******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/RELA.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr4:142231223-142231243 1.0000 20 chr1:200122624-200122644 1.0000 20 chr19:6661950-6661970 1.0000 20 chr2:203037816-203037836 1.0000 20 chrX:13276278-13276298 1.0000 20 chr5:122037770-122037790 1.0000 20 chr1:173387552-173387572 1.0000 20 chr3:57773774-57773794 1.0000 20 chr20:32471112-32471132 1.0000 20 chr10:11667162-11667182 1.0000 20 chr2:65166885-65166905 1.0000 20 chr1:32666957-32666977 1.0000 20 chrX:12969562-12969582 1.0000 20 chr15:31804112-31804132 1.0000 20 chr15:83869167-83869187 1.0000 20 chr3:189285722-189285742 1.0000 20 chr12:32405611-32405631 1.0000 20 chr16:48942302-48942322 1.0000 20 chr4:36327318-36327338 1.0000 20 chr17:38480386-38480406 1.0000 20 chr2:38666188-38666208 1.0000 20 chr12:11983329-11983349 1.0000 20 chr8:81395159-81395179 1.0000 20 chr2:60674013-60674033 1.0000 20 chr12:31451641-31451661 1.0000 20 chr3:55642046-55642066 1.0000 20 chr11:10476732-10476752 1.0000 20 chr6:36723713-36723733 1.0000 20 chr3:46003689-46003709 1.0000 20 chr19:6543955-6543975 1.0000 20 chr14:35625416-35625436 1.0000 20 chr1:75197946-75197966 1.0000 20 chrX:1447013-1447033 1.0000 20 chr15:60874740-60874760 1.0000 20 chr17:29288389-29288409 1.0000 20 chr6:107293055-107293075 1.0000 20 chr21:26882382-26882402 1.0000 20 chr2:192531586-192531606 1.0000 20 chr14:89743004-89743024 1.0000 20 chr16:24986928-24986948 1.0000 20 chr7:37823816-37823836 1.0000 20 chr2:9240694-9240714 1.0000 20 chr3:177096150-177096170 1.0000 20 chr15:41775451-41775471 1.0000 20 chr7:122830380-122830400 1.0000 20 chr5:139419331-139419351 1.0000 20 chr1:175567333-175567353 1.0000 20 chr15:96518631-96518651 1.0000 20 chr5:143569521-143569541 1.0000 20 chr7:50332122-50332142 1.0000 20 chr9:108304357-108304377 1.0000 20 chr16:31276858-31276878 1.0000 20 chr3:29323606-29323626 1.0000 20 chr13:47152879-47152899 1.0000 20 chr2:192798212-192798232 1.0000 20 chr2:145116636-145116656 1.0000 20 chr12:1532320-1532340 1.0000 20 chr1:153235431-153235451 1.0000 20 chr9:136822512-136822532 1.0000 20 chr7:43775565-43775585 1.0000 20 chr4:8536095-8536115 1.0000 20 chr22:18586845-18586865 1.0000 20 chr3:28982150-28982170 1.0000 20 chr3:46335849-46335869 1.0000 20 chr10:122611187-12261120 1.0000 20 chr5:142415859-142415879 1.0000 20 chr10:70813675-70813695 1.0000 20 chr12:4255618-4255638 1.0000 20 chr4:10734115-10734135 1.0000 20 chr4:185274711-185274731 1.0000 20 chr2:55361182-55361202 1.0000 20 chr2:238661696-238661716 1.0000 20 chr8:66858336-66858356 1.0000 20 chr5:40224133-40224153 1.0000 20 chr16:10936952-10936972 1.0000 20 chr8:142416423-142416443 1.0000 20 chr12:31358081-31358101 1.0000 20 chr2:24810007-24810027 1.0000 20 chr2:136814667-136814687 1.0000 20 chr1:236588747-236588767 1.0000 20 chr11:72858889-72858909 1.0000 20 chr6:378277-378297 1.0000 20 chr11:14335868-14335888 1.0000 20 chr17:8888547-8888567 1.0000 20 chr10:90754027-90754047 1.0000 20 chr3:170074182-170074202 1.0000 20 chr13:47242268-47242288 1.0000 20 chr4:38821341-38821361 1.0000 20 chr1:235927478-235927498 1.0000 20 chr6:44703550-44703570 1.0000 20 chr17:25544805-25544825 1.0000 20 chr8:10767747-10767767 1.0000 20 chr15:57833117-57833137 1.0000 20 chr21:16197885-16197905 1.0000 20 chr5:140890931-140890951 1.0000 20 chr6:12370254-12370274 1.0000 20 chr15:99780208-99780228 1.0000 20 chr14:76006655-76006675 1.0000 20 chr17:9292587-9292607 1.0000 20 chr1:203398155-203398175 1.0000 20 chr5:130715557-130715577 1.0000 20 chr7:5740973-5740993 1.0000 20 chr12:11975239-11975259 1.0000 20 chr11:61772112-61772132 1.0000 20 chr5:131856656-131856676 1.0000 20 chr3:119419575-119419595 1.0000 20 chr18:56317518-56317538 1.0000 20 chrX:78179317-78179337 1.0000 20 chr1:42416708-42416728 1.0000 20 chr12:111842452-11184247 1.0000 20 chr8:142117086-142117106 1.0000 20 chr18:57514585-57514605 1.0000 20 chr11:116934036-11693405 1.0000 20 chr19:10330627-10330647 1.0000 20 chr16:23335199-23335219 1.0000 20 chr17:39832752-39832772 1.0000 20 chr8:62007873-62007893 1.0000 20 chr15:57592124-57592144 1.0000 20 chr2:175473359-175473379 1.0000 20 chr15:61191658-61191678 1.0000 20 chr11:117815998-11781601 1.0000 20 chr13:111573747-11157376 1.0000 20 chr8:22932316-22932336 1.0000 20 chrX:46569967-46569987 1.0000 20 chr1:183150104-183150124 1.0000 20 chr11:102216780-10221680 1.0000 20 chr4:103422480-103422500 1.0000 20 chr12:11718800-11718820 1.0000 20 chr11:118314406-11831442 1.0000 20 chr2:242067244-242067264 1.0000 20 chr2:68654540-68654560 1.0000 20 chr12:11933880-11933900 1.0000 20 chr14:35630638-35630658 1.0000 20 chr15:96601837-96601857 1.0000 20 chr9:123683217-123683237 1.0000 20 chr11:10510634-10510654 1.0000 20 chr19:50414757-50414777 1.0000 20 chr9:37378321-37378341 1.0000 20 chr17:27065875-27065895 1.0000 20 chr22:35450239-35450259 1.0000 20 chr7:5622364-5622384 1.0000 20 chr11:94317513-94317533 1.0000 20 chr3:19972960-19972980 1.0000 20 chr4:110926818-110926838 1.0000 20 chr3:15398352-15398372 1.0000 20 chr9:140655634-140655654 1.0000 20 chr18:60818354-60818374 1.0000 20 chr22:21104976-21104996 1.0000 20 chr3:121823776-121823796 1.0000 20 chr17:12334714-12334734 1.0000 20 chr13:71865518-71865538 1.0000 20 chr5:17278249-17278269 1.0000 20 chr3:193460605-193460625 1.0000 20 chr1:37943030-37943050 1.0000 20 chr4:113209756-113209776 1.0000 20 chr17:64981637-64981657 1.0000 20 chr11:8553675-8553695 1.0000 20 chr3:122417262-122417282 1.0000 20 chr6:3209840-3209860 1.0000 20 chr7:20338201-20338221 1.0000 20 chr1:221948699-221948719 1.0000 20 chr22:40988895-40988915 1.0000 20 chr2:197201592-197201612 1.0000 20 chr7:26196132-26196152 1.0000 20 chr2:80752502-80752522 1.0000 20 chr16:75186708-75186728 1.0000 20 chr2:106419296-106419316 1.0000 20 chr3:143551421-143551441 1.0000 20 chr3:131450757-131450777 1.0000 20 chr15:31548123-31548143 1.0000 20 chr8:103567744-103567764 1.0000 20 chr5:132657740-132657760 1.0000 20 chr18:28848258-28848278 1.0000 20 chr1:203350455-203350475 1.0000 20 chr9:71417819-71417839 1.0000 20 chr18:60828446-60828466 1.0000 20 chr6:152481636-152481656 1.0000 20 chr6:89471610-89471630 1.0000 20 chr7:111696595-111696615 1.0000 20 chr15:76352789-76352809 1.0000 20 chr19:50398703-50398723 1.0000 20 chr6:137051985-137052005 1.0000 20 chr2:217087922-217087942 1.0000 20 chr8:126221601-126221621 1.0000 20 chr4:146981197-146981217 1.0000 20 chr9:126518972-126518992 1.0000 20 chr2:145122694-145122714 1.0000 20 chr7:50420128-50420148 1.0000 20 chr12:108961963-10896198 1.0000 20 chr6:150958132-150958152 1.0000 20 chr8:70673310-70673330 1.0000 20 chr8:72751403-72751423 1.0000 20 chr10:92759416-92759436 1.0000 20 chr11:7552407-7552427 1.0000 20 chr8:65669526-65669546 1.0000 20 chr18:56301275-56301295 1.0000 20 chr6:12119499-12119519 1.0000 20 chr7:134873627-134873647 1.0000 20 chr5:18746565-18746585 1.0000 20 chr17:57923777-57923797 1.0000 20 chr16:10915275-10915295 1.0000 20 chr12:90354132-90354152 1.0000 20 chr5:64344280-64344300 1.0000 20 chr2:85166987-85167007 1.0000 20 chr1:156135058-156135078 1.0000 20 chr4:105411410-105411430 1.0000 20 chr12:78140120-78140140 1.0000 20 chr17:27215059-27215079 1.0000 20 chr6:155502833-155502853 1.0000 20 chr10:81091674-81091694 1.0000 20 chr6:43682871-43682891 1.0000 20 chr8:91640262-91640282 1.0000 20 chr6:138194671-138194691 1.0000 20 chr12:121998458-12199847 1.0000 20 chr13:52393513-52393533 1.0000 20 chr6:13274225-13274245 1.0000 20 chr15:68325207-68325227 1.0000 20 chr15:70433185-70433205 1.0000 20 chr6:11825335-11825355 1.0000 20 chr10:61641111-61641131 1.0000 20 chrX:87155451-87155471 1.0000 20 chr18:60826341-60826361 1.0000 20 chr11:117480944-11748096 1.0000 20 chr17:39495306-39495326 1.0000 20 chr2:223288498-223288518 1.0000 20 chr11:103830148-10383016 1.0000 20 chr5:114404693-114404713 1.0000 20 chr3:179601096-179601116 1.0000 20 chr1:9686362-9686382 1.0000 20 chr12:69964732-69964752 1.0000 20 chr9:132695263-132695283 1.0000 20 chr17:27476746-27476766 1.0000 20 chr1:159047205-159047225 1.0000 20 chr9:136285778-136285798 1.0000 20 chr3:148943164-148943184 1.0000 20 chr18:60825108-60825128 1.0000 20 chr19:42970105-42970125 1.0000 20 chr19:40447852-40447872 1.0000 20 chr21:45377579-45377599 1.0000 20 chr12:122900943-12290096 1.0000 20 chr21:45592686-45592706 1.0000 20 chr14:53647533-53647553 1.0000 20 chr10:108691375-10869139 1.0000 20 chr16:69598017-69598037 1.0000 20 chr7:44790713-44790733 1.0000 20 chr8:24245189-24245209 1.0000 20 chr14:94812805-94812825 1.0000 20 chr5:71772777-71772797 1.0000 20 chr8:81987060-81987080 1.0000 20 chr11:60134662-60134682 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_RELA/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/RELA.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.245 C 0.237 G 0.251 T 0.267 Background letter frequencies (from file dataset with add-one prior applied): A 0.245 C 0.237 G 0.251 T 0.267 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF GRAWTTCC MEME-1 width = 8 sites = 71 llr = 479 E-value = 2.8e-046 ******************************************************************************** -------------------------------------------------------------------------------- Motif GRAWTTCC MEME-1 Description -------------------------------------------------------------------------------- Simplified A :48621:: pos.-specific C ::1:12aa probability G a51:2::: matrix T ::1458:: bits 2.1 * * 1.9 * ** 1.7 * ** 1.5 * ** Relative 1.2 * ** Entropy 1.0 * *** (9.7 bits) 0.8 **** *** 0.6 **** *** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GGAATTCC consensus A TA sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GRAWTTCC MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:111696595-111696615 2 1.51e-05 g ggaattcc tcccaaggga chr2:106419296-106419316 3 1.51e-05 CT GGAATTCC CCTTTTTTGT chr7:26196132-26196152 11 1.51e-05 AACTGACTCT GGAATTCC CC chr19:10330627-10330647 10 1.51e-05 TAGAGAAGG GGAATTCC GAT chr4:8536095-8536115 12 1.51e-05 cttggccagg ggaattcc a chr15:41775451-41775471 8 1.51e-05 GTGCTGG GGAATTCC CTCAT chr8:81987060-81987080 11 2.99e-05 CTGAGGTTAG GAAATTCC CT chr16:69598017-69598037 9 4.64e-05 CGTACTGG GGATTTCC TATA chr2:80752502-80752522 3 4.64e-05 CT GGATTTCC CCTTCTGTGT chr3:15398352-15398372 10 4.64e-05 TACCAAAGG GGATTTCC AAG chr6:378277-378297 4 4.64e-05 TGG GGATTTCC CCGAGGCTT chr4:36327318-36327338 5 4.64e-05 AAGG GGATTTCC AAGGTTGC chr12:78140120-78140140 5 7.64e-05 AGTG GGAAATCC CCATCAGA chr19:50414757-50414777 3 7.64e-05 CA GGAAATCC CCTTCCAGCT chr2:68654540-68654560 3 7.64e-05 TT GGAAATCC CCGCTTCTGG chr8:62007873-62007893 8 7.64e-05 AAGGTTT GGAAATCC CCCAT chr5:131856656-131856676 2 7.64e-05 g gaatttcc tcaacctgat chr1:235927478-235927498 3 7.64e-05 tg ggaaatcc ccctcagtct chr5:143569521-143569541 6 7.64e-05 ACTGG GGAAATCC ACCGGAA chr6:107293055-107293075 6 7.64e-05 CTAGA GGAAATCC CCAGTTA chr12:32405611-32405631 10 7.64e-05 ggccagctt ggaaatcc cca chr20:32471112-32471132 10 7.64e-05 gccagggtt ggaaatcc tgg chr19:40447852-40447872 13 1.04e-04 GGCTTCCTGG GGAAGTCC chr1:203398155-203398175 3 1.04e-04 tg gaaaatcc cctcaaactt chr11:7552407-7552427 3 1.33e-04 GG GAAAGTCC CTAAACCACT chr8:70673310-70673330 10 1.33e-04 AGTCAGCAG GAAAGTCC CCA chr17:64981637-64981657 4 1.33e-04 tgg gaaagtcc cggggggct chr13:71865518-71865538 6 1.33e-04 TAGGG GAAAGTCC CCTTAGG chr4:38821341-38821361 7 1.33e-04 CTCTCA GAAAGTCC CTGTGG chr3:55642046-55642066 9 1.33e-04 AAGGCTGG GAAAGTCC CAGC chr4:185274711-185274731 1 1.90e-04 . GAAATCCC CTTACACCCC chr3:177096150-177096170 3 2.35e-04 GG GGATTCCC ATCTTGTCAC chr7:5740973-5740993 10 2.49e-04 CACTTTAGG GGAACTCC ATG chr1:32666957-32666977 13 3.07e-04 TCTATGTGGG GGAAACCC chr22:21104976-21104996 1 3.20e-04 . GAAACTCC CCATTGACAG chr7:5622364-5622384 8 3.20e-04 aaccctg gaaactcc cctct chr17:27215059-27215079 2 3.96e-04 G GGGTTTCC ACTGGAATCT chr3:193460605-193460625 1 3.96e-04 . gggtttcc agtcaacaaa chr17:8888547-8888567 10 3.96e-04 actgcgctg gcaattcc ctg chr11:14335868-14335888 5 3.96e-04 ATGG GGGTTTCC AGCGAGGT chr15:60874740-60874760 10 3.96e-04 TATGTAGGG GGGTTTCC ACT chr16:10915275-10915295 6 4.35e-04 CATGG GAAAACCC CCGTGGA chr15:31548123-31548143 13 4.35e-04 TGTGGAAAGG GGATCTCC chr7:20338201-20338221 3 4.35e-04 TG GAAAACCC CTATTTCTTC chr3:19972960-19972980 12 4.35e-04 AAGTGGCTGG GAAAACCC A chr15:57833117-57833137 10 4.53e-04 GACAATGTG GGTTTTCC CCA chr4:10734115-10734135 3 4.53e-04 GG GGTTTTCC ACTGTCACTG chr7:50332122-50332142 1 4.53e-04 . GGTTTTCC CCAAAGCATT chr10:11667162-11667182 4 4.53e-04 TGG GGTTTTCC CAGGGGGtg chr18:60825108-60825128 7 5.25e-04 ATGAGG GAGTTTCC AATCTG chr3:121823776-121823796 2 5.25e-04 g gaaatacc caggtgtggt chr10:108691375-10869139 1 5.52e-04 . GAAAGCCC CCTGCAGTTT chr17:39832752-39832772 11 5.52e-04 gtgacttttg gaaagccc ct chr2:192798212-192798232 9 5.52e-04 ttggaggg gaaagccc catg chr13:52393513-52393533 7 6.31e-04 TCAGAT GCATTTCC CTTCCT chr6:89471610-89471630 2 6.31e-04 G GGTAATCC CCTAGTGGTC chrX:1447013-1447033 13 6.31e-04 TGAGACGAGG GGCTTTCC chr19:6661950-6661970 9 6.31e-04 gtgtgcct gcatttcc actg chr1:200122624-200122644 12 6.31e-04 GCACAGTAGG GGCTTTCC A chrX:87155451-87155471 2 8.18e-04 G GACTTTCC CCTAAGCCGA chr3:119419575-119419595 7 8.18e-04 TAAGGG GACTTTCC CCTAAG chr16:48942302-48942322 1 8.18e-04 . GAATTACC CTGTAATACC chr11:60134662-60134682 6 8.61e-04 TGGGG GAAATTCA GGGGTTT chr6:3209840-3209860 2 8.61e-04 G GAGAGTCC CCAGAGTGTG chr17:27476746-27476766 10 1.06e-03 GGCCCCCGG GGACTTCC AAA chr5:71772777-71772797 8 1.27e-03 CTGTCTT GGAAATCA CCTCC chr18:28848258-28848278 9 1.45e-03 TTCCTGGG GTATTTCC CAGA chr19:6543955-6543975 12 1.50e-03 CCCATTCTGA GGTTTCCC A chr7:37823816-37823836 1 1.65e-03 . gaatgacc agggactgcc chr8:142117086-142117106 8 2.07e-03 ctgtatg gagatacc cgatt chr1:37943030-37943050 1 2.77e-03 . GAATTCCA GCCTCAAACT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GRAWTTCC MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:111696595-111696615 1.5e-05 1_[+1]_11 chr2:106419296-106419316 1.5e-05 2_[+1]_10 chr7:26196132-26196152 1.5e-05 10_[+1]_2 chr19:10330627-10330647 1.5e-05 9_[+1]_3 chr4:8536095-8536115 1.5e-05 11_[+1]_1 chr15:41775451-41775471 1.5e-05 7_[+1]_5 chr8:81987060-81987080 3e-05 10_[+1]_2 chr16:69598017-69598037 4.6e-05 8_[+1]_4 chr2:80752502-80752522 4.6e-05 2_[+1]_10 chr3:15398352-15398372 4.6e-05 9_[+1]_3 chr6:378277-378297 4.6e-05 3_[+1]_9 chr4:36327318-36327338 4.6e-05 4_[+1]_8 chr12:78140120-78140140 7.6e-05 4_[+1]_8 chr19:50414757-50414777 7.6e-05 2_[+1]_10 chr2:68654540-68654560 7.6e-05 2_[+1]_10 chr8:62007873-62007893 7.6e-05 7_[+1]_5 chr5:131856656-131856676 7.6e-05 1_[+1]_11 chr1:235927478-235927498 7.6e-05 2_[+1]_10 chr5:143569521-143569541 7.6e-05 5_[+1]_7 chr6:107293055-107293075 7.6e-05 5_[+1]_7 chr12:32405611-32405631 7.6e-05 9_[+1]_3 chr20:32471112-32471132 7.6e-05 9_[+1]_3 chr19:40447852-40447872 0.0001 12_[+1] chr1:203398155-203398175 0.0001 2_[+1]_10 chr11:7552407-7552427 0.00013 2_[+1]_10 chr8:70673310-70673330 0.00013 9_[+1]_3 chr17:64981637-64981657 0.00013 3_[+1]_9 chr13:71865518-71865538 0.00013 5_[+1]_7 chr4:38821341-38821361 0.00013 6_[+1]_6 chr3:55642046-55642066 0.00013 8_[+1]_4 chr4:185274711-185274731 0.00019 [+1]_12 chr3:177096150-177096170 0.00024 2_[+1]_10 chr7:5740973-5740993 0.00025 9_[+1]_3 chr1:32666957-32666977 0.00031 12_[+1] chr22:21104976-21104996 0.00032 [+1]_12 chr7:5622364-5622384 0.00032 7_[+1]_5 chr17:27215059-27215079 0.0004 1_[+1]_11 chr3:193460605-193460625 0.0004 [+1]_12 chr17:8888547-8888567 0.0004 9_[+1]_3 chr11:14335868-14335888 0.0004 4_[+1]_8 chr15:60874740-60874760 0.0004 9_[+1]_3 chr16:10915275-10915295 0.00044 5_[+1]_7 chr15:31548123-31548143 0.00044 12_[+1] chr7:20338201-20338221 0.00044 2_[+1]_10 chr3:19972960-19972980 0.00044 11_[+1]_1 chr15:57833117-57833137 0.00045 9_[+1]_3 chr4:10734115-10734135 0.00045 2_[+1]_10 chr7:50332122-50332142 0.00045 [+1]_12 chr10:11667162-11667182 0.00045 3_[+1]_9 chr18:60825108-60825128 0.00053 6_[+1]_6 chr3:121823776-121823796 0.00053 1_[+1]_11 chr10:108691375-10869139 0.00055 [+1]_12 chr17:39832752-39832772 0.00055 10_[+1]_2 chr2:192798212-192798232 0.00055 8_[+1]_4 chr13:52393513-52393533 0.00063 6_[+1]_6 chr6:89471610-89471630 0.00063 1_[+1]_11 chrX:1447013-1447033 0.00063 12_[+1] chr19:6661950-6661970 0.00063 8_[+1]_4 chr1:200122624-200122644 0.00063 11_[+1]_1 chrX:87155451-87155471 0.00082 1_[+1]_11 chr3:119419575-119419595 0.00082 6_[+1]_6 chr16:48942302-48942322 0.00082 [+1]_12 chr11:60134662-60134682 0.00086 5_[+1]_7 chr6:3209840-3209860 0.00086 1_[+1]_11 chr17:27476746-27476766 0.0011 9_[+1]_3 chr5:71772777-71772797 0.0013 7_[+1]_5 chr18:28848258-28848278 0.0015 8_[+1]_4 chr19:6543955-6543975 0.0015 11_[+1]_1 chr7:37823816-37823836 0.0017 [+1]_12 chr8:142117086-142117106 0.0021 7_[+1]_5 chr1:37943030-37943050 0.0028 [+1]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GRAWTTCC MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GRAWTTCC width=8 seqs=71 chr7:111696595-111696615 ( 2) GGAATTCC 1 chr2:106419296-106419316 ( 3) GGAATTCC 1 chr7:26196132-26196152 ( 11) GGAATTCC 1 chr19:10330627-10330647 ( 10) GGAATTCC 1 chr4:8536095-8536115 ( 12) GGAATTCC 1 chr15:41775451-41775471 ( 8) GGAATTCC 1 chr8:81987060-81987080 ( 11) GAAATTCC 1 chr16:69598017-69598037 ( 9) GGATTTCC 1 chr2:80752502-80752522 ( 3) GGATTTCC 1 chr3:15398352-15398372 ( 10) GGATTTCC 1 chr6:378277-378297 ( 4) GGATTTCC 1 chr4:36327318-36327338 ( 5) GGATTTCC 1 chr12:78140120-78140140 ( 5) GGAAATCC 1 chr19:50414757-50414777 ( 3) GGAAATCC 1 chr2:68654540-68654560 ( 3) GGAAATCC 1 chr8:62007873-62007893 ( 8) GGAAATCC 1 chr5:131856656-131856676 ( 2) GAATTTCC 1 chr1:235927478-235927498 ( 3) GGAAATCC 1 chr5:143569521-143569541 ( 6) GGAAATCC 1 chr6:107293055-107293075 ( 6) GGAAATCC 1 chr12:32405611-32405631 ( 10) GGAAATCC 1 chr20:32471112-32471132 ( 10) GGAAATCC 1 chr19:40447852-40447872 ( 13) GGAAGTCC 1 chr1:203398155-203398175 ( 3) GAAAATCC 1 chr11:7552407-7552427 ( 3) GAAAGTCC 1 chr8:70673310-70673330 ( 10) GAAAGTCC 1 chr17:64981637-64981657 ( 4) GAAAGTCC 1 chr13:71865518-71865538 ( 6) GAAAGTCC 1 chr4:38821341-38821361 ( 7) GAAAGTCC 1 chr3:55642046-55642066 ( 9) GAAAGTCC 1 chr4:185274711-185274731 ( 1) GAAATCCC 1 chr3:177096150-177096170 ( 3) GGATTCCC 1 chr7:5740973-5740993 ( 10) GGAACTCC 1 chr1:32666957-32666977 ( 13) GGAAACCC 1 chr22:21104976-21104996 ( 1) GAAACTCC 1 chr7:5622364-5622384 ( 8) GAAACTCC 1 chr17:27215059-27215079 ( 2) GGGTTTCC 1 chr3:193460605-193460625 ( 1) GGGTTTCC 1 chr17:8888547-8888567 ( 10) GCAATTCC 1 chr11:14335868-14335888 ( 5) GGGTTTCC 1 chr15:60874740-60874760 ( 10) GGGTTTCC 1 chr16:10915275-10915295 ( 6) GAAAACCC 1 chr15:31548123-31548143 ( 13) GGATCTCC 1 chr7:20338201-20338221 ( 3) GAAAACCC 1 chr3:19972960-19972980 ( 12) GAAAACCC 1 chr15:57833117-57833137 ( 10) GGTTTTCC 1 chr4:10734115-10734135 ( 3) GGTTTTCC 1 chr7:50332122-50332142 ( 1) GGTTTTCC 1 chr10:11667162-11667182 ( 4) GGTTTTCC 1 chr18:60825108-60825128 ( 7) GAGTTTCC 1 chr3:121823776-121823796 ( 2) GAAATACC 1 chr10:108691375-10869139 ( 1) GAAAGCCC 1 chr17:39832752-39832772 ( 11) GAAAGCCC 1 chr2:192798212-192798232 ( 9) GAAAGCCC 1 chr13:52393513-52393533 ( 7) GCATTTCC 1 chr6:89471610-89471630 ( 2) GGTAATCC 1 chrX:1447013-1447033 ( 13) GGCTTTCC 1 chr19:6661950-6661970 ( 9) GCATTTCC 1 chr1:200122624-200122644 ( 12) GGCTTTCC 1 chrX:87155451-87155471 ( 2) GACTTTCC 1 chr3:119419575-119419595 ( 7) GACTTTCC 1 chr16:48942302-48942322 ( 1) GAATTACC 1 chr11:60134662-60134682 ( 6) GAAATTCA 1 chr6:3209840-3209860 ( 2) GAGAGTCC 1 chr17:27476746-27476766 ( 10) GGACTTCC 1 chr5:71772777-71772797 ( 8) GGAAATCA 1 chr18:28848258-28848278 ( 9) GTATTTCC 1 chr19:6543955-6543975 ( 12) GGTTTCCC 1 chr7:37823816-37823836 ( 1) GAATGACC 1 chr8:142117086-142117106 ( 8) GAGATACC 1 chr1:37943030-37943050 ( 1) GAATTCCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GRAWTTCC MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.33375 E= 2.8e-046 -1279 -1279 199 -1279 69 -249 113 -424 163 -207 -135 -166 127 -407 -1279 56 -12 -207 -57 104 -212 -62 -1279 156 -1279 207 -1279 -1279 -253 201 -1279 -1279 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GRAWTTCC MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 71 E= 2.8e-046 0.000000 0.000000 1.000000 0.000000 0.394366 0.042254 0.549296 0.014085 0.760563 0.056338 0.098592 0.084507 0.591549 0.014085 0.000000 0.394366 0.225352 0.056338 0.169014 0.549296 0.056338 0.154930 0.000000 0.788732 0.000000 1.000000 0.000000 0.000000 0.042254 0.957746 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GRAWTTCC MEME-1 regular expression -------------------------------------------------------------------------------- G[GA]A[AT][TA]TCC -------------------------------------------------------------------------------- Time 1.93 secs. ******************************************************************************** ******************************************************************************** MOTIF AGGGRCTT MEME-2 width = 8 sites = 8 llr = 77 E-value = 1.2e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif AGGGRCTT MEME-2 Description -------------------------------------------------------------------------------- Simplified A a:::61:: pos.-specific C :::::9:: probability G :aaa4::1 matrix T ::::::a9 bits 2.1 **** 1.9 **** * 1.7 **** * 1.5 **** *** Relative 1.2 **** *** Entropy 1.0 ******** (13.9 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AGGGACTT consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGRCTT MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr22:40988895-40988915 13 1.60e-05 GCATTGGCTC AGGGACTT chr22:35450239-35450259 13 1.60e-05 tacttaccta agggactt chr21:16197885-16197905 11 1.60e-05 GGAAACCACC AGGGACTT CA chr16:31276858-31276878 12 1.60e-05 GTGAACACAT AGGGACTT T chr13:47242268-47242288 13 3.25e-05 AGCAGGAAAA AGGGGCTT chr1:173387552-173387572 2 3.25e-05 C AGGGGCTT TTGGGGTGAC chr7:37823816-37823836 9 4.75e-05 gaatgacc agggactg cccc chr14:76006655-76006675 12 9.66e-05 CCCCTCCAGT AGGGGATT T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGRCTT MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr22:40988895-40988915 1.6e-05 12_[+2] chr22:35450239-35450259 1.6e-05 12_[+2] chr21:16197885-16197905 1.6e-05 10_[+2]_2 chr16:31276858-31276878 1.6e-05 11_[+2]_1 chr13:47242268-47242288 3.2e-05 12_[+2] chr1:173387552-173387572 3.2e-05 1_[+2]_11 chr7:37823816-37823836 4.8e-05 8_[+2]_4 chr14:76006655-76006675 9.7e-05 11_[+2]_1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGRCTT MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AGGGRCTT width=8 seqs=8 chr22:40988895-40988915 ( 13) AGGGACTT 1 chr22:35450239-35450259 ( 13) AGGGACTT 1 chr21:16197885-16197905 ( 11) AGGGACTT 1 chr16:31276858-31276878 ( 12) AGGGACTT 1 chr13:47242268-47242288 ( 13) AGGGGCTT 1 chr1:173387552-173387572 ( 2) AGGGGCTT 1 chr7:37823816-37823836 ( 9) AGGGACTG 1 chr14:76006655-76006675 ( 12) AGGGGATT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGRCTT MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.88856 E= 1.2e+002 203 -965 -965 -965 -965 -965 199 -965 -965 -965 199 -965 -965 -965 199 -965 135 -965 58 -965 -97 188 -965 -965 -965 -965 -965 191 -965 -965 -100 171 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGRCTT MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 8 E= 1.2e+002 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.625000 0.000000 0.375000 0.000000 0.125000 0.875000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.125000 0.875000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGRCTT MEME-2 regular expression -------------------------------------------------------------------------------- AGGG[AG]CTT -------------------------------------------------------------------------------- Time 2.64 secs. ******************************************************************************** ******************************************************************************** MOTIF CHCABWCT MEME-3 width = 8 sites = 22 llr = 154 E-value = 9.4e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif CHCABWCT MEME-3 Description -------------------------------------------------------------------------------- Simplified A :3:a13:: pos.-specific C a3a:228: probability G ::::4::: matrix T :5::352a bits 2.1 * * 1.9 * * * 1.7 * ** * 1.5 * ** * Relative 1.2 * ** ** Entropy 1.0 * ** ** (10.1 bits) 0.8 * ** ** 0.6 * ** ** 0.4 **** *** 0.2 **** *** 0.0 -------- Multilevel CTCAGTCT consensus A TAT sequence C -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CHCABWCT MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:235927478-235927498 13 1.56e-05 ggaaatcccc ctcagtct chr12:31358081-31358101 3 1.56e-05 TT CTCAGTCT ACGCATGGGA chr17:9292587-9292607 6 7.46e-05 CTAAC CACAGTCT ATTAAGA chr19:50398703-50398723 9 1.05e-04 TGGGCTGG CCCATTCT CATT chr19:6543955-6543975 2 1.05e-04 C CCCATTCT GAGGTTTCCC chr4:110926818-110926838 9 1.34e-04 ACAGGCTA CACATTCT TGAA chr11:8553675-8553695 9 1.47e-04 ggccccat cccagact gatt chr2:203037816-203037836 9 1.47e-04 CTACACAG CCCAGACT GGGG chr1:183150104-183150124 12 2.03e-04 CTTCCAGGGC CTCAGCCT T chr12:31451641-31451661 5 2.03e-04 TCAG CCCATACT ACTTTGCC chr1:37943030-37943050 11 3.29e-04 GAATTCCAGC CTCAAACT TC chr1:203398155-203398175 12 3.29e-04 ggaaaatccc ctcaaact t chr2:145116636-145116656 4 3.67e-04 GAC CACAGCCT AAAAATGCA chr5:114404693-114404713 13 4.12e-04 GCAGCTATGA CTCATTTT chr5:18746565-18746585 8 4.12e-04 GCTGTGA CTCATTTT GGCTT chr2:24810007-24810027 11 4.12e-04 tgctccaaac cacacact gt chr5:139419331-139419351 10 4.12e-04 CAGAACCTA CACACACT CAG chr6:150958132-150958152 2 4.82e-04 t cccagttt tagctctgaa chr15:76352789-76352809 4 6.30e-04 TCC CACACCCT GAGGATTTG chrX:12969562-12969582 2 7.05e-04 T CTCAATTT GGGTTTTTCC chr15:96518631-96518651 12 7.94e-04 acctggacta ctcatctt c chr19:42970105-42970125 2 1.19e-03 T CTCTCTCT GTCCTGTTGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CHCABWCT MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:235927478-235927498 1.6e-05 12_[+3] chr12:31358081-31358101 1.6e-05 2_[+3]_10 chr17:9292587-9292607 7.5e-05 5_[+3]_7 chr19:50398703-50398723 0.0001 8_[+3]_4 chr19:6543955-6543975 0.0001 1_[+3]_11 chr4:110926818-110926838 0.00013 8_[+3]_4 chr11:8553675-8553695 0.00015 8_[+3]_4 chr2:203037816-203037836 0.00015 8_[+3]_4 chr1:183150104-183150124 0.0002 11_[+3]_1 chr12:31451641-31451661 0.0002 4_[+3]_8 chr1:37943030-37943050 0.00033 10_[+3]_2 chr1:203398155-203398175 0.00033 11_[+3]_1 chr2:145116636-145116656 0.00037 3_[+3]_9 chr5:114404693-114404713 0.00041 12_[+3] chr5:18746565-18746585 0.00041 7_[+3]_5 chr2:24810007-24810027 0.00041 10_[+3]_2 chr5:139419331-139419351 0.00041 9_[+3]_3 chr6:150958132-150958152 0.00048 1_[+3]_11 chr15:76352789-76352809 0.00063 3_[+3]_9 chrX:12969562-12969582 0.0007 1_[+3]_11 chr15:96518631-96518651 0.00079 11_[+3]_1 chr19:42970105-42970125 0.0012 1_[+3]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CHCABWCT MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CHCABWCT width=8 seqs=22 chr1:235927478-235927498 ( 13) CTCAGTCT 1 chr12:31358081-31358101 ( 3) CTCAGTCT 1 chr17:9292587-9292607 ( 6) CACAGTCT 1 chr19:50398703-50398723 ( 9) CCCATTCT 1 chr19:6543955-6543975 ( 2) CCCATTCT 1 chr4:110926818-110926838 ( 9) CACATTCT 1 chr11:8553675-8553695 ( 9) CCCAGACT 1 chr2:203037816-203037836 ( 9) CCCAGACT 1 chr1:183150104-183150124 ( 12) CTCAGCCT 1 chr12:31451641-31451661 ( 5) CCCATACT 1 chr1:37943030-37943050 ( 11) CTCAAACT 1 chr1:203398155-203398175 ( 12) CTCAAACT 1 chr2:145116636-145116656 ( 4) CACAGCCT 1 chr5:114404693-114404713 ( 13) CTCATTTT 1 chr5:18746565-18746585 ( 8) CTCATTTT 1 chr2:24810007-24810027 ( 11) CACACACT 1 chr5:139419331-139419351 ( 10) CACACACT 1 chr6:150958132-150958152 ( 2) CCCAGTTT 1 chr15:76352789-76352809 ( 4) CACACCCT 1 chrX:12969562-12969582 ( 2) CTCAATTT 1 chr15:96518631-96518651 ( 12) CTCATCTT 1 chr19:42970105-42970125 ( 2) CTCTCTCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CHCABWCT MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.74595 E= 9.4e+002 -1110 207 -1110 -1110 15 20 -1110 77 -1110 207 -1110 -1110 196 -1110 -1110 -255 -84 -38 53 26 38 -38 -1110 91 -1110 170 -1110 -23 -1110 -1110 -1110 191 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CHCABWCT MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 22 E= 9.4e+002 0.000000 1.000000 0.000000 0.000000 0.272727 0.272727 0.000000 0.454545 0.000000 1.000000 0.000000 0.000000 0.954545 0.000000 0.000000 0.045455 0.136364 0.181818 0.363636 0.318182 0.318182 0.181818 0.000000 0.500000 0.000000 0.772727 0.000000 0.227273 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CHCABWCT MEME-3 regular expression -------------------------------------------------------------------------------- C[TAC]CA[GT][TA][CT]T -------------------------------------------------------------------------------- Time 5.18 secs. ******************************************************************************** ******************************************************************************** MOTIF TCCCAGGK MEME-4 width = 8 sites = 10 llr = 86 E-value = 2.7e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCCCAGGK MEME-4 Description -------------------------------------------------------------------------------- Simplified A 2:::a3:: pos.-specific C :9aa::2: probability G :::::786 matrix T 81:::::4 bits 2.1 *** 1.9 *** 1.7 **** 1.5 **** Relative 1.2 ***** * Entropy 1.0 ******** (12.4 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TCCCAGGG consensus A ACT sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCCAGGK MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr12:121998458-12199847 8 1.38e-05 GGTCCTT TCCCAGGG GCGAG chr8:91640262-91640282 13 1.38e-05 GCACTTCTGA TCCCAGGG chr6:36723713-36723733 4 1.38e-05 ATT TCCCAGGG TAGGGGCCC chr7:111696595-111696615 10 4.19e-05 gggaattcc tcccaagg gaa chrX:13276278-13276298 6 5.62e-05 aagtt tcccaagt gactcta chr17:57923777-57923797 5 1.09e-04 ATCA ACCCAGGT GTCCAACC chr10:92759416-92759436 4 1.09e-04 AGT TCCCAGCT AGGGCTTAG chr17:27065875-27065895 9 1.09e-04 CTCTAGCT TCCCAGCT GCAC chr2:175473359-175473379 6 1.34e-04 TTGCA ACCCAAGG GAGAAAC chr1:183150104-183150124 3 1.50e-04 AC TTCCAGGG CCTCAGCCTT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCCAGGK MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:121998458-12199847 1.4e-05 7_[+4]_5 chr8:91640262-91640282 1.4e-05 12_[+4] chr6:36723713-36723733 1.4e-05 3_[+4]_9 chr7:111696595-111696615 4.2e-05 9_[+4]_3 chrX:13276278-13276298 5.6e-05 5_[+4]_7 chr17:57923777-57923797 0.00011 4_[+4]_8 chr10:92759416-92759436 0.00011 3_[+4]_9 chr17:27065875-27065895 0.00011 8_[+4]_4 chr2:175473359-175473379 0.00013 5_[+4]_7 chr1:183150104-183150124 0.00015 2_[+4]_10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCCAGGK MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCCCAGGK width=8 seqs=10 chr12:121998458-12199847 ( 8) TCCCAGGG 1 chr8:91640262-91640282 ( 13) TCCCAGGG 1 chr6:36723713-36723733 ( 4) TCCCAGGG 1 chr7:111696595-111696615 ( 10) TCCCAAGG 1 chrX:13276278-13276298 ( 6) TCCCAAGT 1 chr17:57923777-57923797 ( 5) ACCCAGGT 1 chr10:92759416-92759436 ( 4) TCCCAGCT 1 chr17:27065875-27065895 ( 9) TCCCAGCT 1 chr2:175473359-175473379 ( 6) ACCCAAGG 1 chr1:183150104-183150124 ( 3) TTCCAGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCCAGGK MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.5921 E= 2.7e+003 -29 -997 -997 158 -997 192 -997 -141 -997 207 -997 -997 -997 207 -997 -997 203 -997 -997 -997 29 -997 148 -997 -997 -25 167 -997 -997 -997 126 58 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCCAGGK MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 10 E= 2.7e+003 0.200000 0.000000 0.000000 0.800000 0.000000 0.900000 0.000000 0.100000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.300000 0.000000 0.700000 0.000000 0.000000 0.200000 0.800000 0.000000 0.000000 0.000000 0.600000 0.400000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCCCAGGK MEME-4 regular expression -------------------------------------------------------------------------------- [TA]CCCA[GA][GC][GT] -------------------------------------------------------------------------------- Time 7.79 secs. ******************************************************************************** ******************************************************************************** MOTIF CCCCTCCA MEME-5 width = 8 sites = 2 llr = 23 E-value = 3.0e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCCCTCCA MEME-5 Description -------------------------------------------------------------------------------- Simplified A :::::::a pos.-specific C aaaa:aa: probability G :::::::: matrix T ::::a::: bits 2.1 **** *** 1.9 ******** 1.7 ******** 1.5 ******** Relative 1.2 ******** Entropy 1.0 ******** (16.4 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CCCCTCCA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCTCCA MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr21:45377579-45377599 6 1.16e-05 GTTTC CCCCTCCA CACGGGG chr14:76006655-76006675 2 1.16e-05 G CCCCTCCA GTAGGGGATT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCTCCA MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr21:45377579-45377599 1.2e-05 5_[+5]_7 chr14:76006655-76006675 1.2e-05 1_[+5]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCTCCA MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCCCTCCA width=8 seqs=2 chr21:45377579-45377599 ( 6) CCCCTCCA 1 chr14:76006655-76006675 ( 2) CCCCTCCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCTCCA MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.6653 E= 3.0e+003 -765 207 -765 -765 -765 207 -765 -765 -765 207 -765 -765 -765 207 -765 -765 -765 -765 -765 190 -765 207 -765 -765 -765 207 -765 -765 202 -765 -765 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCTCCA MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 3.0e+003 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCTCCA MEME-5 regular expression -------------------------------------------------------------------------------- CCCCTCCA -------------------------------------------------------------------------------- Time 10.22 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:142231223-142231243 7.89e-03 20 chr1:200122624-200122644 6.98e-04 8_[+2(3.25e-05)]_4 chr19:6661950-6661970 6.62e-02 20 chr2:203037816-203037836 3.12e-02 20 chrX:13276278-13276298 4.02e-03 5_[+4(5.62e-05)]_7 chr5:122037770-122037790 9.47e-02 20 chr1:173387552-173387572 2.55e-02 1_[+2(3.25e-05)]_11 chr3:57773774-57773794 8.88e-01 20 chr20:32471112-32471132 6.33e-02 9_[+1(7.64e-05)]_3 chr10:11667162-11667182 8.74e-05 8_[+4(1.38e-05)]_4 chr2:65166885-65166905 3.44e-01 20 chr1:32666957-32666977 2.07e-01 20 chrX:12969562-12969582 1.84e-02 20 chr15:31804112-31804132 8.81e-02 20 chr15:83869167-83869187 3.06e-02 20 chr3:189285722-189285742 7.03e-01 20 chr12:32405611-32405631 1.12e-02 9_[+1(7.64e-05)]_3 chr16:48942302-48942322 1.71e-01 20 chr4:36327318-36327338 8.05e-06 4_[+1(4.64e-05)]_8 chr17:38480386-38480406 2.51e-01 20 chr2:38666188-38666208 4.20e-02 20 chr12:11983329-11983349 6.76e-01 20 chr8:81395159-81395179 9.12e-01 20 chr2:60674013-60674033 7.34e-01 20 chr12:31451641-31451661 6.11e-02 20 chr3:55642046-55642066 7.95e-02 20 chr11:10476732-10476752 6.78e-01 20 chr6:36723713-36723733 4.81e-03 3_[+4(1.38e-05)]_9 chr3:46003689-46003709 6.66e-01 20 chr19:6543955-6543975 8.69e-04 20 chr14:35625416-35625436 9.30e-01 20 chr1:75197946-75197966 1.16e-02 20 chrX:1447013-1447033 1.54e-03 9_[+2(3.25e-05)]_3 chr15:60874740-60874760 5.15e-02 20 chr17:29288389-29288409 9.91e-01 20 chr6:107293055-107293075 4.11e-04 5_[+1(7.64e-05)]_7 chr21:26882382-26882402 9.78e-01 20 chr2:192531586-192531606 8.57e-01 20 chr14:89743004-89743024 2.66e-02 20 chr16:24986928-24986948 8.73e-02 20 chr7:37823816-37823836 1.31e-03 8_[+2(4.75e-05)]_4 chr2:9240694-9240714 7.37e-01 20 chr3:177096150-177096170 2.12e-04 20 chr15:41775451-41775471 8.29e-04 7_[+1(1.51e-05)]_5 chr7:122830380-122830400 6.39e-02 20 chr5:139419331-139419351 1.17e-01 20 chr1:175567333-175567353 6.02e-01 20 chr15:96518631-96518651 9.65e-02 20 chr5:143569521-143569541 5.84e-03 5_[+1(7.64e-05)]_7 chr7:50332122-50332142 3.44e-02 20 chr9:108304357-108304377 7.27e-01 20 chr16:31276858-31276878 1.25e-02 11_[+2(1.60e-05)]_1 chr3:29323606-29323626 7.78e-01 20 chr13:47152879-47152899 4.27e-01 20 chr2:192798212-192798232 6.83e-02 20 chr2:145116636-145116656 1.52e-01 20 chr12:1532320-1532340 9.34e-02 20 chr1:153235431-153235451 1.90e-01 20 chr9:136822512-136822532 9.75e-01 20 chr7:43775565-43775585 9.83e-01 20 chr4:8536095-8536115 5.72e-04 11_[+1(1.51e-05)]_1 chr22:18586845-18586865 8.43e-01 20 chr3:28982150-28982170 9.94e-01 20 chr3:46335849-46335869 2.92e-01 20 chr10:122611187-12261120 6.61e-01 20 chr5:142415859-142415879 7.01e-01 20 chr10:70813675-70813695 3.10e-01 20 chr12:4255618-4255638 2.49e-01 20 chr4:10734115-10734135 2.65e-02 20 chr4:185274711-185274731 1.04e-02 20 chr2:55361182-55361202 3.41e-02 20 chr2:238661696-238661716 9.37e-01 20 chr8:66858336-66858356 3.56e-02 20 chr5:40224133-40224153 3.81e-01 20 chr16:10936952-10936972 1.77e-01 20 chr8:142416423-142416443 6.53e-01 20 chr12:31358081-31358101 1.62e-02 2_[+3(1.56e-05)]_10 chr2:24810007-24810027 3.39e-02 20 chr2:136814667-136814687 8.83e-01 20 chr1:236588747-236588767 2.70e-01 20 chr11:72858889-72858909 4.07e-03 20 chr6:378277-378297 6.26e-04 3_[+1(4.64e-05)]_9 chr11:14335868-14335888 1.91e-03 20 chr17:8888547-8888567 8.24e-02 20 chr10:90754027-90754047 2.18e-01 20 chr3:170074182-170074202 1.00e+00 20 chr13:47242268-47242288 7.05e-02 12_[+2(3.25e-05)] chr4:38821341-38821361 1.79e-02 20 chr1:235927478-235927498 2.16e-06 2_[+1(7.64e-05)]_2_[+3(1.56e-05)] chr6:44703550-44703570 1.25e-02 20 chr17:25544805-25544825 3.56e-01 20 chr8:10767747-10767767 8.86e-01 20 chr15:57833117-57833137 1.10e-01 20 chr21:16197885-16197905 1.88e-04 10_[+2(1.60e-05)]_2 chr5:140890931-140890951 6.83e-01 20 chr6:12370254-12370274 8.34e-01 20 chr15:99780208-99780228 1.56e-01 20 chr14:76006655-76006675 6.57e-05 1_[+5(1.16e-05)]_2_[+2(9.66e-05)]_1 chr17:9292587-9292607 4.71e-02 5_[+3(7.46e-05)]_7 chr1:203398155-203398175 3.86e-05 20 chr5:130715557-130715577 9.81e-01 20 chr7:5740973-5740993 3.96e-02 20 chr12:11975239-11975259 8.87e-01 20 chr11:61772112-61772132 9.99e-01 20 chr5:131856656-131856676 2.56e-03 1_[+1(7.64e-05)]_11 chr3:119419575-119419595 6.98e-03 20 chr18:56317518-56317538 8.80e-02 20 chrX:78179317-78179337 1.86e-01 20 chr1:42416708-42416728 2.85e-01 20 chr12:111842452-11184247 2.75e-01 20 chr8:142117086-142117106 2.21e-01 20 chr18:57514585-57514605 1.50e-01 20 chr11:116934036-11693405 7.61e-01 20 chr19:10330627-10330647 4.28e-03 9_[+1(1.51e-05)]_3 chr16:23335199-23335219 2.13e-01 20 chr17:39832752-39832772 2.85e-01 20 chr8:62007873-62007893 2.30e-02 7_[+1(7.64e-05)]_5 chr15:57592124-57592144 1.34e-01 20 chr2:175473359-175473379 2.20e-02 20 chr15:61191658-61191678 9.79e-01 20 chr11:117815998-11781601 2.55e-01 20 chr13:111573747-11157376 4.50e-01 20 chr8:22932316-22932336 3.29e-01 20 chrX:46569967-46569987 8.96e-02 20 chr1:183150104-183150124 6.21e-05 20 chr11:102216780-10221680 6.65e-01 20 chr4:103422480-103422500 7.44e-01 20 chr12:11718800-11718820 1.65e-01 20 chr11:118314406-11831442 1.80e-01 20 chr2:242067244-242067264 6.89e-01 20 chr2:68654540-68654560 5.77e-04 2_[+1(7.64e-05)]_10 chr12:11933880-11933900 7.18e-01 20 chr14:35630638-35630658 4.70e-01 20 chr15:96601837-96601857 9.57e-01 20 chr9:123683217-123683237 2.46e-01 20 chr11:10510634-10510654 6.79e-01 20 chr19:50414757-50414777 5.46e-06 2_[+1(7.64e-05)]_10 chr9:37378321-37378341 8.16e-01 20 chr17:27065875-27065895 1.06e-02 20 chr22:35450239-35450259 3.73e-03 12_[+2(1.60e-05)] chr7:5622364-5622384 3.18e-02 20 chr11:94317513-94317533 7.17e-01 20 chr3:19972960-19972980 3.60e-02 20 chr4:110926818-110926838 4.72e-02 20 chr3:15398352-15398372 1.05e-04 9_[+1(4.64e-05)]_3 chr9:140655634-140655654 1.60e-01 20 chr18:60818354-60818374 9.40e-01 20 chr22:21104976-21104996 1.70e-02 20 chr3:121823776-121823796 3.98e-03 20 chr17:12334714-12334734 4.31e-01 20 chr13:71865518-71865538 1.84e-02 20 chr5:17278249-17278269 4.88e-01 20 chr3:193460605-193460625 5.20e-02 20 chr1:37943030-37943050 3.19e-03 20 chr4:113209756-113209776 1.25e-01 20 chr17:64981637-64981657 4.47e-03 20 chr11:8553675-8553695 2.24e-03 20 chr3:122417262-122417282 1.25e-01 20 chr6:3209840-3209860 1.04e-02 20 chr7:20338201-20338221 1.48e-02 20 chr1:221948699-221948719 8.79e-01 20 chr22:40988895-40988915 9.41e-03 12_[+2(1.60e-05)] chr2:197201592-197201612 6.04e-01 20 chr7:26196132-26196152 1.83e-03 10_[+1(1.51e-05)]_2 chr2:80752502-80752522 5.16e-04 2_[+1(4.64e-05)]_10 chr16:75186708-75186728 6.26e-01 20 chr2:106419296-106419316 2.59e-04 2_[+1(1.51e-05)]_10 chr3:143551421-143551441 3.63e-01 20 chr3:131450757-131450777 6.71e-01 20 chr15:31548123-31548143 3.84e-02 20 chr8:103567744-103567764 1.15e-01 20 chr5:132657740-132657760 4.69e-01 20 chr18:28848258-28848278 4.13e-02 20 chr1:203350455-203350475 5.75e-01 20 chr9:71417819-71417839 4.68e-01 20 chr18:60828446-60828466 9.98e-01 20 chr6:152481636-152481656 7.88e-01 20 chr6:89471610-89471630 3.71e-02 20 chr7:111696595-111696615 5.65e-05 1_[+1(1.51e-05)]_[+4(4.19e-05)]_3 chr15:76352789-76352809 1.32e-02 20 chr19:50398703-50398723 3.22e-02 20 chr6:137051985-137052005 6.63e-01 20 chr2:217087922-217087942 9.16e-01 20 chr8:126221601-126221621 1.23e-01 20 chr4:146981197-146981217 8.90e-01 20 chr9:126518972-126518992 7.12e-03 8_[+5(7.91e-05)]_4 chr2:145122694-145122714 3.90e-01 20 chr7:50420128-50420148 7.64e-01 20 chr12:108961963-10896198 6.07e-01 20 chr6:150958132-150958152 2.37e-02 20 chr8:70673310-70673330 4.34e-02 20 chr8:72751403-72751423 9.36e-01 20 chr10:92759416-92759436 3.50e-03 20 chr11:7552407-7552427 4.58e-02 20 chr8:65669526-65669546 8.46e-02 20 chr18:56301275-56301295 7.45e-01 20 chr6:12119499-12119519 4.45e-01 20 chr7:134873627-134873647 6.88e-01 20 chr5:18746565-18746585 6.92e-02 20 chr17:57923777-57923797 4.12e-02 20 chr16:10915275-10915295 6.31e-02 20 chr12:90354132-90354152 4.62e-01 20 chr5:64344280-64344300 4.26e-01 20 chr2:85166987-85167007 7.20e-01 20 chr1:156135058-156135078 4.75e-02 20 chr4:105411410-105411430 9.72e-01 20 chr12:78140120-78140140 1.33e-03 4_[+1(7.64e-05)]_8 chr17:27215059-27215079 6.57e-02 20 chr6:155502833-155502853 5.27e-01 20 chr10:81091674-81091694 3.45e-01 20 chr6:43682871-43682891 8.79e-01 20 chr8:91640262-91640282 8.14e-03 12_[+4(1.38e-05)] chr6:138194671-138194691 4.78e-01 20 chr12:121998458-12199847 1.72e-03 7_[+4(1.38e-05)]_5 chr13:52393513-52393533 1.66e-03 20 chr6:13274225-13274245 5.40e-01 20 chr15:68325207-68325227 8.90e-02 20 chr15:70433185-70433205 7.72e-01 20 chr6:11825335-11825355 2.89e-01 20 chr10:61641111-61641131 2.58e-01 20 chrX:87155451-87155471 1.28e-01 20 chr18:60826341-60826361 7.98e-01 20 chr11:117480944-11748096 4.44e-01 20 chr17:39495306-39495326 6.86e-01 20 chr2:223288498-223288518 9.77e-01 20 chr11:103830148-10383016 9.36e-01 20 chr5:114404693-114404713 8.26e-02 20 chr3:179601096-179601116 8.54e-01 20 chr1:9686362-9686382 6.90e-02 20 chr12:69964732-69964752 6.88e-01 20 chr9:132695263-132695283 2.06e-01 20 chr17:27476746-27476766 3.23e-03 20 chr1:159047205-159047225 2.84e-01 20 chr9:136285778-136285798 4.70e-01 20 chr3:148943164-148943184 8.54e-01 20 chr18:60825108-60825128 8.88e-04 20 chr19:42970105-42970125 3.90e-01 20 chr19:40447852-40447872 5.50e-03 20 chr21:45377579-45377599 3.53e-03 5_[+5(1.16e-05)]_7 chr12:122900943-12290096 3.34e-01 20 chr21:45592686-45592706 7.96e-01 20 chr14:53647533-53647553 3.17e-01 20 chr10:108691375-10869139 6.93e-03 20 chr16:69598017-69598037 6.65e-03 8_[+1(4.64e-05)]_4 chr7:44790713-44790733 6.39e-01 20 chr8:24245189-24245209 4.47e-01 20 chr14:94812805-94812825 8.17e-01 20 chr5:71772777-71772797 3.91e-01 20 chr8:81987060-81987080 4.33e-03 10_[+1(2.99e-05)]_2 chr11:60134662-60134682 6.51e-03 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n10.farnam.hpc.yale.internal ********************************************************************************