******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 5.3.3 (Release date: Sun Feb 7 15:39:52 2021 -0800) For further information on how to interpret these results please access https://meme-suite.org/meme. To get a copy of the MEME Suite software please access https://meme-suite.org. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** PRIMARY SEQUENCES= ../result/final_prediction/fly/fasta/RankLinear8.0_60/CG8301.fasta CONTROL SEQUENCES= --none-- ALPHABET= ACGT Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ chr2L:20328728-20328848 1.0000 120 chr3L:14296547-14296667 1.0000 120 chr3R:16485976-16486096 1.0000 120 chr2R:22316003-22316123 1.0000 120 chr3R:26894038-26894158 1.0000 120 chr3L:5626612-5626732 1.0000 120 chr2L:4622076-4622196 1.0000 120 chr3R:18491284-18491404 1.0000 120 chr3R:19788912-19789032 1.0000 120 chr2L:734266-734386 1.0000 120 chr2L:2185501-2185621 1.0000 120 chr2L:14259925-14260045 1.0000 120 chr3L:14440702-14440822 1.0000 120 chrX:8163585-8163705 1.0000 120 chr3L:2162757-2162877 1.0000 120 chr3L:12025076-12025196 1.0000 120 chr2R:7112213-7112333 1.0000 120 chr3L:4398044-4398164 1.0000 120 chr2L:7627634-7627754 1.0000 120 chr2R:22727185-22727305 1.0000 120 chr3R:26481383-26481503 1.0000 120 chr2L:18746826-18746946 1.0000 120 chrX:7637252-7637372 1.0000 120 chrX:15156413-15156533 1.0000 120 chr3L:6263577-6263697 1.0000 120 chr3R:29211841-29211961 1.0000 120 chrX:9654097-9654217 1.0000 120 chr2L:7513824-7513944 1.0000 120 chr3L:15708690-15708810 1.0000 120 chrX:15165056-15165176 1.0000 120 chr3R:16523563-16523683 1.0000 120 chr2L:3645502-3645622 1.0000 120 chr3L:9745524-9745644 1.0000 120 chr3L:21224375-21224495 1.0000 120 chr3R:4957940-4958060 1.0000 120 chr2R:18656789-18656909 1.0000 120 chr3L:12073216-12073336 1.0000 120 chr2R:7114692-7114812 1.0000 120 chr2L:4619362-4619482 1.0000 120 chrX:15639178-15639298 1.0000 120 chr2R:14083116-14083236 1.0000 120 chr3R:10531899-10532019 1.0000 120 chr3R:18486308-18486428 1.0000 120 chrX:715513-715633 1.0000 120 chr3L:8319235-8319355 1.0000 120 chr3R:23392380-23392500 1.0000 120 chr3R:22400383-22400503 1.0000 120 chr2L:18348782-18348902 1.0000 120 chr3L:21223441-21223561 1.0000 120 chr3R:21979529-21979649 1.0000 120 chr3L:18096871-18096991 1.0000 120 chr2L:4648945-4649065 1.0000 120 chrX:13951543-13951663 1.0000 120 chr2L:2184823-2184943 1.0000 120 chr2R:15233496-15233616 1.0000 120 chr3R:28842070-28842190 1.0000 120 chr3L:5609633-5609753 1.0000 120 chr3L:2582481-2582601 1.0000 120 chr3R:31314607-31314727 1.0000 120 chr3L:3555201-3555321 1.0000 120 chr2L:1538239-1538359 1.0000 120 chr3R:22150064-22150184 1.0000 120 chr3R:31944355-31944475 1.0000 120 chr2R:21801059-21801179 1.0000 120 chr2L:3482152-3482272 1.0000 120 chr3R:9228063-9228183 1.0000 120 chr2R:24925993-24926113 1.0000 120 chr3L:18231531-18231651 1.0000 120 chr2L:3576634-3576754 1.0000 120 chrX:3005911-3006031 1.0000 120 chr3R:12315588-12315708 1.0000 120 chr2L:653934-654054 1.0000 120 chrX:11736575-11736695 1.0000 120 chr2L:20370311-20370431 1.0000 120 chr2R:12739857-12739977 1.0000 120 chr2R:16706833-16706953 1.0000 120 chr2R:15600061-15600181 1.0000 120 chr3L:14616792-14616912 1.0000 120 chr3L:17981248-17981368 1.0000 120 chr2R:21783621-21783741 1.0000 120 chr3R:18488019-18488139 1.0000 120 chr2L:3858233-3858353 1.0000 120 chr3L:1484902-1485022 1.0000 120 chr3R:30344701-30344821 1.0000 120 chr3R:15113699-15113819 1.0000 120 chr2R:7161983-7162103 1.0000 120 chr2L:3002092-3002212 1.0000 120 chrX:5924507-5924627 1.0000 120 chr3R:27181227-27181347 1.0000 120 chr3R:22395534-22395654 1.0000 120 chr2R:13291889-13292009 1.0000 120 chr3R:6214374-6214494 1.0000 120 chr3R:26478168-26478288 1.0000 120 chr3R:12381446-12381566 1.0000 120 chr2L:7956471-7956591 1.0000 120 chr3R:30872821-30872941 1.0000 120 chr2R:10847453-10847573 1.0000 120 chrX:15163522-15163642 1.0000 120 chr2R:11315542-11315662 1.0000 120 chr2L:4065330-4065450 1.0000 120 chr3R:30890195-30890315 1.0000 120 chr3R:22576368-22576488 1.0000 120 chr2R:17845697-17845817 1.0000 120 chr2R:21377272-21377392 1.0000 120 chr2R:21300886-21301006 1.0000 120 chr2R:12720709-12720829 1.0000 120 chrX:724608-724728 1.0000 120 chr2L:4797716-4797836 1.0000 120 chr3L:4745271-4745391 1.0000 120 chr2L:15474535-15474655 1.0000 120 chr3R:18485366-18485486 1.0000 120 chrX:4999154-4999274 1.0000 120 chr2L:18752902-18753022 1.0000 120 chr2L:4635505-4635625 1.0000 120 chr3R:29072972-29073092 1.0000 120 chr2L:20335074-20335194 1.0000 120 chr3L:4271566-4271686 1.0000 120 chr3L:14422261-14422381 1.0000 120 chr3L:10376807-10376927 1.0000 120 chr3R:15567081-15567201 1.0000 120 chr3R:30833239-30833359 1.0000 120 chrX:4963101-4963221 1.0000 120 chr2L:604253-604373 1.0000 120 chr2L:18752165-18752285 1.0000 120 chr2R:20568461-20568581 1.0000 120 chr3L:741857-741977 1.0000 120 chr3L:22106837-22106957 1.0000 120 chr2R:8646576-8646696 1.0000 120 chr2L:21004954-21005074 1.0000 120 chrX:9653397-9653517 1.0000 120 chr3L:8782129-8782249 1.0000 120 chr2L:18744014-18744134 1.0000 120 chr3R:13843739-13843859 1.0000 120 chr3L:6308749-6308869 1.0000 120 chr2R:23198690-23198810 1.0000 120 chr3R:14456559-14456679 1.0000 120 chr3R:24204147-24204267 1.0000 120 chr2L:20721589-20721709 1.0000 120 chrX:1979130-1979250 1.0000 120 chrX:4959045-4959165 1.0000 120 chr3L:17504698-17504818 1.0000 120 chr3L:21918724-21918844 1.0000 120 chr3R:14486615-14486735 1.0000 120 chrX:5002907-5003027 1.0000 120 chr3R:22158491-22158611 1.0000 120 chr2L:21246810-21246930 1.0000 120 chr3L:18076764-18076884 1.0000 120 chr3R:30567378-30567498 1.0000 120 chrX:18558698-18558818 1.0000 120 chrX:8839516-8839636 1.0000 120 chr3R:22594371-22594491 1.0000 120 chr2R:16212944-16213064 1.0000 120 chrX:8747763-8747883 1.0000 120 chr2L:20340783-20340903 1.0000 120 chr3R:8875884-8876004 1.0000 120 chr3L:19329631-19329751 1.0000 120 chr2R:18899103-18899223 1.0000 120 chr2R:20055449-20055569 1.0000 120 chr2L:21108312-21108432 1.0000 120 chr3R:31767717-31767837 1.0000 120 chr3L:20983389-20983509 1.0000 120 chr3L:20610534-20610654 1.0000 120 chr3L:15187901-15188021 1.0000 120 chr3R:24024278-24024398 1.0000 120 chr3L:7632941-7633061 1.0000 120 chr3R:18493932-18494052 1.0000 120 chr2L:4886293-4886413 1.0000 120 chr3R:13797459-13797579 1.0000 120 chr3L:6396040-6396160 1.0000 120 chr2R:17811094-17811214 1.0000 120 chrX:5013178-5013298 1.0000 120 chr2L:18725003-18725123 1.0000 120 chr2L:20328101-20328221 1.0000 120 chrX:4170633-4170753 1.0000 120 chr3R:5324241-5324361 1.0000 120 chr3L:11448477-11448597 1.0000 120 chr2L:19307812-19307932 1.0000 120 chr2L:9669511-9669631 1.0000 120 chr3R:16042921-16043041 1.0000 120 chr2R:23306110-23306230 1.0000 120 chr2R:7173197-7173317 1.0000 120 chr3R:22727955-22728075 1.0000 120 chr3R:26019362-26019482 1.0000 120 chr3R:29847251-29847371 1.0000 120 chr2R:8645847-8645967 1.0000 120 chr3L:4707961-4708081 1.0000 120 chr3L:8765645-8765765 1.0000 120 chr2R:13933396-13933516 1.0000 120 chr3L:5945713-5945833 1.0000 120 chrX:18800341-18800461 1.0000 120 chr2L:3731157-3731277 1.0000 120 chr3L:9566997-9567117 1.0000 120 chrX:3454850-3454970 1.0000 120 chr3L:13215045-13215165 1.0000 120 chr2R:14081672-14081792 1.0000 120 chr2L:18331774-18331894 1.0000 120 chr3L:590019-590139 1.0000 120 chr3L:10386318-10386438 1.0000 120 chr3L:756520-756640 1.0000 120 chr2R:19904084-19904204 1.0000 120 chr2L:19317947-19318067 1.0000 120 chr2R:18663210-18663330 1.0000 120 chr3R:23737807-23737927 1.0000 120 chr3R:12297346-12297466 1.0000 120 chr3R:26496489-26496609 1.0000 120 chrX:3739296-3739416 1.0000 120 chr2L:7938613-7938733 1.0000 120 chr3L:8860048-8860168 1.0000 120 chr3L:4346489-4346609 1.0000 120 chr3L:21237140-21237260 1.0000 120 chrX:2796756-2796876 1.0000 120 chr3L:10396685-10396805 1.0000 120 chrX:9738628-9738748 1.0000 120 chr2R:23761503-23761623 1.0000 120 chr3R:30312642-30312762 1.0000 120 chr3L:2533176-2533296 1.0000 120 chr3R:31768335-31768455 1.0000 120 chr3R:31901714-31901834 1.0000 120 chr3L:3657014-3657134 1.0000 120 chr2R:8358045-8358165 1.0000 120 chr2L:3624934-3625054 1.0000 120 chr3R:23324059-23324179 1.0000 120 chr2L:7043642-7043762 1.0000 120 chr3L:787757-787877 1.0000 120 chr3R:19075223-19075343 1.0000 120 chr3R:23416687-23416807 1.0000 120 chr3R:4687343-4687463 1.0000 120 chr2L:15466087-15466207 1.0000 120 chr3L:6084618-6084738 1.0000 120 chr2L:14624016-14624136 1.0000 120 chr3L:16643131-16643251 1.0000 120 chr2L:18005640-18005760 1.0000 120 chr3R:9581109-9581229 1.0000 120 chr2R:17635145-17635265 1.0000 120 chr2L:8585204-8585324 1.0000 120 chr3R:19070716-19070836 1.0000 120 chr2L:19574575-19574695 1.0000 120 chr3L:18628256-18628376 1.0000 120 chrX:13238651-13238771 1.0000 120 chrX:1988829-1988949 1.0000 120 chr3L:7264258-7264378 1.0000 120 chr3R:29982170-29982290 1.0000 120 chr2L:843985-844105 1.0000 120 chr2L:5567216-5567336 1.0000 120 chr3L:14534747-14534867 1.0000 120 chr3R:20280691-20280811 1.0000 120 chr3R:19255404-19255524 1.0000 120 chr3L:11536874-11536994 1.0000 120 chr2R:6521281-6521401 1.0000 120 chr2R:17076994-17077114 1.0000 120 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme -oc ../result/final_prediction/fly/inference_raw/MEME/RankLinear8.0_60_CG8301/ -dna -nmotifs 5 -w 8 -maxsize 250000 -nostatus ../result/final_prediction/fly/fasta/RankLinear8.0_60/CG8301.fasta model: mod= zoops nmotifs= 5 evt= inf objective function: em= E-value of product of p-values starts= E-value of product of p-values strands: + width: minw= 8 maxw= 8 nsites: minsites= 2 maxsites= 250 wnsites= 0.8 theta: spmap= uni spfuzz= 0.5 em: prior= dirichlet b= 0.01 maxiter= 50 distance= 1e-05 trim: wg= 11 ws= 1 endgaps= yes data: n= 30000 N= 250 sample: seed= 0 hsfrac= 0 searchsize= 30000 norand= no csites= 1000 Letter frequencies in dataset: A 0.35 C 0.149 G 0.146 T 0.355 Background letter frequencies (from file dataset with add-one prior applied): A 0.35 C 0.149 G 0.146 T 0.355 Background model order: 0 ******************************************************************************** ******************************************************************************** MOTIF GGKGGCYC MEME-1 width = 8 sites = 4 llr = 52 E-value = 1.6e+003 ******************************************************************************** -------------------------------------------------------------------------------- Motif GGKGGCYC MEME-1 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C :::::a5a probability G aa5aa::: matrix T ::5:::5: bits 2.8 ** *** * 2.5 ** *** * 2.2 ** *** * 1.9 ** *** * Relative 1.7 ** *** * Entropy 1.4 ** *** * (18.9 bits) 1.1 ******** 0.8 ******** 0.6 ******** 0.3 ******** 0.0 -------- Multilevel GGGGGCCC consensus T T sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGKGGCYC MEME-1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr3L:6396040-6396160 12 2.19e-07 ACTTCTTTAA GGGGGCCC AAAAACGAGA chr3R:30312642-30312762 30 1.28e-06 AATGATTCAA GGTGGCCC CTTTTTGAAG chr2L:2184823-2184943 92 1.28e-06 taacttttaA GGGGGCTC CCTATTATTT chr2L:20340783-20340903 37 2.55e-06 GACGAAAGAA GGTGGCTC TTTTTAGGAG -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGKGGCYC MEME-1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr3L:6396040-6396160 2.2e-07 11_[+1]_101 chr3R:30312642-30312762 1.3e-06 29_[+1]_83 chr2L:2184823-2184943 1.3e-06 91_[+1]_21 chr2L:20340783-20340903 2.5e-06 36_[+1]_76 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGKGGCYC MEME-1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GGKGGCYC width=8 seqs=4 chr3L:6396040-6396160 ( 12) GGGGGCCC 1 chr3R:30312642-30312762 ( 30) GGTGGCCC 1 chr2L:2184823-2184943 ( 92) GGGGGCTC 1 chr2L:20340783-20340903 ( 37) GGTGGCTC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGKGGCYC MEME-1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 28250 bayes= 13.5228 E= 1.6e+003 -865 -865 277 -865 -865 -865 277 -865 -865 -865 177 49 -865 -865 277 -865 -865 -865 277 -865 -865 274 -865 -865 -865 174 -865 49 -865 274 -865 -865 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGKGGCYC MEME-1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 4 E= 1.6e+003 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.500000 0.500000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.500000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GGKGGCYC MEME-1 regular expression -------------------------------------------------------------------------------- GG[GT]GGC[CT]C -------------------------------------------------------------------------------- Time 7.40 secs. ******************************************************************************** ******************************************************************************** MOTIF GCCACATG MEME-2 width = 8 sites = 9 llr = 98 E-value = 1.3e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif GCCACATG MEME-2 Description -------------------------------------------------------------------------------- Simplified A :::a:9:: pos.-specific C :aa:9::: probability G 9:::1:19 matrix T 1::::191 bits 2.8 ** 2.5 ** 2.2 *** * * 1.9 *** * * Relative 1.7 *** * * Entropy 1.4 ***** * (15.7 bits) 1.1 ******** 0.8 ******** 0.6 ******** 0.3 ******** 0.0 -------- Multilevel GCCACATG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCACATG MEME-2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:1988829-1988949 103 3.07e-06 CAAGCCACAT GCCACATG CCACCTGCTC chr3L:11448477-11448597 84 3.07e-06 TTCTAGGGTA GCCACATG TGCATTTAGT chr3R:21979529-21979649 56 3.07e-06 TATTTAGTTT GCCACATG ACGTATTTTC chr3R:18491284-18491404 24 3.07e-06 ATATTATTAA GCCACATG GCGTGTGGAA chr2L:20328101-20328221 94 4.33e-06 ATAGACCCAG GCCACAGG CTATACTTAT chr3L:18076764-18076884 5 1.04e-05 TTTT GCCACTTG CAACTTTCTC chr2L:7956471-7956591 42 1.04e-05 TGTTTTTGTA GCCAGATG TTGTAAGCCA chr3L:5945713-5945833 40 2.54e-05 TATAAATAAA TCCACATG TTAAACAACT chr3R:26481383-26481503 95 2.54e-05 TTTTTAAGGT GCCACATT TCAATTATCT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCACATG MEME-2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:1988829-1988949 3.1e-06 102_[+2]_10 chr3L:11448477-11448597 3.1e-06 83_[+2]_29 chr3R:21979529-21979649 3.1e-06 55_[+2]_57 chr3R:18491284-18491404 3.1e-06 23_[+2]_89 chr2L:20328101-20328221 4.3e-06 93_[+2]_19 chr3L:18076764-18076884 1e-05 4_[+2]_108 chr2L:7956471-7956591 1e-05 41_[+2]_71 chr3L:5945713-5945833 2.5e-05 39_[+2]_73 chr3R:26481383-26481503 2.5e-05 94_[+2]_18 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCACATG MEME-2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF GCCACATG width=8 seqs=9 chrX:1988829-1988949 ( 103) GCCACATG 1 chr3L:11448477-11448597 ( 84) GCCACATG 1 chr3R:21979529-21979649 ( 56) GCCACATG 1 chr3R:18491284-18491404 ( 24) GCCACATG 1 chr2L:20328101-20328221 ( 94) GCCACAGG 1 chr3L:18076764-18076884 ( 5) GCCACTTG 1 chr2L:7956471-7956591 ( 42) GCCAGATG 1 chr3L:5945713-5945833 ( 40) TCCACATG 1 chr3R:26481383-26481503 ( 95) GCCACATT 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCACATG MEME-2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 28250 bayes= 11.7499 E= 1.3e+004 -982 -982 260 -167 -982 275 -982 -982 -982 275 -982 -982 151 -982 -982 -982 -982 258 -39 -982 134 -982 -982 -167 -982 -982 -39 132 -982 -982 260 -167 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCACATG MEME-2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 9 E= 1.3e+004 0.000000 0.000000 0.888889 0.111111 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.888889 0.111111 0.000000 0.888889 0.000000 0.000000 0.111111 0.000000 0.000000 0.111111 0.888889 0.000000 0.000000 0.888889 0.111111 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif GCCACATG MEME-2 regular expression -------------------------------------------------------------------------------- GCCACATG -------------------------------------------------------------------------------- Time 13.65 secs. ******************************************************************************** ******************************************************************************** MOTIF TCAGTGCA MEME-3 width = 8 sites = 7 llr = 80 E-value = 3.4e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif TCAGTGCA MEME-3 Description -------------------------------------------------------------------------------- Simplified A ::a::::7 pos.-specific C :a::::a3 probability G :::a:a:: matrix T a:::a::: bits 2.8 * * ** 2.5 * * ** 2.2 * * ** 1.9 * * ** Relative 1.7 * * ** Entropy 1.4 ******* (16.6 bits) 1.1 ******** 0.8 ******** 0.6 ******** 0.3 ******** 0.0 -------- Multilevel TCAGTGCA consensus C sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCAGTGCA MEME-3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2R:20568461-20568581 101 7.31e-06 TGTACTTCGC TCAGTGCA GCCTTGGGGC chr2L:7956471-7956591 106 7.31e-06 TTCATTTCGC TCAGTGCA TTAGTTC chr3R:18488019-18488139 78 7.31e-06 TTCATTATTT TCAGTGCA GATAGATTCG chr2L:18746826-18746946 11 7.31e-06 AACTGCAGCA TCAGTGCA TATATCAAGC chr3L:14440702-14440822 89 7.31e-06 ATTCTTAAAT TCAGTGCA CAGTGACTAA chr2R:7173197-7173317 63 1.04e-05 TCAAATTGTT TCAGTGCC ATAACTCTTA chr2R:21783621-21783741 102 1.04e-05 TTCATTTTTC TCAGTGCC CCAAACAAAT -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCAGTGCA MEME-3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2R:20568461-20568581 7.3e-06 100_[+3]_12 chr2L:7956471-7956591 7.3e-06 105_[+3]_7 chr3R:18488019-18488139 7.3e-06 77_[+3]_35 chr2L:18746826-18746946 7.3e-06 10_[+3]_102 chr3L:14440702-14440822 7.3e-06 88_[+3]_24 chr2R:7173197-7173317 1e-05 62_[+3]_50 chr2R:21783621-21783741 1e-05 101_[+3]_11 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCAGTGCA MEME-3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF TCAGTGCA width=8 seqs=7 chr2R:20568461-20568581 ( 101) TCAGTGCA 1 chr2L:7956471-7956591 ( 106) TCAGTGCA 1 chr3R:18488019-18488139 ( 78) TCAGTGCA 1 chr2L:18746826-18746946 ( 11) TCAGTGCA 1 chr3L:14440702-14440822 ( 89) TCAGTGCA 1 chr2R:7173197-7173317 ( 63) TCAGTGCC 1 chr2R:21783621-21783741 ( 102) TCAGTGCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCAGTGCA MEME-3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 28250 bayes= 10.9574 E= 3.4e+004 -945 -945 -945 149 -945 275 -945 -945 151 -945 -945 -945 -945 -945 277 -945 -945 -945 -945 149 -945 -945 277 -945 -945 275 -945 -945 103 94 -945 -945 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCAGTGCA MEME-3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 7 E= 3.4e+004 0.000000 0.000000 0.000000 1.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.714286 0.285714 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif TCAGTGCA MEME-3 regular expression -------------------------------------------------------------------------------- TCAGTGC[AC] -------------------------------------------------------------------------------- Time 19.89 secs. ******************************************************************************** ******************************************************************************** MOTIF CCCCCTSC MEME-4 width = 8 sites = 2 llr = 27 E-value = 3.4e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCCCCTSC MEME-4 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C aaaaa:5a probability G ::::::5: matrix T :::::a:: bits 2.8 ***** * 2.5 ***** * 2.2 ***** * 1.9 ***** * Relative 1.7 ***** ** Entropy 1.4 ******** (19.7 bits) 1.1 ******** 0.8 ******** 0.6 ******** 0.3 ******** 0.0 -------- Multilevel CCCCCTCC consensus G sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCCTSC MEME-4 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chrX:3454850-3454970 21 5.67e-07 AATAGCAATT CCCCCTGC AGCAACTTTT chr2R:23306110-23306230 82 1.15e-06 ATCATCAAAA CCCCCTCC ATTTCTGGGC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCCTSC MEME-4 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chrX:3454850-3454970 5.7e-07 20_[+4]_92 chr2R:23306110-23306230 1.1e-06 81_[+4]_31 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCCTSC MEME-4 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCCCCTSC width=8 seqs=2 chrX:3454850-3454970 ( 21) CCCCCTGC 1 chr2R:23306110-23306230 ( 82) CCCCCTCC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCCTSC MEME-4 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 28250 bayes= 12.9378 E= 3.4e+004 -765 274 -765 -765 -765 274 -765 -765 -765 274 -765 -765 -765 274 -765 -765 -765 274 -765 -765 -765 -765 -765 149 -765 174 177 -765 -765 274 -765 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCCTSC MEME-4 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 3.4e+004 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.500000 0.500000 0.000000 0.000000 1.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCCCCTSC MEME-4 regular expression -------------------------------------------------------------------------------- CCCCCT[CG]C -------------------------------------------------------------------------------- Time 26.11 secs. ******************************************************************************** ******************************************************************************** MOTIF CCTTGGGG MEME-5 width = 8 sites = 2 llr = 27 E-value = 1.7e+004 ******************************************************************************** -------------------------------------------------------------------------------- Motif CCTTGGGG MEME-5 Description -------------------------------------------------------------------------------- Simplified A :::::::: pos.-specific C aa:::::: probability G ::::aaaa matrix T ::aa:::: bits 2.8 ** **** 2.5 ** **** 2.2 ** **** 1.9 ** **** Relative 1.7 ** **** Entropy 1.4 ******** (19.6 bits) 1.1 ******** 0.8 ******** 0.6 ******** 0.3 ******** 0.0 -------- Multilevel CCTTGGGG consensus sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGGGG MEME-5 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- -------- chr2R:20568461-20568581 110 1.27e-06 CTCAGTGCAG CCTTGGGG CAG chr3R:28842070-28842190 40 1.27e-06 TCAAATAAAT CCTTGGGG TTCTTAAATC -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGGGG MEME-5 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2R:20568461-20568581 1.3e-06 109_[+5]_3 chr3R:28842070-28842190 1.3e-06 39_[+5]_73 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGGGG MEME-5 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF CCTTGGGG width=8 seqs=2 chr2R:20568461-20568581 ( 110) CCTTGGGG 1 chr3R:28842070-28842190 ( 40) CCTTGGGG 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGGGG MEME-5 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 4 w= 8 n= 28250 bayes= 12.9378 E= 1.7e+004 -765 274 -765 -765 -765 274 -765 -765 -765 -765 -765 149 -765 -765 -765 149 -765 -765 277 -765 -765 -765 277 -765 -765 -765 277 -765 -765 -765 277 -765 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGGGG MEME-5 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 4 w= 8 nsites= 2 E= 1.7e+004 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif CCTTGGGG MEME-5 regular expression -------------------------------------------------------------------------------- CCTTGGGG -------------------------------------------------------------------------------- Time 32.32 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- chr2L:20328728-20328848 1.14e-02 52_[+1(9.63e-05)]_60 chr3L:14296547-14296667 9.69e-01 120 chr3R:16485976-16486096 9.99e-01 120 chr2R:22316003-22316123 2.46e-01 120 chr3R:26894038-26894158 7.59e-02 120 chr3L:5626612-5626732 8.53e-01 120 chr2L:4622076-4622196 8.41e-02 120 chr3R:18491284-18491404 4.65e-03 23_[+2(3.07e-06)]_89 chr3R:19788912-19789032 5.07e-01 120 chr2L:734266-734386 3.80e-01 120 chr2L:2185501-2185621 2.52e-01 120 chr2L:14259925-14260045 9.96e-01 120 chr3L:14440702-14440822 6.94e-02 88_[+3(7.31e-06)]_24 chrX:8163585-8163705 9.87e-01 120 chr3L:2162757-2162877 6.33e-01 120 chr3L:12025076-12025196 9.99e-01 120 chr2R:7112213-7112333 1.23e-01 2_[+3(6.10e-05)]_110 chr3L:4398044-4398164 1.99e-01 120 chr2L:7627634-7627754 9.33e-01 120 chr2R:22727185-22727305 8.56e-01 120 chr3R:26481383-26481503 2.62e-02 94_[+2(2.54e-05)]_18 chr2L:18746826-18746946 8.90e-02 10_[+3(7.31e-06)]_102 chrX:7637252-7637372 7.20e-01 120 chrX:15156413-15156533 9.25e-01 120 chr3L:6263577-6263697 4.21e-01 120 chr3R:29211841-29211961 9.67e-01 120 chrX:9654097-9654217 9.97e-01 120 chr2L:7513824-7513944 1.47e-01 120 chr3L:15708690-15708810 9.54e-01 120 chrX:15165056-15165176 9.29e-01 120 chr3R:16523563-16523683 2.49e-01 120 chr2L:3645502-3645622 5.10e-01 120 chr3L:9745524-9745644 9.71e-01 120 chr3L:21224375-21224495 9.61e-01 120 chr3R:4957940-4958060 5.44e-01 120 chr2R:18656789-18656909 6.22e-01 120 chr3L:12073216-12073336 9.02e-01 120 chr2R:7114692-7114812 2.90e-01 120 chr2L:4619362-4619482 2.92e-01 120 chrX:15639178-15639298 3.44e-01 120 chr2R:14083116-14083236 7.68e-01 120 chr3R:10531899-10532019 3.92e-03 101_[+2(6.68e-05)]_11 chr3R:18486308-18486428 8.85e-02 120 chrX:715513-715633 5.99e-01 120 chr3L:8319235-8319355 4.32e-01 120 chr3R:23392380-23392500 2.27e-02 120 chr3R:22400383-22400503 6.21e-01 120 chr2L:18348782-18348902 8.91e-01 120 chr3L:21223441-21223561 1.00e+00 120 chr3R:21979529-21979649 2.31e-02 55_[+2(3.07e-06)]_57 chr3L:18096871-18096991 4.78e-01 120 chr2L:4648945-4649065 8.64e-01 120 chrX:13951543-13951663 4.05e-01 120 chr2L:2184823-2184943 1.75e-02 91_[+1(1.28e-06)]_21 chr2R:15233496-15233616 8.68e-01 120 chr3R:28842070-28842190 4.10e-03 39_[+5(1.27e-06)]_73 chr3L:5609633-5609753 8.39e-01 120 chr3L:2582481-2582601 3.99e-01 120 chr3R:31314607-31314727 9.85e-02 120 chr3L:3555201-3555321 7.08e-01 120 chr2L:1538239-1538359 2.42e-01 120 chr3R:22150064-22150184 8.81e-01 120 chr3R:31944355-31944475 8.61e-01 120 chr2R:21801059-21801179 8.58e-01 120 chr2L:3482152-3482272 8.65e-01 120 chr3R:9228063-9228183 5.63e-01 120 chr2R:24925993-24926113 8.55e-01 120 chr3L:18231531-18231651 9.67e-01 120 chr2L:3576634-3576754 7.05e-01 120 chrX:3005911-3006031 9.20e-02 16_[+2(6.68e-05)]_96 chr3R:12315588-12315708 5.04e-03 36_[+1(5.20e-05)]_76 chr2L:653934-654054 8.09e-01 120 chrX:11736575-11736695 3.51e-01 120 chr2L:20370311-20370431 9.86e-01 120 chr2R:12739857-12739977 6.51e-01 120 chr2R:16706833-16706953 4.79e-01 120 chr2R:15600061-15600181 4.16e-01 120 chr3L:14616792-14616912 1.00e+00 120 chr3L:17981248-17981368 9.53e-01 120 chr2R:21783621-21783741 4.81e-03 101_[+3(1.04e-05)]_11 chr3R:18488019-18488139 6.09e-02 77_[+3(7.31e-06)]_35 chr2L:3858233-3858353 2.68e-01 120 chr3L:1484902-1485022 4.81e-01 120 chr3R:30344701-30344821 8.52e-01 120 chr3R:15113699-15113819 1.00e+00 120 chr2R:7161983-7162103 3.25e-01 120 chr2L:3002092-3002212 9.03e-01 120 chrX:5924507-5924627 7.21e-01 120 chr3R:27181227-27181347 9.53e-01 120 chr3R:22395534-22395654 2.55e-01 120 chr2R:13291889-13292009 8.17e-01 120 chr3R:6214374-6214494 7.99e-01 120 chr3R:26478168-26478288 3.14e-01 120 chr3R:12381446-12381566 2.31e-01 120 chr2L:7956471-7956591 3.42e-04 41_[+2(1.04e-05)]_56_[+3(7.31e-06)]_\ 7 chr3R:30872821-30872941 1.00e+00 120 chr2R:10847453-10847573 9.98e-01 120 chrX:15163522-15163642 2.24e-01 120 chr2R:11315542-11315662 9.71e-01 120 chr2L:4065330-4065450 3.29e-01 120 chr3R:30890195-30890315 5.19e-02 107_[+5(5.89e-06)]_5 chr3R:22576368-22576488 1.34e-01 120 chr2R:17845697-17845817 4.88e-01 120 chr2R:21377272-21377392 9.60e-01 120 chr2R:21300886-21301006 8.94e-01 120 chr2R:12720709-12720829 9.37e-01 120 chrX:724608-724728 1.83e-01 120 chr2L:4797716-4797836 9.44e-01 120 chr3L:4745271-4745391 2.58e-01 120 chr2L:15474535-15474655 9.84e-01 120 chr3R:18485366-18485486 2.58e-01 120 chrX:4999154-4999274 4.51e-01 120 chr2L:18752902-18753022 9.85e-02 120 chr2L:4635505-4635625 9.60e-01 120 chr3R:29072972-29073092 3.55e-01 120 chr2L:20335074-20335194 5.87e-01 120 chr3L:4271566-4271686 2.84e-01 120 chr3L:14422261-14422381 7.97e-01 120 chr3L:10376807-10376927 3.05e-01 120 chr3R:15567081-15567201 1.00e+00 120 chr3R:30833239-30833359 5.81e-01 120 chrX:4963101-4963221 5.48e-01 120 chr2L:604253-604373 2.22e-01 120 chr2L:18752165-18752285 9.45e-01 120 chr2R:20568461-20568581 1.40e-05 100_[+3(7.31e-06)]_1_[+5(1.27e-06)]_\ 3 chr3L:741857-741977 2.44e-01 120 chr3L:22106837-22106957 9.25e-01 120 chr2R:8646576-8646696 9.89e-01 120 chr2L:21004954-21005074 4.34e-01 120 chrX:9653397-9653517 9.81e-01 120 chr3L:8782129-8782249 7.51e-01 120 chr2L:18744014-18744134 9.90e-01 120 chr3R:13843739-13843859 9.32e-01 120 chr3L:6308749-6308869 8.73e-01 120 chr2R:23198690-23198810 4.39e-01 120 chr3R:14456559-14456679 9.35e-01 120 chr3R:24204147-24204267 4.55e-01 120 chr2L:20721589-20721709 9.90e-01 120 chrX:1979130-1979250 5.55e-01 120 chrX:4959045-4959165 5.99e-01 120 chr3L:17504698-17504818 9.52e-01 120 chr3L:21918724-21918844 8.27e-01 120 chr3R:14486615-14486735 9.76e-01 120 chrX:5002907-5003027 6.56e-01 120 chr3R:22158491-22158611 6.06e-01 120 chr2L:21246810-21246930 7.66e-01 120 chr3L:18076764-18076884 4.74e-04 4_[+2(1.04e-05)]_35_[+4(4.52e-05)]_\ 38_[+4(8.55e-05)]_19 chr3R:30567378-30567498 7.99e-01 120 chrX:18558698-18558818 4.90e-01 120 chrX:8839516-8839636 9.87e-01 120 chr3R:22594371-22594491 6.55e-01 120 chr2R:16212944-16213064 9.97e-01 120 chrX:8747763-8747883 8.56e-01 120 chr2L:20340783-20340903 5.45e-02 36_[+1(2.55e-06)]_76 chr3R:8875884-8876004 1.18e-02 120 chr3L:19329631-19329751 6.26e-02 120 chr2R:18899103-18899223 9.87e-01 120 chr2R:20055449-20055569 3.74e-03 102_[+5(5.02e-05)]_10 chr2L:21108312-21108432 5.77e-01 120 chr3R:31767717-31767837 9.84e-01 120 chr3L:20983389-20983509 9.26e-01 120 chr3L:20610534-20610654 1.27e-01 31_[+1(9.63e-05)]_81 chr3L:15187901-15188021 8.96e-01 120 chr3R:24024278-24024398 5.97e-01 120 chr3L:7632941-7633061 9.99e-01 120 chr3R:18493932-18494052 4.88e-01 120 chr2L:4886293-4886413 2.63e-01 120 chr3R:13797459-13797579 9.94e-01 120 chr3L:6396040-6396160 4.62e-05 11_[+1(2.19e-07)]_75_[+3(7.81e-05)]_\ 18 chr2R:17811094-17811214 8.83e-01 120 chrX:5013178-5013298 7.22e-01 120 chr2L:18725003-18725123 7.22e-01 120 chr2L:20328101-20328221 1.31e-02 93_[+2(4.33e-06)]_19 chrX:4170633-4170753 7.27e-01 120 chr3R:5324241-5324361 4.80e-01 120 chr3L:11448477-11448597 1.82e-03 83_[+2(3.07e-06)]_29 chr2L:19307812-19307932 4.23e-01 120 chr2L:9669511-9669631 5.93e-01 120 chr3R:16042921-16043041 3.55e-02 120 chr2R:23306110-23306230 1.29e-03 81_[+4(1.15e-06)]_31 chr2R:7173197-7173317 8.78e-03 62_[+3(1.04e-05)]_50 chr3R:22727955-22728075 5.83e-01 120 chr3R:26019362-26019482 7.10e-01 120 chr3R:29847251-29847371 1.01e-02 84_[+3(6.10e-05)]_28 chr2R:8645847-8645967 9.64e-01 120 chr3L:4707961-4708081 3.34e-01 120 chr3L:8765645-8765765 9.20e-01 120 chr2R:13933396-13933516 5.12e-01 120 chr3L:5945713-5945833 8.75e-02 39_[+2(2.54e-05)]_73 chrX:18800341-18800461 6.51e-01 120 chr2L:3731157-3731277 1.32e-01 120 chr3L:9566997-9567117 9.98e-01 120 chrX:3454850-3454970 1.45e-03 20_[+4(5.67e-07)]_92 chr3L:13215045-13215165 2.49e-01 120 chr2R:14081672-14081792 3.05e-01 120 chr2L:18331774-18331894 1.00e+00 120 chr3L:590019-590139 8.29e-02 120 chr3L:10386318-10386438 7.65e-01 120 chr3L:756520-756640 3.98e-02 120 chr2R:19904084-19904204 1.00e+00 120 chr2L:19317947-19318067 6.57e-01 120 chr2R:18663210-18663330 1.88e-01 120 chr3R:23737807-23737927 4.22e-01 120 chr3R:12297346-12297466 2.23e-01 120 chr3R:26496489-26496609 8.96e-01 120 chrX:3739296-3739416 9.10e-01 120 chr2L:7938613-7938733 5.00e-01 120 chr3L:8860048-8860168 7.01e-01 120 chr3L:4346489-4346609 9.53e-01 120 chr3L:21237140-21237260 4.24e-01 120 chrX:2796756-2796876 1.03e-01 120 chr3L:10396685-10396805 7.36e-01 120 chrX:9738628-9738748 5.96e-01 120 chr2R:23761503-23761623 8.18e-01 120 chr3R:30312642-30312762 1.40e-03 29_[+1(1.28e-06)]_83 chr3L:2533176-2533296 9.79e-01 120 chr3R:31768335-31768455 8.36e-02 120 chr3R:31901714-31901834 8.73e-01 120 chr3L:3657014-3657134 2.31e-01 120 chr2R:8358045-8358165 8.02e-01 120 chr2L:3624934-3625054 4.75e-01 120 chr3R:23324059-23324179 7.25e-01 120 chr2L:7043642-7043762 8.74e-01 120 chr3L:787757-787877 7.70e-01 120 chr3R:19075223-19075343 9.58e-01 120 chr3R:23416687-23416807 9.52e-01 120 chr3R:4687343-4687463 8.73e-01 120 chr2L:15466087-15466207 3.24e-01 120 chr3L:6084618-6084738 3.66e-01 120 chr2L:14624016-14624136 3.00e-01 120 chr3L:16643131-16643251 4.74e-01 120 chr2L:18005640-18005760 4.35e-01 120 chr3R:9581109-9581229 8.96e-01 120 chr2R:17635145-17635265 9.50e-01 120 chr2L:8585204-8585324 7.87e-01 120 chr3R:19070716-19070836 7.73e-01 120 chr2L:19574575-19574695 1.07e-01 120 chr3L:18628256-18628376 4.74e-01 120 chrX:13238651-13238771 9.74e-01 120 chrX:1988829-1988949 3.99e-06 74_[+1(5.20e-05)]_13_[+2(3.07e-06)]_\ 7_[+4(2.54e-05)]_2 chr3L:7264258-7264378 9.83e-01 120 chr3R:29982170-29982290 1.09e-01 120 chr2L:843985-844105 2.42e-01 120 chr2L:5567216-5567336 8.02e-01 120 chr3L:14534747-14534867 7.85e-01 120 chr3R:20280691-20280811 1.66e-02 32_[+4(3.23e-06)]_80 chr3R:19255404-19255524 7.75e-01 120 chr3L:11536874-11536994 6.88e-01 120 chr2R:6521281-6521401 9.31e-01 120 chr2R:17076994-17077114 1.00e+00 120 -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because requested number of motifs (5) found. ******************************************************************************** CPU: c27n07.farnam.hpc.yale.internal ********************************************************************************