******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/TARDBP.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr12:6717104-6717124 1.0000 20 chr2:237484237-237484257 1.0000 20 chr11:1937232-1937252 1.0000 20 chr7:143083157-143083177 1.0000 20 chrX:1572519-1572539 1.0000 20 chr10:3153314-3153334 1.0000 20 chr11:1914960-1914980 1.0000 20 chr19:7705060-7705080 1.0000 20 chr16:57064444-57064464 1.0000 20 chr7:6741929-6741949 1.0000 20 chr11:111229249-11122926 1.0000 20 chr19:4815315-4815335 1.0000 20 chr2:11244402-11244422 1.0000 20 chr8:11417903-11417923 1.0000 20 chr17:38708388-38708408 1.0000 20 chr7:1043508-1043528 1.0000 20 chr17:72247416-72247436 1.0000 20 chr9:114790698-114790718 1.0000 20 chr3:127406265-127406285 1.0000 20 chr12:6717329-6717349 1.0000 20 chr2:96810040-96810060 1.0000 20 chr6:167344019-167344039 1.0000 20 chr19:38086124-38086144 1.0000 20 chr10:3142200-3142220 1.0000 20 chr13:28713610-28713630 1.0000 20 chr7:140624881-140624901 1.0000 20 chr6:11319764-11319784 1.0000 20 chr3:16549186-16549206 1.0000 20 chr21:45394449-45394469 1.0000 20 chr12:56366865-56366885 1.0000 20 chr21:46324458-46324478 1.0000 20 chr2:16837529-16837549 1.0000 20 chr8:131297137-131297157 1.0000 20 chr12:58138391-58138411 1.0000 20 chr19:18061380-18061400 1.0000 20 chr1:209943909-209943929 1.0000 20 chr12:6722352-6722372 1.0000 20 chr14:73714317-73714337 1.0000 20 chr19:10341232-10341252 1.0000 20 chr1:46806743-46806763 1.0000 20 chr17:8732708-8732728 1.0000 20 chrX:9983151-9983171 1.0000 20 chr5:17225148-17225168 1.0000 20 chr4:57303388-57303408 1.0000 20 chr19:3360760-3360780 1.0000 20 chr6:37537385-37537405 1.0000 20 chr21:45668442-45668462 1.0000 20 chr11:75063047-75063067 1.0000 20 chr2:43446441-43446461 1.0000 20 chr2:123617026-123617046 1.0000 20 chr10:11325977-11325997 1.0000 20 chr17:72510203-72510223 1.0000 20 chr15:74708662-74708682 1.0000 20 chr1:228674438-228674458 1.0000 20 chr2:55276275-55276295 1.0000 20 chr9:123964404-123964424 1.0000 20 chr7:2354718-2354738 1.0000 20 chr17:5130608-5130628 1.0000 20 chr17:76130330-76130350 1.0000 20 chr3:9932715-9932735 1.0000 20 chr12:121533775-12153379 1.0000 20 chr10:80827476-80827496 1.0000 20 chr19:56159832-56159852 1.0000 20 chr7:102920884-102920904 1.0000 20 chr4:178230800-178230820 1.0000 20 chr1:224180332-224180352 1.0000 20 chr1:236313478-236313498 1.0000 20 chr3:11684395-11684415 1.0000 20 chr15:38856440-38856460 1.0000 20 chr7:65958522-65958542 1.0000 20 chr18:77723322-77723342 1.0000 20 chr14:36278613-36278633 1.0000 20 chr19:6532533-6532553 1.0000 20 chr18:12990294-12990314 1.0000 20 chr5:95297773-95297793 1.0000 20 chr19:50862228-50862248 1.0000 20 chr5:107300591-107300611 1.0000 20 chr18:74830732-74830752 1.0000 20 chr13:28605819-28605839 1.0000 20 chr6:34664819-34664839 1.0000 20 chr2:243028653-243028673 1.0000 20 chr6:40219465-40219485 1.0000 20 chr6:7202445-7202465 1.0000 20 chr5:464270-464290 1.0000 20 chr17:2303491-2303511 1.0000 20 chr15:90727588-90727608 1.0000 20 chr1:151170894-151170914 1.0000 20 chr22:44550771-44550791 1.0000 20 chr7:2354508-2354528 1.0000 20 chr11:65153903-65153923 1.0000 20 chr21:45632066-45632086 1.0000 20 chr2:28114133-28114153 1.0000 20 chr12:121107479-12110749 1.0000 20 chr8:145682235-145682255 1.0000 20 chr1:243265060-243265080 1.0000 20 chr19:50979530-50979550 1.0000 20 chr18:11078053-11078073 1.0000 20 chr16:81831386-81831406 1.0000 20 chr3:53197295-53197315 1.0000 20 chr6:36648367-36648387 1.0000 20 chr1:2187510-2187530 1.0000 20 chr1:1136990-1137010 1.0000 20 chr3:58188871-58188891 1.0000 20 chr8:95003861-95003881 1.0000 20 chr1:207097416-207097436 1.0000 20 chr1:181478129-181478149 1.0000 20 chr6:13454944-13454964 1.0000 20 chr11:47379776-47379796 1.0000 20 chr19:12896101-12896121 1.0000 20 chr14:106151474-10615149 1.0000 20 chr22:31892103-31892123 1.0000 20 chr14:106155294-10615531 1.0000 20 chr10:106088821-10608884 1.0000 20 chr5:426682-426702 1.0000 20 chr12:54144892-54144912 1.0000 20 chr15:74907242-74907262 1.0000 20 chr17:77770792-77770812 1.0000 20 chr8:354898-354918 1.0000 20 chr6:56911288-56911308 1.0000 20 chr8:142414244-142414264 1.0000 20 chr2:74781563-74781583 1.0000 20 chr12:6723186-6723206 1.0000 20 chr1:156698674-156698694 1.0000 20 chr19:2841158-2841178 1.0000 20 chr13:74707963-74707983 1.0000 20 chr1:207097621-207097641 1.0000 20 chr11:77185463-77185483 1.0000 20 chr1:27951873-27951893 1.0000 20 chr1:936293-936313 1.0000 20 chr8:38627459-38627479 1.0000 20 chr7:148844307-148844327 1.0000 20 chr16:29679329-29679349 1.0000 20 chr2:43453107-43453127 1.0000 20 chr3:186743194-186743214 1.0000 20 chr3:165557596-165557616 1.0000 20 chr1:154580222-154580242 1.0000 20 chr5:139032361-139032381 1.0000 20 chr18:77793329-77793349 1.0000 20 chr1:100503514-100503534 1.0000 20 chr17:74511817-74511837 1.0000 20 chr21:38446201-38446221 1.0000 20 chr14:69260850-69260870 1.0000 20 chr8:41347812-41347832 1.0000 20 chr17:27055642-27055662 1.0000 20 chrX:1325033-1325053 1.0000 20 chr16:88851990-88852010 1.0000 20 chr11:65196969-65196989 1.0000 20 chr16:21946484-21946504 1.0000 20 chr19:36705057-36705077 1.0000 20 chr4:186317250-186317270 1.0000 20 chr7:154997779-154997799 1.0000 20 chr19:10381186-10381206 1.0000 20 chr15:84588296-84588316 1.0000 20 chr19:50490580-50490600 1.0000 20 chr4:8174012-8174032 1.0000 20 chr1:85425191-85425211 1.0000 20 chr8:129005504-129005524 1.0000 20 chr16:4466866-4466886 1.0000 20 chr13:33776917-33776937 1.0000 20 chr5:107007971-107007991 1.0000 20 chr9:139513120-139513140 1.0000 20 chr5:150466186-150466206 1.0000 20 chr9:100174157-100174177 1.0000 20 chr17:38697608-38697628 1.0000 20 chr10:45464497-45464517 1.0000 20 chr7:66310008-66310028 1.0000 20 chr17:6918149-6918169 1.0000 20 chr6:33176153-33176173 1.0000 20 chr2:9614460-9614480 1.0000 20 chr1:201405041-201405061 1.0000 20 chr22:37704636-37704656 1.0000 20 chr4:87857639-87857659 1.0000 20 chr16:11171887-11171907 1.0000 20 chr10:14646790-14646810 1.0000 20 chr22:50969556-50969576 1.0000 20 chr5:173700512-173700532 1.0000 20 chrX:1644989-1645009 1.0000 20 chr3:47143071-47143091 1.0000 20 chr19:45909223-45909243 1.0000 20 chr7:76009525-76009545 1.0000 20 chr19:2945288-2945308 1.0000 20 chr6:31939758-31939778 1.0000 20 chr12:46777609-46777629 1.0000 20 chr1:32479135-32479155 1.0000 20 chr14:23388123-23388143 1.0000 20 chr17:42786069-42786089 1.0000 20 chr21:43430367-43430387 1.0000 20 chr5:130970803-130970823 1.0000 20 chr4:79535274-79535294 1.0000 20 chr7:5534553-5534573 1.0000 20 chr19:7153183-7153203 1.0000 20 chr10:135162794-13516281 1.0000 20 chr19:42787562-42787582 1.0000 20 chr20:37626347-37626367 1.0000 20 chr3:5025565-5025585 1.0000 20 chr1:12261851-12261871 1.0000 20 chrX:1643488-1643508 1.0000 20 chr11:107550101-10755012 1.0000 20 chr19:4769683-4769703 1.0000 20 chrX:9979636-9979656 1.0000 20 chr19:5322334-5322354 1.0000 20 chr2:37194113-37194133 1.0000 20 chr16:88878538-88878558 1.0000 20 chr7:150329096-150329116 1.0000 20 chr19:10514907-10514927 1.0000 20 chr21:45378525-45378545 1.0000 20 chr5:78810426-78810446 1.0000 20 chr6:34641680-34641700 1.0000 20 chrX:47493383-47493403 1.0000 20 chr6:53213810-53213830 1.0000 20 chr16:84982799-84982819 1.0000 20 chr19:10542634-10542654 1.0000 20 chr3:183262537-183262557 1.0000 20 chr14:103571586-10357160 1.0000 20 chr8:28259055-28259075 1.0000 20 chr16:27460839-27460859 1.0000 20 chr6:86352874-86352894 1.0000 20 chr6:44228568-44228588 1.0000 20 chr10:75385940-75385960 1.0000 20 chr16:19079330-19079350 1.0000 20 chr4:146860083-146860103 1.0000 20 chr1:169680916-169680936 1.0000 20 chr9:37145018-37145038 1.0000 20 chr6:140864211-140864231 1.0000 20 chr6:45799331-45799351 1.0000 20 chr4:154409286-154409306 1.0000 20 chr19:1668378-1668398 1.0000 20 chr17:42264285-42264305 1.0000 20 chr13:70140407-70140427 1.0000 20 chr16:68504439-68504459 1.0000 20 chr11:537277-537297 1.0000 20 chr15:60771243-60771263 1.0000 20 chr3:13415603-13415623 1.0000 20 chr2:28974377-28974397 1.0000 20 chr2:68694763-68694783 1.0000 20 chr11:1883122-1883142 1.0000 20 chr8:103567742-103567762 1.0000 20 chr14:102780792-10278081 1.0000 20 chr2:127434935-127434955 1.0000 20 chr3:194871560-194871580 1.0000 20 chr11:93245415-93245435 1.0000 20 chr5:137673223-137673243 1.0000 20 chr11:64099283-64099303 1.0000 20 chr12:14518351-14518371 1.0000 20 chr2:219745048-219745068 1.0000 20 chrX:84748030-84748050 1.0000 20 chr17:72510402-72510422 1.0000 20 chr2:100107109-100107129 1.0000 20 chr2:234073943-234073963 1.0000 20 chr21:45379239-45379259 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_TARDBP/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/TARDBP.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.215 C 0.278 G 0.277 T 0.23 Background letter frequencies (from file dataset with add-one prior applied): A 0.215 C 0.278 G 0.277 T 0.23 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF ACACACAC MEME-1 width = 8 sites = 48 llr = 388 E-value = 2.1e-045 ******************************************************************************** -------------------------------------------------------------------------------- Motif ACACACAC MEME-1 Description -------------------------------------------------------------------------------- Simplified A 8:9:8:a1 pos.-specific C 19182a:8 probability G :::::::: matrix T 1::21::: bits 2.2 2.0 * 1.8 * ** 1.6 * ** Relative 1.3 **** ** Entropy 1.1 ******** (11.7 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel ACACACAC consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr4:146860083-146860103 8 1.28e-05 ctctGTC ACACACAC ACACA chr6:44228568-44228588 10 1.28e-05 cacacacac acacacac aca chr3:183262537-183262557 5 1.28e-05 acac acacacac acacacac chr6:34641680-34641700 8 1.28e-05 tacacac acacacac acaca chrX:9979636-9979656 12 1.28e-05 acacacacgc acacacac a chr1:85425191-85425211 11 1.28e-05 CTAGGAAACT acacacac ag chr19:36705057-36705077 7 1.28e-05 acaaac acacacac CAAGGG chr13:74707963-74707983 13 1.28e-05 gcgcgcacac acacacac chr19:12896101-12896121 11 1.28e-05 cctctttttc acacacac ac chr18:11078053-11078073 6 1.28e-05 cacac acacacac cacacac chr18:74830732-74830752 4 1.28e-05 gcc acacacac tccacaccc chr17:5130608-5130628 4 1.28e-05 cac acacacac tcttacact chr15:74708662-74708682 8 1.28e-05 cacacac acacacac acaca chr12:56366865-56366885 6 1.28e-05 acacc acacacac atcatat chr3:16549186-16549206 4 1.28e-05 taa acacacac atacacaca chr6:11319764-11319784 11 1.28e-05 taacatgcgg acacacac ta chr7:6741929-6741949 10 1.28e-05 cacaaacac acacacac aca chr5:150466186-150466206 12 2.33e-05 acagaaagac acatacac g chr10:106088821-10608884 2 2.33e-05 c acatacac acatgcacgc chr11:47379776-47379796 5 2.33e-05 gctt acatacac attcacac chr17:8732708-8732728 11 2.33e-05 acgcatgcac acatacac ac chr7:150329096-150329116 1 3.32e-05 . acacacaa cactcacata chr10:135162794-13516281 12 3.32e-05 cacatccacc acacacaa a chr19:7153183-7153203 6 3.32e-05 cacaa acacacaa ccacaca chr11:111229249-11122926 10 3.32e-05 cacgccatc acacacaa aca chrX:1644989-1645009 6 4.97e-05 TCAAT ACACCCAC TATTCAG chr8:129005504-129005524 9 4.97e-05 ACACCGTC ACACCCAC AGAC chr3:194871560-194871580 13 6.33e-05 gcacactctc tcacacac chr15:60771243-60771263 1 7.98e-05 . CCACACAC GCTCCACCCC chr12:14518351-14518371 12 1.14e-04 TCCACTCAAA AAACACAC C chr6:167344019-167344039 1 1.14e-04 . acacacat gcccacatgc chr3:127406265-127406285 3 1.49e-04 at ACCCACAC TCATCCATTC chr1:154580222-154580242 1 1.76e-04 . acacacTC TCACAAGACG chr2:16837529-16837549 9 1.76e-04 agctatac acatccac atat chr2:43446441-43446461 7 1.89e-04 acagat acacccaa acccac chr21:46324458-46324478 11 2.01e-04 cacctcacac tcatacac aa chr8:142414244-142414264 4 2.68e-04 ccc acacagac ctggggagc chr7:2354508-2354528 11 2.68e-04 ATTCATTCAT tcacccac tc chr4:79535274-79535294 1 3.00e-04 . CCACCCAC TCTGTATGTC chr14:106155294-10615531 10 3.37e-04 catacacct atatacac tca chr19:4815315-4815335 2 4.45e-04 t tcactcac tcgttcattc chr18:77723322-77723342 10 6.94e-04 ggccacaat ccccacac gcc chr7:2354718-2354738 13 6.94e-04 ctacattcat tcatccac chr5:17225148-17225168 1 7.16e-04 . ACACTCAT TTTGGAACTC chr1:32479135-32479155 10 7.86e-04 TCTCCCGCC CCACACTC CGC chr1:27951873-27951893 2 7.86e-04 C ATACTCAC CTGACCCACC chr11:537277-537297 13 8.62e-04 GCGCCTGCGC CCACCCAA chr13:70140407-70140427 13 9.09e-04 attaaagcca aaccacac -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:146860083-146860103 1.3e-05 7_[+1]_5 chr6:44228568-44228588 1.3e-05 9_[+1]_3 chr3:183262537-183262557 1.3e-05 4_[+1]_8 chr6:34641680-34641700 1.3e-05 7_[+1]_5 chrX:9979636-9979656 1.3e-05 11_[+1]_1 chr1:85425191-85425211 1.3e-05 10_[+1]_2 chr19:36705057-36705077 1.3e-05 6_[+1]_6 chr13:74707963-74707983 1.3e-05 12_[+1] chr19:12896101-12896121 1.3e-05 10_[+1]_2 chr18:11078053-11078073 1.3e-05 5_[+1]_7 chr18:74830732-74830752 1.3e-05 3_[+1]_9 chr17:5130608-5130628 1.3e-05 3_[+1]_9 chr15:74708662-74708682 1.3e-05 7_[+1]_5 chr12:56366865-56366885 1.3e-05 5_[+1]_7 chr3:16549186-16549206 1.3e-05 3_[+1]_9 chr6:11319764-11319784 1.3e-05 10_[+1]_2 chr7:6741929-6741949 1.3e-05 9_[+1]_3 chr5:150466186-150466206 2.3e-05 11_[+1]_1 chr10:106088821-10608884 2.3e-05 1_[+1]_11 chr11:47379776-47379796 2.3e-05 4_[+1]_8 chr17:8732708-8732728 2.3e-05 10_[+1]_2 chr7:150329096-150329116 3.3e-05 [+1]_12 chr10:135162794-13516281 3.3e-05 11_[+1]_1 chr19:7153183-7153203 3.3e-05 5_[+1]_7 chr11:111229249-11122926 3.3e-05 9_[+1]_3 chrX:1644989-1645009 5e-05 5_[+1]_7 chr8:129005504-129005524 5e-05 8_[+1]_4 chr3:194871560-194871580 6.3e-05 12_[+1] chr15:60771243-60771263 8e-05 [+1]_12 chr12:14518351-14518371 0.00011 11_[+1]_1 chr6:167344019-167344039 0.00011 [+1]_12 chr3:127406265-127406285 0.00015 2_[+1]_10 chr1:154580222-154580242 0.00018 [+1]_12 chr2:16837529-16837549 0.00018 8_[+1]_4 chr2:43446441-43446461 0.00019 6_[+1]_6 chr21:46324458-46324478 0.0002 10_[+1]_2 chr8:142414244-142414264 0.00027 3_[+1]_9 chr7:2354508-2354528 0.00027 10_[+1]_2 chr4:79535274-79535294 0.0003 [+1]_12 chr14:106155294-10615531 0.00034 9_[+1]_3 chr19:4815315-4815335 0.00044 1_[+1]_11 chr18:77723322-77723342 0.00069 9_[+1]_3 chr7:2354718-2354738 0.00069 12_[+1] chr5:17225148-17225168 0.00072 [+1]_12 chr1:32479135-32479155 0.00079 9_[+1]_3 chr1:27951873-27951893 0.00079 1_[+1]_11 chr11:537277-537297 0.00086 12_[+1] chr13:70140407-70140427 0.00091 12_[+1] -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ACACACAC width=8 seqs=48 chr4:146860083-146860103 ( 8) ACACACAC 1 chr6:44228568-44228588 ( 10) ACACACAC 1 chr3:183262537-183262557 ( 5) ACACACAC 1 chr6:34641680-34641700 ( 8) ACACACAC 1 chrX:9979636-9979656 ( 12) ACACACAC 1 chr1:85425191-85425211 ( 11) ACACACAC 1 chr19:36705057-36705077 ( 7) ACACACAC 1 chr13:74707963-74707983 ( 13) ACACACAC 1 chr19:12896101-12896121 ( 11) ACACACAC 1 chr18:11078053-11078073 ( 6) ACACACAC 1 chr18:74830732-74830752 ( 4) ACACACAC 1 chr17:5130608-5130628 ( 4) ACACACAC 1 chr15:74708662-74708682 ( 8) ACACACAC 1 chr12:56366865-56366885 ( 6) ACACACAC 1 chr3:16549186-16549206 ( 4) ACACACAC 1 chr6:11319764-11319784 ( 11) ACACACAC 1 chr7:6741929-6741949 ( 10) ACACACAC 1 chr5:150466186-150466206 ( 12) ACATACAC 1 chr10:106088821-10608884 ( 2) ACATACAC 1 chr11:47379776-47379796 ( 5) ACATACAC 1 chr17:8732708-8732728 ( 11) ACATACAC 1 chr7:150329096-150329116 ( 1) ACACACAA 1 chr10:135162794-13516281 ( 12) ACACACAA 1 chr19:7153183-7153203 ( 6) ACACACAA 1 chr11:111229249-11122926 ( 10) ACACACAA 1 chrX:1644989-1645009 ( 6) ACACCCAC 1 chr8:129005504-129005524 ( 9) ACACCCAC 1 chr3:194871560-194871580 ( 13) TCACACAC 1 chr15:60771243-60771263 ( 1) CCACACAC 1 chr12:14518351-14518371 ( 12) AAACACAC 1 chr6:167344019-167344039 ( 1) ACACACAT 1 chr3:127406265-127406285 ( 3) ACCCACAC 1 chr1:154580222-154580242 ( 1) ACACACTC 1 chr2:16837529-16837549 ( 9) ACATCCAC 1 chr2:43446441-43446461 ( 7) ACACCCAA 1 chr21:46324458-46324478 ( 11) TCATACAC 1 chr8:142414244-142414264 ( 4) ACACAGAC 1 chr7:2354508-2354528 ( 11) TCACCCAC 1 chr4:79535274-79535294 ( 1) CCACCCAC 1 chr14:106155294-10615531 ( 10) ATATACAC 1 chr19:4815315-4815335 ( 2) TCACTCAC 1 chr18:77723322-77723342 ( 10) CCCCACAC 1 chr7:2354718-2354738 ( 13) TCATCCAC 1 chr5:17225148-17225168 ( 1) ACACTCAT 1 chr1:32479135-32479155 ( 10) CCACACTC 1 chr1:27951873-27951893 ( 2) ATACTCAC 1 chr11:537277-537297 ( 13) CCACCCAA 1 chr13:70140407-70140427 ( 13) AACCACAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.98246 E= 2.1e-045 188 -141 -1223 -114 -236 172 -1223 -246 213 -215 -1223 -1223 -1223 159 -1223 -47 184 -74 -1223 -188 -1223 182 -373 -1223 216 -1223 -1223 -246 -78 159 -1223 -246 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 48 E= 2.1e-045 0.791667 0.104167 0.000000 0.104167 0.041667 0.916667 0.000000 0.041667 0.937500 0.062500 0.000000 0.000000 0.000000 0.833333 0.000000 0.166667 0.770833 0.166667 0.000000 0.062500 0.000000 0.979167 0.020833 0.000000 0.958333 0.000000 0.000000 0.041667 0.125000 0.833333 0.000000 0.041667 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-1 regular expression -------------------------------------------------------------------------------- ACACACAC -------------------------------------------------------------------------------- Time 1.96 secs. ******************************************************************************** ******************************************************************************** MOTIF TGTGTGTG MEME-2 width = 8 sites = 36 llr = 310 E-value = 4.9e-035 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-2 Description -------------------------------------------------------------------------------- Simplified A 1::1:::: pos.-specific C :111:::: probability G 29:8:a:a matrix T 8:91a:a: bits 2.2 2.0 * * 1.8 **** 1.6 ** **** Relative 1.3 ** **** Entropy 1.1 *** **** (12.4 bits) 0.9 *** **** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TGTGTGTG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr14:103571586-10357160 13 1.65e-05 AGTTGGGGGg tgtgtgtg chr1:201405041-201405061 11 1.65e-05 cctgtgtgtg tgtgtgtg tg chr10:45464497-45464517 1 1.65e-05 . tgtgtgtg ttgagtgtga chr17:38697608-38697628 13 1.65e-05 tctgtgtttg tgtgtgtg chr7:154997779-154997799 8 1.65e-05 gtgtgtc tgtgtgtg cccgc chr16:21946484-21946504 13 1.65e-05 tgtgtgtgtg tgtgtgtg chr11:65196969-65196989 11 1.65e-05 tgtgtgtgtg tgtgtgtg tg chr8:38627459-38627479 7 1.65e-05 gtatgg tgtgtgtg tgtgag chr1:207097621-207097641 2 1.65e-05 g tgtgtgtg gtgtgtggct chr19:6532533-6532553 6 1.65e-05 gttcg tgtgtgtg ttcgtgt chr1:236313478-236313498 4 1.65e-05 gtt tgtgtgtg tctgtgtgc chr12:121533775-12153379 3 1.65e-05 CT TGTGTGTG CAACTGTGCG chr2:123617026-123617046 11 1.65e-05 tgtgaatatg tgtgtgtg aa chr1:209943909-209943929 5 1.65e-05 agaa tgtgtgtg catgtgga chr17:72247416-72247436 8 1.65e-05 tctgtga tgtgtgtg gtgtg chr7:143083157-143083177 4 1.65e-05 gta tgtgtgtg tgcatgtga chr22:44550771-44550791 13 3.63e-05 tgtagtgtgt ggtgtgtg chr21:45668442-45668462 3 3.63e-05 ca ggtgtgtg gatgagcgtg chr10:3142200-3142220 8 3.63e-05 tgtgtgg ggtgtgtg tatat chr16:84982799-84982819 6 5.29e-05 gtgca tgtctgtg tggtttt chr19:7705060-7705080 3 5.29e-05 tc tgtctgtg tgcatgtgtg chr14:106151474-10615149 3 6.65e-05 tg tgtttgtg tgtctctgtg chr2:234073943-234073963 9 7.93e-05 tgagtcta tgtatgtg agtc chr22:37704636-37704656 10 7.93e-05 gagtgtgca tgtatgtg tgC chr17:74511817-74511837 11 9.92e-05 GCGTAAAATG TGCGTGTG CA chr1:207097416-207097436 13 1.15e-04 tgctgtgtct agtgtgtg chr10:3153314-3153334 9 1.15e-04 tttgagat agtgtgtg catg chr2:237484237-237484257 12 1.31e-04 GGGGTTGTGC TCtgtgtg t chr1:181478129-181478149 1 1.47e-04 . TGTGTGAG TGCTAGAGGT chr19:38086124-38086144 4 1.66e-04 gtg ggtctgtg cgcgcgcgt chr14:73714317-73714337 12 1.86e-04 ATCGTGGCAG TGGGTGTG G chr21:45379239-45379259 10 2.23e-04 ggcatgtgt ggtttgtg gtg chr4:154409286-154409306 7 2.23e-04 GTTGTG GGTTTGTG GCTGAG chr7:1043508-1043528 8 2.23e-04 GGAGTCC TGTGGGTG GGGAG chr16:27460839-27460859 4 2.82e-04 ACG TGCCTGTG GGCCTGGGA chr20:37626347-37626367 12 5.14e-04 GGGTTGTGGG TCCGTGTG T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr14:103571586-10357160 1.6e-05 12_[+2] chr1:201405041-201405061 1.6e-05 10_[+2]_2 chr10:45464497-45464517 1.6e-05 [+2]_12 chr17:38697608-38697628 1.6e-05 12_[+2] chr7:154997779-154997799 1.6e-05 7_[+2]_5 chr16:21946484-21946504 1.6e-05 12_[+2] chr11:65196969-65196989 1.6e-05 10_[+2]_2 chr8:38627459-38627479 1.6e-05 6_[+2]_6 chr1:207097621-207097641 1.6e-05 1_[+2]_11 chr19:6532533-6532553 1.6e-05 5_[+2]_7 chr1:236313478-236313498 1.6e-05 3_[+2]_9 chr12:121533775-12153379 1.6e-05 2_[+2]_10 chr2:123617026-123617046 1.6e-05 10_[+2]_2 chr1:209943909-209943929 1.6e-05 4_[+2]_8 chr17:72247416-72247436 1.6e-05 7_[+2]_5 chr7:143083157-143083177 1.6e-05 3_[+2]_9 chr22:44550771-44550791 3.6e-05 12_[+2] chr21:45668442-45668462 3.6e-05 2_[+2]_10 chr10:3142200-3142220 3.6e-05 7_[+2]_5 chr16:84982799-84982819 5.3e-05 5_[+2]_7 chr19:7705060-7705080 5.3e-05 2_[+2]_10 chr14:106151474-10615149 6.7e-05 2_[+2]_10 chr2:234073943-234073963 7.9e-05 8_[+2]_4 chr22:37704636-37704656 7.9e-05 9_[+2]_3 chr17:74511817-74511837 9.9e-05 10_[+2]_2 chr1:207097416-207097436 0.00011 12_[+2] chr10:3153314-3153334 0.00011 8_[+2]_4 chr2:237484237-237484257 0.00013 11_[+2]_1 chr1:181478129-181478149 0.00015 [+2]_12 chr19:38086124-38086144 0.00017 3_[+2]_9 chr14:73714317-73714337 0.00019 11_[+2]_1 chr21:45379239-45379259 0.00022 9_[+2]_3 chr4:154409286-154409306 0.00022 6_[+2]_6 chr7:1043508-1043528 0.00022 7_[+2]_5 chr16:27460839-27460859 0.00028 3_[+2]_9 chr20:37626347-37626367 0.00051 11_[+2]_1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGTGTGTG width=8 seqs=36 chr14:103571586-10357160 ( 13) TGTGTGTG 1 chr1:201405041-201405061 ( 11) TGTGTGTG 1 chr10:45464497-45464517 ( 1) TGTGTGTG 1 chr17:38697608-38697628 ( 13) TGTGTGTG 1 chr7:154997779-154997799 ( 8) TGTGTGTG 1 chr16:21946484-21946504 ( 13) TGTGTGTG 1 chr11:65196969-65196989 ( 11) TGTGTGTG 1 chr8:38627459-38627479 ( 7) TGTGTGTG 1 chr1:207097621-207097641 ( 2) TGTGTGTG 1 chr19:6532533-6532553 ( 6) TGTGTGTG 1 chr1:236313478-236313498 ( 4) TGTGTGTG 1 chr12:121533775-12153379 ( 3) TGTGTGTG 1 chr2:123617026-123617046 ( 11) TGTGTGTG 1 chr1:209943909-209943929 ( 5) TGTGTGTG 1 chr17:72247416-72247436 ( 8) TGTGTGTG 1 chr7:143083157-143083177 ( 4) TGTGTGTG 1 chr22:44550771-44550791 ( 13) GGTGTGTG 1 chr21:45668442-45668462 ( 3) GGTGTGTG 1 chr10:3142200-3142220 ( 8) GGTGTGTG 1 chr16:84982799-84982819 ( 6) TGTCTGTG 1 chr19:7705060-7705080 ( 3) TGTCTGTG 1 chr14:106151474-10615149 ( 3) TGTTTGTG 1 chr2:234073943-234073963 ( 9) TGTATGTG 1 chr22:37704636-37704656 ( 10) TGTATGTG 1 chr17:74511817-74511837 ( 11) TGCGTGTG 1 chr1:207097416-207097436 ( 13) AGTGTGTG 1 chr10:3153314-3153334 ( 9) AGTGTGTG 1 chr2:237484237-237484257 ( 12) TCTGTGTG 1 chr1:181478129-181478149 ( 1) TGTGTGAG 1 chr19:38086124-38086144 ( 4) GGTCTGTG 1 chr14:73714317-73714337 ( 12) TGGGTGTG 1 chr21:45379239-45379259 ( 10) GGTTTGTG 1 chr4:154409286-154409306 ( 7) GGTTTGTG 1 chr7:1043508-1043528 ( 8) TGTGGGTG 1 chr16:27460839-27460859 ( 4) TGCCTGTG 1 chr20:37626347-37626367 ( 12) TCCGTGTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.89464 E= 4.9e-035 -195 -1181 -73 176 -1181 -232 177 -1181 -1181 -173 -332 195 -195 -132 143 -147 -1181 -1181 -332 208 -1181 -1181 185 -1181 -295 -1181 -1181 208 -1181 -1181 185 -1181 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 36 E= 4.9e-035 0.055556 0.000000 0.166667 0.777778 0.000000 0.055556 0.944444 0.000000 0.000000 0.083333 0.027778 0.888889 0.055556 0.111111 0.750000 0.083333 0.000000 0.000000 0.027778 0.972222 0.000000 0.000000 1.000000 0.000000 0.027778 0.000000 0.000000 0.972222 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-2 regular expression -------------------------------------------------------------------------------- TGTGTGTG -------------------------------------------------------------------------------- Time 2.69 secs. ******************************************************************************** ******************************************************************************** MOTIF TGACGTCA MEME-3 width = 8 sites = 10 llr = 96 E-value = 1.8e-001 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGACGTCA MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::8::::a pos.-specific C :2:8::a: probability G :82:a::: matrix T a::2:a:: bits 2.2 * * * 2.0 * * * 1.8 * **** 1.6 * **** Relative 1.3 * * **** Entropy 1.1 ******** (13.9 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TGACGTCA consensus CGT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr14:23388123-23388143 5 1.45e-05 CCCG TGACGTCA GGGGGGAG chr1:936293-936313 5 1.45e-05 GGGA TGACGTCA TGTGGCCC chr19:50979530-50979550 1 1.45e-05 . TGACGTCA TGATGCGGAG chr19:50862228-50862248 4 1.45e-05 ATA TGACGTCA CTATGGCGT chr5:95297773-95297793 11 1.45e-05 TAATCATGTC TGACGTCA CG chr17:72510402-72510422 1 2.65e-05 . tgatgtca tgtgatgggt chr17:72510203-72510223 8 2.65e-05 tgatgca tgatgtca tgtga chr5:78810426-78810446 4 4.11e-05 AGC TCACGTCA CCGAGGTGC chr12:58138391-58138411 8 5.97e-05 AAAACAA TGGCGTCA TCGTG chr17:42264285-42264305 6 1.06e-04 CAGCT TCGCGTCA TCAGTGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr14:23388123-23388143 1.5e-05 4_[+3]_8 chr1:936293-936313 1.5e-05 4_[+3]_8 chr19:50979530-50979550 1.5e-05 [+3]_12 chr19:50862228-50862248 1.5e-05 3_[+3]_9 chr5:95297773-95297793 1.5e-05 10_[+3]_2 chr17:72510402-72510422 2.6e-05 [+3]_12 chr17:72510203-72510223 2.6e-05 7_[+3]_5 chr5:78810426-78810446 4.1e-05 3_[+3]_9 chr12:58138391-58138411 6e-05 7_[+3]_5 chr17:42264285-42264305 0.00011 5_[+3]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGACGTCA width=8 seqs=10 chr14:23388123-23388143 ( 5) TGACGTCA 1 chr1:936293-936313 ( 5) TGACGTCA 1 chr19:50979530-50979550 ( 1) TGACGTCA 1 chr19:50862228-50862248 ( 4) TGACGTCA 1 chr5:95297773-95297793 ( 11) TGACGTCA 1 chr17:72510402-72510422 ( 1) TGATGTCA 1 chr17:72510203-72510223 ( 8) TGATGTCA 1 chr5:78810426-78810446 ( 4) TCACGTCA 1 chr12:58138391-58138411 ( 8) TGGCGTCA 1 chr17:42264285-42264305 ( 6) TCGCGTCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.5921 E= 1.8e-001 -997 -997 -997 212 -997 -47 153 -997 190 -997 -47 -997 -997 153 -997 -20 -997 -997 185 -997 -997 -997 -997 212 -997 185 -997 -997 222 -997 -997 -997 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 10 E= 1.8e-001 0.000000 0.000000 0.000000 1.000000 0.000000 0.200000 0.800000 0.000000 0.800000 0.000000 0.200000 0.000000 0.000000 0.800000 0.000000 0.200000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-3 regular expression -------------------------------------------------------------------------------- T[GC][AG][CT]GTCA -------------------------------------------------------------------------------- Time 4.24 secs. ******************************************************************************** ******************************************************************************** MOTIF GATGGATG MEME-4 width = 8 sites = 10 llr = 92 E-value = 6.0e+000 ******************************************************************************** -------------------------------------------------------------------------------- Motif GATGGATG MEME-4 Description -------------------------------------------------------------------------------- Simplified A 2a3::81: pos.-specific C :::::::: probability G 8::aa2:a matrix T ::7:::9: bits 2.2 * 2.0 * 1.8 * ** * 1.6 * ** ** Relative 1.3 ******* Entropy 1.1 ******** (13.3 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GATGGATG consensus A A G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATGGATG MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr5:426682-426702 3 1.44e-05 aa gatggatg ggtaggtgca chr10:11325977-11325997 11 1.44e-05 gtgggtggat gatggatg ag chr8:11417903-11417923 8 1.44e-05 atggatg gatggatg catgg chr11:1914960-1914980 12 1.44e-05 tgggtagatg gatggatg g chr6:31939758-31939778 11 2.79e-05 GCCAGAGGCC GAAGGATG CA chr16:57064444-57064464 11 3.90e-05 tgaaaagatg aatggatg ga chr17:72510402-72510422 12 5.76e-05 gatgtcatgt gatgggtg g chr11:1883122-1883142 2 5.76e-05 g gatgggtg aacggatgga chr11:1937232-1937252 7 6.80e-05 tggttg aaaggatg gacaga chr1:228674438-228674458 12 1.26e-04 GCGGGTCCCT GAAGGAAG G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATGGATG MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr5:426682-426702 1.4e-05 2_[+4]_10 chr10:11325977-11325997 1.4e-05 10_[+4]_2 chr8:11417903-11417923 1.4e-05 7_[+4]_5 chr11:1914960-1914980 1.4e-05 11_[+4]_1 chr6:31939758-31939778 2.8e-05 10_[+4]_2 chr16:57064444-57064464 3.9e-05 10_[+4]_2 chr17:72510402-72510422 5.8e-05 11_[+4]_1 chr11:1883122-1883142 5.8e-05 1_[+4]_11 chr11:1937232-1937252 6.8e-05 6_[+4]_6 chr1:228674438-228674458 0.00013 11_[+4]_1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATGGATG MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GATGGATG width=8 seqs=10 chr5:426682-426702 ( 3) GATGGATG 1 chr10:11325977-11325997 ( 11) GATGGATG 1 chr8:11417903-11417923 ( 8) GATGGATG 1 chr11:1914960-1914980 ( 12) GATGGATG 1 chr6:31939758-31939778 ( 11) GAAGGATG 1 chr16:57064444-57064464 ( 11) AATGGATG 1 chr17:72510402-72510422 ( 12) GATGGGTG 1 chr11:1883122-1883142 ( 2) GATGGGTG 1 chr11:1937232-1937252 ( 7) AAAGGATG 1 chr1:228674438-228674458 ( 12) GAAGGAAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATGGATG MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.2854 E= 6.0e+000 -10 -997 153 -997 222 -997 -997 -997 48 -997 -997 160 -997 -997 185 -997 -997 -997 185 -997 190 -997 -47 -997 -110 -997 -997 197 -997 -997 185 -997 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATGGATG MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 10 E= 6.0e+000 0.200000 0.000000 0.800000 0.000000 1.000000 0.000000 0.000000 0.000000 0.300000 0.000000 0.000000 0.700000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.800000 0.000000 0.200000 0.000000 0.100000 0.000000 0.000000 0.900000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATGGATG MEME-4 regular expression -------------------------------------------------------------------------------- [GA]A[TA]GG[AG]TG -------------------------------------------------------------------------------- Time 7.33 secs. ******************************************************************************** ******************************************************************************** MOTIF ACACACAC MEME-5 width = 8 sites = 5 llr = 51 E-value = 2.1e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif ACACACAC MEME-5 Description -------------------------------------------------------------------------------- Simplified A a:8:a:a: pos.-specific C :8:a:a:a probability G ::2::::: matrix T :2:::::: bits 2.2 * * * 2.0 * * * 1.8 * ***** 1.6 * ***** Relative 1.3 * ****** Entropy 1.1 ******** (14.8 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel ACACACAC consensus TG sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr6:44228568-44228588 2 1.28e-05 c acacacac acacacacac chr3:183262537-183262557 13 1.28e-05 acacacacac acacacac chrX:9979636-9979656 2 1.28e-05 c acacacac gcacacacac chr3:16549186-16549206 12 2.33e-05 aaacacacac atacacac a chr3:194871560-194871580 1 3.98e-05 . acgcacac tctctcacac -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr6:44228568-44228588 1.3e-05 1_[+5]_11 chr3:183262537-183262557 1.3e-05 12_[+5] chrX:9979636-9979656 1.3e-05 1_[+5]_11 chr3:16549186-16549206 2.3e-05 11_[+5]_1 chr3:194871560-194871580 4e-05 [+5]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ACACACAC width=8 seqs=5 chr6:44228568-44228588 ( 2) ACACACAC 1 chr3:183262537-183262557 ( 13) ACACACAC 1 chrX:9979636-9979656 ( 2) ACACACAC 1 chr3:16549186-16549206 ( 12) ATACACAC 1 chr3:194871560-194871580 ( 1) ACGCACAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.59397 E= 2.1e+003 222 -897 -897 -897 -897 153 -897 -20 189 -897 -47 -897 -897 185 -897 -897 222 -897 -897 -897 -897 185 -897 -897 222 -897 -897 -897 -897 185 -897 -897 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 5 E= 2.1e+003 1.000000 0.000000 0.000000 0.000000 0.000000 0.800000 0.000000 0.200000 0.800000 0.000000 0.200000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACACACAC MEME-5 regular expression -------------------------------------------------------------------------------- A[CT][AG]CACAC -------------------------------------------------------------------------------- Time 10.48 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:6717104-6717124 6.86e-01 20 chr2:237484237-237484257 1.19e-01 20 chr11:1937232-1937252 1.71e-02 6_[+4(6.80e-05)]_6 chr7:143083157-143083177 5.74e-03 3_[+2(1.65e-05)]_9 chrX:1572519-1572539 9.28e-01 20 chr10:3153314-3153334 7.04e-02 20 chr11:1914960-1914980 2.50e-02 7_[+4(1.44e-05)]_5 chr19:7705060-7705080 3.21e-02 2_[+2(5.29e-05)]_10 chr16:57064444-57064464 8.43e-02 10_[+4(3.90e-05)]_2 chr7:6741929-6741949 1.32e-04 5_[+1(1.28e-05)]_7 chr11:111229249-11122926 9.51e-04 9_[+1(3.32e-05)]_3 chr19:4815315-4815335 6.58e-02 20 chr2:11244402-11244422 5.37e-01 20 chr8:11417903-11417923 2.29e-02 3_[+4(1.44e-05)]_9 chr17:38708388-38708408 7.40e-01 20 chr7:1043508-1043528 8.29e-02 20 chr17:72247416-72247436 8.77e-04 7_[+2(1.65e-05)]_5 chr9:114790698-114790718 1.23e-01 20 chr3:127406265-127406285 4.85e-03 20 chr12:6717329-6717349 9.02e-01 20 chr2:96810040-96810060 8.29e-01 20 chr6:167344019-167344039 2.09e-03 20 chr19:38086124-38086144 1.37e-01 20 chr10:3142200-3142220 2.36e-02 7_[+2(3.63e-05)]_5 chr13:28713610-28713630 5.39e-01 20 chr7:140624881-140624901 7.95e-01 20 chr6:11319764-11319784 3.83e-05 10_[+1(1.28e-05)]_2 chr3:16549186-16549206 1.04e-04 3_[+1(1.28e-05)]_[+5(2.33e-05)]_1 chr21:45394449-45394469 4.10e-01 20 chr12:56366865-56366885 2.30e-05 5_[+1(1.28e-05)]_7 chr21:46324458-46324478 1.37e-02 20 chr2:16837529-16837549 8.72e-03 20 chr8:131297137-131297157 5.99e-01 20 chr12:58138391-58138411 2.37e-02 7_[+3(5.97e-05)]_5 chr19:18061380-18061400 3.65e-01 20 chr1:209943909-209943929 5.27e-03 4_[+2(1.65e-05)]_8 chr12:6722352-6722372 9.41e-01 20 chr14:73714317-73714337 3.60e-03 20 chr19:10341232-10341252 9.93e-01 20 chr1:46806743-46806763 1.82e-01 20 chr17:8732708-8732728 2.41e-04 10_[+1(2.33e-05)]_2 chrX:9983151-9983171 6.27e-01 20 chr5:17225148-17225168 2.94e-02 20 chr4:57303388-57303408 8.01e-01 20 chr19:3360760-3360780 3.99e-01 20 chr6:37537385-37537405 2.30e-01 20 chr21:45668442-45668462 1.70e-02 2_[+2(3.63e-05)]_10 chr11:75063047-75063067 2.83e-01 20 chr2:43446441-43446461 1.45e-02 20 chr2:123617026-123617046 1.41e-02 8_[+2(1.65e-05)]_4 chr10:11325977-11325997 4.25e-03 10_[+4(1.44e-05)]_2 chr17:72510203-72510223 5.17e-04 7_[+3(2.65e-05)]_5 chr15:74708662-74708682 1.34e-04 1_[+1(1.28e-05)]_[+1(1.28e-05)]_3 chr1:228674438-228674458 1.47e-02 20 chr2:55276275-55276295 1.51e-01 20 chr9:123964404-123964424 9.68e-01 20 chr7:2354718-2354738 2.09e-01 20 chr17:5130608-5130628 1.26e-04 1_[+1(1.28e-05)]_11 chr17:76130330-76130350 1.53e-01 20 chr3:9932715-9932735 8.39e-01 20 chr12:121533775-12153379 3.39e-02 2_[+2(1.65e-05)]_10 chr10:80827476-80827496 8.39e-01 20 chr19:56159832-56159852 8.52e-01 20 chr7:102920884-102920904 1.80e-01 20 chr4:178230800-178230820 9.62e-01 20 chr1:224180332-224180352 6.28e-01 20 chr1:236313478-236313498 4.02e-02 3_[+2(1.65e-05)]_9 chr3:11684395-11684415 3.95e-01 20 chr15:38856440-38856460 1.76e-01 20 chr7:65958522-65958542 6.33e-01 20 chr18:77723322-77723342 7.28e-02 20 chr14:36278613-36278633 8.68e-01 20 chr19:6532533-6532553 2.07e-02 5_[+2(1.65e-05)]_7 chr18:12990294-12990314 6.05e-01 20 chr5:95297773-95297793 7.79e-03 10_[+3(1.45e-05)]_2 chr19:50862228-50862248 3.71e-02 3_[+3(1.45e-05)]_9 chr5:107300591-107300611 4.66e-01 20 chr18:74830732-74830752 8.10e-05 3_[+1(1.28e-05)]_9 chr13:28605819-28605839 5.79e-01 20 chr6:34664819-34664839 9.64e-01 20 chr2:243028653-243028673 8.69e-01 20 chr6:40219465-40219485 4.17e-01 20 chr6:7202445-7202465 8.97e-01 20 chr5:464270-464290 4.83e-01 20 chr17:2303491-2303511 4.72e-01 20 chr15:90727588-90727608 1.88e-01 20 chr1:151170894-151170914 7.97e-01 20 chr22:44550771-44550791 1.34e-02 12_[+2(3.63e-05)] chr7:2354508-2354528 4.62e-02 20 chr11:65153903-65153923 1.42e-01 20 chr21:45632066-45632086 2.46e-01 20 chr2:28114133-28114153 1.74e-01 20 chr12:121107479-12110749 4.93e-01 20 chr8:145682235-145682255 7.32e-01 20 chr1:243265060-243265080 2.25e-01 20 chr19:50979530-50979550 2.23e-02 [+3(1.45e-05)]_12 chr18:11078053-11078073 8.10e-05 1_[+1(1.28e-05)]_3_[+1(7.98e-05)] chr16:81831386-81831406 4.21e-01 20 chr3:53197295-53197315 5.99e-01 20 chr6:36648367-36648387 3.53e-01 20 chr1:2187510-2187530 2.32e-01 20 chr1:1136990-1137010 9.55e-01 20 chr3:58188871-58188891 5.98e-01 20 chr8:95003861-95003881 2.93e-01 20 chr1:207097416-207097436 5.94e-02 20 chr1:181478129-181478149 1.42e-01 20 chr6:13454944-13454964 5.78e-02 20 chr11:47379776-47379796 1.46e-03 4_[+1(2.33e-05)]_8 chr19:12896101-12896121 8.28e-05 10_[+1(1.28e-05)]_2 chr14:106151474-10615149 9.30e-02 2_[+2(6.65e-05)]_10 chr22:31892103-31892123 3.30e-01 20 chr14:106155294-10615531 1.60e-02 20 chr10:106088821-10608884 1.20e-04 1_[+1(2.33e-05)]_11 chr5:426682-426702 4.12e-03 2_[+4(1.44e-05)]_10 chr12:54144892-54144912 3.44e-01 20 chr15:74907242-74907262 6.51e-01 20 chr17:77770792-77770812 7.43e-01 20 chr8:354898-354918 3.06e-01 20 chr6:56911288-56911308 5.93e-01 20 chr8:142414244-142414264 5.16e-03 20 chr2:74781563-74781583 8.03e-01 20 chr12:6723186-6723206 2.57e-01 20 chr1:156698674-156698694 3.40e-01 20 chr19:2841158-2841178 7.41e-01 20 chr13:74707963-74707983 1.32e-04 8_[+1(1.28e-05)]_4 chr1:207097621-207097641 7.77e-03 1_[+2(1.65e-05)]_11 chr11:77185463-77185483 6.69e-01 20 chr1:27951873-27951893 8.57e-03 20 chr1:936293-936313 1.45e-02 4_[+3(1.45e-05)]_8 chr8:38627459-38627479 7.77e-03 6_[+2(1.65e-05)]_6 chr7:148844307-148844327 5.91e-01 20 chr16:29679329-29679349 1.13e-01 20 chr2:43453107-43453127 1.43e-01 20 chr3:186743194-186743214 8.44e-01 20 chr3:165557596-165557616 5.62e-01 20 chr1:154580222-154580242 4.59e-03 20 chr5:139032361-139032381 3.50e-01 20 chr18:77793329-77793349 9.50e-01 20 chr1:100503514-100503534 2.15e-01 20 chr17:74511817-74511837 6.87e-02 10_[+2(9.92e-05)]_2 chr21:38446201-38446221 7.97e-01 20 chr14:69260850-69260870 6.39e-01 20 chr8:41347812-41347832 3.94e-01 20 chr17:27055642-27055662 1.01e-01 20 chrX:1325033-1325053 9.94e-01 20 chr16:88851990-88852010 9.10e-01 20 chr11:65196969-65196989 5.34e-02 [+2(1.65e-05)]_[+2(1.65e-05)]_4 chr16:21946484-21946504 5.34e-02 [+2(1.65e-05)]_[+2(1.65e-05)]_4 chr19:36705057-36705077 6.26e-05 4_[+1(1.28e-05)]_8 chr4:186317250-186317270 3.89e-01 20 chr7:154997779-154997799 2.83e-02 7_[+2(1.65e-05)]_5 chr19:10381186-10381206 5.10e-01 20 chr15:84588296-84588316 3.46e-01 20 chr19:50490580-50490600 6.44e-01 20 chr4:8174012-8174032 7.59e-01 20 chr1:85425191-85425211 8.56e-05 10_[+1(1.28e-05)]_2 chr8:129005504-129005524 1.64e-03 8_[+1(4.97e-05)]_4 chr16:4466866-4466886 9.40e-01 20 chr13:33776917-33776937 2.73e-01 20 chr5:107007971-107007991 6.73e-01 20 chr9:139513120-139513140 8.31e-01 20 chr5:150466186-150466206 5.45e-04 11_[+1(2.33e-05)]_1 chr9:100174157-100174177 6.74e-01 20 chr17:38697608-38697628 4.01e-02 [+2(5.29e-05)]_2_[+2(1.65e-05)]_2 chr10:45464497-45464517 1.73e-02 [+2(1.65e-05)]_12 chr7:66310008-66310028 9.97e-01 20 chr17:6918149-6918169 4.82e-01 20 chr6:33176153-33176173 9.24e-01 20 chr2:9614460-9614480 6.42e-01 20 chr1:201405041-201405061 5.34e-02 2_[+2(1.65e-05)]_[+2(1.65e-05)]_2 chr22:37704636-37704656 2.34e-02 9_[+2(7.93e-05)]_3 chr4:87857639-87857659 3.72e-01 20 chr16:11171887-11171907 5.21e-01 20 chr10:14646790-14646810 8.82e-01 20 chr22:50969556-50969576 9.65e-01 20 chr5:173700512-173700532 1.31e-01 20 chrX:1644989-1645009 2.22e-03 5_[+1(4.97e-05)]_7 chr3:47143071-47143091 9.06e-01 20 chr19:45909223-45909243 4.28e-01 20 chr7:76009525-76009545 9.90e-01 20 chr19:2945288-2945308 5.61e-01 20 chr6:31939758-31939778 5.23e-02 10_[+4(2.79e-05)]_2 chr12:46777609-46777629 7.88e-01 20 chr1:32479135-32479155 7.95e-02 20 chr14:23388123-23388143 3.81e-03 4_[+3(1.45e-05)]_8 chr17:42786069-42786089 5.96e-01 20 chr21:43430367-43430387 3.85e-01 20 chr5:130970803-130970823 9.51e-01 20 chr4:79535274-79535294 2.94e-03 20 chr7:5534553-5534573 8.61e-02 20 chr19:7153183-7153203 9.16e-04 5_[+1(3.32e-05)]_7 chr10:135162794-13516281 1.43e-03 11_[+1(3.32e-05)]_1 chr19:42787562-42787582 2.17e-01 20 chr20:37626347-37626367 2.96e-01 20 chr3:5025565-5025585 5.86e-01 20 chr1:12261851-12261871 7.87e-01 20 chrX:1643488-1643508 4.48e-01 20 chr11:107550101-10755012 3.26e-01 20 chr19:4769683-4769703 7.10e-01 20 chrX:9979636-9979656 1.29e-04 1_[+1(1.28e-05)]_2_[+1(1.28e-05)]_1 chr19:5322334-5322354 2.73e-01 20 chr2:37194113-37194133 9.41e-01 20 chr16:88878538-88878558 6.10e-01 20 chr7:150329096-150329116 1.40e-03 [+1(3.32e-05)]_12 chr19:10514907-10514927 2.71e-01 20 chr21:45378525-45378545 4.12e-01 20 chr5:78810426-78810446 3.63e-02 3_[+3(4.11e-05)]_9 chr6:34641680-34641700 1.33e-04 1_[+1(1.28e-05)]_[+1(1.28e-05)]_3 chrX:47493383-47493403 9.08e-01 20 chr6:53213810-53213830 9.75e-01 20 chr16:84982799-84982819 2.64e-02 5_[+2(5.29e-05)]_7 chr19:10542634-10542654 6.89e-01 20 chr3:183262537-183262557 1.34e-04 [+1(1.28e-05)]_[+1(1.28e-05)]_4 chr14:103571586-10357160 1.76e-02 12_[+2(1.65e-05)] chr8:28259055-28259075 6.42e-01 20 chr16:27460839-27460859 2.62e-01 20 chr6:86352874-86352894 5.17e-01 20 chr6:44228568-44228588 1.34e-04 1_[+1(1.28e-05)]_[+1(1.28e-05)]_3 chr10:75385940-75385960 6.62e-01 20 chr16:19079330-19079350 9.26e-01 20 chr4:146860083-146860103 4.91e-05 7_[+1(1.28e-05)]_5 chr1:169680916-169680936 8.39e-01 20 chr9:37145018-37145038 3.31e-01 20 chr6:140864211-140864231 6.47e-01 20 chr6:45799331-45799351 1.82e-01 20 chr4:154409286-154409306 1.49e-01 20 chr19:1668378-1668398 4.72e-01 20 chr17:42264285-42264305 1.24e-01 20 chr13:70140407-70140427 1.19e-02 20 chr16:68504439-68504459 4.74e-01 20 chr11:537277-537297 1.27e-01 20 chr15:60771243-60771263 3.89e-03 [+1(7.98e-05)]_12 chr3:13415603-13415623 3.26e-01 20 chr2:28974377-28974397 1.00e+00 20 chr2:68694763-68694783 7.32e-01 20 chr11:1883122-1883142 3.84e-02 1_[+4(5.76e-05)]_11 chr8:103567742-103567762 7.51e-01 20 chr14:102780792-10278081 5.24e-01 20 chr2:127434935-127434955 4.66e-01 20 chr3:194871560-194871580 8.20e-04 [+5(3.98e-05)]_4_[+1(6.33e-05)] chr11:93245415-93245435 3.98e-01 20 chr5:137673223-137673243 5.02e-01 20 chr11:64099283-64099303 7.32e-01 20 chr12:14518351-14518371 1.32e-03 11_[+5(7.60e-05)]_1 chr2:219745048-219745068 2.84e-01 20 chrX:84748030-84748050 3.99e-01 20 chr17:72510402-72510422 1.65e-04 [+3(2.65e-05)]_3_[+4(5.76e-05)]_1 chr2:100107109-100107129 4.51e-01 20 chr2:234073943-234073963 1.61e-02 8_[+2(7.93e-05)]_4 chr21:45379239-45379259 8.07e-02 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n09.farnam.hpc.yale.internal ********************************************************************************