******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/REST.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr1:38230130-38230150 1.0000 20 chr3:38847457-38847477 1.0000 20 chr11:74925588-74925608 1.0000 20 chr6:88146311-88146331 1.0000 20 chr1:11919528-11919548 1.0000 20 chr19:55028867-55028887 1.0000 20 chr1:107678267-107678287 1.0000 20 chr19:5404240-5404260 1.0000 20 chr1:31655319-31655339 1.0000 20 chr10:50815162-50815182 1.0000 20 chr7:126747967-126747987 1.0000 20 chr20:1986651-1986671 1.0000 20 chr10:26656934-26656954 1.0000 20 chr5:133877584-133877604 1.0000 20 chr16:9025883-9025903 1.0000 20 chr11:116476443-11647646 1.0000 20 chr13:53424932-53424952 1.0000 20 chr8:67089868-67089888 1.0000 20 chr14:77675216-77675236 1.0000 20 chr20:47139878-47139898 1.0000 20 chr16:89992899-89992919 1.0000 20 chr22:39941959-39941979 1.0000 20 chr10:125374600-12537462 1.0000 20 chr8:56015576-56015596 1.0000 20 chr5:75400067-75400087 1.0000 20 chr1:47201574-47201594 1.0000 20 chr2:220173037-220173057 1.0000 20 chr12:113503210-11350323 1.0000 20 chr9:140779173-140779193 1.0000 20 chr2:73518398-73518418 1.0000 20 chr2:217237080-217237100 1.0000 20 chr1:33352328-33352348 1.0000 20 chr17:56197755-56197775 1.0000 20 chr16:2765628-2765648 1.0000 20 chr20:37314683-37314703 1.0000 20 chr2:47798602-47798622 1.0000 20 chr7:100701852-100701872 1.0000 20 chr16:24869951-24869971 1.0000 20 chr10:73555160-73555180 1.0000 20 chr14:82542106-82542126 1.0000 20 chr22:31198908-31198928 1.0000 20 chr10:86051351-86051371 1.0000 20 chr15:73639254-73639274 1.0000 20 chr15:83332068-83332088 1.0000 20 chr12:101220296-10122031 1.0000 20 chr20:5892344-5892364 1.0000 20 chr10:16654438-16654458 1.0000 20 chr9:139941190-139941210 1.0000 20 chr19:36319758-36319778 1.0000 20 chr3:42341667-42341687 1.0000 20 chr2:219827747-219827767 1.0000 20 chr22:39220697-39220717 1.0000 20 chr1:32189541-32189561 1.0000 20 chr6:89248008-89248028 1.0000 20 chr19:3244200-3244220 1.0000 20 chr20:31797728-31797748 1.0000 20 chr14:77600272-77600292 1.0000 20 chr2:44243613-44243633 1.0000 20 chr17:29721784-29721804 1.0000 20 chr22:44263893-44263913 1.0000 20 chr18:47425014-47425034 1.0000 20 chr7:31154762-31154782 1.0000 20 chr12:108608449-10860846 1.0000 20 chr2:73110669-73110689 1.0000 20 chr8:54790569-54790589 1.0000 20 chr15:91730670-91730690 1.0000 20 chr8:142970867-142970887 1.0000 20 chr19:52056627-52056647 1.0000 20 chr20:43408978-43408998 1.0000 20 chr11:117467995-11746801 1.0000 20 chr5:95770034-95770054 1.0000 20 chr12:53135348-53135368 1.0000 20 chr5:176038530-176038550 1.0000 20 chr9:119760731-119760751 1.0000 20 chr16:10989384-10989404 1.0000 20 chr3:2345433-2345453 1.0000 20 chr15:70268901-70268921 1.0000 20 chr14:90961802-90961822 1.0000 20 chr14:78996581-78996601 1.0000 20 chr9:134674743-134674763 1.0000 20 chr20:37321205-37321225 1.0000 20 chr6:88930434-88930454 1.0000 20 chr2:42018855-42018875 1.0000 20 chr2:16727599-16727619 1.0000 20 chr15:51973702-51973722 1.0000 20 chr5:33936198-33936218 1.0000 20 chr6:12752119-12752139 1.0000 20 chr8:41753572-41753592 1.0000 20 chr16:89104144-89104164 1.0000 20 chr3:42743094-42743114 1.0000 20 chr9:36748501-36748521 1.0000 20 chr6:35773080-35773100 1.0000 20 chr6:24127171-24127191 1.0000 20 chr3:10795857-10795877 1.0000 20 chr12:100933173-10093319 1.0000 20 chr6:110299901-110299921 1.0000 20 chr10:105038749-10503876 1.0000 20 chr10:105025667-10502568 1.0000 20 chr1:169565184-169565204 1.0000 20 chr16:750791-750811 1.0000 20 chr5:14628657-14628677 1.0000 20 chr1:11610909-11610929 1.0000 20 chr8:129157329-129157349 1.0000 20 chr3:139516767-139516787 1.0000 20 chr5:141123134-141123154 1.0000 20 chr14:79329687-79329707 1.0000 20 chr3:179754578-179754598 1.0000 20 chr19:7627881-7627901 1.0000 20 chr9:134989672-134989692 1.0000 20 chr12:119499197-11949921 1.0000 20 chr3:137916131-137916151 1.0000 20 chr17:27333050-27333070 1.0000 20 chr20:44669707-44669727 1.0000 20 chr5:141114578-141114598 1.0000 20 chr15:89905082-89905102 1.0000 20 chr1:34966235-34966255 1.0000 20 chr7:30711660-30711680 1.0000 20 chr19:45999752-45999772 1.0000 20 chr7:150681156-150681176 1.0000 20 chr6:101844616-101844636 1.0000 20 chr4:6364829-6364849 1.0000 20 chr1:210111113-210111133 1.0000 20 chr1:155248169-155248189 1.0000 20 chr15:83378287-83378307 1.0000 20 chr12:67587673-67587693 1.0000 20 chr1:20003078-20003098 1.0000 20 chr1:37389990-37390010 1.0000 20 chr22:37040474-37040494 1.0000 20 chr5:132901861-132901881 1.0000 20 chr8:65292631-65292651 1.0000 20 chr15:66297174-66297194 1.0000 20 chr6:39105220-39105240 1.0000 20 chr19:4173197-4173217 1.0000 20 chr15:74557566-74557586 1.0000 20 chr13:84456235-84456255 1.0000 20 chr19:36466709-36466729 1.0000 20 chr12:113229372-11322939 1.0000 20 chr5:139188343-139188363 1.0000 20 chr19:42644481-42644501 1.0000 20 chr14:93389878-93389898 1.0000 20 chr6:146349536-146349556 1.0000 20 chr16:88627321-88627341 1.0000 20 chr1:110698725-110698745 1.0000 20 chr11:123524783-12352480 1.0000 20 chr7:104192739-104192759 1.0000 20 chr6:90605211-90605231 1.0000 20 chr16:22652566-22652586 1.0000 20 chr11:1423010-1423030 1.0000 20 chr17:42385974-42385994 1.0000 20 chr12:108862269-10886228 1.0000 20 chr1:175694982-175695002 1.0000 20 chr1:38261216-38261236 1.0000 20 chr1:7135567-7135587 1.0000 20 chr2:227675936-227675956 1.0000 20 chr20:37309340-37309360 1.0000 20 chr1:23999753-23999773 1.0000 20 chr11:22359301-22359321 1.0000 20 chr22:30112914-30112934 1.0000 20 chr10:88066599-88066619 1.0000 20 chr1:210900135-210900155 1.0000 20 chr15:48483234-48483254 1.0000 20 chr20:41816578-41816598 1.0000 20 chr17:64825832-64825852 1.0000 20 chr1:37486445-37486465 1.0000 20 chr11:119645077-11964509 1.0000 20 chr12:3601561-3601581 1.0000 20 chr17:6173026-6173046 1.0000 20 chr14:78986390-78986410 1.0000 20 chr22:21364067-21364087 1.0000 20 chr11:116250330-11625035 1.0000 20 chr1:204806782-204806802 1.0000 20 chr1:38541894-38541914 1.0000 20 chr3:178402852-178402872 1.0000 20 chr8:62408875-62408895 1.0000 20 chr2:59061738-59061758 1.0000 20 chr1:18582994-18583014 1.0000 20 chr3:9746098-9746118 1.0000 20 chr10:87963451-87963471 1.0000 20 chr14:78865836-78865856 1.0000 20 chr5:174749104-174749124 1.0000 20 chr8:62200786-62200806 1.0000 20 chr19:40089951-40089971 1.0000 20 chr10:122273722-12227374 1.0000 20 chr11:57652949-57652969 1.0000 20 chr3:187387621-187387641 1.0000 20 chr19:55728500-55728520 1.0000 20 chr19:13552867-13552887 1.0000 20 chr2:171670863-171670883 1.0000 20 chr16:9930168-9930188 1.0000 20 chr2:137340384-137340404 1.0000 20 chr10:97151911-97151931 1.0000 20 chr5:16179057-16179077 1.0000 20 chr12:77527527-77527547 1.0000 20 chr1:50774693-50774713 1.0000 20 chr1:48996640-48996660 1.0000 20 chr22:26655672-26655692 1.0000 20 chr9:122133302-122133322 1.0000 20 chrX:12567062-12567082 1.0000 20 chr10:104121647-10412166 1.0000 20 chr11:126431368-12643138 1.0000 20 chr22:47184518-47184538 1.0000 20 chr1:37721192-37721212 1.0000 20 chr15:70265652-70265672 1.0000 20 chr16:24267369-24267389 1.0000 20 chr4:6227292-6227312 1.0000 20 chr18:55021283-55021303 1.0000 20 chr20:61713806-61713826 1.0000 20 chr2:64524037-64524057 1.0000 20 chr2:219910856-219910876 1.0000 20 chr9:34984238-34984258 1.0000 20 chr1:44434188-44434208 1.0000 20 chr17:45863251-45863271 1.0000 20 chr5:161495678-161495698 1.0000 20 chr6:127837397-127837417 1.0000 20 chr7:32467491-32467511 1.0000 20 chr16:1238890-1238910 1.0000 20 chr4:170745057-170745077 1.0000 20 chr3:49905373-49905393 1.0000 20 chr1:74968277-74968297 1.0000 20 chr9:119568544-119568564 1.0000 20 chr14:89444308-89444328 1.0000 20 chr1:209323651-209323671 1.0000 20 chr1:95850311-95850331 1.0000 20 chr16:68478155-68478175 1.0000 20 chr1:235812371-235812391 1.0000 20 chr1:65775597-65775617 1.0000 20 chr15:89962788-89962808 1.0000 20 chrX:18165295-18165315 1.0000 20 chr20:33815022-33815042 1.0000 20 chr3:115044595-115044615 1.0000 20 chr19:43106162-43106182 1.0000 20 chr7:8157003-8157023 1.0000 20 chr4:147565172-147565192 1.0000 20 chr5:1409624-1409644 1.0000 20 chr3:54222375-54222395 1.0000 20 chr2:119924829-119924849 1.0000 20 chr5:6328434-6328454 1.0000 20 chr2:29516876-29516896 1.0000 20 chr1:7676600-7676620 1.0000 20 chr11:47294447-47294467 1.0000 20 chr6:37493728-37493748 1.0000 20 chr19:55948893-55948913 1.0000 20 chr19:18344116-18344136 1.0000 20 chrX:74151197-74151217 1.0000 20 chr8:28514905-28514925 1.0000 20 chr20:45152795-45152815 1.0000 20 chr9:34494126-34494146 1.0000 20 chr17:6207185-6207205 1.0000 20 chr20:62793400-62793420 1.0000 20 chr16:56048040-56048060 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_REST/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/REST.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.195 C 0.307 G 0.315 T 0.183 Background letter frequencies (from file dataset with add-one prior applied): A 0.195 C 0.307 G 0.315 T 0.183 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF WCCATGGW MEME-1 width = 8 sites = 111 llr = 820 E-value = 9.9e-137 ******************************************************************************** -------------------------------------------------------------------------------- Motif WCCATGGW MEME-1 Description -------------------------------------------------------------------------------- Simplified A 5::61::5 pos.-specific C :aa12::: probability G :::21aa: matrix T 5::16::5 bits 2.4 2.2 2.0 1.7 ** * Relative 1.5 *** ** Entropy 1.2 *** *** (10.7 bits) 1.0 *** *** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel ACCATGGA consensus T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCCATGGW MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:74151197-74151217 9 1.27e-05 AGGACAGT ACCATGGA CAGA chr4:147565172-147565192 4 1.27e-05 AGT ACCATGGA TAGTAACCG chr1:65775597-65775617 9 1.27e-05 GCGCCAGC ACCATGGA CAGC chr14:89444308-89444328 2 1.27e-05 G ACCATGGA CAGTAACCAC chr9:119568544-119568564 2 1.27e-05 G ACCATGGA CAGCACAAGG chr7:104192739-104192759 10 1.27e-05 CGTGTCAGC ACCATGGA CAG chr19:36466709-36466729 8 1.27e-05 GATCAGA ACCATGGA CAGCA chr5:132901861-132901881 5 1.27e-05 CAGC ACCATGGA CAGCAGCA chr1:20003078-20003098 6 1.27e-05 TCAGC ACCATGGA CAAGACA chr4:6364829-6364849 9 1.27e-05 GGGTCAGC ACCATGGA CAGA chr3:137916131-137916151 6 1.27e-05 CAAGC ACCATGGA TAGCTCC chr19:7627881-7627901 6 1.27e-05 TCAGC ACCATGGA CAGGGAT chr9:36748501-36748521 5 1.27e-05 CAGC ACCATGGA CAGTGGCA chr2:42018855-42018875 3 1.27e-05 GC ACCATGGA CAGCATCTCT chr7:31154762-31154782 1 1.27e-05 . ACCATGGA GAGAGCCAAG chr17:29721784-29721804 8 1.27e-05 gggcagg accatgga caggg chr2:44243613-44243633 2 1.27e-05 C ACCATGGA CAGCGAGGCA chr19:36319758-36319778 4 1.27e-05 AGC ACCATGGA CAGCGCTTT chr15:83332068-83332088 8 1.27e-05 TTTCAGC ACCATGGA CAGCG chr10:73555160-73555180 10 1.27e-05 TTGGTCAGG ACCATGGA GAG chr16:24869951-24869971 11 1.27e-05 CTCGTTCAGG ACCATGGA GA chr7:100701852-100701872 10 1.27e-05 GGGTTCAGT ACCATGGA CAG chr10:125374600-12537462 10 1.27e-05 GTGGTCAGC ACCATGGA CAG chr6:88146311-88146331 7 1.27e-05 GTCAGG ACCATGGA CAGCTC chr3:49905373-49905393 13 4.77e-05 CCAGGAGCTA TCCATGGT chr16:9930168-9930188 8 4.77e-05 TACGCTG TCCATGGT TCTGA chr11:116250330-11625035 10 4.77e-05 AGTCTGCTG TCCATGGT GCT chr14:78986390-78986410 1 4.77e-05 . TCCATGGT GCTGAAACAT chr5:141123134-141123154 5 4.77e-05 CCTG TCCATGGT GCTAACCC chr10:105025667-10502568 7 4.77e-05 GAGCTG TCCATGGT CTTGAA chr15:70268901-70268921 11 4.77e-05 TGTGCCTCTG TCCATGGT TC chr12:108608449-10860846 12 4.77e-05 AGGGTGGCTG TCCATGGT G chr10:16654438-16654458 7 4.77e-05 GCTCTG TCCATGGT CCTGAA chr12:101220296-10122031 11 4.77e-05 TTGGGTGCTG TCCATGGT AC chr17:56197755-56197775 8 4.77e-05 GCTACTG TCCATGGT CCTGA chr14:77675216-77675236 9 4.77e-05 TGGTGCTG TCCATGGT GCTG chr7:126747967-126747987 12 4.77e-05 CTTGGAGCTG TCCATGGT G chr3:54222375-54222395 2 6.12e-05 C ACCAAGGA CAGCGACATG chr1:7135567-7135587 10 6.12e-05 TGGTTCAGC ACCAAGGA CAG chr1:210111113-210111133 5 6.12e-05 TTCA ACCAAGGA GACCTGTC chr12:53135348-53135368 2 6.12e-05 C ACCAAGGA CAGAGCACCG chr1:107678267-107678287 3 6.12e-05 GC ACCAAGGA CAGTTCCCAG chr16:56048040-56048060 11 1.71e-04 CCGCTGCAGC ACCACGGA CA chr19:43106162-43106182 7 1.71e-04 GTGCTG TCCAAGGT GCTGCT chr1:209323651-209323671 2 1.71e-04 G ACCACGGA CAGAAACACA chr4:170745057-170745077 5 1.71e-04 GCTA TCCAAGGT ACTGGCCT chr11:126431368-12643138 7 1.71e-04 TTCAGC ACCACGGA CAGAGG chrX:12567062-12567082 9 1.71e-04 GGCTCAGC ACCTTGGA CAGT chr10:97151911-97151931 12 1.71e-04 CTGGAGCAGC ACCACGGA C chr2:227675936-227675956 1 1.71e-04 . ACCACGGA GAGCGCAAGG chr19:4173197-4173217 12 1.71e-04 CGACTTCAGC ACCTTGGA G chr22:37040474-37040494 2 1.71e-04 C TCCAAGGT GCTGAAGCAA chr7:150681156-150681176 11 1.71e-04 TTTGTCTCTG TCCAAGGT GC chr12:100933173-10093319 5 1.71e-04 actg tccaaggt gctggagt chr2:16727599-16727619 2 1.71e-04 C TCCAAGGT GCTGAATCAA chr16:10989384-10989404 3 1.71e-04 GC ACCACGGA CAGCTCCCAC chr20:31797728-31797748 2 1.71e-04 C ACCACGGA CAGCAGTCAC chr14:82542106-82542126 4 1.71e-04 AGC ACCTTGGA CAGCACCAG chr12:113503210-11350323 4 1.71e-04 AGT ACCTTGGA CAGCACCAT chr22:39941959-39941979 11 1.71e-04 GGAATTCAGC ACCACGGA CA chr16:9025883-9025903 11 1.71e-04 CTGATTCAGC ACCACGGA CA chr20:1986651-1986671 2 1.71e-04 C ACCACGGA CAGCGATTGG chr11:74925588-74925608 11 1.71e-04 AGATGTCAGC ACCTTGGA CA chr5:141114578-141114598 13 2.22e-04 GCTGTTCAGG ACCTTGGT chr2:119924829-119924849 11 2.71e-04 CCTGCCGCTG TCCGTGGT GC chr1:95850311-95850331 8 2.71e-04 GGAACTG TCCGTGGT GCTGA chr2:64524037-64524057 11 2.71e-04 CATGCCTCTG TCCGTGGT TC chr19:40089951-40089971 9 2.71e-04 TGGTGCTG TCCGTGGT GCTG chr1:18582994-18583014 1 2.71e-04 . TCCGTGGT GCTGATAGTT chr11:22359301-22359321 2 2.71e-04 G TCCGTGGT GCTGAAACAT chr6:101844616-101844636 8 2.71e-04 AGCGCTG TCCGTGGT CCTGA chr20:37321205-37321225 7 2.71e-04 ACGCTG TCCGTGGT GCTGAC chr20:43408978-43408998 13 2.71e-04 GCAGGAACTG TCCGTGGT chr19:5404240-5404260 1 2.71e-04 . TCCGTGGT ACTGAACGGT chr1:11919528-11919548 7 2.71e-04 CCGCTG TCCGTGGT GCTGAT chr19:55948893-55948913 6 3.00e-04 CACTG TCCACGGT CCTGAAC chr19:55728500-55728520 9 3.00e-04 TGGCGCTG TCCTTGGT GCTG chr1:23999753-23999773 10 3.00e-04 cgggcactg tccttggt gct chr20:44669707-44669727 13 3.00e-04 GAGACCGCTG TCCACGGT chr3:139516767-139516787 9 3.00e-04 GAGCGCTG TCCTTGGT GCTG chr5:161495678-161495698 10 3.22e-04 TGGTTCAGC ACCAGGGA CAG chr1:44434188-44434208 4 3.22e-04 AGC ACCAGGGA CAGCTCCTG chr20:61713806-61713826 8 3.22e-04 CTTCAGC ACCAGGGA GGCGG chr8:142970867-142970887 11 3.22e-04 ctgtttcagc accaggga ca chr5:139188343-139188363 1 3.83e-04 . ACCCTGGA CAGCGCCCCA chr12:67587673-67587693 4 3.83e-04 AGG ACCCTGGA CAGCTCTAC chr1:32189541-32189561 7 3.83e-04 TTCAGC ACCCTGGA CAGCAG chr5:133877584-133877604 9 3.83e-04 GAGTCAGG ACCCTGGA CAGG chr14:78865836-78865856 5 4.21e-04 GCTG TCCAGGGT GCTGGACT chr6:39105220-39105240 12 4.21e-04 CATGGAGCTC TCCAGGGT G chr14:79329687-79329707 1 4.21e-04 . TCCAGGGT GCTGAACGTG chr22:30112914-30112934 12 4.57e-04 CTGGGAGCTC TCCCTGGT G chr15:74557566-74557586 7 4.57e-04 CTGCTG TCCCTGGT GCTGAA chr1:175694982-175695002 8 5.34e-04 attcagc acctagga cagtt chr1:169565184-169565204 3 5.73e-04 TG TCCATTGT CCTGAAGGTC chr3:115044595-115044615 4 6.38e-04 CTG TCCGAGGT TCTGAACTA chr20:5892344-5892364 12 6.38e-04 GCCGGTCAGC ACCGCGGA C chr2:47798602-47798622 9 6.38e-04 GCGTCAGC ACCGCGGA CAGC chr20:37314683-37314703 1 6.38e-04 . TCCGAGGT GCTGACGGCT chr17:42385974-42385994 8 7.02e-04 GCTCAGC ACCTCGGA GAGCT chr2:73518398-73518418 8 7.53e-04 GGAACTG TCCGCGGA GCTGG chr22:44263893-44263913 9 8.02e-04 GGTCGCTG TCCGCGGT GCTG chr22:31198908-31198928 12 8.02e-04 CTGGACGCTG TCCGCGGT G chr2:220173037-220173057 11 8.02e-04 GCTGGCGCTG TCCGCGGT GC chr7:32467491-32467511 2 8.76e-04 C ACCGGGGA CAGCTCCTGC chr14:77600272-77600292 6 8.76e-04 TCAGA ACCCAGGA CAGCTCC chr4:6227292-6227312 4 1.12e-03 CTC TCCGGGGT GCTGAAAGG chr19:55028867-55028887 11 1.20e-03 TAGTTTCAGC ACCATGGC CA chr15:91730670-91730690 11 1.35e-03 AAGGTCACTG TCCAATGT GC chr17:6207185-6207205 6 1.44e-03 TCAGC ACCCGGGA CAGCACC chr10:122273722-12227374 5 1.44e-03 GCTG TCCGTTGT GCTGAATG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCCATGGW MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:74151197-74151217 1.3e-05 8_[+1]_4 chr4:147565172-147565192 1.3e-05 3_[+1]_9 chr1:65775597-65775617 1.3e-05 8_[+1]_4 chr14:89444308-89444328 1.3e-05 1_[+1]_11 chr9:119568544-119568564 1.3e-05 1_[+1]_11 chr7:104192739-104192759 1.3e-05 9_[+1]_3 chr19:36466709-36466729 1.3e-05 7_[+1]_5 chr5:132901861-132901881 1.3e-05 4_[+1]_8 chr1:20003078-20003098 1.3e-05 5_[+1]_7 chr4:6364829-6364849 1.3e-05 8_[+1]_4 chr3:137916131-137916151 1.3e-05 5_[+1]_7 chr19:7627881-7627901 1.3e-05 5_[+1]_7 chr9:36748501-36748521 1.3e-05 4_[+1]_8 chr2:42018855-42018875 1.3e-05 2_[+1]_10 chr7:31154762-31154782 1.3e-05 [+1]_12 chr17:29721784-29721804 1.3e-05 7_[+1]_5 chr2:44243613-44243633 1.3e-05 1_[+1]_11 chr19:36319758-36319778 1.3e-05 3_[+1]_9 chr15:83332068-83332088 1.3e-05 7_[+1]_5 chr10:73555160-73555180 1.3e-05 9_[+1]_3 chr16:24869951-24869971 1.3e-05 10_[+1]_2 chr7:100701852-100701872 1.3e-05 9_[+1]_3 chr10:125374600-12537462 1.3e-05 9_[+1]_3 chr6:88146311-88146331 1.3e-05 6_[+1]_6 chr3:49905373-49905393 4.8e-05 12_[+1] chr16:9930168-9930188 4.8e-05 7_[+1]_5 chr11:116250330-11625035 4.8e-05 9_[+1]_3 chr14:78986390-78986410 4.8e-05 [+1]_12 chr5:141123134-141123154 4.8e-05 4_[+1]_8 chr10:105025667-10502568 4.8e-05 6_[+1]_6 chr15:70268901-70268921 4.8e-05 10_[+1]_2 chr12:108608449-10860846 4.8e-05 11_[+1]_1 chr10:16654438-16654458 4.8e-05 6_[+1]_6 chr12:101220296-10122031 4.8e-05 10_[+1]_2 chr17:56197755-56197775 4.8e-05 7_[+1]_5 chr14:77675216-77675236 4.8e-05 8_[+1]_4 chr7:126747967-126747987 4.8e-05 11_[+1]_1 chr3:54222375-54222395 6.1e-05 1_[+1]_11 chr1:7135567-7135587 6.1e-05 9_[+1]_3 chr1:210111113-210111133 6.1e-05 4_[+1]_8 chr12:53135348-53135368 6.1e-05 1_[+1]_11 chr1:107678267-107678287 6.1e-05 2_[+1]_10 chr16:56048040-56048060 0.00017 10_[+1]_2 chr19:43106162-43106182 0.00017 6_[+1]_6 chr1:209323651-209323671 0.00017 1_[+1]_11 chr4:170745057-170745077 0.00017 4_[+1]_8 chr11:126431368-12643138 0.00017 6_[+1]_6 chrX:12567062-12567082 0.00017 8_[+1]_4 chr10:97151911-97151931 0.00017 11_[+1]_1 chr2:227675936-227675956 0.00017 [+1]_12 chr19:4173197-4173217 0.00017 11_[+1]_1 chr22:37040474-37040494 0.00017 1_[+1]_11 chr7:150681156-150681176 0.00017 10_[+1]_2 chr12:100933173-10093319 0.00017 4_[+1]_8 chr2:16727599-16727619 0.00017 1_[+1]_11 chr16:10989384-10989404 0.00017 2_[+1]_10 chr20:31797728-31797748 0.00017 1_[+1]_11 chr14:82542106-82542126 0.00017 3_[+1]_9 chr12:113503210-11350323 0.00017 3_[+1]_9 chr22:39941959-39941979 0.00017 10_[+1]_2 chr16:9025883-9025903 0.00017 10_[+1]_2 chr20:1986651-1986671 0.00017 1_[+1]_11 chr11:74925588-74925608 0.00017 10_[+1]_2 chr5:141114578-141114598 0.00022 12_[+1] chr2:119924829-119924849 0.00027 10_[+1]_2 chr1:95850311-95850331 0.00027 7_[+1]_5 chr2:64524037-64524057 0.00027 10_[+1]_2 chr19:40089951-40089971 0.00027 8_[+1]_4 chr1:18582994-18583014 0.00027 [+1]_12 chr11:22359301-22359321 0.00027 1_[+1]_11 chr6:101844616-101844636 0.00027 7_[+1]_5 chr20:37321205-37321225 0.00027 6_[+1]_6 chr20:43408978-43408998 0.00027 12_[+1] chr19:5404240-5404260 0.00027 [+1]_12 chr1:11919528-11919548 0.00027 6_[+1]_6 chr19:55948893-55948913 0.0003 5_[+1]_7 chr19:55728500-55728520 0.0003 8_[+1]_4 chr1:23999753-23999773 0.0003 9_[+1]_3 chr20:44669707-44669727 0.0003 12_[+1] chr3:139516767-139516787 0.0003 8_[+1]_4 chr5:161495678-161495698 0.00032 9_[+1]_3 chr1:44434188-44434208 0.00032 3_[+1]_9 chr20:61713806-61713826 0.00032 7_[+1]_5 chr8:142970867-142970887 0.00032 10_[+1]_2 chr5:139188343-139188363 0.00038 [+1]_12 chr12:67587673-67587693 0.00038 3_[+1]_9 chr1:32189541-32189561 0.00038 6_[+1]_6 chr5:133877584-133877604 0.00038 8_[+1]_4 chr14:78865836-78865856 0.00042 4_[+1]_8 chr6:39105220-39105240 0.00042 11_[+1]_1 chr14:79329687-79329707 0.00042 [+1]_12 chr22:30112914-30112934 0.00046 11_[+1]_1 chr15:74557566-74557586 0.00046 6_[+1]_6 chr1:175694982-175695002 0.00053 7_[+1]_5 chr1:169565184-169565204 0.00057 2_[+1]_10 chr3:115044595-115044615 0.00064 3_[+1]_9 chr20:5892344-5892364 0.00064 11_[+1]_1 chr2:47798602-47798622 0.00064 8_[+1]_4 chr20:37314683-37314703 0.00064 [+1]_12 chr17:42385974-42385994 0.0007 7_[+1]_5 chr2:73518398-73518418 0.00075 7_[+1]_5 chr22:44263893-44263913 0.0008 8_[+1]_4 chr22:31198908-31198928 0.0008 11_[+1]_1 chr2:220173037-220173057 0.0008 10_[+1]_2 chr7:32467491-32467511 0.00088 1_[+1]_11 chr14:77600272-77600292 0.00088 5_[+1]_7 chr4:6227292-6227312 0.0011 3_[+1]_9 chr19:55028867-55028887 0.0012 10_[+1]_2 chr15:91730670-91730690 0.0013 10_[+1]_2 chr17:6207185-6207205 0.0014 5_[+1]_7 chr10:122273722-12227374 0.0014 4_[+1]_8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCCATGGW MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF WCCATGGW width=8 seqs=111 chrX:74151197-74151217 ( 9) ACCATGGA 1 chr4:147565172-147565192 ( 4) ACCATGGA 1 chr1:65775597-65775617 ( 9) ACCATGGA 1 chr14:89444308-89444328 ( 2) ACCATGGA 1 chr9:119568544-119568564 ( 2) ACCATGGA 1 chr7:104192739-104192759 ( 10) ACCATGGA 1 chr19:36466709-36466729 ( 8) ACCATGGA 1 chr5:132901861-132901881 ( 5) ACCATGGA 1 chr1:20003078-20003098 ( 6) ACCATGGA 1 chr4:6364829-6364849 ( 9) ACCATGGA 1 chr3:137916131-137916151 ( 6) ACCATGGA 1 chr19:7627881-7627901 ( 6) ACCATGGA 1 chr9:36748501-36748521 ( 5) ACCATGGA 1 chr2:42018855-42018875 ( 3) ACCATGGA 1 chr7:31154762-31154782 ( 1) ACCATGGA 1 chr17:29721784-29721804 ( 8) ACCATGGA 1 chr2:44243613-44243633 ( 2) ACCATGGA 1 chr19:36319758-36319778 ( 4) ACCATGGA 1 chr15:83332068-83332088 ( 8) ACCATGGA 1 chr10:73555160-73555180 ( 10) ACCATGGA 1 chr16:24869951-24869971 ( 11) ACCATGGA 1 chr7:100701852-100701872 ( 10) ACCATGGA 1 chr10:125374600-12537462 ( 10) ACCATGGA 1 chr6:88146311-88146331 ( 7) ACCATGGA 1 chr3:49905373-49905393 ( 13) TCCATGGT 1 chr16:9930168-9930188 ( 8) TCCATGGT 1 chr11:116250330-11625035 ( 10) TCCATGGT 1 chr14:78986390-78986410 ( 1) TCCATGGT 1 chr5:141123134-141123154 ( 5) TCCATGGT 1 chr10:105025667-10502568 ( 7) TCCATGGT 1 chr15:70268901-70268921 ( 11) TCCATGGT 1 chr12:108608449-10860846 ( 12) TCCATGGT 1 chr10:16654438-16654458 ( 7) TCCATGGT 1 chr12:101220296-10122031 ( 11) TCCATGGT 1 chr17:56197755-56197775 ( 8) TCCATGGT 1 chr14:77675216-77675236 ( 9) TCCATGGT 1 chr7:126747967-126747987 ( 12) TCCATGGT 1 chr3:54222375-54222395 ( 2) ACCAAGGA 1 chr1:7135567-7135587 ( 10) ACCAAGGA 1 chr1:210111113-210111133 ( 5) ACCAAGGA 1 chr12:53135348-53135368 ( 2) ACCAAGGA 1 chr1:107678267-107678287 ( 3) ACCAAGGA 1 chr16:56048040-56048060 ( 11) ACCACGGA 1 chr19:43106162-43106182 ( 7) TCCAAGGT 1 chr1:209323651-209323671 ( 2) ACCACGGA 1 chr4:170745057-170745077 ( 5) TCCAAGGT 1 chr11:126431368-12643138 ( 7) ACCACGGA 1 chrX:12567062-12567082 ( 9) ACCTTGGA 1 chr10:97151911-97151931 ( 12) ACCACGGA 1 chr2:227675936-227675956 ( 1) ACCACGGA 1 chr19:4173197-4173217 ( 12) ACCTTGGA 1 chr22:37040474-37040494 ( 2) TCCAAGGT 1 chr7:150681156-150681176 ( 11) TCCAAGGT 1 chr12:100933173-10093319 ( 5) TCCAAGGT 1 chr2:16727599-16727619 ( 2) TCCAAGGT 1 chr16:10989384-10989404 ( 3) ACCACGGA 1 chr20:31797728-31797748 ( 2) ACCACGGA 1 chr14:82542106-82542126 ( 4) ACCTTGGA 1 chr12:113503210-11350323 ( 4) ACCTTGGA 1 chr22:39941959-39941979 ( 11) ACCACGGA 1 chr16:9025883-9025903 ( 11) ACCACGGA 1 chr20:1986651-1986671 ( 2) ACCACGGA 1 chr11:74925588-74925608 ( 11) ACCTTGGA 1 chr5:141114578-141114598 ( 13) ACCTTGGT 1 chr2:119924829-119924849 ( 11) TCCGTGGT 1 chr1:95850311-95850331 ( 8) TCCGTGGT 1 chr2:64524037-64524057 ( 11) TCCGTGGT 1 chr19:40089951-40089971 ( 9) TCCGTGGT 1 chr1:18582994-18583014 ( 1) TCCGTGGT 1 chr11:22359301-22359321 ( 2) TCCGTGGT 1 chr6:101844616-101844636 ( 8) TCCGTGGT 1 chr20:37321205-37321225 ( 7) TCCGTGGT 1 chr20:43408978-43408998 ( 13) TCCGTGGT 1 chr19:5404240-5404260 ( 1) TCCGTGGT 1 chr1:11919528-11919548 ( 7) TCCGTGGT 1 chr19:55948893-55948913 ( 6) TCCACGGT 1 chr19:55728500-55728520 ( 9) TCCTTGGT 1 chr1:23999753-23999773 ( 10) TCCTTGGT 1 chr20:44669707-44669727 ( 13) TCCACGGT 1 chr3:139516767-139516787 ( 9) TCCTTGGT 1 chr5:161495678-161495698 ( 10) ACCAGGGA 1 chr1:44434188-44434208 ( 4) ACCAGGGA 1 chr20:61713806-61713826 ( 8) ACCAGGGA 1 chr8:142970867-142970887 ( 11) ACCAGGGA 1 chr5:139188343-139188363 ( 1) ACCCTGGA 1 chr12:67587673-67587693 ( 4) ACCCTGGA 1 chr1:32189541-32189561 ( 7) ACCCTGGA 1 chr5:133877584-133877604 ( 9) ACCCTGGA 1 chr14:78865836-78865856 ( 5) TCCAGGGT 1 chr6:39105220-39105240 ( 12) TCCAGGGT 1 chr14:79329687-79329707 ( 1) TCCAGGGT 1 chr22:30112914-30112934 ( 12) TCCCTGGT 1 chr15:74557566-74557586 ( 7) TCCCTGGT 1 chr1:175694982-175695002 ( 8) ACCTAGGA 1 chr1:169565184-169565204 ( 3) TCCATTGT 1 chr3:115044595-115044615 ( 4) TCCGAGGT 1 chr20:5892344-5892364 ( 12) ACCGCGGA 1 chr2:47798602-47798622 ( 9) ACCGCGGA 1 chr20:37314683-37314703 ( 1) TCCGAGGT 1 chr17:42385974-42385994 ( 8) ACCTCGGA 1 chr2:73518398-73518418 ( 8) TCCGCGGA 1 chr22:44263893-44263913 ( 9) TCCGCGGT 1 chr22:31198908-31198928 ( 12) TCCGCGGT 1 chr2:220173037-220173057 ( 11) TCCGCGGT 1 chr7:32467491-32467511 ( 2) ACCGGGGA 1 chr14:77600272-77600292 ( 6) ACCCAGGA 1 chr4:6227292-6227312 ( 4) TCCGGGGT 1 chr19:55028867-55028887 ( 11) ACCATGGC 1 chr15:91730670-91730690 ( 11) TCCAATGT 1 chr17:6207185-6207205 ( 6) ACCCGGGA 1 chr10:122273722-12227374 ( 5) TCCGTTGT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCCATGGW MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 4.64866 E= 9.9e-137 149 -1344 -1344 130 -1344 170 -1344 -1344 -1344 170 -1344 -1344 169 -209 -67 -89 -44 -84 -180 170 -1344 -1344 163 -276 -1344 -1344 167 -1344 147 -509 -1344 130 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCCATGGW MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 111 E= 9.9e-137 0.549550 0.000000 0.000000 0.450450 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.630631 0.072072 0.198198 0.099099 0.144144 0.171171 0.090090 0.594595 0.000000 0.000000 0.972973 0.027027 0.000000 0.000000 1.000000 0.000000 0.540541 0.009009 0.000000 0.450450 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WCCATGGW MEME-1 regular expression -------------------------------------------------------------------------------- [AT]CCATGG[AT] -------------------------------------------------------------------------------- Time 2.26 secs. ******************************************************************************** ******************************************************************************** MOTIF HGCTGTCC MEME-2 width = 8 sites = 38 llr = 334 E-value = 2.2e-041 ******************************************************************************** -------------------------------------------------------------------------------- Motif HGCTGTCC MEME-2 Description -------------------------------------------------------------------------------- Simplified A 4::::::: pos.-specific C 3:a:1:aa probability G :a::91:: matrix T 3::a:9:: bits 2.4 * 2.2 * * 2.0 * * 1.7 ** ** Relative 1.5 *** *** Entropy 1.2 ******* (12.7 bits) 1.0 ******* 0.7 ******* 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AGCTGTCC consensus C sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HGCTGTCC MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:18344116-18344136 2 1.87e-05 G AGCTGTCC GCGCCGGAGG chr2:29516876-29516896 5 1.87e-05 GGGG AGCTGTCC ACAAAGTA chr5:1409624-1409644 1 1.87e-05 . AGCTGTCC AGGTGCTGAA chr19:13552867-13552887 10 1.87e-05 TGTGCTGGG AGCTGTCC AGG chr17:64825832-64825852 2 1.87e-05 G AGCTGTCC AGATGCTGAC chr20:37309340-37309360 10 1.87e-05 GACACTGTG AGCTGTCC AGG chr19:42644481-42644501 5 1.87e-05 AGGG AGCTGTCC AAAGGCTG chr6:12752119-12752139 3 1.87e-05 GG AGCTGTCC TCCCTTGGTG chr9:139941190-139941210 10 1.87e-05 GGAGCTGGG AGCTGTCC AAG chr20:47139878-47139898 9 1.87e-05 gagcactg agctgtcc tagg chr10:104121647-10412166 12 3.63e-05 CTCACAAAGC TGCTGTCC A chr22:26655672-26655692 10 3.63e-05 CATGCGGGG TGCTGTCC GCT chr1:48996640-48996660 6 3.63e-05 CTTGG TGCTGTCC TCCATCT chr11:57652949-57652969 6 3.63e-05 GAAAG TGCTGTCC AGTCACA chr3:9746098-9746118 10 3.63e-05 GATTTCCGG TGCTGTCC AGA chr16:88627321-88627341 4 3.63e-05 GGC TGCTGTCC TCCATGTGG chr13:84456235-84456255 7 3.63e-05 CCGAGG TGCTGTCC AGTTCC chr15:66297174-66297194 10 3.63e-05 GACCCGGTG TGCTGTCC TTG chr8:41753572-41753592 9 3.63e-05 CTGCCGGG TGCTGTCC AAGG chr20:62793400-62793420 13 6.59e-05 GGGGGGAGAG CGCTGTCC chr17:45863251-45863271 9 6.59e-05 GCGCTTTC CGCTGTCC ATGG chr5:16179057-16179077 12 6.59e-05 GGTAGGCGTG CGCTGTCC G chr2:171670863-171670883 5 6.59e-05 CGGG CGCTGTCC TTCGTGCT chr1:204806782-204806802 11 6.59e-05 AGGAGCTTGT CGCTGTCC AG chr10:88066599-88066619 12 6.59e-05 GTCTTCCTGG CGCTGTCC G chr8:65292631-65292651 11 6.59e-05 CCCTGCCTGG CGCTGTCC GC chr1:155248169-155248189 9 6.59e-05 GCTCTGGT CGCTGTCC CTAG chr6:89248008-89248028 13 6.59e-05 TGACAAAAGC CGCTGTCC chr16:2765628-2765648 13 6.59e-05 GCGCGGCGGG CGCTGTCC chr8:67089868-67089888 12 6.59e-05 TTCGGATGGG CGCTGTCC G chr16:68478155-68478175 8 8.41e-05 CTTGGAC AGCTCTCC TCCAC chr1:37389990-37390010 13 8.41e-05 ATGCGTTGGG AGCTCTCC chr1:74968277-74968297 5 1.54e-04 AGGG AGCTATCC AGAGTACT chr1:37721192-37721212 9 1.54e-04 GGGGAGGG GGCTGTCC GTGG chr5:14628657-14628677 2 1.65e-04 G AGCTGTCT GTGGTGCTGA chr9:34984238-34984258 7 3.24e-04 GATTGC CTCTGTCC AAAGTG chr16:89104144-89104164 4 3.24e-04 GGC TGCTGGCC CTCTCCGAG chr17:6173026-6173046 2 3.92e-04 C CGCTGGCC GTGGTGCTGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HGCTGTCC MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:18344116-18344136 1.9e-05 1_[+2]_11 chr2:29516876-29516896 1.9e-05 4_[+2]_8 chr5:1409624-1409644 1.9e-05 [+2]_12 chr19:13552867-13552887 1.9e-05 9_[+2]_3 chr17:64825832-64825852 1.9e-05 1_[+2]_11 chr20:37309340-37309360 1.9e-05 9_[+2]_3 chr19:42644481-42644501 1.9e-05 4_[+2]_8 chr6:12752119-12752139 1.9e-05 2_[+2]_10 chr9:139941190-139941210 1.9e-05 9_[+2]_3 chr20:47139878-47139898 1.9e-05 8_[+2]_4 chr10:104121647-10412166 3.6e-05 11_[+2]_1 chr22:26655672-26655692 3.6e-05 9_[+2]_3 chr1:48996640-48996660 3.6e-05 5_[+2]_7 chr11:57652949-57652969 3.6e-05 5_[+2]_7 chr3:9746098-9746118 3.6e-05 9_[+2]_3 chr16:88627321-88627341 3.6e-05 3_[+2]_9 chr13:84456235-84456255 3.6e-05 6_[+2]_6 chr15:66297174-66297194 3.6e-05 9_[+2]_3 chr8:41753572-41753592 3.6e-05 8_[+2]_4 chr20:62793400-62793420 6.6e-05 12_[+2] chr17:45863251-45863271 6.6e-05 8_[+2]_4 chr5:16179057-16179077 6.6e-05 11_[+2]_1 chr2:171670863-171670883 6.6e-05 4_[+2]_8 chr1:204806782-204806802 6.6e-05 10_[+2]_2 chr10:88066599-88066619 6.6e-05 11_[+2]_1 chr8:65292631-65292651 6.6e-05 10_[+2]_2 chr1:155248169-155248189 6.6e-05 8_[+2]_4 chr6:89248008-89248028 6.6e-05 12_[+2] chr16:2765628-2765648 6.6e-05 12_[+2] chr8:67089868-67089888 6.6e-05 11_[+2]_1 chr16:68478155-68478175 8.4e-05 7_[+2]_5 chr1:37389990-37390010 8.4e-05 12_[+2] chr1:74968277-74968297 0.00015 4_[+2]_8 chr1:37721192-37721212 0.00015 8_[+2]_4 chr5:14628657-14628677 0.00017 1_[+2]_11 chr9:34984238-34984258 0.00032 6_[+2]_6 chr16:89104144-89104164 0.00032 3_[+2]_9 chr17:6173026-6173046 0.00039 1_[+2]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HGCTGTCC MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF HGCTGTCC width=8 seqs=38 chr19:18344116-18344136 ( 2) AGCTGTCC 1 chr2:29516876-29516896 ( 5) AGCTGTCC 1 chr5:1409624-1409644 ( 1) AGCTGTCC 1 chr19:13552867-13552887 ( 10) AGCTGTCC 1 chr17:64825832-64825852 ( 2) AGCTGTCC 1 chr20:37309340-37309360 ( 10) AGCTGTCC 1 chr19:42644481-42644501 ( 5) AGCTGTCC 1 chr6:12752119-12752139 ( 3) AGCTGTCC 1 chr9:139941190-139941210 ( 10) AGCTGTCC 1 chr20:47139878-47139898 ( 9) AGCTGTCC 1 chr10:104121647-10412166 ( 12) TGCTGTCC 1 chr22:26655672-26655692 ( 10) TGCTGTCC 1 chr1:48996640-48996660 ( 6) TGCTGTCC 1 chr11:57652949-57652969 ( 6) TGCTGTCC 1 chr3:9746098-9746118 ( 10) TGCTGTCC 1 chr16:88627321-88627341 ( 4) TGCTGTCC 1 chr13:84456235-84456255 ( 7) TGCTGTCC 1 chr15:66297174-66297194 ( 10) TGCTGTCC 1 chr8:41753572-41753592 ( 9) TGCTGTCC 1 chr20:62793400-62793420 ( 13) CGCTGTCC 1 chr17:45863251-45863271 ( 9) CGCTGTCC 1 chr5:16179057-16179077 ( 12) CGCTGTCC 1 chr2:171670863-171670883 ( 5) CGCTGTCC 1 chr1:204806782-204806802 ( 11) CGCTGTCC 1 chr10:88066599-88066619 ( 12) CGCTGTCC 1 chr8:65292631-65292651 ( 11) CGCTGTCC 1 chr1:155248169-155248189 ( 9) CGCTGTCC 1 chr6:89248008-89248028 ( 13) CGCTGTCC 1 chr16:2765628-2765648 ( 13) CGCTGTCC 1 chr8:67089868-67089888 ( 12) CGCTGTCC 1 chr16:68478155-68478175 ( 8) AGCTCTCC 1 chr1:37389990-37390010 ( 13) AGCTCTCC 1 chr1:74968277-74968297 ( 5) AGCTATCC 1 chr1:37721192-37721212 ( 9) GGCTGTCC 1 chr5:14628657-14628677 ( 2) AGCTGTCT 1 chr9:34984238-34984258 ( 7) CTCTGTCC 1 chr16:89104144-89104164 ( 4) TGCTGGCC 1 chr17:6173026-6173046 ( 2) CGCTGGCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HGCTGTCC MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.5983 E= 2.2e-041 92 16 -358 52 -1189 -1189 163 -280 -1189 170 -1189 -1189 -1189 -1189 -1189 245 -289 -254 155 -1189 -1189 -1189 -258 237 -1189 170 -1189 -1189 -1189 167 -1189 -280 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HGCTGTCC MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 38 E= 2.2e-041 0.368421 0.342105 0.026316 0.263158 0.000000 0.000000 0.973684 0.026316 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.026316 0.052632 0.921053 0.000000 0.000000 0.000000 0.052632 0.947368 0.000000 1.000000 0.000000 0.000000 0.000000 0.973684 0.000000 0.026316 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif HGCTGTCC MEME-2 regular expression -------------------------------------------------------------------------------- [ACT]GCTGTCC -------------------------------------------------------------------------------- Time 5.53 secs. ******************************************************************************** ******************************************************************************** MOTIF CAGCDCCH MEME-3 width = 8 sites = 55 llr = 363 E-value = 3.0e-021 ******************************************************************************** -------------------------------------------------------------------------------- Motif CAGCDCCH MEME-3 Description -------------------------------------------------------------------------------- Simplified A :a::4::4 pos.-specific C 9::8:893 probability G 1:a:31:: matrix T :::131:2 bits 2.4 * 2.2 * 2.0 * 1.7 ** Relative 1.5 ** * Entropy 1.2 *** * (9.5 bits) 1.0 **** ** 0.7 **** ** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CAGCACCA consensus G C sequence T T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCDCCH MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:219910856-219910876 10 2.07e-05 CTCTATGAC CAGCACCA CGG chr3:187387621-187387641 13 2.07e-05 TTCCCAGGGT CAGCACCA chr11:1423010-1423030 5 2.07e-05 TGTC CAGCACCA GCCGTGCT chr12:119499197-11949921 11 2.07e-05 GACGGCGGTT CAGCACCA GG chr5:176038530-176038550 3 2.07e-05 GA CAGCACCA CACCAGGGCT chr18:47425014-47425034 10 2.07e-05 aaaacaagt cagcacca cgg chr14:82542106-82542126 12 2.07e-05 GCACCTTGGA CAGCACCA G chr12:113503210-11350323 12 2.07e-05 GTACCTTGGA CAGCACCA T chr9:34494126-34494146 12 5.97e-05 GGCTGGTTTT CAGCACCT C chr3:2345433-2345453 6 5.97e-05 GAGGA CAGCTCCA AGTTTAT chr10:87963451-87963471 6 1.26e-04 CTGGA CAGCGCCA TGAGCAC chr15:51973702-51973722 8 1.26e-04 GGAACTT CAGCACCC ACAGG chr9:119760731-119760751 3 1.26e-04 GT CAGCACCC TGAGAACTCT chr11:117467995-11746801 8 1.26e-04 CCGGGGA CAGCGCCA GAACG chr10:50815162-50815182 12 1.26e-04 GGGCCGGGGC CAGCACCC T chr7:32467491-32467511 10 1.44e-04 CACCGGGGA CAGCTCCT GCC chr1:44434188-44434208 12 1.44e-04 GCACCAGGGA CAGCTCCT G chr3:178402852-178402872 6 1.44e-04 TTGGA CAGCTCCT CTGGGGA chr6:127837397-127837417 11 2.06e-04 ACAGGCTGGA CAGCTCCC GG chr2:137340384-137340404 6 2.06e-04 gtgga cagctccC AGTAACA chr15:48483234-48483254 5 2.06e-04 CGGA CAGCGCCT AGGCGCCT chr14:93389878-93389898 4 2.06e-04 GGA CAGCGCCT CCGCCTCCC chr19:45999752-45999772 2 2.06e-04 A CAGCTCCC CGCGCGCGTC chr17:27333050-27333070 5 2.06e-04 CGGC CAGCGCCT GGCGACGG chr16:10989384-10989404 11 2.06e-04 GCACCACGGA CAGCTCCC AC chr5:139188343-139188363 9 2.59e-04 ACCCTGGA CAGCGCCC CACG chr9:134989672-134989692 7 2.59e-04 CATGGA CAGCGCCC AGCAGA chr15:73639254-73639274 4 2.59e-04 GGA CAGCGCCC AGCACACCT chr1:38230130-38230150 13 2.95e-04 GCACTGCGGA CAGTTCCA chr5:132901861-132901881 13 3.68e-04 GCACCATGGA CAGCAGCA chr14:90961802-90961822 5 4.00e-04 TGGA GAGCACCA CAGTGATC chr1:50774693-50774713 12 4.49e-04 GAGGCTGTTT CAGAACCA T chr2:42018855-42018875 11 4.49e-04 GCACCATGGA CAGCATCT CT chr22:47184518-47184538 6 4.99e-04 cagga cagtgcct gcctcgt chr1:210900135-210900155 6 4.99e-04 ATGGA CAGTTCCC CGGCGGG chr3:42341667-42341687 9 4.99e-04 GTGGAGGA CAGTTCCC TGCT chr1:107678267-107678287 11 4.99e-04 GCACCAAGGA CAGTTCCC AG chr1:38261216-38261236 4 6.12e-04 CTT CAGCACCG CGGGCGTGG chr14:78996581-78996601 10 6.12e-04 GGAGATTTT CAGCACCG TGG chr19:3244200-3244220 5 6.12e-04 GGGA CAGCGTCA GGGCGGGC chr12:3601561-3601581 9 8.11e-04 CGCCCCTG CAGCAGCC GAGC chr12:108862269-10886228 13 9.24e-04 GAACTAACTT CAGGACCA chr12:67587673-67587693 12 9.24e-04 GGACCCTGGA CAGCTCTA C chr3:54222375-54222395 10 1.10e-03 CACCAAGGA CAGCGACA TGC chr2:59061738-59061758 2 1.10e-03 A CAGCGACA CTCAAATTCC chr6:110299901-110299921 5 1.10e-03 CGGA CAGCGTCT CTGCTGCC chr9:119568544-119568564 10 1.34e-03 GACCATGGA CAGCACAA GGC chr22:21364067-21364087 7 1.45e-03 CATGGA GAGCTCCC TGCACA chr3:38847457-38847477 11 1.45e-03 AATAGCTAGT GAGCGCCT AG chr11:119645077-11964509 8 1.59e-03 CCCTGGA CAGAGCCT AAGAA chr16:750791-750811 7 1.59e-03 CATGGA CAGCGGCC GCCCCA chr13:53424932-53424952 7 1.59e-03 GGTGGA CAGCGGCC TCAGCG chrX:18165295-18165315 10 1.75e-03 GCAGTTATT CAGGACCC TGG chr19:36319758-36319778 12 1.75e-03 GCACCATGGA CAGCGCTT T chr1:33352328-33352348 7 1.75e-03 GCCCTG GAGCGCCC CCTCCA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCDCCH MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:219910856-219910876 2.1e-05 9_[+3]_3 chr3:187387621-187387641 2.1e-05 12_[+3] chr11:1423010-1423030 2.1e-05 4_[+3]_8 chr12:119499197-11949921 2.1e-05 10_[+3]_2 chr5:176038530-176038550 2.1e-05 2_[+3]_10 chr18:47425014-47425034 2.1e-05 9_[+3]_3 chr14:82542106-82542126 2.1e-05 11_[+3]_1 chr12:113503210-11350323 2.1e-05 11_[+3]_1 chr9:34494126-34494146 6e-05 11_[+3]_1 chr3:2345433-2345453 6e-05 5_[+3]_7 chr10:87963451-87963471 0.00013 5_[+3]_7 chr15:51973702-51973722 0.00013 7_[+3]_5 chr9:119760731-119760751 0.00013 2_[+3]_10 chr11:117467995-11746801 0.00013 7_[+3]_5 chr10:50815162-50815182 0.00013 11_[+3]_1 chr7:32467491-32467511 0.00014 9_[+3]_3 chr1:44434188-44434208 0.00014 11_[+3]_1 chr3:178402852-178402872 0.00014 5_[+3]_7 chr6:127837397-127837417 0.00021 10_[+3]_2 chr2:137340384-137340404 0.00021 5_[+3]_7 chr15:48483234-48483254 0.00021 4_[+3]_8 chr14:93389878-93389898 0.00021 3_[+3]_9 chr19:45999752-45999772 0.00021 1_[+3]_11 chr17:27333050-27333070 0.00021 4_[+3]_8 chr16:10989384-10989404 0.00021 10_[+3]_2 chr5:139188343-139188363 0.00026 8_[+3]_4 chr9:134989672-134989692 0.00026 6_[+3]_6 chr15:73639254-73639274 0.00026 3_[+3]_9 chr1:38230130-38230150 0.00029 12_[+3] chr5:132901861-132901881 0.00037 12_[+3] chr14:90961802-90961822 0.0004 4_[+3]_8 chr1:50774693-50774713 0.00045 11_[+3]_1 chr2:42018855-42018875 0.00045 10_[+3]_2 chr22:47184518-47184538 0.0005 5_[+3]_7 chr1:210900135-210900155 0.0005 5_[+3]_7 chr3:42341667-42341687 0.0005 8_[+3]_4 chr1:107678267-107678287 0.0005 10_[+3]_2 chr1:38261216-38261236 0.00061 3_[+3]_9 chr14:78996581-78996601 0.00061 9_[+3]_3 chr19:3244200-3244220 0.00061 4_[+3]_8 chr12:3601561-3601581 0.00081 8_[+3]_4 chr12:108862269-10886228 0.00092 12_[+3] chr12:67587673-67587693 0.00092 11_[+3]_1 chr3:54222375-54222395 0.0011 9_[+3]_3 chr2:59061738-59061758 0.0011 1_[+3]_11 chr6:110299901-110299921 0.0011 4_[+3]_8 chr9:119568544-119568564 0.0013 9_[+3]_3 chr22:21364067-21364087 0.0015 6_[+3]_6 chr3:38847457-38847477 0.0015 10_[+3]_2 chr11:119645077-11964509 0.0016 7_[+3]_5 chr16:750791-750811 0.0016 6_[+3]_6 chr13:53424932-53424952 0.0016 6_[+3]_6 chrX:18165295-18165315 0.0017 9_[+3]_3 chr19:36319758-36319778 0.0017 11_[+3]_1 chr1:33352328-33352348 0.0017 6_[+3]_6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCDCCH MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CAGCDCCH width=8 seqs=55 chr2:219910856-219910876 ( 10) CAGCACCA 1 chr3:187387621-187387641 ( 13) CAGCACCA 1 chr11:1423010-1423030 ( 5) CAGCACCA 1 chr12:119499197-11949921 ( 11) CAGCACCA 1 chr5:176038530-176038550 ( 3) CAGCACCA 1 chr18:47425014-47425034 ( 10) CAGCACCA 1 chr14:82542106-82542126 ( 12) CAGCACCA 1 chr12:113503210-11350323 ( 12) CAGCACCA 1 chr9:34494126-34494146 ( 12) CAGCACCT 1 chr3:2345433-2345453 ( 6) CAGCTCCA 1 chr10:87963451-87963471 ( 6) CAGCGCCA 1 chr15:51973702-51973722 ( 8) CAGCACCC 1 chr9:119760731-119760751 ( 3) CAGCACCC 1 chr11:117467995-11746801 ( 8) CAGCGCCA 1 chr10:50815162-50815182 ( 12) CAGCACCC 1 chr7:32467491-32467511 ( 10) CAGCTCCT 1 chr1:44434188-44434208 ( 12) CAGCTCCT 1 chr3:178402852-178402872 ( 6) CAGCTCCT 1 chr6:127837397-127837417 ( 11) CAGCTCCC 1 chr2:137340384-137340404 ( 6) CAGCTCCC 1 chr15:48483234-48483254 ( 5) CAGCGCCT 1 chr14:93389878-93389898 ( 4) CAGCGCCT 1 chr19:45999752-45999772 ( 2) CAGCTCCC 1 chr17:27333050-27333070 ( 5) CAGCGCCT 1 chr16:10989384-10989404 ( 11) CAGCTCCC 1 chr5:139188343-139188363 ( 9) CAGCGCCC 1 chr9:134989672-134989692 ( 7) CAGCGCCC 1 chr15:73639254-73639274 ( 4) CAGCGCCC 1 chr1:38230130-38230150 ( 13) CAGTTCCA 1 chr5:132901861-132901881 ( 13) CAGCAGCA 1 chr14:90961802-90961822 ( 5) GAGCACCA 1 chr1:50774693-50774713 ( 12) CAGAACCA 1 chr2:42018855-42018875 ( 11) CAGCATCT 1 chr22:47184518-47184538 ( 6) CAGTGCCT 1 chr1:210900135-210900155 ( 6) CAGTTCCC 1 chr3:42341667-42341687 ( 9) CAGTTCCC 1 chr1:107678267-107678287 ( 11) CAGTTCCC 1 chr1:38261216-38261236 ( 4) CAGCACCG 1 chr14:78996581-78996601 ( 10) CAGCACCG 1 chr19:3244200-3244220 ( 5) CAGCGTCA 1 chr12:3601561-3601581 ( 9) CAGCAGCC 1 chr12:108862269-10886228 ( 13) CAGGACCA 1 chr12:67587673-67587693 ( 12) CAGCTCTA 1 chr3:54222375-54222395 ( 10) CAGCGACA 1 chr2:59061738-59061758 ( 2) CAGCGACA 1 chr6:110299901-110299921 ( 5) CAGCGTCT 1 chr9:119568544-119568564 ( 10) CAGCACAA 1 chr22:21364067-21364087 ( 7) GAGCTCCC 1 chr3:38847457-38847477 ( 11) GAGCGCCT 1 chr11:119645077-11964509 ( 8) CAGAGCCT 1 chr16:750791-750811 ( 7) CAGCGGCC 1 chr13:53424932-53424952 ( 7) CAGCGGCC 1 chrX:18165295-18165315 ( 10) CAGGACCC 1 chr19:36319758-36319778 ( 12) CAGCGCTT 1 chr1:33352328-33352348 ( 7) GAGCGCCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCDCCH MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 5.6795 E= 3.0e-021 -1243 159 -211 -1243 236 -1243 -1243 -1243 -1243 -1243 167 -1243 -242 145 -311 -101 104 -1243 14 47 -242 145 -211 -175 -342 162 -1243 -233 97 17 -311 37 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCDCCH MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 55 E= 3.0e-021 0.000000 0.927273 0.072727 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.036364 0.836364 0.036364 0.090909 0.400000 0.000000 0.345455 0.254545 0.036364 0.836364 0.072727 0.054545 0.018182 0.945455 0.000000 0.036364 0.381818 0.345455 0.036364 0.236364 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAGCDCCH MEME-3 regular expression -------------------------------------------------------------------------------- CAGC[AGT]CC[ACT] -------------------------------------------------------------------------------- Time 8.39 secs. ******************************************************************************** ******************************************************************************** MOTIF GTGCTGAA MEME-4 width = 8 sites = 19 llr = 188 E-value = 8.6e-019 ******************************************************************************** -------------------------------------------------------------------------------- Motif GTGCTGAA MEME-4 Description -------------------------------------------------------------------------------- Simplified A ::::::98 pos.-specific C ::1a:::1 probability G a:9::a11 matrix T :a::a::1 bits 2.4 * * 2.2 * * 2.0 * * 1.7 ** **** Relative 1.5 ******* Entropy 1.2 ******** (14.3 bits) 1.0 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel GTGCTGAA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GTGCTGAA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr20:45152795-45152815 11 1.22e-05 TTCACCCCTG GTGCTGAA TT chr1:7676600-7676620 2 1.22e-05 A GTGCTGAA AAGGAAGCCG chr5:1409624-1409644 11 1.22e-05 AGCTGTCCAG GTGCTGAA GT chr15:89962788-89962808 11 1.22e-05 CCTCCCAGTG GTGCTGAA AC chr17:6173026-6173046 13 1.22e-05 GCTGGCCGTG GTGCTGAA chr3:179754578-179754598 11 1.22e-05 TCCGCTCGGG GTGCTGAA AG chr5:14628657-14628677 13 1.22e-05 GCTGTCTGTG GTGCTGAA chr6:35773080-35773100 5 1.22e-05 CGCG GTGCTGAA ACGGCGCC chr19:52056627-52056647 5 1.22e-05 CCTG GTGCTGAA GCAGGACT chr22:39220697-39220717 5 1.22e-05 CAGG GTGCTGAA TTCCTTCT chr2:219827747-219827767 5 1.22e-05 CGTG GTGCTGAA TGGCGCGC chr5:75400067-75400087 10 1.22e-05 CTGGCCAAA GTGCTGAA ATG chr1:31655319-31655339 5 1.22e-05 CAGG GTGCTGAA GGCGCAGG chr6:37493728-37493748 13 3.20e-05 CACACCTCGG GTGCTGAG chr6:90605211-90605231 4 5.17e-05 GCA GTGCTGGA AATCAGCAC chr1:47201574-47201594 5 6.32e-05 CATG GTGCTGAT GTAAATCC chr6:146349536-146349556 6 7.51e-05 CCAGG GTCCTGAA GGCGGCA chr1:34966235-34966255 6 9.43e-05 CCACG GTGCTGAC ACCCGCC chr19:13552867-13552887 2 1.26e-04 T GTGCTGGG AGCTGTCCAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GTGCTGAA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr20:45152795-45152815 1.2e-05 10_[+4]_2 chr1:7676600-7676620 1.2e-05 1_[+4]_11 chr5:1409624-1409644 1.2e-05 10_[+4]_2 chr15:89962788-89962808 1.2e-05 10_[+4]_2 chr17:6173026-6173046 1.2e-05 12_[+4] chr3:179754578-179754598 1.2e-05 10_[+4]_2 chr5:14628657-14628677 1.2e-05 12_[+4] chr6:35773080-35773100 1.2e-05 4_[+4]_8 chr19:52056627-52056647 1.2e-05 4_[+4]_8 chr22:39220697-39220717 1.2e-05 4_[+4]_8 chr2:219827747-219827767 1.2e-05 4_[+4]_8 chr5:75400067-75400087 1.2e-05 9_[+4]_3 chr1:31655319-31655339 1.2e-05 4_[+4]_8 chr6:37493728-37493748 3.2e-05 12_[+4] chr6:90605211-90605231 5.2e-05 3_[+4]_9 chr1:47201574-47201594 6.3e-05 4_[+4]_8 chr6:146349536-146349556 7.5e-05 5_[+4]_7 chr1:34966235-34966255 9.4e-05 5_[+4]_7 chr19:13552867-13552887 0.00013 1_[+4]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GTGCTGAA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GTGCTGAA width=8 seqs=19 chr20:45152795-45152815 ( 11) GTGCTGAA 1 chr1:7676600-7676620 ( 2) GTGCTGAA 1 chr5:1409624-1409644 ( 11) GTGCTGAA 1 chr15:89962788-89962808 ( 11) GTGCTGAA 1 chr17:6173026-6173046 ( 13) GTGCTGAA 1 chr3:179754578-179754598 ( 11) GTGCTGAA 1 chr5:14628657-14628677 ( 13) GTGCTGAA 1 chr6:35773080-35773100 ( 5) GTGCTGAA 1 chr19:52056627-52056647 ( 5) GTGCTGAA 1 chr22:39220697-39220717 ( 5) GTGCTGAA 1 chr2:219827747-219827767 ( 5) GTGCTGAA 1 chr5:75400067-75400087 ( 10) GTGCTGAA 1 chr1:31655319-31655339 ( 5) GTGCTGAA 1 chr6:37493728-37493748 ( 13) GTGCTGAG 1 chr6:90605211-90605231 ( 4) GTGCTGGA 1 chr1:47201574-47201594 ( 5) GTGCTGAT 1 chr6:146349536-146349556 ( 6) GTCCTGAA 1 chr1:34966235-34966255 ( 6) GTGCTGAC 1 chr19:13552867-13552887 ( 2) GTGCTGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GTGCTGAA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.31119 E= 8.6e-019 -1089 -1089 167 -1089 -1089 -1089 -1089 245 -1089 -254 159 -1089 -1089 170 -1089 -1089 -1089 -1089 -1089 245 -1089 -1089 167 -1089 220 -1089 -158 -1089 202 -254 -158 -180 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GTGCTGAA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 19 E= 8.6e-019 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.052632 0.947368 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.894737 0.000000 0.105263 0.000000 0.789474 0.052632 0.105263 0.052632 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GTGCTGAA MEME-4 regular expression -------------------------------------------------------------------------------- GTGCTGAA -------------------------------------------------------------------------------- Time 10.98 secs. ******************************************************************************** ******************************************************************************** MOTIF TGKTTCAG MEME-5 width = 8 sites = 7 llr = 70 E-value = 2.1e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGKTTCAG MEME-5 Description -------------------------------------------------------------------------------- Simplified A 1:1:::a: pos.-specific C :::::9:: probability G :a3::::a matrix T 9:6aa1:: bits 2.4 ** * 2.2 ** * 2.0 * ** * 1.7 ** ** ** Relative 1.5 ** ** ** Entropy 1.2 ** ***** (14.5 bits) 1.0 ** ***** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TGTTTCAG consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGKTTCAG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr5:174749104-174749124 9 6.66e-06 GTTGTGTC TGTTTCAG CACC chr8:142970867-142970887 2 6.66e-06 c tgtttcag caccagggac chr5:161495678-161495698 1 1.81e-05 . TGGTTCAG CACCAGGGAC chr1:7135567-7135587 1 1.81e-05 . TGGTTCAG CACCAAGGAC chr7:8157003-8157023 3 2.21e-05 CC TGTTTTAG GGACAGCAAA chr16:9025883-9025903 2 2.92e-05 C TGATTCAG CACCACGGAC chr19:55028867-55028887 2 3.63e-05 T AGTTTCAG CACCATGGCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGKTTCAG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr5:174749104-174749124 6.7e-06 8_[+5]_4 chr8:142970867-142970887 6.7e-06 1_[+5]_11 chr5:161495678-161495698 1.8e-05 [+5]_12 chr1:7135567-7135587 1.8e-05 [+5]_12 chr7:8157003-8157023 2.2e-05 2_[+5]_10 chr16:9025883-9025903 2.9e-05 1_[+5]_11 chr19:55028867-55028887 3.6e-05 1_[+5]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGKTTCAG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGKTTCAG width=8 seqs=7 chr5:174749104-174749124 ( 9) TGTTTCAG 1 chr8:142970867-142970887 ( 2) TGTTTCAG 1 chr5:161495678-161495698 ( 1) TGGTTCAG 1 chr1:7135567-7135587 ( 1) TGGTTCAG 1 chr7:8157003-8157023 ( 3) TGTTTTAG 1 chr16:9025883-9025903 ( 2) TGATTCAG 1 chr19:55028867-55028887 ( 2) AGTTTCAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGKTTCAG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.69928 E= 2.1e+001 -45 -945 -945 222 -945 -945 167 -945 -45 -945 -14 164 -945 -945 -945 244 -945 -945 -945 244 -945 148 -945 -36 236 -945 -945 -945 -945 -945 167 -945 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGKTTCAG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 7 E= 2.1e+001 0.142857 0.000000 0.000000 0.857143 0.000000 0.000000 1.000000 0.000000 0.142857 0.000000 0.285714 0.571429 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.857143 0.000000 0.142857 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGKTTCAG MEME-5 regular expression -------------------------------------------------------------------------------- TG[TG]TTCAG -------------------------------------------------------------------------------- Time 13.37 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:38230130-38230150 2.33e-02 20 chr3:38847457-38847477 3.07e-01 20 chr11:74925588-74925608 2.75e-04 6_[+3(5.97e-05)]_6 chr6:88146311-88146331 9.97e-04 6_[+1(1.27e-05)]_6 chr1:11919528-11919548 1.85e-06 1_[+2(6.59e-05)]_3_[+4(6.32e-05)] chr19:55028867-55028887 7.87e-06 6_[+3(2.07e-05)]_6 chr1:107678267-107678287 2.48e-03 2_[+1(6.12e-05)]_10 chr19:5404240-5404260 2.00e-03 20 chr1:31655319-31655339 1.24e-02 4_[+4(1.22e-05)]_8 chr10:50815162-50815182 3.48e-02 20 chr7:126747967-126747987 1.77e-05 6_[+2(1.87e-05)]_6 chr20:1986651-1986671 3.96e-02 20 chr10:26656934-26656954 5.27e-01 20 chr5:133877584-133877604 1.34e-02 20 chr16:9025883-9025903 2.43e-06 6_[+3(2.07e-05)]_6 chr11:116476443-11647646 5.45e-01 20 chr13:53424932-53424952 8.18e-02 20 chr8:67089868-67089888 4.65e-02 11_[+2(6.59e-05)]_1 chr14:77675216-77675236 5.55e-06 3_[+2(3.63e-05)]_9 chr20:47139878-47139898 1.72e-04 8_[+2(1.87e-05)]_4 chr16:89992899-89992919 3.02e-01 20 chr22:39941959-39941979 1.66e-04 6_[+3(2.07e-05)]_6 chr10:125374600-12537462 1.34e-05 9_[+1(1.27e-05)]_3 chr8:56015576-56015596 1.66e-01 20 chr5:75400067-75400087 1.95e-02 9_[+4(1.22e-05)]_3 chr1:47201574-47201594 2.46e-02 4_[+4(6.32e-05)]_8 chr2:220173037-220173057 1.70e-03 5_[+2(6.59e-05)]_7 chr12:113503210-11350323 6.19e-04 11_[+3(2.07e-05)]_1 chr9:140779173-140779193 7.55e-01 20 chr2:73518398-73518418 1.89e-02 20 chr2:217237080-217237100 7.62e-01 20 chr1:33352328-33352348 2.93e-02 20 chr17:56197755-56197775 7.55e-04 7_[+1(4.77e-05)]_5 chr16:2765628-2765648 3.50e-02 12_[+2(6.59e-05)] chr20:37314683-37314703 2.49e-04 6_[+4(9.43e-05)]_6 chr2:47798602-47798622 2.60e-02 20 chr7:100701852-100701872 6.79e-06 9_[+1(1.27e-05)]_3 chr16:24869951-24869971 8.65e-06 10_[+1(1.27e-05)]_2 chr10:73555160-73555180 1.83e-04 9_[+1(1.27e-05)]_3 chr14:82542106-82542126 6.19e-04 11_[+3(2.07e-05)]_1 chr22:31198908-31198928 3.66e-03 6_[+2(6.59e-05)]_6 chr10:86051351-86051371 5.15e-01 20 chr15:73639254-73639274 1.38e-01 20 chr15:83332068-83332088 1.09e-04 7_[+1(1.27e-05)]_5 chr12:101220296-10122031 2.08e-05 5_[+2(3.63e-05)]_7 chr20:5892344-5892364 1.23e-02 20 chr10:16654438-16654458 1.85e-06 6_[+1(4.77e-05)]_6 chr9:139941190-139941210 2.29e-04 9_[+2(1.87e-05)]_3 chr19:36319758-36319778 2.24e-03 3_[+1(1.27e-05)]_9 chr3:42341667-42341687 2.36e-02 20 chr2:219827747-219827767 5.58e-03 4_[+4(1.22e-05)]_8 chr22:39220697-39220717 1.13e-02 4_[+4(1.22e-05)]_8 chr1:32189541-32189561 2.11e-03 20 chr6:89248008-89248028 3.82e-02 12_[+2(6.59e-05)] chr19:3244200-3244220 7.54e-02 20 chr20:31797728-31797748 1.53e-02 20 chr14:77600272-77600292 5.18e-02 20 chr2:44243613-44243633 1.92e-02 1_[+1(1.27e-05)]_11 chr17:29721784-29721804 5.58e-04 7_[+1(1.27e-05)]_5 chr22:44263893-44263913 2.40e-03 3_[+2(6.59e-05)]_9 chr18:47425014-47425034 4.08e-02 9_[+3(2.07e-05)]_3 chr7:31154762-31154782 3.44e-03 [+1(1.27e-05)]_12 chr12:108608449-10860846 7.96e-04 11_[+1(4.77e-05)]_1 chr2:73110669-73110689 2.07e-01 20 chr8:54790569-54790589 8.86e-01 20 chr15:91730670-91730690 4.31e-02 20 chr8:142970867-142970887 1.17e-06 1_[+5(6.66e-06)]_11 chr19:52056627-52056647 3.63e-03 4_[+4(1.22e-05)]_8 chr20:43408978-43408998 1.74e-04 20 chr11:117467995-11746801 1.20e-01 20 chr5:95770034-95770054 3.85e-01 20 chr12:53135348-53135368 1.21e-02 1_[+1(6.12e-05)]_11 chr5:176038530-176038550 7.15e-03 2_[+3(2.07e-05)]_10 chr9:119760731-119760751 5.76e-02 20 chr16:10989384-10989404 2.49e-03 20 chr3:2345433-2345453 9.29e-03 5_[+3(5.97e-05)]_7 chr15:70268901-70268921 6.52e-04 10_[+1(4.77e-05)]_2 chr14:90961802-90961822 1.00e-01 20 chr14:78996581-78996601 2.04e-02 20 chr9:134674743-134674763 6.01e-02 20 chr20:37321205-37321225 3.26e-06 1_[+2(6.59e-05)]_3_[+4(9.43e-05)] chr6:88930434-88930454 3.57e-01 20 chr2:42018855-42018875 9.54e-04 2_[+1(1.27e-05)]_10 chr2:16727599-16727619 3.58e-05 7_[+4(1.22e-05)]_5 chr15:51973702-51973722 4.42e-02 20 chr5:33936198-33936218 8.37e-01 20 chr6:12752119-12752139 1.14e-03 2_[+2(1.87e-05)]_10 chr8:41753572-41753592 1.10e-03 8_[+2(3.63e-05)]_4 chr16:89104144-89104164 5.22e-02 20 chr3:42743094-42743114 4.29e-01 20 chr9:36748501-36748521 1.09e-04 4_[+1(1.27e-05)]_8 chr6:35773080-35773100 1.33e-02 4_[+4(1.22e-05)]_8 chr6:24127171-24127191 2.22e-01 20 chr3:10795857-10795877 2.18e-01 20 chr12:100933173-10093319 2.41e-04 10_[+4(5.17e-05)]_2 chr6:110299901-110299921 3.30e-02 20 chr10:105038749-10503876 9.03e-01 20 chr10:105025667-10502568 6.42e-07 1_[+2(1.87e-05)]_11 chr1:169565184-169565204 8.39e-04 8_[+4(7.51e-05)]_4 chr16:750791-750811 2.54e-01 20 chr5:14628657-14628677 3.96e-06 12_[+4(1.22e-05)] chr1:11610909-11610929 5.79e-01 20 chr8:129157329-129157349 7.72e-01 20 chr3:139516767-139516787 1.96e-05 3_[+2(6.59e-05)]_9 chr5:141123134-141123154 8.75e-04 4_[+1(4.77e-05)]_8 chr14:79329687-79329707 2.54e-04 6_[+4(1.22e-05)]_6 chr3:179754578-179754598 2.02e-02 10_[+4(1.22e-05)]_2 chr19:7627881-7627901 1.09e-04 5_[+1(1.27e-05)]_7 chr9:134989672-134989692 1.69e-01 20 chr12:119499197-11949921 1.82e-04 10_[+3(2.07e-05)]_2 chr3:137916131-137916151 6.52e-03 5_[+1(1.27e-05)]_7 chr17:27333050-27333070 1.25e-01 20 chr20:44669707-44669727 1.48e-03 7_[+2(6.59e-05)]_5 chr5:141114578-141114598 1.01e-04 20 chr15:89905082-89905102 3.20e-01 20 chr1:34966235-34966255 3.26e-02 5_[+4(9.43e-05)]_7 chr7:30711660-30711680 5.95e-01 20 chr19:45999752-45999772 4.05e-02 20 chr7:150681156-150681176 5.12e-04 20 chr6:101844616-101844636 1.76e-04 2_[+2(6.59e-05)]_10 chr4:6364829-6364849 1.09e-04 8_[+1(1.27e-05)]_4 chr1:210111113-210111133 6.61e-02 4_[+1(6.12e-05)]_8 chr1:155248169-155248189 4.75e-02 8_[+2(6.59e-05)]_4 chr15:83378287-83378307 1.74e-01 20 chr12:67587673-67587693 9.81e-04 20 chr1:20003078-20003098 7.30e-05 5_[+1(1.27e-05)]_7 chr1:37389990-37390010 7.79e-03 12_[+2(8.41e-05)] chr22:37040474-37040494 1.11e-04 7_[+4(1.22e-05)]_5 chr5:132901861-132901881 1.09e-04 4_[+1(1.27e-05)]_8 chr8:65292631-65292651 1.85e-02 10_[+2(6.59e-05)]_2 chr15:66297174-66297194 2.62e-03 9_[+2(3.63e-05)]_3 chr6:39105220-39105240 2.32e-04 6_[+2(8.41e-05)]_6 chr19:4173197-4173217 7.75e-04 7_[+3(5.97e-05)]_5 chr15:74557566-74557586 4.39e-07 1_[+2(3.63e-05)]_3_[+4(1.22e-05)] chr13:84456235-84456255 3.82e-04 6_[+2(3.63e-05)]_6 chr19:36466709-36466729 8.05e-04 7_[+1(1.27e-05)]_5 chr12:113229372-11322939 3.63e-01 20 chr5:139188343-139188363 3.57e-03 20 chr19:42644481-42644501 3.82e-03 4_[+2(1.87e-05)]_8 chr14:93389878-93389898 2.06e-01 20 chr6:146349536-146349556 2.07e-02 5_[+4(7.51e-05)]_7 chr16:88627321-88627341 1.29e-02 3_[+2(3.63e-05)]_9 chr1:110698725-110698745 1.07e-01 20 chr11:123524783-12352480 9.20e-01 20 chr7:104192739-104192759 1.17e-05 9_[+1(1.27e-05)]_3 chr6:90605211-90605231 1.01e-02 3_[+4(5.17e-05)]_9 chr16:22652566-22652586 2.19e-01 20 chr11:1423010-1423030 5.15e-03 4_[+3(2.07e-05)]_8 chr17:42385974-42385994 6.60e-03 3_[+3(5.97e-05)]_9 chr12:108862269-10886228 8.20e-02 20 chr1:175694982-175695002 3.49e-03 3_[+3(5.97e-05)]_9 chr1:38261216-38261236 1.09e-01 20 chr1:7135567-7135587 4.11e-07 [+5(1.81e-05)]_12 chr2:227675936-227675956 4.15e-02 20 chr20:37309340-37309360 3.47e-03 9_[+2(1.87e-05)]_3 chr1:23999753-23999773 2.38e-03 20 chr11:22359301-22359321 1.05e-04 7_[+4(1.22e-05)]_5 chr22:30112914-30112934 5.03e-04 6_[+2(8.41e-05)]_6 chr10:88066599-88066619 5.33e-03 11_[+2(6.59e-05)]_1 chr1:210900135-210900155 2.77e-02 20 chr15:48483234-48483254 1.08e-01 20 chr20:41816578-41816598 8.61e-01 20 chr17:64825832-64825852 1.97e-04 1_[+2(1.87e-05)]_11 chr1:37486445-37486465 3.22e-01 20 chr11:119645077-11964509 1.84e-01 20 chr12:3601561-3601581 1.24e-01 20 chr17:6173026-6173046 2.87e-05 12_[+4(1.22e-05)] chr14:78986390-78986410 2.62e-05 6_[+4(1.22e-05)]_6 chr22:21364067-21364087 5.58e-02 20 chr11:116250330-11625035 1.25e-04 4_[+2(3.63e-05)]_8 chr1:204806782-204806802 2.08e-02 10_[+2(6.59e-05)]_2 chr1:38541894-38541914 8.34e-02 20 chr3:178402852-178402872 2.69e-02 20 chr8:62408875-62408895 9.78e-01 20 chr2:59061738-59061758 4.31e-01 20 chr1:18582994-18583014 5.43e-04 6_[+4(6.32e-05)]_6 chr3:9746098-9746118 3.46e-04 9_[+2(3.63e-05)]_3 chr10:87963451-87963471 1.04e-01 20 chr14:78865836-78865856 2.34e-04 10_[+4(5.17e-05)]_2 chr5:174749104-174749124 3.95e-03 8_[+5(6.66e-06)]_4 chr8:62200786-62200806 7.23e-01 20 chr19:40089951-40089971 2.29e-05 3_[+2(3.63e-05)]_9 chr10:122273722-12227374 7.16e-04 10_[+4(1.22e-05)]_2 chr11:57652949-57652969 9.78e-04 5_[+2(3.63e-05)]_7 chr3:187387621-187387641 1.04e-03 12_[+3(2.07e-05)] chr19:55728500-55728520 8.29e-05 3_[+2(6.59e-05)]_9 chr19:13552867-13552887 2.79e-05 9_[+2(1.87e-05)]_3 chr2:171670863-171670883 9.88e-03 4_[+2(6.59e-05)]_8 chr16:9930168-9930188 1.01e-05 7_[+1(4.77e-05)]_5 chr2:137340384-137340404 3.95e-02 20 chr10:97151911-97151931 1.28e-04 7_[+3(2.07e-05)]_5 chr5:16179057-16179077 2.34e-02 11_[+2(6.59e-05)]_1 chr12:77527527-77527547 6.34e-01 20 chr1:50774693-50774713 1.21e-04 6_[+5(6.66e-06)]_6 chr1:48996640-48996660 1.36e-03 5_[+2(3.63e-05)]_7 chr22:26655672-26655692 1.79e-03 9_[+2(3.63e-05)]_3 chr9:122133302-122133322 5.70e-01 20 chrX:12567062-12567082 9.36e-04 4_[+3(5.97e-05)]_8 chr10:104121647-10412166 7.12e-03 11_[+2(3.63e-05)]_1 chr11:126431368-12643138 6.91e-04 2_[+3(2.07e-05)]_10 chr22:47184518-47184538 9.90e-02 20 chr1:37721192-37721212 8.75e-02 20 chr15:70265652-70265672 3.15e-01 20 chr16:24267369-24267389 7.50e-01 20 chr4:6227292-6227312 1.58e-03 9_[+4(1.22e-05)]_3 chr18:55021283-55021303 7.21e-01 20 chr20:61713806-61713826 1.25e-03 3_[+3(2.07e-05)]_9 chr2:64524037-64524057 2.21e-03 20 chr2:219910856-219910876 2.95e-02 9_[+3(2.07e-05)]_3 chr9:34984238-34984258 1.07e-02 20 chr1:44434188-44434208 2.19e-03 20 chr17:45863251-45863271 2.51e-03 8_[+2(6.59e-05)]_4 chr5:161495678-161495698 1.65e-06 [+5(1.81e-05)]_12 chr6:127837397-127837417 1.37e-02 20 chr7:32467491-32467511 4.07e-03 20 chr16:1238890-1238910 1.29e-01 20 chr4:170745057-170745077 1.33e-03 20 chr3:49905373-49905393 1.20e-04 12_[+1(4.77e-05)] chr1:74968277-74968297 5.46e-03 20 chr9:119568544-119568564 2.58e-03 1_[+1(1.27e-05)]_11 chr14:89444308-89444328 4.06e-03 1_[+1(1.27e-05)]_11 chr1:209323651-209323671 2.03e-02 20 chr1:95850311-95850331 1.24e-03 20 chr16:68478155-68478175 6.93e-03 7_[+2(8.41e-05)]_5 chr1:235812371-235812391 7.76e-01 20 chr1:65775597-65775617 8.84e-05 8_[+1(1.27e-05)]_4 chr15:89962788-89962808 2.05e-03 10_[+4(1.22e-05)]_2 chrX:18165295-18165315 1.36e-02 20 chr20:33815022-33815042 5.43e-01 20 chr3:115044595-115044615 1.86e-04 20 chr19:43106162-43106182 1.39e-05 1_[+2(3.63e-05)]_11 chr7:8157003-8157023 3.75e-02 2_[+5(2.21e-05)]_10 chr4:147565172-147565192 2.01e-02 3_[+1(1.27e-05)]_9 chr5:1409624-1409644 3.10e-06 [+2(1.87e-05)]_2_[+4(1.22e-05)]_2 chr3:54222375-54222395 8.06e-03 1_[+1(6.12e-05)]_11 chr2:119924829-119924849 1.37e-03 5_[+2(6.59e-05)]_7 chr5:6328434-6328454 7.04e-02 20 chr2:29516876-29516896 3.62e-03 4_[+2(1.87e-05)]_8 chr1:7676600-7676620 3.03e-02 1_[+4(1.22e-05)]_11 chr11:47294447-47294467 3.72e-02 20 chr6:37493728-37493748 1.36e-02 12_[+4(3.20e-05)] chr19:55948893-55948913 9.45e-05 11_[+4(7.51e-05)]_1 chr19:18344116-18344136 3.10e-03 1_[+2(1.87e-05)]_11 chrX:74151197-74151217 6.70e-04 8_[+1(1.27e-05)]_4 chr8:28514905-28514925 4.65e-01 20 chr20:45152795-45152815 1.07e-03 10_[+4(1.22e-05)]_2 chr9:34494126-34494146 6.55e-04 11_[+3(5.97e-05)]_1 chr17:6207185-6207205 1.20e-02 20 chr20:62793400-62793420 7.43e-03 12_[+2(6.59e-05)] chr16:56048040-56048060 2.39e-04 6_[+3(2.07e-05)]_6 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n10.farnam.hpc.yale.internal ********************************************************************************