******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/CREM.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr19:9649317-9649337 1.0000 20 chr7:93633684-93633704 1.0000 20 chr11:67374370-67374390 1.0000 20 chr1:32110257-32110277 1.0000 20 chr6:139456096-139456116 1.0000 20 chr3:52444042-52444062 1.0000 20 chr13:49822029-49822049 1.0000 20 chr1:243265068-243265088 1.0000 20 chr3:44771086-44771106 1.0000 20 chr1:47644914-47644934 1.0000 20 chrX:102024048-102024068 1.0000 20 chr11:77185429-77185449 1.0000 20 chr14:23775957-23775977 1.0000 20 chr4:110736651-110736671 1.0000 20 chr2:110962604-110962624 1.0000 20 chr16:86588812-86588832 1.0000 20 chr9:33076669-33076689 1.0000 20 chr9:111696391-111696411 1.0000 20 chr14:55738836-55738856 1.0000 20 chr14:36278581-36278601 1.0000 20 chr8:37605571-37605591 1.0000 20 chr6:34664734-34664754 1.0000 20 chr2:28114140-28114160 1.0000 20 chr8:95003876-95003896 1.0000 20 chr18:2571465-2571485 1.0000 20 chr9:134955299-134955319 1.0000 20 chr1:154600465-154600485 1.0000 20 chr19:50979544-50979564 1.0000 20 chr8:144623647-144623667 1.0000 20 chr16:48644198-48644218 1.0000 20 chr5:95297759-95297779 1.0000 20 chr14:100150240-10015026 1.0000 20 chr7:75795900-75795920 1.0000 20 chr2:74781573-74781593 1.0000 20 chr6:126661245-126661265 1.0000 20 chrX:102809889-102809909 1.0000 20 chr7:140624827-140624847 1.0000 20 chr14:24769033-24769053 1.0000 20 chr3:185000683-185000703 1.0000 20 chr4:119512855-119512875 1.0000 20 chr11:33369216-33369236 1.0000 20 chr19:57862613-57862633 1.0000 20 chr1:228296997-228297017 1.0000 20 chr15:42841000-42841020 1.0000 20 chr19:36103621-36103641 1.0000 20 chr3:130465680-130465700 1.0000 20 chr6:27706260-27706280 1.0000 20 chr7:45808672-45808692 1.0000 20 chr4:123073438-123073458 1.0000 20 chr2:19548195-19548215 1.0000 20 chr7:66309968-66309988 1.0000 20 chr20:47044875-47044895 1.0000 20 chr22:36761209-36761229 1.0000 20 chr7:150924438-150924458 1.0000 20 chr12:64616367-64616387 1.0000 20 chr1:1510281-1510301 1.0000 20 chr2:3605935-3605955 1.0000 20 chr2:190305806-190305826 1.0000 20 chr1:936278-936298 1.0000 20 chr13:45915376-45915396 1.0000 20 chr3:184053658-184053678 1.0000 20 chr2:96068439-96068459 1.0000 20 chr6:38607928-38607948 1.0000 20 chrX:48980222-48980242 1.0000 20 chr4:39367988-39368008 1.0000 20 chr7:65958573-65958593 1.0000 20 chr19:50862239-50862259 1.0000 20 chr6:15248975-15248995 1.0000 20 chr7:5553438-5553458 1.0000 20 chr8:92082270-92082290 1.0000 20 chr5:137673200-137673220 1.0000 20 chr18:2655163-2655183 1.0000 20 chr6:43027172-43027192 1.0000 20 chr4:103940857-103940877 1.0000 20 chr15:50716555-50716575 1.0000 20 chr16:58283851-58283871 1.0000 20 chr14:36789873-36789893 1.0000 20 chr22:19159172-19159192 1.0000 20 chr5:70751415-70751435 1.0000 20 chr2:130939149-130939169 1.0000 20 chrX:48659828-48659848 1.0000 20 chr12:76953506-76953526 1.0000 20 chr11:72433629-72433649 1.0000 20 chr3:45017732-45017752 1.0000 20 chr17:38083891-38083911 1.0000 20 chr16:81348506-81348526 1.0000 20 chr22:42078501-42078521 1.0000 20 chr6:109416644-109416664 1.0000 20 chr4:8430235-8430255 1.0000 20 chr11:10562768-10562788 1.0000 20 chr1:156698671-156698691 1.0000 20 chr5:36151276-36151296 1.0000 20 chr1:224180345-224180365 1.0000 20 chr16:20753140-20753160 1.0000 20 chr3:185304054-185304074 1.0000 20 chr7:23145312-23145332 1.0000 20 chr15:41047459-41047479 1.0000 20 chr16:67927143-67927163 1.0000 20 chr3:112280049-112280069 1.0000 20 chr1:714058-714078 1.0000 20 chr2:109335889-109335909 1.0000 20 chr19:47987500-47987520 1.0000 20 chr14:23388136-23388156 1.0000 20 chr1:32671243-32671263 1.0000 20 chr17:8152593-8152613 1.0000 20 chr7:102036799-102036819 1.0000 20 chr7:107204373-107204393 1.0000 20 chr16:71879838-71879858 1.0000 20 chr2:27712622-27712642 1.0000 20 chr14:32030594-32030614 1.0000 20 chr4:170533749-170533769 1.0000 20 chr5:173043752-173043772 1.0000 20 chr17:4607436-4607456 1.0000 20 chr2:39005321-39005341 1.0000 20 chr21:44527679-44527699 1.0000 20 chr5:78810426-78810446 1.0000 20 chr3:154042335-154042355 1.0000 20 chr4:164088084-164088104 1.0000 20 chr20:3801433-3801453 1.0000 20 chr9:135753693-135753713 1.0000 20 chr13:111805958-11180597 1.0000 20 chr7:73097899-73097919 1.0000 20 chr12:58138389-58138409 1.0000 20 chr8:66754804-66754824 1.0000 20 chr19:35225458-35225478 1.0000 20 chr2:65547666-65547686 1.0000 20 chr2:68290163-68290183 1.0000 20 chr5:180688142-180688162 1.0000 20 chr8:145747834-145747854 1.0000 20 chr3:51534013-51534033 1.0000 20 chr9:125027115-125027135 1.0000 20 chr9:119702085-119702105 1.0000 20 chr1:2344012-2344032 1.0000 20 chr5:1345287-1345307 1.0000 20 chr16:89126842-89126862 1.0000 20 chr20:42286159-42286179 1.0000 20 chr7:56019561-56019581 1.0000 20 chr17:17380285-17380305 1.0000 20 chr19:9546227-9546247 1.0000 20 chr9:86323116-86323136 1.0000 20 chr1:212662055-212662075 1.0000 20 chr5:140098481-140098501 1.0000 20 chr15:63481618-63481638 1.0000 20 chr1:70820711-70820731 1.0000 20 chr1:90593036-90593056 1.0000 20 chr17:7465235-7465255 1.0000 20 chr5:134074118-134074138 1.0000 20 chr16:70333066-70333086 1.0000 20 chr6:37400975-37400995 1.0000 20 chr5:180611316-180611336 1.0000 20 chr7:19748676-19748696 1.0000 20 chr17:27071420-27071440 1.0000 20 chr7:124569905-124569925 1.0000 20 chr6:13429782-13429802 1.0000 20 chr22:50946637-50946657 1.0000 20 chr1:228291043-228291063 1.0000 20 chr9:21832313-21832333 1.0000 20 chr16:67694773-67694793 1.0000 20 chr9:71394884-71394904 1.0000 20 chr4:120375866-120375886 1.0000 20 chr8:17104377-17104397 1.0000 20 chr3:10028534-10028554 1.0000 20 chr19:36036462-36036482 1.0000 20 chr7:44646090-44646110 1.0000 20 chr10:102027427-10202744 1.0000 20 chr4:57253663-57253683 1.0000 20 chr4:122745103-122745123 1.0000 20 chr18:158536-158556 1.0000 20 chr13:45563638-45563658 1.0000 20 chr9:6015639-6015659 1.0000 20 chr14:88851974-88851994 1.0000 20 chr10:113943521-11394354 1.0000 20 chr3:44754120-44754140 1.0000 20 chr2:135676181-135676201 1.0000 20 chr1:20834645-20834665 1.0000 20 chr17:15903017-15903037 1.0000 20 chr17:79093600-79093620 1.0000 20 chrX:47518545-47518565 1.0000 20 chr1:1655795-1655815 1.0000 20 chr3:101280643-101280663 1.0000 20 chr2:202507437-202507457 1.0000 20 chr2:220110180-220110200 1.0000 20 chr5:167578233-167578253 1.0000 20 chr9:138853281-138853301 1.0000 20 chr1:22379155-22379175 1.0000 20 chr2:101010820-101010840 1.0000 20 chr6:53213810-53213830 1.0000 20 chr8:21967216-21967236 1.0000 20 chr1:40626953-40626973 1.0000 20 chr17:4046959-4046979 1.0000 20 chrX:118699367-118699387 1.0000 20 chr7:99149742-99149762 1.0000 20 chr17:33914270-33914290 1.0000 20 chr6:32908879-32908899 1.0000 20 chr5:86708756-86708776 1.0000 20 chr10:124740139-12474015 1.0000 20 chr6:41888891-41888911 1.0000 20 chr12:110011036-11001105 1.0000 20 chr16:31128967-31128987 1.0000 20 chr19:18215343-18215363 1.0000 20 chr19:11616674-11616694 1.0000 20 chr11:66112580-66112600 1.0000 20 chr5:72861558-72861578 1.0000 20 chr11:64889650-64889670 1.0000 20 chr3:48488080-48488100 1.0000 20 chr1:1447429-1447449 1.0000 20 chr14:71067376-71067396 1.0000 20 chr2:170440851-170440871 1.0000 20 chr15:40861503-40861523 1.0000 20 chr17:42264273-42264293 1.0000 20 chr1:153395132-153395152 1.0000 20 chr6:27440232-27440252 1.0000 20 chrX:347710-347730 1.0000 20 chr20:18268851-18268871 1.0000 20 chr7:99097926-99097946 1.0000 20 chr16:87799588-87799608 1.0000 20 chr4:148605364-148605384 1.0000 20 chr6:167528170-167528190 1.0000 20 chr22:26879806-26879826 1.0000 20 chr14:105219451-10521947 1.0000 20 chr19:55987878-55987898 1.0000 20 chr9:27573825-27573845 1.0000 20 chr5:150080654-150080674 1.0000 20 chr8:10697394-10697414 1.0000 20 chr20:23338769-23338789 1.0000 20 chr12:133656798-13365681 1.0000 20 chr3:142166869-142166889 1.0000 20 chr4:54232239-54232259 1.0000 20 chrX:24711897-24711917 1.0000 20 chr5:139042447-139042467 1.0000 20 chr14:61447813-61447833 1.0000 20 chr19:56015282-56015302 1.0000 20 chr11:4116003-4116023 1.0000 20 chr1:89149913-89149933 1.0000 20 chr8:146277855-146277875 1.0000 20 chr3:196594756-196594776 1.0000 20 chr19:16683315-16683335 1.0000 20 chrX:48334527-48334547 1.0000 20 chr20:33265047-33265067 1.0000 20 chr11:63706288-63706308 1.0000 20 chr10:111971062-11197108 1.0000 20 chr3:25706526-25706546 1.0000 20 chr22:47158446-47158466 1.0000 20 chr19:56028467-56028487 1.0000 20 chr9:139760875-139760895 1.0000 20 chr3:156544035-156544055 1.0000 20 chr16:88772871-88772891 1.0000 20 chr2:132250624-132250644 1.0000 20 chr18:46458711-46458731 1.0000 20 chr7:156685981-156686001 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_CREM/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/CREM.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.183 C 0.325 G 0.317 T 0.175 Background letter frequencies (from file dataset with add-one prior applied): A 0.183 C 0.325 G 0.317 T 0.175 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TGACGTCA MEME-1 width = 8 sites = 76 llr = 613 E-value = 1.0e-096 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGACGTCA MEME-1 Description -------------------------------------------------------------------------------- Simplified A 1:9:::18 pos.-specific C :1:a:181 probability G :91:9:1: matrix T 9::::9:1 bits 2.5 2.3 2.0 * 1.8 * * * Relative 1.5 * ** * * Entropy 1.3 * **** * (11.6 bits) 1.0 ****** * 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel TGACGTCA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr10:111971062-11197108 11 1.09e-05 CAGCCTCTTC TGACGTCA CG chr8:10697394-10697414 6 1.09e-05 GCTGG TGACGTCA GTAGCGC chr17:33914270-33914290 8 1.09e-05 CGTTCTC TGACGTCA GAGTT chrX:118699367-118699387 5 1.09e-05 GAAA TGACGTCA CGAGTGCG chr17:4046959-4046979 7 1.09e-05 CGCCGA TGACGTCA CGCTCG chr1:22379155-22379175 2 1.09e-05 C TGACGTCA GGTGCGTGCC chr14:88851974-88851994 7 1.09e-05 GCGCCG TGACGTCA CAATAG chr4:122745103-122745123 9 1.09e-05 CGCGGCCT TGACGTCA TTCA chr7:44646090-44646110 10 1.09e-05 GCGGCTCTG TGACGTCA CGA chr3:10028534-10028554 5 1.09e-05 ACGT TGACGTCA CGTCGTGG chr1:228291043-228291063 3 1.09e-05 CG TGACGTCA CTCCCGCGCC chr17:27071420-27071440 1 1.09e-05 . TGACGTCA AGCCCCGAGG chr20:42286159-42286179 8 1.09e-05 CCCACGG TGACGTCA GGGAC chr8:66754804-66754824 2 1.09e-05 G TGACGTCA GCGGGCCGCG chr1:714058-714078 10 1.09e-05 CCGCCCTTG TGACGTCA CGG chr1:224180345-224180365 1 1.09e-05 . TGACGTCA CGGAAGGCGC chr4:8430235-8430255 4 1.09e-05 CCC TGACGTCA TCGAACCGC chr4:39367988-39368008 10 1.09e-05 GCGCGGTGA TGACGTCA GGA chr7:66309968-66309988 7 1.09e-05 CTTCGC TGACGTCA CAGGCG chr19:36103621-36103641 9 1.09e-05 CGCGCCCG TGACGTCA GAGG chr4:119512855-119512875 10 1.09e-05 CGCCCTCCG TGACGTCA CAA chr2:74781573-74781593 6 1.09e-05 GCATA TGACGTCA CGCGCAG chr16:48644198-48644218 10 1.09e-05 GACGGAAGT TGACGTCA CCC chr8:37605571-37605591 6 1.09e-05 CGAAA TGACGTCA CGAGCGC chr14:55738836-55738856 13 1.09e-05 CGTGTGTCTG TGACGTCA chrX:102024048-102024068 6 1.09e-05 TAACC TGACGTCA TATTAGC chr3:44771086-44771106 8 1.09e-05 GGACTGC TGACGTCA CGCCG chr3:101280643-101280663 4 1.70e-05 CTG TGACGTAA AAAGCAGCG chr17:8152593-8152613 5 1.70e-05 CGGA TGACGTAA CAAACGCG chr14:36789873-36789893 10 1.70e-05 GCTTGGCGA TGACGTAA GAC chr19:56028467-56028487 6 4.94e-05 ACCCA TGACGTCT CGAGGCT chr12:110011036-11001105 4 4.94e-05 TGG AGACGTCA CCTGACGGT chr10:102027427-10202744 11 4.94e-05 CGCAACAATC AGACGTCA GC chr5:180688142-180688162 9 4.94e-05 ACGCAAAA TGACGTCT CGCT chr1:32110257-32110277 9 4.94e-05 GTCCTTCA TGACGTGA GCAG chr11:67374370-67374390 4 4.94e-05 GCG TGACGTCT TTCCTGCGC chr7:56019561-56019581 2 6.96e-05 G TGACGCCA TCCCGCTGCG chr16:67927143-67927163 10 6.96e-05 GCGCTGTGA TGACGCCA CGA chr22:19159172-19159192 2 6.96e-05 G TGACGCCA TCAGCGCGCG chr2:110962604-110962624 6 6.96e-05 GAAGG TGACGCCA TCGATGT chr1:154600465-154600485 1 7.59e-05 . TGACATCA TTGGCGCGCC chr5:1345287-1345307 5 1.01e-04 TGTG TGACGTTA CCCGCCCG chr22:42078501-42078521 3 1.01e-04 AG TGACGTCC AGGGCCAGCC chr5:78810426-78810446 4 1.18e-04 AGC TCACGTCA CCGAGGTGC chr8:92082270-92082290 5 1.18e-04 CGCC TCACGTCA GGGCCAAG chr12:58138389-58138409 10 1.37e-04 ACAAAACAA TGGCGTCA TCG chr19:50862239-50862259 4 1.37e-04 CTA TGGCGTCA TGGTGATGG chr7:93633684-93633704 9 1.37e-04 CCGGATGA TGGCGTCA CCAC chr7:102036799-102036819 4 1.48e-04 CTG TGTCGTCA TACTTGCGC chr8:95003876-95003896 6 1.71e-04 AAATA TGACCTCA GCGCAGG chr6:34664734-34664754 8 1.71e-04 CCCCGCG TGACCTCA CCGCT chr11:4116003-4116023 1 1.95e-04 . TAACGTCA TTCGAACCCC chr10:113943521-11394354 10 1.95e-04 GCACCCTGA TGACGCAA CCG chr9:21832313-21832333 8 1.95e-04 TATGCTC TGATGTCA AGTAT chr17:4607436-4607456 4 1.95e-04 CGA TGACGCAA ACACACCGC chr11:10562768-10562788 9 1.95e-04 CACCTCTG TGACGCAA AGCC chr1:936278-936298 1 1.95e-04 . TGACGCAA GCCTGCTGGG chr17:7465235-7465255 2 2.09e-04 G TGACGTAC TAATCGTGCG chr5:167578233-167578253 13 2.19e-04 CAGATCTTAC TCACGTAA chr17:15903017-15903037 1 2.80e-04 . TGACGTCG GGGCGCGTCA chr17:17380285-17380305 9 2.80e-04 CGCGGTGG TGACGTGT AGAG chr7:23145312-23145332 9 2.80e-04 CGCCACTG TGACGTGT CAGG chr8:17104377-17104397 13 3.46e-04 CGCTAGATGA TGACGCGA chr19:35225458-35225478 3 3.46e-04 TT AGACGCCA GCCACAGTTG chr16:88772871-88772891 3 3.73e-04 TC CGACGTCA TCGGGGCGCG chr20:47044875-47044895 9 3.98e-04 AGCTCAGA TGACATCT CAGG chr22:26879806-26879826 9 4.61e-04 CGCGGCGA TGACGTGC CGAG chr3:45017732-45017752 7 4.61e-04 CGCAGA TGACGTGC GGCTCG chr6:167528170-167528190 5 5.59e-04 GTGC ACACGTCA CCCTTTTT chr6:27440232-27440252 9 5.59e-04 TCAGCAGC ATACGTCA CACA chr9:119702085-119702105 3 5.59e-04 AA ATACgtca tgggctgcat chr18:2655163-2655183 13 6.72e-04 AGCGCCCTTC TGACGTTC chr13:49822029-49822049 11 6.72e-04 GTCAAGCTTG AGGCGTCA TC chr16:31128967-31128987 1 9.11e-04 . TGGCGTCC GATTCTGGCG chrX:347710-347730 7 1.06e-03 CGACGA TGTCATCA CGAGGC chr1:20834645-20834665 9 1.21e-03 CCCAGCGA TGACGCAC GACG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr10:111971062-11197108 1.1e-05 10_[+1]_2 chr8:10697394-10697414 1.1e-05 5_[+1]_7 chr17:33914270-33914290 1.1e-05 7_[+1]_5 chrX:118699367-118699387 1.1e-05 4_[+1]_8 chr17:4046959-4046979 1.1e-05 6_[+1]_6 chr1:22379155-22379175 1.1e-05 1_[+1]_11 chr14:88851974-88851994 1.1e-05 6_[+1]_6 chr4:122745103-122745123 1.1e-05 8_[+1]_4 chr7:44646090-44646110 1.1e-05 9_[+1]_3 chr3:10028534-10028554 1.1e-05 4_[+1]_8 chr1:228291043-228291063 1.1e-05 2_[+1]_10 chr17:27071420-27071440 1.1e-05 [+1]_12 chr20:42286159-42286179 1.1e-05 7_[+1]_5 chr8:66754804-66754824 1.1e-05 1_[+1]_11 chr1:714058-714078 1.1e-05 9_[+1]_3 chr1:224180345-224180365 1.1e-05 [+1]_12 chr4:8430235-8430255 1.1e-05 3_[+1]_9 chr4:39367988-39368008 1.1e-05 9_[+1]_3 chr7:66309968-66309988 1.1e-05 6_[+1]_6 chr19:36103621-36103641 1.1e-05 8_[+1]_4 chr4:119512855-119512875 1.1e-05 9_[+1]_3 chr2:74781573-74781593 1.1e-05 5_[+1]_7 chr16:48644198-48644218 1.1e-05 9_[+1]_3 chr8:37605571-37605591 1.1e-05 5_[+1]_7 chr14:55738836-55738856 1.1e-05 12_[+1] chrX:102024048-102024068 1.1e-05 5_[+1]_7 chr3:44771086-44771106 1.1e-05 7_[+1]_5 chr3:101280643-101280663 1.7e-05 3_[+1]_9 chr17:8152593-8152613 1.7e-05 4_[+1]_8 chr14:36789873-36789893 1.7e-05 9_[+1]_3 chr19:56028467-56028487 4.9e-05 5_[+1]_7 chr12:110011036-11001105 4.9e-05 3_[+1]_9 chr10:102027427-10202744 4.9e-05 10_[+1]_2 chr5:180688142-180688162 4.9e-05 8_[+1]_4 chr1:32110257-32110277 4.9e-05 8_[+1]_4 chr11:67374370-67374390 4.9e-05 3_[+1]_9 chr7:56019561-56019581 7e-05 1_[+1]_11 chr16:67927143-67927163 7e-05 9_[+1]_3 chr22:19159172-19159192 7e-05 1_[+1]_11 chr2:110962604-110962624 7e-05 5_[+1]_7 chr1:154600465-154600485 7.6e-05 [+1]_12 chr5:1345287-1345307 0.0001 4_[+1]_8 chr22:42078501-42078521 0.0001 2_[+1]_10 chr5:78810426-78810446 0.00012 3_[+1]_9 chr8:92082270-92082290 0.00012 4_[+1]_8 chr12:58138389-58138409 0.00014 9_[+1]_3 chr19:50862239-50862259 0.00014 3_[+1]_9 chr7:93633684-93633704 0.00014 8_[+1]_4 chr7:102036799-102036819 0.00015 3_[+1]_9 chr8:95003876-95003896 0.00017 5_[+1]_7 chr6:34664734-34664754 0.00017 7_[+1]_5 chr11:4116003-4116023 0.00019 [+1]_12 chr10:113943521-11394354 0.00019 9_[+1]_3 chr9:21832313-21832333 0.00019 7_[+1]_5 chr17:4607436-4607456 0.00019 3_[+1]_9 chr11:10562768-10562788 0.00019 8_[+1]_4 chr1:936278-936298 0.00019 [+1]_12 chr17:7465235-7465255 0.00021 1_[+1]_11 chr5:167578233-167578253 0.00022 12_[+1] chr17:15903017-15903037 0.00028 [+1]_12 chr17:17380285-17380305 0.00028 8_[+1]_4 chr7:23145312-23145332 0.00028 8_[+1]_4 chr8:17104377-17104397 0.00035 12_[+1] chr19:35225458-35225478 0.00035 2_[+1]_10 chr16:88772871-88772891 0.00037 2_[+1]_10 chr20:47044875-47044895 0.0004 8_[+1]_4 chr22:26879806-26879826 0.00046 8_[+1]_4 chr3:45017732-45017752 0.00046 6_[+1]_6 chr6:167528170-167528190 0.00056 4_[+1]_8 chr6:27440232-27440252 0.00056 8_[+1]_4 chr9:119702085-119702105 0.00056 2_[+1]_10 chr18:2655163-2655183 0.00067 12_[+1] chr13:49822029-49822049 0.00067 10_[+1]_2 chr16:31128967-31128987 0.00091 [+1]_12 chrX:347710-347730 0.0011 6_[+1]_6 chr1:20834645-20834665 0.0012 8_[+1]_4 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGACGTCA width=8 seqs=76 chr10:111971062-11197108 ( 11) TGACGTCA 1 chr8:10697394-10697414 ( 6) TGACGTCA 1 chr17:33914270-33914290 ( 8) TGACGTCA 1 chrX:118699367-118699387 ( 5) TGACGTCA 1 chr17:4046959-4046979 ( 7) TGACGTCA 1 chr1:22379155-22379175 ( 2) TGACGTCA 1 chr14:88851974-88851994 ( 7) TGACGTCA 1 chr4:122745103-122745123 ( 9) TGACGTCA 1 chr7:44646090-44646110 ( 10) TGACGTCA 1 chr3:10028534-10028554 ( 5) TGACGTCA 1 chr1:228291043-228291063 ( 3) TGACGTCA 1 chr17:27071420-27071440 ( 1) TGACGTCA 1 chr20:42286159-42286179 ( 8) TGACGTCA 1 chr8:66754804-66754824 ( 2) TGACGTCA 1 chr1:714058-714078 ( 10) TGACGTCA 1 chr1:224180345-224180365 ( 1) TGACGTCA 1 chr4:8430235-8430255 ( 4) TGACGTCA 1 chr4:39367988-39368008 ( 10) TGACGTCA 1 chr7:66309968-66309988 ( 7) TGACGTCA 1 chr19:36103621-36103641 ( 9) TGACGTCA 1 chr4:119512855-119512875 ( 10) TGACGTCA 1 chr2:74781573-74781593 ( 6) TGACGTCA 1 chr16:48644198-48644218 ( 10) TGACGTCA 1 chr8:37605571-37605591 ( 6) TGACGTCA 1 chr14:55738836-55738856 ( 13) TGACGTCA 1 chrX:102024048-102024068 ( 6) TGACGTCA 1 chr3:44771086-44771106 ( 8) TGACGTCA 1 chr3:101280643-101280663 ( 4) TGACGTAA 1 chr17:8152593-8152613 ( 5) TGACGTAA 1 chr14:36789873-36789893 ( 10) TGACGTAA 1 chr19:56028467-56028487 ( 6) TGACGTCT 1 chr12:110011036-11001105 ( 4) AGACGTCA 1 chr10:102027427-10202744 ( 11) AGACGTCA 1 chr5:180688142-180688162 ( 9) TGACGTCT 1 chr1:32110257-32110277 ( 9) TGACGTGA 1 chr11:67374370-67374390 ( 4) TGACGTCT 1 chr7:56019561-56019581 ( 2) TGACGCCA 1 chr16:67927143-67927163 ( 10) TGACGCCA 1 chr22:19159172-19159192 ( 2) TGACGCCA 1 chr2:110962604-110962624 ( 6) TGACGCCA 1 chr1:154600465-154600485 ( 1) TGACATCA 1 chr5:1345287-1345307 ( 5) TGACGTTA 1 chr22:42078501-42078521 ( 3) TGACGTCC 1 chr5:78810426-78810446 ( 4) TCACGTCA 1 chr8:92082270-92082290 ( 5) TCACGTCA 1 chr12:58138389-58138409 ( 10) TGGCGTCA 1 chr19:50862239-50862259 ( 4) TGGCGTCA 1 chr7:93633684-93633704 ( 9) TGGCGTCA 1 chr7:102036799-102036819 ( 4) TGTCGTCA 1 chr8:95003876-95003896 ( 6) TGACCTCA 1 chr6:34664734-34664754 ( 8) TGACCTCA 1 chr11:4116003-4116023 ( 1) TAACGTCA 1 chr10:113943521-11394354 ( 10) TGACGCAA 1 chr9:21832313-21832333 ( 8) TGATGTCA 1 chr17:4607436-4607456 ( 4) TGACGCAA 1 chr11:10562768-10562788 ( 9) TGACGCAA 1 chr1:936278-936298 ( 1) TGACGCAA 1 chr17:7465235-7465255 ( 2) TGACGTAC 1 chr5:167578233-167578253 ( 13) TCACGTAA 1 chr17:15903017-15903037 ( 1) TGACGTCG 1 chr17:17380285-17380305 ( 9) TGACGTGT 1 chr7:23145312-23145332 ( 9) TGACGTGT 1 chr8:17104377-17104397 ( 13) TGACGCGA 1 chr19:35225458-35225478 ( 3) AGACGCCA 1 chr16:88772871-88772891 ( 3) CGACGTCA 1 chr20:47044875-47044895 ( 9) TGACATCT 1 chr22:26879806-26879826 ( 9) TGACGTGC 1 chr3:45017732-45017752 ( 7) TGACGTGC 1 chr6:167528170-167528190 ( 5) ACACGTCA 1 chr6:27440232-27440252 ( 9) ATACGTCA 1 chr9:119702085-119702105 ( 3) ATACGTCA 1 chr18:2655163-2655183 ( 13) TGACGTTC 1 chr13:49822029-49822049 ( 11) AGGCGTCA 1 chr16:31128967-31128987 ( 1) TGGCGTCC 1 chrX:347710-347730 ( 7) TGTCATCA 1 chr1:20834645-20834665 ( 9) TGACGCAC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.84639 E= 1.0e-096 -99 -462 -1289 235 -380 -263 152 -273 231 -1289 -227 -273 -1289 160 -1289 -373 -221 -362 156 -1289 -1289 -117 -1289 229 -48 123 -200 -273 216 -182 -458 -115 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 76 E= 1.0e-096 0.092105 0.013158 0.000000 0.894737 0.013158 0.052632 0.907895 0.026316 0.907895 0.000000 0.065789 0.026316 0.000000 0.986842 0.000000 0.013158 0.039474 0.026316 0.934211 0.000000 0.000000 0.144737 0.000000 0.855263 0.131579 0.763158 0.078947 0.026316 0.815789 0.092105 0.013158 0.078947 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGACGTCA MEME-1 regular expression -------------------------------------------------------------------------------- TGACGTCA -------------------------------------------------------------------------------- Time 2.63 secs. ******************************************************************************** ******************************************************************************** MOTIF CGTCAYCR MEME-2 width = 8 sites = 19 llr = 147 E-value = 1.5e+000 ******************************************************************************** -------------------------------------------------------------------------------- Motif CGTCAYCR MEME-2 Description -------------------------------------------------------------------------------- Simplified A 12::a:35 pos.-specific C 9:1a:471 probability G :8:::::3 matrix T ::9::6:1 bits 2.5 * 2.3 * 2.0 * * 1.8 * * Relative 1.5 *** Entropy 1.3 ****** (11.2 bits) 1.0 ******* 0.8 ******* 0.5 ******** 0.3 ******** 0.0 -------- Multilevel CGTCATCA consensus CAG sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGTCAYCR MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr11:66112580-66112600 10 1.12e-05 TTCCGTGTG CGTCATCA GGA chr6:37400975-37400995 1 1.12e-05 . CGTCATCA GGCTGCGCTG chr9:135753693-135753713 10 1.12e-05 CGCCGACTG CGTCATCA GCA chr3:52444042-52444062 1 3.82e-05 . CGTCACCA AGGCGCGACG chr6:32908879-32908899 1 4.46e-05 . CATCATCA GTTACTAGGT chr14:23775957-23775977 10 4.46e-05 TCTGGGCCC CATCATCA CCC chr2:202507437-202507457 1 6.39e-05 . CGTCATCG GGCCGCGCCG chr6:15248975-15248995 3 7.56e-05 GA CGTCACAA AGGGACGGGC chr5:72861558-72861578 11 1.01e-04 TGCTCTGGTA CGTCATCT TC chr16:89126842-89126862 11 1.01e-04 CGTCTGCTCC CGTCATCT CA chr8:145747834-145747854 3 1.75e-04 CA CGTCATCC GCGCGCCCGC chr4:170533749-170533769 9 1.75e-04 GGCCGGCG CGTCACCG GCGC chr19:56015282-56015302 3 2.50e-04 GA CGTCACAG GCGCGCTGCG chr2:109335889-109335909 9 2.50e-04 CGCAAGTT CGTCACAG TGGT chr5:180611316-180611336 13 2.66e-04 AAACTGCACT CATCATAG chr6:27706260-27706280 2 2.87e-04 A CGCCATCA AGCTGCGCCC chr6:38607928-38607948 7 3.94e-04 AAGTCG AGTCACCA CACGTC chr7:99149742-99149762 10 4.29e-04 CCGGAAGTG CGTCACAC CCG chr3:44754120-44754140 11 5.05e-04 CTACCGGCCG CGCCACCA TT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGTCAYCR MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr11:66112580-66112600 1.1e-05 9_[+2]_3 chr6:37400975-37400995 1.1e-05 [+2]_12 chr9:135753693-135753713 1.1e-05 9_[+2]_3 chr3:52444042-52444062 3.8e-05 [+2]_12 chr6:32908879-32908899 4.5e-05 [+2]_12 chr14:23775957-23775977 4.5e-05 9_[+2]_3 chr2:202507437-202507457 6.4e-05 [+2]_12 chr6:15248975-15248995 7.6e-05 2_[+2]_10 chr5:72861558-72861578 0.0001 10_[+2]_2 chr16:89126842-89126862 0.0001 10_[+2]_2 chr8:145747834-145747854 0.00017 2_[+2]_10 chr4:170533749-170533769 0.00017 8_[+2]_4 chr19:56015282-56015302 0.00025 2_[+2]_10 chr2:109335889-109335909 0.00025 8_[+2]_4 chr5:180611316-180611336 0.00027 12_[+2] chr6:27706260-27706280 0.00029 1_[+2]_11 chr6:38607928-38607948 0.00039 6_[+2]_6 chr7:99149742-99149762 0.00043 9_[+2]_3 chr3:44754120-44754140 0.00051 10_[+2]_2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGTCAYCR MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CGTCAYCR width=8 seqs=19 chr11:66112580-66112600 ( 10) CGTCATCA 1 chr6:37400975-37400995 ( 1) CGTCATCA 1 chr9:135753693-135753713 ( 10) CGTCATCA 1 chr3:52444042-52444062 ( 1) CGTCACCA 1 chr6:32908879-32908899 ( 1) CATCATCA 1 chr14:23775957-23775977 ( 10) CATCATCA 1 chr2:202507437-202507457 ( 1) CGTCATCG 1 chr6:15248975-15248995 ( 3) CGTCACAA 1 chr5:72861558-72861578 ( 11) CGTCATCT 1 chr16:89126842-89126862 ( 11) CGTCATCT 1 chr8:145747834-145747854 ( 3) CGTCATCC 1 chr4:170533749-170533769 ( 9) CGTCACCG 1 chr19:56015282-56015302 ( 3) CGTCACAG 1 chr2:109335889-109335909 ( 9) CGTCACAG 1 chr5:180611316-180611336 ( 13) CATCATAG 1 chr6:27706260-27706280 ( 2) CGCCATCA 1 chr6:38607928-38607948 ( 7) AGTCACCA 1 chr7:99149742-99149762 ( 10) CGTCACAC 1 chr3:44754120-44754140 ( 11) CGCCACCA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGTCAYCR MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.31119 E= 1.5e+000 -180 154 -1089 -1089 -21 -1089 141 -1089 -1089 -163 -1089 235 -1089 162 -1089 -1089 245 -1089 -1089 -1089 -1089 37 -1089 172 52 118 -1089 -1089 152 -163 -27 -73 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGTCAYCR MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 19 E= 1.5e+000 0.052632 0.947368 0.000000 0.000000 0.157895 0.000000 0.842105 0.000000 0.000000 0.105263 0.000000 0.894737 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.421053 0.000000 0.578947 0.263158 0.736842 0.000000 0.000000 0.526316 0.105263 0.263158 0.105263 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CGTCAYCR MEME-2 regular expression -------------------------------------------------------------------------------- CGTCA[TC][CA][AG] -------------------------------------------------------------------------------- Time 3.46 secs. ******************************************************************************** ******************************************************************************** MOTIF RCGYGACG MEME-3 width = 8 sites = 15 llr = 122 E-value = 9.5e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif RCGYGACG MEME-3 Description -------------------------------------------------------------------------------- Simplified A 32:::a:: pos.-specific C :7:6::a: probability G 7:a:a::a matrix T :1:4:::: bits 2.5 * 2.3 * 2.0 * 1.8 * ** * Relative 1.5 * **** Entropy 1.3 * **** (11.7 bits) 1.0 * ****** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel GCGCGACG consensus AA T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCGYGACG MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr7:150924438-150924458 13 3.42e-05 TCGCGGGGCC GCGTGACG chr7:140624827-140624847 11 3.42e-05 TCACCCCGGT GCGTGACG TA chr4:57253663-57253683 12 5.39e-05 CCGCGTCGCT ACGTGACG T chr12:64616367-64616387 12 5.39e-05 CGTCATGCAA ACGTGACG T chr11:63706288-63706308 2 1.17e-04 G GCGCGACG CTCCTCCGCG chr19:36036462-36036482 9 1.17e-04 GTCACTGG GCGCGACG CCCC chr4:164088084-164088104 10 1.17e-04 ACGTATGTG GCGCGACG GCG chr3:52444042-52444062 11 1.17e-04 CGTCACCAAG GCGCGACG GC chr21:44527679-44527699 8 1.54e-04 CACCCGG ACGCGACG ACGCT chr15:50716555-50716575 5 1.54e-04 GGAG ACGCGACG CGTCGCCT chr3:130465680-130465700 13 1.84e-04 CGCCGAGCGG AAGTGACG chr20:33265047-33265067 11 2.20e-04 AGGCGGGCCG GAGCGACG GA chr16:20753140-20753160 13 2.20e-04 CGTCGGATAT GAGCGACG chr1:1510281-1510301 11 2.59e-04 CCGGCGCCTA GTGTGACG CG chr2:170440851-170440871 8 3.04e-04 GCTTCCG GTGCGACG CTGTC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCGYGACG MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:150924438-150924458 3.4e-05 12_[+3] chr7:140624827-140624847 3.4e-05 10_[+3]_2 chr4:57253663-57253683 5.4e-05 11_[+3]_1 chr12:64616367-64616387 5.4e-05 11_[+3]_1 chr11:63706288-63706308 0.00012 1_[+3]_11 chr19:36036462-36036482 0.00012 8_[+3]_4 chr4:164088084-164088104 0.00012 9_[+3]_3 chr3:52444042-52444062 0.00012 10_[+3]_2 chr21:44527679-44527699 0.00015 7_[+3]_5 chr15:50716555-50716575 0.00015 4_[+3]_8 chr3:130465680-130465700 0.00018 12_[+3] chr20:33265047-33265067 0.00022 10_[+3]_2 chr16:20753140-20753160 0.00022 12_[+3] chr1:1510281-1510301 0.00026 10_[+3]_2 chr2:170440851-170440871 0.0003 7_[+3]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCGYGACG MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF RCGYGACG width=8 seqs=15 chr7:150924438-150924458 ( 13) GCGTGACG 1 chr7:140624827-140624847 ( 11) GCGTGACG 1 chr4:57253663-57253683 ( 12) ACGTGACG 1 chr12:64616367-64616387 ( 12) ACGTGACG 1 chr11:63706288-63706308 ( 2) GCGCGACG 1 chr19:36036462-36036482 ( 9) GCGCGACG 1 chr4:164088084-164088104 ( 10) GCGCGACG 1 chr3:52444042-52444062 ( 11) GCGCGACG 1 chr21:44527679-44527699 ( 8) ACGCGACG 1 chr15:50716555-50716575 ( 5) ACGCGACG 1 chr3:130465680-130465700 ( 13) AAGTGACG 1 chr20:33265047-33265067 ( 11) GAGCGACG 1 chr16:20753140-20753160 ( 13) GAGCGACG 1 chr1:1510281-1510301 ( 11) GTGTGACG 1 chr2:170440851-170440871 ( 8) GTGCGACG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCGYGACG MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.67734 E= 9.5e+001 86 -1055 107 -1055 13 104 -1055 -39 -1055 -1055 166 -1055 -1055 88 -1055 119 -1055 -1055 166 -1055 245 -1055 -1055 -1055 -1055 162 -1055 -1055 -1055 -1055 166 -1055 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCGYGACG MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 15 E= 9.5e+001 0.333333 0.000000 0.666667 0.000000 0.200000 0.666667 0.000000 0.133333 0.000000 0.000000 1.000000 0.000000 0.000000 0.600000 0.000000 0.400000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif RCGYGACG MEME-3 regular expression -------------------------------------------------------------------------------- [GA][CA]G[CT]GACG -------------------------------------------------------------------------------- Time 4.17 secs. ******************************************************************************** ******************************************************************************** MOTIF ACATATTA MEME-4 width = 8 sites = 2 llr = 26 E-value = 5.4e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif ACATATTA MEME-4 Description -------------------------------------------------------------------------------- Simplified A a:a:a::a pos.-specific C :a:::::: probability G :::::::: matrix T :::a:aa: bits 2.5 * ****** 2.3 * ****** 2.0 * ****** 1.8 * ****** Relative 1.5 ******** Entropy 1.3 ******** (19.0 bits) 1.0 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel ACATATTA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACATATTA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr9:71394884-71394904 5 1.95e-06 GCGC ACATATTA CGCATTAA chr3:51534013-51534033 10 1.95e-06 CAGCGGCCC ACATATTA TGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACATATTA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr9:71394884-71394904 2e-06 4_[+4]_8 chr3:51534013-51534033 2e-06 9_[+4]_3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACATATTA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ACATATTA width=8 seqs=2 chr9:71394884-71394904 ( 5) ACATATTA 1 chr3:51534013-51534033 ( 10) ACATATTA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACATATTA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.6653 E= 5.4e+002 244 -765 -765 -765 -765 162 -765 -765 244 -765 -765 -765 -765 -765 -765 251 244 -765 -765 -765 -765 -765 -765 251 -765 -765 -765 251 244 -765 -765 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACATATTA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 5.4e+002 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 1.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ACATATTA MEME-4 regular expression -------------------------------------------------------------------------------- ACATATTA -------------------------------------------------------------------------------- Time 4.91 secs. ******************************************************************************** ******************************************************************************** MOTIF TATTGYTT MEME-5 width = 8 sites = 2 llr = 25 E-value = 7.0e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif TATTGYTT MEME-5 Description -------------------------------------------------------------------------------- Simplified A :a:::::: pos.-specific C :::::5:: probability G ::::a::: matrix T a:aa:5aa bits 2.5 **** ** 2.3 **** ** 2.0 **** ** 1.8 ***** ** Relative 1.5 ***** ** Entropy 1.3 ***** ** (17.7 bits) 1.0 ******** 0.8 ******** 0.5 ******** 0.3 ******** 0.0 -------- Multilevel TATTGCTT consensus T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TATTGYTT MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr18:46458711-46458731 2 1.67e-06 T TATTGTTT TTGTTCCTGT chr1:90593036-90593056 8 4.76e-06 TATGAGG TATTGCTT TCATT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TATTGYTT MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr18:46458711-46458731 1.7e-06 1_[+5]_11 chr1:90593036-90593056 4.8e-06 7_[+5]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TATTGYTT MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TATTGYTT width=8 seqs=2 chr18:46458711-46458731 ( 2) TATTGTTT 1 chr1:90593036-90593056 ( 8) TATTGCTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TATTGYTT MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 10.6653 E= 7.0e+002 -765 -765 -765 251 244 -765 -765 -765 -765 -765 -765 251 -765 -765 -765 251 -765 -765 165 -765 -765 62 -765 151 -765 -765 -765 251 -765 -765 -765 251 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TATTGYTT MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 7.0e+002 0.000000 0.000000 0.000000 1.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.500000 0.000000 0.500000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TATTGYTT MEME-5 regular expression -------------------------------------------------------------------------------- TATTG[CT]TT -------------------------------------------------------------------------------- Time 5.61 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:9649317-9649337 5.84e-01 20 chr7:93633684-93633704 6.56e-05 11_[+2(3.82e-05)]_1 chr11:67374370-67374390 5.71e-06 [+3(3.42e-05)]_12 chr1:32110257-32110277 6.97e-03 8_[+1(4.94e-05)]_4 chr6:139456096-139456116 8.31e-01 20 chr3:52444042-52444062 2.65e-04 [+2(3.82e-05)]_12 chr13:49822029-49822049 3.43e-02 20 chr1:243265068-243265088 7.48e-01 20 chr3:44771086-44771106 8.43e-05 7_[+1(1.09e-05)]_5 chr1:47644914-47644934 7.09e-01 20 chrX:102024048-102024068 1.82e-08 5_[+1(1.09e-05)]_7 chr11:77185429-77185449 6.33e-01 20 chr14:23775957-23775977 3.37e-02 9_[+2(4.46e-05)]_3 chr4:110736651-110736671 7.04e-01 20 chr2:110962604-110962624 6.72e-05 5_[+1(6.96e-05)]_7 chr16:86588812-86588832 8.20e-01 20 chr9:33076669-33076689 5.77e-01 20 chr9:111696391-111696411 6.83e-01 20 chr14:55738836-55738856 2.17e-03 12_[+1(1.09e-05)] chr14:36278581-36278601 4.33e-02 20 chr8:37605571-37605591 5.62e-05 5_[+1(1.09e-05)]_7 chr6:34664734-34664754 2.15e-03 20 chr2:28114140-28114160 6.83e-01 20 chr8:95003876-95003896 2.80e-04 20 chr18:2571465-2571485 9.45e-01 20 chr9:134955299-134955319 3.28e-01 20 chr1:154600465-154600485 2.13e-04 [+1(7.59e-05)]_12 chr19:50979544-50979564 3.44e-01 20 chr8:144623647-144623667 9.09e-01 20 chr16:48644198-48644218 1.50e-04 9_[+1(1.09e-05)]_3 chr5:95297759-95297779 3.49e-02 20 chr14:100150240-10015026 9.81e-02 20 chr7:75795900-75795920 3.27e-03 20 chr2:74781573-74781593 2.99e-06 5_[+1(1.09e-05)]_7 chr6:126661245-126661265 7.06e-01 20 chrX:102809889-102809909 1.54e-01 20 chr7:140624827-140624847 2.25e-02 10_[+3(3.42e-05)]_2 chr14:24769033-24769053 1.84e-01 20 chr3:185000683-185000703 9.87e-01 20 chr4:119512855-119512875 3.79e-06 9_[+1(1.09e-05)]_3 chr11:33369216-33369236 5.98e-02 20 chr19:57862613-57862633 3.72e-02 20 chr1:228296997-228297017 8.54e-01 20 chr15:42841000-42841020 8.21e-01 20 chr19:36103621-36103641 7.57e-05 8_[+1(1.09e-05)]_4 chr3:130465680-130465700 2.19e-01 20 chr6:27706260-27706280 9.83e-02 20 chr7:45808672-45808692 4.13e-02 20 chr4:123073438-123073458 4.96e-01 20 chr2:19548195-19548215 1.83e-01 20 chr7:66309968-66309988 1.05e-04 6_[+1(1.09e-05)]_6 chr20:47044875-47044895 3.38e-03 20 chr22:36761209-36761229 5.21e-02 20 chr7:150924438-150924458 4.60e-02 12_[+3(3.42e-05)] chr12:64616367-64616387 6.58e-04 11_[+3(5.39e-05)]_1 chr1:1510281-1510301 1.44e-02 20 chr2:3605935-3605955 5.54e-01 20 chr2:190305806-190305826 6.46e-01 20 chr1:936278-936298 1.38e-01 20 chr13:45915376-45915396 8.42e-01 20 chr3:184053658-184053678 5.32e-01 20 chr2:96068439-96068459 5.63e-01 20 chr6:38607928-38607948 4.85e-02 20 chrX:48980222-48980242 5.33e-01 20 chr4:39367988-39368008 3.78e-03 9_[+1(1.09e-05)]_3 chr7:65958573-65958593 9.74e-01 20 chr19:50862239-50862259 2.67e-04 20 chr6:15248975-15248995 6.53e-03 2_[+2(7.56e-05)]_10 chr7:5553438-5553458 8.99e-01 20 chr8:92082270-92082290 1.74e-02 20 chr5:137673200-137673220 7.43e-02 20 chr18:2655163-2655183 7.56e-02 20 chr6:43027172-43027192 5.10e-01 20 chr4:103940857-103940877 5.95e-01 20 chr15:50716555-50716575 2.97e-03 20 chr16:58283851-58283871 4.69e-01 20 chr14:36789873-36789893 2.53e-03 9_[+1(1.70e-05)]_3 chr22:19159172-19159192 3.03e-03 1_[+1(6.96e-05)]_11 chr5:70751415-70751435 9.33e-01 20 chr2:130939149-130939169 3.74e-01 20 chrX:48659828-48659848 8.81e-01 20 chr12:76953506-76953526 2.04e-02 20 chr11:72433629-72433649 8.70e-02 20 chr3:45017732-45017752 2.41e-02 20 chr17:38083891-38083911 1.17e-01 20 chr16:81348506-81348526 8.10e-02 20 chr22:42078501-42078521 1.24e-01 20 chr6:109416644-109416664 2.74e-01 20 chr4:8430235-8430255 2.27e-05 3_[+1(1.09e-05)]_9 chr11:10562768-10562788 1.64e-02 20 chr1:156698671-156698691 4.23e-01 20 chr5:36151276-36151296 5.32e-01 20 chr1:224180345-224180365 2.75e-04 [+1(1.09e-05)]_12 chr16:20753140-20753160 1.77e-02 20 chr3:185304054-185304074 8.60e-01 20 chr7:23145312-23145332 1.39e-03 20 chr15:41047459-41047479 4.09e-01 20 chr16:67927143-67927163 2.31e-03 9_[+1(6.96e-05)]_3 chr3:112280049-112280069 1.20e-01 20 chr1:714058-714078 8.60e-05 9_[+1(1.09e-05)]_3 chr2:109335889-109335909 6.47e-02 20 chr19:47987500-47987520 9.85e-01 20 chr14:23388136-23388156 7.13e-01 20 chr1:32671243-32671263 5.72e-01 20 chr17:8152593-8152613 1.80e-04 4_[+1(1.70e-05)]_8 chr7:102036799-102036819 1.01e-04 20 chr7:107204373-107204393 9.84e-01 20 chr16:71879838-71879858 3.47e-01 20 chr2:27712622-27712642 4.36e-01 20 chr14:32030594-32030614 5.23e-02 20 chr4:170533749-170533769 4.94e-02 20 chr5:173043752-173043772 9.67e-01 20 chr17:4607436-4607456 5.38e-02 20 chr2:39005321-39005341 3.45e-01 20 chr21:44527679-44527699 1.10e-01 20 chr5:78810426-78810446 6.67e-04 20 chr3:154042335-154042355 6.31e-01 20 chr4:164088084-164088104 3.08e-03 20 chr20:3801433-3801453 3.22e-01 20 chr9:135753693-135753713 2.87e-03 9_[+2(1.12e-05)]_3 chr13:111805958-11180597 9.63e-01 20 chr7:73097899-73097919 7.24e-01 20 chr12:58138389-58138409 9.81e-05 12_[+2(6.39e-05)] chr8:66754804-66754824 1.38e-03 1_[+1(1.09e-05)]_11 chr19:35225458-35225478 1.52e-02 20 chr2:65547666-65547686 3.34e-01 20 chr2:68290163-68290183 2.17e-01 20 chr5:180688142-180688162 2.79e-03 8_[+1(4.94e-05)]_4 chr8:145747834-145747854 3.61e-02 20 chr3:51534013-51534033 5.17e-04 9_[+4(1.95e-06)]_3 chr9:125027115-125027135 6.64e-01 20 chr9:119702085-119702105 4.02e-03 20 chr1:2344012-2344032 1.50e-01 20 chr5:1345287-1345307 1.58e-04 20 chr16:89126842-89126862 7.63e-03 20 chr20:42286159-42286179 3.42e-03 7_[+1(1.09e-05)]_5 chr7:56019561-56019581 5.80e-03 1_[+1(6.96e-05)]_11 chr17:17380285-17380305 2.48e-02 20 chr19:9546227-9546247 5.59e-01 20 chr9:86323116-86323136 7.06e-01 20 chr1:212662055-212662075 2.65e-01 20 chr5:140098481-140098501 5.42e-02 20 chr15:63481618-63481638 9.99e-01 20 chr1:70820711-70820731 2.62e-01 20 chr1:90593036-90593056 8.84e-04 7_[+5(4.76e-06)]_5 chr17:7465235-7465255 3.57e-03 20 chr5:134074118-134074138 4.64e-01 20 chr16:70333066-70333086 2.40e-01 20 chr6:37400975-37400995 7.87e-03 [+2(1.12e-05)]_12 chr5:180611316-180611336 2.15e-02 20 chr7:19748676-19748696 5.00e-01 20 chr17:27071420-27071440 6.57e-03 [+1(1.09e-05)]_12 chr7:124569905-124569925 6.44e-01 20 chr6:13429782-13429802 2.17e-01 20 chr22:50946637-50946657 4.03e-01 20 chr1:228291043-228291063 2.07e-03 2_[+1(1.09e-05)]_10 chr9:21832313-21832333 9.98e-03 20 chr16:67694773-67694793 9.27e-01 20 chr9:71394884-71394904 1.52e-04 4_[+4(1.95e-06)]_8 chr4:120375866-120375886 7.59e-01 20 chr8:17104377-17104397 6.90e-02 20 chr3:10028534-10028554 1.60e-04 4_[+1(1.09e-05)]_8 chr19:36036462-36036482 3.68e-02 20 chr7:44646090-44646110 1.09e-04 9_[+1(1.09e-05)]_3 chr10:102027427-10202744 6.60e-03 10_[+1(4.94e-05)]_2 chr4:57253663-57253683 1.02e-02 11_[+3(5.39e-05)]_1 chr4:122745103-122745123 4.43e-04 8_[+1(1.09e-05)]_4 chr18:158536-158556 4.27e-01 20 chr13:45563638-45563658 6.50e-01 20 chr9:6015639-6015659 9.46e-01 20 chr14:88851974-88851994 1.14e-06 6_[+1(1.09e-05)]_6 chr10:113943521-11394354 2.24e-02 20 chr3:44754120-44754140 8.08e-02 20 chr2:135676181-135676201 4.16e-01 20 chr1:20834645-20834665 3.12e-02 20 chr17:15903017-15903037 1.35e-01 20 chr17:79093600-79093620 8.99e-01 20 chrX:47518545-47518565 9.52e-01 20 chr1:1655795-1655815 4.20e-01 20 chr3:101280643-101280663 4.04e-04 3_[+1(1.70e-05)]_9 chr2:202507437-202507457 3.34e-02 [+2(6.39e-05)]_12 chr2:220110180-220110200 3.48e-01 20 chr5:167578233-167578253 6.38e-04 20 chr9:138853281-138853301 5.39e-01 20 chr1:22379155-22379175 4.64e-03 1_[+1(1.09e-05)]_11 chr2:101010820-101010840 5.65e-01 20 chr6:53213810-53213830 8.37e-01 20 chr8:21967216-21967236 6.18e-01 20 chr1:40626953-40626973 9.93e-01 20 chr17:4046959-4046979 1.92e-04 6_[+1(1.09e-05)]_6 chrX:118699367-118699387 1.34e-04 4_[+1(1.09e-05)]_8 chr7:99149742-99149762 1.46e-02 20 chr17:33914270-33914290 6.57e-04 7_[+1(1.09e-05)]_5 chr6:32908879-32908899 2.06e-03 [+2(4.46e-05)]_12 chr5:86708756-86708776 6.97e-01 20 chr10:124740139-12474015 3.26e-01 20 chr6:41888891-41888911 3.53e-01 20 chr12:110011036-11001105 5.15e-05 3_[+1(4.94e-05)]_9 chr16:31128967-31128987 8.02e-02 20 chr19:18215343-18215363 9.96e-01 20 chr19:11616674-11616694 2.03e-01 20 chr11:66112580-66112600 4.04e-03 9_[+2(1.12e-05)]_3 chr5:72861558-72861578 4.72e-03 20 chr11:64889650-64889670 6.42e-02 20 chr3:48488080-48488100 1.75e-01 20 chr1:1447429-1447449 3.08e-01 20 chr14:71067376-71067396 1.16e-01 20 chr2:170440851-170440871 1.81e-01 20 chr15:40861503-40861523 9.58e-01 20 chr17:42264273-42264293 4.41e-02 20 chr1:153395132-153395152 2.59e-01 20 chr6:27440232-27440252 2.24e-03 20 chrX:347710-347730 1.54e-02 20 chr20:18268851-18268871 9.90e-01 20 chr7:99097926-99097946 3.98e-01 20 chr16:87799588-87799608 1.46e-01 20 chr4:148605364-148605384 2.88e-01 20 chr6:167528170-167528190 5.93e-04 20 chr22:26879806-26879826 4.13e-02 20 chr14:105219451-10521947 9.70e-01 20 chr19:55987878-55987898 7.91e-01 20 chr9:27573825-27573845 5.09e-01 20 chr5:150080654-150080674 2.98e-01 20 chr8:10697394-10697414 2.92e-03 5_[+1(1.09e-05)]_7 chr20:23338769-23338789 7.18e-01 20 chr12:133656798-13365681 1.16e-01 20 chr3:142166869-142166889 4.79e-01 20 chr4:54232239-54232259 6.59e-01 20 chrX:24711897-24711917 5.48e-01 20 chr5:139042447-139042467 2.66e-01 20 chr14:61447813-61447833 8.99e-01 20 chr19:56015282-56015302 3.15e-02 20 chr11:4116003-4116023 1.17e-02 20 chr1:89149913-89149933 5.96e-01 20 chr8:146277855-146277875 9.37e-01 20 chr3:196594756-196594776 8.70e-01 20 chr19:16683315-16683335 1.23e-01 20 chrX:48334527-48334547 8.21e-01 20 chr20:33265047-33265067 2.49e-01 20 chr11:63706288-63706308 7.60e-02 20 chr10:111971062-11197108 2.97e-04 10_[+1(1.09e-05)]_2 chr3:25706526-25706546 7.49e-01 20 chr22:47158446-47158466 5.50e-01 20 chr19:56028467-56028487 1.76e-03 5_[+1(4.94e-05)]_7 chr9:139760875-139760895 1.96e-01 20 chr3:156544035-156544055 9.25e-01 20 chr16:88772871-88772891 1.49e-03 5_[+2(6.39e-05)]_7 chr2:132250624-132250644 4.49e-01 20 chr18:46458711-46458731 6.42e-03 1_[+5(1.67e-06)]_11 chr7:156685981-156686001 8.83e-01 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n05.farnam.hpc.yale.internal ********************************************************************************