******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/E2F4.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr4:175850698-175850718 1.0000 20 chr20:3776882-3776902 1.0000 20 chrX:53448903-53448923 1.0000 20 chr10:70811279-70811299 1.0000 20 chr6:111135774-111135794 1.0000 20 chr12:99038758-99038778 1.0000 20 chr10:70231524-70231544 1.0000 20 chr19:44259782-44259802 1.0000 20 chr2:200775880-200775900 1.0000 20 chr19:55852813-55852833 1.0000 20 chr19:47634506-47634526 1.0000 20 chr12:69140624-69140644 1.0000 20 chr6:27807693-27807713 1.0000 20 chrX:14891180-14891200 1.0000 20 chr19:30302873-30302893 1.0000 20 chrX:100353153-100353173 1.0000 20 chr2:209176807-209176827 1.0000 20 chr18:51884277-51884297 1.0000 20 chr12:56110276-56110296 1.0000 20 chr4:184425789-184425809 1.0000 20 chr17:71187800-71187820 1.0000 20 chr8:95487328-95487348 1.0000 20 chr11:6627493-6627513 1.0000 20 chrX:133931372-133931392 1.0000 20 chr4:1873011-1873031 1.0000 20 chr6:106958663-106958683 1.0000 20 chr3:186857245-186857265 1.0000 20 chr17:26926038-26926058 1.0000 20 chr6:167412551-167412571 1.0000 20 chr10:124639236-12463925 1.0000 20 chr1:155246988-155247008 1.0000 20 chr20:42295721-42295741 1.0000 20 chr18:47901424-47901444 1.0000 20 chr6:26218009-26218029 1.0000 20 chr4:154265801-154265821 1.0000 20 chr8:67525492-67525512 1.0000 20 chr1:207818399-207818419 1.0000 20 chr8:27695331-27695351 1.0000 20 chr3:160167766-160167786 1.0000 20 chr21:33651350-33651370 1.0000 20 chr6:165033920-165033940 1.0000 20 chr5:141704708-141704728 1.0000 20 chr2:97001532-97001552 1.0000 20 chr12:2986332-2986352 1.0000 20 chr10:64028437-64028457 1.0000 20 chr10:129924725-12992474 1.0000 20 chr6:83775642-83775662 1.0000 20 chrX:150151636-150151656 1.0000 20 chr16:23690131-23690151 1.0000 20 chrX:69509929-69509949 1.0000 20 chr6:27862299-27862319 1.0000 20 chr8:101158032-101158052 1.0000 20 chr16:67281550-67281570 1.0000 20 chr20:60697408-60697428 1.0000 20 chr16:4635653-4635673 1.0000 20 chr17:34257790-34257810 1.0000 20 chr5:159848823-159848843 1.0000 20 chr10:60027939-60027959 1.0000 20 chr2:69664147-69664167 1.0000 20 chr13:45683006-45683026 1.0000 20 chr9:35665205-35665225 1.0000 20 chr19:40728079-40728099 1.0000 20 chr11:134093882-13409390 1.0000 20 chr11:74204143-74204163 1.0000 20 chr5:72144831-72144851 1.0000 20 chr12:105724319-10572433 1.0000 20 chr9:36572849-36572869 1.0000 20 chr5:149737663-149737683 1.0000 20 chr4:178230999-178231019 1.0000 20 chr5:138729063-138729083 1.0000 20 chr2:242626271-242626291 1.0000 20 chr16:31044163-31044183 1.0000 20 chr15:68346438-68346458 1.0000 20 chr7:36429431-36429451 1.0000 20 chrX:71458867-71458887 1.0000 20 chr1:68962786-68962806 1.0000 20 chr1:156542338-156542358 1.0000 20 chr8:124084907-124084927 1.0000 20 chr1:12123306-12123326 1.0000 20 chr16:433526-433546 1.0000 20 chr19:49631521-49631541 1.0000 20 chr11:13485247-13485267 1.0000 20 chr11:58912237-58912257 1.0000 20 chr5:59995973-59995993 1.0000 20 chr10:18949027-18949047 1.0000 20 chr19:53971329-53971349 1.0000 20 chr16:2510080-2510100 1.0000 20 chr9:21802528-21802548 1.0000 20 chr17:29158961-29158981 1.0000 20 chr20:44061137-44061157 1.0000 20 chr4:81136750-81136770 1.0000 20 chr10:123733957-12373397 1.0000 20 chr19:53073867-53073887 1.0000 20 chr3:88198761-88198781 1.0000 20 chr12:9800616-9800636 1.0000 20 chr7:45039398-45039418 1.0000 20 chr15:45695669-45695689 1.0000 20 chr6:126661263-126661283 1.0000 20 chr8:117886482-117886502 1.0000 20 chr19:16222173-16222193 1.0000 20 chr10:5454496-5454516 1.0000 20 chr1:28845116-28845136 1.0000 20 chr16:3019250-3019270 1.0000 20 chr2:220083832-220083852 1.0000 20 chr5:612485-612505 1.0000 20 chr10:27444266-27444286 1.0000 20 chr1:45205479-45205499 1.0000 20 chr18:2571548-2571568 1.0000 20 chr6:14254958-14254978 1.0000 20 chr2:27579109-27579129 1.0000 20 chr16:67596271-67596291 1.0000 20 chr6:100062739-100062759 1.0000 20 chr9:77567897-77567917 1.0000 20 chr2:9614137-9614157 1.0000 20 chr19:37095662-37095682 1.0000 20 chr19:6199543-6199563 1.0000 20 chr12:6960471-6960491 1.0000 20 chr2:26569684-26569704 1.0000 20 chr4:1723216-1723236 1.0000 20 chr1:23857777-23857797 1.0000 20 chr2:17935392-17935412 1.0000 20 chr2:203736496-203736516 1.0000 20 chr19:53426324-53426344 1.0000 20 chr10:124907514-12490753 1.0000 20 chr8:73920905-73920925 1.0000 20 chr12:122110590-12211061 1.0000 20 chr16:46723558-46723578 1.0000 20 chr6:80714353-80714373 1.0000 20 chr16:20817819-20817839 1.0000 20 chr20:35402215-35402235 1.0000 20 chr8:120868151-120868171 1.0000 20 chr17:79369041-79369061 1.0000 20 chr18:56338487-56338507 1.0000 20 chr22:36728967-36728987 1.0000 20 chr4:2243848-2243868 1.0000 20 chr6:24775581-24775601 1.0000 20 chr1:109419563-109419583 1.0000 20 chr1:176176446-176176466 1.0000 20 chr19:14247428-14247448 1.0000 20 chr19:54024324-54024344 1.0000 20 chr19:4909985-4910005 1.0000 20 chr1:160255024-160255044 1.0000 20 chr17:38703781-38703801 1.0000 20 chr22:39378394-39378414 1.0000 20 chr8:121881191-121881211 1.0000 20 chr1:226496871-226496891 1.0000 20 chr13:53029564-53029584 1.0000 20 chr10:58121061-58121081 1.0000 20 chr17:30186444-30186464 1.0000 20 chr14:54863552-54863572 1.0000 20 chr2:234763206-234763226 1.0000 20 chr16:838646-838666 1.0000 20 chr10:95256335-95256355 1.0000 20 chr2:71503661-71503681 1.0000 20 chr2:25016316-25016336 1.0000 20 chr3:52188447-52188467 1.0000 20 chr6:27099772-27099792 1.0000 20 chr5:162887600-162887620 1.0000 20 chr6:86388725-86388745 1.0000 20 chr17:37558917-37558937 1.0000 20 chrX:118816798-118816818 1.0000 20 chr2:136874575-136874595 1.0000 20 chr17:73268030-73268050 1.0000 20 chr1:93646257-93646277 1.0000 20 chr1:200589890-200589910 1.0000 20 chr11:27384749-27384769 1.0000 20 chr17:6347734-6347754 1.0000 20 chr16:85722570-85722590 1.0000 20 chr17:80674627-80674647 1.0000 20 chr7:158497458-158497478 1.0000 20 chr1:236768158-236768178 1.0000 20 chr1:26232069-26232089 1.0000 20 chr19:49224034-49224054 1.0000 20 chr8:28645498-28645518 1.0000 20 chr12:98910391-98910411 1.0000 20 chr4:15683212-15683232 1.0000 20 chr7:64734278-64734298 1.0000 20 chr19:47359439-47359459 1.0000 20 chrX:48555147-48555167 1.0000 20 chr17:8113922-8113942 1.0000 20 chr4:6675686-6675706 1.0000 20 chr2:10262783-10262803 1.0000 20 chr17:27760647-27760667 1.0000 20 chr17:37213244-37213264 1.0000 20 chr11:10562346-10562366 1.0000 20 chr1:156265496-156265516 1.0000 20 chr1:36235580-36235600 1.0000 20 chr4:185654582-185654602 1.0000 20 chr4:129733265-129733285 1.0000 20 chr1:197115825-197115845 1.0000 20 chr20:23347175-23347195 1.0000 20 chr9:98273789-98273809 1.0000 20 chr5:169010738-169010758 1.0000 20 chr21:32931503-32931523 1.0000 20 chr2:136776969-136776989 1.0000 20 chr5:112312256-112312276 1.0000 20 chr19:4535383-4535403 1.0000 20 chr6:166796594-166796614 1.0000 20 chr1:146967004-146967024 1.0000 20 chr17:42219286-42219306 1.0000 20 chr2:46095169-46095189 1.0000 20 chr6:26251126-26251146 1.0000 20 chr19:36391463-36391483 1.0000 20 chr5:36242424-36242444 1.0000 20 chr12:12849131-12849151 1.0000 20 chr19:11750585-11750605 1.0000 20 chr8:26435315-26435335 1.0000 20 chr6:90539490-90539510 1.0000 20 chr8:117887041-117887061 1.0000 20 chr17:33700721-33700741 1.0000 20 chr20:61427683-61427703 1.0000 20 chr11:95523101-95523121 1.0000 20 chr19:50169200-50169220 1.0000 20 chr19:53869281-53869301 1.0000 20 chr12:49524630-49524650 1.0000 20 chr2:215674009-215674029 1.0000 20 chr5:137667536-137667556 1.0000 20 chr11:9595134-9595154 1.0000 20 chr10:105128410-10512843 1.0000 20 chr19:11492058-11492078 1.0000 20 chr10:102820504-10282052 1.0000 20 chr20:25388325-25388345 1.0000 20 chr1:46049145-46049165 1.0000 20 chr2:219773842-219773862 1.0000 20 chr16:89883083-89883103 1.0000 20 chr11:31832775-31832795 1.0000 20 chr21:38630662-38630682 1.0000 20 chr15:91498526-91498546 1.0000 20 chr17:33775873-33775893 1.0000 20 chr17:42263820-42263840 1.0000 20 chr7:99680324-99680344 1.0000 20 chr16:30645767-30645787 1.0000 20 chr1:46050425-46050445 1.0000 20 chr10:121355353-12135537 1.0000 20 chr2:231068216-231068236 1.0000 20 chr4:120987948-120987968 1.0000 20 chr16:28891326-28891346 1.0000 20 chr14:105487520-10548754 1.0000 20 chr12:120315114-12031513 1.0000 20 chr15:90118664-90118684 1.0000 20 chr19:50887590-50887610 1.0000 20 chr12:77459385-77459405 1.0000 20 chr17:1531838-1531858 1.0000 20 chr5:158385495-158385515 1.0000 20 chr19:984857-984877 1.0000 20 chr19:44079760-44079780 1.0000 20 chr19:17392654-17392674 1.0000 20 chr15:64673699-64673719 1.0000 20 chr21:47744354-47744374 1.0000 20 chr8:145743227-145743247 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_E2F4/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/E2F4.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.196 C 0.299 G 0.307 T 0.198 Background letter frequencies (from file dataset with add-one prior applied): A 0.196 C 0.299 G 0.307 T 0.198 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF DTTTSAAA MEME-1 width = 8 sites = 65 llr = 472 E-value = 3.0e-054 ******************************************************************************** -------------------------------------------------------------------------------- Motif DTTTSAAA MEME-1 Description -------------------------------------------------------------------------------- Simplified A 32::1aa7 pos.-specific C 11::5::1 probability G 4:::4::1 matrix T 269a:::1 bits 2.4 * 2.1 * ** 1.9 ** ** 1.6 ** ** Relative 1.4 ** ** Entropy 1.2 ** ** (10.5 bits) 0.9 *** *** 0.7 *** *** 0.5 *** *** 0.2 ******* 0.0 -------- Multilevel GTTTCAAA consensus AA G sequence T -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif DTTTSAAA MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr18:2571548-2571568 3 3.43e-06 GA ATTTCAAA TTCGAACGGC chr12:98910391-98910411 9 1.23e-05 TAACCAAA ATTTGAAA TGAG chr17:6347734-6347754 7 1.23e-05 CGCAGA GTTTCAAA TCGGCT chrX:118816798-118816818 1 1.23e-05 . GTTTCAAA CCAGGGTGGC chr6:14254958-14254978 1 1.23e-05 . atttgaaa agggtttgag chr11:9595134-9595154 12 1.58e-05 CCTCCTTTTT TTTTCAAA C chr17:8113922-8113942 3 1.58e-05 AC TTTTCAAA TCTCCCGCCC chr19:53073867-53073887 1 1.58e-05 . TTTTCAAA GTCCTCACCC chr4:1723216-1723236 3 2.13e-05 GC GTTTGAAA CTCCGGCGCG chr18:51884277-51884297 13 2.13e-05 TGTTGGGGCG GTTTGAAA chr6:27807693-27807713 9 2.13e-05 CGAGGGCA GTTTGAAA CTTG chr10:124907514-12490753 13 2.48e-05 GGCCGGAGCG TTTTGAAA chr16:67596271-67596291 11 2.48e-05 TCGCGCCCGC TTTTGAAA GT chr6:86388725-86388745 11 2.82e-05 GTGGCGCCAG AATTCAAA CA chr6:80714353-80714373 9 2.82e-05 GACGGGGA AATTCAAA CGTG chr7:36429431-36429451 12 2.82e-05 TCGGCGCTGA AATTCAAA T chrX:53448903-53448923 11 2.82e-05 CTGGGTCTGA AATTCAAA AG chr14:54863552-54863572 1 3.34e-05 . CTTTCAAA GGTCTTCTAG chr8:28645498-28645518 8 4.45e-05 GAAGTTT ATTTAAAA ATTTC chr1:28845116-28845136 2 4.45e-05 A GATTCAAA CTGCGCGAgc chr11:58912237-58912257 4 4.45e-05 GGC GATTCAAA CCCCTAGCC chr11:74204143-74204163 9 4.45e-05 GTAGCTGT GATTCAAA ACCC chr9:35665205-35665225 5 4.45e-05 GGCA GATTCAAA TCCCAACC chr10:129924725-12992474 2 4.45e-05 A GATTCAAA TTCTGGCGCT chr2:97001532-97001552 3 4.45e-05 CG ATTTAAAA CCAGCTCAGG chr11:10562346-10562366 9 5.33e-05 GGCGGCAA TATTCAAA CAAC chr17:34257790-34257810 13 6.80e-05 GCCCGCGCTT TTTTAAAA chr5:162887600-162887620 9 8.05e-05 GTGGGGAG ATTTGAAT TTGA chr4:178230999-178231019 4 8.05e-05 GAG ATTTGAAT TTCCTCTGC chr1:109419563-109419583 9 8.95e-05 CGTTGTCG GTTTGAAT GAGA chr5:59995973-59995993 12 8.95e-05 AGGAGCAGCA GTTTGAAT C chr1:156542338-156542358 1 8.95e-05 . GTTTGAAT CTCCCGCCGT chr8:121881191-121881211 8 9.83e-05 tttgccc cattcaaa cactc chr1:12123306-12123326 12 9.83e-05 CGGGGCGGGC CATTCAAA C chr19:53426324-53426344 7 1.17e-04 TGAGGA CTTTAAAA AGCGCG chr19:36391463-36391483 4 1.47e-04 GAG TTTTTAAA CTAGGGGTT chr6:167412551-167412571 9 1.47e-04 GCTCGCCG GCTTCAAA GCTC chr8:101158032-101158052 10 2.18e-04 CCTCCTTAG GTTTGAAC GGC chr6:106958663-106958683 10 2.18e-04 CACTCGGGT GTTTGAAC GCT chr1:46049145-46049165 12 2.33e-04 AAGCCCCGAG CTTTGAAT C chr11:27384749-27384769 4 2.61e-04 CCA AGTTCAAA CTGGCGGAG chr18:56338487-56338507 13 2.97e-04 GGAGGGCTGG GTTTGAAG chr2:25016316-25016336 13 3.20e-04 GTTGGTTTGG TTTTGAAG chr15:91498526-91498546 8 3.50e-04 CGCGCGC CCTTCAAA CCTTT chr19:11750585-11750605 2 3.50e-04 A GGTTGAAA AAGCCCGCGG chr10:60027939-60027959 2 3.50e-04 C ATTTCGAA GTCACGCGTG chr3:186857245-186857265 6 3.50e-04 GCAGC AATTCAAC CGCCGCG chr17:71187800-71187820 7 3.83e-04 GAAATT ATGTGAAA ACGTAg chr11:95523101-95523121 9 4.65e-04 GAAATCCG CTTTGAAC CTGC chr1:26232069-26232089 8 4.65e-04 CCGCGCC TTTTCGAA TCTCC chr5:159848823-159848843 9 5.12e-04 GAGTTGTG GTTTAAAC CAGG chr1:156265496-156265516 5 5.48e-04 ATCC CTTTCAAG GGCGGAGC chr12:77459385-77459405 1 5.87e-04 . ATTTGAGA ATCCACCAAT chr17:79369041-79369061 6 7.09e-04 GCCGG GCTTGAAT TAGGCGC chr6:100062739-100062759 12 7.09e-04 CCGTTTTTGT TTTTGAGA G chr21:47744354-47744374 12 7.38e-04 GCCGCCGCCA TCTTGAAT C chr15:68346438-68346458 6 7.38e-04 AGTAA CTGTCAAA CCTCGCC chr1:207818399-207818419 11 7.38e-04 CTAAGACTCA ATTTCACA CT chr2:209176807-209176827 12 7.38e-04 CCCAAAGCTT TCTTGAAT T chr21:38630662-38630682 7 7.92e-04 tttcag tgttaaaa cctggc chr22:39378394-39378414 1 7.92e-04 . AAGTGAAA CCACAGAGCT chr6:165033920-165033940 11 7.92e-04 CATTAACAAt gtctcaaa gg chr6:126661263-126661283 13 8.59e-04 GTTGGCGGCG GATTCGAA chr20:42295721-42295741 12 1.08e-03 ATAGAAAAGT GCTTCAAC C chr1:45205479-45205499 2 1.27e-03 C GTTTTAAG GACGCTTGCG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif DTTTSAAA MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr18:2571548-2571568 3.4e-06 2_[+1]_10 chr12:98910391-98910411 1.2e-05 8_[+1]_4 chr17:6347734-6347754 1.2e-05 6_[+1]_6 chrX:118816798-118816818 1.2e-05 [+1]_12 chr6:14254958-14254978 1.2e-05 [+1]_12 chr11:9595134-9595154 1.6e-05 11_[+1]_1 chr17:8113922-8113942 1.6e-05 2_[+1]_10 chr19:53073867-53073887 1.6e-05 [+1]_12 chr4:1723216-1723236 2.1e-05 2_[+1]_10 chr18:51884277-51884297 2.1e-05 12_[+1] chr6:27807693-27807713 2.1e-05 8_[+1]_4 chr10:124907514-12490753 2.5e-05 12_[+1] chr16:67596271-67596291 2.5e-05 10_[+1]_2 chr6:86388725-86388745 2.8e-05 10_[+1]_2 chr6:80714353-80714373 2.8e-05 8_[+1]_4 chr7:36429431-36429451 2.8e-05 11_[+1]_1 chrX:53448903-53448923 2.8e-05 10_[+1]_2 chr14:54863552-54863572 3.3e-05 [+1]_12 chr8:28645498-28645518 4.4e-05 7_[+1]_5 chr1:28845116-28845136 4.4e-05 1_[+1]_11 chr11:58912237-58912257 4.4e-05 3_[+1]_9 chr11:74204143-74204163 4.4e-05 8_[+1]_4 chr9:35665205-35665225 4.4e-05 4_[+1]_8 chr10:129924725-12992474 4.4e-05 1_[+1]_11 chr2:97001532-97001552 4.4e-05 2_[+1]_10 chr11:10562346-10562366 5.3e-05 8_[+1]_4 chr17:34257790-34257810 6.8e-05 12_[+1] chr5:162887600-162887620 8e-05 8_[+1]_4 chr4:178230999-178231019 8e-05 3_[+1]_9 chr1:109419563-109419583 9e-05 8_[+1]_4 chr5:59995973-59995993 9e-05 11_[+1]_1 chr1:156542338-156542358 9e-05 [+1]_12 chr8:121881191-121881211 9.8e-05 7_[+1]_5 chr1:12123306-12123326 9.8e-05 11_[+1]_1 chr19:53426324-53426344 0.00012 6_[+1]_6 chr19:36391463-36391483 0.00015 3_[+1]_9 chr6:167412551-167412571 0.00015 8_[+1]_4 chr8:101158032-101158052 0.00022 9_[+1]_3 chr6:106958663-106958683 0.00022 9_[+1]_3 chr1:46049145-46049165 0.00023 11_[+1]_1 chr11:27384749-27384769 0.00026 3_[+1]_9 chr18:56338487-56338507 0.0003 12_[+1] chr2:25016316-25016336 0.00032 12_[+1] chr15:91498526-91498546 0.00035 7_[+1]_5 chr19:11750585-11750605 0.00035 1_[+1]_11 chr10:60027939-60027959 0.00035 1_[+1]_11 chr3:186857245-186857265 0.00035 5_[+1]_7 chr17:71187800-71187820 0.00038 6_[+1]_6 chr11:95523101-95523121 0.00047 8_[+1]_4 chr1:26232069-26232089 0.00047 7_[+1]_5 chr5:159848823-159848843 0.00051 8_[+1]_4 chr1:156265496-156265516 0.00055 4_[+1]_8 chr12:77459385-77459405 0.00059 [+1]_12 chr17:79369041-79369061 0.00071 5_[+1]_7 chr6:100062739-100062759 0.00071 11_[+1]_1 chr21:47744354-47744374 0.00074 11_[+1]_1 chr15:68346438-68346458 0.00074 5_[+1]_7 chr1:207818399-207818419 0.00074 10_[+1]_2 chr2:209176807-209176827 0.00074 11_[+1]_1 chr21:38630662-38630682 0.00079 6_[+1]_6 chr22:39378394-39378414 0.00079 [+1]_12 chr6:165033920-165033940 0.00079 10_[+1]_2 chr6:126661263-126661283 0.00086 12_[+1] chr20:42295721-42295741 0.0011 11_[+1]_1 chr1:45205479-45205499 0.0013 1_[+1]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif DTTTSAAA MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF DTTTSAAA width=8 seqs=65 chr18:2571548-2571568 ( 3) ATTTCAAA 1 chr12:98910391-98910411 ( 9) ATTTGAAA 1 chr17:6347734-6347754 ( 7) GTTTCAAA 1 chrX:118816798-118816818 ( 1) GTTTCAAA 1 chr6:14254958-14254978 ( 1) ATTTGAAA 1 chr11:9595134-9595154 ( 12) TTTTCAAA 1 chr17:8113922-8113942 ( 3) TTTTCAAA 1 chr19:53073867-53073887 ( 1) TTTTCAAA 1 chr4:1723216-1723236 ( 3) GTTTGAAA 1 chr18:51884277-51884297 ( 13) GTTTGAAA 1 chr6:27807693-27807713 ( 9) GTTTGAAA 1 chr10:124907514-12490753 ( 13) TTTTGAAA 1 chr16:67596271-67596291 ( 11) TTTTGAAA 1 chr6:86388725-86388745 ( 11) AATTCAAA 1 chr6:80714353-80714373 ( 9) AATTCAAA 1 chr7:36429431-36429451 ( 12) AATTCAAA 1 chrX:53448903-53448923 ( 11) AATTCAAA 1 chr14:54863552-54863572 ( 1) CTTTCAAA 1 chr8:28645498-28645518 ( 8) ATTTAAAA 1 chr1:28845116-28845136 ( 2) GATTCAAA 1 chr11:58912237-58912257 ( 4) GATTCAAA 1 chr11:74204143-74204163 ( 9) GATTCAAA 1 chr9:35665205-35665225 ( 5) GATTCAAA 1 chr10:129924725-12992474 ( 2) GATTCAAA 1 chr2:97001532-97001552 ( 3) ATTTAAAA 1 chr11:10562346-10562366 ( 9) TATTCAAA 1 chr17:34257790-34257810 ( 13) TTTTAAAA 1 chr5:162887600-162887620 ( 9) ATTTGAAT 1 chr4:178230999-178231019 ( 4) ATTTGAAT 1 chr1:109419563-109419583 ( 9) GTTTGAAT 1 chr5:59995973-59995993 ( 12) GTTTGAAT 1 chr1:156542338-156542358 ( 1) GTTTGAAT 1 chr8:121881191-121881211 ( 8) CATTCAAA 1 chr1:12123306-12123326 ( 12) CATTCAAA 1 chr19:53426324-53426344 ( 7) CTTTAAAA 1 chr19:36391463-36391483 ( 4) TTTTTAAA 1 chr6:167412551-167412571 ( 9) GCTTCAAA 1 chr8:101158032-101158052 ( 10) GTTTGAAC 1 chr6:106958663-106958683 ( 10) GTTTGAAC 1 chr1:46049145-46049165 ( 12) CTTTGAAT 1 chr11:27384749-27384769 ( 4) AGTTCAAA 1 chr18:56338487-56338507 ( 13) GTTTGAAG 1 chr2:25016316-25016336 ( 13) TTTTGAAG 1 chr15:91498526-91498546 ( 8) CCTTCAAA 1 chr19:11750585-11750605 ( 2) GGTTGAAA 1 chr10:60027939-60027959 ( 2) ATTTCGAA 1 chr3:186857245-186857265 ( 6) AATTCAAC 1 chr17:71187800-71187820 ( 7) ATGTGAAA 1 chr11:95523101-95523121 ( 9) CTTTGAAC 1 chr1:26232069-26232089 ( 8) TTTTCGAA 1 chr5:159848823-159848843 ( 9) GTTTAAAC 1 chr1:156265496-156265516 ( 5) CTTTCAAG 1 chr12:77459385-77459405 ( 1) ATTTGAGA 1 chr17:79369041-79369061 ( 6) GCTTGAAT 1 chr6:100062739-100062759 ( 12) TTTTGAGA 1 chr21:47744354-47744374 ( 12) TCTTGAAT 1 chr15:68346438-68346458 ( 6) CTGTCAAA 1 chr1:207818399-207818419 ( 11) ATTTCACA 1 chr2:209176807-209176827 ( 12) TCTTGAAT 1 chr21:38630662-38630682 ( 7) TGTTAAAA 1 chr22:39378394-39378414 ( 1) AAGTGAAA 1 chr6:165033920-165033940 ( 11) GTCTCAAA 1 chr6:126661263-126661283 ( 13) GATTCGAA 1 chr20:42295721-42295741 ( 12) GCTTCAAC 1 chr1:45205479-45205499 ( 2) GTTTTAAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif DTTTSAAA MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.79183 E= 3.0e-054 50 -111 27 12 24 -169 -273 167 -1267 -427 -273 224 -1267 -1267 -1267 233 -108 68 38 -269 228 -1267 -273 -1267 228 -427 -332 -1267 185 -169 -232 -52 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif DTTTSAAA MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 65 E= 3.0e-054 0.276923 0.138462 0.369231 0.215385 0.230769 0.092308 0.046154 0.630769 0.000000 0.015385 0.046154 0.938462 0.000000 0.000000 0.000000 1.000000 0.092308 0.476923 0.400000 0.030769 0.953846 0.000000 0.046154 0.000000 0.953846 0.015385 0.030769 0.000000 0.707692 0.092308 0.061538 0.138462 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif DTTTSAAA MEME-1 regular expression -------------------------------------------------------------------------------- [GAT][TA]TT[CG]AAA -------------------------------------------------------------------------------- Time 3.12 secs. ******************************************************************************** ******************************************************************************** MOTIF KGGGCGGG MEME-2 width = 8 sites = 18 llr = 137 E-value = 2.8e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif KGGGCGGG MEME-2 Description -------------------------------------------------------------------------------- Simplified A 22:::::2 pos.-specific C ::::a::: probability G 48aa:a98 matrix T 4:::::1: bits 2.4 2.1 1.9 1.6 **** Relative 1.4 **** Entropy 1.2 ******* (11.0 bits) 0.9 ******* 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TGGGCGGG consensus G A sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGGG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr17:33700721-33700741 5 4.96e-05 CCAA TGGGCGGG TCTGCTAA chr2:71503661-71503681 11 4.96e-05 GCCTCGGGGG TGGGCGGG TC chr14:105487520-10548754 6 1.26e-04 GGCCG GGGGCGGG GCCTCTT chr2:219773842-219773862 3 1.26e-04 GA GGGGCGGG CCTAAGGGGG chr1:12123306-12123326 3 1.26e-04 CC GGGGCGGG CCATTCAAAC chr6:83775642-83775662 12 1.26e-04 CCCGGAGGCC GGGGCGGG G chr13:53029564-53029584 5 1.58e-04 CCAA TGGGCGGA GACGGCAG chr10:27444266-27444286 2 1.58e-04 G TGGGCGGA GCCTCACTTT chr19:44259782-44259802 6 1.58e-04 ACACG TGGGCGGA GTCTTGC chr6:27099772-27099792 4 2.07e-04 GGA AGGGCGGG CGTTGCCCG chr2:220083832-220083852 8 2.07e-04 CGTGCCC AGGGCGGG AAATC chr19:49631521-49631541 11 2.07e-04 CTTAGCAGGG AGGGCGGG AC chr10:121355353-12135537 6 2.39e-04 GGCGC TAGGCGGG TGTTTCT chr20:61427683-61427703 6 2.88e-04 CGCGC GGGGCGGA GCAGGGC chr17:37213244-37213264 8 3.20e-04 AAAAGCG TGGGCGTG CCTTG chr8:120868151-120868171 9 3.20e-04 GGCGGCCA TGGGCGTG TTTC chr4:6675686-6675706 10 4.00e-04 AGGACCGCT GAGGCGGG AGC chr2:203736496-203736516 7 4.00e-04 CTGCGG GAGGCGGG AGATTT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGGG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr17:33700721-33700741 5e-05 4_[+2]_8 chr2:71503661-71503681 5e-05 10_[+2]_2 chr14:105487520-10548754 0.00013 5_[+2]_7 chr2:219773842-219773862 0.00013 2_[+2]_10 chr1:12123306-12123326 0.00013 2_[+2]_10 chr6:83775642-83775662 0.00013 11_[+2]_1 chr13:53029564-53029584 0.00016 4_[+2]_8 chr10:27444266-27444286 0.00016 1_[+2]_11 chr19:44259782-44259802 0.00016 5_[+2]_7 chr6:27099772-27099792 0.00021 3_[+2]_9 chr2:220083832-220083852 0.00021 7_[+2]_5 chr19:49631521-49631541 0.00021 10_[+2]_2 chr10:121355353-12135537 0.00024 5_[+2]_7 chr20:61427683-61427703 0.00029 5_[+2]_7 chr17:37213244-37213264 0.00032 7_[+2]_5 chr8:120868151-120868171 0.00032 8_[+2]_4 chr4:6675686-6675706 0.0004 9_[+2]_3 chr2:203736496-203736516 0.0004 6_[+2]_6 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGGG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF KGGGCGGG width=8 seqs=18 chr17:33700721-33700741 ( 5) TGGGCGGG 1 chr2:71503661-71503681 ( 11) TGGGCGGG 1 chr14:105487520-10548754 ( 6) GGGGCGGG 1 chr2:219773842-219773862 ( 3) GGGGCGGG 1 chr1:12123306-12123326 ( 3) GGGGCGGG 1 chr6:83775642-83775662 ( 12) GGGGCGGG 1 chr13:53029564-53029584 ( 5) TGGGCGGA 1 chr10:27444266-27444286 ( 2) TGGGCGGA 1 chr19:44259782-44259802 ( 6) TGGGCGGA 1 chr6:27099772-27099792 ( 4) AGGGCGGG 1 chr2:220083832-220083852 ( 8) AGGGCGGG 1 chr19:49631521-49631541 ( 11) AGGGCGGG 1 chr10:121355353-12135537 ( 6) TAGGCGGG 1 chr20:61427683-61427703 ( 6) GGGGCGGA 1 chr17:37213244-37213264 ( 8) TGGGCGTG 1 chr8:120868151-120868171 ( 9) TGGGCGTG 1 chr4:6675686-6675706 ( 10) GAGGCGGG 1 chr2:203736496-203736516 ( 7) GAGGCGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGGG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.6233 E= 2.8e+002 -23 -1081 34 116 -23 -1081 144 -1081 -1081 -1081 170 -1081 -1081 -1081 170 -1081 -1081 174 -1081 -1081 -1081 -1081 170 -1081 -1081 -1081 153 -84 18 -1081 134 -1081 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGGG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 18 E= 2.8e+002 0.166667 0.000000 0.388889 0.444444 0.166667 0.000000 0.833333 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.888889 0.111111 0.222222 0.000000 0.777778 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif KGGGCGGG MEME-2 regular expression -------------------------------------------------------------------------------- [TG]GGGCGG[GA] -------------------------------------------------------------------------------- Time 3.83 secs. ******************************************************************************** ******************************************************************************** MOTIF ATTGGCTG MEME-3 width = 8 sites = 5 llr = 56 E-value = 2.1e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif ATTGGCTG MEME-3 Description -------------------------------------------------------------------------------- Simplified A a::::::: pos.-specific C :::::a:: probability G :::aa::a matrix T :aa:::a: bits 2.4 *** * 2.1 *** * 1.9 *** * 1.6 ******** Relative 1.4 ******** Entropy 1.2 ******** (16.2 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel ATTGGCTG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTGGCTG MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr16:89883083-89883103 1 1.32e-05 . ATTGGCTG CGGCCAGGCG chr19:47359439-47359459 6 1.32e-05 TCGTG ATTGGCTG CCCTTGG chr1:200589890-200589910 7 1.32e-05 CTTCTG ATTGGCTG CTGGGC chr6:24775581-24775601 9 1.32e-05 CGCTTCCT ATTGGCTG GCTG chr12:6960471-6960491 12 1.32e-05 CCCTGACCCT ATTGGCTG A -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTGGCTG MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr16:89883083-89883103 1.3e-05 [+3]_12 chr19:47359439-47359459 1.3e-05 5_[+3]_7 chr1:200589890-200589910 1.3e-05 6_[+3]_6 chr6:24775581-24775601 1.3e-05 8_[+3]_4 chr12:6960471-6960491 1.3e-05 11_[+3]_1 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTGGCTG MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ATTGGCTG width=8 seqs=5 chr16:89883083-89883103 ( 1) ATTGGCTG 1 chr19:47359439-47359459 ( 6) ATTGGCTG 1 chr1:200589890-200589910 ( 7) ATTGGCTG 1 chr6:24775581-24775601 ( 9) ATTGGCTG 1 chr12:6960471-6960491 ( 12) ATTGGCTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTGGCTG MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.77541 E= 2.1e+001 235 -897 -897 -897 -897 -897 -897 233 -897 -897 -897 233 -897 -897 170 -897 -897 -897 170 -897 -897 174 -897 -897 -897 -897 -897 233 -897 -897 170 -897 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTGGCTG MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 5 E= 2.1e+001 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATTGGCTG MEME-3 regular expression -------------------------------------------------------------------------------- ATTGGCTG -------------------------------------------------------------------------------- Time 4.55 secs. ******************************************************************************** ******************************************************************************** MOTIF AAAGAAAA MEME-4 width = 8 sites = 4 llr = 44 E-value = 2.9e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif AAAGAAAA MEME-4 Description -------------------------------------------------------------------------------- Simplified A a8a3aa8a pos.-specific C ::::::3: probability G :::8:::: matrix T :3:::::: bits 2.4 * * ** * 2.1 * * ** * 1.9 * * ** * 1.6 *** ** * Relative 1.4 *** **** Entropy 1.2 *** **** (15.7 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel AAAGAAAA consensus T A C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGAAAA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:9614137-9614157 1 3.41e-06 . aaagaaaa gcggccggct chr21:33651350-33651370 12 5.59e-06 GCGCCATGGG AAAAAAAA C chr20:42295721-42295741 2 9.04e-06 G ATAGAAAA GTGCTTCAAC chr4:81136750-81136770 5 1.42e-05 CGGG AAAGAACA AACTATTA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGAAAA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:9614137-9614157 3.4e-06 [+4]_12 chr21:33651350-33651370 5.6e-06 11_[+4]_1 chr20:42295721-42295741 9e-06 1_[+4]_11 chr4:81136750-81136770 1.4e-05 4_[+4]_8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGAAAA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF AAAGAAAA width=8 seqs=4 chr2:9614137-9614157 ( 1) AAAGAAAA 1 chr21:33651350-33651370 ( 12) AAAAAAAA 1 chr20:42295721-42295741 ( 2) ATAGAAAA 1 chr4:81136750-81136770 ( 5) AAAGAACA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGAAAA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.4021 E= 2.9e+002 235 -865 -865 -865 193 -865 -865 33 235 -865 -865 -865 35 -865 129 -865 235 -865 -865 -865 235 -865 -865 -865 193 -26 -865 -865 235 -865 -865 -865 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGAAAA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 2.9e+002 1.000000 0.000000 0.000000 0.000000 0.750000 0.000000 0.000000 0.250000 1.000000 0.000000 0.000000 0.000000 0.250000 0.000000 0.750000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.750000 0.250000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif AAAGAAAA MEME-4 regular expression -------------------------------------------------------------------------------- A[AT]A[GA]AA[AC]A -------------------------------------------------------------------------------- Time 5.29 secs. ******************************************************************************** ******************************************************************************** MOTIF CVVCCAAT MEME-5 width = 8 sites = 11 llr = 94 E-value = 4.5e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif CVVCCAAT MEME-5 Description -------------------------------------------------------------------------------- Simplified A :33:3aa: pos.-specific C a33a7::: probability G :55::::: matrix T :::::::a bits 2.4 *** 2.1 *** 1.9 *** 1.6 * * *** Relative 1.4 * * *** Entropy 1.2 * ***** (12.3 bits) 0.9 * ***** 0.7 * ***** 0.5 * ***** 0.2 ******** 0.0 -------- Multilevel CGGCCAAT consensus AA A sequence CC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CVVCCAAT MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr16:23690131-23690151 3 1.92e-05 CG CGGCCAAT CAGTGGCGCG chr21:32931503-32931523 10 4.36e-05 GCCTCCGGC CAGCCAAT CCG chr19:40728079-40728099 13 4.36e-05 GACCGGAATT CGACCAAT chr4:1873011-1873031 10 4.36e-05 CGAGCGCGG CAGCCAAT CAG chr8:73920905-73920925 12 1.01e-04 CCTAGACTGG CGGCAAAT T chr16:4635653-4635673 4 1.01e-04 CTG CGGCAAAT CACTCTTGG chrX:133931372-133931392 8 1.01e-04 ACCCTGG CGCCCAAT TTTGA chr12:77459385-77459405 11 1.41e-04 ATTTGAGAAT CCACCAAT CA chr3:52188447-52188467 13 1.41e-04 CCCCCAACGG CCACCAAT chr15:90118664-90118684 3 1.89e-04 CT CCCCCAAT AGCAGCAGTT chr10:124639236-12463925 6 2.05e-04 GTTCT CACCAAAT CCAGAAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CVVCCAAT MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr16:23690131-23690151 1.9e-05 2_[+5]_10 chr21:32931503-32931523 4.4e-05 9_[+5]_3 chr19:40728079-40728099 4.4e-05 12_[+5] chr4:1873011-1873031 4.4e-05 9_[+5]_3 chr8:73920905-73920925 0.0001 11_[+5]_1 chr16:4635653-4635673 0.0001 3_[+5]_9 chrX:133931372-133931392 0.0001 7_[+5]_5 chr12:77459385-77459405 0.00014 10_[+5]_2 chr3:52188447-52188467 0.00014 12_[+5] chr15:90118664-90118684 0.00019 2_[+5]_10 chr10:124639236-12463925 0.0002 5_[+5]_7 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CVVCCAAT MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CVVCCAAT width=8 seqs=11 chr16:23690131-23690151 ( 3) CGGCCAAT 1 chr21:32931503-32931523 ( 10) CAGCCAAT 1 chr19:40728079-40728099 ( 13) CGACCAAT 1 chr4:1873011-1873031 ( 10) CAGCCAAT 1 chr8:73920905-73920925 ( 12) CGGCAAAT 1 chr16:4635653-4635673 ( 4) CGGCAAAT 1 chrX:133931372-133931392 ( 8) CGCCCAAT 1 chr12:77459385-77459405 ( 11) CCACCAAT 1 chr3:52188447-52188467 ( 13) CCACCAAT 1 chr15:90118664-90118684 ( 3) CCCCCAAT 1 chr10:124639236-12463925 ( 6) CACCAAAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CVVCCAAT MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.75266 E= 4.5e+002 -1010 174 -1010 -1010 48 -13 57 -1010 48 -13 57 -1010 -1010 174 -1010 -1010 48 128 -1010 -1010 235 -1010 -1010 -1010 235 -1010 -1010 -1010 -1010 -1010 -1010 233 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CVVCCAAT MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 11 E= 4.5e+002 0.000000 1.000000 0.000000 0.000000 0.272727 0.272727 0.454545 0.000000 0.272727 0.272727 0.454545 0.000000 0.000000 1.000000 0.000000 0.000000 0.272727 0.727273 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CVVCCAAT MEME-5 regular expression -------------------------------------------------------------------------------- C[GAC][GAC]C[CA]AAT -------------------------------------------------------------------------------- Time 6.54 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:175850698-175850718 6.39e-01 20 chr20:3776882-3776902 5.14e-01 20 chrX:53448903-53448923 2.67e-03 10_[+1(2.82e-05)]_2 chr10:70811279-70811299 6.33e-01 20 chr6:111135774-111135794 9.49e-01 20 chr12:99038758-99038778 8.89e-01 20 chr10:70231524-70231544 9.94e-01 20 chr19:44259782-44259802 9.62e-02 20 chr2:200775880-200775900 6.55e-01 20 chr19:55852813-55852833 6.95e-01 20 chr19:47634506-47634526 6.74e-01 20 chr12:69140624-69140644 4.16e-01 20 chr6:27807693-27807713 9.88e-03 8_[+1(2.13e-05)]_4 chrX:14891180-14891200 7.33e-01 20 chr19:30302873-30302893 6.47e-01 20 chrX:100353153-100353173 3.14e-01 20 chr2:209176807-209176827 1.44e-01 20 chr18:51884277-51884297 4.23e-03 12_[+1(2.13e-05)] chr12:56110276-56110296 3.60e-01 20 chr4:184425789-184425809 4.91e-01 20 chr17:71187800-71187820 1.93e-02 20 chr8:95487328-95487348 7.95e-02 20 chr11:6627493-6627513 4.85e-01 20 chrX:133931372-133931392 1.32e-01 20 chr4:1873011-1873031 3.28e-02 9_[+5(4.36e-05)]_3 chr6:106958663-106958683 8.57e-02 20 chr3:186857245-186857265 3.22e-02 20 chr17:26926038-26926058 9.98e-01 20 chr6:167412551-167412571 8.32e-02 20 chr10:124639236-12463925 5.29e-02 20 chr1:155246988-155247008 5.56e-01 20 chr20:42295721-42295741 1.08e-03 1_[+4(9.04e-06)]_11 chr18:47901424-47901444 6.23e-01 20 chr6:26218009-26218029 2.84e-01 20 chr4:154265801-154265821 3.14e-02 20 chr8:67525492-67525512 9.34e-01 20 chr1:207818399-207818419 1.16e-01 20 chr8:27695331-27695351 2.64e-01 20 chr3:160167766-160167786 6.81e-01 20 chr21:33651350-33651370 1.07e-02 11_[+4(5.59e-06)]_1 chr6:165033920-165033940 1.98e-02 20 chr5:141704708-141704728 8.21e-01 20 chr2:97001532-97001552 5.91e-03 2_[+1(4.45e-05)]_10 chr12:2986332-2986352 7.22e-01 20 chr10:64028437-64028457 7.66e-01 20 chr10:129924725-12992474 1.90e-02 1_[+1(4.45e-05)]_11 chr6:83775642-83775662 1.87e-01 20 chrX:150151636-150151656 3.10e-01 20 chr16:23690131-23690151 7.63e-03 2_[+5(1.92e-05)]_10 chrX:69509929-69509949 2.58e-01 20 chr6:27862299-27862319 5.23e-01 20 chr8:101158032-101158052 8.19e-02 20 chr16:67281550-67281570 7.79e-01 20 chr20:60697408-60697428 1.05e-01 20 chr16:4635653-4635673 3.36e-02 20 chr17:34257790-34257810 5.05e-02 12_[+1(6.80e-05)] chr5:159848823-159848843 6.40e-02 20 chr10:60027939-60027959 1.79e-01 20 chr2:69664147-69664167 4.63e-01 20 chr13:45683006-45683026 8.27e-01 20 chr9:35665205-35665225 2.62e-02 4_[+1(4.45e-05)]_8 chr19:40728079-40728099 2.14e-03 12_[+5(4.36e-05)] chr11:134093882-13409390 7.62e-01 20 chr11:74204143-74204163 7.73e-03 8_[+1(4.45e-05)]_4 chr5:72144831-72144851 6.64e-01 20 chr12:105724319-10572433 8.85e-01 20 chr9:36572849-36572869 8.77e-02 20 chr5:149737663-149737683 8.41e-01 20 chr4:178230999-178231019 2.63e-02 3_[+1(8.05e-05)]_9 chr5:138729063-138729083 3.93e-01 20 chr2:242626271-242626291 1.50e-01 20 chr16:31044163-31044183 5.15e-01 20 chr15:68346438-68346458 6.69e-02 20 chr7:36429431-36429451 5.95e-03 11_[+1(2.82e-05)]_1 chrX:71458867-71458887 5.50e-01 20 chr1:68962786-68962806 4.77e-01 20 chr1:156542338-156542358 4.81e-02 [+1(8.95e-05)]_12 chr8:124084907-124084927 1.42e-01 20 chr1:12123306-12123326 1.87e-04 11_[+1(9.83e-05)]_1 chr16:433526-433546 2.85e-01 20 chr19:49631521-49631541 1.20e-01 20 chr11:13485247-13485267 9.49e-01 20 chr11:58912237-58912257 3.84e-02 3_[+1(4.45e-05)]_9 chr5:59995973-59995993 1.99e-02 11_[+1(8.95e-05)]_1 chr10:18949027-18949047 4.63e-01 20 chr19:53971329-53971349 5.27e-01 20 chr16:2510080-2510100 8.96e-01 20 chr9:21802528-21802548 3.30e-01 20 chr17:29158961-29158981 6.05e-01 20 chr20:44061137-44061157 6.27e-01 20 chr4:81136750-81136770 1.68e-02 4_[+4(1.42e-05)]_8 chr10:123733957-12373397 8.20e-01 20 chr19:53073867-53073887 3.24e-02 [+1(1.58e-05)]_12 chr3:88198761-88198781 2.19e-01 20 chr12:9800616-9800636 6.94e-01 20 chr7:45039398-45039418 9.98e-01 20 chr15:45695669-45695689 8.54e-01 20 chr6:126661263-126661283 3.66e-03 20 chr8:117886482-117886502 9.97e-01 20 chr19:16222173-16222193 9.27e-01 20 chr10:5454496-5454516 5.08e-01 20 chr1:28845116-28845136 1.25e-02 1_[+1(4.45e-05)]_11 chr16:3019250-3019270 4.35e-01 20 chr2:220083832-220083852 1.46e-02 20 chr5:612485-612505 3.19e-01 20 chr10:27444266-27444286 6.21e-02 20 chr1:45205479-45205499 3.06e-01 20 chr18:2571548-2571568 2.56e-03 2_[+1(3.43e-06)]_10 chr6:14254958-14254978 2.58e-03 [+1(1.23e-05)]_12 chr2:27579109-27579129 9.93e-01 20 chr16:67596271-67596291 1.50e-02 10_[+1(2.48e-05)]_2 chr6:100062739-100062759 3.01e-01 20 chr9:77567897-77567917 9.60e-01 20 chr2:9614137-9614157 3.04e-03 [+4(3.41e-06)]_12 chr19:37095662-37095682 4.43e-01 20 chr19:6199543-6199563 9.44e-01 20 chr12:6960471-6960491 3.93e-03 11_[+3(1.32e-05)]_1 chr2:26569684-26569704 5.02e-01 20 chr4:1723216-1723236 2.68e-02 2_[+1(2.13e-05)]_10 chr1:23857777-23857797 5.88e-01 20 chr2:17935392-17935412 7.76e-01 20 chr2:203736496-203736516 1.56e-01 20 chr19:53426324-53426344 2.70e-02 20 chr10:124907514-12490753 8.46e-03 12_[+1(2.48e-05)] chr8:73920905-73920925 8.78e-03 20 chr12:122110590-12211061 9.44e-01 20 chr16:46723558-46723578 3.53e-01 20 chr6:80714353-80714373 3.76e-03 8_[+1(2.82e-05)]_4 chr16:20817819-20817839 2.33e-01 20 chr20:35402215-35402235 2.69e-01 20 chr8:120868151-120868171 6.45e-02 20 chr17:79369041-79369061 9.76e-02 20 chr18:56338487-56338507 3.31e-02 20 chr22:36728967-36728987 7.74e-01 20 chr4:2243848-2243868 8.13e-01 20 chr6:24775581-24775601 3.74e-03 8_[+3(1.32e-05)]_4 chr1:109419563-109419583 3.10e-02 8_[+1(8.95e-05)]_4 chr1:176176446-176176466 3.20e-01 20 chr19:14247428-14247448 8.97e-01 20 chr19:54024324-54024344 9.48e-01 20 chr19:4909985-4910005 4.76e-01 20 chr1:160255024-160255044 2.05e-01 20 chr17:38703781-38703801 9.67e-01 20 chr22:39378394-39378414 5.46e-02 20 chr8:121881191-121881211 1.04e-02 7_[+1(9.83e-05)]_5 chr1:226496871-226496891 9.83e-01 20 chr13:53029564-53029584 3.88e-02 20 chr10:58121061-58121081 4.21e-01 20 chr17:30186444-30186464 1.90e-01 20 chr14:54863552-54863572 3.83e-02 [+1(3.34e-05)]_12 chr2:234763206-234763226 5.52e-01 20 chr16:838646-838666 3.16e-01 20 chr10:95256335-95256355 9.74e-01 20 chr2:71503661-71503681 5.20e-02 10_[+2(4.96e-05)]_2 chr2:25016316-25016336 1.03e-01 20 chr3:52188447-52188467 1.16e-01 20 chr6:27099772-27099792 8.64e-02 20 chr5:162887600-162887620 3.55e-02 8_[+1(8.05e-05)]_4 chr6:86388725-86388745 7.58e-03 10_[+1(2.82e-05)]_2 chr17:37558917-37558937 9.09e-01 20 chrX:118816798-118816818 4.48e-03 [+1(1.23e-05)]_12 chr2:136874575-136874595 6.26e-01 20 chr17:73268030-73268050 2.27e-01 20 chr1:93646257-93646277 8.60e-01 20 chr1:200589890-200589910 1.66e-02 6_[+3(1.32e-05)]_6 chr11:27384749-27384769 1.12e-02 20 chr17:6347734-6347754 2.41e-02 6_[+1(1.23e-05)]_6 chr16:85722570-85722590 8.76e-01 20 chr17:80674627-80674647 8.00e-01 20 chr7:158497458-158497478 9.78e-01 20 chr1:236768158-236768178 9.04e-01 20 chr1:26232069-26232089 3.04e-01 20 chr19:49224034-49224054 3.06e-01 20 chr8:28645498-28645518 6.84e-03 7_[+1(4.45e-05)]_5 chr12:98910391-98910411 3.74e-04 8_[+1(1.23e-05)]_4 chr4:15683212-15683232 9.01e-01 20 chr7:64734278-64734298 6.89e-01 20 chr19:47359439-47359459 1.02e-02 5_[+3(1.32e-05)]_7 chrX:48555147-48555167 5.96e-01 20 chr17:8113922-8113942 2.22e-02 2_[+1(1.58e-05)]_10 chr4:6675686-6675706 2.12e-01 20 chr2:10262783-10262803 1.57e-01 20 chr17:27760647-27760667 6.99e-01 20 chr17:37213244-37213264 1.54e-01 20 chr11:10562346-10562366 8.31e-03 8_[+1(5.33e-05)]_4 chr1:156265496-156265516 9.46e-03 20 chr1:36235580-36235600 3.07e-01 20 chr4:185654582-185654602 1.92e-02 20 chr4:129733265-129733285 4.06e-01 20 chr1:197115825-197115845 9.99e-01 20 chr20:23347175-23347195 6.38e-01 20 chr9:98273789-98273809 9.24e-01 20 chr5:169010738-169010758 6.55e-01 20 chr21:32931503-32931523 8.07e-02 9_[+5(4.36e-05)]_3 chr2:136776969-136776989 8.17e-01 20 chr5:112312256-112312276 5.86e-01 20 chr19:4535383-4535403 5.84e-01 20 chr6:166796594-166796614 9.20e-01 20 chr1:146967004-146967024 7.66e-02 20 chr17:42219286-42219306 2.30e-01 20 chr2:46095169-46095189 3.56e-01 20 chr6:26251126-26251146 4.38e-01 20 chr19:36391463-36391483 7.41e-02 20 chr5:36242424-36242444 5.77e-01 20 chr12:12849131-12849151 5.25e-02 20 chr19:11750585-11750605 4.53e-02 20 chr8:26435315-26435335 5.95e-01 20 chr6:90539490-90539510 3.36e-01 20 chr8:117887041-117887061 4.81e-01 20 chr17:33700721-33700741 2.02e-02 4_[+2(4.96e-05)]_8 chr20:61427683-61427703 2.76e-01 20 chr11:95523101-95523121 7.79e-02 20 chr19:50169200-50169220 2.32e-01 20 chr19:53869281-53869301 1.00e+00 20 chr12:49524630-49524650 9.85e-01 20 chr2:215674009-215674029 9.98e-01 20 chr5:137667536-137667556 7.75e-01 20 chr11:9595134-9595154 3.85e-02 11_[+1(1.58e-05)]_1 chr10:105128410-10512843 9.24e-01 20 chr19:11492058-11492078 4.76e-01 20 chr10:102820504-10282052 9.60e-01 20 chr20:25388325-25388345 7.01e-01 20 chr1:46049145-46049165 1.34e-01 20 chr2:219773842-219773862 5.76e-02 20 chr16:89883083-89883103 8.85e-03 [+3(1.32e-05)]_12 chr11:31832775-31832795 1.38e-01 20 chr21:38630662-38630682 9.83e-02 20 chr15:91498526-91498546 1.57e-01 20 chr17:33775873-33775893 6.15e-01 20 chr17:42263820-42263840 5.68e-01 20 chr7:99680324-99680344 2.86e-01 20 chr16:30645767-30645787 7.18e-01 20 chr1:46050425-46050445 7.75e-01 20 chr10:121355353-12135537 1.54e-01 20 chr2:231068216-231068236 6.66e-01 20 chr4:120987948-120987968 7.71e-01 20 chr16:28891326-28891346 1.86e-01 20 chr14:105487520-10548754 1.62e-01 20 chr12:120315114-12031513 3.54e-01 20 chr15:90118664-90118684 5.40e-02 20 chr19:50887590-50887610 8.75e-01 20 chr12:77459385-77459405 2.89e-03 20 chr17:1531838-1531858 8.56e-01 20 chr5:158385495-158385515 7.63e-01 20 chr19:984857-984877 1.85e-02 20 chr19:44079760-44079780 9.29e-01 20 chr19:17392654-17392674 9.79e-01 20 chr15:64673699-64673719 9.91e-01 20 chr21:47744354-47744374 1.55e-01 20 chr8:145743227-145743247 7.05e-01 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n04.farnam.hpc.yale.internal ********************************************************************************