******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/BCL3.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr7:55504346-55504366 1.0000 20 chr16:87097310-87097330 1.0000 20 chr16:87530293-87530313 1.0000 20 chr7:101961440-101961460 1.0000 20 chr17:38220624-38220644 1.0000 20 chr18:11861837-11861857 1.0000 20 chr19:19185511-19185531 1.0000 20 chr11:65810662-65810682 1.0000 20 chr1:11894141-11894161 1.0000 20 chr15:93586482-93586502 1.0000 20 chr5:6687786-6687806 1.0000 20 chr5:142630928-142630948 1.0000 20 chr20:56468847-56468867 1.0000 20 chr22:46338827-46338847 1.0000 20 chr2:220330593-220330613 1.0000 20 chr7:154900403-154900423 1.0000 20 chr15:78088597-78088617 1.0000 20 chr9:130348495-130348515 1.0000 20 chr17:4415996-4416016 1.0000 20 chr1:25912995-25913015 1.0000 20 chr3:50305909-50305929 1.0000 20 chr17:72182745-72182765 1.0000 20 chr3:126262523-126262543 1.0000 20 chr19:7252566-7252586 1.0000 20 chr15:75952905-75952925 1.0000 20 chr13:21596391-21596411 1.0000 20 chr1:2303672-2303692 1.0000 20 chr6:37602204-37602224 1.0000 20 chr10:21503460-21503480 1.0000 20 chr5:10538378-10538398 1.0000 20 chr8:143381036-143381056 1.0000 20 chr16:4740577-4740597 1.0000 20 chr2:27342078-27342098 1.0000 20 chr7:154415306-154415326 1.0000 20 chr8:10427804-10427824 1.0000 20 chr19:46171033-46171053 1.0000 20 chr17:19649990-19650010 1.0000 20 chr17:72541449-72541469 1.0000 20 chr19:47947887-47947907 1.0000 20 chr19:4543063-4543083 1.0000 20 chr12:804457-804477 1.0000 20 chr16:86107897-86107917 1.0000 20 chr5:148772545-148772565 1.0000 20 chr3:16246436-16246456 1.0000 20 chr5:172179316-172179336 1.0000 20 chr11:68118438-68118458 1.0000 20 chr9:36843062-36843082 1.0000 20 chr19:48616676-48616696 1.0000 20 chr13:111288725-11128874 1.0000 20 chr2:65253963-65253983 1.0000 20 chr21:46529148-46529168 1.0000 20 chr1:25190744-25190764 1.0000 20 chr3:9556179-9556199 1.0000 20 chr12:125000206-12500022 1.0000 20 chr16:30907092-30907112 1.0000 20 chr14:35832204-35832224 1.0000 20 chr15:57612491-57612511 1.0000 20 chr21:46408362-46408382 1.0000 20 chrX:73765908-73765928 1.0000 20 chr17:77995679-77995699 1.0000 20 chr17:79943001-79943021 1.0000 20 chr9:138899340-138899360 1.0000 20 chr20:23425673-23425693 1.0000 20 chr12:125023764-12502378 1.0000 20 chr2:241440627-241440647 1.0000 20 chr1:3608549-3608569 1.0000 20 chr10:127817383-12781740 1.0000 20 chr14:105223011-10522303 1.0000 20 chr1:1165306-1165326 1.0000 20 chr2:112918273-112918293 1.0000 20 chrX:152705588-152705608 1.0000 20 chr19:1642250-1642270 1.0000 20 chr21:43488844-43488864 1.0000 20 chr1:226837196-226837216 1.0000 20 chr17:35013884-35013904 1.0000 20 chr17:982443-982463 1.0000 20 chr6:29949272-29949292 1.0000 20 chr4:8375162-8375182 1.0000 20 chr20:61967881-61967901 1.0000 20 chr19:1417282-1417302 1.0000 20 chr1:55545515-55545535 1.0000 20 chr1:40421413-40421433 1.0000 20 chr4:1331196-1331216 1.0000 20 chr17:78264186-78264206 1.0000 20 chr19:39648800-39648820 1.0000 20 chr19:3831018-3831038 1.0000 20 chr8:81871503-81871523 1.0000 20 chr19:46461821-46461841 1.0000 20 chr10:23437301-23437321 1.0000 20 chr9:34652379-34652399 1.0000 20 chr12:124338404-12433842 1.0000 20 chr19:7972259-7972279 1.0000 20 chr16:70974041-70974061 1.0000 20 chr20:44845893-44845913 1.0000 20 chr10:134807189-13480720 1.0000 20 chr19:28565866-28565886 1.0000 20 chr17:35174387-35174407 1.0000 20 chr16:31343249-31343269 1.0000 20 chr5:149643046-149643066 1.0000 20 chr12:1925990-1926010 1.0000 20 chr15:41206410-41206430 1.0000 20 chr8:130564397-130564417 1.0000 20 chr17:65050991-65051011 1.0000 20 chr17:3593174-3593194 1.0000 20 chr11:2310186-2310206 1.0000 20 chr20:56371365-56371385 1.0000 20 chr3:54751760-54751780 1.0000 20 chr17:62077162-62077182 1.0000 20 chr2:3467936-3467956 1.0000 20 chr19:47140582-47140602 1.0000 20 chr17:74273775-74273795 1.0000 20 chr13:111107980-11110800 1.0000 20 chr17:21247819-21247839 1.0000 20 chr11:47377416-47377436 1.0000 20 chr2:240212363-240212383 1.0000 20 chr21:43339263-43339283 1.0000 20 chr9:96411998-96412018 1.0000 20 chr5:1502024-1502044 1.0000 20 chr18:13590056-13590076 1.0000 20 chr18:28565913-28565933 1.0000 20 chr9:127155209-127155229 1.0000 20 chr19:1389203-1389223 1.0000 20 chr13:113773888-11377390 1.0000 20 chr2:127801345-127801365 1.0000 20 chr17:80005323-80005343 1.0000 20 chr16:57985298-57985318 1.0000 20 chr22:25779996-25780016 1.0000 20 chr16:88959743-88959763 1.0000 20 chr12:22174321-22174341 1.0000 20 chr1:25297620-25297640 1.0000 20 chr10:134775407-13477542 1.0000 20 chr13:100555643-10055566 1.0000 20 chr12:54944138-54944158 1.0000 20 chr19:3808160-3808180 1.0000 20 chr2:240428879-240428899 1.0000 20 chr14:99850179-99850199 1.0000 20 chr1:228122717-228122737 1.0000 20 chr19:19097906-19097926 1.0000 20 chr2:241288762-241288782 1.0000 20 chr11:123421128-12342114 1.0000 20 chr1:30216290-30216310 1.0000 20 chr12:125161493-12516151 1.0000 20 chr16:25645045-25645065 1.0000 20 chr17:79122590-79122610 1.0000 20 chr13:114497782-11449780 1.0000 20 chr9:34653237-34653257 1.0000 20 chr12:114290710-11429073 1.0000 20 chr3:195614751-195614771 1.0000 20 chr2:765526-765546 1.0000 20 chr10:99685481-99685501 1.0000 20 chr12:124818497-12481851 1.0000 20 chr12:9514798-9514818 1.0000 20 chr12:10696302-10696322 1.0000 20 chr1:2280269-2280289 1.0000 20 chr7:155137374-155137394 1.0000 20 chr11:68616091-68616111 1.0000 20 chr5:152860164-152860184 1.0000 20 chr17:78198077-78198097 1.0000 20 chr16:29679266-29679286 1.0000 20 chr6:166121131-166121151 1.0000 20 chr19:42409629-42409649 1.0000 20 chr2:26784872-26784892 1.0000 20 chr22:44542108-44542128 1.0000 20 chr8:144636691-144636711 1.0000 20 chr6:37537282-37537302 1.0000 20 chr5:14438517-14438537 1.0000 20 chr8:29949364-29949384 1.0000 20 chr18:77943738-77943758 1.0000 20 chr14:61906298-61906318 1.0000 20 chr17:7013056-7013076 1.0000 20 chr14:77624850-77624870 1.0000 20 chr18:77557592-77557612 1.0000 20 chr12:131148945-13114896 1.0000 20 chr22:36029736-36029756 1.0000 20 chr20:61168318-61168338 1.0000 20 chr6:28105524-28105544 1.0000 20 chr8:134820664-134820684 1.0000 20 chr11:65577990-65578010 1.0000 20 chr21:46730071-46730091 1.0000 20 chr7:98674458-98674478 1.0000 20 chr10:1568002-1568022 1.0000 20 chr13:46698793-46698813 1.0000 20 chr12:48338646-48338666 1.0000 20 chr3:98332049-98332069 1.0000 20 chr2:9606474-9606494 1.0000 20 chr11:78777735-78777755 1.0000 20 chr17:76694221-76694241 1.0000 20 chr12:24872562-24872582 1.0000 20 chr1:3563397-3563417 1.0000 20 chr8:58162275-58162295 1.0000 20 chr5:171651109-171651129 1.0000 20 chr17:79131166-79131186 1.0000 20 chr16:1777295-1777315 1.0000 20 chr8:142244187-142244207 1.0000 20 chr2:235209765-235209785 1.0000 20 chr9:129946683-129946703 1.0000 20 chr10:14013137-14013157 1.0000 20 chr17:80681438-80681458 1.0000 20 chr22:29607626-29607646 1.0000 20 chr9:88861866-88861886 1.0000 20 chr8:52307625-52307645 1.0000 20 chr15:79744728-79744748 1.0000 20 chr14:35822280-35822300 1.0000 20 chr14:54349507-54349527 1.0000 20 chr22:39157920-39157940 1.0000 20 chr17:75800029-75800049 1.0000 20 chr16:28050983-28051003 1.0000 20 chr17:75869181-75869201 1.0000 20 chr12:120683064-12068308 1.0000 20 chr1:23039058-23039078 1.0000 20 chr11:61301909-61301929 1.0000 20 chr19:35888147-35888167 1.0000 20 chr6:97345778-97345798 1.0000 20 chr2:241165275-241165295 1.0000 20 chr1:22896788-22896808 1.0000 20 chr8:6604172-6604192 1.0000 20 chr10:1148102-1148122 1.0000 20 chr3:189815007-189815027 1.0000 20 chr11:123121879-12312189 1.0000 20 chr4:146444442-146444462 1.0000 20 chr7:129950054-129950074 1.0000 20 chr17:62932453-62932473 1.0000 20 chr20:62478602-62478622 1.0000 20 chr15:67225088-67225108 1.0000 20 chr14:99787812-99787832 1.0000 20 chr17:81028883-81028903 1.0000 20 chr12:3215012-3215032 1.0000 20 chr12:66466567-66466587 1.0000 20 chr4:186228436-186228456 1.0000 20 chr10:3441725-3441745 1.0000 20 chr4:38787784-38787804 1.0000 20 chr2:121035620-121035640 1.0000 20 chr7:151587269-151587289 1.0000 20 chr1:42611896-42611916 1.0000 20 chr17:78913161-78913181 1.0000 20 chr17:16311551-16311571 1.0000 20 chr14:105058844-10505886 1.0000 20 chr2:10156280-10156300 1.0000 20 chrX:148280958-148280978 1.0000 20 chr8:135585074-135585094 1.0000 20 chr9:132754501-132754521 1.0000 20 chr6:24933688-24933708 1.0000 20 chr11:64463175-64463195 1.0000 20 chr9:136657609-136657629 1.0000 20 chr19:35909174-35909194 1.0000 20 chr21:43813476-43813496 1.0000 20 chr8:135612653-135612673 1.0000 20 chr3:99137170-99137190 1.0000 20 chr19:39820055-39820075 1.0000 20 chr3:4796157-4796177 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_BCL3/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/BCL3.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.233 C 0.261 G 0.268 T 0.237 Background letter frequencies (from file dataset with add-one prior applied): A 0.233 C 0.261 G 0.268 T 0.237 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TGTGTGTG MEME-1 width = 8 sites = 98 llr = 775 E-value = 2.8e-135 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-1 Description -------------------------------------------------------------------------------- Simplified A :::22:11 pos.-specific C ::3:::1: probability G :a:8:a:9 matrix T 9:7:8:9: bits 2.1 1.9 1.7 ** * 1.5 ** **** Relative 1.3 ** **** Entropy 1.0 ******** (11.4 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TGTGTGTG consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr11:123121879-12312189 9 1.63e-05 ggtgtgca tgtgtgtg tttg chr22:39157920-39157940 8 1.63e-05 gtgaatg tgtgtgtg cgagt chr22:29607626-29607646 8 1.63e-05 gtgtgca tgtgtgtg cgtgc chr17:80681438-80681458 4 1.63e-05 gta tgtgtgtg catgtgtgt chr7:98674458-98674478 7 1.63e-05 tgtgta tgtgtgtg cacgtg chr8:134820664-134820684 4 1.63e-05 aca tgtgtgtg catgcctgt chr22:36029736-36029756 5 1.63e-05 tcag tgtgtgtg cgtgtgtg chr18:77557592-77557612 4 1.63e-05 cga tgtgtgtg cacctgtgt chr6:37537282-37537302 8 1.63e-05 gcatgaa tgtgtgtg agtca chr19:42409629-42409649 5 1.63e-05 atgg tgtgtgtg tatgcata chr16:29679266-29679286 2 1.63e-05 c tgtgtgtg tatgtgtgca chr12:124818497-12481851 6 1.63e-05 acgtg tgtgtgtg cgggtgc chr13:114497782-11449780 7 1.63e-05 TGCACA TGTGTGTG CGTGTG chr19:3808160-3808180 2 1.63e-05 a tgtgtgtg cctgtgcgtg chr12:54944138-54944158 13 1.63e-05 CCACATGACA TGTGTGTG chr18:28565913-28565933 6 1.63e-05 gtgcg tgtgtgtg cgcatct chr18:13590056-13590076 9 1.63e-05 tgactgca tgtgtgtg ggtg chr21:43339263-43339283 13 1.63e-05 tgtatgagca tgtgtgtg chr20:56371365-56371385 10 1.63e-05 ttgtattta tgtgtgtg tgA chr17:35174387-35174407 7 1.63e-05 cgtgtg tgtgtgtg catgtg chr1:3608549-3608569 5 1.63e-05 tgca tgtgtgtg tctaagcg chr21:46408362-46408382 13 1.63e-05 catgtgtgca tgtgtgtg chr1:25190744-25190764 12 1.63e-05 cgtgtctgca tgtgtgtg c chr21:46529148-46529168 3 1.63e-05 ta tgtgtgtg cgcgcgtgtg chr9:36843062-36843082 6 1.63e-05 gagcg tgtgtgtg cctgtgt chr5:172179316-172179336 12 1.63e-05 tgtgagcgtg tgtgtgtg t chr5:148772545-148772565 9 1.63e-05 tgtgtgcg tgtgtgtg ctgc chr17:19649990-19650010 11 1.63e-05 catgtgcgtg tgtgtgtg cg chr17:72182745-72182765 12 1.63e-05 tgtgtgtgca tgtgtgtg c chr3:50305909-50305929 11 1.63e-05 CAGTGCCACA TGTGTGTG ca chr1:25912995-25913015 9 1.63e-05 tgcacatg tgtgtgtg ccta chr9:130348495-130348515 11 1.63e-05 tgcgtgtgct tgtgtgtg cg chr1:11894141-11894161 11 1.63e-05 tgtgtatgca tgtgtgtg cg chr19:19185511-19185531 4 1.63e-05 gtg tgtgtgtg cgtgcgtgt chr10:3441725-3441745 4 3.42e-05 tga tgcgtgtg cacgcgcgt chr17:62077162-62077182 4 3.42e-05 acg tgcgtgtg caagggtgt chr10:23437301-23437321 13 3.42e-05 tgcgtgtgcg tgcgtgtg chr20:61967881-61967901 7 3.42e-05 cgtatc tgcgtgtg tgcgtg chr12:804457-804477 8 3.42e-05 atgtgca tgcgtgtg cgtgc chr13:21596391-21596411 9 3.42e-05 tgcatatg tgcgtgtg catg chr2:220330593-220330613 7 3.42e-05 tgtgcg tgcgtgtg catgtg chr7:55504346-55504366 4 3.42e-05 gtg tgcgtgtg tgcgtgcgt chr12:125161493-12516151 8 4.83e-05 gcgggca tgtatgtg cgtgt chr1:25297620-25297640 2 4.83e-05 a tgtatgtg tgcatgtgtg chr16:1777295-1777315 7 6.43e-05 cgtctg tgtgagtg tcgtgt chr8:58162275-58162295 8 6.43e-05 GTCAGGg tgtgagtg tatgt chr17:78198077-78198097 6 6.43e-05 gcgtg tgtgagtg agtgtgc chr15:41206410-41206430 4 6.43e-05 gtg tgtgagtg tacgactgt chr16:31343249-31343269 6 6.43e-05 ccatg tgtgagtg tgtgcaa chr19:46461821-46461841 9 6.43e-05 tgtgaggg tgtgagtg tgaa chr19:39648800-39648820 10 6.43e-05 gtgcatgtt tgtgagtg tgc chrX:152705588-152705608 2 6.43e-05 g tgtgagtg ctagtgtgtg chr10:127817383-12781740 9 6.43e-05 cctgcgca tgtgagtg tgtg chr12:125000206-12500022 12 6.43e-05 tgcatgtgag tgtgagtg t chr11:68118438-68118458 3 6.43e-05 cg tgtgagtg gatatttgtg chr19:19097906-19097926 6 7.99e-05 gtatG TGCATGTG TGCACGC chr3:54751760-54751780 2 7.99e-05 g tgcatgtg tggtgtggtg chr8:81871503-81871523 8 7.99e-05 gtgtgcg tgcatgtg tgatg chr17:72541449-72541469 5 7.99e-05 tgtg tgcatgtg tgactgtg chr22:46338827-46338847 11 7.99e-05 gtgtgcagtg tgcatgtg tg chr10:1568002-1568022 11 1.15e-04 agcatgtacg tgtgtgcg ca chr2:241288762-241288782 5 1.15e-04 cgag tgtgtgcg cacgtgtg chr11:65810662-65810682 5 1.15e-04 GTGT TGTGTGCG AACATGGC chr17:62932453-62932473 5 1.30e-04 catt tgtgtgta catttatg chr6:29949272-29949292 4 1.30e-04 gcc tgtgtgta tcagttagc chr21:43488844-43488864 8 1.30e-04 ttgtaag tgtgtgta agtgt chr10:134775407-13477542 10 1.46e-04 tgacaggca tgtgtgag cat chr9:34653237-34653257 1 1.60e-04 . tgtaagtg tgtctgagtc chr5:10538378-10538398 2 1.76e-04 g agtgtgtg cctgcatgag chr17:75800029-75800049 11 1.91e-04 tgcgcatgca tgtctgtg ca chr2:241440627-241440647 5 1.91e-04 tgcg tgtctgtg catgagtg chr1:22896788-22896808 12 2.41e-04 tgcacacgtg tgcgtgta c chr17:78264186-78264206 1 2.41e-04 . tgcgtgta cgtgtgcttg chr17:16311551-16311571 1 2.58e-04 . TGCGTGAG AAATTATCTC chr17:21247819-21247839 9 3.04e-04 actatgag tatgtgtg actc chr7:154900403-154900423 13 3.04e-04 cgtgcatgag tgcaagtg chr19:46171033-46171053 9 3.19e-04 TACATGAC TGTGTGTC ACAG chr2:121035620-121035640 12 3.68e-04 tgtgaatgtg agcgtgtg t chr19:7972259-7972279 8 3.68e-04 TGCCCCG GGTGTGTG TTGTG chr9:129946683-129946703 6 4.17e-04 CTGCA TGTATGAG AAACAAT chr6:166121131-166121151 13 4.17e-04 tttgggtata tgtgagcg chr4:1331196-1331216 7 4.17e-04 TGTCCC TGCCTGTG ACTGAC chr14:105223011-10522303 4 4.17e-04 CAG TGTGAGCG AGCCCTGTG chr2:27342078-27342098 12 4.17e-04 CGTGTGACAT tgtgagcg t chr2:10156280-10156300 11 4.32e-04 tgggcagacg tgcgtatg gg chr3:195614751-195614771 13 5.50e-04 cgtacgcacg tgcatgcg chr1:226837196-226837216 2 5.50e-04 g tgcatgcg tgatatgtgc chr4:8375162-8375182 2 5.83e-04 G TGCGTGTC AGTCTGGGTG chr9:96411998-96412018 3 6.81e-04 AA TGCATGAG ACATTCATGA chr7:101961440-101961460 11 6.81e-04 tgtgcgcata tgcatgag cg chr8:6604172-6604192 3 7.54e-04 CG TGCTTGTG GGAATCTTTG chr3:16246436-16246456 11 8.02e-04 ggggggagcg agcatgtg cg chr16:86107897-86107917 13 8.02e-04 taagtgtgca agcatgtg chr7:151587269-151587289 2 8.47e-04 g ttcgtgtg cgcatgcgta chr15:67225088-67225108 9 8.90e-04 CTcacaca tgcatatg ctca chr10:99685481-99685501 2 9.56e-04 g ggtgagtg agAATGAGTG chr12:66466567-66466587 5 1.12e-03 GGTC TACATGTG AAAATTTC chr11:64463175-64463195 10 1.19e-03 ACTCCTAGG TGTGTATa cac -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr11:123121879-12312189 1.6e-05 8_[+1]_4 chr22:39157920-39157940 1.6e-05 7_[+1]_5 chr22:29607626-29607646 1.6e-05 7_[+1]_5 chr17:80681438-80681458 1.6e-05 3_[+1]_9 chr7:98674458-98674478 1.6e-05 6_[+1]_6 chr8:134820664-134820684 1.6e-05 3_[+1]_9 chr22:36029736-36029756 1.6e-05 4_[+1]_8 chr18:77557592-77557612 1.6e-05 3_[+1]_9 chr6:37537282-37537302 1.6e-05 7_[+1]_5 chr19:42409629-42409649 1.6e-05 4_[+1]_8 chr16:29679266-29679286 1.6e-05 1_[+1]_11 chr12:124818497-12481851 1.6e-05 5_[+1]_7 chr13:114497782-11449780 1.6e-05 6_[+1]_6 chr19:3808160-3808180 1.6e-05 1_[+1]_11 chr12:54944138-54944158 1.6e-05 12_[+1] chr18:28565913-28565933 1.6e-05 5_[+1]_7 chr18:13590056-13590076 1.6e-05 8_[+1]_4 chr21:43339263-43339283 1.6e-05 12_[+1] chr20:56371365-56371385 1.6e-05 9_[+1]_3 chr17:35174387-35174407 1.6e-05 6_[+1]_6 chr1:3608549-3608569 1.6e-05 4_[+1]_8 chr21:46408362-46408382 1.6e-05 12_[+1] chr1:25190744-25190764 1.6e-05 11_[+1]_1 chr21:46529148-46529168 1.6e-05 2_[+1]_10 chr9:36843062-36843082 1.6e-05 5_[+1]_7 chr5:172179316-172179336 1.6e-05 11_[+1]_1 chr5:148772545-148772565 1.6e-05 8_[+1]_4 chr17:19649990-19650010 1.6e-05 10_[+1]_2 chr17:72182745-72182765 1.6e-05 11_[+1]_1 chr3:50305909-50305929 1.6e-05 10_[+1]_2 chr1:25912995-25913015 1.6e-05 8_[+1]_4 chr9:130348495-130348515 1.6e-05 10_[+1]_2 chr1:11894141-11894161 1.6e-05 10_[+1]_2 chr19:19185511-19185531 1.6e-05 3_[+1]_9 chr10:3441725-3441745 3.4e-05 3_[+1]_9 chr17:62077162-62077182 3.4e-05 3_[+1]_9 chr10:23437301-23437321 3.4e-05 12_[+1] chr20:61967881-61967901 3.4e-05 6_[+1]_6 chr12:804457-804477 3.4e-05 7_[+1]_5 chr13:21596391-21596411 3.4e-05 8_[+1]_4 chr2:220330593-220330613 3.4e-05 6_[+1]_6 chr7:55504346-55504366 3.4e-05 3_[+1]_9 chr12:125161493-12516151 4.8e-05 7_[+1]_5 chr1:25297620-25297640 4.8e-05 1_[+1]_11 chr16:1777295-1777315 6.4e-05 6_[+1]_6 chr8:58162275-58162295 6.4e-05 7_[+1]_5 chr17:78198077-78198097 6.4e-05 5_[+1]_7 chr15:41206410-41206430 6.4e-05 3_[+1]_9 chr16:31343249-31343269 6.4e-05 5_[+1]_7 chr19:46461821-46461841 6.4e-05 8_[+1]_4 chr19:39648800-39648820 6.4e-05 9_[+1]_3 chrX:152705588-152705608 6.4e-05 1_[+1]_11 chr10:127817383-12781740 6.4e-05 8_[+1]_4 chr12:125000206-12500022 6.4e-05 11_[+1]_1 chr11:68118438-68118458 6.4e-05 2_[+1]_10 chr19:19097906-19097926 8e-05 5_[+1]_7 chr3:54751760-54751780 8e-05 1_[+1]_11 chr8:81871503-81871523 8e-05 7_[+1]_5 chr17:72541449-72541469 8e-05 4_[+1]_8 chr22:46338827-46338847 8e-05 10_[+1]_2 chr10:1568002-1568022 0.00012 10_[+1]_2 chr2:241288762-241288782 0.00012 4_[+1]_8 chr11:65810662-65810682 0.00012 4_[+1]_8 chr17:62932453-62932473 0.00013 4_[+1]_8 chr6:29949272-29949292 0.00013 3_[+1]_9 chr21:43488844-43488864 0.00013 7_[+1]_5 chr10:134775407-13477542 0.00015 9_[+1]_3 chr9:34653237-34653257 0.00016 [+1]_12 chr5:10538378-10538398 0.00018 1_[+1]_11 chr17:75800029-75800049 0.00019 10_[+1]_2 chr2:241440627-241440647 0.00019 4_[+1]_8 chr1:22896788-22896808 0.00024 11_[+1]_1 chr17:78264186-78264206 0.00024 [+1]_12 chr17:16311551-16311571 0.00026 [+1]_12 chr17:21247819-21247839 0.0003 8_[+1]_4 chr7:154900403-154900423 0.0003 12_[+1] chr19:46171033-46171053 0.00032 8_[+1]_4 chr2:121035620-121035640 0.00037 11_[+1]_1 chr19:7972259-7972279 0.00037 7_[+1]_5 chr9:129946683-129946703 0.00042 5_[+1]_7 chr6:166121131-166121151 0.00042 12_[+1] chr4:1331196-1331216 0.00042 6_[+1]_6 chr14:105223011-10522303 0.00042 3_[+1]_9 chr2:27342078-27342098 0.00042 11_[+1]_1 chr2:10156280-10156300 0.00043 10_[+1]_2 chr3:195614751-195614771 0.00055 12_[+1] chr1:226837196-226837216 0.00055 1_[+1]_11 chr4:8375162-8375182 0.00058 1_[+1]_11 chr9:96411998-96412018 0.00068 2_[+1]_10 chr7:101961440-101961460 0.00068 10_[+1]_2 chr8:6604172-6604192 0.00075 2_[+1]_10 chr3:16246436-16246456 0.0008 10_[+1]_2 chr16:86107897-86107917 0.0008 12_[+1] chr7:151587269-151587289 0.00085 1_[+1]_11 chr15:67225088-67225108 0.00089 8_[+1]_4 chr10:99685481-99685501 0.00096 1_[+1]_11 chr12:66466567-66466587 0.0011 4_[+1]_8 chr11:64463175-64463195 0.0012 9_[+1]_3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGTGTGTG width=8 seqs=98 chr11:123121879-12312189 ( 9) TGTGTGTG 1 chr22:39157920-39157940 ( 8) TGTGTGTG 1 chr22:29607626-29607646 ( 8) TGTGTGTG 1 chr17:80681438-80681458 ( 4) TGTGTGTG 1 chr7:98674458-98674478 ( 7) TGTGTGTG 1 chr8:134820664-134820684 ( 4) TGTGTGTG 1 chr22:36029736-36029756 ( 5) TGTGTGTG 1 chr18:77557592-77557612 ( 4) TGTGTGTG 1 chr6:37537282-37537302 ( 8) TGTGTGTG 1 chr19:42409629-42409649 ( 5) TGTGTGTG 1 chr16:29679266-29679286 ( 2) TGTGTGTG 1 chr12:124818497-12481851 ( 6) TGTGTGTG 1 chr13:114497782-11449780 ( 7) TGTGTGTG 1 chr19:3808160-3808180 ( 2) TGTGTGTG 1 chr12:54944138-54944158 ( 13) TGTGTGTG 1 chr18:28565913-28565933 ( 6) TGTGTGTG 1 chr18:13590056-13590076 ( 9) TGTGTGTG 1 chr21:43339263-43339283 ( 13) TGTGTGTG 1 chr20:56371365-56371385 ( 10) TGTGTGTG 1 chr17:35174387-35174407 ( 7) TGTGTGTG 1 chr1:3608549-3608569 ( 5) TGTGTGTG 1 chr21:46408362-46408382 ( 13) TGTGTGTG 1 chr1:25190744-25190764 ( 12) TGTGTGTG 1 chr21:46529148-46529168 ( 3) TGTGTGTG 1 chr9:36843062-36843082 ( 6) TGTGTGTG 1 chr5:172179316-172179336 ( 12) TGTGTGTG 1 chr5:148772545-148772565 ( 9) TGTGTGTG 1 chr17:19649990-19650010 ( 11) TGTGTGTG 1 chr17:72182745-72182765 ( 12) TGTGTGTG 1 chr3:50305909-50305929 ( 11) TGTGTGTG 1 chr1:25912995-25913015 ( 9) TGTGTGTG 1 chr9:130348495-130348515 ( 11) TGTGTGTG 1 chr1:11894141-11894161 ( 11) TGTGTGTG 1 chr19:19185511-19185531 ( 4) TGTGTGTG 1 chr10:3441725-3441745 ( 4) TGCGTGTG 1 chr17:62077162-62077182 ( 4) TGCGTGTG 1 chr10:23437301-23437321 ( 13) TGCGTGTG 1 chr20:61967881-61967901 ( 7) TGCGTGTG 1 chr12:804457-804477 ( 8) TGCGTGTG 1 chr13:21596391-21596411 ( 9) TGCGTGTG 1 chr2:220330593-220330613 ( 7) TGCGTGTG 1 chr7:55504346-55504366 ( 4) TGCGTGTG 1 chr12:125161493-12516151 ( 8) TGTATGTG 1 chr1:25297620-25297640 ( 2) TGTATGTG 1 chr16:1777295-1777315 ( 7) TGTGAGTG 1 chr8:58162275-58162295 ( 8) TGTGAGTG 1 chr17:78198077-78198097 ( 6) TGTGAGTG 1 chr15:41206410-41206430 ( 4) TGTGAGTG 1 chr16:31343249-31343269 ( 6) TGTGAGTG 1 chr19:46461821-46461841 ( 9) TGTGAGTG 1 chr19:39648800-39648820 ( 10) TGTGAGTG 1 chrX:152705588-152705608 ( 2) TGTGAGTG 1 chr10:127817383-12781740 ( 9) TGTGAGTG 1 chr12:125000206-12500022 ( 12) TGTGAGTG 1 chr11:68118438-68118458 ( 3) TGTGAGTG 1 chr19:19097906-19097926 ( 6) TGCATGTG 1 chr3:54751760-54751780 ( 2) TGCATGTG 1 chr8:81871503-81871523 ( 8) TGCATGTG 1 chr17:72541449-72541469 ( 5) TGCATGTG 1 chr22:46338827-46338847 ( 11) TGCATGTG 1 chr10:1568002-1568022 ( 11) TGTGTGCG 1 chr2:241288762-241288782 ( 5) TGTGTGCG 1 chr11:65810662-65810682 ( 5) TGTGTGCG 1 chr17:62932453-62932473 ( 5) TGTGTGTA 1 chr6:29949272-29949292 ( 4) TGTGTGTA 1 chr21:43488844-43488864 ( 8) TGTGTGTA 1 chr10:134775407-13477542 ( 10) TGTGTGAG 1 chr9:34653237-34653257 ( 1) TGTAAGTG 1 chr5:10538378-10538398 ( 2) AGTGTGTG 1 chr17:75800029-75800049 ( 11) TGTCTGTG 1 chr2:241440627-241440647 ( 5) TGTCTGTG 1 chr1:22896788-22896808 ( 12) TGCGTGTA 1 chr17:78264186-78264206 ( 1) TGCGTGTA 1 chr17:16311551-16311571 ( 1) TGCGTGAG 1 chr17:21247819-21247839 ( 9) TATGTGTG 1 chr7:154900403-154900423 ( 13) TGCAAGTG 1 chr19:46171033-46171053 ( 9) TGTGTGTC 1 chr2:121035620-121035640 ( 12) AGCGTGTG 1 chr19:7972259-7972279 ( 8) GGTGTGTG 1 chr9:129946683-129946703 ( 6) TGTATGAG 1 chr6:166121131-166121151 ( 13) TGTGAGCG 1 chr4:1331196-1331216 ( 7) TGCCTGTG 1 chr14:105223011-10522303 ( 4) TGTGAGCG 1 chr2:27342078-27342098 ( 12) TGTGAGCG 1 chr2:10156280-10156300 ( 11) TGCGTATG 1 chr3:195614751-195614771 ( 13) TGCATGCG 1 chr1:226837196-226837216 ( 2) TGCATGCG 1 chr4:8375162-8375182 ( 2) TGCGTGTC 1 chr9:96411998-96412018 ( 3) TGCATGAG 1 chr7:101961440-101961460 ( 11) TGCATGAG 1 chr8:6604172-6604192 ( 3) TGCTTGTG 1 chr3:16246436-16246456 ( 11) AGCATGTG 1 chr16:86107897-86107917 ( 13) AGCATGTG 1 chr7:151587269-151587289 ( 2) TTCGTGTG 1 chr15:67225088-67225108 ( 9) TGCATATG 1 chr10:99685481-99685501 ( 2) GGTGAGTG 1 chr12:66466567-66466587 ( 5) TACATGTG 1 chr11:64463175-64463195 ( 10) TGTGTATA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.14777 E= 2.8e-135 -251 -1326 -371 198 -351 -1326 186 -454 -1326 28 -1326 153 -35 -309 153 -454 -43 -1326 -1326 180 -293 -1326 186 -1326 -219 -168 -1326 187 -193 -368 178 -1326 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 98 E= 2.8e-135 0.040816 0.000000 0.020408 0.938776 0.020408 0.000000 0.969388 0.010204 0.000000 0.316327 0.000000 0.683673 0.183673 0.030612 0.775510 0.010204 0.173469 0.000000 0.000000 0.826531 0.030612 0.000000 0.969388 0.000000 0.051020 0.081633 0.000000 0.867347 0.061224 0.020408 0.918367 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGTGTGTG MEME-1 regular expression -------------------------------------------------------------------------------- TG[TC]GTGTG -------------------------------------------------------------------------------- Time 3.84 secs. ******************************************************************************** ******************************************************************************** MOTIF CACACACA MEME-2 width = 8 sites = 88 llr = 706 E-value = 7.2e-120 ******************************************************************************** -------------------------------------------------------------------------------- Motif CACACACA MEME-2 Description -------------------------------------------------------------------------------- Simplified A :9:8:8:8 pos.-specific C a:9:a1a: probability G :1:2:::2 matrix T :11::1:: bits 2.1 1.9 * 1.7 * * * 1.5 * * * * Relative 1.3 *** * ** Entropy 1.0 ******** (11.6 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CACACACA consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACACACA MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:39820055-39820075 6 1.37e-05 ccagt cacacaca ggctgtc chr12:3215012-3215032 11 1.37e-05 cacacacgtt cacacaca ca chr14:99787812-99787832 3 1.37e-05 cc cacacaca cctatacaca chr20:62478602-62478622 8 1.37e-05 acactga cacacaca agcag chr17:75869181-75869201 12 1.37e-05 cgcacacacg cacacaca a chr14:35822280-35822300 11 1.37e-05 ctcacacata cacacaca cg chr10:14013137-14013157 2 1.37e-05 t cacacaca tgcatgcata chr11:78777735-78777755 9 1.37e-05 cactcgag cacacaca cgca chr2:9606474-9606494 10 1.37e-05 gcgcgcgca cacacaca cgc chr12:48338646-48338666 3 1.37e-05 tg cacacaca cgcacatatg chr11:65577990-65578010 11 1.37e-05 tacacactcg cacacaca tg chr12:131148945-13114896 12 1.37e-05 cgcacgcacg cacacaca c chr14:77624850-77624870 9 1.37e-05 tcacacat cacacaca catc chr8:29949364-29949384 7 1.37e-05 aggacg cacacaca cgcaca chr13:100555643-10055566 6 1.37e-05 actga cacacaca tacactc chr13:113773888-11377390 12 1.37e-05 cacacagatg cacacaca g chr17:74273775-74273795 7 1.37e-05 tacatg cacacaca tactca chr19:47140582-47140602 6 1.37e-05 CCTGT CACACACA CGCACGC chr17:3593174-3593194 3 1.37e-05 ca cacacaca aacgcacgca chr12:124338404-12433842 6 1.37e-05 gcgca cacacaca cggatac chr2:112918273-112918293 11 1.37e-05 cacgcacgca cacacaca ag chr17:79943001-79943021 4 1.37e-05 atg cacacaca cgcacatct chr8:10427804-10427824 7 1.37e-05 GAATCA CACACACA TCTGTG chr1:2303672-2303692 3 1.37e-05 tg cacacaca tacaggagca chr15:93586482-93586502 7 1.37e-05 cacgca cacacaca ggcatg chr17:81028883-81028903 12 2.94e-05 cactcgagca cacgcaca c chr11:61301909-61301929 5 2.94e-05 cacg cacgcaca cacgcacg chr11:68616091-68616111 2 2.94e-05 a cacgcaca cgcacacacg chr1:2280269-2280289 2 2.94e-05 a cacgcaca cctgcgcggg chr2:127801345-127801365 5 2.94e-05 ttcg cacgcaca ctcgtgca chr12:1925990-1926010 13 2.94e-05 catacccatg cacgcaca chr14:35832204-35832224 1 2.94e-05 . cacgcaca cggacacatg chr17:78913161-78913181 13 4.51e-05 cacgcactcg cacacacg chr16:28050983-28051003 4 4.51e-05 atg cacacacg tatgcacac chr22:44542108-44542128 7 4.51e-05 cacgct cacacacg cgctca chr14:99850179-99850199 2 4.51e-05 a cacacacg ttcacacacc chr19:1642250-1642270 8 4.51e-05 acgtgcg cacacacg cacgc chr16:30907092-30907112 12 4.51e-05 aatccactcg cacacacg c chr7:154415306-154415326 8 4.51e-05 acgctga cacacacg cacgt chr17:4415996-4416016 6 4.51e-05 gtgtg cacacacg tgcgtgc chr21:46730071-46730091 8 5.76e-05 acacatc catacaca tgaac chr2:240428879-240428899 9 5.76e-05 CGCACACG CATACACA TATG chr19:1389203-1389223 10 5.76e-05 gcttgcaca catacaca cat chr2:3467936-3467956 8 5.76e-05 tcacact catacaca atgct chr11:2310186-2310206 2 5.76e-05 g catacaca tgtacccaca chr13:111288725-11128874 1 5.76e-05 . catacaca tgcacagttg chr10:21503460-21503480 3 5.76e-05 ca catacaca catgcacaca chr14:105058844-10505886 6 7.15e-05 acatg cacactca tgcacac chr2:235209765-235209785 3 7.15e-05 ga cacactca gatgcatgca chr17:7013056-7013076 8 7.15e-05 ATTTGCA CACACTCA TGACC chr17:79122590-79122610 11 7.15e-05 cgcatatgca cacactca cg chr11:123421128-12342114 12 7.15e-05 ctctctcatg cacactca c chr5:149643046-149643066 11 7.15e-05 catacactca cacactca ca chr15:67225088-67225108 1 8.54e-05 . CTcacaca tgcatatgct chr11:47377416-47377436 4 8.54e-05 atg ctcacaca tcacgccca chr17:76694221-76694241 9 1.01e-04 cacgcacg cgcacaca tgca chr8:144636691-144636711 13 1.01e-04 CGTGcacaaa cgcacaca chr19:3831018-3831038 4 1.01e-04 atg cgcacaca tacgtgcaa chr17:35013884-35013904 10 1.01e-04 acacactcg cgcacaca ccc chr20:61168318-61168338 7 1.16e-04 cacgtg cacaccca gacaca chr17:80005323-80005343 12 1.16e-04 cacaagtgca cacaccca c chr12:125023764-12502378 11 1.16e-04 CCCCTGTGCT CACACCCA CC chr5:6687786-6687806 9 1.16e-04 cactcagt cacaccca cctg chr1:30216290-30216310 12 1.45e-04 tttgctcaaa tacacaca t chr1:1165306-1165326 8 1.45e-04 cacgtat tacacaca TGTGC chr8:143381036-143381056 10 1.45e-04 cacatgcat cacacgca tgc chr15:78088597-78088617 2 1.45e-04 t tacacaca taGATGTGTT chr16:87097310-87097330 1 1.45e-04 . cacacgca cccagacaca chr17:38220624-38220644 13 1.58e-04 AAGACCCTGT CACTCACA chr2:26784872-26784892 7 1.77e-04 cacatg cacgcacg cacgca chr9:138899340-138899360 6 1.91e-04 acaca catgcaca gacgcgc chr17:982443-982463 5 2.34e-04 cgct cacgctca cacgcgct chr20:23425673-23425693 7 2.78e-04 aatgct catactca cgacac chr18:11861837-11861857 8 2.78e-04 TCTCGCT CTCGCACA CTTTC chr4:146444442-146444462 10 3.25e-04 CAGCTAACT CTTACACA CCC chr17:77995679-77995699 11 3.58e-04 gacacacaaa cacacacc at chr19:4543063-4543083 3 3.58e-04 CA CACGCCCA CAGCAGCCTT chr17:79131166-79131186 8 4.04e-04 TCATAGA CGCACACG TACCC chr1:55545515-55545535 2 4.04e-04 a cacacaga gtactcgtgc chr2:240212363-240212383 13 4.68e-04 attcagttcg cacgcgca chr15:57612491-57612511 3 7.19e-04 ag cacacatg cacttgcacg chr16:4740577-4740597 11 7.63e-04 cccacttgca catgctca cg chr1:42611896-42611916 13 7.77e-04 catgcccata ctctcaca chr9:132754501-132754521 9 8.55e-04 CTTGAGAG CTCGCACG TAGC chr22:25779996-25780016 13 9.17e-04 tacaaatatc cgctcaca chr20:44845893-44845913 9 1.03e-03 cagataga ctcacata cttg chr10:3441725-3441745 12 1.27e-03 gatgcgtgtg cacgcgcg t chr3:195614751-195614771 5 1.27e-03 tgcg tacgcacg tgcatgcg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACACACA MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:39820055-39820075 1.4e-05 5_[+2]_7 chr12:3215012-3215032 1.4e-05 10_[+2]_2 chr14:99787812-99787832 1.4e-05 2_[+2]_10 chr20:62478602-62478622 1.4e-05 7_[+2]_5 chr17:75869181-75869201 1.4e-05 11_[+2]_1 chr14:35822280-35822300 1.4e-05 10_[+2]_2 chr10:14013137-14013157 1.4e-05 1_[+2]_11 chr11:78777735-78777755 1.4e-05 8_[+2]_4 chr2:9606474-9606494 1.4e-05 9_[+2]_3 chr12:48338646-48338666 1.4e-05 2_[+2]_10 chr11:65577990-65578010 1.4e-05 10_[+2]_2 chr12:131148945-13114896 1.4e-05 11_[+2]_1 chr14:77624850-77624870 1.4e-05 8_[+2]_4 chr8:29949364-29949384 1.4e-05 6_[+2]_6 chr13:100555643-10055566 1.4e-05 5_[+2]_7 chr13:113773888-11377390 1.4e-05 11_[+2]_1 chr17:74273775-74273795 1.4e-05 6_[+2]_6 chr19:47140582-47140602 1.4e-05 5_[+2]_7 chr17:3593174-3593194 1.4e-05 2_[+2]_10 chr12:124338404-12433842 1.4e-05 5_[+2]_7 chr2:112918273-112918293 1.4e-05 10_[+2]_2 chr17:79943001-79943021 1.4e-05 3_[+2]_9 chr8:10427804-10427824 1.4e-05 6_[+2]_6 chr1:2303672-2303692 1.4e-05 2_[+2]_10 chr15:93586482-93586502 1.4e-05 6_[+2]_6 chr17:81028883-81028903 2.9e-05 11_[+2]_1 chr11:61301909-61301929 2.9e-05 4_[+2]_8 chr11:68616091-68616111 2.9e-05 1_[+2]_11 chr1:2280269-2280289 2.9e-05 1_[+2]_11 chr2:127801345-127801365 2.9e-05 4_[+2]_8 chr12:1925990-1926010 2.9e-05 12_[+2] chr14:35832204-35832224 2.9e-05 [+2]_12 chr17:78913161-78913181 4.5e-05 12_[+2] chr16:28050983-28051003 4.5e-05 3_[+2]_9 chr22:44542108-44542128 4.5e-05 6_[+2]_6 chr14:99850179-99850199 4.5e-05 1_[+2]_11 chr19:1642250-1642270 4.5e-05 7_[+2]_5 chr16:30907092-30907112 4.5e-05 11_[+2]_1 chr7:154415306-154415326 4.5e-05 7_[+2]_5 chr17:4415996-4416016 4.5e-05 5_[+2]_7 chr21:46730071-46730091 5.8e-05 7_[+2]_5 chr2:240428879-240428899 5.8e-05 8_[+2]_4 chr19:1389203-1389223 5.8e-05 9_[+2]_3 chr2:3467936-3467956 5.8e-05 7_[+2]_5 chr11:2310186-2310206 5.8e-05 1_[+2]_11 chr13:111288725-11128874 5.8e-05 [+2]_12 chr10:21503460-21503480 5.8e-05 2_[+2]_10 chr14:105058844-10505886 7.1e-05 5_[+2]_7 chr2:235209765-235209785 7.1e-05 2_[+2]_10 chr17:7013056-7013076 7.1e-05 7_[+2]_5 chr17:79122590-79122610 7.1e-05 10_[+2]_2 chr11:123421128-12342114 7.1e-05 11_[+2]_1 chr5:149643046-149643066 7.1e-05 10_[+2]_2 chr15:67225088-67225108 8.5e-05 [+2]_12 chr11:47377416-47377436 8.5e-05 3_[+2]_9 chr17:76694221-76694241 0.0001 8_[+2]_4 chr8:144636691-144636711 0.0001 12_[+2] chr19:3831018-3831038 0.0001 3_[+2]_9 chr17:35013884-35013904 0.0001 9_[+2]_3 chr20:61168318-61168338 0.00012 6_[+2]_6 chr17:80005323-80005343 0.00012 11_[+2]_1 chr12:125023764-12502378 0.00012 10_[+2]_2 chr5:6687786-6687806 0.00012 8_[+2]_4 chr1:30216290-30216310 0.00014 11_[+2]_1 chr1:1165306-1165326 0.00014 7_[+2]_5 chr8:143381036-143381056 0.00014 9_[+2]_3 chr15:78088597-78088617 0.00014 1_[+2]_11 chr16:87097310-87097330 0.00014 [+2]_12 chr17:38220624-38220644 0.00016 12_[+2] chr2:26784872-26784892 0.00018 6_[+2]_6 chr9:138899340-138899360 0.00019 5_[+2]_7 chr17:982443-982463 0.00023 4_[+2]_8 chr20:23425673-23425693 0.00028 6_[+2]_6 chr18:11861837-11861857 0.00028 7_[+2]_5 chr4:146444442-146444462 0.00032 9_[+2]_3 chr17:77995679-77995699 0.00036 10_[+2]_2 chr19:4543063-4543083 0.00036 2_[+2]_10 chr17:79131166-79131186 0.0004 7_[+2]_5 chr1:55545515-55545535 0.0004 1_[+2]_11 chr2:240212363-240212383 0.00047 12_[+2] chr15:57612491-57612511 0.00072 2_[+2]_10 chr16:4740577-4740597 0.00076 10_[+2]_2 chr1:42611896-42611916 0.00078 12_[+2] chr9:132754501-132754521 0.00085 8_[+2]_4 chr22:25779996-25780016 0.00092 12_[+2] chr20:44845893-44845913 0.001 8_[+2]_4 chr10:3441725-3441745 0.0013 11_[+2]_1 chr3:195614751-195614771 0.0013 4_[+2]_8 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACACACA MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CACACACA width=8 seqs=88 chr19:39820055-39820075 ( 6) CACACACA 1 chr12:3215012-3215032 ( 11) CACACACA 1 chr14:99787812-99787832 ( 3) CACACACA 1 chr20:62478602-62478622 ( 8) CACACACA 1 chr17:75869181-75869201 ( 12) CACACACA 1 chr14:35822280-35822300 ( 11) CACACACA 1 chr10:14013137-14013157 ( 2) CACACACA 1 chr11:78777735-78777755 ( 9) CACACACA 1 chr2:9606474-9606494 ( 10) CACACACA 1 chr12:48338646-48338666 ( 3) CACACACA 1 chr11:65577990-65578010 ( 11) CACACACA 1 chr12:131148945-13114896 ( 12) CACACACA 1 chr14:77624850-77624870 ( 9) CACACACA 1 chr8:29949364-29949384 ( 7) CACACACA 1 chr13:100555643-10055566 ( 6) CACACACA 1 chr13:113773888-11377390 ( 12) CACACACA 1 chr17:74273775-74273795 ( 7) CACACACA 1 chr19:47140582-47140602 ( 6) CACACACA 1 chr17:3593174-3593194 ( 3) CACACACA 1 chr12:124338404-12433842 ( 6) CACACACA 1 chr2:112918273-112918293 ( 11) CACACACA 1 chr17:79943001-79943021 ( 4) CACACACA 1 chr8:10427804-10427824 ( 7) CACACACA 1 chr1:2303672-2303692 ( 3) CACACACA 1 chr15:93586482-93586502 ( 7) CACACACA 1 chr17:81028883-81028903 ( 12) CACGCACA 1 chr11:61301909-61301929 ( 5) CACGCACA 1 chr11:68616091-68616111 ( 2) CACGCACA 1 chr1:2280269-2280289 ( 2) CACGCACA 1 chr2:127801345-127801365 ( 5) CACGCACA 1 chr12:1925990-1926010 ( 13) CACGCACA 1 chr14:35832204-35832224 ( 1) CACGCACA 1 chr17:78913161-78913181 ( 13) CACACACG 1 chr16:28050983-28051003 ( 4) CACACACG 1 chr22:44542108-44542128 ( 7) CACACACG 1 chr14:99850179-99850199 ( 2) CACACACG 1 chr19:1642250-1642270 ( 8) CACACACG 1 chr16:30907092-30907112 ( 12) CACACACG 1 chr7:154415306-154415326 ( 8) CACACACG 1 chr17:4415996-4416016 ( 6) CACACACG 1 chr21:46730071-46730091 ( 8) CATACACA 1 chr2:240428879-240428899 ( 9) CATACACA 1 chr19:1389203-1389223 ( 10) CATACACA 1 chr2:3467936-3467956 ( 8) CATACACA 1 chr11:2310186-2310206 ( 2) CATACACA 1 chr13:111288725-11128874 ( 1) CATACACA 1 chr10:21503460-21503480 ( 3) CATACACA 1 chr14:105058844-10505886 ( 6) CACACTCA 1 chr2:235209765-235209785 ( 3) CACACTCA 1 chr17:7013056-7013076 ( 8) CACACTCA 1 chr17:79122590-79122610 ( 11) CACACTCA 1 chr11:123421128-12342114 ( 12) CACACTCA 1 chr5:149643046-149643066 ( 11) CACACTCA 1 chr15:67225088-67225108 ( 1) CTCACACA 1 chr11:47377416-47377436 ( 4) CTCACACA 1 chr17:76694221-76694241 ( 9) CGCACACA 1 chr8:144636691-144636711 ( 13) CGCACACA 1 chr19:3831018-3831038 ( 4) CGCACACA 1 chr17:35013884-35013904 ( 10) CGCACACA 1 chr20:61168318-61168338 ( 7) CACACCCA 1 chr17:80005323-80005343 ( 12) CACACCCA 1 chr12:125023764-12502378 ( 11) CACACCCA 1 chr5:6687786-6687806 ( 9) CACACCCA 1 chr1:30216290-30216310 ( 12) TACACACA 1 chr1:1165306-1165326 ( 8) TACACACA 1 chr8:143381036-143381056 ( 10) CACACGCA 1 chr15:78088597-78088617 ( 2) TACACACA 1 chr16:87097310-87097330 ( 1) CACACGCA 1 chr17:38220624-38220644 ( 13) CACTCACA 1 chr2:26784872-26784892 ( 7) CACGCACG 1 chr9:138899340-138899360 ( 6) CATGCACA 1 chr17:982443-982463 ( 5) CACGCTCA 1 chr20:23425673-23425693 ( 7) CATACTCA 1 chr18:11861837-11861857 ( 8) CTCGCACA 1 chr4:146444442-146444462 ( 10) CTTACACA 1 chr17:77995679-77995699 ( 11) CACACACC 1 chr19:4543063-4543083 ( 3) CACGCCCA 1 chr17:79131166-79131186 ( 8) CGCACACG 1 chr1:55545515-55545535 ( 2) CACACAGA 1 chr2:240212363-240212383 ( 13) CACGCGCA 1 chr15:57612491-57612511 ( 3) CACACATG 1 chr16:4740577-4740597 ( 11) CATGCTCA 1 chr1:42611896-42611916 ( 13) CTCTCACA 1 chr9:132754501-132754521 ( 9) CTCGCACG 1 chr22:25779996-25780016 ( 13) CGCTCACA 1 chr20:44845893-44845913 ( 9) CTCACATA 1 chr10:3441725-3441745 ( 12) CACGCGCG 1 chr3:195614751-195614771 ( 5) TACGCACG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACACACA MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.39464 E= 7.2e-120 -1310 187 -1310 -238 187 -1310 -197 -158 -1310 174 -1310 -93 173 -1310 -47 -280 -1310 194 -1310 -1310 177 -220 -256 -121 -1310 189 -455 -338 183 -452 -75 -1310 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACACACA MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 88 E= 7.2e-120 0.000000 0.954545 0.000000 0.045455 0.852273 0.000000 0.068182 0.079545 0.000000 0.875000 0.000000 0.125000 0.772727 0.000000 0.193182 0.034091 0.000000 1.000000 0.000000 0.000000 0.795455 0.056818 0.045455 0.102273 0.000000 0.965909 0.011364 0.022727 0.829545 0.011364 0.159091 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACACACA MEME-2 regular expression -------------------------------------------------------------------------------- CACACACA -------------------------------------------------------------------------------- Time 6.74 secs. ******************************************************************************** ******************************************************************************** MOTIF CACRCACG MEME-3 width = 8 sites = 12 llr = 109 E-value = 9.2e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif CACRCACG MEME-3 Description -------------------------------------------------------------------------------- Simplified A :9:7:8:: pos.-specific C 9:a:a:a1 probability G 11:3:::9 matrix T :::::2:: bits 2.1 1.9 * * * 1.7 ** * * 1.5 *** **** Relative 1.3 *** **** Entropy 1.0 ******** (13.0 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CACACACG consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACRCACG MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr12:3215012-3215032 1 1.57e-05 . cacacacg ttcacacaca chr17:75869181-75869201 4 1.57e-05 acg cacacacg cacacacaa chr11:68616091-68616111 12 1.57e-05 cacgcacacg cacacacg c chr11:61301909-61301929 13 3.38e-05 cgcacgcaca cacgcacg chr17:76694221-76694241 1 3.38e-05 . cacgcacg cgcacacatg chr12:131148945-13114896 4 3.38e-05 acg cacgcacg cacacacac chr2:112918273-112918293 1 3.38e-05 . cacgcacg cacacacaca chr11:65577990-65578010 3 4.98e-05 ta cacactcg cacacacatg chr17:35013884-35013904 2 4.98e-05 a cacactcg cgcacacacc chr14:99850179-99850199 12 6.51e-05 cacacacgtt cacacacc c chr16:87097310-87097330 13 9.97e-05 cacgcaccca gacacacg chr2:240428879-240428899 1 1.18e-04 . CGCACACG CATACACATA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACRCACG MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr12:3215012-3215032 1.6e-05 [+3]_12 chr17:75869181-75869201 1.6e-05 3_[+3]_9 chr11:68616091-68616111 1.6e-05 11_[+3]_1 chr11:61301909-61301929 3.4e-05 12_[+3] chr17:76694221-76694241 3.4e-05 [+3]_12 chr12:131148945-13114896 3.4e-05 3_[+3]_9 chr2:112918273-112918293 3.4e-05 [+3]_12 chr11:65577990-65578010 5e-05 2_[+3]_10 chr17:35013884-35013904 5e-05 1_[+3]_11 chr14:99850179-99850199 6.5e-05 11_[+3]_1 chr16:87097310-87097330 0.0001 12_[+3] chr2:240428879-240428899 0.00012 [+3]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACRCACG MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CACRCACG width=8 seqs=12 chr12:3215012-3215032 ( 1) CACACACG 1 chr17:75869181-75869201 ( 4) CACACACG 1 chr11:68616091-68616111 ( 12) CACACACG 1 chr11:61301909-61301929 ( 13) CACGCACG 1 chr17:76694221-76694241 ( 1) CACGCACG 1 chr12:131148945-13114896 ( 4) CACGCACG 1 chr2:112918273-112918293 ( 1) CACGCACG 1 chr11:65577990-65578010 ( 3) CACACTCG 1 chr17:35013884-35013904 ( 2) CACACTCG 1 chr14:99850179-99850199 ( 12) CACACACC 1 chr16:87097310-87097330 ( 13) GACACACG 1 chr2:240428879-240428899 ( 1) CGCACACG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACRCACG MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.66445 E= 9.2e-002 -1023 181 -168 -1023 197 -1023 -168 -1023 -1023 193 -1023 -1023 151 -1023 32 -1023 -1023 193 -1023 -1023 184 -1023 -1023 -51 -1023 193 -1023 -1023 -1023 -165 177 -1023 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACRCACG MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 12 E= 9.2e-002 0.000000 0.916667 0.083333 0.000000 0.916667 0.000000 0.083333 0.000000 0.000000 1.000000 0.000000 0.000000 0.666667 0.000000 0.333333 0.000000 0.000000 1.000000 0.000000 0.000000 0.833333 0.000000 0.000000 0.166667 0.000000 1.000000 0.000000 0.000000 0.000000 0.083333 0.916667 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CACRCACG MEME-3 regular expression -------------------------------------------------------------------------------- CAC[AG]CACG -------------------------------------------------------------------------------- Time 9.53 secs. ******************************************************************************** ******************************************************************************** MOTIF YGYRTGCA MEME-4 width = 8 sites = 28 llr = 198 E-value = 7.0e-002 ******************************************************************************** -------------------------------------------------------------------------------- Motif YGYRTGCA MEME-4 Description -------------------------------------------------------------------------------- Simplified A 13:4:::8 pos.-specific C 5:5:1:a: probability G :6:6:a:2 matrix T 515:9::: bits 2.1 1.9 ** 1.7 ** 1.5 **** Relative 1.3 **** Entropy 1.0 ****** (10.2 bits) 0.8 ******* 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel CGCGTGCA consensus TATA sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YGYRTGCA MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr16:29679266-29679286 12 3.27e-05 tgtgtgtgta tgtgtgca c chr21:46408362-46408382 5 3.27e-05 tgca tgtgtgca tgtgtgtg chr17:72182745-72182765 4 3.27e-05 atg tgtgtgca tgtgtgtgc chr7:154900403-154900423 1 3.27e-05 . tgcgtgca tgagtgcaag chr10:14013137-14013157 10 9.73e-05 tcacacaca tgcatgca tac chr2:235209765-235209785 13 9.73e-05 cacactcaga tgcatgca chr1:11894141-11894161 3 9.73e-05 tg tgtatgca tgtgtgtgcg chr17:75800029-75800049 3 1.29e-04 tg cgcatgca tgtctgtgca chr19:3831018-3831038 12 1.57e-04 tgcgcacaca tacgtgca a chr1:226837196-226837216 13 1.57e-04 gcatgcgtga tatgtgca chr8:144636691-144636711 1 1.88e-04 . CACGTGca caaacgcaca chr17:79122590-79122610 3 2.40e-04 cg catatgca cacactcacg chr17:65050991-65051011 6 2.40e-04 tgaca catatgca tgacaca chr14:35832204-35832224 13 2.40e-04 cgcacacgga cacatgca chr8:143381036-143381056 1 2.40e-04 . cacatgca tcacacgcat chr5:148772545-148772565 1 2.78e-04 . tgtgtgcg tgtgtgtgct chr7:55504346-55504366 12 2.78e-04 tgtgcgtgtg tgcgtgcg t chr10:23437301-23437321 5 3.20e-04 tgtg cgtgtgcg tgcgtgtg chr16:86107897-86107917 5 3.88e-04 tata agtgtgca agcatgtg chr3:126262523-126262543 1 3.88e-04 . agtgtgca taagtgagta chr7:101961440-101961460 1 3.88e-04 . tgtgcgca tatgcatgag chr2:9606474-9606494 2 4.60e-04 g cgcgcgca cacacacacg chr7:151587269-151587289 10 5.25e-04 gttcgtgtg cgcatgcg tac chr17:78913161-78913181 1 6.17e-04 . tgcacgca ctcgcacaca chr2:127801345-127801365 13 6.17e-04 cgcacgcaca ctcgtgca chr1:55545515-55545535 13 6.17e-04 acacagagta ctcgtgca chr17:3593174-3593194 13 6.51e-04 cacacacaaa cgcacgca chr17:19649990-19650010 1 7.73e-04 . catgtgcg tgtgtgtgtg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YGYRTGCA MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr16:29679266-29679286 3.3e-05 11_[+4]_1 chr21:46408362-46408382 3.3e-05 4_[+4]_8 chr17:72182745-72182765 3.3e-05 3_[+4]_9 chr7:154900403-154900423 3.3e-05 [+4]_12 chr10:14013137-14013157 9.7e-05 9_[+4]_3 chr2:235209765-235209785 9.7e-05 12_[+4] chr1:11894141-11894161 9.7e-05 2_[+4]_10 chr17:75800029-75800049 0.00013 2_[+4]_10 chr19:3831018-3831038 0.00016 11_[+4]_1 chr1:226837196-226837216 0.00016 12_[+4] chr8:144636691-144636711 0.00019 [+4]_12 chr17:79122590-79122610 0.00024 2_[+4]_10 chr17:65050991-65051011 0.00024 5_[+4]_7 chr14:35832204-35832224 0.00024 12_[+4] chr8:143381036-143381056 0.00024 [+4]_12 chr5:148772545-148772565 0.00028 [+4]_12 chr7:55504346-55504366 0.00028 11_[+4]_1 chr10:23437301-23437321 0.00032 4_[+4]_8 chr16:86107897-86107917 0.00039 4_[+4]_8 chr3:126262523-126262543 0.00039 [+4]_12 chr7:101961440-101961460 0.00039 [+4]_12 chr2:9606474-9606494 0.00046 1_[+4]_11 chr7:151587269-151587289 0.00053 9_[+4]_3 chr17:78913161-78913181 0.00062 [+4]_12 chr2:127801345-127801365 0.00062 12_[+4] chr1:55545515-55545535 0.00062 12_[+4] chr17:3593174-3593194 0.00065 12_[+4] chr17:19649990-19650010 0.00077 [+4]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YGYRTGCA MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF YGYRTGCA width=8 seqs=28 chr16:29679266-29679286 ( 12) TGTGTGCA 1 chr21:46408362-46408382 ( 5) TGTGTGCA 1 chr17:72182745-72182765 ( 4) TGTGTGCA 1 chr7:154900403-154900423 ( 1) TGCGTGCA 1 chr10:14013137-14013157 ( 10) TGCATGCA 1 chr2:235209765-235209785 ( 13) TGCATGCA 1 chr1:11894141-11894161 ( 3) TGTATGCA 1 chr17:75800029-75800049 ( 3) CGCATGCA 1 chr19:3831018-3831038 ( 12) TACGTGCA 1 chr1:226837196-226837216 ( 13) TATGTGCA 1 chr8:144636691-144636711 ( 1) CACGTGCA 1 chr17:79122590-79122610 ( 3) CATATGCA 1 chr17:65050991-65051011 ( 6) CATATGCA 1 chr14:35832204-35832224 ( 13) CACATGCA 1 chr8:143381036-143381056 ( 1) CACATGCA 1 chr5:148772545-148772565 ( 1) TGTGTGCG 1 chr7:55504346-55504366 ( 12) TGCGTGCG 1 chr10:23437301-23437321 ( 5) CGTGTGCG 1 chr16:86107897-86107917 ( 5) AGTGTGCA 1 chr3:126262523-126262543 ( 1) AGTGTGCA 1 chr7:101961440-101961460 ( 1) TGTGCGCA 1 chr2:9606474-9606494 ( 2) CGCGCGCA 1 chr7:151587269-151587289 ( 10) CGCATGCG 1 chr17:78913161-78913181 ( 1) TGCACGCA 1 chr2:127801345-127801365 ( 13) CTCGTGCA 1 chr1:55545515-55545535 ( 13) CTCGTGCA 1 chr17:3593174-3593194 ( 13) CGCACGCA 1 chr17:19649990-19650010 ( 1) CATGTGCG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YGYRTGCA MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.07592 E= 7.0e-002 -171 83 -1145 97 29 -1145 126 -173 -1145 103 -1145 97 75 -1145 118 -1145 -1145 -87 -1145 185 -1145 -1145 190 -1145 -1145 194 -1145 -1145 181 -1145 -58 -1145 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YGYRTGCA MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 28 E= 7.0e-002 0.071429 0.464286 0.000000 0.464286 0.285714 0.000000 0.642857 0.071429 0.000000 0.535714 0.000000 0.464286 0.392857 0.000000 0.607143 0.000000 0.000000 0.142857 0.000000 0.857143 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.821429 0.000000 0.178571 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YGYRTGCA MEME-4 regular expression -------------------------------------------------------------------------------- [CT][GA][CT][GA]TGCA -------------------------------------------------------------------------------- Time 11.36 secs. ******************************************************************************** ******************************************************************************** MOTIF TGCATGTG MEME-5 width = 8 sites = 10 llr = 86 E-value = 3.0e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGCATGTG MEME-5 Description -------------------------------------------------------------------------------- Simplified A ::18:11: pos.-specific C ::9::::: probability G :a:129:9 matrix T a::18:91 bits 2.1 * 1.9 ** 1.7 ** * 1.5 *** *** Relative 1.3 ******** Entropy 1.0 ******** (12.4 bits) 0.8 ******** 0.6 ******** 0.4 ******** 0.2 ******** 0.0 -------- Multilevel TGCATGTG consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGCATGTG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr1:25297620-25297640 10 1.56e-05 atgtatgtg tgcatgtg tgt chr12:125000206-12500022 2 1.56e-05 g tgcatgtg agtgtgagtg chr16:88959743-88959763 10 3.32e-05 aatatgcgc tgcaggtg ctt chr19:7252566-7252586 9 3.32e-05 ACGGGCTT TGCAGGTG GTCA chr13:21596391-21596411 1 4.68e-05 . tgcatatg tgcgtgtgca chr2:121035620-121035640 4 7.44e-05 gtg tgaatgtg agcgtgtgt chr19:39648800-39648820 2 7.44e-05 g tgcatgtt tgtgagtgtg chr17:78264186-78264206 13 1.06e-04 cgtgtacgtg tgcttgtg chr5:10538378-10538398 12 1.06e-04 agtgtgtgcc tgcatgag c chr9:130348495-130348515 1 1.24e-04 . tgcgtgtg cttgtgtgtg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGCATGTG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:25297620-25297640 1.6e-05 9_[+5]_3 chr12:125000206-12500022 1.6e-05 1_[+5]_11 chr16:88959743-88959763 3.3e-05 9_[+5]_3 chr19:7252566-7252586 3.3e-05 8_[+5]_4 chr13:21596391-21596411 4.7e-05 [+5]_12 chr2:121035620-121035640 7.4e-05 3_[+5]_9 chr19:39648800-39648820 7.4e-05 1_[+5]_11 chr17:78264186-78264206 0.00011 12_[+5] chr5:10538378-10538398 0.00011 11_[+5]_1 chr9:130348495-130348515 0.00012 [+5]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGCATGTG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGCATGTG width=8 seqs=10 chr1:25297620-25297640 ( 10) TGCATGTG 1 chr12:125000206-12500022 ( 2) TGCATGTG 1 chr16:88959743-88959763 ( 10) TGCAGGTG 1 chr19:7252566-7252586 ( 9) TGCAGGTG 1 chr13:21596391-21596411 ( 1) TGCATATG 1 chr2:121035620-121035640 ( 4) TGAATGTG 1 chr19:39648800-39648820 ( 2) TGCATGTT 1 chr17:78264186-78264206 ( 13) TGCTTGTG 1 chr5:10538378-10538398 ( 12) TGCATGAG 1 chr9:130348495-130348515 ( 1) TGCGTGTG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGCATGTG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.5921 E= 3.0e+003 -997 -997 -997 207 -997 -997 190 -997 -122 178 -997 -997 178 -997 -142 -125 -997 -997 -42 175 -122 -997 175 -997 -122 -997 -997 192 -997 -997 175 -125 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGCATGTG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 10 E= 3.0e+003 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.100000 0.900000 0.000000 0.000000 0.800000 0.000000 0.100000 0.100000 0.000000 0.000000 0.200000 0.800000 0.100000 0.000000 0.900000 0.000000 0.100000 0.000000 0.000000 0.900000 0.000000 0.000000 0.900000 0.100000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGCATGTG MEME-5 regular expression -------------------------------------------------------------------------------- TGCA[TG]GTG -------------------------------------------------------------------------------- Time 11.94 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr7:55504346-55504366 7.50e-06 3_[+1(3.42e-05)]_9 chr16:87097310-87097330 1.40e-04 12_[+3(9.97e-05)] chr16:87530293-87530313 5.57e-01 20 chr7:101961440-101961460 8.33e-06 20 chr17:38220624-38220644 3.82e-02 20 chr18:11861837-11861857 1.42e-02 20 chr19:19185511-19185531 3.33e-05 1_[+1(1.63e-05)]_11 chr11:65810662-65810682 5.27e-04 20 chr1:11894141-11894161 8.62e-08 2_[+4(9.73e-05)]_[+1(1.63e-05)]_2 chr15:93586482-93586502 3.43e-04 4_[+2(1.37e-05)]_8 chr5:6687786-6687806 5.23e-03 20 chr5:142630928-142630948 6.80e-01 20 chr20:56468847-56468867 2.04e-02 20 chr22:46338827-46338847 2.22e-06 10_[+5(1.56e-05)]_2 chr2:220330593-220330613 2.53e-07 12_[+5(1.56e-05)] chr7:154900403-154900423 1.05e-06 [+4(3.27e-05)]_12 chr15:78088597-78088617 3.40e-03 20 chr9:130348495-130348515 3.40e-06 [+1(3.42e-05)]_2_[+1(1.63e-05)]_2 chr17:4415996-4416016 4.32e-06 5_[+3(1.57e-05)]_7 chr1:25912995-25913015 3.25e-05 6_[+1(1.63e-05)]_6 chr3:50305909-50305929 4.33e-06 10_[+1(1.63e-05)]_2 chr17:72182745-72182765 7.23e-08 1_[+1(1.63e-05)]_2_[+1(1.63e-05)]_1 chr3:126262523-126262543 2.53e-04 20 chr19:7252566-7252586 9.92e-03 8_[+5(3.32e-05)]_4 chr15:75952905-75952925 1.41e-01 20 chr13:21596391-21596411 6.14e-07 [+5(4.68e-05)]_[+1(3.42e-05)]_4 chr1:2303672-2303692 2.30e-05 2_[+2(1.37e-05)]_10 chr6:37602204-37602224 8.30e-01 20 chr10:21503460-21503480 7.58e-05 2_[+2(5.76e-05)]_10 chr5:10538378-10538398 1.12e-04 20 chr8:143381036-143381056 7.12e-05 20 chr16:4740577-4740597 1.60e-03 20 chr2:27342078-27342098 5.70e-02 20 chr7:154415306-154415326 1.28e-05 7_[+3(1.57e-05)]_5 chr8:10427804-10427824 2.94e-04 4_[+2(1.37e-05)]_8 chr19:46171033-46171053 2.23e-02 20 chr17:19649990-19650010 3.23e-06 8_[+1(1.63e-05)]_4 chr17:72541449-72541469 2.80e-07 4_[+5(1.56e-05)]_8 chr19:47947887-47947907 3.38e-01 20 chr19:4543063-4543083 1.33e-02 20 chr12:804457-804477 2.51e-06 7_[+1(3.42e-05)]_5 chr16:86107897-86107917 2.12e-04 20 chr5:148772545-148772565 4.57e-06 8_[+1(1.63e-05)]_4 chr3:16246436-16246456 7.26e-04 20 chr5:172179316-172179336 1.35e-03 9_[+1(1.63e-05)]_3 chr11:68118438-68118458 5.58e-03 2_[+1(6.43e-05)]_10 chr9:36843062-36843082 1.96e-04 5_[+1(1.63e-05)]_7 chr19:48616676-48616696 4.69e-01 20 chr13:111288725-11128874 1.75e-04 [+2(5.76e-05)]_12 chr2:65253963-65253983 8.78e-01 20 chr21:46529148-46529168 9.24e-06 2_[+1(1.63e-05)]_10 chr1:25190744-25190764 8.87e-06 7_[+5(1.56e-05)]_5 chr3:9556179-9556199 5.52e-01 20 chr12:125000206-12500022 8.57e-05 1_[+5(1.56e-05)]_11 chr16:30907092-30907112 7.91e-05 11_[+3(1.57e-05)]_1 chr14:35832204-35832224 9.97e-06 [+2(2.94e-05)]_12 chr15:57612491-57612511 1.79e-04 20 chr21:46408362-46408382 7.23e-08 [+5(1.56e-05)]_[+5(1.56e-05)]_4 chrX:73765908-73765928 5.57e-01 20 chr17:77995679-77995699 1.98e-03 10_[+3(6.51e-05)]_2 chr17:79943001-79943021 3.00e-06 3_[+2(1.37e-05)]_9 chr9:138899340-138899360 2.02e-04 20 chr20:23425673-23425693 1.55e-02 20 chr12:125023764-12502378 3.26e-03 20 chr2:241440627-241440647 9.91e-05 20 chr1:3608549-3608569 2.06e-05 [+5(1.56e-05)]_12 chr10:127817383-12781740 8.30e-05 8_[+1(6.43e-05)]_4 chr14:105223011-10522303 2.78e-02 20 chr1:1165306-1165326 7.34e-04 20 chr2:112918273-112918293 6.14e-06 [+3(3.38e-05)]_[+2(1.37e-05)]_4 chrX:152705588-152705608 5.77e-03 1_[+1(6.43e-05)]_11 chr19:1642250-1642270 4.35e-06 7_[+3(1.57e-05)]_5 chr21:43488844-43488864 7.13e-03 20 chr1:226837196-226837216 6.51e-05 20 chr17:35013884-35013904 8.83e-05 1_[+3(4.98e-05)]_2_[+3(6.51e-05)]_1 chr17:982443-982463 1.37e-03 20 chr6:29949272-29949292 1.51e-02 20 chr4:8375162-8375182 2.69e-02 20 chr20:61967881-61967901 8.90e-06 6_[+1(3.42e-05)]_6 chr19:1417282-1417302 9.87e-01 20 chr1:55545515-55545535 1.69e-03 20 chr1:40421413-40421433 8.75e-01 20 chr4:1331196-1331216 1.98e-02 20 chr17:78264186-78264206 8.24e-05 20 chr19:39648800-39648820 3.13e-04 1_[+5(7.44e-05)]_[+1(6.43e-05)]_3 chr19:3831018-3831038 1.55e-05 20 chr8:81871503-81871523 6.75e-08 7_[+5(1.56e-05)]_5 chr19:46461821-46461841 1.13e-03 8_[+1(6.43e-05)]_4 chr10:23437301-23437321 4.59e-06 2_[+1(3.42e-05)]_2_[+1(3.42e-05)] chr9:34652379-34652399 3.84e-01 20 chr12:124338404-12433842 3.33e-05 3_[+2(1.37e-05)]_9 chr19:7972259-7972279 5.25e-02 20 chr16:70974041-70974061 5.03e-01 20 chr20:44845893-44845913 1.35e-01 20 chr10:134807189-13480720 1.11e-01 20 chr19:28565866-28565886 8.00e-01 20 chr17:35174387-35174407 7.23e-08 2_[+1(1.63e-05)]_2_[+5(1.56e-05)] chr16:31343249-31343269 1.14e-05 11_[+4(3.27e-05)]_1 chr5:149643046-149643066 2.38e-03 10_[+2(7.15e-05)]_2 chr12:1925990-1926010 6.52e-05 12_[+2(2.94e-05)] chr15:41206410-41206430 5.16e-03 3_[+1(6.43e-05)]_9 chr8:130564397-130564417 4.67e-01 20 chr17:65050991-65051011 2.91e-04 20 chr17:3593174-3593194 5.94e-05 [+2(1.37e-05)]_12 chr11:2310186-2310206 1.77e-03 1_[+2(5.76e-05)]_11 chr20:56371365-56371385 1.38e-03 9_[+1(1.63e-05)]_3 chr3:54751760-54751780 8.93e-05 1_[+5(1.56e-05)]_11 chr17:62077162-62077182 1.46e-06 3_[+1(3.42e-05)]_9 chr2:3467936-3467956 2.00e-03 7_[+2(5.76e-05)]_5 chr19:47140582-47140602 3.99e-06 5_[+2(1.37e-05)]_7 chr17:74273775-74273795 3.58e-06 6_[+2(1.37e-05)]_6 chr13:111107980-11110800 8.48e-02 20 chr17:21247819-21247839 5.93e-03 20 chr11:47377416-47377436 4.95e-03 3_[+2(8.54e-05)]_9 chr2:240212363-240212383 2.22e-03 20 chr21:43339263-43339283 2.58e-04 12_[+1(1.63e-05)] chr9:96411998-96412018 1.64e-04 20 chr5:1502024-1502044 9.67e-01 20 chr18:13590056-13590076 2.06e-05 4_[+5(1.56e-05)]_8 chr18:28565913-28565933 9.64e-07 5_[+1(1.63e-05)]_7 chr9:127155209-127155229 7.87e-01 20 chr19:1389203-1389223 4.52e-03 9_[+2(5.76e-05)]_3 chr13:113773888-11377390 1.03e-04 11_[+2(1.37e-05)]_1 chr2:127801345-127801365 1.05e-05 4_[+2(2.94e-05)]_8 chr17:80005323-80005343 1.06e-04 9_[+3(6.51e-05)]_3 chr16:57985298-57985318 4.83e-01 20 chr22:25779996-25780016 4.39e-02 20 chr16:88959743-88959763 6.12e-04 9_[+5(3.32e-05)]_3 chr12:22174321-22174341 2.09e-01 20 chr1:25297620-25297640 1.83e-07 1_[+1(4.83e-05)]_[+5(1.56e-05)]_3 chr10:134775407-13477542 2.69e-04 20 chr13:100555643-10055566 3.25e-04 5_[+2(1.37e-05)]_7 chr12:54944138-54944158 4.41e-04 12_[+1(1.63e-05)] chr19:3808160-3808180 1.92e-04 1_[+1(1.63e-05)]_11 chr2:240428879-240428899 2.12e-05 8_[+2(5.76e-05)]_4 chr14:99850179-99850199 3.81e-05 1_[+3(1.57e-05)]_2_[+3(6.51e-05)]_1 chr1:228122717-228122737 9.30e-01 20 chr19:19097906-19097926 5.98e-08 5_[+5(1.56e-05)]_7 chr2:241288762-241288782 9.49e-06 20 chr11:123421128-12342114 2.01e-04 11_[+2(7.15e-05)]_1 chr1:30216290-30216310 1.52e-02 20 chr12:125161493-12516151 6.10e-05 7_[+1(4.83e-05)]_5 chr16:25645045-25645065 5.66e-01 20 chr17:79122590-79122610 3.11e-06 10_[+2(7.15e-05)]_2 chr13:114497782-11449780 4.94e-07 6_[+1(1.63e-05)]_6 chr9:34653237-34653257 3.65e-02 20 chr12:114290710-11429073 9.04e-01 20 chr3:195614751-195614771 9.21e-07 20 chr2:765526-765546 7.08e-02 20 chr10:99685481-99685501 3.58e-02 20 chr12:124818497-12481851 9.00e-06 3_[+1(1.63e-05)]_9 chr12:9514798-9514818 2.47e-01 20 chr12:10696302-10696322 1.65e-02 20 chr1:2280269-2280289 1.50e-04 1_[+2(2.94e-05)]_11 chr7:155137374-155137394 4.12e-01 20 chr11:68616091-68616111 7.90e-06 1_[+2(2.94e-05)]_2_[+3(1.57e-05)]_1 chr5:152860164-152860184 8.13e-01 20 chr17:78198077-78198097 9.17e-04 5_[+1(6.43e-05)]_7 chr16:29679266-29679286 9.62e-06 1_[+1(1.63e-05)]_2_[+4(3.27e-05)]_1 chr6:166121131-166121151 3.57e-02 20 chr19:42409629-42409649 6.90e-06 4_[+1(1.63e-05)]_8 chr2:26784872-26784892 9.33e-06 6_[+3(3.38e-05)]_6 chr22:44542108-44542128 2.15e-05 6_[+3(1.57e-05)]_6 chr8:144636691-144636711 5.41e-05 20 chr6:37537282-37537302 3.76e-05 7_[+1(1.63e-05)]_5 chr5:14438517-14438537 5.73e-01 20 chr8:29949364-29949384 4.87e-06 6_[+2(1.37e-05)]_6 chr18:77943738-77943758 5.39e-02 20 chr14:61906298-61906318 7.29e-01 20 chr17:7013056-7013076 1.26e-03 7_[+2(7.15e-05)]_5 chr14:77624850-77624870 6.89e-04 8_[+2(1.37e-05)]_4 chr18:77557592-77557612 2.95e-06 3_[+1(1.63e-05)]_9 chr12:131148945-13114896 6.45e-06 3_[+3(3.38e-05)]_[+2(1.37e-05)]_1 chr22:36029736-36029756 4.85e-06 4_[+1(1.63e-05)]_8 chr20:61168318-61168338 3.91e-04 20 chr6:28105524-28105544 8.29e-01 20 chr8:134820664-134820684 2.73e-06 3_[+1(1.63e-05)]_9 chr11:65577990-65578010 6.74e-05 2_[+3(4.98e-05)]_[+2(1.37e-05)]_2 chr21:46730071-46730091 1.85e-03 7_[+2(5.76e-05)]_5 chr7:98674458-98674478 6.13e-07 6_[+1(1.63e-05)]_6 chr10:1568002-1568022 2.98e-05 20 chr13:46698793-46698813 3.17e-01 20 chr12:48338646-48338666 1.24e-06 2_[+2(1.37e-05)]_10 chr3:98332049-98332069 1.02e-01 20 chr2:9606474-9606494 2.54e-06 7_[+2(1.37e-05)]_5 chr11:78777735-78777755 3.99e-06 8_[+2(1.37e-05)]_4 chr17:76694221-76694241 8.88e-06 [+3(3.38e-05)]_12 chr12:24872562-24872582 7.99e-01 20 chr1:3563397-3563417 9.71e-01 20 chr8:58162275-58162295 1.61e-02 7_[+1(6.43e-05)]_5 chr5:171651109-171651129 9.26e-01 20 chr17:79131166-79131186 1.69e-03 20 chr16:1777295-1777315 6.13e-03 6_[+1(6.43e-05)]_6 chr8:142244187-142244207 9.94e-01 20 chr2:235209765-235209785 1.43e-06 2_[+2(7.15e-05)]_2_[+4(9.73e-05)] chr9:129946683-129946703 2.51e-03 20 chr10:14013137-14013157 1.96e-07 1_[+2(1.37e-05)]_[+4(9.73e-05)]_3 chr17:80681438-80681458 7.23e-08 9_[+5(1.56e-05)]_3 chr22:29607626-29607646 4.44e-07 3_[+5(1.56e-05)]_9 chr9:88861866-88861886 7.24e-01 20 chr8:52307625-52307645 7.38e-01 20 chr15:79744728-79744748 2.69e-01 20 chr14:35822280-35822300 1.79e-05 10_[+2(1.37e-05)]_2 chr14:54349507-54349527 7.05e-01 20 chr22:39157920-39157940 6.16e-06 5_[+1(1.63e-05)]_7 chr17:75800029-75800049 4.87e-06 20 chr16:28050983-28051003 6.59e-07 3_[+3(1.57e-05)]_9 chr17:75869181-75869201 5.05e-06 3_[+3(1.57e-05)]_[+2(1.37e-05)]_1 chr12:120683064-12068308 9.87e-01 20 chr1:23039058-23039078 4.21e-01 20 chr11:61301909-61301929 6.45e-06 8_[+3(1.57e-05)]_4 chr19:35888147-35888167 3.23e-01 20 chr6:97345778-97345798 3.43e-01 20 chr2:241165275-241165295 8.97e-01 20 chr1:22896788-22896808 4.24e-06 20 chr8:6604172-6604192 6.21e-04 20 chr10:1148102-1148122 9.42e-02 20 chr3:189815007-189815027 2.62e-01 20 chr11:123121879-12312189 2.68e-06 4_[+5(1.56e-05)]_8 chr4:146444442-146444462 1.63e-02 20 chr7:129950054-129950074 4.48e-02 20 chr17:62932453-62932473 1.00e-02 20 chr20:62478602-62478622 2.80e-04 7_[+2(1.37e-05)]_5 chr15:67225088-67225108 8.90e-09 [+2(8.54e-05)]_[+5(4.68e-05)]_4 chr14:99787812-99787832 1.09e-04 2_[+2(1.37e-05)]_10 chr17:81028883-81028903 1.56e-04 11_[+2(2.94e-05)]_1 chr12:3215012-3215032 1.45e-05 [+3(1.57e-05)]_2_[+2(1.37e-05)]_2 chr12:66466567-66466587 9.62e-03 20 chr4:186228436-186228456 9.96e-01 20 chr10:3441725-3441745 4.82e-09 3_[+1(3.42e-05)]_9 chr4:38787784-38787804 9.09e-01 20 chr2:121035620-121035640 8.82e-04 3_[+5(7.44e-05)]_9 chr7:151587269-151587289 1.51e-04 20 chr1:42611896-42611916 3.28e-02 20 chr17:78913161-78913181 3.51e-06 12_[+3(1.57e-05)] chr17:16311551-16311571 2.11e-03 20 chr14:105058844-10505886 2.01e-04 5_[+2(7.15e-05)]_7 chr2:10156280-10156300 1.19e-04 20 chrX:148280958-148280978 6.29e-01 20 chr8:135585074-135585094 8.01e-01 20 chr9:132754501-132754521 9.17e-03 20 chr6:24933688-24933708 7.52e-01 20 chr11:64463175-64463195 4.70e-02 20 chr9:136657609-136657629 2.59e-01 20 chr19:35909174-35909194 9.84e-01 20 chr21:43813476-43813496 7.80e-01 20 chr8:135612653-135612673 7.73e-01 20 chr3:99137170-99137190 3.58e-01 20 chr19:39820055-39820075 4.64e-04 5_[+2(1.37e-05)]_7 chr3:4796157-4796177 7.16e-01 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c17n09.farnam.hpc.yale.internal ********************************************************************************