******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/RBBP5.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr6:106960469-106960489 1.0000 20 chr5:64778805-64778825 1.0000 20 chr12:83080450-83080470 1.0000 20 chr10:91174378-91174398 1.0000 20 chrX:1408625-1408645 1.0000 20 chr9:31347119-31347139 1.0000 20 chr9:69786651-69786671 1.0000 20 chr10:17601654-17601674 1.0000 20 chr4:169401553-169401573 1.0000 20 chr1:111329832-111329852 1.0000 20 chr1:47082291-47082311 1.0000 20 chr20:42285498-42285518 1.0000 20 chr18:24559067-24559087 1.0000 20 chr18:9095618-9095638 1.0000 20 chr8:67026146-67026166 1.0000 20 chrX:44732757-44732777 1.0000 20 chr13:22636251-22636271 1.0000 20 chr10:6019593-6019613 1.0000 20 chr16:3676522-3676542 1.0000 20 chr19:7242907-7242927 1.0000 20 chr2:101197633-101197653 1.0000 20 chr22:18632781-18632801 1.0000 20 chr2:152118205-152118225 1.0000 20 chr3:143248251-143248271 1.0000 20 chr12:104888418-10488843 1.0000 20 chr17:59981845-59981865 1.0000 20 chr17:53046447-53046467 1.0000 20 chr11:6767864-6767884 1.0000 20 chr4:147096985-147097005 1.0000 20 chr21:40556052-40556072 1.0000 20 chr9:102669161-102669181 1.0000 20 chr6:26322625-26322645 1.0000 20 chr6:101329009-101329029 1.0000 20 chr14:20811097-20811117 1.0000 20 chr12:12849451-12849471 1.0000 20 chr3:31574505-31574525 1.0000 20 chr1:59434293-59434313 1.0000 20 chr5:131439361-131439381 1.0000 20 chr7:148638233-148638253 1.0000 20 chr10:99408665-99408685 1.0000 20 chr3:105088230-105088250 1.0000 20 chr1:158978570-158978590 1.0000 20 chr16:84674797-84674817 1.0000 20 chr2:133023539-133023559 1.0000 20 chr10:90734965-90734985 1.0000 20 chr3:113251410-113251430 1.0000 20 chr1:21503277-21503297 1.0000 20 chr20:61282927-61282947 1.0000 20 chr3:197121339-197121359 1.0000 20 chr4:156874963-156874983 1.0000 20 chr6:28696938-28696958 1.0000 20 chr11:93862210-93862230 1.0000 20 chr10:45957854-45957874 1.0000 20 chr11:58910398-58910418 1.0000 20 chr10:92980569-92980589 1.0000 20 chr14:35099033-35099053 1.0000 20 chr10:23304273-23304293 1.0000 20 chr17:47647206-47647226 1.0000 20 chr1:175111392-175111412 1.0000 20 chr15:70489330-70489350 1.0000 20 chr6:111803569-111803589 1.0000 20 chr3:101395688-101395708 1.0000 20 chr14:60559123-60559143 1.0000 20 chr9:123834094-123834114 1.0000 20 chr10:76499079-76499099 1.0000 20 chr10:5726892-5726912 1.0000 20 chr4:177241246-177241266 1.0000 20 chr14:55094721-55094741 1.0000 20 chr5:176839879-176839899 1.0000 20 chr6:52356290-52356310 1.0000 20 chr13:41886077-41886097 1.0000 20 chr1:35734573-35734593 1.0000 20 chr16:71850985-71851005 1.0000 20 chr5:180634148-180634168 1.0000 20 chr9:69786918-69786938 1.0000 20 chr6:27661932-27661952 1.0000 20 chr6:28863695-28863715 1.0000 20 chr18:31280705-31280725 1.0000 20 chr4:170533499-170533519 1.0000 20 chr7:148660128-148660148 1.0000 20 chr6:121655976-121655996 1.0000 20 chr14:72022186-72022206 1.0000 20 chr4:47487467-47487487 1.0000 20 chr6:126101661-126101681 1.0000 20 chr2:133026772-133026792 1.0000 20 chr13:42614458-42614478 1.0000 20 chr6:126101877-126101897 1.0000 20 chr13:76124036-76124056 1.0000 20 chr16:68790739-68790759 1.0000 20 chr11:121163772-12116379 1.0000 20 chr5:88030965-88030985 1.0000 20 chr9:100881384-100881404 1.0000 20 chr12:12849711-12849731 1.0000 20 chr1:143539797-143539817 1.0000 20 chr5:96212226-96212246 1.0000 20 chr5:49963814-49963834 1.0000 20 chr15:45459419-45459439 1.0000 20 chr1:22192613-22192633 1.0000 20 chr11:109827255-10982727 1.0000 20 chr5:124316348-124316368 1.0000 20 chr11:86792572-86792592 1.0000 20 chr11:102345337-10234535 1.0000 20 chr19:4214728-4214748 1.0000 20 chr2:201753440-201753460 1.0000 20 chr10:112116860-11211688 1.0000 20 chr13:41634215-41634235 1.0000 20 chr7:130598028-130598048 1.0000 20 chr2:179343254-179343274 1.0000 20 chr12:102271177-10227119 1.0000 20 chr6:21004268-21004288 1.0000 20 chr3:101232214-101232234 1.0000 20 chr10:73529001-73529021 1.0000 20 chr6:42742817-42742837 1.0000 20 chr13:98628993-98629013 1.0000 20 chr8:38854722-38854742 1.0000 20 chr2:7049895-7049915 1.0000 20 chr19:39921997-39922017 1.0000 20 chr1:32538653-32538673 1.0000 20 chr3:37218007-37218027 1.0000 20 chr4:128802240-128802260 1.0000 20 chr5:88185322-88185342 1.0000 20 chr13:26760487-26760507 1.0000 20 chr20:43280932-43280952 1.0000 20 chr21:37661442-37661462 1.0000 20 chr2:149372194-149372214 1.0000 20 chr17:34418185-34418205 1.0000 20 chr6:14075494-14075514 1.0000 20 chr2:30670209-30670229 1.0000 20 chr2:136289269-136289289 1.0000 20 chr17:53046238-53046258 1.0000 20 chr11:43380826-43380846 1.0000 20 chr4:48782059-48782079 1.0000 20 chr1:87380748-87380768 1.0000 20 chr12:110517657-11051767 1.0000 20 chr14:64702648-64702668 1.0000 20 chr2:179343456-179343476 1.0000 20 chr2:175357802-175357822 1.0000 20 chr2:48667658-48667678 1.0000 20 chr6:33239998-33240018 1.0000 20 chr9:20623499-20623519 1.0000 20 chr6:27144931-27144951 1.0000 20 chr4:47487709-47487729 1.0000 20 chr6:20402250-20402270 1.0000 20 chr5:54048883-54048903 1.0000 20 chr12:111842618-11184263 1.0000 20 chr1:25074988-25075008 1.0000 20 chr9:19184290-19184310 1.0000 20 chr1:87523655-87523675 1.0000 20 chr12:40013603-40013623 1.0000 20 chr6:57385697-57385717 1.0000 20 chr16:14379536-14379556 1.0000 20 chr5:131746630-131746650 1.0000 20 chr1:230259439-230259459 1.0000 20 chr2:191224872-191224892 1.0000 20 chr4:120988215-120988235 1.0000 20 chr15:49087343-49087363 1.0000 20 chr10:38265215-38265235 1.0000 20 chr9:127951821-127951841 1.0000 20 chrX:15808481-15808501 1.0000 20 chr8:82066279-82066299 1.0000 20 chr10:120938150-12093817 1.0000 20 chr4:103997576-103997596 1.0000 20 chr3:49481788-49481808 1.0000 20 chr10:5727232-5727252 1.0000 20 chr1:94312288-94312308 1.0000 20 chr5:155829651-155829671 1.0000 20 chr5:95096443-95096463 1.0000 20 chr16:70438539-70438559 1.0000 20 chr5:96143659-96143679 1.0000 20 chr1:35658151-35658171 1.0000 20 chr13:48575259-48575279 1.0000 20 chr12:95611102-95611122 1.0000 20 chr1:75198933-75198953 1.0000 20 chr9:6750642-6750662 1.0000 20 chr14:97264089-97264109 1.0000 20 chr1:117910084-117910104 1.0000 20 chr2:54198262-54198282 1.0000 20 chr6:21589061-21589081 1.0000 20 chr20:50808016-50808036 1.0000 20 chr6:143268903-143268923 1.0000 20 chr8:124286525-124286545 1.0000 20 chr1:200597368-200597388 1.0000 20 chr10:101492101-10149212 1.0000 20 chr2:149402346-149402366 1.0000 20 chr14:75651504-75651524 1.0000 20 chr6:42847797-42847817 1.0000 20 chr15:77197561-77197581 1.0000 20 chr15:99789566-99789586 1.0000 20 chr17:63053259-63053279 1.0000 20 chr17:1101707-1101727 1.0000 20 chr13:24463195-24463215 1.0000 20 chr14:53575976-53575996 1.0000 20 chr12:68768416-68768436 1.0000 20 chr10:103949440-10394946 1.0000 20 chr15:52263917-52263937 1.0000 20 chr8:124169720-124169740 1.0000 20 chr11:62341198-62341218 1.0000 20 chr8:33412334-33412354 1.0000 20 chr13:53024437-53024457 1.0000 20 chr4:75072569-75072589 1.0000 20 chr17:4607332-4607352 1.0000 20 chr6:136611634-136611654 1.0000 20 chr19:14480962-14480982 1.0000 20 chr10:90145993-90146013 1.0000 20 chr22:34292885-34292905 1.0000 20 chr2:172750651-172750671 1.0000 20 chr6:116730885-116730905 1.0000 20 chr1:84543688-84543708 1.0000 20 chr1:40619164-40619184 1.0000 20 chr3:12882888-12882908 1.0000 20 chr3:48956003-48956023 1.0000 20 chr11:128480797-12848081 1.0000 20 chr1:38391891-38391911 1.0000 20 chr6:34393773-34393793 1.0000 20 chr11:82904586-82904606 1.0000 20 chr17:65809279-65809299 1.0000 20 chr13:76336696-76336716 1.0000 20 chr3:108308397-108308417 1.0000 20 chr20:5626412-5626432 1.0000 20 chr10:82231992-82232012 1.0000 20 chr6:88411824-88411844 1.0000 20 chr3:197677235-197677255 1.0000 20 chr17:55082551-55082571 1.0000 20 chr6:106440266-106440286 1.0000 20 chr10:25189970-25189990 1.0000 20 chr11:104839214-10483923 1.0000 20 chr2:67624505-67624525 1.0000 20 chr14:100706077-10070609 1.0000 20 chr6:28831672-28831692 1.0000 20 chr14:91790345-91790365 1.0000 20 chr4:83821561-83821581 1.0000 20 chr11:46143554-46143574 1.0000 20 chr14:65879908-65879928 1.0000 20 chr15:29562298-29562318 1.0000 20 chr20:29650766-29650786 1.0000 20 chr6:27573016-27573036 1.0000 20 chr12:113623096-11362311 1.0000 20 chr11:31531445-31531465 1.0000 20 chr20:37591120-37591140 1.0000 20 chr14:52313970-52313990 1.0000 20 chr9:20604929-20604949 1.0000 20 chr3:156202382-156202402 1.0000 20 chr8:132916655-132916675 1.0000 20 chr2:191399337-191399357 1.0000 20 chr18:5975085-5975105 1.0000 20 chr17:38804246-38804266 1.0000 20 chr17:59940758-59940778 1.0000 20 chr8:91658258-91658278 1.0000 20 chr3:148804205-148804225 1.0000 20 chr16:14702146-14702166 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_RBBP5/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/RBBP5.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.224 C 0.284 G 0.27 T 0.222 Background letter frequencies (from file dataset with add-one prior applied): A 0.224 C 0.284 G 0.27 T 0.222 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TTYVTTTY MEME-1 width = 8 sites = 17 llr = 131 E-value = 3.4e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTYVTTTY MEME-1 Description -------------------------------------------------------------------------------- Simplified A :::2:::: pos.-specific C :142:2:4 probability G :::5:2:: matrix T a961a5a6 bits 2.2 * * * 2.0 * * * 1.7 * * * 1.5 ** * * Relative 1.3 ** * * Entropy 1.1 *** * ** (11.1 bits) 0.9 *** * ** 0.7 *** **** 0.4 *** **** 0.2 ******** 0.0 -------- Multilevel TTTGTTTT consensus CA C C sequence C G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTYVTTTY MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr10:73529001-73529021 12 1.31e-05 ctttttaaat tttatttt a chr13:41886077-41886097 8 1.31e-05 CCGGTGG TTTATTTT GCCAG chr1:38391891-38391911 1 3.90e-05 . TTTGTTTC CTGGGTCCAG chr9:102669161-102669181 4 3.90e-05 GGT TTCGTTTT TGGAAGCTT chr6:21004268-21004288 6 4.78e-05 AAATA TTTGTGTT ATGAGTT chrX:1408625-1408645 11 4.78e-05 gtggttttct tttgtgtt tg chr10:99408665-99408685 8 5.69e-05 AAGTTAG TTTGTCTT TAAGA chr6:143268903-143268923 12 1.59e-04 TGCGGAATGT TTTGTGTC T chr10:112116860-11211688 2 1.59e-04 G TTCGTGTT TCTGTGAGAC chr9:31347119-31347139 7 1.59e-04 TATATT TTTCTCTT TTGATA chr1:25074988-25075008 13 1.89e-04 tttttttttt tttttttt chr7:130598028-130598048 1 1.98e-04 . TTCATTTC TGGAAGTGAT chr14:55094721-55094741 11 1.98e-04 CATATCAAGA TTCATTTC TG chr19:7242907-7242927 10 2.58e-04 AAGCAGTAC TCTGTTTT CAG chr14:72022186-72022206 9 3.20e-04 tgatcttc tttctctc caga chr11:128480797-12848081 1 4.84e-04 . TTCCTCTC AGACCCAGAC chr2:149372194-149372214 6 5.95e-04 TCTTC TCCCTTTT ACCTGAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTYVTTTY MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr10:73529001-73529021 1.3e-05 11_[+1]_1 chr13:41886077-41886097 1.3e-05 7_[+1]_5 chr1:38391891-38391911 3.9e-05 [+1]_12 chr9:102669161-102669181 3.9e-05 3_[+1]_9 chr6:21004268-21004288 4.8e-05 5_[+1]_7 chrX:1408625-1408645 4.8e-05 10_[+1]_2 chr10:99408665-99408685 5.7e-05 7_[+1]_5 chr6:143268903-143268923 0.00016 11_[+1]_1 chr10:112116860-11211688 0.00016 1_[+1]_11 chr9:31347119-31347139 0.00016 6_[+1]_6 chr1:25074988-25075008 0.00019 12_[+1] chr7:130598028-130598048 0.0002 [+1]_12 chr14:55094721-55094741 0.0002 10_[+1]_2 chr19:7242907-7242927 0.00026 9_[+1]_3 chr14:72022186-72022206 0.00032 8_[+1]_4 chr11:128480797-12848081 0.00048 [+1]_12 chr2:149372194-149372214 0.00059 5_[+1]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTYVTTTY MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTYVTTTY width=8 seqs=17 chr10:73529001-73529021 ( 12) TTTATTTT 1 chr13:41886077-41886097 ( 8) TTTATTTT 1 chr1:38391891-38391911 ( 1) TTTGTTTC 1 chr9:102669161-102669181 ( 4) TTCGTTTT 1 chr6:21004268-21004288 ( 6) TTTGTGTT 1 chrX:1408625-1408645 ( 11) TTTGTGTT 1 chr10:99408665-99408685 ( 8) TTTGTCTT 1 chr6:143268903-143268923 ( 12) TTTGTGTC 1 chr10:112116860-11211688 ( 2) TTCGTGTT 1 chr9:31347119-31347139 ( 7) TTTCTCTT 1 chr1:25074988-25075008 ( 13) TTTTTTTT 1 chr7:130598028-130598048 ( 1) TTCATTTC 1 chr14:55094721-55094741 ( 11) TTCATTTC 1 chr19:7242907-7242927 ( 10) TCTGTTTT 1 chr14:72022186-72022206 ( 9) TTTCTCTC 1 chr11:128480797-12848081 ( 1) TTCCTCTC 1 chr2:149372194-149372214 ( 6) TCCCTTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTYVTTTY MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.34207 E= 3.4e+001 -1073 -1073 -1073 217 -1073 -127 -1073 199 -1073 31 -1073 154 7 -27 80 -191 -1073 -1073 -1073 217 -1073 -27 -20 125 -1073 -1073 -1073 217 -1073 31 -1073 154 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTYVTTTY MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 17 E= 3.4e+001 0.000000 0.000000 0.000000 1.000000 0.000000 0.117647 0.000000 0.882353 0.000000 0.352941 0.000000 0.647059 0.235294 0.235294 0.470588 0.058824 0.000000 0.000000 0.000000 1.000000 0.000000 0.235294 0.235294 0.529412 0.000000 0.000000 0.000000 1.000000 0.000000 0.352941 0.000000 0.647059 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTYVTTTY MEME-1 regular expression -------------------------------------------------------------------------------- TT[TC][GAC]T[TCG]T[TC] -------------------------------------------------------------------------------- Time 3.14 secs. ******************************************************************************** ******************************************************************************** MOTIF GATTACAG MEME-2 width = 8 sites = 4 llr = 43 E-value = 1.3e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif GATTACAG MEME-2 Description -------------------------------------------------------------------------------- Simplified A :a::8:a: pos.-specific C :::::a:: probability G a::::::a matrix T ::aa3::: bits 2.2 *** * 2.0 **** ** 1.7 **** *** 1.5 **** *** Relative 1.3 ******** Entropy 1.1 ******** (15.6 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GATTACAG consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATTACAG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr17:65809279-65809299 8 1.15e-05 aggccag gattacag gtgtg chr5:176839879-176839899 1 1.15e-05 . gattacag gttcatgcca chr17:47647206-47647226 6 1.15e-05 gctgg gattacag gcgcgcg chr10:76499079-76499099 8 2.28e-05 ccacctt gatttcag cattt -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATTACAG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr17:65809279-65809299 1.1e-05 7_[+2]_5 chr5:176839879-176839899 1.1e-05 [+2]_12 chr17:47647206-47647226 1.1e-05 5_[+2]_7 chr10:76499079-76499099 2.3e-05 7_[+2]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATTACAG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GATTACAG width=8 seqs=4 chr17:65809279-65809299 ( 8) GATTACAG 1 chr5:176839879-176839899 ( 1) GATTACAG 1 chr17:47647206-47647226 ( 6) GATTACAG 1 chr10:76499079-76499099 ( 8) GATTTCAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATTACAG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.66445 E= 1.3e+003 -865 -865 189 -865 216 -865 -865 -865 -865 -865 -865 217 -865 -865 -865 217 174 -865 -865 17 -865 181 -865 -865 216 -865 -865 -865 -865 -865 189 -865 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATTACAG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 1.3e+003 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.750000 0.000000 0.000000 0.250000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GATTACAG MEME-2 regular expression -------------------------------------------------------------------------------- GATT[AT]CAG -------------------------------------------------------------------------------- Time 3.93 secs. ******************************************************************************** ******************************************************************************** MOTIF ATACAAAA MEME-3 width = 8 sites = 2 llr = 23 E-value = 7.2e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif ATACAAAA MEME-3 Description -------------------------------------------------------------------------------- Simplified A a:a:aaaa pos.-specific C :::a:::: probability G :::::::: matrix T :a:::::: bits 2.2 *** **** 2.0 *** **** 1.7 ******** 1.5 ******** Relative 1.3 ******** Entropy 1.1 ******** (16.9 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel ATACAAAA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATACAAAA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr16:68790739-68790759 5 7.96e-06 ctac atacaaaa acaattac chr17:59981845-59981865 3 7.96e-06 GC ATACAAAA GGAAAGTGAA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATACAAAA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr16:68790739-68790759 8e-06 4_[+3]_8 chr17:59981845-59981865 8e-06 2_[+3]_10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATACAAAA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ATACAAAA width=8 seqs=2 chr16:68790739-68790759 ( 5) ATACAAAA 1 chr17:59981845-59981865 ( 3) ATACAAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATACAAAA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.81663 E= 7.2e+003 215 -765 -765 -765 -765 -765 -765 217 215 -765 -765 -765 -765 181 -765 -765 215 -765 -765 -765 215 -765 -765 -765 215 -765 -765 -765 215 -765 -765 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATACAAAA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 7.2e+003 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATACAAAA MEME-3 regular expression -------------------------------------------------------------------------------- ATACAAAA -------------------------------------------------------------------------------- Time 4.84 secs. ******************************************************************************** ******************************************************************************** MOTIF AGGCWGGV MEME-4 width = 8 sites = 9 llr = 79 E-value = 2.1e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif AGGCWGGV MEME-4 Description -------------------------------------------------------------------------------- Simplified A a::14::2 pos.-specific C :::9:::3 probability G :aa::aa4 matrix T ::::6::: bits 2.2 * 2.0 *** ** 1.7 *** ** 1.5 *** ** Relative 1.3 **** ** Entropy 1.1 ******* (12.6 bits) 0.9 ******* 0.7 ******* 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AGGCTGGG consensus A C sequence A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCWGGV MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr8:132916655-132916675 3 2.03e-05 GG AGGCTGGG CCGCGCTGAG chr2:172750651-172750671 2 4.07e-05 C AGGCAGGG CGCTCGGAAT chr10:101492101-10149212 11 4.07e-05 GAGCATGAAA AGGCAGGG GG chr5:96143659-96143679 7 6.20e-05 AGCGGC AGGCTGGC GCTGAG chr11:121163772-12116379 6 6.20e-05 AGGAG AGGCTGGC AGGTAGC chr17:55082551-55082571 8 7.88e-05 ctcaaaa aggctgga attgt chr3:49481788-49481808 6 7.88e-05 tcccc aggctgga gtgcagt chr5:88185322-88185342 13 1.00e-04 GGCGAGCAGG AGGCAGGC chr9:19184290-19184310 2 1.49e-04 G AGGAAGGG AAAAAAAAAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCWGGV MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr8:132916655-132916675 2e-05 2_[+4]_10 chr2:172750651-172750671 4.1e-05 1_[+4]_11 chr10:101492101-10149212 4.1e-05 10_[+4]_2 chr5:96143659-96143679 6.2e-05 6_[+4]_6 chr11:121163772-12116379 6.2e-05 5_[+4]_7 chr17:55082551-55082571 7.9e-05 7_[+4]_5 chr3:49481788-49481808 7.9e-05 5_[+4]_7 chr5:88185322-88185342 0.0001 12_[+4] chr9:19184290-19184310 0.00015 1_[+4]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCWGGV MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AGGCWGGV width=8 seqs=9 chr8:132916655-132916675 ( 3) AGGCTGGG 1 chr2:172750651-172750671 ( 2) AGGCAGGG 1 chr10:101492101-10149212 ( 11) AGGCAGGG 1 chr5:96143659-96143679 ( 7) AGGCTGGC 1 chr11:121163772-12116379 ( 6) AGGCTGGC 1 chr17:55082551-55082571 ( 8) AGGCTGGA 1 chr3:49481788-49481808 ( 6) AGGCTGGA 1 chr5:88185322-88185342 ( 13) AGGCAGGC 1 chr9:19184290-19184310 ( 2) AGGAAGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCWGGV MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.62696 E= 2.1e+003 216 -982 -982 -982 -982 -982 189 -982 -982 -982 189 -982 -101 164 -982 -982 99 -982 -982 132 -982 -982 189 -982 -982 -982 189 -982 -1 23 72 -982 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCWGGV MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 9 E= 2.1e+003 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.111111 0.888889 0.000000 0.000000 0.444444 0.000000 0.000000 0.555556 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.222222 0.333333 0.444444 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGCWGGV MEME-4 regular expression -------------------------------------------------------------------------------- AGGC[TA]GG[GCA] -------------------------------------------------------------------------------- Time 5.97 secs. ******************************************************************************** ******************************************************************************** MOTIF TTKTTTTG MEME-5 width = 8 sites = 2 llr = 22 E-value = 4.4e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif TTKTTTTG MEME-5 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C :::::::: probability G ::5::::a matrix T aa5aaaa: bits 2.2 ** **** 2.0 ** ***** 1.7 ** ***** 1.5 ** ***** Relative 1.3 ** ***** Entropy 1.1 ******** (16.0 bits) 0.9 ******** 0.7 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TTGTTTTG consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTKTTTTG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr3:101232214-101232234 6 7.18e-06 CAGCG TTTTTTTG GTGGCGT chr16:3676522-3676542 1 1.59e-05 . ttgttttg tgacttttat -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTKTTTTG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr3:101232214-101232234 7.2e-06 5_[+5]_7 chr16:3676522-3676542 1.6e-05 [+5]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTKTTTTG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TTKTTTTG width=8 seqs=2 chr3:101232214-101232234 ( 6) TTTTTTTG 1 chr16:3676522-3676542 ( 1) TTGTTTTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTKTTTTG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.81663 E= 4.4e+003 -765 -765 -765 217 -765 -765 -765 217 -765 -765 89 117 -765 -765 -765 217 -765 -765 -765 217 -765 -765 -765 217 -765 -765 -765 217 -765 -765 188 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTKTTTTG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 4.4e+003 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.500000 0.500000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TTKTTTTG MEME-5 regular expression -------------------------------------------------------------------------------- TT[GT]TTTTG -------------------------------------------------------------------------------- Time 6.75 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr6:106960469-106960489 9.78e-01 20 chr5:64778805-64778825 7.47e-02 20 chr12:83080450-83080470 3.07e-01 20 chr10:91174378-91174398 7.04e-01 20 chrX:1408625-1408645 1.78e-04 5_[+1(2.07e-05)]_7 chr9:31347119-31347139 1.43e-02 20 chr9:69786651-69786671 9.95e-01 20 chr10:17601654-17601674 9.39e-01 20 chr4:169401553-169401573 9.86e-01 20 chr1:111329832-111329852 7.04e-02 20 chr1:47082291-47082311 5.99e-01 20 chr20:42285498-42285518 3.23e-02 1_[+3(2.80e-05)]_11 chr18:24559067-24559087 1.98e-01 20 chr18:9095618-9095638 8.21e-01 20 chr8:67026146-67026166 1.10e-01 20 chrX:44732757-44732777 9.10e-01 20 chr13:22636251-22636271 9.44e-01 20 chr10:6019593-6019613 8.57e-01 20 chr16:3676522-3676542 5.33e-03 [+5(1.59e-05)]_12 chr19:7242907-7242927 4.72e-04 20 chr2:101197633-101197653 2.37e-01 20 chr22:18632781-18632801 5.33e-01 20 chr2:152118205-152118225 9.75e-01 20 chr3:143248251-143248271 6.77e-01 20 chr12:104888418-10488843 8.17e-01 20 chr17:59981845-59981865 7.31e-03 2_[+3(7.96e-06)]_10 chr17:53046447-53046467 1.21e-01 20 chr11:6767864-6767884 8.48e-01 20 chr4:147096985-147097005 6.18e-01 20 chr21:40556052-40556072 9.26e-01 20 chr9:102669161-102669181 6.44e-03 3_[+1(3.90e-05)]_9 chr6:26322625-26322645 1.85e-01 20 chr6:101329009-101329029 5.36e-01 20 chr14:20811097-20811117 6.56e-01 20 chr12:12849451-12849471 7.10e-01 20 chr3:31574505-31574525 7.78e-01 20 chr1:59434293-59434313 5.29e-01 20 chr5:131439361-131439381 8.28e-01 20 chr7:148638233-148638253 6.83e-01 20 chr10:99408665-99408685 1.41e-03 7_[+1(5.69e-05)]_5 chr3:105088230-105088250 9.36e-01 20 chr1:158978570-158978590 7.11e-01 20 chr16:84674797-84674817 9.47e-01 20 chr2:133023539-133023559 3.54e-01 20 chr10:90734965-90734985 4.85e-01 20 chr3:113251410-113251430 2.35e-01 20 chr1:21503277-21503297 8.71e-01 20 chr20:61282927-61282947 3.67e-01 20 chr3:197121339-197121359 5.24e-01 20 chr4:156874963-156874983 8.74e-01 20 chr6:28696938-28696958 8.19e-01 20 chr11:93862210-93862230 9.27e-01 20 chr10:45957854-45957874 9.38e-01 20 chr11:58910398-58910418 3.68e-01 20 chr10:92980569-92980589 9.90e-01 20 chr14:35099033-35099053 9.01e-01 20 chr10:23304273-23304293 1.02e-01 20 chr17:47647206-47647226 7.35e-03 5_[+2(1.15e-05)]_7 chr1:175111392-175111412 5.61e-01 20 chr15:70489330-70489350 9.36e-01 20 chr6:111803569-111803589 9.28e-01 20 chr3:101395688-101395708 6.08e-01 20 chr14:60559123-60559143 4.06e-01 20 chr9:123834094-123834114 8.10e-01 20 chr10:76499079-76499099 6.05e-04 7_[+2(2.28e-05)]_5 chr10:5726892-5726912 4.67e-01 20 chr4:177241246-177241266 7.19e-01 20 chr14:55094721-55094741 1.88e-03 20 chr5:176839879-176839899 7.67e-03 [+2(1.15e-05)]_12 chr6:52356290-52356310 8.31e-01 20 chr13:41886077-41886097 1.62e-04 7_[+1(1.31e-05)]_5 chr1:35734573-35734593 8.58e-01 20 chr16:71850985-71851005 8.52e-01 20 chr5:180634148-180634168 5.80e-01 20 chr9:69786918-69786938 8.37e-01 20 chr6:27661932-27661952 9.32e-01 20 chr6:28863695-28863715 5.77e-01 20 chr18:31280705-31280725 3.76e-01 20 chr4:170533499-170533519 9.24e-01 20 chr7:148660128-148660148 3.36e-01 20 chr6:121655976-121655996 7.69e-01 20 chr14:72022186-72022206 6.56e-02 20 chr4:47487467-47487487 2.79e-02 20 chr6:126101661-126101681 9.09e-01 20 chr2:133026772-133026792 9.89e-01 20 chr13:42614458-42614478 6.74e-01 20 chr6:126101877-126101897 7.12e-01 20 chr13:76124036-76124056 8.86e-01 20 chr16:68790739-68790759 3.73e-02 4_[+3(7.96e-06)]_8 chr11:121163772-12116379 6.06e-02 5_[+4(6.20e-05)]_7 chr5:88030965-88030985 7.76e-01 20 chr9:100881384-100881404 8.95e-01 20 chr12:12849711-12849731 2.45e-01 20 chr1:143539797-143539817 2.35e-01 20 chr5:96212226-96212246 9.46e-01 20 chr5:49963814-49963834 9.61e-01 20 chr15:45459419-45459439 2.77e-01 20 chr1:22192613-22192633 3.18e-01 20 chr11:109827255-10982727 9.98e-01 20 chr5:124316348-124316368 7.45e-01 20 chr11:86792572-86792592 1.66e-01 20 chr11:102345337-10234535 4.21e-01 20 chr19:4214728-4214748 7.11e-01 20 chr2:201753440-201753460 6.13e-01 20 chr10:112116860-11211688 2.02e-02 20 chr13:41634215-41634235 9.08e-01 20 chr7:130598028-130598048 4.51e-03 20 chr2:179343254-179343274 9.95e-01 20 chr12:102271177-10227119 9.96e-01 20 chr6:21004268-21004288 8.06e-03 5_[+1(4.78e-05)]_7 chr3:101232214-101232234 2.97e-03 5_[+5(7.18e-06)]_7 chr10:73529001-73529021 4.47e-04 11_[+1(1.31e-05)]_1 chr6:42742817-42742837 9.98e-01 20 chr13:98628993-98629013 9.94e-01 20 chr8:38854722-38854742 9.21e-01 20 chr2:7049895-7049915 2.28e-01 20 chr19:39921997-39922017 5.80e-01 20 chr1:32538653-32538673 9.02e-01 20 chr3:37218007-37218027 3.07e-01 20 chr4:128802240-128802260 8.86e-01 20 chr5:88185322-88185342 1.70e-01 20 chr13:26760487-26760507 7.16e-01 20 chr20:43280932-43280952 4.92e-01 20 chr21:37661442-37661462 2.45e-01 20 chr2:149372194-149372214 1.73e-01 20 chr17:34418185-34418205 3.15e-01 20 chr6:14075494-14075514 8.95e-01 20 chr2:30670209-30670229 9.99e-01 20 chr2:136289269-136289289 9.98e-01 20 chr17:53046238-53046258 4.74e-01 20 chr11:43380826-43380846 9.10e-01 20 chr4:48782059-48782079 6.66e-01 20 chr1:87380748-87380768 6.16e-01 20 chr12:110517657-11051767 3.16e-01 20 chr14:64702648-64702668 9.99e-01 20 chr2:179343456-179343476 7.44e-01 20 chr2:175357802-175357822 1.84e-01 20 chr2:48667658-48667678 3.75e-01 20 chr6:33239998-33240018 1.22e-01 20 chr9:20623499-20623519 8.05e-01 20 chr6:27144931-27144951 6.36e-01 20 chr4:47487709-47487729 6.32e-01 20 chr6:20402250-20402270 8.32e-01 20 chr5:54048883-54048903 4.30e-01 20 chr12:111842618-11184263 5.49e-02 20 chr1:25074988-25075008 2.58e-03 2_[+5(5.17e-05)]_[+5(5.17e-05)]_2 chr9:19184290-19184310 1.20e-02 20 chr1:87523655-87523675 5.24e-01 20 chr12:40013603-40013623 3.62e-01 20 chr6:57385697-57385717 5.50e-02 20 chr16:14379536-14379556 4.09e-01 20 chr5:131746630-131746650 9.14e-01 20 chr1:230259439-230259459 1.92e-01 20 chr2:191224872-191224892 7.95e-01 20 chr4:120988215-120988235 3.58e-02 20 chr15:49087343-49087363 1.94e-01 20 chr10:38265215-38265235 1.00e+00 20 chr9:127951821-127951841 8.65e-01 20 chrX:15808481-15808501 7.89e-01 20 chr8:82066279-82066299 2.07e-01 20 chr10:120938150-12093817 4.59e-01 20 chr4:103997576-103997596 1.00e+00 20 chr3:49481788-49481808 1.40e-02 5_[+4(7.88e-05)]_7 chr10:5727232-5727252 8.66e-01 20 chr1:94312288-94312308 9.99e-01 20 chr5:155829651-155829671 4.51e-02 20 chr5:95096443-95096463 5.18e-01 20 chr16:70438539-70438559 6.84e-01 20 chr5:96143659-96143679 1.33e-01 6_[+4(6.20e-05)]_6 chr1:35658151-35658171 9.42e-01 20 chr13:48575259-48575279 3.62e-01 20 chr12:95611102-95611122 9.48e-01 20 chr1:75198933-75198953 2.43e-01 20 chr9:6750642-6750662 5.34e-01 20 chr14:97264089-97264109 9.38e-01 20 chr1:117910084-117910104 9.97e-01 20 chr2:54198262-54198282 8.02e-01 20 chr6:21589061-21589081 4.75e-01 20 chr20:50808016-50808036 2.25e-01 20 chr6:143268903-143268923 3.48e-03 20 chr8:124286525-124286545 6.95e-01 20 chr1:200597368-200597388 6.82e-01 20 chr10:101492101-10149212 1.92e-02 10_[+4(4.07e-05)]_2 chr2:149402346-149402366 9.10e-01 20 chr14:75651504-75651524 9.81e-01 20 chr6:42847797-42847817 7.52e-02 20 chr15:77197561-77197581 3.04e-01 20 chr15:99789566-99789586 6.75e-01 20 chr17:63053259-63053279 9.88e-01 20 chr17:1101707-1101727 9.82e-01 20 chr13:24463195-24463215 2.17e-01 20 chr14:53575976-53575996 5.62e-01 20 chr12:68768416-68768436 2.23e-01 20 chr10:103949440-10394946 8.59e-01 20 chr15:52263917-52263937 8.17e-01 20 chr8:124169720-124169740 9.69e-01 20 chr11:62341198-62341218 9.49e-01 20 chr8:33412334-33412354 1.48e-01 20 chr13:53024437-53024457 1.00e+00 20 chr4:75072569-75072589 1.09e-01 20 chr17:4607332-4607352 9.98e-01 20 chr6:136611634-136611654 2.52e-01 20 chr19:14480962-14480982 6.25e-01 20 chr10:90145993-90146013 4.72e-01 20 chr22:34292885-34292905 9.99e-01 20 chr2:172750651-172750671 1.02e-01 1_[+4(4.07e-05)]_11 chr6:116730885-116730905 6.78e-01 20 chr1:84543688-84543708 9.37e-01 20 chr1:40619164-40619184 4.71e-01 20 chr3:12882888-12882908 7.74e-01 20 chr3:48956003-48956023 6.61e-01 20 chr11:128480797-12848081 1.14e-01 20 chr1:38391891-38391911 5.55e-04 [+1(3.90e-05)]_12 chr6:34393773-34393793 8.41e-01 20 chr11:82904586-82904606 5.70e-01 20 chr17:65809279-65809299 6.31e-03 7_[+2(1.15e-05)]_5 chr13:76336696-76336716 4.04e-01 20 chr3:108308397-108308417 9.04e-01 20 chr20:5626412-5626432 3.98e-01 20 chr10:82231992-82232012 4.89e-01 20 chr6:88411824-88411844 9.79e-01 20 chr3:197677235-197677255 4.34e-01 20 chr17:55082551-55082571 2.25e-02 7_[+4(7.88e-05)]_5 chr6:106440266-106440286 3.22e-01 20 chr10:25189970-25189990 5.46e-01 20 chr11:104839214-10483923 7.42e-01 20 chr2:67624505-67624525 5.99e-01 20 chr14:100706077-10070609 8.26e-01 20 chr6:28831672-28831692 1.77e-01 20 chr14:91790345-91790365 7.24e-01 20 chr4:83821561-83821581 5.52e-01 20 chr11:46143554-46143574 9.24e-01 20 chr14:65879908-65879928 9.79e-01 20 chr15:29562298-29562318 1.22e-01 20 chr20:29650766-29650786 2.45e-01 20 chr6:27573016-27573036 8.26e-01 20 chr12:113623096-11362311 3.75e-01 20 chr11:31531445-31531465 9.25e-01 20 chr20:37591120-37591140 9.89e-01 20 chr14:52313970-52313990 7.06e-01 20 chr9:20604929-20604949 3.94e-01 20 chr3:156202382-156202402 8.81e-01 20 chr8:132916655-132916675 7.83e-02 2_[+4(2.03e-05)]_10 chr2:191399337-191399357 8.24e-01 20 chr18:5975085-5975105 9.91e-01 20 chr17:38804246-38804266 9.92e-01 20 chr17:59940758-59940778 8.51e-01 20 chr8:91658258-91658278 9.22e-01 20 chr3:148804205-148804225 7.85e-01 20 chr16:14702146-14702166 2.39e-01 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n04.farnam.hpc.yale.internal ********************************************************************************