******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/ELF1.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr2:241500609-241500629 1.0000 20 chr1:231473708-231473728 1.0000 20 chr20:33735165-33735185 1.0000 20 chr17:80408669-80408689 1.0000 20 chr9:68726423-68726443 1.0000 20 chr9:97021568-97021588 1.0000 20 chr5:93447388-93447408 1.0000 20 chr9:69065466-69065486 1.0000 20 chr19:53073548-53073568 1.0000 20 chr16:67193801-67193821 1.0000 20 chr19:53837001-53837021 1.0000 20 chr19:53360841-53360861 1.0000 20 chr7:98923492-98923512 1.0000 20 chr16:88877905-88877925 1.0000 20 chr11:114271313-11427133 1.0000 20 chr19:53898403-53898423 1.0000 20 chr21:34100327-34100347 1.0000 20 chr12:54582894-54582914 1.0000 20 chr6:8435772-8435792 1.0000 20 chr8:21776026-21776046 1.0000 20 chr17:7358856-7358876 1.0000 20 chr10:16859704-16859724 1.0000 20 chr16:69796194-69796214 1.0000 20 chr8:144623767-144623787 1.0000 20 chr10:124134070-12413409 1.0000 20 chr3:195681431-195681451 1.0000 20 chr8:10874064-10874084 1.0000 20 chr10:74870195-74870215 1.0000 20 chr1:22755273-22755293 1.0000 20 chr1:231376914-231376934 1.0000 20 chrX:15873151-15873171 1.0000 20 chr20:37678854-37678874 1.0000 20 chr16:77225035-77225055 1.0000 20 chr19:53238289-53238309 1.0000 20 chr7:111846557-111846577 1.0000 20 chr19:1174251-1174271 1.0000 20 chr5:85913685-85913705 1.0000 20 chrX:155110941-155110961 1.0000 20 chr19:2042305-2042325 1.0000 20 chr20:2082860-2082880 1.0000 20 chr15:55611345-55611365 1.0000 20 chr3:119419546-119419566 1.0000 20 chr2:113342000-113342020 1.0000 20 chr16:30546338-30546358 1.0000 20 chr12:64616060-64616080 1.0000 20 chr6:43149860-43149880 1.0000 20 chr17:4046318-4046338 1.0000 20 chr17:34957996-34958016 1.0000 20 chr15:91565844-91565864 1.0000 20 chr21:17104793-17104813 1.0000 20 chr1:16302582-16302602 1.0000 20 chr9:99329249-99329269 1.0000 20 chr10:46222629-46222649 1.0000 20 chr16:15150047-15150067 1.0000 20 chr19:7459982-7460002 1.0000 20 chrX:47518538-47518558 1.0000 20 chrX:48432717-48432737 1.0000 20 chr17:37886755-37886775 1.0000 20 chr4:10118473-10118493 1.0000 20 chr3:3168605-3168625 1.0000 20 chr9:102861350-102861370 1.0000 20 chr10:126150286-12615030 1.0000 20 chr18:55297510-55297530 1.0000 20 chr11:124492753-12449277 1.0000 20 chr17:38375473-38375493 1.0000 20 chr9:127962738-127962758 1.0000 20 chr19:41082745-41082765 1.0000 20 chr20:48429405-48429425 1.0000 20 chr9:128024008-128024028 1.0000 20 chr7:97601661-97601681 1.0000 20 chr12:57984983-57985003 1.0000 20 chr1:155211070-155211090 1.0000 20 chr9:130548291-130548311 1.0000 20 chr8:22526631-22526651 1.0000 20 chr6:45345829-45345849 1.0000 20 chr19:53606666-53606686 1.0000 20 chr3:130745659-130745679 1.0000 20 chr17:48075806-48075826 1.0000 20 chr12:112123797-11212381 1.0000 20 chr2:48667911-48667931 1.0000 20 chr11:69490124-69490144 1.0000 20 chr19:6863677-6863697 1.0000 20 chr6:89673350-89673370 1.0000 20 chr16:2723568-2723588 1.0000 20 chr14:59951149-59951169 1.0000 20 chr2:55459518-55459538 1.0000 20 chr1:24117581-24117601 1.0000 20 chr19:36208596-36208616 1.0000 20 chr6:3069182-3069202 1.0000 20 chr13:79233272-79233292 1.0000 20 chr17:80163939-80163959 1.0000 20 chr17:18684534-18684554 1.0000 20 chr16:28936502-28936522 1.0000 20 chr18:21083390-21083410 1.0000 20 chr9:32552290-32552310 1.0000 20 chr19:18133071-18133091 1.0000 20 chr11:70049332-70049352 1.0000 20 chr2:210867263-210867283 1.0000 20 chr1:1655842-1655862 1.0000 20 chr19:58361175-58361195 1.0000 20 chr19:53445794-53445814 1.0000 20 chr6:88412118-88412138 1.0000 20 chr15:74392576-74392596 1.0000 20 chr5:6378654-6378674 1.0000 20 chr20:43595072-43595092 1.0000 20 chr2:101179357-101179377 1.0000 20 chr6:158981087-158981107 1.0000 20 chr12:1800091-1800111 1.0000 20 chr19:14800840-14800860 1.0000 20 chr6:24721505-24721525 1.0000 20 chr12:108908941-10890896 1.0000 20 chr19:44576217-44576237 1.0000 20 chr8:21966971-21966991 1.0000 20 chr6:109804412-109804432 1.0000 20 chr8:681229-681249 1.0000 20 chr11:47736934-47736954 1.0000 20 chr20:2821317-2821337 1.0000 20 chr17:62833327-62833347 1.0000 20 chr7:72722841-72722861 1.0000 20 chr2:198318109-198318129 1.0000 20 chr1:24127396-24127416 1.0000 20 chr6:37786761-37786781 1.0000 20 chr1:235324574-235324594 1.0000 20 chr9:139258251-139258271 1.0000 20 chr17:79269084-79269104 1.0000 20 chr11:64052991-64053011 1.0000 20 chr7:99613168-99613188 1.0000 20 chr3:194304707-194304727 1.0000 20 chr4:166128717-166128737 1.0000 20 chr1:107599248-107599268 1.0000 20 chr4:6576920-6576940 1.0000 20 chr8:18067592-18067612 1.0000 20 chr20:18774669-18774689 1.0000 20 chr2:3381628-3381648 1.0000 20 chr19:57998989-57999009 1.0000 20 chr10:27531085-27531105 1.0000 20 chr22:24093355-24093375 1.0000 20 chr1:200589928-200589948 1.0000 20 chr1:172413213-172413233 1.0000 20 chr11:94801897-94801917 1.0000 20 chr3:48701610-48701630 1.0000 20 chr19:44556026-44556046 1.0000 20 chr22:41986095-41986115 1.0000 20 chr17:73452611-73452631 1.0000 20 chr15:57998879-57998899 1.0000 20 chr19:38826391-38826411 1.0000 20 chr17:35306197-35306217 1.0000 20 chr19:44669168-44669188 1.0000 20 chr20:1373829-1373849 1.0000 20 chr16:29937517-29937537 1.0000 20 chr6:71377477-71377497 1.0000 20 chr11:66112582-66112602 1.0000 20 chr19:58892685-58892705 1.0000 20 chr11:36531800-36531820 1.0000 20 chr6:8064754-8064774 1.0000 20 chr2:242626403-242626423 1.0000 20 chr16:14724102-14724122 1.0000 20 chr19:54024127-54024147 1.0000 20 chr12:64798086-64798106 1.0000 20 chr5:162932551-162932571 1.0000 20 chr11:119155480-11915550 1.0000 20 chr19:58427997-58428017 1.0000 20 chr16:3508000-3508020 1.0000 20 chr12:125473662-12547368 1.0000 20 chr7:157129642-157129662 1.0000 20 chr9:34458570-34458590 1.0000 20 chr11:59436588-59436608 1.0000 20 chr5:60458282-60458302 1.0000 20 chr1:23694886-23694906 1.0000 20 chr1:36851671-36851691 1.0000 20 chr7:130692414-130692434 1.0000 20 chr18:55289117-55289137 1.0000 20 chr1:118472312-118472332 1.0000 20 chr2:128458972-128458992 1.0000 20 chr10:119806398-11980641 1.0000 20 chr1:33116155-33116175 1.0000 20 chr5:140079871-140079891 1.0000 20 chr7:39989825-39989845 1.0000 20 chr2:243030820-243030840 1.0000 20 chr11:9336384-9336404 1.0000 20 chr1:110036729-110036749 1.0000 20 chr17:33446870-33446890 1.0000 20 chr1:40942857-40942877 1.0000 20 chr17:47022197-47022217 1.0000 20 chr19:41284130-41284150 1.0000 20 chr8:87520952-87520972 1.0000 20 chr1:22379119-22379139 1.0000 20 chr11:65655963-65655983 1.0000 20 chr2:196933619-196933639 1.0000 20 chrX:40506903-40506923 1.0000 20 chr7:6121127-6121147 1.0000 20 chr6:43543826-43543846 1.0000 20 chr7:100895587-100895607 1.0000 20 chr19:18668671-18668691 1.0000 20 chr22:38577851-38577871 1.0000 20 chrX:69353715-69353735 1.0000 20 chr16:89557292-89557312 1.0000 20 chr19:56632881-56632901 1.0000 20 chr7:23636932-23636952 1.0000 20 chr19:38397727-38397747 1.0000 20 chr11:45939436-45939456 1.0000 20 chr4:2470770-2470790 1.0000 20 chr9:33264950-33264970 1.0000 20 chr9:130700154-130700174 1.0000 20 chr11:64107636-64107656 1.0000 20 chr5:16465890-16465910 1.0000 20 chr19:19496559-19496579 1.0000 20 chr6:147523630-147523650 1.0000 20 chr17:8093597-8093617 1.0000 20 chr17:406362-406382 1.0000 20 chr1:52499478-52499498 1.0000 20 chr1:40283143-40283163 1.0000 20 chr8:67525799-67525819 1.0000 20 chr17:17936939-17936959 1.0000 20 chr3:75834719-75834739 1.0000 20 chr17:16439130-16439150 1.0000 20 chr7:99102801-99102821 1.0000 20 chr2:136499176-136499196 1.0000 20 chr16:4524675-4524695 1.0000 20 chr4:83812409-83812429 1.0000 20 chr12:94071100-94071120 1.0000 20 chr19:55629177-55629197 1.0000 20 chr17:40688154-40688174 1.0000 20 chr17:40346523-40346543 1.0000 20 chr11:61197555-61197575 1.0000 20 chr15:78832715-78832735 1.0000 20 chr15:36871714-36871734 1.0000 20 chr2:69870946-69870966 1.0000 20 chr12:112856653-11285667 1.0000 20 chr19:52772826-52772846 1.0000 20 chr22:30234257-30234277 1.0000 20 chr7:1199892-1199912 1.0000 20 chr9:101018114-101018134 1.0000 20 chr6:108395925-108395945 1.0000 20 chr18:61089791-61089811 1.0000 20 chr8:11141912-11141932 1.0000 20 chr1:59282137-59282157 1.0000 20 chr11:67030350-67030370 1.0000 20 chr7:38948795-38948815 1.0000 20 chr19:19626980-19627000 1.0000 20 chr22:32146139-32146159 1.0000 20 chr17:72772514-72772534 1.0000 20 chr19:53289991-53290011 1.0000 20 chr7:6865943-6865963 1.0000 20 chr1:16693565-16693585 1.0000 20 chr16:31470699-31470719 1.0000 20 chr8:6264082-6264102 1.0000 20 chr12:62860564-62860584 1.0000 20 chr9:35604161-35604181 1.0000 20 chr20:55043671-55043691 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_ELF1/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/ELF1.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.169 C 0.336 G 0.321 T 0.174 Background letter frequencies (from file dataset with add-one prior applied): A 0.169 C 0.336 G 0.321 T 0.174 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF RCTTCCGG MEME-1 width = 8 sites = 41 llr = 322 E-value = 2.4e-029 ******************************************************************************** -------------------------------------------------------------------------------- Motif RCTTCCGG MEME-1 Description -------------------------------------------------------------------------------- Simplified A 6:::::1: pos.-specific C :9::aa:2 probability G 4:::::77 matrix T 11aa::2: bits 2.6 ** 2.3 ** 2.1 ** 1.8 ** Relative 1.5 **** Entropy 1.3 **** (11.3 bits) 1.0 ****** 0.8 ******* 0.5 ******** 0.3 ******** 0.0 -------- Multilevel ACTTCCGG consensus G C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCTTCCGG MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr9:34458570-34458590 8 2.00e-05 CAACTCC ACTTCCGG GTCCG chr12:125473662-12547368 5 2.00e-05 TGAG ACTTCCGG GTTGTGTT chr16:14724102-14724122 4 2.00e-05 gcg acttccgg aaacagcgc chr1:172413213-172413233 5 2.00e-05 AAGC ACTTCCGG GTCCGCCG chr1:235324574-235324594 12 2.00e-05 GCCAGCTCGC ACTTCCGG G chr7:72722841-72722861 5 2.00e-05 CCGG ACTTCCGG GGTCAAAA chr12:64616060-64616080 4 2.00e-05 CGC ACTTCCGG GTTCTGAGG chr20:37678854-37678874 2 2.00e-05 G ACTTCCGG GTCGGCGTTG chr7:98923492-98923512 4 2.00e-05 TCC ACTTCCGG GATCTGTCA chr1:59282137-59282157 4 3.08e-05 GGC ACTTCCTG CTTTTGCTC chr5:16465890-16465910 3 3.08e-05 CG ACTTCCTG ATTGTCACTG chr1:1655842-1655862 9 3.08e-05 TGTGCGGC ACTTCCTG TGTC chr3:119419546-119419566 4 3.08e-05 TGG ACTTCCTG GTTCAATAG chr6:108395925-108395945 2 6.88e-05 C GCTTCCGG TTTCCGCGAG chr17:406362-406382 13 6.88e-05 GGGGTGAATG GCTTCCGG chr11:45939436-45939456 5 6.88e-05 TCCT GCTTCCGG TCTTAGGC chr17:33446870-33446890 4 6.88e-05 GCC GCTTCCGG GTTCCAGGC chr2:242626403-242626423 6 6.88e-05 CCTGG GCTTCCGG GGCGGAA chr10:27531085-27531105 3 6.88e-05 GC GCTTCCGG ACACGTCCCA chr17:80163939-80163959 13 6.88e-05 GGACCATGAA GCTTCCGG chr17:72772514-72772534 10 8.98e-05 GCCCCGCCC ACTTCCGC CAT chr8:11141912-11141932 5 8.98e-05 TGCG ACTTCCGC GTCTTCCG chr15:78832715-78832735 3 8.98e-05 GG ACTTCCGC GTCCTCGGCC chr1:22379119-22379139 1 8.98e-05 . ACTTCCGC GGGCACCCAA chr2:128458972-128458992 1 8.98e-05 . ACTTCCGC GAGCGCCGCA chr6:45345829-45345849 5 8.98e-05 AGCT ACTTCCGC CACGCTCG chr5:6378654-6378674 10 1.42e-04 TACGCTCCC GCTTCCTG CTT chr9:130700154-130700174 2 1.74e-04 C TCTTCCGG CTTTGGACTG chr9:139258251-139258271 9 1.74e-04 GGCTTCCG TCTTCCGG GTCG chr11:36531800-36531820 5 2.13e-04 CACT GCTTCCGC CTTCTCTG chr1:40942857-40942877 9 2.39e-04 CTCGGGCG GCTTCCAG CTTC chr16:4524675-4524695 10 2.70e-04 CTCGGCGTC GTTTCCGG GTT chr17:80408669-80408689 1 3.24e-04 . ACTTTcgg gggcggggcc chr11:124492753-12449277 7 3.93e-04 GGGCTT ACTTCCAA GACAGA chr19:18133071-18133091 1 4.39e-04 . gtttcctg tgtggtcatg chr10:126150286-12615030 13 4.39e-04 GCCGCGCCCC AGTTCCGG chr15:74392576-74392596 5 4.61e-04 TTCT TTTTCCGG TCCCGCCA chr1:200589928-200589948 6 4.82e-04 CCTTT GCTTCCAC CCGCCCC chr11:114271313-11427133 10 5.23e-04 GGACGTGGG GCTTCCGT GAA chr11:59436588-59436608 5 5.50e-04 TCCC GCTTCCTA GTCTCAGC chr19:58361175-58361195 5 5.92e-04 AGGC ATTTCCAC GTGTGCAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCTTCCGG MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:34458570-34458590 2e-05 7_[+1]_5 chr12:125473662-12547368 2e-05 4_[+1]_8 chr16:14724102-14724122 2e-05 3_[+1]_9 chr1:172413213-172413233 2e-05 4_[+1]_8 chr1:235324574-235324594 2e-05 11_[+1]_1 chr7:72722841-72722861 2e-05 4_[+1]_8 chr12:64616060-64616080 2e-05 3_[+1]_9 chr20:37678854-37678874 2e-05 1_[+1]_11 chr7:98923492-98923512 2e-05 3_[+1]_9 chr1:59282137-59282157 3.1e-05 3_[+1]_9 chr5:16465890-16465910 3.1e-05 2_[+1]_10 chr1:1655842-1655862 3.1e-05 8_[+1]_4 chr3:119419546-119419566 3.1e-05 3_[+1]_9 chr6:108395925-108395945 6.9e-05 1_[+1]_11 chr17:406362-406382 6.9e-05 12_[+1] chr11:45939436-45939456 6.9e-05 4_[+1]_8 chr17:33446870-33446890 6.9e-05 3_[+1]_9 chr2:242626403-242626423 6.9e-05 5_[+1]_7 chr10:27531085-27531105 6.9e-05 2_[+1]_10 chr17:80163939-80163959 6.9e-05 12_[+1] chr17:72772514-72772534 9e-05 9_[+1]_3 chr8:11141912-11141932 9e-05 4_[+1]_8 chr15:78832715-78832735 9e-05 2_[+1]_10 chr1:22379119-22379139 9e-05 [+1]_12 chr2:128458972-128458992 9e-05 [+1]_12 chr6:45345829-45345849 9e-05 4_[+1]_8 chr5:6378654-6378674 0.00014 9_[+1]_3 chr9:130700154-130700174 0.00017 1_[+1]_11 chr9:139258251-139258271 0.00017 8_[+1]_4 chr11:36531800-36531820 0.00021 4_[+1]_8 chr1:40942857-40942877 0.00024 8_[+1]_4 chr16:4524675-4524695 0.00027 9_[+1]_3 chr17:80408669-80408689 0.00032 [+1]_12 chr11:124492753-12449277 0.00039 6_[+1]_6 chr19:18133071-18133091 0.00044 [+1]_12 chr10:126150286-12615030 0.00044 12_[+1] chr15:74392576-74392596 0.00046 4_[+1]_8 chr1:200589928-200589948 0.00048 5_[+1]_7 chr11:114271313-11427133 0.00052 9_[+1]_3 chr11:59436588-59436608 0.00055 4_[+1]_8 chr19:58361175-58361195 0.00059 4_[+1]_8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCTTCCGG MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF RCTTCCGG width=8 seqs=41 chr9:34458570-34458590 ( 8) ACTTCCGG 1 chr12:125473662-12547368 ( 5) ACTTCCGG 1 chr16:14724102-14724122 ( 4) ACTTCCGG 1 chr1:172413213-172413233 ( 5) ACTTCCGG 1 chr1:235324574-235324594 ( 12) ACTTCCGG 1 chr7:72722841-72722861 ( 5) ACTTCCGG 1 chr12:64616060-64616080 ( 4) ACTTCCGG 1 chr20:37678854-37678874 ( 2) ACTTCCGG 1 chr7:98923492-98923512 ( 4) ACTTCCGG 1 chr1:59282137-59282157 ( 4) ACTTCCTG 1 chr5:16465890-16465910 ( 3) ACTTCCTG 1 chr1:1655842-1655862 ( 9) ACTTCCTG 1 chr3:119419546-119419566 ( 4) ACTTCCTG 1 chr6:108395925-108395945 ( 2) GCTTCCGG 1 chr17:406362-406382 ( 13) GCTTCCGG 1 chr11:45939436-45939456 ( 5) GCTTCCGG 1 chr17:33446870-33446890 ( 4) GCTTCCGG 1 chr2:242626403-242626423 ( 6) GCTTCCGG 1 chr10:27531085-27531105 ( 3) GCTTCCGG 1 chr17:80163939-80163959 ( 13) GCTTCCGG 1 chr17:72772514-72772534 ( 10) ACTTCCGC 1 chr8:11141912-11141932 ( 5) ACTTCCGC 1 chr15:78832715-78832735 ( 3) ACTTCCGC 1 chr1:22379119-22379139 ( 1) ACTTCCGC 1 chr2:128458972-128458992 ( 1) ACTTCCGC 1 chr6:45345829-45345849 ( 5) ACTTCCGC 1 chr5:6378654-6378674 ( 10) GCTTCCTG 1 chr9:130700154-130700174 ( 2) TCTTCCGG 1 chr9:139258251-139258271 ( 9) TCTTCCGG 1 chr11:36531800-36531820 ( 5) GCTTCCGC 1 chr1:40942857-40942877 ( 9) GCTTCCAG 1 chr16:4524675-4524695 ( 10) GTTTCCGG 1 chr17:80408669-80408689 ( 1) ACTTTCGG 1 chr11:124492753-12449277 ( 7) ACTTCCAA 1 chr19:18133071-18133091 ( 1) GTTTCCTG 1 chr10:126150286-12615030 ( 13) AGTTCCGG 1 chr15:74392576-74392596 ( 5) TTTTCCGG 1 chr1:200589928-200589948 ( 6) GCTTCCAC 1 chr11:114271313-11427133 ( 10) GCTTCCGT 1 chr11:59436588-59436608 ( 5) GCTTCCTA 1 chr19:58361175-58361195 ( 5) ATTTCCAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCTTCCGG MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.79183 E= 2.4e-029 173 -1200 19 -125 -1200 139 -371 -84 -1200 -1200 -1200 252 -1200 -1200 -1200 252 -1200 154 -1200 -284 -1200 158 -1200 -1200 -79 -1200 119 -3 -179 -61 114 -284 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCTTCCGG MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 41 E= 2.4e-029 0.560976 0.000000 0.365854 0.073171 0.000000 0.878049 0.024390 0.097561 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.975610 0.000000 0.024390 0.000000 1.000000 0.000000 0.000000 0.097561 0.000000 0.731707 0.170732 0.048780 0.219512 0.707317 0.024390 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCTTCCGG MEME-1 regular expression -------------------------------------------------------------------------------- [AG]CTTCCG[GC] -------------------------------------------------------------------------------- Time 2.07 secs. ******************************************************************************** ******************************************************************************** MOTIF CGGAAGYS MEME-2 width = 8 sites = 40 llr = 304 E-value = 3.7e-024 ******************************************************************************** -------------------------------------------------------------------------------- Motif CGGAAGYS MEME-2 Description -------------------------------------------------------------------------------- Simplified A 2::aa222 pos.-specific C 6:::::34 probability G 2aa::9:5 matrix T 1:::::6: bits 2.6 ** 2.3 ** 2.1 ** 1.8 ** Relative 1.5 **** Entropy 1.3 ***** (11.0 bits) 1.0 ***** 0.8 ****** 0.5 ****** 0.3 ******** 0.0 -------- Multilevel CGGAAGTG consensus A CC sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGGAAGYS MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr20:55043671-55043691 1 1.77e-05 . CGGAAGTG GCTGCGGATT chr11:67030350-67030370 6 1.77e-05 cactc cggaagtg gggaagg chr9:130548291-130548311 11 1.77e-05 gccgcgaggc cggaagtg gc chr2:113342000-113342020 13 1.77e-05 CAGAAGAGGG CGGAAGTG chr9:69065466-69065486 4 1.77e-05 ACC CGGAAGTG GAAATCTCA chr5:60458282-60458302 13 3.63e-05 AGCAGGAAGG CGGAAGTC chr13:79233272-79233292 9 3.63e-05 CGCCAACA CGGAAGTC CCGC chr6:3069182-3069202 11 3.63e-05 ccgccggTAC CGGAAGTC GG chr1:40283143-40283163 2 4.52e-05 C AGGAAGTG AAGCTGTCCT chr22:41986095-41986115 1 4.52e-05 . AGGAAGTG AGAGGGTGAA chr16:15150047-15150067 11 4.52e-05 GTCCAAAGCC AGGAAGTG GC chr21:17104793-17104813 13 4.52e-05 GCTGGTAACT AGGAAGTG chr4:2470770-2470790 1 5.45e-05 . CGGAAGTA GAGTAGGCGG chr7:6121127-6121147 5 5.45e-05 ACCC CGGAAGTA GCCCTTCT chr17:8093597-8093617 13 6.39e-05 CGCGGCGACC AGGAAGTC chr17:17936939-17936959 8 6.86e-05 CAAGAAG AGGAAGTA CTGGT chr10:74870195-74870215 6 9.48e-05 ATTCT GGGAAGTG TGGCAGA chr1:118472312-118472332 12 1.46e-04 GAACCTCTGG CGGAAGAG G chr7:97601661-97601681 3 1.46e-04 CC CGGAAGCG CTCGCCGCCG chr19:53898403-53898423 4 1.46e-04 ACC CGGAAGCG GACGGCGTG chr19:53837001-53837021 6 1.46e-04 AAACC CGGAAGCG GATCGCA chr19:55629177-55629197 1 1.78e-04 . GGGAAGTC CGCAGCTCCG chr7:38948795-38948815 9 2.37e-04 GACAGACC CGGAAATA AGAG chr17:40688154-40688174 10 2.37e-04 CCTGGTACC CGGAAGCC GCG chr5:162932551-162932571 7 2.37e-04 TGGCAG CGGAAGCC GGAAGC chr16:29937517-29937537 9 2.37e-04 GCACCACC CGGAAGCC GGCG chr20:1373829-1373849 10 2.37e-04 AAGAGGGAC CGGAAGCC CAG chr19:2042305-2042325 12 2.37e-04 TGTTGCTAGG CGGAAGCC C chr17:7358856-7358876 6 2.37e-04 GCTCT CGGAAGAC GCTGTGG chr11:47736934-47736954 1 2.72e-04 . AGGAAGCG GAGAAAGGGC chr8:18067592-18067612 13 3.13e-04 CTGCAGACTT TGGAAGTG chr10:124134070-12413409 12 3.43e-04 cgcTGGAACC AGGAAGAC G chr9:127962738-127962758 3 4.56e-04 CA GGGAAGAG GGAGCGGTTG chr17:40346523-40346543 9 4.65e-04 CCCCAACT GGGAAATC CGGC chr6:37786761-37786781 3 5.64e-04 CC GGGAAGCC AGAGCTCCAC chr17:48075806-48075826 9 5.64e-04 GCTCCACT GGGAAGAC CCGG chr7:6865943-6865963 4 5.83e-04 GCC CGGAAAAA GAATCCGCC chr19:58427997-58428017 4 5.83e-04 ACG TGGAAATG CCTTCTTTC chrX:48432717-48432737 2 5.83e-04 C CGGAAACA CCCCATTTCG chr9:33264950-33264970 7 7.32e-04 AGAATC GGGAAACG CCAGGA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGGAAGYS MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr20:55043671-55043691 1.8e-05 [+2]_12 chr11:67030350-67030370 1.8e-05 5_[+2]_7 chr9:130548291-130548311 1.8e-05 10_[+2]_2 chr2:113342000-113342020 1.8e-05 12_[+2] chr9:69065466-69065486 1.8e-05 3_[+2]_9 chr5:60458282-60458302 3.6e-05 12_[+2] chr13:79233272-79233292 3.6e-05 8_[+2]_4 chr6:3069182-3069202 3.6e-05 10_[+2]_2 chr1:40283143-40283163 4.5e-05 1_[+2]_11 chr22:41986095-41986115 4.5e-05 [+2]_12 chr16:15150047-15150067 4.5e-05 10_[+2]_2 chr21:17104793-17104813 4.5e-05 12_[+2] chr4:2470770-2470790 5.5e-05 [+2]_12 chr7:6121127-6121147 5.5e-05 4_[+2]_8 chr17:8093597-8093617 6.4e-05 12_[+2] chr17:17936939-17936959 6.9e-05 7_[+2]_5 chr10:74870195-74870215 9.5e-05 5_[+2]_7 chr1:118472312-118472332 0.00015 11_[+2]_1 chr7:97601661-97601681 0.00015 2_[+2]_10 chr19:53898403-53898423 0.00015 3_[+2]_9 chr19:53837001-53837021 0.00015 5_[+2]_7 chr19:55629177-55629197 0.00018 [+2]_12 chr7:38948795-38948815 0.00024 8_[+2]_4 chr17:40688154-40688174 0.00024 9_[+2]_3 chr5:162932551-162932571 0.00024 6_[+2]_6 chr16:29937517-29937537 0.00024 8_[+2]_4 chr20:1373829-1373849 0.00024 9_[+2]_3 chr19:2042305-2042325 0.00024 11_[+2]_1 chr17:7358856-7358876 0.00024 5_[+2]_7 chr11:47736934-47736954 0.00027 [+2]_12 chr8:18067592-18067612 0.00031 12_[+2] chr10:124134070-12413409 0.00034 11_[+2]_1 chr9:127962738-127962758 0.00046 2_[+2]_10 chr17:40346523-40346543 0.00047 8_[+2]_4 chr6:37786761-37786781 0.00056 2_[+2]_10 chr17:48075806-48075826 0.00056 8_[+2]_4 chr7:6865943-6865963 0.00058 3_[+2]_9 chr19:58427997-58428017 0.00058 3_[+2]_9 chrX:48432717-48432737 0.00058 1_[+2]_11 chr9:33264950-33264970 0.00073 6_[+2]_6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGGAAGYS MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CGGAAGYS width=8 seqs=40 chr20:55043671-55043691 ( 1) CGGAAGTG 1 chr11:67030350-67030370 ( 6) CGGAAGTG 1 chr9:130548291-130548311 ( 11) CGGAAGTG 1 chr2:113342000-113342020 ( 13) CGGAAGTG 1 chr9:69065466-69065486 ( 4) CGGAAGTG 1 chr5:60458282-60458302 ( 13) CGGAAGTC 1 chr13:79233272-79233292 ( 9) CGGAAGTC 1 chr6:3069182-3069202 ( 11) CGGAAGTC 1 chr1:40283143-40283163 ( 2) AGGAAGTG 1 chr22:41986095-41986115 ( 1) AGGAAGTG 1 chr16:15150047-15150067 ( 11) AGGAAGTG 1 chr21:17104793-17104813 ( 13) AGGAAGTG 1 chr4:2470770-2470790 ( 1) CGGAAGTA 1 chr7:6121127-6121147 ( 5) CGGAAGTA 1 chr17:8093597-8093617 ( 13) AGGAAGTC 1 chr17:17936939-17936959 ( 8) AGGAAGTA 1 chr10:74870195-74870215 ( 6) GGGAAGTG 1 chr1:118472312-118472332 ( 12) CGGAAGAG 1 chr7:97601661-97601681 ( 3) CGGAAGCG 1 chr19:53898403-53898423 ( 4) CGGAAGCG 1 chr19:53837001-53837021 ( 6) CGGAAGCG 1 chr19:55629177-55629197 ( 1) GGGAAGTC 1 chr7:38948795-38948815 ( 9) CGGAAATA 1 chr17:40688154-40688174 ( 10) CGGAAGCC 1 chr5:162932551-162932571 ( 7) CGGAAGCC 1 chr16:29937517-29937537 ( 9) CGGAAGCC 1 chr20:1373829-1373849 ( 10) CGGAAGCC 1 chr19:2042305-2042325 ( 12) CGGAAGCC 1 chr17:7358856-7358876 ( 6) CGGAAGAC 1 chr11:47736934-47736954 ( 1) AGGAAGCG 1 chr8:18067592-18067612 ( 13) TGGAAGTG 1 chr10:124134070-12413409 ( 12) AGGAAGAC 1 chr9:127962738-127962758 ( 3) GGGAAGAG 1 chr17:40346523-40346543 ( 9) GGGAAATC 1 chr6:37786761-37786781 ( 3) GGGAAGCC 1 chr17:48075806-48075826 ( 9) GGGAAGAC 1 chr7:6865943-6865963 ( 4) CGGAAAAA 1 chr19:58427997-58428017 ( 4) TGGAAATG 1 chrX:48432717-48432737 ( 2) CGGAAACA 1 chr9:33264950-33264970 ( 7) GGGAAACG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGGAAGYS MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.39892 E= 3.7e-024 24 78 -87 -180 -1197 -1197 164 -1197 -1197 -1197 164 -1197 256 -1197 -1197 -1197 256 -1197 -1197 -1197 -17 -1197 141 -1197 -17 -16 -1197 166 -17 16 57 -1197 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGGAAGYS MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 40 E= 3.7e-024 0.200000 0.575000 0.175000 0.050000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.150000 0.000000 0.850000 0.000000 0.150000 0.300000 0.000000 0.550000 0.150000 0.375000 0.475000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGGAAGYS MEME-2 regular expression -------------------------------------------------------------------------------- [CA]GGAAG[TC][GC] -------------------------------------------------------------------------------- Time 2.85 secs. ******************************************************************************** ******************************************************************************** MOTIF TCWRCAAA MEME-3 width = 8 sites = 4 llr = 44 E-value = 5.8e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCWRCAAA MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::55:aaa pos.-specific C :a::a::: probability G :::5:::: matrix T a:5::::: bits 2.6 * *** 2.3 * *** 2.1 * *** 1.8 * *** Relative 1.5 *** **** Entropy 1.3 *** **** (16.0 bits) 1.0 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel TCAACAAA consensus TG sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWRCAAA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr12:94071100-94071120 11 5.50e-06 GTACTTGCCC TCAACAAA GA chr6:24721505-24721525 10 5.50e-06 CAACCATCC TCAACAAA ACA chr19:38826391-38826411 12 1.59e-05 AGGGCGTGCC TCTGCAAA G chr8:21776026-21776046 10 1.59e-05 tgccctacc tctgcaaa cca -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWRCAAA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:94071100-94071120 5.5e-06 10_[+3]_2 chr6:24721505-24721525 5.5e-06 9_[+3]_3 chr19:38826391-38826411 1.6e-05 11_[+3]_1 chr8:21776026-21776046 1.6e-05 9_[+3]_3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWRCAAA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCWRCAAA width=8 seqs=4 chr12:94071100-94071120 ( 11) TCAACAAA 1 chr6:24721505-24721525 ( 10) TCAACAAA 1 chr19:38826391-38826411 ( 12) TCTGCAAA 1 chr8:21776026-21776046 ( 10) TCTGCAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWRCAAA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.4021 E= 5.8e+002 -865 -865 -865 252 -865 157 -865 -865 156 -865 -865 152 156 -865 64 -865 -865 157 -865 -865 256 -865 -865 -865 256 -865 -865 -865 256 -865 -865 -865 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWRCAAA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 5.8e+002 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.500000 0.500000 0.000000 0.500000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCWRCAAA MEME-3 regular expression -------------------------------------------------------------------------------- TC[AT][AG]CAAA -------------------------------------------------------------------------------- Time 3.86 secs. ******************************************************************************** ******************************************************************************** MOTIF AAAAKTAG MEME-4 width = 8 sites = 4 llr = 42 E-value = 5.0e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAAAKTAG MEME-4 Description -------------------------------------------------------------------------------- Simplified A 8aa8:3a: pos.-specific C :::::::: probability G ::::5::8 matrix T 3::358:3 bits 2.6 ** * 2.3 ** * 2.1 ** * 1.8 **** ** Relative 1.5 **** ** Entropy 1.3 **** ** (15.0 bits) 1.0 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel AAAAGTAG consensus T TTA T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAAKTAG MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr11:119155480-11915550 12 2.07e-06 TGGTGACACA AAAATTAT T chr12:54582894-54582914 2 9.94e-06 C TAAATTAG CCCTAAAGAT chr7:130692414-130692434 1 1.96e-05 . AAAAGAAG AGGAGGAGGA chr9:102861350-102861370 3 1.96e-05 GG AAATGTAG TCCTGCACTA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAAKTAG MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr11:119155480-11915550 2.1e-06 11_[+4]_1 chr12:54582894-54582914 9.9e-06 1_[+4]_11 chr7:130692414-130692434 2e-05 [+4]_12 chr9:102861350-102861370 2e-05 2_[+4]_10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAAKTAG MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAAAKTAG width=8 seqs=4 chr11:119155480-11915550 ( 12) AAAATTAT 1 chr12:54582894-54582914 ( 2) TAAATTAG 1 chr7:130692414-130692434 ( 1) AAAAGAAG 1 chr9:102861350-102861370 ( 3) AAATGTAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAAKTAG MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.4021 E= 5.0e+002 214 -865 -865 52 256 -865 -865 -865 256 -865 -865 -865 214 -865 -865 52 -865 -865 64 152 56 -865 -865 210 256 -865 -865 -865 -865 -865 122 52 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAAKTAG MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 5.0e+002 0.750000 0.000000 0.000000 0.250000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.750000 0.000000 0.000000 0.250000 0.000000 0.000000 0.500000 0.500000 0.250000 0.000000 0.000000 0.750000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.750000 0.250000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAAKTAG MEME-4 regular expression -------------------------------------------------------------------------------- [AT]AA[AT][GT][TA]A[GT] -------------------------------------------------------------------------------- Time 7.04 secs. ******************************************************************************** ******************************************************************************** MOTIF CASGTGAC MEME-5 width = 8 sites = 9 llr = 80 E-value = 1.4e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif CASGTGAC MEME-5 Description -------------------------------------------------------------------------------- Simplified A :a:1::a: pos.-specific C a:7::::7 probability G ::38:a:2 matrix T :::1a::1 bits 2.6 * * * 2.3 * * * 2.1 * * * 1.8 * * * Relative 1.5 ** *** Entropy 1.3 ** *** (12.9 bits) 1.0 ** *** 0.8 ******* 0.5 ******** 0.3 ******** 0.0 -------- Multilevel CACGTGAC consensus G G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CASGTGAC MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr20:2821317-2821337 8 1.94e-05 GCCTCGC CACGTGAC CCGGA chr10:46222629-46222649 11 1.94e-05 CGGGTTCTGT CACGTGAC AT chrX:15873151-15873171 12 1.94e-05 GAAGCCGGGC CACGTGAC C chr16:69796194-69796214 4 3.80e-05 GGT CAGGTGAC CGCGCGCGG chr6:158981087-158981107 9 6.66e-05 CTTCCGCG CACGTGAT CTCG chr1:155211070-155211090 12 8.74e-05 CTAGGAGCGT CACATGAC A chr5:93447388-93447408 3 8.74e-05 CG CACTTGAC GGCAGCGGCG chr12:57984983-57985003 10 1.05e-04 ACAGCAGCG CAGGTGAG CGC chr16:30546338-30546358 12 1.05e-04 CCGGCCCCGC CAGGTGAG G -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CASGTGAC MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr20:2821317-2821337 1.9e-05 7_[+5]_5 chr10:46222629-46222649 1.9e-05 10_[+5]_2 chrX:15873151-15873171 1.9e-05 11_[+5]_1 chr16:69796194-69796214 3.8e-05 3_[+5]_9 chr6:158981087-158981107 6.7e-05 8_[+5]_4 chr1:155211070-155211090 8.7e-05 11_[+5]_1 chr5:93447388-93447408 8.7e-05 2_[+5]_10 chr12:57984983-57985003 0.00011 9_[+5]_3 chr16:30546338-30546358 0.00011 11_[+5]_1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CASGTGAC MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CASGTGAC width=8 seqs=9 chr20:2821317-2821337 ( 8) CACGTGAC 1 chr10:46222629-46222649 ( 11) CACGTGAC 1 chrX:15873151-15873171 ( 12) CACGTGAC 1 chr16:69796194-69796214 ( 4) CAGGTGAC 1 chr6:158981087-158981107 ( 9) CACGTGAT 1 chr1:155211070-155211090 ( 12) CACATGAC 1 chr5:93447388-93447408 ( 3) CACTTGAC 1 chr12:57984983-57985003 ( 10) CAGGTGAG 1 chr16:30546338-30546358 ( 12) CAGGTGAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CASGTGAC MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.62696 E= 1.4e+003 -982 157 -982 -982 256 -982 -982 -982 -982 99 6 -982 -61 -982 128 -65 -982 -982 -982 252 -982 -982 164 -982 256 -982 -982 -982 -982 99 -53 -65 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CASGTGAC MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 9 E= 1.4e+003 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.333333 0.000000 0.111111 0.000000 0.777778 0.111111 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.222222 0.111111 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CASGTGAC MEME-5 regular expression -------------------------------------------------------------------------------- CA[CG]GTGA[CG] -------------------------------------------------------------------------------- Time 9.65 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:241500609-241500629 3.84e-01 20 chr1:231473708-231473728 1.78e-02 20 chr20:33735165-33735185 5.50e-02 20 chr17:80408669-80408689 2.20e-01 20 chr9:68726423-68726443 2.70e-01 20 chr9:97021568-97021588 6.13e-01 20 chr5:93447388-93447408 2.01e-02 2_[+5(8.74e-05)]_10 chr9:69065466-69065486 5.30e-03 3_[+2(1.77e-05)]_9 chr19:53073548-53073568 7.78e-01 20 chr16:67193801-67193821 4.25e-01 20 chr19:53837001-53837021 8.10e-02 20 chr19:53360841-53360861 2.35e-01 20 chr7:98923492-98923512 1.28e-02 3_[+1(2.00e-05)]_9 chr16:88877905-88877925 8.54e-01 20 chr11:114271313-11427133 4.75e-02 20 chr19:53898403-53898423 9.97e-02 20 chr21:34100327-34100347 8.18e-01 20 chr12:54582894-54582914 1.17e-02 1_[+4(9.94e-06)]_11 chr6:8435772-8435792 7.70e-01 20 chr8:21776026-21776046 1.06e-02 9_[+3(1.59e-05)]_3 chr17:7358856-7358876 7.86e-03 20 chr10:16859704-16859724 8.62e-01 20 chr16:69796194-69796214 3.39e-02 3_[+5(3.80e-05)]_9 chr8:144623767-144623787 6.48e-01 20 chr10:124134070-12413409 9.04e-02 20 chr3:195681431-195681451 8.63e-01 20 chr8:10874064-10874084 9.53e-01 20 chr10:74870195-74870215 2.45e-03 5_[+2(9.48e-05)]_7 chr1:22755273-22755293 2.45e-01 20 chr1:231376914-231376934 9.08e-01 20 chrX:15873151-15873171 5.59e-02 11_[+5(1.94e-05)]_1 chr20:37678854-37678874 5.33e-02 1_[+1(2.00e-05)]_11 chr16:77225035-77225055 7.77e-01 20 chr19:53238289-53238309 4.23e-01 20 chr7:111846557-111846577 7.07e-01 20 chr19:1174251-1174271 9.09e-01 20 chr5:85913685-85913705 2.58e-01 20 chrX:155110941-155110961 2.04e-01 20 chr19:2042305-2042325 7.04e-02 20 chr20:2082860-2082880 4.32e-01 20 chr15:55611345-55611365 5.66e-01 20 chr3:119419546-119419566 1.98e-02 3_[+1(3.08e-05)]_9 chr2:113342000-113342020 8.52e-04 12_[+2(1.77e-05)] chr16:30546338-30546358 1.14e-01 20 chr12:64616060-64616080 2.34e-02 3_[+1(2.00e-05)]_9 chr6:43149860-43149880 3.16e-01 20 chr17:4046318-4046338 3.71e-01 20 chr17:34957996-34958016 6.96e-01 20 chr15:91565844-91565864 7.88e-01 20 chr21:17104793-17104813 2.51e-03 12_[+2(4.52e-05)] chr1:16302582-16302602 5.69e-01 20 chr9:99329249-99329269 6.02e-01 20 chr10:46222629-46222649 1.30e-02 10_[+5(1.94e-05)]_2 chr16:15150047-15150067 9.75e-03 10_[+2(4.52e-05)]_2 chr19:7459982-7460002 7.74e-01 20 chrX:47518538-47518558 5.65e-01 20 chrX:48432717-48432737 1.36e-01 20 chr17:37886755-37886775 9.17e-01 20 chr4:10118473-10118493 4.25e-01 20 chr3:3168605-3168625 3.97e-01 20 chr9:102861350-102861370 1.14e-02 2_[+4(1.96e-05)]_10 chr10:126150286-12615030 1.70e-01 20 chr18:55297510-55297530 5.76e-01 20 chr11:124492753-12449277 7.02e-02 20 chr17:38375473-38375493 7.21e-01 20 chr9:127962738-127962758 9.19e-02 20 chr19:41082745-41082765 5.64e-01 20 chr20:48429405-48429425 7.58e-01 20 chr9:128024008-128024028 9.12e-01 20 chr7:97601661-97601681 1.41e-01 20 chr12:57984983-57985003 3.46e-02 20 chr1:155211070-155211090 4.96e-02 11_[+5(8.74e-05)]_1 chr9:130548291-130548311 1.44e-02 10_[+2(1.77e-05)]_2 chr8:22526631-22526651 1.84e-01 20 chr6:45345829-45345849 5.44e-02 4_[+1(8.98e-05)]_8 chr19:53606666-53606686 6.00e-01 20 chr3:130745659-130745679 9.12e-01 20 chr17:48075806-48075826 1.34e-01 20 chr12:112123797-11212381 1.93e-01 20 chr2:48667911-48667931 9.37e-01 20 chr11:69490124-69490144 9.82e-01 20 chr19:6863677-6863697 1.62e-01 20 chr6:89673350-89673370 4.08e-01 20 chr16:2723568-2723588 7.61e-01 20 chr14:59951149-59951169 6.25e-01 20 chr2:55459518-55459538 9.51e-02 20 chr1:24117581-24117601 1.78e-01 20 chr19:36208596-36208616 9.85e-01 20 chr6:3069182-3069202 9.67e-03 10_[+2(3.63e-05)]_2 chr13:79233272-79233292 2.83e-03 8_[+2(3.63e-05)]_4 chr17:80163939-80163959 8.30e-03 12_[+1(6.88e-05)] chr17:18684534-18684554 1.65e-01 20 chr16:28936502-28936522 6.39e-01 20 chr18:21083390-21083410 5.73e-01 20 chr9:32552290-32552310 1.72e-01 20 chr19:18133071-18133091 1.65e-01 20 chr11:70049332-70049352 8.31e-01 20 chr2:210867263-210867283 1.37e-01 20 chr1:1655842-1655862 2.73e-02 8_[+1(3.08e-05)]_4 chr19:58361175-58361195 3.20e-02 20 chr19:53445794-53445814 9.73e-01 20 chr6:88412118-88412138 9.52e-02 20 chr15:74392576-74392596 2.38e-01 20 chr5:6378654-6378674 2.24e-01 20 chr20:43595072-43595092 7.64e-01 20 chr2:101179357-101179377 9.44e-01 20 chr6:158981087-158981107 1.70e-02 8_[+5(6.66e-05)]_4 chr12:1800091-1800111 6.33e-01 20 chr19:14800840-14800860 8.07e-01 20 chr6:24721505-24721525 3.52e-03 9_[+3(5.50e-06)]_3 chr12:108908941-10890896 5.85e-01 20 chr19:44576217-44576237 4.57e-01 20 chr8:21966971-21966991 9.20e-01 20 chr6:109804412-109804432 5.10e-01 20 chr8:681229-681249 9.40e-01 20 chr11:47736934-47736954 7.63e-02 20 chr20:2821317-2821337 4.58e-02 7_[+5(1.94e-05)]_5 chr17:62833327-62833347 6.73e-01 20 chr7:72722841-72722861 1.30e-02 4_[+1(2.00e-05)]_8 chr2:198318109-198318129 6.90e-01 20 chr1:24127396-24127416 9.33e-01 20 chr6:37786761-37786781 1.22e-01 20 chr1:235324574-235324594 2.87e-02 11_[+1(2.00e-05)]_1 chr9:139258251-139258271 2.28e-01 20 chr17:79269084-79269104 9.96e-01 20 chr11:64052991-64053011 6.98e-01 20 chr7:99613168-99613188 9.26e-01 20 chr3:194304707-194304727 1.46e-01 20 chr4:166128717-166128737 9.81e-01 20 chr1:107599248-107599268 8.17e-02 20 chr4:6576920-6576940 9.57e-01 20 chr8:18067592-18067612 6.06e-03 20 chr20:18774669-18774689 1.91e-01 20 chr2:3381628-3381648 2.01e-02 20 chr19:57998989-57999009 5.00e-02 20 chr10:27531085-27531105 1.66e-03 2_[+1(6.88e-05)]_10 chr22:24093355-24093375 5.98e-01 20 chr1:200589928-200589948 2.68e-01 20 chr1:172413213-172413233 3.25e-02 4_[+1(2.00e-05)]_8 chr11:94801897-94801917 1.96e-01 20 chr3:48701610-48701630 4.00e-01 20 chr19:44556026-44556046 5.07e-01 20 chr22:41986095-41986115 7.22e-03 [+2(4.52e-05)]_12 chr17:73452611-73452631 3.74e-02 20 chr15:57998879-57998899 7.67e-01 20 chr19:38826391-38826411 1.31e-02 11_[+3(1.59e-05)]_1 chr17:35306197-35306217 5.42e-01 20 chr19:44669168-44669188 9.00e-02 20 chr20:1373829-1373849 1.35e-01 20 chr16:29937517-29937537 1.83e-01 20 chr6:71377477-71377497 1.00e+00 20 chr11:66112582-66112602 5.68e-01 20 chr19:58892685-58892705 2.41e-01 20 chr11:36531800-36531820 2.50e-01 20 chr6:8064754-8064774 6.70e-01 20 chr2:242626403-242626423 1.25e-01 5_[+1(6.88e-05)]_7 chr16:14724102-14724122 4.45e-05 3_[+1(2.00e-05)]_9 chr19:54024127-54024147 6.68e-01 20 chr12:64798086-64798106 9.95e-01 20 chr5:162932551-162932571 7.12e-02 20 chr11:119155480-11915550 4.36e-04 11_[+4(2.07e-06)]_1 chr19:58427997-58428017 1.38e-02 20 chr16:3508000-3508020 2.02e-01 20 chr12:125473662-12547368 3.38e-02 4_[+1(2.00e-05)]_8 chr7:157129642-157129662 9.85e-01 20 chr9:34458570-34458590 2.51e-02 7_[+1(2.00e-05)]_5 chr11:59436588-59436608 3.15e-01 20 chr5:60458282-60458302 2.88e-02 12_[+2(3.63e-05)] chr1:23694886-23694906 7.89e-02 20 chr1:36851671-36851691 3.47e-01 20 chr7:130692414-130692434 3.57e-03 [+4(1.96e-05)]_12 chr18:55289117-55289137 8.63e-01 20 chr1:118472312-118472332 3.62e-02 20 chr2:128458972-128458992 4.22e-02 [+1(8.98e-05)]_12 chr10:119806398-11980641 9.43e-01 20 chr1:33116155-33116175 2.50e-01 20 chr5:140079871-140079891 9.34e-01 20 chr7:39989825-39989845 3.48e-01 20 chr2:243030820-243030840 9.26e-01 20 chr11:9336384-9336404 3.13e-01 20 chr1:110036729-110036749 5.35e-01 20 chr17:33446870-33446890 1.26e-01 3_[+1(6.88e-05)]_9 chr1:40942857-40942877 2.09e-01 20 chr17:47022197-47022217 3.03e-01 20 chr19:41284130-41284150 9.37e-01 20 chr8:87520952-87520972 3.01e-01 20 chr1:22379119-22379139 3.30e-02 [+1(8.98e-05)]_12 chr11:65655963-65655983 6.29e-01 20 chr2:196933619-196933639 5.76e-01 20 chrX:40506903-40506923 9.71e-01 20 chr7:6121127-6121147 1.15e-02 4_[+2(5.45e-05)]_8 chr6:43543826-43543846 4.77e-01 20 chr7:100895587-100895607 5.43e-01 20 chr19:18668671-18668691 9.93e-01 20 chr22:38577851-38577871 8.81e-01 20 chrX:69353715-69353735 7.19e-01 20 chr16:89557292-89557312 8.24e-01 20 chr19:56632881-56632901 7.73e-01 20 chr7:23636932-23636952 7.22e-01 20 chr19:38397727-38397747 1.20e-01 20 chr11:45939436-45939456 1.03e-01 4_[+1(6.88e-05)]_8 chr4:2470770-2470790 2.20e-03 [+2(5.45e-05)]_12 chr9:33264950-33264970 9.45e-03 20 chr9:130700154-130700174 1.49e-01 20 chr11:64107636-64107656 7.88e-01 20 chr5:16465890-16465910 4.88e-02 2_[+1(3.08e-05)]_10 chr19:19496559-19496579 8.49e-01 20 chr6:147523630-147523650 1.15e-02 20 chr17:8093597-8093617 2.29e-02 12_[+2(6.39e-05)] chr17:406362-406382 3.41e-02 12_[+1(6.88e-05)] chr1:52499478-52499498 4.94e-01 20 chr1:40283143-40283163 1.80e-03 1_[+2(4.52e-05)]_11 chr8:67525799-67525819 6.46e-01 20 chr17:17936939-17936959 9.46e-03 7_[+2(6.86e-05)]_5 chr3:75834719-75834739 9.24e-02 20 chr17:16439130-16439150 9.17e-01 20 chr7:99102801-99102821 1.23e-01 20 chr2:136499176-136499196 8.64e-01 20 chr16:4524675-4524695 2.77e-01 20 chr4:83812409-83812429 4.97e-01 20 chr12:94071100-94071120 1.60e-03 10_[+3(5.50e-06)]_2 chr19:55629177-55629197 3.33e-02 20 chr17:40688154-40688174 1.32e-01 20 chr17:40346523-40346543 2.80e-02 20 chr11:61197555-61197575 9.06e-01 20 chr15:78832715-78832735 1.39e-01 2_[+1(8.98e-05)]_10 chr15:36871714-36871734 4.15e-01 20 chr2:69870946-69870966 9.95e-01 20 chr12:112856653-11285667 9.27e-01 20 chr19:52772826-52772846 4.28e-01 20 chr22:30234257-30234277 2.54e-01 20 chr7:1199892-1199912 9.55e-01 20 chr9:101018114-101018134 2.35e-01 20 chr6:108395925-108395945 6.11e-02 1_[+1(6.88e-05)]_11 chr18:61089791-61089811 8.33e-01 20 chr8:11141912-11141932 1.29e-01 4_[+1(8.98e-05)]_8 chr1:59282137-59282157 3.00e-02 3_[+1(3.08e-05)]_9 chr11:67030350-67030370 3.10e-03 5_[+2(1.77e-05)]_7 chr7:38948795-38948815 1.30e-03 20 chr19:19626980-19627000 3.51e-01 20 chr22:32146139-32146159 9.76e-01 20 chr17:72772514-72772534 4.54e-02 9_[+1(8.98e-05)]_3 chr19:53289991-53290011 5.49e-01 20 chr7:6865943-6865963 4.89e-04 7_[+4(2.78e-05)]_5 chr1:16693565-16693585 6.18e-01 20 chr16:31470699-31470719 1.48e-01 20 chr8:6264082-6264102 7.14e-01 20 chr12:62860564-62860584 3.07e-01 20 chr9:35604161-35604181 4.72e-01 20 chr20:55043671-55043691 6.49e-03 [+2(1.77e-05)]_12 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n10.farnam.hpc.yale.internal ********************************************************************************