******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/EBF1.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr21:39073183-39073203 1.0000 20 chr1:233088834-233088854 1.0000 20 chr7:151451348-151451368 1.0000 20 chr11:5145456-5145476 1.0000 20 chr11:69485190-69485210 1.0000 20 chr3:184187335-184187355 1.0000 20 chr20:39594899-39594919 1.0000 20 chr13:36295231-36295251 1.0000 20 chr22:29871750-29871770 1.0000 20 chr10:6690063-6690083 1.0000 20 chr20:7075235-7075255 1.0000 20 chr11:65407829-65407849 1.0000 20 chr1:212360108-212360128 1.0000 20 chr11:20044307-20044327 1.0000 20 chr1:224238690-224238710 1.0000 20 chr22:39780968-39780988 1.0000 20 chr15:101947816-10194783 1.0000 20 chr2:204553678-204553698 1.0000 20 chr17:9828247-9828267 1.0000 20 chr3:48236093-48236113 1.0000 20 chr1:44784105-44784125 1.0000 20 chr3:69373729-69373749 1.0000 20 chr7:148272834-148272854 1.0000 20 chr2:7567573-7567593 1.0000 20 chr16:84697520-84697540 1.0000 20 chr7:139593975-139593995 1.0000 20 chr2:6913415-6913435 1.0000 20 chr10:92737399-92737419 1.0000 20 chr3:149732710-149732730 1.0000 20 chr9:140162580-140162600 1.0000 20 chr6:97243010-97243030 1.0000 20 chr2:75904578-75904598 1.0000 20 chr21:32509296-32509316 1.0000 20 chr16:18980745-18980765 1.0000 20 chr12:110809363-11080938 1.0000 20 chr18:46305236-46305256 1.0000 20 chr4:1901165-1901185 1.0000 20 chr19:42618314-42618334 1.0000 20 chr19:50411442-50411462 1.0000 20 chr17:62067963-62067983 1.0000 20 chr10:75856717-75856737 1.0000 20 chr2:42523533-42523553 1.0000 20 chr17:38480370-38480390 1.0000 20 chr5:153900689-153900709 1.0000 20 chr16:9023384-9023404 1.0000 20 chr6:15254436-15254456 1.0000 20 chr1:92864818-92864838 1.0000 20 chr8:22776139-22776159 1.0000 20 chr11:108525895-10852591 1.0000 20 chr21:47674308-47674328 1.0000 20 chr16:88991825-88991845 1.0000 20 chr12:104914529-10491454 1.0000 20 chr15:53027820-53027840 1.0000 20 chr2:27631103-27631123 1.0000 20 chr4:56275840-56275860 1.0000 20 chr2:207019074-207019094 1.0000 20 chr22:30787262-30787282 1.0000 20 chr14:70060228-70060248 1.0000 20 chr17:16884253-16884273 1.0000 20 chr4:159973667-159973687 1.0000 20 chr18:74695415-74695435 1.0000 20 chr12:23358288-23358308 1.0000 20 chr22:22146074-22146094 1.0000 20 chr6:144673635-144673655 1.0000 20 chr17:70385456-70385476 1.0000 20 chr10:71476908-71476928 1.0000 20 chr3:184135822-184135842 1.0000 20 chr19:8009298-8009318 1.0000 20 chr11:65097569-65097589 1.0000 20 chr2:65165264-65165284 1.0000 20 chr7:27962716-27962736 1.0000 20 chr5:71748179-71748199 1.0000 20 chr7:150452741-150452761 1.0000 20 chr5:131693805-131693825 1.0000 20 chr1:43823886-43823906 1.0000 20 chr21:37608837-37608857 1.0000 20 chr21:46524635-46524655 1.0000 20 chr18:33047791-33047811 1.0000 20 chr5:95157866-95157886 1.0000 20 chr2:38209446-38209466 1.0000 20 chr2:206544891-206544911 1.0000 20 chr6:3746665-3746685 1.0000 20 chr12:6649517-6649537 1.0000 20 chr11:120644459-12064447 1.0000 20 chr5:169733523-169733543 1.0000 20 chr1:202134032-202134052 1.0000 20 chr7:148724215-148724235 1.0000 20 chr14:50514258-50514278 1.0000 20 chr6:6333401-6333421 1.0000 20 chr5:37184992-37185012 1.0000 20 chr22:22465541-22465561 1.0000 20 chr2:171669396-171669416 1.0000 20 chr6:74160991-74161011 1.0000 20 chr12:29879074-29879094 1.0000 20 chr3:45951205-45951225 1.0000 20 chr4:104012984-104013004 1.0000 20 chr12:11933595-11933615 1.0000 20 chr12:11716957-11716977 1.0000 20 chr1:25250202-25250222 1.0000 20 chr21:42741511-42741531 1.0000 20 chr7:95083947-95083967 1.0000 20 chr2:25622583-25622603 1.0000 20 chr17:18761254-18761274 1.0000 20 chr12:1771197-1771217 1.0000 20 chr11:76385770-76385790 1.0000 20 chr6:2733634-2733654 1.0000 20 chr11:64645052-64645072 1.0000 20 chr9:88861880-88861900 1.0000 20 chr5:131836978-131836998 1.0000 20 chrX:73726518-73726538 1.0000 20 chr5:168307092-168307112 1.0000 20 chr12:54591576-54591596 1.0000 20 chr1:203142884-203142904 1.0000 20 chr16:15850158-15850178 1.0000 20 chr2:200511324-200511344 1.0000 20 chr10:71867303-71867323 1.0000 20 chr22:24142676-24142696 1.0000 20 chr1:200986625-200986645 1.0000 20 chr8:103952709-103952729 1.0000 20 chr1:26869804-26869824 1.0000 20 chr10:45916017-45916037 1.0000 20 chr5:7794560-7794580 1.0000 20 chr1:207995676-207995696 1.0000 20 chr12:131455335-13145535 1.0000 20 chr13:78775726-78775746 1.0000 20 chr19:949303-949323 1.0000 20 chr13:61821947-61821967 1.0000 20 chr1:17421311-17421331 1.0000 20 chr10:32043109-32043129 1.0000 20 chr5:152860161-152860181 1.0000 20 chr17:16190407-16190427 1.0000 20 chr1:211870870-211870890 1.0000 20 chr15:70796706-70796726 1.0000 20 chr17:53514896-53514916 1.0000 20 chr12:57856626-57856646 1.0000 20 chr14:77371438-77371458 1.0000 20 chr4:38762716-38762736 1.0000 20 chr21:30638614-30638634 1.0000 20 chr22:28315489-28315509 1.0000 20 chr19:51208923-51208943 1.0000 20 chr16:56922916-56922936 1.0000 20 chr16:75186725-75186745 1.0000 20 chr19:2332554-2332574 1.0000 20 chr17:7994521-7994541 1.0000 20 chr14:75689017-75689037 1.0000 20 chr1:118077681-118077701 1.0000 20 chr19:45274066-45274086 1.0000 20 chr2:62369375-62369395 1.0000 20 chr6:44706442-44706462 1.0000 20 chr21:37885921-37885941 1.0000 20 chr5:68036249-68036269 1.0000 20 chr21:43804463-43804483 1.0000 20 chr4:7256613-7256633 1.0000 20 chr3:52057996-52058016 1.0000 20 chr15:44838762-44838782 1.0000 20 chr19:7410892-7410912 1.0000 20 chr5:149036353-149036373 1.0000 20 chr13:33365940-33365960 1.0000 20 chrX:40399192-40399212 1.0000 20 chr14:52294850-52294870 1.0000 20 chr21:34753034-34753054 1.0000 20 chr2:96822931-96822951 1.0000 20 chr1:32803123-32803143 1.0000 20 chr10:82349782-82349802 1.0000 20 chr8:141709574-141709594 1.0000 20 chr8:61681166-61681186 1.0000 20 chr16:89041274-89041294 1.0000 20 chr3:171515313-171515333 1.0000 20 chr12:133532415-13353243 1.0000 20 chr1:109655467-109655487 1.0000 20 chr16:11403823-11403843 1.0000 20 chr11:133415155-13341517 1.0000 20 chr12:131724475-13172449 1.0000 20 chr22:22110357-22110377 1.0000 20 chr5:131721205-131721225 1.0000 20 chr14:71130546-71130566 1.0000 20 chr14:51670109-51670129 1.0000 20 chr19:4375829-4375849 1.0000 20 chr14:105491319-10549133 1.0000 20 chr9:33202709-33202729 1.0000 20 chr8:28911820-28911840 1.0000 20 chr9:102272288-102272308 1.0000 20 chr8:52308915-52308935 1.0000 20 chr14:65787758-65787778 1.0000 20 chr22:40295243-40295263 1.0000 20 chr7:156333519-156333539 1.0000 20 chr19:7884409-7884429 1.0000 20 chr2:158301280-158301300 1.0000 20 chr14:70706696-70706716 1.0000 20 chr20:11242435-11242455 1.0000 20 chr10:82359243-82359263 1.0000 20 chr3:9732939-9732959 1.0000 20 chr1:8703811-8703831 1.0000 20 chr11:36377949-36377969 1.0000 20 chr6:36721067-36721087 1.0000 20 chr12:10875307-10875327 1.0000 20 chr9:92450442-92450462 1.0000 20 chr11:64442481-64442501 1.0000 20 chr18:35110009-35110029 1.0000 20 chr11:45392937-45392957 1.0000 20 chr2:74212785-74212805 1.0000 20 chr15:33615975-33615995 1.0000 20 chr11:46324659-46324679 1.0000 20 chr6:7239255-7239275 1.0000 20 chr1:28503857-28503877 1.0000 20 chr3:10334638-10334658 1.0000 20 chr3:27722911-27722931 1.0000 20 chr1:2487461-2487481 1.0000 20 chr12:86907751-86907771 1.0000 20 chr10:1704221-1704241 1.0000 20 chr22:36146001-36146021 1.0000 20 chr19:36050375-36050395 1.0000 20 chr3:49843065-49843085 1.0000 20 chr19:6088030-6088050 1.0000 20 chr9:131406160-131406180 1.0000 20 chr5:168843970-168843990 1.0000 20 chr2:6966775-6966795 1.0000 20 chr10:1020243-1020263 1.0000 20 chr20:34205685-34205705 1.0000 20 chr1:52498534-52498554 1.0000 20 chr1:31223821-31223841 1.0000 20 chr12:12164996-12165016 1.0000 20 chr16:15859958-15859978 1.0000 20 chr9:136811164-136811184 1.0000 20 chr1:66868086-66868106 1.0000 20 chr6:36749662-36749682 1.0000 20 chr10:60756804-60756824 1.0000 20 chr15:73928934-73928954 1.0000 20 chr2:220024990-220025010 1.0000 20 chr5:180402474-180402494 1.0000 20 chrX:19881814-19881834 1.0000 20 chrX:78515101-78515121 1.0000 20 chr14:100403691-10040371 1.0000 20 chr10:73528731-73528751 1.0000 20 chr9:35619966-35619986 1.0000 20 chr15:101696938-10169695 1.0000 20 chr1:222014006-222014026 1.0000 20 chr6:89203671-89203691 1.0000 20 chr2:85097644-85097664 1.0000 20 chr7:114571953-114571973 1.0000 20 chr13:31018190-31018210 1.0000 20 chr4:2939177-2939197 1.0000 20 chr11:7495156-7495176 1.0000 20 chr9:124260542-124260562 1.0000 20 chr18:46250406-46250426 1.0000 20 chr9:85911209-85911229 1.0000 20 chr3:32478521-32478541 1.0000 20 chr1:245103691-245103711 1.0000 20 chr14:93479782-93479802 1.0000 20 chr8:70725804-70725824 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_EBF1/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/EBF1.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.199 C 0.288 G 0.298 T 0.215 Background letter frequencies (from file dataset with add-one prior applied): A 0.199 C 0.288 G 0.298 T 0.215 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF CCCWGGGR MEME-1 width = 8 sites = 100 llr = 669 E-value = 1.4e-085 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCCWGGGR MEME-1 Description -------------------------------------------------------------------------------- Simplified A ::15:215 pos.-specific C a98::::: probability G :::1a995 matrix T 1115:::: bits 2.3 2.1 1.9 1.6 * * Relative 1.4 ** * * Entropy 1.2 ** *** (9.7 bits) 0.9 ******* 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CCCTGGGA consensus A G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCWGGGR MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr15:101696938-10169695 1 2.70e-05 . ccctggga ctgggcttcc chr1:31223821-31223841 11 2.70e-05 GGGTGGGGTC CCCTGGGA AA chr3:10334638-10334658 2 2.70e-05 C CCCTGGGA GTTGGAAACT chr6:7239255-7239275 9 2.70e-05 CCTCCTTC CCCTGGGA AAAC chr17:53514896-53514916 3 2.70e-05 TC CCCTGGGA CATGCTAAGT chr3:184135822-184135842 7 2.70e-05 GCGCTC CCCTGGGA ACGGTT chr4:56275840-56275860 4 2.70e-05 gtc ccctggga gacaaaatc chr1:66868086-66868106 5 5.21e-05 GGTC CCCAGGGA CACCAGTG chr20:34205685-34205705 11 5.21e-05 CCTCCGGTTC CCCAGGGA GG chr10:1704221-1704241 11 5.21e-05 CCCAGGAGTc cccaggga gg chr19:7410892-7410912 4 5.21e-05 GTC CCCAGGGA CAAGCGCGG chr3:52057996-52058016 7 5.21e-05 CAGGTC CCCAGGGA GGGGAT chr17:18761254-18761274 2 5.21e-05 C CCCAGGGA CCAAAACAGG chr5:169733523-169733543 13 5.21e-05 TTCATCCCTC CCCAGGGA chr5:95157866-95157886 11 5.21e-05 TAGATAATTC CCCAGGGA CT chr22:22146074-22146094 1 5.21e-05 . cccaggga acaaCAGGAC chr12:110809363-11080938 8 5.21e-05 CCAGCTC CCCAGGGA GGCCT chrX:78515101-78515121 8 9.26e-05 TGTGGGT CCCTGGGG ACTCA chr12:10875307-10875327 12 9.26e-05 ACCCGGAGAT CCCTGGGG A chr10:82359243-82359263 3 9.26e-05 AT CCCTGGGG GCTTTATGGT chr22:40295243-40295263 13 9.26e-05 ATATTCTGCT CCCTGGGG chr14:65787758-65787778 10 9.26e-05 CTTACAAGT CCCTGGGG AAT chr16:89041274-89041294 3 9.26e-05 GC CCCTGGGG TACAGGATGA chr2:62369375-62369395 9 9.26e-05 TACTCCCT CCCTGGGG AGTT chr17:16190407-16190427 6 9.26e-05 TGGGT CCCTGGGG ACCCCTC chr10:32043109-32043129 1 9.26e-05 . ccctgggg acatggggca chr1:17421311-17421331 6 9.26e-05 TGTCG CCCTGGGG CTGCTGG chr10:71867303-71867323 10 9.26e-05 GAACTGCTC CCCTGGGG AGT chr12:11933595-11933615 2 9.26e-05 T CCCTGGGG AATTGGTCAC chr5:131693805-131693825 5 9.26e-05 GCTC CCCTGGGG CTTAGCCC chr7:27962716-27962736 1 9.26e-05 . CCCTGGGG ACTCTGGTGA chr2:42523533-42523553 5 9.26e-05 TTTC CCCTGGGG ATTGGCAG chr19:42618314-42618334 8 9.26e-05 GCTGGGT CCCTGGGG AGCTG chr18:46305236-46305256 4 9.26e-05 GGT CCCTGGGG AGCCCAGAA chr13:36295231-36295251 3 9.26e-05 GT CCCTGGGG ACTGGGATGA chr6:89203671-89203691 3 1.30e-04 tc cccagggg acatccagca chr8:28911820-28911840 9 1.30e-04 CTTCAGGC CCCAGGGG ACTC chr14:71130546-71130566 12 1.30e-04 TCTCTTTCTC CCCAGGGG C chr14:52294850-52294870 10 1.30e-04 GCCATCATC CCCAGGGG AGC chr17:7994521-7994541 13 1.30e-04 GCCCTGTGTC CCCAGGGG chr21:30638614-30638634 7 1.30e-04 aacctc cccagggg attcta chrX:73726518-73726538 2 1.30e-04 C CCCAGGGG AGAGACTCAG chr5:131836978-131836998 8 1.30e-04 GGTGCTC CCCAGGGG ATTAG chr12:29879074-29879094 5 1.30e-04 CAGT CCCAGGGG ACACCACC chr9:136811164-136811184 5 1.48e-04 AGTC CCCTGAGA CATTGGTC chr16:15850158-15850178 3 1.48e-04 TC CCCTGAGA CAGAGTCCCC chr3:49843065-49843085 1 2.04e-04 . CCTTGGGA GTGGGCTGTG chrX:40399192-40399212 6 2.04e-04 gtccc ccttggga ctgagcg chr1:200986625-200986645 5 2.04e-04 CCTC CCCAGAGA CAGGAGAC chr1:203142884-203142904 5 2.04e-04 TGTC CCCAGAGA CCTCAGAT chr12:11716957-11716977 2 2.04e-04 c ccatggga cttcttatta chr8:22776139-22776159 7 2.04e-04 GAATTC CCTTGGGA CTGTCC chr6:15254436-15254456 2 2.04e-04 C CCTTGGGA CTGGATGGTT chr11:133415155-13341517 9 2.40e-04 AGGAGGTC CCTAGGGA GGAT chr8:141709574-141709594 1 2.40e-04 . CCAAGGGA CTTCTGAAGT chr21:43804463-43804483 10 2.40e-04 CTCCTGGCC CCTAGGGA CAC chr19:45274066-45274086 5 2.40e-04 GTTC CCAAGGGA GGTGGTAA chr11:76385770-76385790 3 2.40e-04 CC CCAAGGGA GTTGGGGGGA chr2:27631103-27631123 9 2.40e-04 AACAATTC CCAAGGGA GACA chr8:52308915-52308935 1 3.70e-04 . CCCAGAGG CCTTCCCGAC chr13:78775726-78775746 3 3.70e-04 CC CTCTGGGA CTTTCTGTGC chr2:204553678-204553698 4 3.70e-04 GTC CTCTGGGA CAACATCTG chr2:96822931-96822951 6 4.43e-04 AAGCC CTCAGGGA CTTGCTG chr9:85911209-85911229 3 5.08e-04 GT CTCTGGGG AGATTGAGGT chr9:33202709-33202729 13 5.08e-04 ACAGTTTGTC CTCTGGGG chr21:37885921-37885941 13 5.08e-04 GGGACATGCC CTCTGGGG chr21:47674308-47674328 9 5.08e-04 CCACAACT CTCTGGGG ACTG chr6:97243010-97243030 3 5.08e-04 gg cccaggaa tctgtactgt chr1:25250202-25250222 2 5.36e-04 T CTCAGGGG ACCTCGGGGT chr1:28503857-28503877 1 5.83e-04 . CCCTGGAG ACCAAGAAAC chr9:92450442-92450462 11 5.83e-04 TGACACTATC CCCTGGAG AG chr7:156333519-156333539 13 5.83e-04 GGGAGCAGGC CCCTGGAG chr7:139593975-139593995 3 5.83e-04 CC TCCTGGGA CTACCGTGCC chr18:46250406-46250426 1 7.19e-04 . CCCTGGGT GCTTGGTGTA chr15:53027820-53027840 12 7.19e-04 CTCCCTTTTC CCCTGGGT T chr6:36749662-36749682 2 7.71e-04 A CCAAGAGA GGCCCAGATT chr18:35110009-35110029 12 7.71e-04 TTGTATTGTC CCTAGAGA C chr19:7884409-7884429 10 7.71e-04 atcgatccc ccaagaga ctt chr9:131406160-131406180 2 9.24e-04 T CCCGGGGG AGGTCACAAA chr10:1020243-1020263 2 1.01e-03 C CCTTGAGG AGTGTTCCCT chr14:70706696-70706716 6 1.01e-03 AAGTC CCATGAGG ACTGGGG chr1:32803123-32803143 7 1.01e-03 AGACAC CCCAGGGC CTGAGA chr22:22465541-22465561 6 1.01e-03 AATTC CCCAGGGC TGGGCAG chr18:33047791-33047811 9 1.01e-03 CCAGAAGC CCCAGGGC CTGT chr12:54591576-54591596 5 1.09e-03 GGTC CCAAGAGG CTTGGGGG chr11:65407829-65407849 3 1.39e-03 GA CCCTGAAG GAAGTGGGAG chr19:6088030-6088050 13 1.71e-03 GCCACAGTCC TCAAGGGA chr11:36377949-36377969 7 1.71e-03 gaggcc tcaaggga gttgag chr19:949303-949323 1 1.71e-03 . CCTGGGGA GCAGCAGCCG chr7:148724215-148724235 3 1.71e-03 TC TCAAGGGA AAACTGACtt chr2:7567573-7567593 1 1.71e-03 . CCTGGGGA ATTGTCTCTT chr10:6690063-6690083 1 1.71e-03 . CCTGGGGA CGGGAGTGGT chr22:28315489-28315509 12 1.81e-03 CAGCTTTGGT CCCTCGGG G chr1:207995676-207995696 6 1.81e-03 AGTAG CCCAGAGT CAGCAGG chr6:144673635-144673655 12 1.91e-03 CTTTTCATGT CCCACGGG A chr14:77371438-77371458 9 2.10e-03 cttaaggg cactgggg catt chr1:212360108-212360128 9 2.10e-03 GAAGTATT CTCTGGAG ACCA chr22:39780968-39780988 1 2.39e-03 . CCTGGGGG TGTCGCAGTT chr10:73528731-73528751 13 3.39e-03 ctgactactC TCTAGAGA chr6:2733634-2733654 8 3.39e-03 AGCAGAC CTCAGAAA CCAAC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCWGGGR MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr15:101696938-10169695 2.7e-05 [+1]_12 chr1:31223821-31223841 2.7e-05 10_[+1]_2 chr3:10334638-10334658 2.7e-05 1_[+1]_11 chr6:7239255-7239275 2.7e-05 8_[+1]_4 chr17:53514896-53514916 2.7e-05 2_[+1]_10 chr3:184135822-184135842 2.7e-05 6_[+1]_6 chr4:56275840-56275860 2.7e-05 3_[+1]_9 chr1:66868086-66868106 5.2e-05 4_[+1]_8 chr20:34205685-34205705 5.2e-05 10_[+1]_2 chr10:1704221-1704241 5.2e-05 10_[+1]_2 chr19:7410892-7410912 5.2e-05 3_[+1]_9 chr3:52057996-52058016 5.2e-05 6_[+1]_6 chr17:18761254-18761274 5.2e-05 1_[+1]_11 chr5:169733523-169733543 5.2e-05 12_[+1] chr5:95157866-95157886 5.2e-05 10_[+1]_2 chr22:22146074-22146094 5.2e-05 [+1]_12 chr12:110809363-11080938 5.2e-05 7_[+1]_5 chrX:78515101-78515121 9.3e-05 7_[+1]_5 chr12:10875307-10875327 9.3e-05 11_[+1]_1 chr10:82359243-82359263 9.3e-05 2_[+1]_10 chr22:40295243-40295263 9.3e-05 12_[+1] chr14:65787758-65787778 9.3e-05 9_[+1]_3 chr16:89041274-89041294 9.3e-05 2_[+1]_10 chr2:62369375-62369395 9.3e-05 8_[+1]_4 chr17:16190407-16190427 9.3e-05 5_[+1]_7 chr10:32043109-32043129 9.3e-05 [+1]_12 chr1:17421311-17421331 9.3e-05 5_[+1]_7 chr10:71867303-71867323 9.3e-05 9_[+1]_3 chr12:11933595-11933615 9.3e-05 1_[+1]_11 chr5:131693805-131693825 9.3e-05 4_[+1]_8 chr7:27962716-27962736 9.3e-05 [+1]_12 chr2:42523533-42523553 9.3e-05 4_[+1]_8 chr19:42618314-42618334 9.3e-05 7_[+1]_5 chr18:46305236-46305256 9.3e-05 3_[+1]_9 chr13:36295231-36295251 9.3e-05 2_[+1]_10 chr6:89203671-89203691 0.00013 2_[+1]_10 chr8:28911820-28911840 0.00013 8_[+1]_4 chr14:71130546-71130566 0.00013 11_[+1]_1 chr14:52294850-52294870 0.00013 9_[+1]_3 chr17:7994521-7994541 0.00013 12_[+1] chr21:30638614-30638634 0.00013 6_[+1]_6 chrX:73726518-73726538 0.00013 1_[+1]_11 chr5:131836978-131836998 0.00013 7_[+1]_5 chr12:29879074-29879094 0.00013 4_[+1]_8 chr9:136811164-136811184 0.00015 4_[+1]_8 chr16:15850158-15850178 0.00015 2_[+1]_10 chr3:49843065-49843085 0.0002 [+1]_12 chrX:40399192-40399212 0.0002 5_[+1]_7 chr1:200986625-200986645 0.0002 4_[+1]_8 chr1:203142884-203142904 0.0002 4_[+1]_8 chr12:11716957-11716977 0.0002 1_[+1]_11 chr8:22776139-22776159 0.0002 6_[+1]_6 chr6:15254436-15254456 0.0002 1_[+1]_11 chr11:133415155-13341517 0.00024 8_[+1]_4 chr8:141709574-141709594 0.00024 [+1]_12 chr21:43804463-43804483 0.00024 9_[+1]_3 chr19:45274066-45274086 0.00024 4_[+1]_8 chr11:76385770-76385790 0.00024 2_[+1]_10 chr2:27631103-27631123 0.00024 8_[+1]_4 chr8:52308915-52308935 0.00037 [+1]_12 chr13:78775726-78775746 0.00037 2_[+1]_10 chr2:204553678-204553698 0.00037 3_[+1]_9 chr2:96822931-96822951 0.00044 5_[+1]_7 chr9:85911209-85911229 0.00051 2_[+1]_10 chr9:33202709-33202729 0.00051 12_[+1] chr21:37885921-37885941 0.00051 12_[+1] chr21:47674308-47674328 0.00051 8_[+1]_4 chr6:97243010-97243030 0.00051 2_[+1]_10 chr1:25250202-25250222 0.00054 1_[+1]_11 chr1:28503857-28503877 0.00058 [+1]_12 chr9:92450442-92450462 0.00058 10_[+1]_2 chr7:156333519-156333539 0.00058 12_[+1] chr7:139593975-139593995 0.00058 2_[+1]_10 chr18:46250406-46250426 0.00072 [+1]_12 chr15:53027820-53027840 0.00072 11_[+1]_1 chr6:36749662-36749682 0.00077 1_[+1]_11 chr18:35110009-35110029 0.00077 11_[+1]_1 chr19:7884409-7884429 0.00077 9_[+1]_3 chr9:131406160-131406180 0.00092 1_[+1]_11 chr10:1020243-1020263 0.001 1_[+1]_11 chr14:70706696-70706716 0.001 5_[+1]_7 chr1:32803123-32803143 0.001 6_[+1]_6 chr22:22465541-22465561 0.001 5_[+1]_7 chr18:33047791-33047811 0.001 8_[+1]_4 chr12:54591576-54591596 0.0011 4_[+1]_8 chr11:65407829-65407849 0.0014 2_[+1]_10 chr19:6088030-6088050 0.0017 12_[+1] chr11:36377949-36377969 0.0017 6_[+1]_6 chr19:949303-949323 0.0017 [+1]_12 chr7:148724215-148724235 0.0017 2_[+1]_10 chr2:7567573-7567593 0.0017 [+1]_12 chr10:6690063-6690083 0.0017 [+1]_12 chr22:28315489-28315509 0.0018 11_[+1]_1 chr1:207995676-207995696 0.0018 5_[+1]_7 chr6:144673635-144673655 0.0019 11_[+1]_1 chr14:77371438-77371458 0.0021 8_[+1]_4 chr1:212360108-212360128 0.0021 8_[+1]_4 chr22:39780968-39780988 0.0024 [+1]_12 chr10:73528731-73528751 0.0034 12_[+1] chr6:2733634-2733654 0.0034 7_[+1]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCWGGGR MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCCWGGGR width=8 seqs=100 chr15:101696938-10169695 ( 1) CCCTGGGA 1 chr1:31223821-31223841 ( 11) CCCTGGGA 1 chr3:10334638-10334658 ( 2) CCCTGGGA 1 chr6:7239255-7239275 ( 9) CCCTGGGA 1 chr17:53514896-53514916 ( 3) CCCTGGGA 1 chr3:184135822-184135842 ( 7) CCCTGGGA 1 chr4:56275840-56275860 ( 4) CCCTGGGA 1 chr1:66868086-66868106 ( 5) CCCAGGGA 1 chr20:34205685-34205705 ( 11) CCCAGGGA 1 chr10:1704221-1704241 ( 11) CCCAGGGA 1 chr19:7410892-7410912 ( 4) CCCAGGGA 1 chr3:52057996-52058016 ( 7) CCCAGGGA 1 chr17:18761254-18761274 ( 2) CCCAGGGA 1 chr5:169733523-169733543 ( 13) CCCAGGGA 1 chr5:95157866-95157886 ( 11) CCCAGGGA 1 chr22:22146074-22146094 ( 1) CCCAGGGA 1 chr12:110809363-11080938 ( 8) CCCAGGGA 1 chrX:78515101-78515121 ( 8) CCCTGGGG 1 chr12:10875307-10875327 ( 12) CCCTGGGG 1 chr10:82359243-82359263 ( 3) CCCTGGGG 1 chr22:40295243-40295263 ( 13) CCCTGGGG 1 chr14:65787758-65787778 ( 10) CCCTGGGG 1 chr16:89041274-89041294 ( 3) CCCTGGGG 1 chr2:62369375-62369395 ( 9) CCCTGGGG 1 chr17:16190407-16190427 ( 6) CCCTGGGG 1 chr10:32043109-32043129 ( 1) CCCTGGGG 1 chr1:17421311-17421331 ( 6) CCCTGGGG 1 chr10:71867303-71867323 ( 10) CCCTGGGG 1 chr12:11933595-11933615 ( 2) CCCTGGGG 1 chr5:131693805-131693825 ( 5) CCCTGGGG 1 chr7:27962716-27962736 ( 1) CCCTGGGG 1 chr2:42523533-42523553 ( 5) CCCTGGGG 1 chr19:42618314-42618334 ( 8) CCCTGGGG 1 chr18:46305236-46305256 ( 4) CCCTGGGG 1 chr13:36295231-36295251 ( 3) CCCTGGGG 1 chr6:89203671-89203691 ( 3) CCCAGGGG 1 chr8:28911820-28911840 ( 9) CCCAGGGG 1 chr14:71130546-71130566 ( 12) CCCAGGGG 1 chr14:52294850-52294870 ( 10) CCCAGGGG 1 chr17:7994521-7994541 ( 13) CCCAGGGG 1 chr21:30638614-30638634 ( 7) CCCAGGGG 1 chrX:73726518-73726538 ( 2) CCCAGGGG 1 chr5:131836978-131836998 ( 8) CCCAGGGG 1 chr12:29879074-29879094 ( 5) CCCAGGGG 1 chr9:136811164-136811184 ( 5) CCCTGAGA 1 chr16:15850158-15850178 ( 3) CCCTGAGA 1 chr3:49843065-49843085 ( 1) CCTTGGGA 1 chrX:40399192-40399212 ( 6) CCTTGGGA 1 chr1:200986625-200986645 ( 5) CCCAGAGA 1 chr1:203142884-203142904 ( 5) CCCAGAGA 1 chr12:11716957-11716977 ( 2) CCATGGGA 1 chr8:22776139-22776159 ( 7) CCTTGGGA 1 chr6:15254436-15254456 ( 2) CCTTGGGA 1 chr11:133415155-13341517 ( 9) CCTAGGGA 1 chr8:141709574-141709594 ( 1) CCAAGGGA 1 chr21:43804463-43804483 ( 10) CCTAGGGA 1 chr19:45274066-45274086 ( 5) CCAAGGGA 1 chr11:76385770-76385790 ( 3) CCAAGGGA 1 chr2:27631103-27631123 ( 9) CCAAGGGA 1 chr8:52308915-52308935 ( 1) CCCAGAGG 1 chr13:78775726-78775746 ( 3) CTCTGGGA 1 chr2:204553678-204553698 ( 4) CTCTGGGA 1 chr2:96822931-96822951 ( 6) CTCAGGGA 1 chr9:85911209-85911229 ( 3) CTCTGGGG 1 chr9:33202709-33202729 ( 13) CTCTGGGG 1 chr21:37885921-37885941 ( 13) CTCTGGGG 1 chr21:47674308-47674328 ( 9) CTCTGGGG 1 chr6:97243010-97243030 ( 3) CCCAGGAA 1 chr1:25250202-25250222 ( 2) CTCAGGGG 1 chr1:28503857-28503877 ( 1) CCCTGGAG 1 chr9:92450442-92450462 ( 11) CCCTGGAG 1 chr7:156333519-156333539 ( 13) CCCTGGAG 1 chr7:139593975-139593995 ( 3) TCCTGGGA 1 chr18:46250406-46250426 ( 1) CCCTGGGT 1 chr15:53027820-53027840 ( 12) CCCTGGGT 1 chr6:36749662-36749682 ( 2) CCAAGAGA 1 chr18:35110009-35110029 ( 12) CCTAGAGA 1 chr19:7884409-7884429 ( 10) CCAAGAGA 1 chr9:131406160-131406180 ( 2) CCCGGGGG 1 chr10:1020243-1020263 ( 2) CCTTGAGG 1 chr14:70706696-70706716 ( 6) CCATGAGG 1 chr1:32803123-32803143 ( 7) CCCAGGGC 1 chr22:22465541-22465561 ( 6) CCCAGGGC 1 chr18:33047791-33047811 ( 9) CCCAGGGC 1 chr12:54591576-54591596 ( 5) CCAAGAGG 1 chr11:65407829-65407849 ( 3) CCCTGAAG 1 chr19:6088030-6088050 ( 13) TCAAGGGA 1 chr11:36377949-36377969 ( 7) TCAAGGGA 1 chr19:949303-949323 ( 1) CCTGGGGA 1 chr7:148724215-148724235 ( 3) TCAAGGGA 1 chr2:7567573-7567593 ( 1) CCTGGGGA 1 chr10:6690063-6690083 ( 1) CCTGGGGA 1 chr22:28315489-28315509 ( 12) CCCTCGGG 1 chr1:207995676-207995696 ( 6) CCCAGAGT 1 chr6:144673635-144673655 ( 12) CCCACGGG 1 chr14:77371438-77371458 ( 9) CACTGGGG 1 chr1:212360108-212360128 ( 9) CTCTGGAG 1 chr22:39780968-39780988 ( 1) CCTGGGGG 1 chr10:73528731-73528751 ( 13) TCTAGAGA 1 chr6:2733634-2733654 ( 8) CTCAGAAA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCWGGGR MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.93199 E= 1.4e-085 -1329 172 -1329 -210 -431 163 -1329 -110 -73 138 -1329 -72 118 -1329 -257 122 -1329 -385 172 -1329 -41 -1329 151 -1329 -151 -1329 164 -1329 127 -326 63 -284 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCWGGGR MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 100 E= 1.4e-085 0.000000 0.950000 0.000000 0.050000 0.010000 0.890000 0.000000 0.100000 0.120000 0.750000 0.000000 0.130000 0.450000 0.000000 0.050000 0.500000 0.000000 0.020000 0.980000 0.000000 0.150000 0.000000 0.850000 0.000000 0.070000 0.000000 0.930000 0.000000 0.480000 0.030000 0.460000 0.030000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCWGGGR MEME-1 regular expression -------------------------------------------------------------------------------- CCC[TA]GGG[AG] -------------------------------------------------------------------------------- Time 5.29 secs. ******************************************************************************** ******************************************************************************** MOTIF WGGRAAYT MEME-2 width = 8 sites = 15 llr = 120 E-value = 1.9e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif WGGRAAYT MEME-2 Description -------------------------------------------------------------------------------- Simplified A 5:33aa2: pos.-specific C ::::::3: probability G :875:::: matrix T 52:2::5a bits 2.3 ** * 2.1 ** * 1.9 ** * 1.6 ** * Relative 1.4 ** * Entropy 1.2 *** ** * (11.5 bits) 0.9 *** ** * 0.7 *** **** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AGGGAATT consensus TTAA C sequence T A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WGGRAAYT MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:92864818-92864838 3 6.44e-06 TC AGGAAATT CTGGACTCCC chr3:27722911-27722931 2 1.61e-05 C AGGGAATT AAGATGACTT chr21:46524635-46524655 5 1.61e-05 GAGT AGGGAATT TCCCTGGC chr14:93479782-93479802 2 3.34e-05 C TGGGAATT TCTTCCCTCC chr12:86907751-86907771 1 5.11e-05 . agagaatt gtcatcatct chr7:150452741-150452761 2 7.62e-05 C AGGAAAAT AACAATGTGT chr10:45916017-45916037 7 9.38e-05 ACTGGC AGGAAACT GAAACT chr3:10334638-10334658 12 1.44e-04 CCCTGGGAGT TGGAAACT C chr13:61821947-61821967 7 1.44e-04 tccctg tgggaaat gtggat chr5:95157866-95157886 2 1.67e-04 T AGATAATT CCCCAGGGAC chr1:44784105-44784125 8 1.90e-04 GTGGTAT AGGTAAAT CCCAG chr15:33615975-33615995 3 2.67e-04 GG TGGTAACT TTGACTGTCC chr2:38209446-38209466 10 2.85e-04 aactctcac ttaaaatt ccc chr4:104012984-104013004 10 2.94e-04 GGCACAGAT TTAGAATT CTC chr4:159973667-159973687 7 3.63e-04 TTGTGG TTGGAACT TGATTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WGGRAAYT MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:92864818-92864838 6.4e-06 2_[+2]_10 chr3:27722911-27722931 1.6e-05 1_[+2]_11 chr21:46524635-46524655 1.6e-05 4_[+2]_8 chr14:93479782-93479802 3.3e-05 1_[+2]_11 chr12:86907751-86907771 5.1e-05 [+2]_12 chr7:150452741-150452761 7.6e-05 1_[+2]_11 chr10:45916017-45916037 9.4e-05 6_[+2]_6 chr3:10334638-10334658 0.00014 11_[+2]_1 chr13:61821947-61821967 0.00014 6_[+2]_6 chr5:95157866-95157886 0.00017 1_[+2]_11 chr1:44784105-44784125 0.00019 7_[+2]_5 chr15:33615975-33615995 0.00027 2_[+2]_10 chr2:38209446-38209466 0.00028 9_[+2]_3 chr4:104012984-104013004 0.00029 9_[+2]_3 chr4:159973667-159973687 0.00036 6_[+2]_6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WGGRAAYT MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF WGGRAAYT width=8 seqs=15 chr1:92864818-92864838 ( 3) AGGAAATT 1 chr3:27722911-27722931 ( 2) AGGGAATT 1 chr21:46524635-46524655 ( 5) AGGGAATT 1 chr14:93479782-93479802 ( 2) TGGGAATT 1 chr12:86907751-86907771 ( 1) AGAGAATT 1 chr7:150452741-150452761 ( 2) AGGAAAAT 1 chr10:45916017-45916037 ( 7) AGGAAACT 1 chr3:10334638-10334658 ( 12) TGGAAACT 1 chr13:61821947-61821967 ( 7) TGGGAAAT 1 chr5:95157866-95157886 ( 2) AGATAATT 1 chr1:44784105-44784125 ( 8) AGGTAAAT 1 chr15:33615975-33615995 ( 3) TGGTAACT 1 chr2:38209446-38209466 ( 10) TTAAAATT 1 chr4:104012984-104013004 ( 10) TTAGAATT 1 chr4:159973667-159973687 ( 7) TTGGAACT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WGGRAAYT MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.0312 E= 1.9e+002 142 -1055 -1055 112 -1055 -1055 143 -10 42 -1055 130 -1055 74 -1055 65 -10 233 -1055 -1055 -1055 233 -1055 -1055 -1055 1 -11 -1055 131 -1055 -1055 -1055 222 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WGGRAAYT MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 15 E= 1.9e+002 0.533333 0.000000 0.000000 0.466667 0.000000 0.000000 0.800000 0.200000 0.266667 0.000000 0.733333 0.000000 0.333333 0.000000 0.466667 0.200000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.200000 0.266667 0.000000 0.533333 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif WGGRAAYT MEME-2 regular expression -------------------------------------------------------------------------------- [AT][GT][GA][GAT]AA[TCA]T -------------------------------------------------------------------------------- Time 8.22 secs. ******************************************************************************** ******************************************************************************** MOTIF GMATTCCC MEME-3 width = 8 sites = 6 llr = 58 E-value = 2.0e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif GMATTCCC MEME-3 Description -------------------------------------------------------------------------------- Simplified A :5a::::: pos.-specific C :3::2aaa probability G a::::::: matrix T :2:a8::: bits 2.3 ** 2.1 ** 1.9 * ** *** 1.6 * ** *** Relative 1.4 * ****** Entropy 1.2 * ****** (13.8 bits) 0.9 * ****** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel GAATTCCC consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GMATTCCC MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr6:74160991-74161011 11 1.30e-05 CCATACATTT GAATTCCC CC chr12:104914529-10491454 13 1.30e-05 AGGGGCTTTT GAATTCCC chr21:37608837-37608857 13 3.19e-05 GTACATCTGT GCATTCCC chr19:50411442-50411462 1 3.19e-05 . GCATTCCC CTCATGAACT chr11:64442481-64442501 13 4.60e-05 TTCTAGGATG GTATTCCC chr5:68036249-68036269 12 6.34e-05 ccacagaata gaatcccc t -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GMATTCCC MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr6:74160991-74161011 1.3e-05 10_[+3]_2 chr12:104914529-10491454 1.3e-05 12_[+3] chr21:37608837-37608857 3.2e-05 12_[+3] chr19:50411442-50411462 3.2e-05 [+3]_12 chr11:64442481-64442501 4.6e-05 12_[+3] chr5:68036249-68036269 6.3e-05 11_[+3]_1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GMATTCCC MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GMATTCCC width=8 seqs=6 chr6:74160991-74161011 ( 11) GAATTCCC 1 chr12:104914529-10491454 ( 13) GAATTCCC 1 chr21:37608837-37608857 ( 13) GCATTCCC 1 chr19:50411442-50411462 ( 1) GCATTCCC 1 chr11:64442481-64442501 ( 13) GTATTCCC 1 chr5:68036249-68036269 ( 12) GAATCCCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GMATTCCC MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.73685 E= 2.0e+003 -923 -923 175 -923 133 21 -923 -37 233 -923 -923 -923 -923 -923 -923 222 -923 -79 -923 195 -923 179 -923 -923 -923 179 -923 -923 -923 179 -923 -923 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GMATTCCC MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 6 E= 2.0e+003 0.000000 0.000000 1.000000 0.000000 0.500000 0.333333 0.000000 0.166667 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.166667 0.000000 0.833333 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GMATTCCC MEME-3 regular expression -------------------------------------------------------------------------------- G[AC]ATTCCC -------------------------------------------------------------------------------- Time 9.09 secs. ******************************************************************************** ******************************************************************************** MOTIF CAAAACAG MEME-4 width = 8 sites = 2 llr = 24 E-value = 2.0e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif CAAAACAG MEME-4 Description -------------------------------------------------------------------------------- Simplified A :aaaa:a: pos.-specific C a::::a:: probability G :::::::a matrix T :::::::: bits 2.3 **** * 2.1 **** * 1.9 ******** 1.6 ******** Relative 1.4 ******** Entropy 1.2 ******** (17.0 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CAAAACAG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAAAACAG MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr17:18761254-18761274 11 7.71e-06 CCCCAGGGAC CAAAACAG GC chr16:88991825-88991845 9 7.71e-06 TGCTGAGT CAAAACAG CCCC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAAAACAG MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr17:18761254-18761274 7.7e-06 10_[+4]_2 chr16:88991825-88991845 7.7e-06 8_[+4]_4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAAAACAG MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CAAAACAG width=8 seqs=2 chr17:18761254-18761274 ( 11) CAAAACAG 1 chr16:88991825-88991845 ( 9) CAAAACAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAAAACAG MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.6653 E= 2.0e+003 -765 179 -765 -765 232 -765 -765 -765 232 -765 -765 -765 232 -765 -765 -765 232 -765 -765 -765 -765 179 -765 -765 232 -765 -765 -765 -765 -765 174 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAAAACAG MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 2.0e+003 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CAAAACAG MEME-4 regular expression -------------------------------------------------------------------------------- CAAAACAG -------------------------------------------------------------------------------- Time 9.74 secs. ******************************************************************************** ******************************************************************************** MOTIF AAAGGACT MEME-5 width = 8 sites = 4 llr = 42 E-value = 2.9e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAAGGACT MEME-5 Description -------------------------------------------------------------------------------- Simplified A aaa::a:: pos.-specific C ::::::8: probability G :::8a:3: matrix T :::3:::a bits 2.3 *** * * 2.1 *** * * 1.9 *** ** * 1.6 *** ** * Relative 1.4 *** ** * Entropy 1.2 ****** * (15.3 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AAAGGACT consensus T G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGGACT MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr8:70725804-70725824 9 8.62e-06 AAGGAGCA AAAGGACT ACCT chr11:7495156-7495176 10 8.62e-06 GCAATCCCC AAAGGACT CAG chr2:6966775-6966795 8 1.48e-05 agggagg aaatgact cagtt chr2:158301280-158301300 3 2.38e-05 GG AAAGGAGT GGGCAGGAAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGGACT MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr8:70725804-70725824 8.6e-06 8_[+5]_4 chr11:7495156-7495176 8.6e-06 9_[+5]_3 chr2:6966775-6966795 1.5e-05 7_[+5]_5 chr2:158301280-158301300 2.4e-05 2_[+5]_10 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGGACT MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAAGGACT width=8 seqs=4 chr8:70725804-70725824 ( 9) AAAGGACT 1 chr11:7495156-7495176 ( 10) AAAGGACT 1 chr2:6966775-6966795 ( 8) AAATGACT 1 chr2:158301280-158301300 ( 3) AAAGGAGT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGGACT MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.66445 E= 2.9e+003 232 -865 -865 -865 232 -865 -865 -865 232 -865 -865 -865 -865 -865 133 22 -865 -865 175 -865 232 -865 -865 -865 -865 138 -25 -865 -865 -865 -865 222 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGGACT MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 2.9e+003 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.750000 0.250000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.750000 0.250000 0.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGGACT MEME-5 regular expression -------------------------------------------------------------------------------- AAA[GT]GA[CG]T -------------------------------------------------------------------------------- Time 10.38 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr21:39073183-39073203 2.69e-01 20 chr1:233088834-233088854 4.19e-01 20 chr7:151451348-151451368 2.95e-01 20 chr11:5145456-5145476 7.02e-01 20 chr11:69485190-69485210 4.37e-01 20 chr3:184187335-184187355 8.70e-01 20 chr20:39594899-39594919 8.16e-01 20 chr13:36295231-36295251 1.44e-02 2_[+1(9.26e-05)]_10 chr22:29871750-29871770 8.19e-01 20 chr10:6690063-6690083 1.28e-01 20 chr20:7075235-7075255 8.38e-01 20 chr11:65407829-65407849 2.52e-02 20 chr1:212360108-212360128 1.20e-02 20 chr11:20044307-20044327 4.12e-01 20 chr1:224238690-224238710 3.27e-01 20 chr22:39780968-39780988 5.06e-01 20 chr15:101947816-10194783 2.61e-02 20 chr2:204553678-204553698 3.24e-02 20 chr17:9828247-9828267 6.59e-02 20 chr3:48236093-48236113 1.94e-01 20 chr1:44784105-44784125 9.89e-03 20 chr3:69373729-69373749 5.28e-01 20 chr7:148272834-148272854 1.27e-02 20 chr2:7567573-7567593 1.07e-03 20 chr16:84697520-84697540 7.13e-01 20 chr7:139593975-139593995 3.70e-02 20 chr2:6913415-6913435 9.92e-01 20 chr10:92737399-92737419 7.62e-02 20 chr3:149732710-149732730 1.59e-02 20 chr9:140162580-140162600 9.74e-01 20 chr6:97243010-97243030 1.38e-02 20 chr2:75904578-75904598 3.12e-01 20 chr21:32509296-32509316 9.40e-01 20 chr16:18980745-18980765 9.35e-01 20 chr12:110809363-11080938 2.03e-02 7_[+1(5.21e-05)]_5 chr18:46305236-46305256 8.59e-02 3_[+1(9.26e-05)]_9 chr4:1901165-1901185 6.32e-01 20 chr19:42618314-42618334 6.14e-02 7_[+1(9.26e-05)]_5 chr19:50411442-50411462 6.36e-03 [+3(3.19e-05)]_12 chr17:62067963-62067983 5.23e-02 20 chr10:75856717-75856737 3.37e-01 20 chr2:42523533-42523553 4.65e-03 4_[+1(9.26e-05)]_8 chr17:38480370-38480390 1.57e-01 20 chr5:153900689-153900709 7.65e-05 20 chr16:9023384-9023404 8.76e-01 20 chr6:15254436-15254456 3.39e-02 20 chr1:92864818-92864838 2.16e-04 2_[+2(6.44e-06)]_10 chr8:22776139-22776159 5.56e-05 [+3(1.30e-05)]_12 chr11:108525895-10852591 8.70e-02 20 chr21:47674308-47674328 4.13e-03 20 chr16:88991825-88991845 1.81e-03 8_[+4(7.71e-06)]_4 chr12:104914529-10491454 7.85e-04 12_[+3(1.30e-05)] chr15:53027820-53027840 1.84e-01 20 chr2:27631103-27631123 1.82e-04 20 chr4:56275840-56275860 1.25e-02 3_[+1(2.70e-05)]_9 chr2:207019074-207019094 2.02e-01 20 chr22:30787262-30787282 9.82e-01 20 chr14:70060228-70060248 8.84e-01 20 chr17:16884253-16884273 9.39e-02 20 chr4:159973667-159973687 1.62e-01 20 chr18:74695415-74695435 9.29e-01 20 chr12:23358288-23358308 6.05e-01 20 chr22:22146074-22146094 6.59e-05 [+1(5.21e-05)]_12 chr6:144673635-144673655 4.35e-01 20 chr17:70385456-70385476 9.43e-01 20 chr10:71476908-71476928 1.54e-01 20 chr3:184135822-184135842 1.45e-03 6_[+1(2.70e-05)]_6 chr19:8009298-8009318 9.60e-01 20 chr11:65097569-65097589 2.77e-01 20 chr2:65165264-65165284 3.38e-01 20 chr7:27962716-27962736 1.17e-02 [+1(9.26e-05)]_12 chr5:71748179-71748199 7.48e-01 20 chr7:150452741-150452761 1.77e-03 1_[+2(7.62e-05)]_11 chr5:131693805-131693825 4.45e-02 4_[+1(9.26e-05)]_8 chr1:43823886-43823906 8.54e-01 20 chr21:37608837-37608857 1.49e-02 12_[+3(3.19e-05)] chr21:46524635-46524655 2.89e-04 4_[+2(1.61e-05)]_8 chr18:33047791-33047811 1.52e-02 20 chr5:95157866-95157886 2.01e-06 10_[+1(5.21e-05)]_2 chr2:38209446-38209466 1.38e-03 20 chr2:206544891-206544911 3.16e-01 20 chr6:3746665-3746685 2.12e-01 20 chr12:6649517-6649537 8.17e-01 20 chr11:120644459-12064447 9.06e-03 20 chr5:169733523-169733543 3.58e-02 12_[+1(5.21e-05)] chr1:202134032-202134052 6.50e-01 20 chr7:148724215-148724235 2.41e-04 20 chr14:50514258-50514278 9.03e-02 20 chr6:6333401-6333421 8.87e-01 20 chr5:37184992-37185012 1.65e-02 20 chr22:22465541-22465561 1.06e-01 20 chr2:171669396-171669416 8.73e-01 20 chr6:74160991-74161011 3.16e-04 10_[+3(1.30e-05)]_2 chr12:29879074-29879094 2.23e-02 20 chr3:45951205-45951225 3.60e-01 20 chr4:104012984-104013004 2.49e-03 20 chr12:11933595-11933615 2.01e-03 1_[+1(9.26e-05)]_11 chr12:11716957-11716977 1.28e-03 20 chr1:25250202-25250222 9.52e-02 20 chr21:42741511-42741531 4.34e-01 20 chr7:95083947-95083967 2.02e-02 20 chr2:25622583-25622603 6.91e-01 20 chr17:18761254-18761274 3.63e-05 1_[+1(5.21e-05)]_1_[+4(7.71e-06)]_2 chr12:1771197-1771217 6.30e-01 20 chr11:76385770-76385790 2.06e-04 20 chr6:2733634-2733654 6.95e-02 20 chr11:64645052-64645072 3.77e-01 20 chr9:88861880-88861900 4.13e-01 20 chr5:131836978-131836998 9.63e-04 20 chrX:73726518-73726538 3.08e-02 20 chr5:168307092-168307112 9.91e-01 20 chr12:54591576-54591596 5.22e-02 20 chr1:203142884-203142904 9.08e-03 20 chr16:15850158-15850178 1.79e-03 20 chr2:200511324-200511344 5.44e-01 20 chr10:71867303-71867323 1.68e-02 9_[+1(9.26e-05)]_3 chr22:24142676-24142696 9.81e-01 20 chr1:200986625-200986645 1.31e-02 20 chr8:103952709-103952729 8.31e-01 20 chr1:26869804-26869824 9.60e-01 20 chr10:45916017-45916037 2.49e-02 6_[+2(9.38e-05)]_6 chr5:7794560-7794580 3.72e-01 20 chr1:207995676-207995696 2.84e-01 20 chr12:131455335-13145535 9.92e-01 20 chr13:78775726-78775746 8.28e-03 20 chr19:949303-949323 2.19e-01 20 chr13:61821947-61821967 1.14e-02 20 chr1:17421311-17421331 1.27e-01 5_[+1(9.26e-05)]_7 chr10:32043109-32043129 5.32e-02 [+1(9.26e-05)]_12 chr5:152860161-152860181 9.17e-01 20 chr17:16190407-16190427 7.03e-02 5_[+1(9.26e-05)]_7 chr1:211870870-211870890 6.52e-01 20 chr15:70796706-70796726 6.79e-01 20 chr17:53514896-53514916 1.02e-02 2_[+1(2.70e-05)]_10 chr12:57856626-57856646 2.36e-01 20 chr14:77371438-77371458 5.65e-02 20 chr4:38762716-38762736 9.08e-01 20 chr21:30638614-30638634 1.31e-03 20 chr22:28315489-28315509 3.98e-01 20 chr19:51208923-51208943 6.05e-02 20 chr16:56922916-56922936 7.44e-03 20 chr16:75186725-75186745 1.95e-02 20 chr19:2332554-2332574 4.86e-01 20 chr17:7994521-7994541 2.79e-02 20 chr14:75689017-75689037 1.52e-01 20 chr1:118077681-118077701 1.94e-02 20 chr19:45274066-45274086 6.45e-03 20 chr2:62369375-62369395 2.35e-02 8_[+1(9.26e-05)]_4 chr6:44706442-44706462 3.49e-01 20 chr21:37885921-37885941 5.41e-03 20 chr5:68036249-68036269 1.01e-04 11_[+3(6.34e-05)]_1 chr21:43804463-43804483 6.08e-02 20 chr4:7256613-7256633 6.69e-01 20 chr3:52057996-52058016 2.66e-02 6_[+1(5.21e-05)]_6 chr15:44838762-44838782 8.62e-01 20 chr19:7410892-7410912 1.67e-02 3_[+1(5.21e-05)]_9 chr5:149036353-149036373 4.83e-01 20 chr13:33365940-33365960 5.87e-02 20 chrX:40399192-40399212 2.65e-02 20 chr14:52294850-52294870 7.35e-03 20 chr21:34753034-34753054 3.72e-02 20 chr2:96822931-96822951 2.03e-03 20 chr1:32803123-32803143 4.79e-02 20 chr10:82349782-82349802 2.64e-01 20 chr8:141709574-141709594 8.87e-05 20 chr8:61681166-61681186 8.19e-01 20 chr16:89041274-89041294 4.23e-02 2_[+1(9.26e-05)]_10 chr3:171515313-171515333 5.71e-01 20 chr12:133532415-13353243 9.49e-01 20 chr1:109655467-109655487 7.71e-01 20 chr16:11403823-11403843 9.32e-01 20 chr11:133415155-13341517 1.92e-02 20 chr12:131724475-13172449 5.56e-01 20 chr22:22110357-22110377 2.86e-01 20 chr5:131721205-131721225 9.31e-01 20 chr14:71130546-71130566 7.95e-02 20 chr14:51670109-51670129 9.76e-01 20 chr19:4375829-4375849 2.28e-01 20 chr14:105491319-10549133 7.08e-01 20 chr9:33202709-33202729 2.94e-01 20 chr8:28911820-28911840 2.23e-03 20 chr9:102272288-102272308 5.28e-01 20 chr8:52308915-52308935 1.89e-03 20 chr14:65787758-65787778 1.15e-03 9_[+1(9.26e-05)]_3 chr22:40295243-40295263 7.99e-02 12_[+1(9.26e-05)] chr7:156333519-156333539 5.88e-02 20 chr19:7884409-7884429 1.59e-04 20 chr2:158301280-158301300 8.83e-03 2_[+5(2.38e-05)]_10 chr14:70706696-70706716 1.38e-02 20 chr20:11242435-11242455 6.92e-01 20 chr10:82359243-82359263 9.45e-02 2_[+1(9.26e-05)]_10 chr3:9732939-9732959 9.85e-01 20 chr1:8703811-8703831 9.80e-01 20 chr11:36377949-36377969 7.64e-04 20 chr6:36721067-36721087 8.97e-01 20 chr12:10875307-10875327 1.16e-02 11_[+1(9.26e-05)]_1 chr9:92450442-92450462 4.17e-02 20 chr11:64442481-64442501 3.48e-03 12_[+3(4.60e-05)] chr18:35110009-35110029 4.48e-02 20 chr11:45392937-45392957 9.63e-01 20 chr2:74212785-74212805 5.98e-01 20 chr15:33615975-33615995 8.27e-02 20 chr11:46324659-46324679 2.01e-01 20 chr6:7239255-7239275 2.18e-03 8_[+1(2.70e-05)]_4 chr1:28503857-28503877 1.05e-02 20 chr3:10334638-10334658 3.10e-04 1_[+1(2.70e-05)]_11 chr3:27722911-27722931 3.09e-04 1_[+2(1.61e-05)]_11 chr1:2487461-2487481 8.13e-01 20 chr12:86907751-86907771 1.84e-03 [+2(5.11e-05)]_12 chr10:1704221-1704241 1.39e-03 10_[+1(5.21e-05)]_2 chr22:36146001-36146021 6.03e-01 20 chr19:36050375-36050395 9.30e-01 20 chr3:49843065-49843085 5.25e-02 20 chr19:6088030-6088050 1.84e-01 20 chr9:131406160-131406180 1.34e-01 20 chr5:168843970-168843990 3.73e-01 20 chr2:6966775-6966795 4.05e-04 7_[+5(1.48e-05)]_5 chr10:1020243-1020263 4.32e-03 20 chr20:34205685-34205705 1.99e-02 10_[+1(5.21e-05)]_2 chr1:52498534-52498554 3.62e-01 20 chr1:31223821-31223841 2.66e-02 10_[+1(2.70e-05)]_2 chr12:12164996-12165016 2.86e-01 20 chr16:15859958-15859978 2.83e-01 20 chr9:136811164-136811184 1.62e-02 20 chr1:66868086-66868106 7.92e-03 4_[+1(5.21e-05)]_8 chr6:36749662-36749682 1.72e-02 20 chr10:60756804-60756824 6.08e-02 20 chr15:73928934-73928954 7.45e-01 20 chr2:220024990-220025010 5.46e-01 20 chr5:180402474-180402494 6.43e-02 20 chrX:19881814-19881834 4.52e-01 20 chrX:78515101-78515121 9.88e-03 7_[+1(9.26e-05)]_5 chr14:100403691-10040371 8.75e-02 20 chr10:73528731-73528751 6.75e-02 20 chr9:35619966-35619986 3.04e-01 20 chr15:101696938-10169695 1.20e-03 [+1(2.70e-05)]_12 chr1:222014006-222014026 7.39e-02 20 chr6:89203671-89203691 1.79e-02 20 chr2:85097644-85097664 8.31e-01 20 chr7:114571953-114571973 1.35e-01 20 chr13:31018190-31018210 9.52e-01 20 chr4:2939177-2939197 1.50e-01 20 chr11:7495156-7495176 2.97e-05 9_[+5(8.62e-06)]_3 chr9:124260542-124260562 3.03e-01 20 chr18:46250406-46250426 3.15e-01 20 chr9:85911209-85911229 1.02e-01 20 chr3:32478521-32478541 7.79e-01 20 chr1:245103691-245103711 7.95e-01 20 chr14:93479782-93479802 5.82e-03 1_[+2(3.34e-05)]_11 chr8:70725804-70725824 4.95e-04 8_[+5(8.62e-06)]_4 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n10.farnam.hpc.yale.internal ********************************************************************************