******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/BATF.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr1:7278493-7278513 1.0000 20 chr8:134165344-134165364 1.0000 20 chr2:216910030-216910050 1.0000 20 chr4:187055606-187055626 1.0000 20 chr11:115456286-11545630 1.0000 20 chr8:26105972-26105992 1.0000 20 chr2:47137042-47137062 1.0000 20 chr12:105134692-10513471 1.0000 20 chr1:205309048-205309068 1.0000 20 chr7:37758892-37758912 1.0000 20 chr1:205569456-205569476 1.0000 20 chr4:185339237-185339257 1.0000 20 chr3:122252858-122252878 1.0000 20 chr14:68147020-68147040 1.0000 20 chr6:14666315-14666335 1.0000 20 chr15:101679285-10167930 1.0000 20 chr11:102239379-10223939 1.0000 20 chr5:172117439-172117459 1.0000 20 chr3:197588304-197588324 1.0000 20 chr9:109935364-109935384 1.0000 20 chr17:25566257-25566277 1.0000 20 chr10:6178435-6178455 1.0000 20 chr1:101001724-101001744 1.0000 20 chr2:227849559-227849579 1.0000 20 chr4:113249228-113249248 1.0000 20 chr10:17274496-17274516 1.0000 20 chr12:96896512-96896532 1.0000 20 chr10:101934660-10193468 1.0000 20 chr14:93029913-93029933 1.0000 20 chr7:139912487-139912507 1.0000 20 chr18:13019461-13019481 1.0000 20 chr18:10838790-10838810 1.0000 20 chr11:123173602-12317362 1.0000 20 chr4:62648922-62648942 1.0000 20 chr11:4721118-4721138 1.0000 20 chr9:138998444-138998464 1.0000 20 chr2:98583564-98583584 1.0000 20 chr22:26145920-26145940 1.0000 20 chr10:35630610-35630630 1.0000 20 chr9:97658178-97658198 1.0000 20 chr5:116032261-116032281 1.0000 20 chr3:127481563-127481583 1.0000 20 chr19:19521771-19521791 1.0000 20 chr9:126080668-126080688 1.0000 20 chr5:114796279-114796299 1.0000 20 chr3:155213419-155213439 1.0000 20 chr5:167676232-167676252 1.0000 20 chr11:87913314-87913334 1.0000 20 chr10:98348965-98348985 1.0000 20 chr3:124295548-124295568 1.0000 20 chr3:144014187-144014207 1.0000 20 chr17:68133684-68133704 1.0000 20 chr2:12641783-12641803 1.0000 20 chr15:90752997-90753017 1.0000 20 chr3:138232511-138232531 1.0000 20 chr5:150831504-150831524 1.0000 20 chr7:7298141-7298161 1.0000 20 chr2:20565320-20565340 1.0000 20 chr5:99501210-99501230 1.0000 20 chr7:75224329-75224349 1.0000 20 chr9:95853888-95853908 1.0000 20 chr17:48360762-48360782 1.0000 20 chr6:148941918-148941938 1.0000 20 chr15:79965942-79965962 1.0000 20 chr8:8807490-8807510 1.0000 20 chr6:68836421-68836441 1.0000 20 chr12:68513622-68513642 1.0000 20 chr2:111926243-111926263 1.0000 20 chr4:103456716-103456736 1.0000 20 chr17:78232786-78232806 1.0000 20 chr12:68104493-68104513 1.0000 20 chr12:65054551-65054571 1.0000 20 chr2:225822456-225822476 1.0000 20 chr10:124052876-12405289 1.0000 20 chr4:105887966-105887986 1.0000 20 chr9:100062278-100062298 1.0000 20 chr12:108967285-10896730 1.0000 20 chr19:33726617-33726637 1.0000 20 chr17:64028644-64028664 1.0000 20 chr2:20716894-20716914 1.0000 20 chr9:1536685-1536705 1.0000 20 chr2:204736418-204736438 1.0000 20 chr10:126303066-12630308 1.0000 20 chr3:113962013-113962033 1.0000 20 chr1:113574073-113574093 1.0000 20 chr19:36202394-36202414 1.0000 20 chr2:10054941-10054961 1.0000 20 chr15:57079328-57079348 1.0000 20 chr18:21826310-21826330 1.0000 20 chr1:167632335-167632355 1.0000 20 chr1:28624519-28624539 1.0000 20 chr18:77467860-77467880 1.0000 20 chrX:71569231-71569251 1.0000 20 chr20:3400955-3400975 1.0000 20 chr3:34112532-34112552 1.0000 20 chr8:64314658-64314678 1.0000 20 chr6:73450048-73450068 1.0000 20 chr5:78281581-78281601 1.0000 20 chr9:102574134-102574154 1.0000 20 chr2:175257622-175257642 1.0000 20 chr17:8842947-8842967 1.0000 20 chr15:74834347-74834367 1.0000 20 chr18:42289907-42289927 1.0000 20 chr16:29655812-29655832 1.0000 20 chr4:37893441-37893461 1.0000 20 chr4:24858298-24858318 1.0000 20 chr5:55273988-55274008 1.0000 20 chr16:80614581-80614601 1.0000 20 chr5:123919621-123919641 1.0000 20 chr1:32332148-32332168 1.0000 20 chr9:5510502-5510522 1.0000 20 chr18:13375424-13375444 1.0000 20 chr11:10548942-10548962 1.0000 20 chr5:130731844-130731864 1.0000 20 chr20:30866320-30866340 1.0000 20 chr3:45926524-45926544 1.0000 20 chr3:112770269-112770289 1.0000 20 chr3:125819669-125819689 1.0000 20 chr2:65214578-65214598 1.0000 20 chr20:19928705-19928725 1.0000 20 chr1:243751669-243751689 1.0000 20 chr17:79218863-79218883 1.0000 20 chr11:70170670-70170690 1.0000 20 chr6:90790737-90790757 1.0000 20 chr3:29725348-29725368 1.0000 20 chr1:159091919-159091939 1.0000 20 chr11:72064421-72064441 1.0000 20 chr11:66659811-66659831 1.0000 20 chr15:59661997-59662017 1.0000 20 chr9:134882593-134882613 1.0000 20 chr5:52063789-52063809 1.0000 20 chr8:42046618-42046638 1.0000 20 chr6:158221809-158221829 1.0000 20 chr2:208021780-208021800 1.0000 20 chr10:120458164-12045818 1.0000 20 chr11:128627948-12862796 1.0000 20 chr5:176791746-176791766 1.0000 20 chr5:156543572-156543592 1.0000 20 chr11:48028396-48028416 1.0000 20 chr12:105324607-10532462 1.0000 20 chr4:146950482-146950502 1.0000 20 chr5:144436564-144436584 1.0000 20 chr13:32505237-32505257 1.0000 20 chr15:36222114-36222134 1.0000 20 chr7:105406939-105406959 1.0000 20 chr2:111858579-111858599 1.0000 20 chr8:94966974-94966994 1.0000 20 chr10:10911762-10911782 1.0000 20 chr6:130544784-130544804 1.0000 20 chr2:20725229-20725249 1.0000 20 chr8:37595310-37595330 1.0000 20 chr6:73359500-73359520 1.0000 20 chr8:54798657-54798677 1.0000 20 chr2:146506723-146506743 1.0000 20 chr12:124611708-12461172 1.0000 20 chr2:191587399-191587419 1.0000 20 chr10:81026651-81026671 1.0000 20 chr10:329949-329969 1.0000 20 chr2:149361339-149361359 1.0000 20 chr12:104856868-10485688 1.0000 20 chr4:25125052-25125072 1.0000 20 chr5:123860442-123860462 1.0000 20 chr3:159579609-159579629 1.0000 20 chr6:155095135-155095155 1.0000 20 chr3:11862113-11862133 1.0000 20 chr9:117457302-117457322 1.0000 20 chr16:23304523-23304543 1.0000 20 chr13:50941114-50941134 1.0000 20 chr6:15876905-15876925 1.0000 20 chr11:64099445-64099465 1.0000 20 chr21:36423049-36423069 1.0000 20 chr5:171416411-171416431 1.0000 20 chr21:39621348-39621368 1.0000 20 chr9:33988643-33988663 1.0000 20 chr5:17343978-17343998 1.0000 20 chr4:56484181-56484201 1.0000 20 chr9:136001487-136001507 1.0000 20 chr10:32438225-32438245 1.0000 20 chr7:7805252-7805272 1.0000 20 chr4:89449067-89449087 1.0000 20 chr16:48222580-48222600 1.0000 20 chr8:126315437-126315457 1.0000 20 chr19:39842329-39842349 1.0000 20 chr12:92172802-92172822 1.0000 20 chr4:145277688-145277708 1.0000 20 chr11:102482223-10248224 1.0000 20 chr1:198143686-198143706 1.0000 20 chr18:650547-650567 1.0000 20 chr1:249088002-249088022 1.0000 20 chr13:50798832-50798852 1.0000 20 chr14:70142959-70142979 1.0000 20 chr15:48106424-48106444 1.0000 20 chr8:131457220-131457240 1.0000 20 chr5:33934128-33934148 1.0000 20 chr1:63087844-63087864 1.0000 20 chrX:62975957-62975977 1.0000 20 chr11:108094757-10809477 1.0000 20 chr1:200849608-200849628 1.0000 20 chr15:57833094-57833114 1.0000 20 chr10:74397361-74397381 1.0000 20 chr3:56787414-56787434 1.0000 20 chr3:114598310-114598330 1.0000 20 chr4:36653068-36653088 1.0000 20 chr3:186228293-186228313 1.0000 20 chr11:133847075-13384709 1.0000 20 chr1:206942960-206942980 1.0000 20 chr6:111809034-111809054 1.0000 20 chr22:45650985-45651005 1.0000 20 chr10:27026885-27026905 1.0000 20 chr22:28291759-28291779 1.0000 20 chr18:74775384-74775404 1.0000 20 chr21:43422723-43422743 1.0000 20 chr15:60211725-60211745 1.0000 20 chr2:100752953-100752973 1.0000 20 chr2:230865361-230865381 1.0000 20 chr1:213151256-213151276 1.0000 20 chr5:54198792-54198812 1.0000 20 chr5:169083269-169083289 1.0000 20 chr7:41771741-41771761 1.0000 20 chr9:113388923-113388943 1.0000 20 chr18:53779801-53779821 1.0000 20 chr2:12434196-12434216 1.0000 20 chr1:198638368-198638388 1.0000 20 chr8:38401229-38401249 1.0000 20 chr8:124560667-124560687 1.0000 20 chr5:60122678-60122698 1.0000 20 chr12:122430305-12243032 1.0000 20 chr12:18318667-18318687 1.0000 20 chr6:158897055-158897075 1.0000 20 chr8:84860641-84860661 1.0000 20 chr12:123478187-12347820 1.0000 20 chr17:63653085-63653105 1.0000 20 chrX:96294876-96294896 1.0000 20 chr2:213595938-213595958 1.0000 20 chr11:95846123-95846143 1.0000 20 chr11:83324661-83324681 1.0000 20 chr12:919999-920019 1.0000 20 chr19:10987536-10987556 1.0000 20 chr9:123980338-123980358 1.0000 20 chr2:216782997-216783017 1.0000 20 chr12:94699488-94699508 1.0000 20 chr12:66150847-66150867 1.0000 20 chr1:234033246-234033266 1.0000 20 chr1:219638776-219638796 1.0000 20 chr3:150502327-150502347 1.0000 20 chr2:48475897-48475917 1.0000 20 chr11:43575526-43575546 1.0000 20 chr10:79805203-79805223 1.0000 20 chr20:1612982-1613002 1.0000 20 chr11:125860255-12586027 1.0000 20 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/GM12878/inference_raw/MEME/RankLinear0.6_10_BATF/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/GM12878/fasta/RankLinear0.6_10/BATF.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 5000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 5000 norand= no csites= 1000 Letter frequencies in dataset: A 0.289 C 0.207 G 0.213 T 0.29 Background letter frequencies (from file dataset with add-one prior applied): A 0.289 C 0.207 G 0.213 T 0.29 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF TGASTCAT MEME-1 width = 8 sites = 81 llr = 577 E-value = 6.0e-073 ******************************************************************************** -------------------------------------------------------------------------------- Motif TGASTCAT MEME-1 Description -------------------------------------------------------------------------------- Simplified A 1:a::1a2 pos.-specific C :1:5:9:1 probability G :8:5:::1 matrix T 91::a::6 bits 2.3 2.0 1.8 * 1.6 *** Relative 1.4 ** *** Entropy 1.1 *** *** (10.3 bits) 0.9 ******* 0.7 ******* 0.5 ******** 0.2 ******** 0.0 -------- Multilevel TGAGTCAT consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAT MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr8:124560667-124560687 8 3.77e-05 CGTTTTC TGAGTCAT TTAAG chr2:12434196-12434216 1 3.77e-05 . TGAGTCAT TGTGTGAAAA chr3:11862113-11862133 3 3.77e-05 TA TGACTCAT TTCTTCAGAA chr2:149361339-149361359 3 3.77e-05 AG TGAGTCAT AGAGAAACTG chr10:10911762-10911782 13 3.77e-05 AAACCGGCCA TGAGTCAT chr2:111858579-111858599 9 3.77e-05 TTGATTGA TGAGTCAT TCAA chr20:19928705-19928725 8 3.77e-05 CTCCAGA TGACTCAT GTAAG chr3:112770269-112770289 5 3.77e-05 TAAA TGAGTCAT TCTGGCTT chr16:80614581-80614601 10 3.77e-05 GTTTTGAAA TGACTCAT CCA chr15:74834347-74834367 2 3.77e-05 C TGAGTCAT CTCAGTCTTA chr2:175257622-175257642 11 3.77e-05 actgcagatt tgagtcat ga chr6:73450048-73450068 6 3.77e-05 AAGTC TGAGTCAT TTTGAGA chr19:36202394-36202414 1 3.77e-05 . TGACTCAT CTTCCCCTCT chr4:103456716-103456736 3 3.77e-05 GA TGACTCAT TTTAAGCAAA chr5:150831504-150831524 5 3.77e-05 gatt tgactcat cctggggc chr3:138232511-138232531 3 3.77e-05 tt tgactcat tggcctaacc chr11:87913314-87913334 11 3.77e-05 ACTTGCAATT TGAGTCAT CT chr11:4721118-4721138 4 3.77e-05 ATT TGAGTCAT CTACACCCA chr4:62648922-62648942 9 3.77e-05 GGATTCTG TGACTCAT TTTG chr4:185339237-185339257 4 3.77e-05 CTG TGACTCAT CTTTACAAG chr1:205309048-205309068 6 3.77e-05 CAGAG TGAGTCAT ATCTGTA chr2:47137042-47137062 12 3.77e-05 GGTTTCAGAA TGACTCAT C chr8:26105972-26105992 13 3.77e-05 ctgccctttg tgactcat chr8:134165344-134165364 1 3.77e-05 . TGACTCAT TCCGAAAGCG chr3:159579609-159579629 12 6.54e-05 AGTGGTGTTT TGAGTCAG C chr15:36222114-36222134 8 6.54e-05 TTCTTTT TGAGTCAG CAAGC chr1:28624519-28624539 9 6.54e-05 tttgaagg tgagtcag aTTG chr12:65054551-65054571 4 6.54e-05 CTT TGAGTCAG AAGCAAGCT chr2:111926243-111926263 7 6.54e-05 CAGATA TGACTCAG CACTTG chr12:92172802-92172822 1 1.03e-04 . TGACTCAA GAATGATAAA chr4:25125052-25125072 4 1.03e-04 TTT TGAGTCAA AACGAAAGT chr6:130544784-130544804 8 1.03e-04 TGCAGTG TGACTCAA AGTGA chr8:42046618-42046638 6 1.03e-04 GAGTA TGACTCAA AATGAAA chr4:24858298-24858318 11 1.03e-04 AGTCGAGAGA TGACTCAA TT chr18:42289907-42289927 1 1.03e-04 . TGACTCAA AATGAAAGTT chr17:68133684-68133704 10 1.03e-04 ACAAAGCCC TGACTCAA TTC chr3:122252858-122252878 4 1.03e-04 aga tgagtcaa ttggtgcag chr9:123980338-123980358 5 1.68e-04 GCCC TGACTCAC AGTTTAGC chr5:176791746-176791766 1 1.68e-04 . AGAGTCAT TTTGAGAGGA chr10:120458164-12045818 8 1.68e-04 acgtgaa tgagtcac actga chr15:59661997-59662017 3 1.68e-04 TA TGAGTCAC AACTGAATGA chr2:65214578-65214598 5 1.68e-04 ccga agactcat ttctggag chr6:68836421-68836441 6 1.68e-04 tgaat tgagtcac atctctg chr2:98583564-98583584 4 1.68e-04 TTT TGACTCAC CATAAAAGG chr16:48222580-48222600 9 2.19e-04 tctgtaac ttactcat tacg chr5:130731844-130731864 4 2.19e-04 AAA TTACTCAT CTTCATCTG chr5:55273988-55274008 4 2.19e-04 gta ttactcat aacagtagt chr10:79805203-79805223 5 3.08e-04 TAGA TGAGTAAT TCCGAAAC chr1:198638368-198638388 1 3.08e-04 . TGACTAAT GCTTAGTGTT chr9:113388923-113388943 11 3.08e-04 ctggaaccgg tgagtaat aa chr21:43422723-43422743 6 3.08e-04 CATTA TGAGTAAT CAGGGCC chr12:105324607-10532462 3 3.08e-04 GA TCAGTCAT CTCGCAGAAT chr2:10054941-10054961 11 3.08e-04 GAGTCACTGC TGAGTAAT AT chr1:205569456-205569476 13 3.34e-04 GCTCTCAGAA TGAATCAT chr9:33988643-33988663 4 3.62e-04 AAG GGAGTCAT CACACTACA chr10:124052876-12405289 4 3.62e-04 TGG GGACTCAT GAAATGACT chr7:75224329-75224349 4 3.62e-04 GAA GGACTCAT CTCAGGTAG chr1:113574073-113574093 4 4.00e-04 GCC TGTGTCAT AGTGAAAGA chr6:158221809-158221829 8 5.03e-04 CTCAGTC TTACTCAG ATGCT chr4:56484181-56484201 11 6.19e-04 ACTTTCCATT TGAGTAAG CA chr8:54798657-54798677 2 6.19e-04 G TCAGTCAG CAACTAATAG chr9:134882593-134882613 9 6.19e-04 TCTTATTG TTACTCAA ACCT chr3:29725348-29725368 7 6.19e-04 CAGGAA TGACTAAG CAGTTT chr15:90752997-90753017 13 6.19e-04 tgagtgtgag ttagtcaa chr21:36423049-36423069 10 7.08e-04 CTCCTGTTT TGACTAAA GCA chr1:213151256-213151276 1 7.27e-04 . TGAATCAG AATGGGAAAA chr9:102574134-102574154 5 7.27e-04 GAGA TGAATCAG TCTTGTTT chr8:94966974-94966994 4 8.07e-04 GGA TGGCTCAT ATTGGAAGA chr7:105406939-105406959 1 8.07e-04 . TGATTCAT TTCGGAATTT chr5:123919621-123919641 1 8.07e-04 . TGAATCAA CTAGAGAATG chr11:64099445-64099465 12 8.54e-04 AGTTTCTGAA TGACTCCT T chr12:123478187-12347820 1 1.03e-03 . tgacacat aatgggacca chr16:23304523-23304543 12 1.03e-03 gtgaacaccc atactcat a chr2:208021780-208021800 4 1.03e-03 GTC ATAGTCAT AACATGCTC chr11:108094757-10809477 12 1.21e-03 GACTTTCGAA ACAGTCAT A chr12:104856868-10485688 1 1.21e-03 . ACAGTCAT TTCAAAACAG chr9:138998444-138998464 10 1.21e-03 GCCCTTGGC ACAGTCAT TCA chr4:187055606-187055626 8 1.21e-03 CGAGAAC ACAGTCAT CCTGA chr2:225822456-225822476 8 1.25e-03 CTCTACA TGTCTCAA AACAC chr9:126080668-126080688 11 1.25e-03 cagtcagagc tgtgtcaa aa chr1:159091919-159091939 10 1.37e-03 GGAGAAAGT TTAGTAAT ATC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAT MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr8:124560667-124560687 3.8e-05 7_[+1]_5 chr2:12434196-12434216 3.8e-05 [+1]_12 chr3:11862113-11862133 3.8e-05 2_[+1]_10 chr2:149361339-149361359 3.8e-05 2_[+1]_10 chr10:10911762-10911782 3.8e-05 12_[+1] chr2:111858579-111858599 3.8e-05 8_[+1]_4 chr20:19928705-19928725 3.8e-05 7_[+1]_5 chr3:112770269-112770289 3.8e-05 4_[+1]_8 chr16:80614581-80614601 3.8e-05 9_[+1]_3 chr15:74834347-74834367 3.8e-05 1_[+1]_11 chr2:175257622-175257642 3.8e-05 10_[+1]_2 chr6:73450048-73450068 3.8e-05 5_[+1]_7 chr19:36202394-36202414 3.8e-05 [+1]_12 chr4:103456716-103456736 3.8e-05 2_[+1]_10 chr5:150831504-150831524 3.8e-05 4_[+1]_8 chr3:138232511-138232531 3.8e-05 2_[+1]_10 chr11:87913314-87913334 3.8e-05 10_[+1]_2 chr11:4721118-4721138 3.8e-05 3_[+1]_9 chr4:62648922-62648942 3.8e-05 8_[+1]_4 chr4:185339237-185339257 3.8e-05 3_[+1]_9 chr1:205309048-205309068 3.8e-05 5_[+1]_7 chr2:47137042-47137062 3.8e-05 11_[+1]_1 chr8:26105972-26105992 3.8e-05 12_[+1] chr8:134165344-134165364 3.8e-05 [+1]_12 chr3:159579609-159579629 6.5e-05 11_[+1]_1 chr15:36222114-36222134 6.5e-05 7_[+1]_5 chr1:28624519-28624539 6.5e-05 8_[+1]_4 chr12:65054551-65054571 6.5e-05 3_[+1]_9 chr2:111926243-111926263 6.5e-05 6_[+1]_6 chr12:92172802-92172822 0.0001 [+1]_12 chr4:25125052-25125072 0.0001 3_[+1]_9 chr6:130544784-130544804 0.0001 7_[+1]_5 chr8:42046618-42046638 0.0001 5_[+1]_7 chr4:24858298-24858318 0.0001 10_[+1]_2 chr18:42289907-42289927 0.0001 [+1]_12 chr17:68133684-68133704 0.0001 9_[+1]_3 chr3:122252858-122252878 0.0001 3_[+1]_9 chr9:123980338-123980358 0.00017 4_[+1]_8 chr5:176791746-176791766 0.00017 [+1]_12 chr10:120458164-12045818 0.00017 7_[+1]_5 chr15:59661997-59662017 0.00017 2_[+1]_10 chr2:65214578-65214598 0.00017 4_[+1]_8 chr6:68836421-68836441 0.00017 5_[+1]_7 chr2:98583564-98583584 0.00017 3_[+1]_9 chr16:48222580-48222600 0.00022 8_[+1]_4 chr5:130731844-130731864 0.00022 3_[+1]_9 chr5:55273988-55274008 0.00022 3_[+1]_9 chr10:79805203-79805223 0.00031 4_[+1]_8 chr1:198638368-198638388 0.00031 [+1]_12 chr9:113388923-113388943 0.00031 10_[+1]_2 chr21:43422723-43422743 0.00031 5_[+1]_7 chr12:105324607-10532462 0.00031 2_[+1]_10 chr2:10054941-10054961 0.00031 10_[+1]_2 chr1:205569456-205569476 0.00033 12_[+1] chr9:33988643-33988663 0.00036 3_[+1]_9 chr10:124052876-12405289 0.00036 3_[+1]_9 chr7:75224329-75224349 0.00036 3_[+1]_9 chr1:113574073-113574093 0.0004 3_[+1]_9 chr6:158221809-158221829 0.0005 7_[+1]_5 chr4:56484181-56484201 0.00062 10_[+1]_2 chr8:54798657-54798677 0.00062 1_[+1]_11 chr9:134882593-134882613 0.00062 8_[+1]_4 chr3:29725348-29725368 0.00062 6_[+1]_6 chr15:90752997-90753017 0.00062 12_[+1] chr21:36423049-36423069 0.00071 9_[+1]_3 chr1:213151256-213151276 0.00073 [+1]_12 chr9:102574134-102574154 0.00073 4_[+1]_8 chr8:94966974-94966994 0.00081 3_[+1]_9 chr7:105406939-105406959 0.00081 [+1]_12 chr5:123919621-123919641 0.00081 [+1]_12 chr11:64099445-64099465 0.00085 11_[+1]_1 chr12:123478187-12347820 0.001 [+1]_12 chr16:23304523-23304543 0.001 11_[+1]_1 chr2:208021780-208021800 0.001 3_[+1]_9 chr11:108094757-10809477 0.0012 11_[+1]_1 chr12:104856868-10485688 0.0012 [+1]_12 chr9:138998444-138998464 0.0012 9_[+1]_3 chr4:187055606-187055626 0.0012 7_[+1]_5 chr2:225822456-225822476 0.0013 7_[+1]_5 chr9:126080668-126080688 0.0013 10_[+1]_2 chr1:159091919-159091939 0.0014 9_[+1]_3 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAT MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TGASTCAT width=8 seqs=81 chr8:124560667-124560687 ( 8) TGAGTCAT 1 chr2:12434196-12434216 ( 1) TGAGTCAT 1 chr3:11862113-11862133 ( 3) TGACTCAT 1 chr2:149361339-149361359 ( 3) TGAGTCAT 1 chr10:10911762-10911782 ( 13) TGAGTCAT 1 chr2:111858579-111858599 ( 9) TGAGTCAT 1 chr20:19928705-19928725 ( 8) TGACTCAT 1 chr3:112770269-112770289 ( 5) TGAGTCAT 1 chr16:80614581-80614601 ( 10) TGACTCAT 1 chr15:74834347-74834367 ( 2) TGAGTCAT 1 chr2:175257622-175257642 ( 11) TGAGTCAT 1 chr6:73450048-73450068 ( 6) TGAGTCAT 1 chr19:36202394-36202414 ( 1) TGACTCAT 1 chr4:103456716-103456736 ( 3) TGACTCAT 1 chr5:150831504-150831524 ( 5) TGACTCAT 1 chr3:138232511-138232531 ( 3) TGACTCAT 1 chr11:87913314-87913334 ( 11) TGAGTCAT 1 chr11:4721118-4721138 ( 4) TGAGTCAT 1 chr4:62648922-62648942 ( 9) TGACTCAT 1 chr4:185339237-185339257 ( 4) TGACTCAT 1 chr1:205309048-205309068 ( 6) TGAGTCAT 1 chr2:47137042-47137062 ( 12) TGACTCAT 1 chr8:26105972-26105992 ( 13) TGACTCAT 1 chr8:134165344-134165364 ( 1) TGACTCAT 1 chr3:159579609-159579629 ( 12) TGAGTCAG 1 chr15:36222114-36222134 ( 8) TGAGTCAG 1 chr1:28624519-28624539 ( 9) TGAGTCAG 1 chr12:65054551-65054571 ( 4) TGAGTCAG 1 chr2:111926243-111926263 ( 7) TGACTCAG 1 chr12:92172802-92172822 ( 1) TGACTCAA 1 chr4:25125052-25125072 ( 4) TGAGTCAA 1 chr6:130544784-130544804 ( 8) TGACTCAA 1 chr8:42046618-42046638 ( 6) TGACTCAA 1 chr4:24858298-24858318 ( 11) TGACTCAA 1 chr18:42289907-42289927 ( 1) TGACTCAA 1 chr17:68133684-68133704 ( 10) TGACTCAA 1 chr3:122252858-122252878 ( 4) TGAGTCAA 1 chr9:123980338-123980358 ( 5) TGACTCAC 1 chr5:176791746-176791766 ( 1) AGAGTCAT 1 chr10:120458164-12045818 ( 8) TGAGTCAC 1 chr15:59661997-59662017 ( 3) TGAGTCAC 1 chr2:65214578-65214598 ( 5) AGACTCAT 1 chr6:68836421-68836441 ( 6) TGAGTCAC 1 chr2:98583564-98583584 ( 4) TGACTCAC 1 chr16:48222580-48222600 ( 9) TTACTCAT 1 chr5:130731844-130731864 ( 4) TTACTCAT 1 chr5:55273988-55274008 ( 4) TTACTCAT 1 chr10:79805203-79805223 ( 5) TGAGTAAT 1 chr1:198638368-198638388 ( 1) TGACTAAT 1 chr9:113388923-113388943 ( 11) TGAGTAAT 1 chr21:43422723-43422743 ( 6) TGAGTAAT 1 chr12:105324607-10532462 ( 3) TCAGTCAT 1 chr2:10054941-10054961 ( 11) TGAGTAAT 1 chr1:205569456-205569476 ( 13) TGAATCAT 1 chr9:33988643-33988663 ( 4) GGAGTCAT 1 chr10:124052876-12405289 ( 4) GGACTCAT 1 chr7:75224329-75224349 ( 4) GGACTCAT 1 chr1:113574073-113574093 ( 4) TGTGTCAT 1 chr6:158221809-158221829 ( 8) TTACTCAG 1 chr4:56484181-56484201 ( 11) TGAGTAAG 1 chr8:54798657-54798677 ( 2) TCAGTCAG 1 chr9:134882593-134882613 ( 9) TTACTCAA 1 chr3:29725348-29725368 ( 7) TGACTAAG 1 chr15:90752997-90753017 ( 13) TTAGTCAA 1 chr21:36423049-36423069 ( 10) TGACTAAA 1 chr1:213151256-213151276 ( 1) TGAATCAG 1 chr9:102574134-102574154 ( 5) TGAATCAG 1 chr8:94966974-94966994 ( 4) TGGCTCAT 1 chr7:105406939-105406959 ( 1) TGATTCAT 1 chr5:123919621-123919641 ( 1) TGAATCAA 1 chr11:64099445-64099465 ( 12) TGACTCCT 1 chr12:123478187-12347820 ( 1) TGACACAT 1 chr16:23304523-23304543 ( 12) ATACTCAT 1 chr2:208021780-208021800 ( 4) ATAGTCAT 1 chr11:108094757-10809477 ( 12) ACAGTCAT 1 chr12:104856868-10485688 ( 1) ACAGTCAT 1 chr9:138998444-138998464 ( 10) ACAGTCAT 1 chr4:187055606-187055626 ( 8) ACAGTCAT 1 chr2:225822456-225822476 ( 8) TGTCTCAA 1 chr9:126080668-126080688 ( 11) TGTGTCAA 1 chr1:159091919-159091939 ( 10) TTAGTAAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAT MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 6.26212 E= 6.0e-073 -155 -1298 -253 157 -1298 -149 193 -138 172 -1298 -411 -297 -255 114 117 -455 -454 -1298 -1298 177 -138 210 -1298 -1298 177 -407 -1298 -1298 -74 -175 -65 112 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAT MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 81 E= 6.0e-073 0.098765 0.000000 0.037037 0.864198 0.000000 0.074074 0.814815 0.111111 0.950617 0.000000 0.012346 0.037037 0.049383 0.456790 0.481481 0.012346 0.012346 0.000000 0.000000 0.987654 0.111111 0.888889 0.000000 0.000000 0.987654 0.012346 0.000000 0.000000 0.172840 0.061728 0.135802 0.629630 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TGASTCAT MEME-1 regular expression -------------------------------------------------------------------------------- TGA[GC]TCAT -------------------------------------------------------------------------------- Time 2.40 secs. ******************************************************************************** ******************************************************************************** MOTIF ATGACTGT MEME-2 width = 8 sites = 14 llr = 135 E-value = 6.3e-008 ******************************************************************************** -------------------------------------------------------------------------------- Motif ATGACTGT MEME-2 Description -------------------------------------------------------------------------------- Simplified A a::a::1: pos.-specific C :1::9::: probability G ::a:1:92 matrix T :9:::a:8 bits 2.3 * 2.0 * 1.8 * ***** 1.6 * ***** Relative 1.4 ******* Entropy 1.1 ******** (13.9 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel ATGACTGT consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATGACTGT MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr19:10987536-10987556 13 1.91e-05 CTTTCTGGAA ATGACTGT chr2:100752953-100752973 2 1.91e-05 T ATGACTGT CCTCATTCTT chr22:45650985-45651005 2 1.91e-05 t atgactgt aggctacaga chr11:72064421-72064441 8 1.91e-05 TGGCATT ATGACTGT AAGGA chr6:90790737-90790757 3 1.91e-05 AA ATGACTGT GCTGTGACAA chr17:8842947-8842967 12 1.91e-05 tgctactgat atgactgt g chr12:108967285-10896730 3 1.91e-05 ct atgactgt ACTTTCTCTA chr19:19521771-19521791 13 1.91e-05 GAGTACTGTT ATGACTGT chr6:148941918-148941938 1 3.32e-05 . ATGACTGG GTGAAGCTGA chr10:101934660-10193468 13 3.32e-05 CGCTATTTAA ATGACTGG chr11:115456286-11545630 10 3.32e-05 TGTCACCAA ATGACTGG GCA chr18:650547-650567 10 4.68e-05 gtagcaacc acgactgt act chr15:90752997-90753017 2 6.65e-05 g atgagtgt gagttagtca chr6:155095135-155095155 1 9.25e-05 . ATGACTAT AAACCACCCA -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATGACTGT MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr19:10987536-10987556 1.9e-05 12_[+2] chr2:100752953-100752973 1.9e-05 1_[+2]_11 chr22:45650985-45651005 1.9e-05 1_[+2]_11 chr11:72064421-72064441 1.9e-05 7_[+2]_5 chr6:90790737-90790757 1.9e-05 2_[+2]_10 chr17:8842947-8842967 1.9e-05 11_[+2]_1 chr12:108967285-10896730 1.9e-05 2_[+2]_10 chr19:19521771-19521791 1.9e-05 12_[+2] chr6:148941918-148941938 3.3e-05 [+2]_12 chr10:101934660-10193468 3.3e-05 12_[+2] chr11:115456286-11545630 3.3e-05 9_[+2]_3 chr18:650547-650567 4.7e-05 9_[+2]_3 chr15:90752997-90753017 6.7e-05 1_[+2]_11 chr6:155095135-155095155 9.2e-05 [+2]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATGACTGT MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ATGACTGT width=8 seqs=14 chr19:10987536-10987556 ( 13) ATGACTGT 1 chr2:100752953-100752973 ( 2) ATGACTGT 1 chr22:45650985-45651005 ( 2) ATGACTGT 1 chr11:72064421-72064441 ( 8) ATGACTGT 1 chr6:90790737-90790757 ( 3) ATGACTGT 1 chr17:8842947-8842967 ( 12) ATGACTGT 1 chr12:108967285-10896730 ( 3) ATGACTGT 1 chr19:19521771-19521791 ( 13) ATGACTGT 1 chr6:148941918-148941938 ( 1) ATGACTGG 1 chr10:101934660-10193468 ( 13) ATGACTGG 1 chr11:115456286-11545630 ( 10) ATGACTGG 1 chr18:650547-650567 ( 10) ACGACTGT 1 chr15:90752997-90753017 ( 2) ATGAGTGT 1 chr6:155095135-155095155 ( 1) ATGACTAT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATGACTGT MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.4605 E= 6.3e-008 179 -1045 -1045 -1045 -1045 -154 -1045 168 -1045 -1045 223 -1045 179 -1045 -1045 -1045 -1045 216 -158 -1045 -1045 -1045 -1045 178 -201 -1045 212 -1045 -1045 -1045 1 144 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATGACTGT MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 14 E= 6.3e-008 1.000000 0.000000 0.000000 0.000000 0.000000 0.071429 0.000000 0.928571 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.928571 0.071429 0.000000 0.000000 0.000000 0.000000 1.000000 0.071429 0.000000 0.928571 0.000000 0.000000 0.000000 0.214286 0.785714 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ATGACTGT MEME-2 regular expression -------------------------------------------------------------------------------- ATGACTG[TG] -------------------------------------------------------------------------------- Time 3.88 secs. ******************************************************************************** ******************************************************************************** MOTIF ARYGAAAG MEME-3 width = 8 sites = 11 llr = 98 E-value = 1.4e+001 ******************************************************************************** -------------------------------------------------------------------------------- Motif ARYGAAAG MEME-3 Description -------------------------------------------------------------------------------- Simplified A a5::aaa: pos.-specific C :14::::: probability G :3:a:::a matrix T :26::::: bits 2.3 * * 2.0 * * 1.8 * ***** 1.6 * ***** Relative 1.4 * ***** Entropy 1.1 * ***** (12.8 bits) 0.9 * ****** 0.7 * ****** 0.5 * ****** 0.2 ******** 0.0 -------- Multilevel AATGAAAG consensus GC sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARYGAAAG MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr18:42289907-42289927 9 2.65e-05 TGACTCAA AATGAAAG TTTC chr20:3400955-3400975 5 2.65e-05 TGAT AATGAAAG CTATAATT chr16:29655812-29655832 2 4.61e-05 g agtgaaag tgctaataat chr1:113574073-113574093 12 4.61e-05 CCTGTGTCAT AGTGAAAG A chr10:98348965-98348985 5 4.61e-05 tcat agtgaaag ctcagtca chr15:48106424-48106444 1 6.50e-05 . AACGAAAG TGCTCACTGA chr4:25125052-25125072 12 6.50e-05 TTTGAGTCAA AACGAAAG T chr11:70170670-70170690 8 6.50e-05 GTGTCAA AACGAAAG GACGA chr11:83324661-83324681 7 1.06e-04 ATTAAA ATTGAAAG TCATTT chr11:133847075-13384709 9 1.06e-04 AAAGCAGT ATTGAAAG CACA chr2:12641783-12641803 8 1.57e-04 GACTCAT ACCGAAAG CCGGG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARYGAAAG MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr18:42289907-42289927 2.7e-05 8_[+3]_4 chr20:3400955-3400975 2.7e-05 4_[+3]_8 chr16:29655812-29655832 4.6e-05 1_[+3]_11 chr1:113574073-113574093 4.6e-05 11_[+3]_1 chr10:98348965-98348985 4.6e-05 4_[+3]_8 chr15:48106424-48106444 6.5e-05 [+3]_12 chr4:25125052-25125072 6.5e-05 11_[+3]_1 chr11:70170670-70170690 6.5e-05 7_[+3]_5 chr11:83324661-83324681 0.00011 6_[+3]_6 chr11:133847075-13384709 0.00011 8_[+3]_4 chr2:12641783-12641803 0.00016 7_[+3]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARYGAAAG MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ARYGAAAG width=8 seqs=11 chr18:42289907-42289927 ( 9) AATGAAAG 1 chr20:3400955-3400975 ( 5) AATGAAAG 1 chr16:29655812-29655832 ( 2) AGTGAAAG 1 chr1:113574073-113574093 ( 12) AGTGAAAG 1 chr10:98348965-98348985 ( 5) AGTGAAAG 1 chr15:48106424-48106444 ( 1) AACGAAAG 1 chr4:25125052-25125072 ( 12) AACGAAAG 1 chr11:70170670-70170690 ( 8) AACGAAAG 1 chr11:83324661-83324681 ( 7) ATTGAAAG 1 chr11:133847075-13384709 ( 9) ATTGAAAG 1 chr2:12641783-12641803 ( 8) ACCGAAAG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARYGAAAG MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 7.75266 E= 1.4e+001 179 -1010 -1010 -1010 65 -119 35 -67 -1010 81 -1010 113 -1010 -1010 223 -1010 179 -1010 -1010 -1010 179 -1010 -1010 -1010 179 -1010 -1010 -1010 -1010 -1010 223 -1010 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARYGAAAG MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 11 E= 1.4e+001 1.000000 0.000000 0.000000 0.000000 0.454545 0.090909 0.272727 0.181818 0.000000 0.363636 0.000000 0.636364 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ARYGAAAG MEME-3 regular expression -------------------------------------------------------------------------------- A[AG][TC]GAAAG -------------------------------------------------------------------------------- Time 4.61 secs. ******************************************************************************** ******************************************************************************** MOTIF YCAGTCWT MEME-4 width = 8 sites = 12 llr = 101 E-value = 4.3e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif YCAGTCWT MEME-4 Description -------------------------------------------------------------------------------- Simplified A ::9:::6: pos.-specific C 6a1::a:: probability G :::82::: matrix T 4::38:4a bits 2.3 * * 2.0 * * 1.8 * * * 1.6 * * * Relative 1.4 *** * * Entropy 1.1 ****** * (12.2 bits) 0.9 ******** 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel CCAGTCAT consensus T T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCAGTCWT MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr4:89449067-89449087 6 1.33e-05 TCCAT CCAGTCAT TTCTGCA chr13:50941114-50941134 13 1.33e-05 AACCTCTTCT CCAGTCAT chr4:37893441-37893461 2 1.33e-05 A CCAGTCAT TTTGAAACCC chr3:56787414-56787434 9 2.66e-05 GTAGCAGA CCAGTCTT AGTC chr12:66150847-66150867 1 6.38e-05 . TCAGTCTT CTTGTTTCCG chr15:74834347-74834367 11 6.38e-05 CTGAGTCATC TCAGTCTT AC chr2:227849559-227849579 2 7.36e-05 A CCAGGCAT CAGGCACAGT chr22:26145920-26145940 3 9.16e-05 gc ccattcat ttacgtacta chr1:243751669-243751689 6 1.33e-04 AACTC TCAGGCAT TCAGTAG chr5:171416411-171416431 4 1.68e-04 taa cccgtcat taagtgcct chr2:100752953-100752973 12 2.17e-04 ATGACTGTCC TCATTCTT G chr6:111809034-111809054 11 2.17e-04 actttccctt tcattctt tg -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCAGTCWT MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr4:89449067-89449087 1.3e-05 5_[+4]_7 chr13:50941114-50941134 1.3e-05 12_[+4] chr4:37893441-37893461 1.3e-05 1_[+4]_11 chr3:56787414-56787434 2.7e-05 8_[+4]_4 chr12:66150847-66150867 6.4e-05 [+4]_12 chr15:74834347-74834367 6.4e-05 10_[+4]_2 chr2:227849559-227849579 7.4e-05 1_[+4]_11 chr22:26145920-26145940 9.2e-05 2_[+4]_10 chr1:243751669-243751689 0.00013 5_[+4]_7 chr5:171416411-171416431 0.00017 3_[+4]_9 chr2:100752953-100752973 0.00022 11_[+4]_1 chr6:111809034-111809054 0.00022 10_[+4]_2 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCAGTCWT MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF YCAGTCWT width=8 seqs=12 chr4:89449067-89449087 ( 6) CCAGTCAT 1 chr13:50941114-50941134 ( 13) CCAGTCAT 1 chr4:37893441-37893461 ( 2) CCAGTCAT 1 chr3:56787414-56787434 ( 9) CCAGTCTT 1 chr12:66150847-66150867 ( 1) TCAGTCTT 1 chr15:74834347-74834367 ( 11) TCAGTCTT 1 chr2:227849559-227849579 ( 2) CCAGGCAT 1 chr22:26145920-26145940 ( 3) CCATTCAT 1 chr1:243751669-243751689 ( 6) TCAGGCAT 1 chr5:171416411-171416431 ( 4) CCCGTCAT 1 chr2:100752953-100752973 ( 12) TCATTCTT 1 chr6:111809034-111809054 ( 11) TCATTCTT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCAGTCWT MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 9.17831 E= 4.3e+002 -1023 149 -1023 52 -1023 227 -1023 -1023 166 -131 -1023 -1023 -1023 -1023 181 -21 -1023 -1023 -36 152 -1023 227 -1023 -1023 101 -1023 -1023 52 -1023 -1023 -1023 178 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCAGTCWT MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 12 E= 4.3e+002 0.000000 0.583333 0.000000 0.416667 0.000000 1.000000 0.000000 0.000000 0.916667 0.083333 0.000000 0.000000 0.000000 0.000000 0.750000 0.250000 0.000000 0.000000 0.166667 0.833333 0.000000 1.000000 0.000000 0.000000 0.583333 0.000000 0.000000 0.416667 0.000000 0.000000 0.000000 1.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif YCAGTCWT MEME-4 regular expression -------------------------------------------------------------------------------- [CT]CA[GT]TC[AT]T -------------------------------------------------------------------------------- Time 5.52 secs. ******************************************************************************** ******************************************************************************** MOTIF ASTTTCAS MEME-5 width = 8 sites = 13 llr = 108 E-value = 6.9e+002 ******************************************************************************** -------------------------------------------------------------------------------- Motif ASTTTCAS MEME-5 Description -------------------------------------------------------------------------------- Simplified A 8:::::7: pos.-specific C :6:::a15 probability G 24:::::5 matrix T ::aaa:2: bits 2.3 * 2.0 * 1.8 **** 1.6 **** Relative 1.4 ***** * Entropy 1.1 ****** * (12.0 bits) 0.9 ****** * 0.7 ******** 0.5 ******** 0.2 ******** 0.0 -------- Multilevel ACTTTCAC consensus GG TG sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ASTTTCAS MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2:230865361-230865381 7 1.81e-05 ACTATT ACTTTCAC TCTTAG chr5:17343978-17343998 7 1.81e-05 TTGTTT ACTTTCAC ATTCAT chr12:105134692-10513471 6 1.81e-05 GTTCC ACTTTCAC TATGATT chr2:216910030-216910050 13 3.67e-05 ctactcaaac actttcag chr5:123860442-123860462 3 5.53e-05 TG AGTTTCAC TTCTGCTATG chr10:126303066-12630308 9 7.44e-05 ATAACTGA AGTTTCAG GTTT chr2:213595938-213595958 11 8.77e-05 GTCATTTCAA GCTTTCAC TC chr7:41771741-41771761 3 1.01e-04 CC GCTTTCAG TGTGTGCTGA chr12:108967285-10896730 11 1.20e-04 ctatgactgt ACTTTCTC TA chr2:47137042-47137062 2 1.66e-04 T GGTTTCAG AATGACTCAT chr11:64099445-64099465 2 2.04e-04 C AGTTTCTG AATGACTCCT chr3:113962013-113962033 5 2.04e-04 AATG AGTTTCTG TTTTGCTC chr6:111809034-111809054 1 2.17e-04 . actttccc tttcattctt -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ASTTTCAS MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2:230865361-230865381 1.8e-05 6_[+5]_6 chr5:17343978-17343998 1.8e-05 6_[+5]_6 chr12:105134692-10513471 1.8e-05 5_[+5]_7 chr2:216910030-216910050 3.7e-05 12_[+5] chr5:123860442-123860462 5.5e-05 2_[+5]_10 chr10:126303066-12630308 7.4e-05 8_[+5]_4 chr2:213595938-213595958 8.8e-05 10_[+5]_2 chr7:41771741-41771761 0.0001 2_[+5]_10 chr12:108967285-10896730 0.00012 10_[+5]_2 chr2:47137042-47137062 0.00017 1_[+5]_11 chr11:64099445-64099465 0.0002 1_[+5]_11 chr3:113962013-113962033 0.0002 4_[+5]_8 chr6:111809034-111809054 0.00022 [+5]_12 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ASTTTCAS MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF ASTTTCAS width=8 seqs=13 chr2:230865361-230865381 ( 7) ACTTTCAC 1 chr5:17343978-17343998 ( 7) ACTTTCAC 1 chr12:105134692-10513471 ( 6) ACTTTCAC 1 chr2:216910030-216910050 ( 13) ACTTTCAG 1 chr5:123860442-123860462 ( 3) AGTTTCAC 1 chr10:126303066-12630308 ( 9) AGTTTCAG 1 chr2:213595938-213595958 ( 11) GCTTTCAC 1 chr7:41771741-41771761 ( 3) GCTTTCAG 1 chr12:108967285-10896730 ( 11) ACTTTCTC 1 chr2:47137042-47137062 ( 2) GGTTTCAG 1 chr11:64099445-64099465 ( 2) AGTTTCTG 1 chr3:113962013-113962033 ( 5) AGTTTCTG 1 chr6:111809034-111809054 ( 1) ACTTTCCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ASTTTCAS MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 3250 bayes= 8.4923 E= 6.9e+002 141 -1035 11 -1035 -1035 157 85 -1035 -1035 -1035 -1035 178 -1035 -1035 -1035 178 -1035 -1035 -1035 178 -1035 227 -1035 -1035 126 -143 -1035 -33 -1035 138 111 -1035 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ASTTTCAS MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 13 E= 6.9e+002 0.769231 0.000000 0.230769 0.000000 0.000000 0.615385 0.384615 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 0.692308 0.076923 0.000000 0.230769 0.000000 0.538462 0.461538 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif ASTTTCAS MEME-5 regular expression -------------------------------------------------------------------------------- [AG][CG]TTTC[AT][CG] -------------------------------------------------------------------------------- Time 6.25 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr1:7278493-7278513 8.50e-01 20 chr8:134165344-134165364 1.80e-03 [+1(3.77e-05)]_12 chr2:216910030-216910050 8.85e-03 12_[+5(3.67e-05)] chr4:187055606-187055626 1.50e-02 20 chr11:115456286-11545630 7.83e-03 9_[+2(3.32e-05)]_3 chr8:26105972-26105992 8.51e-03 12_[+1(3.77e-05)] chr2:47137042-47137062 3.66e-05 11_[+1(3.77e-05)]_1 chr12:105134692-10513471 8.36e-03 5_[+5(1.81e-05)]_7 chr1:205309048-205309068 5.47e-04 5_[+1(3.77e-05)]_7 chr7:37758892-37758912 7.53e-02 20 chr1:205569456-205569476 1.85e-03 20 chr4:185339237-185339257 1.21e-02 3_[+1(3.77e-05)]_9 chr3:122252858-122252878 1.20e-02 20 chr14:68147020-68147040 6.69e-01 20 chr6:14666315-14666335 5.41e-01 20 chr15:101679285-10167930 4.59e-01 20 chr11:102239379-10223939 2.88e-01 20 chr5:172117439-172117459 7.40e-01 20 chr3:197588304-197588324 1.42e-01 20 chr9:109935364-109935384 4.80e-01 20 chr17:25566257-25566277 2.12e-02 20 chr10:6178435-6178455 3.50e-02 20 chr1:101001724-101001744 2.56e-02 20 chr2:227849559-227849579 1.75e-02 1_[+4(7.36e-05)]_11 chr4:113249228-113249248 7.26e-01 20 chr10:17274496-17274516 1.43e-01 20 chr12:96896512-96896532 2.06e-01 20 chr10:101934660-10193468 1.04e-02 12_[+2(3.32e-05)] chr14:93029913-93029933 5.85e-01 20 chr7:139912487-139912507 5.02e-01 20 chr18:13019461-13019481 5.14e-01 20 chr18:10838790-10838810 8.86e-01 20 chr11:123173602-12317362 5.28e-01 20 chr4:62648922-62648942 3.19e-03 8_[+1(3.77e-05)]_4 chr11:4721118-4721138 3.43e-03 3_[+1(3.77e-05)]_9 chr9:138998444-138998464 2.57e-02 20 chr2:98583564-98583584 2.26e-02 20 chr22:26145920-26145940 8.18e-02 2_[+4(9.16e-05)]_10 chr10:35630610-35630630 2.81e-01 20 chr9:97658178-97658198 9.01e-02 20 chr5:116032261-116032281 4.18e-01 20 chr3:127481563-127481583 2.10e-01 20 chr19:19521771-19521791 2.11e-03 12_[+2(1.91e-05)] chr9:126080668-126080688 6.92e-02 20 chr5:114796279-114796299 5.91e-01 20 chr3:155213419-155213439 2.04e-01 20 chr5:167676232-167676252 1.99e-02 20 chr11:87913314-87913334 6.45e-04 10_[+1(3.77e-05)]_2 chr10:98348965-98348985 4.03e-02 4_[+3(4.61e-05)]_8 chr3:124295548-124295568 7.01e-01 20 chr3:144014187-144014207 1.35e-02 20 chr17:68133684-68133704 5.29e-02 20 chr2:12641783-12641803 7.62e-02 20 chr15:90752997-90753017 9.64e-05 1_[+2(6.65e-05)]_11 chr3:138232511-138232531 1.64e-02 2_[+1(3.77e-05)]_10 chr5:150831504-150831524 7.89e-03 4_[+1(3.77e-05)]_8 chr7:7298141-7298161 3.66e-01 20 chr2:20565320-20565340 4.24e-01 20 chr5:99501210-99501230 5.02e-01 20 chr7:75224329-75224349 6.56e-02 20 chr9:95853888-95853908 6.18e-01 20 chr17:48360762-48360782 3.45e-01 20 chr6:148941918-148941938 4.12e-02 [+2(3.32e-05)]_12 chr15:79965942-79965962 7.95e-01 20 chr8:8807490-8807510 4.69e-01 20 chr6:68836421-68836441 3.97e-02 20 chr12:68513622-68513642 3.51e-01 20 chr2:111926243-111926263 1.47e-02 6_[+1(6.54e-05)]_6 chr4:103456716-103456736 5.58e-04 2_[+1(3.77e-05)]_10 chr17:78232786-78232806 1.04e-01 20 chr12:68104493-68104513 2.94e-02 20 chr12:65054551-65054571 1.36e-02 3_[+1(6.54e-05)]_9 chr2:225822456-225822476 1.73e-01 20 chr10:124052876-12405289 3.89e-02 20 chr4:105887966-105887986 2.62e-01 20 chr9:100062278-100062298 7.53e-01 20 chr12:108967285-10896730 1.78e-04 2_[+2(1.91e-05)]_10 chr19:33726617-33726637 2.13e-01 20 chr17:64028644-64028664 6.57e-01 20 chr2:20716894-20716914 5.55e-01 20 chr9:1536685-1536705 5.41e-01 20 chr2:204736418-204736438 7.02e-02 20 chr10:126303066-12630308 3.46e-04 8_[+5(7.44e-05)]_4 chr3:113962013-113962033 5.50e-03 20 chr1:113574073-113574093 5.86e-04 11_[+3(4.61e-05)]_1 chr19:36202394-36202414 1.82e-02 [+1(3.77e-05)]_12 chr2:10054941-10054961 2.34e-02 20 chr15:57079328-57079348 6.80e-01 20 chr18:21826310-21826330 7.53e-01 20 chr1:167632335-167632355 8.76e-01 20 chr1:28624519-28624539 7.77e-03 8_[+1(6.54e-05)]_4 chr18:77467860-77467880 8.94e-02 20 chrX:71569231-71569251 8.73e-01 20 chr20:3400955-3400975 1.93e-02 4_[+3(2.65e-05)]_8 chr3:34112532-34112552 5.24e-01 20 chr8:64314658-64314678 7.06e-01 20 chr6:73450048-73450068 6.83e-04 5_[+1(3.77e-05)]_7 chr5:78281581-78281601 7.09e-01 20 chr9:102574134-102574154 1.04e-03 8_[+4(6.38e-05)]_4 chr2:175257622-175257642 1.99e-03 10_[+1(3.77e-05)]_2 chr17:8842947-8842967 1.35e-02 11_[+2(1.91e-05)]_1 chr15:74834347-74834367 1.34e-04 1_[+1(3.77e-05)]_1_[+4(6.38e-05)]_2 chr18:42289907-42289927 1.07e-04 8_[+3(2.65e-05)]_4 chr16:29655812-29655832 1.89e-02 1_[+3(4.61e-05)]_11 chr4:37893441-37893461 5.95e-03 1_[+4(1.33e-05)]_11 chr4:24858298-24858318 9.41e-03 20 chr5:55273988-55274008 1.20e-02 20 chr16:80614581-80614601 1.78e-03 9_[+1(3.77e-05)]_3 chr5:123919621-123919641 3.77e-02 20 chr1:32332148-32332168 3.14e-01 20 chr9:5510502-5510522 6.80e-01 20 chr18:13375424-13375444 1.96e-01 20 chr11:10548942-10548962 4.71e-01 20 chr5:130731844-130731864 2.65e-02 20 chr20:30866320-30866340 2.67e-01 20 chr3:45926524-45926544 2.82e-01 20 chr3:112770269-112770289 4.45e-04 4_[+1(3.77e-05)]_8 chr3:125819669-125819689 7.34e-01 20 chr2:65214578-65214598 1.18e-02 20 chr20:19928705-19928725 8.20e-04 7_[+1(3.77e-05)]_5 chr1:243751669-243751689 1.48e-03 20 chr17:79218863-79218883 8.43e-02 20 chr11:70170670-70170690 2.68e-02 7_[+3(6.50e-05)]_5 chr6:90790737-90790757 1.01e-03 2_[+2(1.91e-05)]_10 chr3:29725348-29725368 1.96e-02 20 chr1:159091919-159091939 3.62e-02 20 chr11:72064421-72064441 6.62e-04 7_[+2(1.91e-05)]_5 chr11:66659811-66659831 2.24e-01 20 chr15:59661997-59662017 1.81e-03 20 chr9:134882593-134882613 4.58e-02 20 chr5:52063789-52063809 5.11e-01 20 chr8:42046618-42046638 4.37e-03 20 chr6:158221809-158221829 1.26e-03 1_[+4(6.38e-05)]_11 chr2:208021780-208021800 5.01e-02 20 chr10:120458164-12045818 1.39e-03 20 chr11:128627948-12862796 4.38e-02 20 chr5:176791746-176791766 2.57e-03 20 chr5:156543572-156543592 9.28e-01 20 chr11:48028396-48028416 8.99e-01 20 chr12:105324607-10532462 1.60e-03 2_[+4(4.52e-05)]_10 chr4:146950482-146950502 8.88e-01 20 chr5:144436564-144436584 9.83e-02 20 chr13:32505237-32505257 2.58e-02 20 chr15:36222114-36222134 1.29e-02 7_[+1(6.54e-05)]_5 chr7:105406939-105406959 5.60e-02 20 chr2:111858579-111858599 1.05e-03 8_[+1(3.77e-05)]_4 chr8:94966974-94966994 3.09e-02 20 chr10:10911762-10911782 1.94e-03 12_[+1(3.77e-05)] chr6:130544784-130544804 3.29e-03 20 chr2:20725229-20725249 4.00e-01 20 chr8:37595310-37595330 2.74e-01 20 chr6:73359500-73359520 9.10e-01 20 chr8:54798657-54798677 6.50e-03 20 chr2:146506723-146506743 2.09e-01 20 chr12:124611708-12461172 8.58e-01 20 chr2:191587399-191587419 9.55e-01 20 chr10:81026651-81026671 1.06e-02 20 chr10:329949-329969 9.11e-01 20 chr2:149361339-149361359 7.30e-04 2_[+1(3.77e-05)]_10 chr12:104856868-10485688 1.49e-02 20 chr4:25125052-25125072 1.19e-04 11_[+3(6.50e-05)]_1 chr5:123860442-123860462 2.55e-02 2_[+5(5.53e-05)]_10 chr3:159579609-159579629 1.44e-02 11_[+1(6.54e-05)]_1 chr6:155095135-155095155 1.67e-02 [+2(9.25e-05)]_12 chr3:11862113-11862133 3.76e-03 2_[+1(3.77e-05)]_10 chr9:117457302-117457322 7.88e-01 20 chr16:23304523-23304543 7.45e-02 20 chr13:50941114-50941134 2.27e-02 12_[+4(1.33e-05)] chr6:15876905-15876925 8.51e-01 20 chr11:64099445-64099465 6.34e-04 20 chr21:36423049-36423069 5.56e-03 20 chr5:171416411-171416431 4.25e-02 20 chr21:39621348-39621368 1.95e-02 20 chr9:33988643-33988663 5.62e-02 20 chr5:17343978-17343998 6.63e-04 6_[+5(1.81e-05)]_6 chr4:56484181-56484201 1.57e-02 20 chr9:136001487-136001507 2.49e-01 20 chr10:32438225-32438245 1.05e-01 20 chr7:7805252-7805272 8.37e-02 20 chr4:89449067-89449087 5.14e-03 5_[+4(1.33e-05)]_7 chr16:48222580-48222600 1.05e-02 20 chr8:126315437-126315457 5.82e-01 20 chr19:39842329-39842349 1.19e-01 20 chr12:92172802-92172822 1.34e-02 20 chr4:145277688-145277708 3.63e-01 20 chr11:102482223-10248224 5.29e-01 20 chr1:198143686-198143706 7.20e-01 20 chr18:650547-650567 2.85e-02 9_[+2(4.68e-05)]_3 chr1:249088002-249088022 4.47e-01 20 chr13:50798832-50798852 6.38e-01 20 chr14:70142959-70142979 3.39e-01 20 chr15:48106424-48106444 5.51e-03 [+3(6.50e-05)]_12 chr8:131457220-131457240 5.76e-01 20 chr5:33934128-33934148 5.91e-01 20 chr1:63087844-63087864 5.40e-01 20 chrX:62975957-62975977 2.09e-01 20 chr11:108094757-10809477 3.00e-03 20 chr1:200849608-200849628 3.81e-01 20 chr15:57833094-57833114 2.63e-02 20 chr10:74397361-74397381 7.29e-01 20 chr3:56787414-56787434 6.42e-03 8_[+4(2.66e-05)]_4 chr3:114598310-114598330 7.31e-01 20 chr4:36653068-36653088 4.45e-01 20 chr3:186228293-186228313 4.45e-01 20 chr11:133847075-13384709 2.05e-02 20 chr1:206942960-206942980 8.11e-01 20 chr6:111809034-111809054 5.87e-03 20 chr22:45650985-45651005 5.99e-03 1_[+2(1.91e-05)]_11 chr10:27026885-27026905 2.53e-01 20 chr22:28291759-28291779 5.61e-01 20 chr18:74775384-74775404 5.98e-01 20 chr21:43422723-43422743 9.16e-03 20 chr15:60211725-60211745 8.85e-01 20 chr2:100752953-100752973 9.28e-05 1_[+2(1.91e-05)]_11 chr2:230865361-230865381 3.66e-04 6_[+5(1.81e-05)]_6 chr1:213151256-213151276 1.08e-01 20 chr5:54198792-54198812 9.28e-01 20 chr5:169083269-169083289 3.40e-01 20 chr7:41771741-41771761 8.05e-03 20 chr9:113388923-113388943 5.62e-02 20 chr18:53779801-53779821 5.74e-01 20 chr2:12434196-12434216 1.13e-03 [+1(3.77e-05)]_12 chr1:198638368-198638388 1.11e-02 20 chr8:38401229-38401249 8.56e-01 20 chr8:124560667-124560687 4.36e-04 7_[+1(3.77e-05)]_5 chr5:60122678-60122698 3.31e-01 20 chr12:122430305-12243032 2.17e-01 20 chr12:18318667-18318687 9.13e-01 20 chr6:158897055-158897075 1.80e-01 20 chr8:84860641-84860661 5.73e-01 20 chr12:123478187-12347820 2.17e-01 20 chr17:63653085-63653105 7.07e-01 20 chrX:96294876-96294896 9.17e-01 20 chr2:213595938-213595958 5.10e-03 10_[+5(8.77e-05)]_2 chr11:95846123-95846143 5.65e-01 20 chr11:83324661-83324681 1.50e-02 20 chr12:919999-920019 5.68e-01 20 chr19:10987536-10987556 3.74e-04 12_[+2(1.91e-05)] chr9:123980338-123980358 1.19e-02 20 chr2:216782997-216783017 1.41e-01 20 chr12:94699488-94699508 7.82e-01 20 chr12:66150847-66150867 1.25e-02 [+4(6.38e-05)]_12 chr1:234033246-234033266 3.59e-01 20 chr1:219638776-219638796 3.93e-02 20 chr3:150502327-150502347 4.98e-01 20 chr2:48475897-48475917 6.70e-01 20 chr11:43575526-43575546 1.48e-01 20 chr10:79805203-79805223 8.00e-03 20 chr20:1612982-1613002 1.78e-01 20 chr11:125860255-12586027 9.91e-01 20 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c22n04.farnam.hpc.yale.internal ********************************************************************************