******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/EZH2.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr2:91670156-91670176 1.0000 20 chr8:123685724-123685744 1.0000 20 chr5:141256860-141256880 1.0000 20 chr7:49814487-49814507 1.0000 20 chr7:5465233-5465253 1.0000 20 chr6:91004574-91004594 1.0000 20 chr1:145040789-145040809 1.0000 20 chr12:54403282-54403302 1.0000 20 chr9:98784671-98784691 1.0000 20 chr5:52774424-52774444 1.0000 20 chr7:129423426-129423446 1.0000 20 chr17:77773576-77773596 1.0000 20 chr1:155054081-155054101 1.0000 20 chr11:128555978-12855599 1.0000 20 chr12:2162517-2162537 1.0000 20 chr2:54951567-54951587 1.0000 20 chr9:133541002-133541022 1.0000 20 chr1:47696677-47696697 1.0000 20 chr2:19561984-19562004 1.0000 20 chr11:31822098-31822118 1.0000 20 chr6:75916150-75916170 1.0000 20 chr3:169378788-169378808 1.0000 20 chr5:115297772-115297792 1.0000 20 chr17:77816794-77816814 1.0000 20 chr2:121453377-121453397 1.0000 20 chr12:47473131-47473151 1.0000 20 chr4:42398516-42398536 1.0000 20 chr5:92948057-92948077 1.0000 20 chr6:13925786-13925806 1.0000 20 chr10:102414263-10241428 1.0000 20 chr10:126138990-12613901 1.0000 20 chr17:37756031-37756051 1.0000 20 chr15:66545360-66545380 1.0000 20 chr18:56939501-56939521 1.0000 20 chr6:10419164-10419184 1.0000 20 chr5:92943662-92943682 1.0000 20 chr7:2560348-2560368 1.0000 20 chr4:121844461-121844481 1.0000 20 chr7:120629054-120629074 1.0000 20 chr1:6301539-6301559 1.0000 20 chr15:40211380-40211400 1.0000 20 chr2:175208224-175208244 1.0000 20 chr4:118955214-118955234 1.0000 20 chr3:128209108-128209128 1.0000 20 chr1:50887498-50887518 1.0000 20 chr3:181442009-181442029 1.0000 20 chr19:18722125-18722145 1.0000 20 chr9:14313649-14313669 1.0000 20 chr4:75859686-75859706 1.0000 20 chr12:96185298-96185318 1.0000 20 chr9:126772283-126772303 1.0000 20 chr1:44872079-44872099 1.0000 20 chr4:140478659-140478679 1.0000 20 chr13:51797079-51797099 1.0000 20 chr11:71951565-71951585 1.0000 20 chr9:100610576-100610596 1.0000 20 chr7:29604252-29604272 1.0000 20 chr13:79178266-79178286 1.0000 20 chr5:52775324-52775344 1.0000 20 chr6:106442618-106442638 1.0000 20 chr20:2781737-2781757 1.0000 20 chr17:47073883-47073903 1.0000 20 chr12:62586539-62586559 1.0000 20 chr1:156893171-156893191 1.0000 20 chr17:37762349-37762369 1.0000 20 chr10:102500540-10250056 1.0000 20 chr12:48397716-48397736 1.0000 20 chr1:47696146-47696166 1.0000 20 chr6:5994506-5994526 1.0000 20 chr12:54404234-54404254 1.0000 20 chr1:218339114-218339134 1.0000 20 chr22:46374052-46374072 1.0000 20 chr10:71562010-71562030 1.0000 20 chr1:201507973-201507993 1.0000 20 chr21:34444256-34444276 1.0000 20 chr12:54321187-54321207 1.0000 20 chr5:87968253-87968273 1.0000 20 chr2:219846063-219846083 1.0000 20 chr5:153855671-153855691 1.0000 20 chr11:31834273-31834293 1.0000 20 chr8:76319156-76319176 1.0000 20 chr7:25891725-25891745 1.0000 20 chr9:135037859-135037879 1.0000 20 chr14:65170617-65170637 1.0000 20 chr18:55468848-55468868 1.0000 20 chr12:54089670-54089690 1.0000 20 chr10:22626161-22626181 1.0000 20 chr18:19749941-19749961 1.0000 20 chr14:69726125-69726145 1.0000 20 chr17:30592318-30592338 1.0000 20 chr22:19747867-19747887 1.0000 20 chr17:77788245-77788265 1.0000 20 chr5:180480718-180480738 1.0000 20 chr1:156595615-156595635 1.0000 20 chr2:111875122-111875142 1.0000 20 chr2:157177856-157177876 1.0000 20 chr1:93914652-93914672 1.0000 20 chr4:78979860-78979880 1.0000 20 chr10:102986342-10298636 1.0000 20 chr1:107683606-107683626 1.0000 20 chr3:187456029-187456049 1.0000 20 chr1:119522151-119522171 1.0000 20 chr11:130299179-13029919 1.0000 20 chr1:68297777-68297797 1.0000 20 chr11:75379519-75379539 1.0000 20 chr22:44728101-44728121 1.0000 20 chr7:5462562-5462582 1.0000 20 chr8:37554901-37554921 1.0000 20 chr6:45982677-45982697 1.0000 20 chr4:186455870-186455890 1.0000 20 chr8:57069557-57069577 1.0000 20 chr10:102586998-10258701 1.0000 20 chr6:126072676-126072696 1.0000 20 chr13:100637015-10063703 1.0000 20 chr11:125036748-12503676 1.0000 20 chr11:12697759-12697779 1.0000 20 chr8:21646249-21646269 1.0000 20 chr5:92921117-92921137 1.0000 20 chr11:10953300-10953320 1.0000 20 chr12:103355634-10335565 1.0000 20 chr13:107185928-10718594 1.0000 20 chr1:29563455-29563475 1.0000 20 chr6:143999687-143999707 1.0000 20 chr5:92947476-92947496 1.0000 20 chr6:126069829-126069849 1.0000 20 chr9:107690146-107690166 1.0000 20 chr11:10952291-10952311 1.0000 20 chr1:227505388-227505408 1.0000 20 chr10:102588409-10258842 1.0000 20 chr2:45167469-45167489 1.0000 20 chr7:126892060-126892080 1.0000 20 chr6:41341518-41341538 1.0000 20 chr2:171569393-171569413 1.0000 20 chr17:36729508-36729528 1.0000 20 chr2:207309186-207309206 1.0000 20 chr6:10396042-10396062 1.0000 20 chr2:111875960-111875980 1.0000 20 chr3:35681975-35681995 1.0000 20 chr3:138662768-138662788 1.0000 20 chr3:122747372-122747392 1.0000 20 chr1:145039547-145039567 1.0000 20 chr17:46827654-46827674 1.0000 20 chr17:54673727-54673747 1.0000 20 chr2:175869313-175869333 1.0000 20 chr1:18956773-18956793 1.0000 20 chr17:47574350-47574370 1.0000 20 chr3:18486105-18486125 1.0000 20 chr7:28220680-28220700 1.0000 20 chr2:193060893-193060913 1.0000 20 chr15:68870417-68870437 1.0000 20 chr8:70946710-70946730 1.0000 20 chr11:10316732-10316752 1.0000 20 chr1:197881711-197881731 1.0000 20 chr9:124981492-124981512 1.0000 20 chr8:20160632-20160652 1.0000 20 chr2:63275277-63275297 1.0000 20 chr15:53097193-53097213 1.0000 20 chr3:71630429-71630449 1.0000 20 chr6:127440348-127440368 1.0000 20 chr6:144608277-144608297 1.0000 20 chr22:17851006-17851026 1.0000 20 chr1:63793235-63793255 1.0000 20 chr1:245318575-245318595 1.0000 20 chr1:20812589-20812609 1.0000 20 chr1:46957412-46957432 1.0000 20 chrX:71525879-71525899 1.0000 20 chr10:62702951-62702971 1.0000 20 chr2:74726100-74726120 1.0000 20 chr11:16626373-16626393 1.0000 20 chr11:64065227-64065247 1.0000 20 chr9:126782651-126782671 1.0000 20 chr7:43151784-43151804 1.0000 20 chr1:197885934-197885954 1.0000 20 chr6:137813610-137813630 1.0000 20 chr14:103389634-10338965 1.0000 20 chr2:119594309-119594329 1.0000 20 chr2:85980411-85980431 1.0000 20 chr2:66802370-66802390 1.0000 20 chr7:150863845-150863865 1.0000 20 chr1:210407928-210407948 1.0000 20 chr2:111876939-111876959 1.0000 20 chr7:1277516-1277536 1.0000 20 chr17:56834421-56834441 1.0000 20 chr12:52400186-52400206 1.0000 20 chr1:10855455-10855475 1.0000 20 chr12:54423819-54423839 1.0000 20 chr12:26112391-26112411 1.0000 20 chr17:36102523-36102543 1.0000 20 chr12:54427514-54427534 1.0000 20 chr1:29564703-29564723 1.0000 20 chr6:91005485-91005505 1.0000 20 chr21:34443438-34443458 1.0000 20 chr2:102091542-102091562 1.0000 20 chr2:119591922-119591942 1.0000 20 chr12:116713854-11671387 1.0000 20 chr2:73147386-73147406 1.0000 20 chr10:73157176-73157196 1.0000 20 chr1:23544441-23544461 1.0000 20 chr2:190446153-190446173 1.0000 20 chr14:33409618-33409638 1.0000 20 chr1:64239246-64239266 1.0000 20 chr11:46939562-46939582 1.0000 20 chr10:101294305-10129432 1.0000 20 chr1:61548229-61548249 1.0000 20 chr6:138427943-138427963 1.0000 20 chr17:36730286-36730306 1.0000 20 chr2:74727477-74727497 1.0000 20 chr11:124712340-12471236 1.0000 20 chr6:10414854-10414874 1.0000 20 chr7:155258708-155258728 1.0000 20 chr4:55093298-55093318 1.0000 20 chr10:126069752-12606977 1.0000 20 chr17:59530160-59530180 1.0000 20 chr20:30457750-30457770 1.0000 20 chr18:10455379-10455399 1.0000 20 chr1:18958793-18958813 1.0000 20 chr4:175443993-175444013 1.0000 20 chr2:70995196-70995216 1.0000 20 chr7:103630908-103630928 1.0000 20 chr6:43212651-43212671 1.0000 20 chr7:155167568-155167588 1.0000 20 chr2:175203902-175203922 1.0000 20 chr17:35290350-35290370 1.0000 20 chr3:55517426-55517446 1.0000 20 chr7:1279585-1279605 1.0000 20 chr2:60788254-60788274 1.0000 20 chr5:128796684-128796704 1.0000 20 chr18:53255755-53255775 1.0000 20 chr8:77593888-77593908 1.0000 20 chr15:68116622-68116642 1.0000 20 chr2:17719736-17719756 1.0000 20 chr15:73343534-73343554 1.0000 20 chr2:162283321-162283341 1.0000 20 chr17:6459099-6459119 1.0000 20 chr12:54388832-54388852 1.0000 20 chr15:65668557-65668577 1.0000 20 chr12:54360822-54360842 1.0000 20 chr13:114462628-11446264 1.0000 20 chr2:219849506-219849526 1.0000 20 chr17:79368703-79368723 1.0000 20 chr7:49815983-49816003 1.0000 20 chr3:157821698-157821718 1.0000 20 chr2:175195108-175195128 1.0000 20 chr4:55093780-55093800 1.0000 20 chr5:76940041-76940061 1.0000 20 chr8:144511086-144511106 1.0000 20 chr2:46523867-46523887 1.0000 20 chr6:21666835-21666855 1.0000 20 chr16:2077635-2077655 1.0000 20 chr6:100913605-100913625 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_EZH2/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/EZH2.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.251 C 0.256 G 0.246 T 0.248 Background letter frequencies (from file dataset with add-one prior applied): A 0.251 C 0.256 G 0.246 T 0.248 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF AGGGAGAG MEME-1 width = 8 sites = 12 llr = 103 E-value = 1.3e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif AGGGAGAG MEME-1 Description -------------------------------------------------------------------------------- Simplified A 6:::a38: pos.-specific C 2::2:::: probability G 1aa8:82a matrix T 2::::::: bits 2.0 ** * * 1.8 ** * * 1.6 ** * * 1.4 **** ** Relative 1.2 ******* Entropy 1.0 ******* (12.4 bits) 0.8 ******* 0.6 ******* 0.4 ******** 0.2 ******** 0.0 -------- Multilevel AGGGAGAG consensus A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGAGAG MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr11:10953300-10953320 13 1.42e-05 atggacccgg agggagag chr5:52774424-52774444 2 1.42e-05 g agggagag tacgggtaga chr1:20812589-20812609 3 2.88e-05 gg agggaaag gatcgggagg chr2:45167469-45167489 2 2.88e-05 C AGGGAAAG ACGTCTCTGA chr21:34443438-34443458 9 4.29e-05 CCTGCGTC TGGGAGAG CGAG chr17:37756031-37756051 6 4.29e-05 GAAGC TGGGAGAG AGGTTTA chr1:18958793-18958813 9 5.74e-05 AAATCTCC CGGGAGAG AACC chr13:51797079-51797099 5 5.74e-05 AGAT CGGGAGAG GAAGAAAA chr7:103630908-103630928 2 8.62e-05 C AGGCAGAG ATGGGTGTTG chr20:30457750-30457770 4 8.62e-05 GAC AGGCAGAG GCGGGACAG chr7:49815983-49816003 4 1.44e-04 TGA AGGGAAGG ATCCCAACA chr1:47696146-47696166 1 2.59e-04 . GGGGAGGG GAGGAAAGAA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGAGAG MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr11:10953300-10953320 1.4e-05 12_[+1] chr5:52774424-52774444 1.4e-05 1_[+1]_11 chr1:20812589-20812609 2.9e-05 2_[+1]_10 chr2:45167469-45167489 2.9e-05 1_[+1]_11 chr21:34443438-34443458 4.3e-05 8_[+1]_4 chr17:37756031-37756051 4.3e-05 5_[+1]_7 chr1:18958793-18958813 5.7e-05 8_[+1]_4 chr13:51797079-51797099 5.7e-05 4_[+1]_8 chr7:103630908-103630928 8.6e-05 1_[+1]_11 chr20:30457750-30457770 8.6e-05 3_[+1]_9 chr7:49815983-49816003 0.00014 3_[+1]_9 chr1:47696146-47696166 0.00026 [+1]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGAGAG MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AGGGAGAG width=8 seqs=12 chr11:10953300-10953320 ( 13) AGGGAGAG 1 chr5:52774424-52774444 ( 2) AGGGAGAG 1 chr1:20812589-20812609 ( 3) AGGGAAAG 1 chr2:45167469-45167489 ( 2) AGGGAAAG 1 chr21:34443438-34443458 ( 9) TGGGAGAG 1 chr17:37756031-37756051 ( 6) TGGGAGAG 1 chr1:18958793-18958813 ( 9) CGGGAGAG 1 chr13:51797079-51797099 ( 5) CGGGAGAG 1 chr7:103630908-103630928 ( 2) AGGCAGAG 1 chr20:30457750-30457770 ( 4) AGGCAGAG 1 chr7:49815983-49816003 ( 4) AGGGAAGG 1 chr1:47696146-47696166 ( 1) GGGGAGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGAGAG MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.73346 E= 1.3e+001 122 -62 -156 -57 -1023 -1023 202 -1023 -1023 -1023 202 -1023 -1023 -62 176 -1023 200 -1023 -1023 -1023 0 -1023 161 -1023 173 -1023 -56 -1023 -1023 -1023 202 -1023 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGAGAG MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 12 E= 1.3e+001 0.583333 0.166667 0.083333 0.166667 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.166667 0.833333 0.000000 1.000000 0.000000 0.000000 0.000000 0.250000 0.000000 0.750000 0.000000 0.833333 0.000000 0.166667 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AGGGAGAG MEME-1 regular expression -------------------------------------------------------------------------------- AGGGA[GA]AG -------------------------------------------------------------------------------- Time 4.84 secs. ******************************************************************************** ******************************************************************************** MOTIF GGGATGGG MEME-2 width = 8 sites = 2 llr = 22 E-value = 2.7e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif GGGATGGG MEME-2 Description -------------------------------------------------------------------------------- Simplified A :::a:::: pos.-specific C :::::::: probability G aaa::aaa matrix T ::::a::: bits 2.0 ******** 1.8 ******** 1.6 ******** 1.4 ******** Relative 1.2 ******** Entropy 1.0 ******** (16.1 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GGGATGGG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGGATGGG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:197885934-197885954 5 1.38e-05 AGAT GGGATGGG GAGGAGAG chr5:153855671-153855691 6 1.38e-05 GACCC GGGATGGG CTGGGCA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGGATGGG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:197885934-197885954 1.4e-05 4_[+2]_8 chr5:153855671-153855691 1.4e-05 5_[+2]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGGATGGG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GGGATGGG width=8 seqs=2 chr1:197885934-197885954 ( 5) GGGATGGG 1 chr5:153855671-153855691 ( 6) GGGATGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGGATGGG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.6653 E= 2.7e+003 -765 -765 202 -765 -765 -765 202 -765 -765 -765 202 -765 199 -765 -765 -765 -765 -765 -765 201 -765 -765 202 -765 -765 -765 202 -765 -765 -765 202 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGGATGGG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 2.7e+003 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGGATGGG MEME-2 regular expression -------------------------------------------------------------------------------- GGGATGGG -------------------------------------------------------------------------------- Time 7.49 secs. ******************************************************************************** ******************************************************************************** MOTIF GGCTTTTT MEME-3 width = 8 sites = 3 llr = 33 E-value = 2.8e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif GGCTTTTT MEME-3 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C ::a::::: probability G aa:::::: matrix T :::aaaaa bits 2.0 ******** 1.8 ******** 1.6 ******** 1.4 ******** Relative 1.2 ******** Entropy 1.0 ******** (16.1 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GGCTTTTT consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCTTTTT MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr17:56834421-56834441 6 1.45e-05 TGAAG GGCTTTTT AGATGTT chr6:127440348-127440368 12 1.45e-05 CTGATTTCTT GGCTTTTT A chr2:91670156-91670176 7 1.45e-05 CGCAGC GGCTTTTT GCACCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCTTTTT MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr17:56834421-56834441 1.5e-05 5_[+3]_7 chr6:127440348-127440368 1.5e-05 11_[+3]_1 chr2:91670156-91670176 1.5e-05 6_[+3]_6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCTTTTT MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GGCTTTTT width=8 seqs=3 chr17:56834421-56834441 ( 6) GGCTTTTT 1 chr6:127440348-127440368 ( 12) GGCTTTTT 1 chr2:91670156-91670176 ( 7) GGCTTTTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCTTTTT MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.73854 E= 2.8e+003 -823 -823 202 -823 -823 -823 202 -823 -823 196 -823 -823 -823 -823 -823 201 -823 -823 -823 201 -823 -823 -823 201 -823 -823 -823 201 -823 -823 -823 201 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCTTTTT MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 3 E= 2.8e+003 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCTTTTT MEME-3 regular expression -------------------------------------------------------------------------------- GGCTTTTT -------------------------------------------------------------------------------- Time 9.02 secs. ******************************************************************************** ******************************************************************************** MOTIF GGCGGMGA MEME-4 width = 8 sites = 9 llr = 77 E-value = 6.8e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif GGCGGMGA MEME-4 Description -------------------------------------------------------------------------------- Simplified A 1::::728 pos.-specific C ::8::3:: probability G 9a:aa:82 matrix T ::2::::: bits 2.0 * ** 1.8 * ** 1.6 * ** 1.4 ** ** Relative 1.2 ***** ** Entropy 1.0 ******** (12.4 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel GGCGGAGA consensus T CAG sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGMGA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr8:70946710-70946730 10 1.45e-05 AATCTGGAT GGCGGAGA CTG chr8:37554901-37554921 5 2.93e-05 CGGC GGCGGCGA CTCCCGCA chr10:126069752-12606977 8 4.34e-05 CTCTCGC GGTGGAGA ACAGG chr2:193060893-193060913 10 4.34e-05 GGGGACAAG GGTGGAGA GGA chr22:19747867-19747887 7 7.25e-05 ggaaga ggcggaaa gtaaaa chr2:219846063-219846083 7 7.25e-05 GAGCCA GGCGGAAA TGCACT chr2:70995196-70995216 11 1.16e-04 GCGGCTCCGC GGCGGCGG GG chr3:18486105-18486125 12 1.16e-04 GGACGTTGGG GGCGGCGG T chr7:1277516-1277536 3 1.31e-04 GG AGCGGAGA TGGGGAATCG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGMGA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr8:70946710-70946730 1.5e-05 9_[+4]_3 chr8:37554901-37554921 2.9e-05 4_[+4]_8 chr10:126069752-12606977 4.3e-05 7_[+4]_5 chr2:193060893-193060913 4.3e-05 9_[+4]_3 chr22:19747867-19747887 7.2e-05 6_[+4]_6 chr2:219846063-219846083 7.2e-05 6_[+4]_6 chr2:70995196-70995216 0.00012 10_[+4]_2 chr3:18486105-18486125 0.00012 11_[+4]_1 chr7:1277516-1277536 0.00013 2_[+4]_10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGMGA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GGCGGMGA width=8 seqs=9 chr8:70946710-70946730 ( 10) GGCGGAGA 1 chr8:37554901-37554921 ( 5) GGCGGCGA 1 chr10:126069752-12606977 ( 8) GGTGGAGA 1 chr2:193060893-193060913 ( 10) GGTGGAGA 1 chr22:19747867-19747887 ( 7) GGCGGAAA 1 chr2:219846063-219846083 ( 7) GGCGGAAA 1 chr2:70995196-70995216 ( 11) GGCGGCGG 1 chr3:18486105-18486125 ( 12) GGCGGCGG 1 chr7:1277516-1277536 ( 3) AGCGGAGA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGMGA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.89918 E= 6.8e+003 -117 -982 185 -982 -982 -982 202 -982 -982 160 -982 -16 -982 -982 202 -982 -982 -982 202 -982 141 38 -982 -982 -17 -982 166 -982 163 -982 -15 -982 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGMGA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 9 E= 6.8e+003 0.111111 0.000000 0.888889 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.777778 0.000000 0.222222 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.666667 0.333333 0.000000 0.000000 0.222222 0.000000 0.777778 0.000000 0.777778 0.000000 0.222222 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGCGGMGA MEME-4 regular expression -------------------------------------------------------------------------------- GG[CT]GG[AC][GA][AG] -------------------------------------------------------------------------------- Time 9.77 secs. ******************************************************************************** ******************************************************************************** MOTIF TWTTTWCT MEME-5 width = 8 sites = 7 llr = 66 E-value = 2.0e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif TWTTTWCT MEME-5 Description -------------------------------------------------------------------------------- Simplified A :6:::6:: pos.-specific C ::::::a: probability G :::::1:: matrix T a4aaa3:a bits 2.0 * *** ** 1.8 * *** ** 1.6 * *** ** 1.4 * *** ** Relative 1.2 * *** ** Entropy 1.0 ***** ** (13.7 bits) 0.8 ***** ** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TATTTACT consensus T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TWTTTWCT MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr5:76940041-76940061 5 1.51e-05 TTTC TATTTACT CAGGATAA chr6:138427943-138427963 5 1.51e-05 ATTA TATTTACT CATCTAAA chr14:33409618-33409638 13 1.51e-05 TTTGGAATCC TATTTACT chr22:44728101-44728121 4 3.01e-05 CTC TTTTTACT TCCTTTCCG chr4:118955214-118955234 9 5.98e-05 TAACCAGC TTTTTTCT CCTG chr6:13925786-13925806 2 5.98e-05 T TTTTTTCT TTGGAAGGTG chr11:124712340-12471236 7 7.46e-05 Tctctg tatttgct gtttac -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TWTTTWCT MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr5:76940041-76940061 1.5e-05 4_[+5]_8 chr6:138427943-138427963 1.5e-05 4_[+5]_8 chr14:33409618-33409638 1.5e-05 12_[+5] chr22:44728101-44728121 3e-05 3_[+5]_9 chr4:118955214-118955234 6e-05 8_[+5]_4 chr6:13925786-13925806 6e-05 1_[+5]_11 chr11:124712340-12471236 7.5e-05 6_[+5]_6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TWTTTWCT MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TWTTTWCT width=8 seqs=7 chr5:76940041-76940061 ( 5) TATTTACT 1 chr6:138427943-138427963 ( 5) TATTTACT 1 chr14:33409618-33409638 ( 13) TATTTACT 1 chr22:44728101-44728121 ( 4) TTTTTACT 1 chr4:118955214-118955234 ( 9) TTTTTTCT 1 chr6:13925786-13925806 ( 2) TTTTTTCT 1 chr11:124712340-12471236 ( 7) TATTTGCT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TWTTTWCT MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.46255 E= 2.0e+003 -945 -945 -945 201 119 -945 -945 79 -945 -945 -945 201 -945 -945 -945 201 -945 -945 -945 201 119 -945 -78 21 -945 197 -945 -945 -945 -945 -945 201 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TWTTTWCT MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 7 E= 2.0e+003 0.000000 0.000000 0.000000 1.000000 0.571429 0.000000 0.000000 0.428571 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.571429 0.000000 0.142857 0.285714 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TWTTTWCT MEME-5 regular expression -------------------------------------------------------------------------------- T[AT]TTT[AT]CT -------------------------------------------------------------------------------- Time 10.51 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:91670156-91670176 1.85e-03 6_[+3(1.45e-05)]_6 chr8:123685724-123685744 7.67e-01 20 chr5:141256860-141256880 5.99e-01 20 chr7:49814487-49814507 9.99e-01 20 chr7:5465233-5465253 8.58e-01 20 chr6:91004574-91004594 8.27e-01 20 chr1:145040789-145040809 7.66e-01 20 chr12:54403282-54403302 9.38e-01 20 chr9:98784671-98784691 7.22e-01 20 chr5:52774424-52774444 6.83e-03 1_[+1(1.42e-05)]_11 chr7:129423426-129423446 4.23e-01 20 chr17:77773576-77773596 7.73e-01 20 chr1:155054081-155054101 9.94e-01 20 chr11:128555978-12855599 9.33e-02 20 chr12:2162517-2162537 7.38e-03 20 chr2:54951567-54951587 1.21e-01 20 chr9:133541002-133541022 9.50e-01 20 chr1:47696677-47696697 9.88e-01 20 chr2:19561984-19562004 9.35e-01 20 chr11:31822098-31822118 9.59e-01 20 chr6:75916150-75916170 3.65e-01 20 chr3:169378788-169378808 9.51e-01 20 chr5:115297772-115297792 9.99e-01 20 chr17:77816794-77816814 9.49e-01 20 chr2:121453377-121453397 1.00e+00 20 chr12:47473131-47473151 7.08e-01 20 chr4:42398516-42398536 9.35e-01 20 chr5:92948057-92948077 9.54e-01 20 chr6:13925786-13925806 5.02e-03 1_[+5(5.98e-05)]_11 chr10:102414263-10241428 9.08e-02 20 chr10:126138990-12613901 5.98e-01 20 chr17:37756031-37756051 1.06e-02 5_[+1(4.29e-05)]_7 chr15:66545360-66545380 1.00e+00 20 chr18:56939501-56939521 8.91e-01 20 chr6:10419164-10419184 5.19e-01 20 chr5:92943662-92943682 4.75e-01 20 chr7:2560348-2560368 5.25e-01 20 chr4:121844461-121844481 1.23e-01 20 chr7:120629054-120629074 3.15e-01 20 chr1:6301539-6301559 6.18e-01 20 chr15:40211380-40211400 1.00e+00 20 chr2:175208224-175208244 8.22e-02 20 chr4:118955214-118955234 5.27e-03 8_[+5(5.98e-05)]_4 chr3:128209108-128209128 7.24e-02 20 chr1:50887498-50887518 3.30e-01 20 chr3:181442009-181442029 5.60e-01 20 chr19:18722125-18722145 6.80e-01 20 chr9:14313649-14313669 1.00e+00 20 chr4:75859686-75859706 7.21e-01 20 chr12:96185298-96185318 3.43e-02 20 chr9:126772283-126772303 5.70e-01 20 chr1:44872079-44872099 9.93e-01 20 chr4:140478659-140478679 8.62e-01 20 chr13:51797079-51797099 4.27e-03 4_[+1(5.74e-05)]_8 chr11:71951565-71951585 9.67e-01 20 chr9:100610576-100610596 1.24e-03 20 chr7:29604252-29604272 9.51e-01 20 chr13:79178266-79178286 9.99e-01 20 chr5:52775324-52775344 4.16e-01 20 chr6:106442618-106442638 9.46e-01 20 chr20:2781737-2781757 8.54e-01 20 chr17:47073883-47073903 1.00e+00 20 chr12:62586539-62586559 8.51e-01 20 chr1:156893171-156893191 8.66e-01 20 chr17:37762349-37762369 8.85e-02 20 chr10:102500540-10250056 1.41e-01 20 chr12:48397716-48397736 5.58e-01 20 chr1:47696146-47696166 7.07e-04 20 chr6:5994506-5994526 4.98e-01 20 chr12:54404234-54404254 5.44e-01 20 chr1:218339114-218339134 3.24e-01 20 chr22:46374052-46374072 8.90e-01 20 chr10:71562010-71562030 3.79e-01 20 chr1:201507973-201507993 9.86e-02 20 chr21:34444256-34444276 9.98e-01 20 chr12:54321187-54321207 7.99e-01 20 chr5:87968253-87968273 7.60e-01 20 chr2:219846063-219846083 3.42e-02 6_[+4(7.25e-05)]_6 chr5:153855671-153855691 2.87e-03 5_[+2(1.38e-05)]_7 chr11:31834273-31834293 3.63e-02 20 chr8:76319156-76319176 9.26e-01 20 chr7:25891725-25891745 7.72e-01 20 chr9:135037859-135037879 2.11e-01 20 chr14:65170617-65170637 8.83e-01 20 chr18:55468848-55468868 2.13e-01 20 chr12:54089670-54089690 2.66e-01 20 chr10:22626161-22626181 4.42e-01 20 chr18:19749941-19749961 7.75e-01 20 chr14:69726125-69726145 5.56e-01 20 chr17:30592318-30592338 8.01e-01 20 chr22:19747867-19747887 1.36e-02 6_[+4(7.25e-05)]_6 chr17:77788245-77788265 1.00e+00 20 chr5:180480718-180480738 6.92e-01 20 chr1:156595615-156595635 1.00e+00 20 chr2:111875122-111875142 9.51e-01 20 chr2:157177856-157177876 4.33e-01 20 chr1:93914652-93914672 2.85e-01 20 chr4:78979860-78979880 9.89e-01 20 chr10:102986342-10298636 6.05e-01 20 chr1:107683606-107683626 9.77e-01 20 chr3:187456029-187456049 9.81e-01 20 chr1:119522151-119522171 7.30e-01 20 chr11:130299179-13029919 6.60e-01 20 chr1:68297777-68297797 4.80e-01 20 chr11:75379519-75379539 4.41e-01 20 chr22:44728101-44728121 1.72e-02 3_[+5(3.01e-05)]_9 chr7:5462562-5462582 9.63e-01 20 chr8:37554901-37554921 4.11e-02 4_[+4(2.93e-05)]_8 chr6:45982677-45982697 9.94e-01 20 chr4:186455870-186455890 9.20e-01 20 chr8:57069557-57069577 8.89e-01 20 chr10:102586998-10258701 9.91e-01 20 chr6:126072676-126072696 1.01e-01 20 chr13:100637015-10063703 3.60e-03 20 chr11:125036748-12503676 9.37e-01 20 chr11:12697759-12697779 6.66e-01 20 chr8:21646249-21646269 9.91e-01 20 chr5:92921117-92921137 1.00e+00 20 chr11:10953300-10953320 6.27e-03 12_[+1(1.42e-05)] chr12:103355634-10335565 4.16e-01 20 chr13:107185928-10718594 8.85e-01 20 chr1:29563455-29563475 1.71e-01 20 chr6:143999687-143999707 7.43e-02 20 chr5:92947476-92947496 8.25e-01 20 chr6:126069829-126069849 1.14e-01 20 chr9:107690146-107690166 9.79e-01 20 chr11:10952291-10952311 1.00e+00 20 chr1:227505388-227505408 9.78e-01 20 chr10:102588409-10258842 4.65e-01 20 chr2:45167469-45167489 2.34e-02 1_[+1(2.88e-05)]_11 chr7:126892060-126892080 9.12e-01 20 chr6:41341518-41341538 6.05e-01 20 chr2:171569393-171569413 9.83e-01 20 chr17:36729508-36729528 8.95e-01 20 chr2:207309186-207309206 3.83e-03 20 chr6:10396042-10396062 3.41e-01 20 chr2:111875960-111875980 1.30e-01 20 chr3:35681975-35681995 2.25e-01 20 chr3:138662768-138662788 8.22e-01 20 chr3:122747372-122747392 1.07e-01 20 chr1:145039547-145039567 8.91e-01 20 chr17:46827654-46827674 1.00e+00 20 chr17:54673727-54673747 8.04e-01 20 chr2:175869313-175869333 9.80e-01 20 chr1:18956773-18956793 9.90e-01 20 chr17:47574350-47574370 4.81e-01 20 chr3:18486105-18486125 2.63e-02 20 chr7:28220680-28220700 4.23e-01 20 chr2:193060893-193060913 6.11e-03 9_[+4(4.34e-05)]_3 chr15:68870417-68870437 6.37e-01 20 chr8:70946710-70946730 1.14e-03 9_[+4(1.45e-05)]_3 chr11:10316732-10316752 8.13e-01 20 chr1:197881711-197881731 7.41e-01 20 chr9:124981492-124981512 8.52e-01 20 chr8:20160632-20160652 7.03e-01 20 chr2:63275277-63275297 2.83e-01 20 chr15:53097193-53097213 9.36e-01 20 chr3:71630429-71630449 1.78e-01 20 chr6:127440348-127440368 1.27e-02 11_[+3(1.45e-05)]_1 chr6:144608277-144608297 4.28e-01 20 chr22:17851006-17851026 1.65e-01 20 chr1:63793235-63793255 9.11e-01 20 chr1:245318575-245318595 9.60e-01 20 chr1:20812589-20812609 3.92e-03 2_[+1(2.88e-05)]_10 chr1:46957412-46957432 3.79e-01 20 chrX:71525879-71525899 8.95e-01 20 chr10:62702951-62702971 2.45e-01 20 chr2:74726100-74726120 8.43e-01 20 chr11:16626373-16626393 1.00e+00 20 chr11:64065227-64065247 1.00e+00 20 chr9:126782651-126782671 9.61e-01 20 chr7:43151784-43151804 7.25e-01 20 chr1:197885934-197885954 1.53e-04 4_[+2(1.38e-05)]_8 chr6:137813610-137813630 9.35e-01 20 chr14:103389634-10338965 6.09e-01 20 chr2:119594309-119594329 8.53e-01 20 chr2:85980411-85980431 3.91e-01 20 chr2:66802370-66802390 2.55e-01 20 chr7:150863845-150863865 1.68e-01 20 chr1:210407928-210407948 1.35e-01 20 chr2:111876939-111876959 7.46e-02 20 chr7:1277516-1277536 3.12e-03 20 chr17:56834421-56834441 1.28e-02 5_[+3(1.45e-05)]_7 chr12:52400186-52400206 9.66e-01 20 chr1:10855455-10855475 9.83e-01 20 chr12:54423819-54423839 2.00e-01 20 chr12:26112391-26112411 3.60e-02 20 chr17:36102523-36102543 9.69e-01 20 chr12:54427514-54427534 7.52e-01 20 chr1:29564703-29564723 8.94e-01 20 chr6:91005485-91005505 5.16e-01 20 chr21:34443438-34443458 3.50e-02 8_[+1(4.29e-05)]_4 chr2:102091542-102091562 7.58e-01 20 chr2:119591922-119591942 1.00e+00 20 chr12:116713854-11671387 1.47e-01 20 chr2:73147386-73147406 6.64e-01 20 chr10:73157176-73157196 8.80e-01 20 chr1:23544441-23544461 8.77e-01 20 chr2:190446153-190446173 5.26e-01 20 chr14:33409618-33409638 2.14e-02 12_[+5(1.51e-05)] chr1:64239246-64239266 7.08e-01 20 chr11:46939562-46939582 3.44e-01 20 chr10:101294305-10129432 1.00e+00 20 chr1:61548229-61548249 5.02e-01 20 chr6:138427943-138427963 5.35e-02 4_[+5(1.51e-05)]_8 chr17:36730286-36730306 5.69e-02 20 chr2:74727477-74727497 5.47e-01 20 chr11:124712340-12471236 2.51e-02 6_[+5(7.46e-05)]_6 chr6:10414854-10414874 9.27e-01 20 chr7:155258708-155258728 2.08e-01 20 chr4:55093298-55093318 4.10e-01 20 chr10:126069752-12606977 2.03e-02 7_[+4(4.34e-05)]_5 chr17:59530160-59530180 9.87e-01 20 chr20:30457750-30457770 8.52e-03 3_[+1(8.62e-05)]_9 chr18:10455379-10455399 9.50e-01 20 chr1:18958793-18958813 1.54e-02 8_[+1(5.74e-05)]_4 chr4:175443993-175444013 1.00e+00 20 chr2:70995196-70995216 2.16e-02 20 chr7:103630908-103630928 4.28e-05 1_[+1(8.62e-05)]_11 chr6:43212651-43212671 9.69e-01 20 chr7:155167568-155167588 8.71e-01 20 chr2:175203902-175203922 5.00e-01 20 chr17:35290350-35290370 8.84e-01 20 chr3:55517426-55517446 9.97e-01 20 chr7:1279585-1279605 9.50e-01 20 chr2:60788254-60788274 1.00e+00 20 chr5:128796684-128796704 8.83e-01 20 chr18:53255755-53255775 1.00e+00 20 chr8:77593888-77593908 6.40e-01 20 chr15:68116622-68116642 9.04e-01 20 chr2:17719736-17719756 1.00e+00 20 chr15:73343534-73343554 9.05e-01 20 chr2:162283321-162283341 4.82e-01 20 chr17:6459099-6459119 9.96e-01 20 chr12:54388832-54388852 2.26e-01 20 chr15:65668557-65668577 1.00e+00 20 chr12:54360822-54360842 9.81e-01 20 chr13:114462628-11446264 4.82e-01 20 chr2:219849506-219849526 9.98e-01 20 chr17:79368703-79368723 4.32e-01 20 chr7:49815983-49816003 2.30e-02 20 chr3:157821698-157821718 8.41e-01 20 chr2:175195108-175195128 9.92e-01 20 chr4:55093780-55093800 9.46e-01 20 chr5:76940041-76940061 2.47e-02 4_[+5(1.51e-05)]_8 chr8:144511086-144511106 5.05e-01 20 chr2:46523867-46523887 8.06e-01 20 chr6:21666835-21666855 3.76e-01 20 chr16:2077635-2077655 9.97e-01 20 chr6:100913605-100913625 9.99e-01 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n10.farnam.hpc.yale.internal ********************************************************************************