTAAAAT 1 chrX:48659503-48659583 ( 6) CTTAATAA 1 chr1:26396541-26396621 ( 16) CTTAAAAA 1 chr17:41277976-41278056 ( 66) CTTAAAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YTTAAWAT MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 11.3895 E= 3.1e+003 -1081 30 -1081 155 -1081 -1081 -76 187 -1081 -1081 -1081 213 193 -1081 -76 -1081 219 -1081 -1081 -1081 102 -1081 -1081 129 219 -1081 -1081 -1081 2 -1081 -1081 177 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YTTAAWAT MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 18 E= 3.1e+003 0.000000 0.333333 0.000000 0.666667 0.000000 0.000000 0.166667 0.833333 0.000000 0.000000 0.000000 1.000000 0.833333 0.000000 0.166667 0.000000 1.000000 0.000000 0.000000 0.000000 0.444444 0.000000 0.000000 0.555556 1.000000 0.000000 0.000000 0.000000 0.222222 0.000000 0.000000 0.777778 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YTTAAWAT MEME-3 regular expression -------------------------------------------------------------------------------- [TC]TTAA[TA]A[TA] -------------------------------------------------------------------------------- Time 12.54 secs. ******************************************************************************** ******************************************************************************** MOTIF CCHCCTCC MEME-4 width = 8 sites = 37 llr = 289 E-value = 4.0e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCHCCTCC MEME-4 Description -------------------------------------------------------------------------------- Simplified A ::2::::: pos.-specific C aa3783aa probability G ::1::::: matrix T ::4327:: bits 2.2 2.0 ** ** 1.8 ** ** 1.5 ** ** Relative 1.3 ** * ** Entropy 1.1 ** ***** (11.3 bits) 0.9 ** ***** 0.7 ** ***** 0.4 ** ***** 0.2 ******** 0.0 -------- Multilevel CCTCCTCC consensus CT C sequence A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCHCCTCC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:54070502-54070582 28 2.06e-05 TTCAGAGCAG CCTCCTCC ACAACATTCC chr2:160472439-160472519 56 2.06e-05 ATCTCCGTGT CCTCCTCC CCCAAACTCC chr15:69110130-69110210 41 2.06e-05 GCTCCCCCTG CCTCCTCC GCGCGGGAGG chr3:13461156-13461236 53 4.51e-05 TGCCCCGGCG CCCCCTCC CGGGTCAGGC chr2:25195235-25195315 47 4.51e-05 TGCTCCTCTT CCCCCTCC AATATTTTGT chr9:132250431-132250511 15 4.51e-05 tcacacCAAC CCCCCTCC CCCAAATCTG chr1:51443409-51443489 4 4.51e-05 CAG CCCCCTCC TGCCGCGACC chr12:125406332-12540641 37 4.51e-05 tgagctacat ccccCTCC CTTTCCTGTA chr6:105405417-105405497 26 4.51e-05 TATACACCTG CCCCCTCC CCCATTCCAC chr1:154974348-154974428 25 4.51e-05 CCTGGTGGCT CCCCCTCC CCCTCCCTTC chr16:30661584-30661664 13 4.51e-05 GCCTCCACCA CCCCCTCC TAAACTCGGA chr6:90062314-90062394 14 6.48e-05 CGGGCCGCTG CCACCTCC TCTCCACGCG chr19:953007-953087 65 6.48e-05 GACCTTCCTC CCACCTCC CAGAGCCG chr10:5854830-5854910 38 8.22e-05 GCCCGGGCGG CCTTCTCC CCTCCCCTCC chr11:32454943-32455023 63 8.22e-05 AGGGCAGAGC CCTTCTCC CGAGCCTTGG chr12:53400421-53400501 53 1.07e-04 GACACCTTCC CCTCCCCC TCACACTCTT chr3:9439858-9439938 70 1.07e-04 GGACGCTTCC CCTCCCCC AAC chr22:29664475-29664555 24 1.07e-04 ATTCCTCTCC CCTCCCCC AACCGGGCGG chr12:74931808-74931888 57 1.27e-04 AAAACGAGCG CCCTCTCC GCACTCGTTT chrX:123095123-123095203 30 1.56e-04 ACGGAGACCC CCCCCCCC CATGGGTGGC chrX:110924550-110924630 22 1.90e-04 TCGCCACCCG CCATCTCC GGCCATACTG chr19:58897920-58898000 36 1.90e-04 GGCGGTCTCC CCTCTTCC ACGGGCGAGA chr14:102177426-10217750 41 2.14e-04 GGCCGCCTGT CCACCCCC CTCACTCAAC chr10:74033101-74033181 17 2.14e-04 TCTGTGGACC CCACCCCC ATATCCCGAG chr11:118443476-11844355 8 2.14e-04 TTCCGCA CCACCCCC CAACCAGCTG chr1:26799142-26799222 31 2.80e-04 accgccgccg ccgccTCC CTGGTGCAGG chr7:26239842-26239922 61 2.80e-04 ATAAGAATTC CCGCCTCC GCGCCCCACT chr13:45915102-45915182 6 2.80e-04 CTGCG CCTTCCCC GCCCCCACCC chr1:156630613-156630693 5 2.80e-04 TGGG CCTTCCCC ACCCTATTTC chr19:54641675-54641755 64 2.80e-04 CTGGGCCGGA CCCCTTCC CTTCCTCCC chr3:5229877-5229957 59 2.80e-04 ATGGCTCACG CCTTCCCC CAGGACGAGC chr19:39340332-39340412 57 2.80e-04 gccaccgccg ccgcctcc gTGCTGGTCG chrX:11359818-11359898 41 2.97e-04 CTGGGATGAT CCACTTCC ATTAGAACAA chr6:42751626-42751706 27 3.36e-04 GGGCATTGAG CCTTTTCC TTAATTCTTC chr1:245134554-245134634 49 3.77e-04 GCCGGCCGGG CCTCTCCC AGGGGACCAC chr19:18393193-18393273 28 3.77e-04 ggtggagtga ccatcccc cgagagttag chr18:3447874-3447954 26 4.15e-04 AAGCTATAAA CCCTTTCC AATTCTCGGT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCHCCTCC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:54070502-54070582 2.1e-05 27_[+4]_45 chr2:160472439-160472519 2.1e-05 55_[+4]_17 chr15:69110130-69110210 2.1e-05 40_[+4]_32 chr3:13461156-13461236 4.5e-05 52_[+4]_20 chr2:25195235-25195315 4.5e-05 46_[+4]_26 chr9:132250431-132250511 4.5e-05 14_[+4]_58 chr1:51443409-51443489 4.5e-05 3_[+4]_69 chr12:125406332-12540641 4.5e-05 36_[+4]_36 chr6:105405417-105405497 4.5e-05 25_[+4]_47 chr1:154974348-154974428 4.5e-05 24_[+4]_48 chr16:30661584-30661664 4.5e-05 12_[+4]_60 chr6:90062314-90062394 6.5e-05 13_[+4]_59 chr19:953007-953087 6.5e-05 64_[+4]_8 chr10:5854830-5854910 8.2e-05 37_[+4]_35 chr11:32454943-32455023 8.2e-05 62_[+4]_10 chr12:53400421-53400501 0.00011 52_[+4]_20 chr3:9439858-9439938 0.00011 69_[+4]_3 chr22:29664475-29664555 0.00011 23_[+4]_49 chr12:74931808-74931888 0.00013 56_[+4]_16 chrX:123095123-123095203 0.00016 29_[+4]_43 chrX:110924550-110924630 0.00019 21_[+4]_51 chr19:58897920-58898000 0.00019 35_[+4]_37 chr14:102177426-10217750 0.00021 40_[+4]_32 chr10:74033101-74033181 0.00021 16_[+4]_56 chr11:118443476-11844355 0.00021 7_[+4]_65 chr1:26799142-26799222 0.00028 30_[+4]_42 chr7:26239842-26239922 0.00028 60_[+4]_12 chr13:45915102-45915182 0.00028 5_[+4]_67 chr1:156630613-156630693 0.00028 4_[+4]_68 chr19:54641675-54641755 0.00028 63_[+4]_9 chr3:5229877-5229957 0.00028 58_[+4]_14 chr19:39340332-39340412 0.00028 56_[+4]_16 chrX:11359818-11359898 0.0003 40_[+4]_32 chr6:42751626-42751706 0.00034 26_[+4]_46 chr1:245134554-245134634 0.00038 48_[+4]_24 chr19:18393193-18393273 0.00038 27_[+4]_45 chr18:3447874-3447954 0.00042 25_[+4]_47 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCHCCTCC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCHCCTCC width=8 seqs=37 chrX:54070502-54070582 ( 28) CCTCCTCC 1 chr2:160472439-160472519 ( 56) CCTCCTCC 1 chr15:69110130-69110210 ( 41) CCTCCTCC 1 chr3:13461156-13461236 ( 53) CCCCCTCC 1 chr2:25195235-25195315 ( 47) CCCCCTCC 1 chr9:132250431-132250511 ( 15) CCCCCTCC 1 chr1:51443409-51443489 ( 4) CCCCCTCC 1 chr12:125406332-12540641 ( 37) CCCCCTCC 1 chr6:105405417-105405497 ( 26) CCCCCTCC 1 chr1:154974348-154974428 ( 25) CCCCCTCC 1 chr16:30661584-30661664 ( 13) CCCCCTCC 1 chr6:90062314-90062394 ( 14) CCACCTCC 1 chr19:953007-953087 ( 65) CCACCTCC 1 chr10:5854830-5854910 ( 38) CCTTCTCC 1 chr11:32454943-32455023 ( 63) CCTTCTCC 1 chr12:53400421-53400501 ( 53) CCTCCCCC 1 chr3:9439858-9439938 ( 70) CCTCCCCC 1 chr22:29664475-29664555 ( 24) CCTCCCCC 1 chr12:74931808-74931888 ( 57) CCCTCTCC 1 chrX:123095123-123095203 ( 30) CCCCCCCC 1 chrX:110924550-110924630 ( 22) CCATCTCC 1 chr19:58897920-58898000 ( 36) CCTCTTCC 1 chr14:102177426-10217750 ( 41) CCACCCCC 1 chr10:74033101-74033181 ( 17) CCACCCCC 1 chr11:118443476-11844355 ( 8) CCACCCCC 1 chr1:26799142-26799222 ( 31) CCGCCTCC 1 chr7:26239842-26239922 ( 61) CCGCCTCC 1 chr13:45915102-45915182 ( 6) CCTTCCCC 1 chr1:156630613-156630693 ( 5) CCTTCCCC 1 chr19:54641675-54641755 ( 64) CCCCTTCC 1 chr3:5229877-5229957 ( 59) CCTTCCCC 1 chr19:39340332-39340412 ( 57) CCGCCTCC 1 chrX:11359818-11359898 ( 41) CCACTTCC 1 chr6:42751626-42751706 ( 27) CCTTTTCC 1 chr1:245134554-245134634 ( 49) CCTCTCCC 1 chr19:18393193-18393273 ( 28) CCATCCCC 1 chr18:3447874-3447954 ( 26) CCCTTTCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCHCCTCC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.3679 E= 4.0e+003 -1185 188 -1185 -1185 -1185 188 -1185 -1185 -2 26 -180 73 -1185 143 -1185 25 -1185 163 -1185 -49 -1185 26 -1185 157 -1185 188 -1185 -1185 -1185 188 -1185 -1185 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCHCCTCC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 37 E= 4.0e+003 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.216216 0.324324 0.081081 0.378378 0.000000 0.729730 0.000000 0.270270 0.000000 0.837838 0.000000 0.162162 0.000000 0.324324 0.000000 0.675676 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCHCCTCC MEME-4 regular expression -------------------------------------------------------------------------------- CC[TCA][CT]C[TC]CC -------------------------------------------------------------------------------- Time 16.27 secs. ******************************************************************************** ******************************************************************************** MOTIF WYWKTTTY MEME-5 width = 8 sites = 32 llr = 264 E-value = 3.4e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif WYWKTTTY MEME-5 Description -------------------------------------------------------------------------------- Simplified A 3:4::::: pos.-specific C :7:::::5 probability G :::4:::: matrix T 7366aaa5 bits 2.2 *** 2.0 *** 1.8 *** 1.5 *** Relative 1.3 * *** Entropy 1.1 ******** (11.9 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TCTTTTTC consensus ATAG T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WYWKTTTY MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:85839412-85839492 60 8.68e-06 TGCCTTCCCA TCTTTTTT CTGGTAATAG chr1:160510664-160510744 46 8.68e-06 CATCAGCTTT TCTTTTTT TCTTTGTCTG chr2:25195235-25195315 9 1.90e-05 TTCTGGAT TCTTTTTC GGTTCCATGG chr19:953007-953087 46 1.90e-05 ACCTCTGGGG TCTTTTTC TGACCTTCCT chr6:147205255-147205335 23 1.90e-05 cttatttccc tctttttc tccttttcgc chr17:46662584-46662664 43 2.73e-05 CCACCCTTCT TCATTTTT GACACCCGAG chr22:35795427-35795507 69 3.46e-05 AAAAGGGTCA TTTTTTTT CATA chr12:57915311-57915391 40 4.45e-05 CCCTTGGTAG TCATTTTC CGCTTCTCTC chr1:226187673-226187753 37 7.23e-05 CCACTTCAGC TCTGTTTT CAAAATATTT chr6:28912360-28912440 70 7.23e-05 gggcaAGGCG TCTGTTTT GCC chr18:9915210-9915290 12 7.23e-05 AGTGCGTGTG ACTTTTTT GCTTTTACGT chr1:234859331-234859411 31 7.23e-05 CTCAGGGAAT ACTTTTTT GCTCTTCGTG chr17:1620202-1620282 34 7.23e-05 CACAGGAGGC TTTTTTTC TTGGATGTCT chr1:16212518-16212598 38 1.02e-04 TGTAAATAGG TCTGTTTC CTTTCTGGAT chr10:93368449-93368529 70 1.02e-04 GTCTTGACAT TCTGTTTC TCC chr8:27695829-27695909 49 1.02e-04 GCCGCTCATT TCTGTTTC GAGGTACACC chr6:7698372-7698452 47 1.02e-04 GTTAGTCATG TTATTTTT GGTTCATGCC chr17:57915779-57915859 52 1.29e-04 GCTCTCACTC ACATTTTT AGGCAAATAA chr7:151622690-151622770 22 1.29e-04 GGGCTTGTTT TTATTTTC TCCGCTTAGT chr1:26453632-26453712 38 1.29e-04 taaaatgttt acattttt ctctaggtat chr18:3447874-3447954 7 1.45e-04 GGAAAG TTTGTTTT CAAGCTATAA chr5:43008403-43008483 69 1.45e-04 TCTGGGTTGt tttgtttt tgag chr10:24858826-24858906 38 1.66e-04 GTTGATAAAC TCAGTTTC ATTCAAACCT chr4:119756637-119756717 33 1.66e-04 TTTGGCCAGA TCAGTTTC ACTATTCGGA chr3:176914548-176914628 52 1.66e-04 GCCGAGGTGC ACATTTTC GGGGACAACA chr20:45987538-45987618 2 1.96e-04 T ACTGTTTT AGGCTGCTGA chr6:27805524-27805604 39 2.24e-04 TAAAAGCCGT TTAGTTTT GCTTCATCTC chr7:130645452-130645532 66 2.24e-04 TGTAACAGTC ACTGTTTC ATAAATC chrX:65235541-65235621 46 2.52e-04 AGGGGATAGG ATATTTTC TATCCAATCA chr6:26200220-26200300 28 2.52e-04 AATTACCTGC ATATTTTC CGTGTTTACC chr3:5471390-5471470 17 2.52e-04 ggagtcagag atattttc taatagcact chr5:180633890-180633970 72 2.60e-04 ACATTCAATT ATTGTTTT C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WYWKTTTY MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:85839412-85839492 8.7e-06 59_[+5]_13 chr1:160510664-160510744 8.7e-06 45_[+5]_27 chr2:25195235-25195315 1.9e-05 8_[+5]_64 chr19:953007-953087 1.9e-05 45_[+5]_27 chr6:147205255-147205335 1.9e-05 22_[+5]_50 chr17:46662584-46662664 2.7e-05 42_[+5]_30 chr22:35795427-35795507 3.5e-05 68_[+5]_4 chr12:57915311-57915391 4.5e-05 39_[+5]_33 chr1:226187673-226187753 7.2e-05 36_[+5]_36 chr6:28912360-28912440 7.2e-05 69_[+5]_3 chr18:9915210-9915290 7.2e-05 11_[+5]_61 chr1:234859331-234859411 7.2e-05 30_[+5]_42 chr17:1620202-1620282 7.2e-05 33_[+5]_39 chr1:16212518-16212598 0.0001 37_[+5]_35 chr10:93368449-93368529 0.0001 69_[+5]_3 chr8:27695829-27695909 0.0001 48_[+5]_24 chr6:7698372-7698452 0.0001 46_[+5]_26 chr17:57915779-57915859 0.00013 51_[+5]_21 chr7:151622690-151622770 0.00013 21_[+5]_51 chr1:26453632-26453712 0.00013 37_[+5]_35 chr18:3447874-3447954 0.00014 6_[+5]_66 chr5:43008403-43008483 0.00014 68_[+5]_4 chr10:24858826-24858906 0.00017 37_[+5]_35 chr4:119756637-119756717 0.00017 32_[+5]_40 chr3:176914548-176914628 0.00017 51_[+5]_21 chr20:45987538-45987618 0.0002 1_[+5]_71 chr6:27805524-27805604 0.00022 38_[+5]_34 chr7:130645452-130645532 0.00022 65_[+5]_7 chrX:65235541-65235621 0.00025 45_[+5]_27 chr6:26200220-26200300 0.00025 27_[+5]_45 chr3:5471390-5471470 0.00025 16_[+5]_56 chr5:180633890-180633970 0.00026 71_[+5]_1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WYWKTTTY MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF WYWKTTTY width=8 seqs=32 chr2:85839412-85839492 ( 60) TCTTTTTT 1 chr1:160510664-160510744 ( 46) TCTTTTTT 1 chr2:25195235-25195315 ( 9) TCTTTTTC 1 chr19:953007-953087 ( 46) TCTTTTTC 1 chr6:147205255-147205335 ( 23) TCTTTTTC 1 chr17:46662584-46662664 ( 43) TCATTTTT 1 chr22:35795427-35795507 ( 69) TTTTTTTT 1 chr12:57915311-57915391 ( 40) TCATTTTC 1 chr1:226187673-226187753 ( 37) TCTGTTTT 1 chr6:28912360-28912440 ( 70) TCTGTTTT 1 chr18:9915210-9915290 ( 12) ACTTTTTT 1 chr1:234859331-234859411 ( 31) ACTTTTTT 1 chr17:1620202-1620282 ( 34) TTTTTTTC 1 chr1:16212518-16212598 ( 38) TCTGTTTC 1 chr10:93368449-93368529 ( 70) TCTGTTTC 1 chr8:27695829-27695909 ( 49) TCTGTTTC 1 chr6:7698372-7698452 ( 47) TTATTTTT 1 chr17:57915779-57915859 ( 52) ACATTTTT 1 chr7:151622690-151622770 ( 22) TTATTTTC 1 chr1:26453632-26453712 ( 38) ACATTTTT 1 chr18:3447874-3447954 ( 7) TTTGTTTT 1 chr5:43008403-43008483 ( 69) TTTGTTTT 1 chr10:24858826-24858906 ( 38) TCAGTTTC 1 chr4:119756637-119756717 ( 33) TCAGTTTC 1 chr3:176914548-176914628 ( 52) ACATTTTC 1 chr20:45987538-45987618 ( 2) ACTGTTTT 1 chr6:27805524-27805604 ( 39) TTAGTTTT 1 chr7:130645452-130645532 ( 66) ACTGTTTC 1 chrX:65235541-65235621 ( 46) ATATTTTC 1 chr6:26200220-26200300 ( 28) ATATTTTC 1 chr3:5471390-5471470 ( 17) ATATTTTC 1 chr5:180633890-180633970 ( 72) ATTGTTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WYWKTTTY MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 18250 bayes= 10.4765 E= 3.4e+002 65 -1164 -1164 153 -1164 127 -1164 59 89 -1164 -1164 138 -1164 -1164 53 138 -1164 -1164 -1164 213 -1164 -1164 -1164 213 -1164 -1164 -1164 213 -1164 88 -1164 113 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WYWKTTTY MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 32 E= 3.4e+002 0.343750 0.000000 0.000000 0.656250 0.000000 0.656250 0.000000 0.343750 0.406250 0.000000 0.000000 0.593750 0.000000 0.000000 0.406250 0.593750 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.500000 0.000000 0.500000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WYWKTTTY MEME-5 regular expression -------------------------------------------------------------------------------- [TA][CT][TA][TG]TTT[CT] -------------------------------------------------------------------------------- Time 19.97 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:91925278-91925358 9.12e-01 80 chr18:3653420-3653500 6.20e-04 4_[+2(1.17e-05)]_68 chr6:168257265-168257345 3.58e-02 80 chr3:176914548-176914628 3.54e-03 65_[+2(5.77e-05)]_7 chr1:228270832-228270912 9.59e-01 80 chr15:69110130-69110210 2.04e-01 40_[+4(2.06e-05)]_32 chr7:20260060-20260140 3.09e-01 80 chr14:100842215-10084229 4.43e-01 80 chrX:123094868-123094948 2.50e-01 80 chr16:70322870-70322950 1.61e-03 26_[+1(6.53e-05)]_46 chr1:26453632-26453712 7.21e-07 2_[+1(1.94e-05)]_15_[+3(2.78e-05)]_\ 32_[+1(1.94e-05)]_7 chr1:160231698-160231778 9.96e-01 80 chr6:135643939-135644019 2.13e-01 80 chr18:3602833-3602913 5.58e-01 80 chr7:106208904-106208984 3.54e-02 5_[+2(8.57e-05)]_67 chr11:61735857-61735937 5.88e-01 80 chr19:18393193-18393273 5.99e-01 80 chr16:30661584-30661664 8.51e-02 12_[+4(4.51e-05)]_60 chr6:12011213-12011293 1.00e+00 80 chr9:86594851-86594931 9.93e-01 80 chr5:39202409-39202489 9.73e-01 80 chr10:21815708-21815788 9.33e-06 10_[+3(1.27e-05)]_9_[+2(1.17e-05)]_\ 16_[+1(2.65e-05)]_21 chr21:38445069-38445149 9.80e-01 80 chr18:3596523-3596603 7.05e-03 30_[+5(3.46e-05)]_[+5(7.23e-05)]_34 chr3:5471390-5471470 8.65e-02 80 chr9:132650031-132650111 1.08e-02 20_[+3(1.27e-05)]_52 chr22:21997053-21997133 8.61e-01 80 chr1:154193735-154193815 9.93e-01 80 chrX:123095123-123095203 2.32e-01 80 chr12:54412372-54412452 2.93e-02 38_[+3(5.63e-05)]_34 chr21:36577451-36577531 3.24e-03 35_[+3(3.40e-05)]_37 chr18:3606040-3606120 2.93e-05 31_[+3(1.27e-05)]_41 chr4:10182210-10182290 1.20e-01 80 chr9:131037693-131037773 9.25e-01 80 chr2:37789251-37789331 3.51e-02 3_[+2(5.77e-05)]_69 chr17:1620202-1620282 1.54e-01 33_[+5(7.23e-05)]_39 chr6:26200220-26200300 1.81e-01 80 chr11:122933724-12293380 2.92e-01 80 chr16:47496624-47496704 1.33e-02 18_[+5(3.46e-05)]_[+5(3.46e-05)]_46 chr6:73268981-73269061 1.69e-02 50_[+1(6.53e-05)]_22 chr18:3596135-3596215 5.36e-05 14_[+2(8.57e-05)]_5_[+5(8.68e-06)]_\ 45 chr19:41770628-41770708 7.05e-01 80 chrX:48659503-48659583 1.03e-02 5_[+3(7.94e-05)]_67 chr1:27113997-27114077 3.17e-01 80 chr1:24970220-24970300 4.75e-01 80 chr16:87812291-87812371 7.90e-03 41_[+3(5.63e-05)]_31 chr22:38901999-38902079 8.11e-01 80 chr6:26021023-26021103 9.42e-01 80 chr7:130645452-130645532 1.73e-02 80 chr19:52050544-52050624 1.53e-04 30_[+1(1.26e-05)]_6_[+2(4.35e-05)]_\ 28 chr18:9876938-9877018 3.15e-03 45_[+1(4.97e-05)]_27 chr11:118443476-11844355 3.33e-01 80 chr16:28834910-28834990 9.95e-01 80 chr18:3603917-3603997 5.03e-02 35_[+1(4.06e-05)]_37 chr11:61559777-61559857 1.01e-01 80 chr2:160472439-160472519 1.37e-01 22_[+4(6.48e-05)]_25_[+4(2.06e-05)]_\ 17 chr5:102455374-102455454 3.52e-01 80 chr1:206845913-206845993 2.84e-01 80 chr1:160510664-160510744 5.10e-02 45_[+5(8.68e-06)]_27 chr4:10183755-10183835 8.75e-01 80 chr9:110046106-110046186 9.70e-01 80 chr20:45987538-45987618 3.63e-01 80 chr3:196066128-196066208 1.73e-01 80 chr22:35795427-35795507 1.21e-02 65_[+5(2.73e-05)]_7 chr8:30602222-30602302 9.85e-02 80 chr19:39340332-39340412 6.48e-01 80 chr6:7698372-7698452 5.58e-03 80 chr3:31573262-31573342 1.91e-02 80 chr22:21996715-21996795 9.13e-01 80 chr17:41277976-41278056 7.83e-03 65_[+3(8.65e-05)]_7 chr1:234859331-234859411 5.38e-02 30_[+5(7.23e-05)]_42 chr7:151622690-151622770 1.28e-01 80 chr6:28533798-28533878 8.81e-03 28_[+3(2.04e-05)]_44 chr10:74033101-74033181 2.42e-01 80 chr17:46703116-46703196 1.02e-01 80 chr8:38240283-38240363 7.23e-01 80 chr19:52773159-52773239 6.40e-01 80 chr6:8102245-8102325 7.31e-01 80 chr2:136499752-136499832 4.10e-01 80 chr6:147205255-147205335 4.35e-03 22_[+5(1.90e-05)]_50 chr6:32938151-32938231 7.52e-01 80 chr22:29664475-29664555 3.78e-01 80 chr9:100743058-100743138 7.91e-03 40_[+3(5.63e-05)]_32 chr3:5229877-5229957 3.48e-01 80 chr6:24722154-24722234 8.39e-01 80 chr17:49198883-49198963 2.23e-04 20_[+1(5.51e-06)]_52 chr21:43299796-43299876 9.96e-01 80 chr20:34329799-34329879 2.58e-01 80 chr19:52050787-52050867 1.45e-01 80 chr19:54641675-54641755 6.06e-01 80 chr22:19706262-19706342 1.00e+00 80 chr6:42751626-42751706 6.70e-02 80 chr1:154974348-154974428 2.78e-01 24_[+4(4.51e-05)]_48 chr6:155055009-155055089 8.38e-01 80 chr11:122933509-12293358 9.98e-01 80 chr1:24018681-24018761 8.49e-01 80 chr11:59313578-59313658 7.94e-03 80 chr12:57915311-57915391 3.46e-02 39_[+5(4.45e-05)]_33 chr3:9833900-9833980 8.90e-01 80 chr19:58897920-58898000 3.54e-01 80 chr9:132245790-132245870 8.35e-01 80 chr7:16309062-16309142 1.82e-01 80 chr22:20105574-20105654 9.99e-01 80 chr10:93367962-93368042 1.99e-01 80 chr12:57848623-57848703 5.52e-03 23_[+1(2.65e-05)]_49 chr5:43008403-43008483 4.19e-02 80 chr12:74931808-74931888 2.17e-02 80 chr2:174829859-174829939 8.28e-01 80 chr1:113161728-113161808 9.92e-01 80 chr18:3604930-3605010 2.16e-03 32_[+2(5.97e-06)]_40 chr17:57882742-57882822 2.08e-02 41_[+3(5.63e-05)]_31 chr1:38412382-38412462 7.43e-01 80 chr2:64068460-64068540 9.33e-01 80 chr3:9439858-9439938 3.19e-02 80 chr6:42751423-42751503 2.46e-01 80 chr6:28304049-28304129 9.13e-01 80 chr6:32937324-32937404 1.00e+00 80 chr5:17401006-17401086 6.23e-03 80 chr1:160509702-160509782 1.94e-01 80 chr6:27862796-27862876 4.83e-01 80 chr15:49447592-49447672 9.70e-01 80 chr3:47204838-47204918 1.00e+00 80 chr17:38804281-38804361 8.85e-01 80 chr1:31242473-31242553 2.29e-02 80 chr6:30684802-30684882 6.96e-01 80 chrX:11359818-11359898 1.68e-03 80 chr4:119756637-119756717 1.18e-01 80 chr12:93767802-93767882 2.83e-03 58_[+1(5.51e-06)]_14 chr1:245027477-245027557 9.80e-01 80 chr6:105405417-105405497 1.87e-03 25_[+4(4.51e-05)]_47 chr1:26396541-26396621 1.36e-04 1_[+1(8.60e-05)]_6_[+3(8.65e-05)]_\ 39_[+2(2.41e-05)]_10 chr5:179126399-179126479 5.96e-01 80 chr1:245134554-245134634 2.97e-01 80 chr9:132647549-132647629 4.36e-01 80 chr1:52345167-52345247 2.57e-03 16_[+3(7.20e-05)]_8_[+1(6.53e-05)]_\ 40 chr6:8065034-8065114 1.09e-03 32_[+3(3.40e-05)]_40 chr12:53773065-53773145 2.56e-01 80 chr3:169482378-169482458 8.25e-01 80 chr6:3355607-3355687 6.42e-03 64_[+1(3.18e-05)]_8 chr17:80056992-80057072 9.99e-01 80 chr2:178130094-178130174 1.52e-01 80 chr6:13575009-13575089 5.22e-01 80 chr1:156630613-156630693 9.58e-02 80 chr12:123869068-12386914 5.83e-01 80 chr10:74081270-74081350 8.52e-01 80 chr11:63974727-63974807 9.97e-01 80 chr18:9915210-9915290 1.54e-01 11_[+5(7.23e-05)]_61 chr17:57915779-57915859 6.97e-02 80 chr6:49604184-49604264 3.88e-02 50_[+3(5.63e-05)]_22 chr10:32635786-32635866 7.18e-01 80 chr8:27695829-27695909 5.34e-02 80 chr6:26205375-26205455 2.08e-01 80 chr10:93368449-93368529 4.23e-04 11_[+3(1.27e-05)]_61 chr22:21213384-21213464 5.07e-01 80 chr4:775297-775377 4.52e-01 80 chr12:53400620-53400700 4.67e-01 80 chr19:51161023-51161103 5.97e-01 80 chr2:58958418-58958498 7.76e-04 53_[+3(6.47e-06)]_19 chr11:32454943-32455023 5.65e-02 62_[+4(8.22e-05)]_10 chr1:184943183-184943263 9.66e-01 80 chr13:45915102-45915182 9.87e-02 80 chr10:94516848-94516928 5.66e-01 80 chr7:139025785-139025865 1.56e-01 80 chr12:125406332-12540641 3.87e-02 36_[+4(4.51e-05)]_36 chr17:46662584-46662664 1.86e-02 42_[+5(2.73e-05)]_30 chr14:102177426-10217750 1.54e-01 80 chr6:28912360-28912440 6.38e-02 69_[+5(7.23e-05)]_3 chr10:17243210-17243290 7.17e-01 80 chr12:113860377-11386045 9.67e-01 80 chr6:111805536-111805616 4.15e-02 80 chr21:34914614-34914694 3.68e-01 80 chr19:44259401-44259481 7.71e-01 80 chr16:22207024-22207104 9.77e-01 80 chr19:29095956-29096036 8.25e-01 80 chr20:1306182-1306262 7.11e-01 80 chr2:19986510-19986590 4.07e-01 80 chr6:27805524-27805604 4.16e-03 80 chr1:113162065-113162145 5.27e-01 80 chr19:953007-953087 4.82e-03 45_[+5(1.90e-05)]_11_[+4(6.48e-05)]_\ 8 chr22:20105776-20105856 9.94e-01 80 chr3:19987916-19987996 7.09e-03 23_[+1(4.97e-05)]_49 chr1:16212518-16212598 2.01e-02 80 chr6:43884431-43884511 9.18e-03 80 chr1:51443409-51443489 3.02e-01 3_[+4(4.51e-05)]_69 chr6:26331742-26331822 5.33e-03 44_[+2(1.17e-05)]_28 chr19:45682517-45682597 9.07e-01 80 chr18:3625116-3625196 6.28e-01 80 chr15:79165504-79165584 7.94e-01 80 chr9:132250431-132250511 6.92e-03 14_[+4(4.51e-05)]_50_[+1(4.06e-05)] chrX:110924550-110924630 2.39e-01 80 chr5:68463146-68463226 9.79e-01 80 chr11:78036497-78036577 1.23e-02 45_[+2(2.41e-05)]_27 chr1:226187673-226187753 1.31e-04 36_[+5(7.23e-05)]_1_[+2(5.97e-06)]_\ 27 chr4:40240189-40240269 1.41e-02 62_[+1(4.06e-05)]_10 chr1:234746256-234746336 5.82e-01 80 chr10:24858826-24858906 1.26e-01 80 chr5:180633890-180633970 1.62e-01 80 chr19:8455362-8455442 9.95e-01 80 chr6:150489317-150489397 6.79e-03 53_[+1(7.21e-05)]_19 chr1:193026930-193027010 1.37e-03 37_[+2(8.57e-05)]_35 chr17:49338057-49338137 8.59e-01 80 chr11:16760330-16760410 6.65e-03 62_[+2(3.61e-05)]_10 chrX:153237091-153237171 9.20e-01 80 chr12:56694656-56694736 1.20e-01 80 chr7:26239842-26239922 1.63e-03 49_[+1(8.60e-05)]_23 chr12:57623744-57623824 8.20e-01 80 chr2:20102078-20102158 5.86e-01 80 chr11:747668-747748 9.61e-01 80 chr4:48833493-48833573 9.73e-01 80 chr11:65186829-65186909 4.10e-01 80 chr11:118662050-11866213 2.73e-01 80 chr12:54719076-54719156 4.51e-01 80 chr16:69165705-69165785 2.67e-01 80 chr17:33308027-33308107 9.63e-01 80 chr5:43556578-43556658 7.92e-01 80 chr2:25195235-25195315 2.51e-04 8_[+5(1.90e-05)]_30_[+4(4.51e-05)]_\ 26 chr1:211432041-211432121 9.44e-02 80 chr20:45989230-45989310 7.59e-05 22_[+1(5.51e-06)]_19_[+3(2.04e-05)]_\ 23 chr11:59327818-59327898 6.40e-01 80 chr1:225965775-225965855 2.57e-01 80 chr11:65187028-65187108 9.20e-01 80 chr10:5854830-5854910 2.70e-01 37_[+4(8.22e-05)]_35 chr11:118662294-11866237 9.30e-01 80 chr1:203595329-203595409 5.65e-01 80 chr2:85839412-85839492 1.34e-03 59_[+5(8.68e-06)]_13 chr7:104654208-104654288 8.89e-01 80 chr1:249120748-249120828 3.80e-01 80 chr3:13461156-13461236 2.27e-01 52_[+4(4.51e-05)]_20 chr17:80057245-80057325 9.16e-01 80 chr1:62901573-62901653 7.47e-01 80 chr10:6516152-6516232 9.82e-01 80 chr22:21271891-21271971 9.97e-01 80 chr22:19706462-19706542 9.09e-01 80 chr12:53400421-53400501 6.57e-02 80 chr10:73473142-73473222 8.79e-01 80 chr6:90062314-90062394 3.43e-01 13_[+4(6.48e-05)]_59 chrX:54070502-54070582 6.63e-02 27_[+4(2.06e-05)]_45 chr1:227127012-227127092 6.38e-01 80 chr19:56166601-56166681 9.53e-01 80 chr16:30621352-30621432 9.89e-01 80 chr22:41487830-41487910 8.88e-01 80 chr1:174968273-174968353 9.50e-02 80 chr18:3447874-3447954 3.57e-02 80 chr17:30771686-30771766 1.00e+00 80 chr12:123850062-12385014 6.05e-01 80 chr1:26799142-26799222 5.00e-01 80 chr19:47615973-47616053 8.72e-01 80 chrX:65235541-65235621 1.05e-01 80 chr1:67519692-67519772 9.99e-01 80 chr15:63795919-63795999 3.71e-01 80 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n05.farnam.hpc.yale.internal ********************************************************************************